title: Long-term (30 days) toxicity of NiO nanoparticles for adult zebrafish Danio rerio.
abstract: Nickel oxide in the form of nanoparticles (NiO NPs) is extensively used in different industrial branches. In a test on adult zebrafish, the acute toxicity of NiO NPs was shown to be low, however longlasting contact with this compound can lead to its accumulation in the tissues and to increased toxicity. In this work we determined the 30-day toxicity of NiO NPs using a static test for zebrafish Danio rerio. We found the 30-day LC50 value to be 45.0 mg/L, LC100 (minimum concentration causing 100% mortality) was 100.0 mg/L, and LC0 (maximum concentration causing no mortality) was 6.25 mg/L for adult individuals of zebrafish. Considering a broad use of Ni in the industry, NiO NPs chronic toxicity may have a negative impact on the population of aquatic organisms and on food web dynamics in aquatic systems.
authors.affiliation: Slovak Medical University in Bratislava, Limbová 12, 833 03, Bratislava, Slovakia.
authors.forename: Jevgenij A
authors.initials: JA
authors.lastname: Kovrižnych
authors.affiliation: Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská 9, 841 04 Bratislava, Slovakia.
authors.forename: Ružena
authors.initials: R
authors.lastname: Sotníková
authors.affiliation: Slovak Medical University in Bratislava, Limbová 12, 833 03, Bratislava, Slovakia.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Zeljenková
authors.affiliation: Slovak Medical University in Bratislava, Limbová 12, 833 03, Bratislava, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Rollerová
authors.affiliation: Slovak Medical University in Bratislava, Limbová 12, 833 03, Bratislava, Slovakia.
authors.forename: Elena
authors.initials: E
authors.lastname: Szabová
keywords: nanoparticles; nickel oxide; toxicity; zebrafish