title: [The role of mitochondrial dynamics in cell death].
abstract: Mitochondria are dynamic organelles whose homeostasis is defined by two opposite processes: fission (or fragmentation), or fusion. Fission of mitochondria results in generation of smaller organelles and fusion is when they produce tubular or net-like structures. Although a number of proteins are already known to control the process of fission/fusion additional regulators controlling these processes are being found. The Bcl-2 family members take part in the regulation of apoptosis and according to the current view are involved in the mitochondrial net-like structure maintenance. In this review we will discuss mechanisms of mitochondrial fission/fusion regulation and summarize the available information on the role of Bcl-2 family members in the regulation of mitochondrial fission/fusion dynamics.
authors.forename: D D
authors.initials: DD
authors.lastname: Orlova
authors.forename: V G
authors.initials: VG
authors.lastname: Tribulovich
authors.forename: A V
authors.initials: AV
authors.lastname: Garabadzhiu
authors.forename: N A
authors.initials: NA
authors.lastname: Barlev
authors.forename: S
authors.initials: S
authors.lastname: Martin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D063154:Mitochondrial Dynamics / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D024101:Mitochondrial Proteins; D019253:Proto-Oncogene Proteins c-bcl-2