title: Beneficial Effects of Supplementation of the Rare Sugar "D-allulose" Against Hepatic Steatosis and Severe Obesity in Lep(ob)/Lep(ob) Mice.
abstract: A rare sugar, D-allulose (also called D-psicose), has recently been applied as a food supplement in view of controlling diabetes and obesity in Japan. D-allulose has been proven to have unique effects against hyperglycemia and hyperlipidemia in a number of studies using several species of rats and mice. However, the antiobesity effects of D-allulose have not yet been assessed in Lep(ob)/Lep(ob) (ob/ob) mice. Therefore, this study explored the dietary supplemental effects of this sugar in leptin-deficient ob/ob mice. Consequently, the subchronic ingestion of D-allulose in ob/ob mice for 15 wk significantly decreased the body and liver weights, and the loss of body weight was involved in the reduction of the total fat mass, including abdominal visceral fat, and not fat-free body mass, including muscle. Furthermore, D-allulose improved hepatic steatosis, as evaluated using hepatic histological studies and MRI. In the normal mice, none of these parameters were influenced by the single or long-term ingestion of D-allulose. These results indicate that dietary supplementation of D-allulose especially influences postprandial hyperglycemia and obesity-related hepatic steatosis, without exercise therapy or dietary restriction. Therefore, D-allulose may be useful as a supplement for preventing and improving obesity and obesity-related disorders.
authors.affiliation: Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, 769-2193, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Itoh
authors.affiliation: Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, 769-2193, Japan.|Dept. of Pharmacy, Shikoku Medical Center for Children and Adults, Kagawa, 765-8507, Japan.
authors.forename: Shodo
authors.initials: S
authors.lastname: Mizuno
authors.affiliation: Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, 769-2193, Japan.|Otsuka Pharmaceutical Co, Ltd, Second Tokushima Factory, Bulk Pharmaceutical Chemicals Dept, Second Tokushima Factory, Production Headquarters, Tokushima, 771-0192, Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Hama
authors.affiliation: Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, 769-2193, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Oshima
authors.affiliation: Laboratory for Pharmacotherapy and Experimental Neurology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri Univ, Kagawa, 769-2193, Japan.
authors.forename: Miku
authors.initials: M
authors.lastname: Kawamata
authors.affiliation: Dept. of Cell Physiology, Faculty of Medicine, Kagawa Univ, Kagawa, 761-0793, Japan.|Research Laboratory, Matsutani Chemical Industry Co. Ltd, Hyogo, Japan.
authors.forename: Akram
authors.initials: A
authors.lastname: Hossain
authors.affiliation: Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima Univ, Hiroshima, 739-8521, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ishihara
authors.affiliation: Dept. of Cell Physiology, Faculty of Medicine, Kagawa Univ, Kagawa, 761-0793, Japan.|Rare Sugar Research Center, Kagawa Univ, Kagawa, 761-0793, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tokuda
mesh_terms: D041721:3T3-L1 Cells; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001823:Body Composition; D001835:Body Weight; D002454:Cell Differentiation / Q000187:drug effects; D019587:Dietary Supplements; D005234:Fatty Liver / Q000188:drug therapy*; D005632:Fructose / Q000008:administration & dosage*; D020738:Leptin / Q000172:deficiency; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects
chemical_list: D020738:Leptin; C003243:psicose; D005632:Fructose
keywords: D-allulose; dietary supplements; hepatic steatosis; obesity; sugar