title: Assessment of Tissue Level of Histone Deactylase-2 (HDAC-2) in Patients With Mycosis Fungoides.
abstract: BACKGROUND
  Histone deactylases (HDAC) have a role in the pathogenesis of mycosis fungoides (MF) through their actions on different apoptosis pathways.
  
  
  OBJECTIVE
  To assess the possible role played by HDAC-2 in MF by estimating the tissue expression of HDAC2 mRNA in different stages of MF.
  
  
  METHODS
  This study included 28 MF patients and 30 controls. The HDAC-2 levels were detected by real-time polymerase chain reaction (PCR). Correlations of HDAC-2 levels with clinical presentation and different stages of MF were analyzed.
  
  
  RESULTS
  Mean HDAC-2 level was significantly higher in patients (P < .001) than in controls. HDAC-2 highest mean value was significantly detected in patients with stage IIb, and the lowest mean value was detected in patients with stage Ia (P < .001).
  
  
  CONCLUSIONS
  Up-regulation of tissue HDAC-2 in MF patients might develop a new approach in the understanding of the pathogenesis of MF. Histone deactylases are important targets for molecular cancer therapeutics.
authors.affiliation: Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Amira
authors.initials: A
authors.lastname: El Tawdy
authors.affiliation: Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Iman
authors.initials: I
authors.lastname: Amin
authors.affiliation: Faculty of Medicine, Cairo University, Cairo, Egypt raniamounir@kasralainy.edu.eg.
authors.forename: Rania
authors.initials: R
authors.lastname: Abdel Hay
authors.affiliation: Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Laila
authors.initials: L
authors.lastname: Rashed
authors.affiliation: National Cancer Institute, Cairo University, Cairo, Egypt.
authors.forename: Zeiad
authors.initials: Z
authors.lastname: Gad
mesh_terms: D000328:Adult; D017209:Apoptosis; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D056464:Histone Deacetylase 2 / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D012333:RNA, Messenger; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015854:Up-Regulation
chemical_list: D012333:RNA, Messenger; C533423:HDAC2 protein, human; D056464:Histone Deacetylase 2
keywords: HDAC-2; apoptosis; cancer therapeutics; cell cycle; mycosis fungoides