title: [Effects of DNMT3A gene mutations on prognosis of patients with acute myeloid leukemia: a meta-analysis].
abstract: To evaluate the effects of DNMT3A gene mutation on prognosis of patients with acute myeloid leukemia (AML) by a meta-analysis.
  
  
  
  Methods of Cochrane systematic review was followed by 7 databases,including PubMed, Embase, Ovid, CNKI, CBM, WanFang Data and VIP, were searched for peer-reviewed articles related to DNMT3A gene mutations and prognosis of patients with AML.Then manual retrieval was applied into literature references. After the evaluation of quality and extract of clinical trialliterature data, Stata 11.0 was employed to perform meta-analysis.
  
  
  
  Seven randomized controlled trials involving 1493 cases were included in the meta-analysis. The prognosis of patients with DNMT3A mutations and without DNMT3A mutations was compared. There was no statistically significant difference in complete remission(CR) rate (OR=1.034, 95%CI: 0.596~1.796, P=0.905 between two groups, but the overall survival (OS（HR=1.990, 95%CI: 1.463~2.510, P=0.000 and disease free survival (DFS) (HR= 2.840, 95%CI: 1.063~4.613, P=0.002) of patients without DNMT3A mutations were longer than those with DNMT3A mutation.
  
  
  
  DNMT3A gene mutation is an independent risk factor of poor prognosis of patients with acute myeloid leukemia.
authors.affiliation: Department of Hematology, the First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China;
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Xi
authors.affiliation: Teaching and Research Section of Epidemiology and Health Statistics, Department of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China;
authors.forename: Ling-xia
authors.initials: LX
authors.lastname: Zeng
authors.affiliation: Teaching and Research Section of Epidemiology and Health Statistics, Department of Public Health, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China;
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Yu
authors.affiliation: Department of Hematology, the First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China;
authors.forename: Hua-sheng
authors.initials: HS
authors.lastname: Liu
mesh_terms: D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D009154:Mutation; D011379:Prognosis; D012307:Risk Factors
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A