title: Inhibitors of alanine racemase enzyme: a review.
abstract: Alanine racemase is a fold type III PLP-dependent amino acid racemase enzyme catalysing the conversion of l-alanine to d-alanine utilised by bacterial cell wall for peptidoglycan synthesis. As there are no known homologs in humans, it is considered as an excellent antibacterial drug target. The standard inhibitors of this enzyme include O-carbamyl-d-serine, d-cycloserine, chlorovinyl glycine, alaphosphin, etc. d-Cycloserine is indicated for pulmonary and extra pulmonary tuberculosis but therapeutic use of drug is limited due to its severe toxic effects. Toxic effects due to off-target affinities of cycloserine and other substrate analogs have prompted new research efforts to identify alanine racemase inhibitors that are not substrate analogs. In this review, an updated status of known inhibitors of alanine racemase enzyme has been provided which will serve as a rich source of structural information and will be helpful in generating selective and potent inhibitor of alanine racemase.
authors.affiliation: a Department of Pharmaceutical Chemistry , JSS College of Pharmacy , Udhagamandalam , Tamil Nadu , India.
authors.forename: Mohammed Afzal
authors.initials: MA
authors.lastname: Azam
authors.affiliation: a Department of Pharmaceutical Chemistry , JSS College of Pharmacy , Udhagamandalam , Tamil Nadu , India.
authors.forename: Unni
authors.initials: U
authors.lastname: Jayaram
mesh_terms: D000411:Alanine Racemase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D004791:Enzyme Inhibitors; D000411:Alanine Racemase
keywords: Alanine racemase; antibacterial activity; cycloserine; d-alanine; pyridoxal 5′-phosphate