title: A Case of Fungus Ball-Type Pansinusitis Due to Fusarium proliferatum.
abstract: Incidence of fungal sinusitis due to the genus Fusarium has increased during the last two decades. We report a case of fungus ball sinusitis with multiple sinuses involvement in an Iranian 21-year-old woman. The patient was diagnosed as having a fungus ball-type sinusitis in computed tomography scan. The sinus biopsy revealed fungal structures on histopathological and direct microscopic examinations and a Fusarium species arose in culture. Partial sequencing of the translation elongation factor 1-alpha identified the isolate as F. proliferatum. Removal of all lesions by endoscopic surgery resulted in a favorable outcome. To the best of our knowledge, this is the first case of F. proliferatum-associated fungus ball which involved multi-sinus and highlights the efficiency of molecular methods for discrimination of fungal agents involved.
authors.affiliation: Department of Medical Mycology & Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyed Jamal
authors.initials: SJ
authors.lastname: Hashemi
authors.forename: Mojtaba Mohammadi
authors.initials: MM
authors.lastname: Ardehali
authors.forename: Sassan
authors.initials: S
authors.lastname: Rezaie
authors.forename: Ensieh
authors.initials: E
authors.lastname: Zibafar
authors.forename: Mohseh Gerami
authors.initials: MG
authors.lastname: Shoar
authors.forename: Ali
authors.initials: A
authors.lastname: Rezaei-Matehkolaei
authors.forename: Hassan
authors.initials: H
authors.lastname: Ehteram
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Najafzadeh
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nazeri
mesh_terms: D004724:Endoscopy; D005260:Female; D060585:Fusariosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D005670:Fusarium / Q000302:isolation & purification*; D006651:Histocytochemistry; D006801:Humans; D007492:Iran; D008828:Microbiological Techniques; D008853:Microscopy; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology; D012852:Sinusitis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult