title: (18)F-sodium fluoride PET/CT for the in vivo visualization of Mönckeberg's sclerosis in a diabetic patient.
abstract: Diabetes is a major frequent cause of atherosclerosis vascular disease. Arterial calcification in diabetic patients is responsible for peripheral vascular involvement. Molecular imaging using (18)F-sodium fluoride ((18)F-NaF) positron emission tomography (PET)/computed tomography (CT) has been recently proposed as a marker to study the in vivo mineralization process in the atheroma plaque. A 69-year-old man with a history of type 2 diabetes and no clinical evidence of peripheral arterial disease underwent an (18)F-NaF PET/CT scan. A linear, well-defined (18)F-NaF uptake was detected along the femoral arteries. In addition, the CT component of the PET/CT identified an unsuspected "tram-track" calcification in his femoral arteries, suggestive of medial calcification (Mönckeberg's sclerosis). In other vascular territories, focal (18)F-NaF uptake was also detected in carotid and aorta atheroma plaques. Molecular imaging with (18)F-NaF PET/CT might provide new functional information about the in vivo vascular calcification process in diabetic patients.
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Quirce
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Martínez-Rodríguez
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain. Electronic address: mnubmj@humv.es.
authors.forename: I
authors.initials: I
authors.lastname: Banzo
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: M
authors.initials: M
authors.lastname: de Arcocha-Torres
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Jiménez-Bonilla
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Martínez-Amador
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Ibáñez-Bravo
authors.affiliation: Servicio de Endocrinología, H.U. Marqués de Valdecilla, Universidad de Cantabria, 39008 Santander, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ramos
authors.affiliation: Servicio de Endocrinología, H.U. Marqués de Valdecilla, Universidad de Cantabria, 39008 Santander, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Amado
authors.affiliation: Servicio de Medicina Nuclear, H.U. Marqués de Valdecilla, Universidad de Cantabria, Grupo Imagen Molecular IDIVAL, 39008 Santander, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Carril
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D050380:Monckeberg Medial Calcific Sclerosis / Q000000981:diagnostic imaging* / Q000209:etiology; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012969:Sodium Fluoride / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride
keywords: (18)F-NaF PET/CT; (18)F-NaF PET/TC; Aterosclerosis; Atherosclerosis; Calcificación vascular; Diabetes; Esclerosis de Mönckeberg; Mönckeberg's sclerosis; Vascular calcification