title: [The study of the expression and the prognostic value of Survivin and Ki67 in pancreatic endocrine tumors].
abstract: OBJECTIVE
  To explore the relationship between the expression of Survivin and Ki67 with prognosis of pancreatic endocrine tumors (PETs).
  
  
  METHODS
  Immunohistochemistry for Survivin and Ki67 was performed in 25 cases of normal pancreatic tissues and 81 cases of PETs by tissue microarrays and to observe the expression and evaluate the relationship with prognosis.
  
  
  RESULTS
  (1)The expression of Survivin and Ki67 in PETs was significantly higher than that in normal pancreatic tissues (P <0.01); (2)The expression of Survivin and Ki67 in PETs was correlated with tissue grading and the TNM-staging (P < 0.05), but not related with tumor size, location and functional status. In addition, the expression of nuclear Survivin was association with lymph node metastasis (P < 0.05). (3)The high expression of Ki67 was related with the expression of nuclear Survivin, but not related with the expression of cytoplasmic Survivin.
  
  
  CONCLUSIONS
  Survivin and Ki67 were both expressed in PETs, which were closely related to the clinical pathological characteristics. They could be used as new indicators in the evaluation of prognosis of PETs. The expression of Survivin in nucleus had more diagnostic significance than that in cytoplasm, and that could be highly correlated with lymph node metastasis, which would be used as a new marker of poor prognosis.
authors.forename: Wang-wang
authors.initials: WW
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Zuo-li
authors.initials: ZL
authors.lastname: Xia
authors.forename: Shi-qiang
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Bao
authors.forename: Zhong-min
authors.initials: ZM
authors.lastname: Lin
authors.forename: Xiu-huan
authors.initials: XH
authors.lastname: Ji
authors.forename: Li-li
authors.initials: LL
authors.lastname: Ying
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Zhao
authors.forename: Meng-fei
authors.initials: MF
authors.lastname: Xu
authors.lastname: Cai Guo-Ping
authors.forename: Guo-rong
authors.initials: GR
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011379:Prognosis; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D000077022:Survivin