title: Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative.
abstract: OBJECTIVE
  We explored whether knee pain or a history of knee injury were associated with a knee injury in the following 12 months.
  
  
  METHODS
  We conducted longitudinal knee-based analyses among knees in the Osteoarthritis Initiative. We included both knees of all participants who had at least 1 followup visit with complete data. Our first sets of exposures were knee pain (chronic knee symptoms and severity) at baseline, 12-month, 24-month, and 36-month visits. Another exposure was a history of injury that we defined as a self-reported injury at any time prior to baseline, 12-month, 24-month, or 36-month visit. The outcome was self-reported knee injury during the past year at 12-month, 24-month, 36-month, and 48-month visits. We evaluated the association between ipsilateral and contralateral knee pain or history of injury and a new knee injury within 12 months of the exposure using generalized linear mixed model for repeated binary outcomes.
  
  
  RESULTS
  A knee with reported chronic knee symptoms or ipsilateral or contralateral history of an injury was more likely to experience a new knee injury in the following 12 months than a knee without chronic knee symptoms (OR 1.84, 95% CI 1.57-2.16) or prior injury (prior ipsilateral knee injury: OR 1.81, 95% CI 1.56-2.09. Prior contralateral knee injury: OR 1.43, 95% CI 1.23-1.66).
  
  
  CONCLUSIONS
  Knee pain and a history of injury are associated with new knee injuries. It may be beneficial for individuals with knee pain or a history of injury to participate in injury prevention programs.
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center. jeffrey.driban@tufts.edu.
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Driban
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center.
authors.forename: Grace H
authors.initials: GH
authors.lastname: Lo
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Eaton
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center.
authors.forename: Lori Lyn
authors.initials: LL
authors.lastname: Price
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center.
authors.forename: Bing
authors.initials: B
authors.lastname: Lu
authors.affiliation: From the Division of Rheumatology, and The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center; Tufts Clinical and Translational Science Institute, Tufts University; Brigham and Women's Hospital; Harvard Medical School, Boston, Massachusetts; Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center; Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas; Center for Primary Care and Prevention, Alpert Medical School of Brown University, Providence, Rhode Island, USA.J.B. Driban, PhD, ATC, CSCS, Assistant Professor, Division of Rheumatology, Tufts Medical Center; G.H. Lo, MD, MSc, Assistant Professor, Medical Care Line and Research Care Line, HSR&D Center of Excellence, Michael E. DeBakey VA Medical Center, and Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine; C.B. Eaton, MD, MS, Director of Primary Care and Prevention, Center for Primary Care and Prevention, Alpert Medical School of Brown University; L.L. Price, MAS, Statistician, Instructor, The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, and Tufts Clinical and Translational Science Institute, Tufts University; B. Lu, MD, DrPH, Assistant Professor, Brigham and Women's Hospital, and Harvard Medical School; T.E. McAlindon, MD, MPH, Chief of Division of Rheumatology, Division of Rheumatology, Tufts Medical Center.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: McAlindon
mesh_terms: D018771:Arthralgia / Q000150:complications / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D020370:Osteoarthritis, Knee / Q000150:complications*; D010147:Pain Measurement; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: KNEE INJURIES; MUSCULOSKELETAL PAIN; OSTEOARTHRITIS