title: Hippocampal sharp-wave ripples in waking and sleeping states.
abstract: Waking and sleeping states are privileged periods for distinct mnemonic processes. In waking behavior, rapid retrieval of previous experience aids memory-guided decision making. In sleep, a gradual series of reactivated associations supports consolidation of episodes into memory networks. Synchronized bursts of hippocampal place cells during events called sharp-wave ripples communicate associated neural patterns across distributed circuits in both waking and sleeping states. Differences between sleep and awake sharp-wave ripples, and in particular the accuracy of recapitulated experience, highlight their state-dependent roles in memory processes.
authors.affiliation: Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, United States.
authors.forename: Demetris K
authors.initials: DK
authors.lastname: Roumis
authors.affiliation: Center for Integrative Neuroscience and Department of Physiology, University of California, San Francisco, United States. Electronic address: loren@phy.ucsf.edu.
authors.forename: Loren M
authors.initials: LM
authors.lastname: Frank
mesh_terms: D000818:Animals; D058256:Brain Waves / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*