title: A novel drug-polyethylene glycol liquid compound method to prepare 10-hydroxycamptothecin loaded human serum albumin nanoparticle.
abstract: Drug loading strategies and the methods derived for implementing those strategies are crucially important to the preparation of drug loaded human serum albumin nanoparticles (HSA-NPs), because each of them is focused on wrapping up specific types of drugs via certain physical and chemical properties. However, poor adaptability still exists to load drugs like model substance 10-hydroxycamptothecin (HCPT) by conventional methods. Because it typically represents a large class of water-insoluble drugs, who also structurally possess a certain number of hydrophilic groups. So even though they majorly have lipophilicity but they are of low liposolubility. This article presents a new concept of a loading strategy that takes a drug polymer liquid compound as a loading medium. The drug polymer liquid compound was made from low weight polyethylene glycol (l-PEG) and HCPT. Consequently, this strategy has managed to fabricate HCPT-loaded HSA-NPs through an unconventional approach that overcomes drawbacks of current loading means and better results have been obtained, like high entrapment efficiency (over 99%) and less toxicity involvement. Afterward, in vitro and in vivo evaluations and characterizations were performed to help with the in-depth interpretation of the loading mechanism in order to reveal and further investigate the possible far-reaching applications of this method.
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gong
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Bingsheng
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
authors.forename: Fanglin
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China. Electronic address: ddsamms606@163.com.
authors.forename: Xingguo
authors.initials: X
authors.lastname: Mei
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012709:Serum Albumin / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D011108:Polymers; D012709:Serum Albumin; D011092:Polyethylene Glycols; C028098:10-hydroxycamptothecin; D002166:Camptothecin
keywords: 10-hydroxycamptothecin; Drug polymer liquid compound; Entrapment efficiency; Human serum albumin; Low weight polyethylene glycol; Nanoparticle drug loading method