title: [Influence of smoking on the nasal mucosa mucociliary transport].
abstract: The aim of the study was to compare mucociliary transport between healthy smokers and nonsmokers and to evaluate the influence of the duration of smoking, number of cigarettes per day and age on mucociliary function. The study included 176 subjects divided into two groups. One group consisted of 96 smokers and the other group of 80 nonsmokers. The saccharin test that measures mucociliary transport was performed on all study subjects. Analysis of test results showed a statistically significant difference in mucociliary transport between smokers older than average and the younger ones (t=2.58; df=22; P=0.01 7). Damage to the mucociliary transport was more severe in older smokers. A statistically significant difference in mucociliary transport was also found in smokers with a longer than average duration of smoking habit (t=3.362; df=22; P=0.003). There was no statistically significantly slower mucociliary transport according to the number of cigarettes per day and age at starting smoking. In conclusion, mucociliary transport was statistically slower in smokers that were older and had a longer smoking history as compared with younger smokers having smoking for a shorter time. Smoking has an important effect on mucociliary transport of the nasal mucosa.
authors.forename: Draško
authors.initials: D
authors.lastname: Cikojević
authors.forename: Marina
authors.initials: M
authors.lastname: Krnić
authors.forename: Sandra
authors.initials: S
authors.lastname: Marčina
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology*; D009297:Nasal Mucosa / Q000502:physiology*; D012016:Reference Values; D012439:Saccharin; D012907:Smoking / Q000009:adverse effects* / Q000503:physiopathology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D014028:Tobacco Smoke Pollution; D012439:Saccharin