title: Transposon mutagenesis disentangles osteosarcoma genetic drivers.
abstract: The genetic drivers of osteosarcoma have been difficult to identify because of the genomic complexity consistently encountered in cancer cells at diagnosis. A new study uses Sleeping Beauty transposon mutagenesis to drive osteosarcomagenesis in the mouse and identify likely drivers of the disease in humans.
authors.affiliation: Department of Orthopedics and the Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Jones
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000235:genetics*; D004251:DNA Transposable Elements; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D016296:Mutagenesis; D012516:Osteosarcoma / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements