title: Esophagitis: old histologic concepts and new thoughts.
abstract: BACKGROUND
  Inflammatory lesions of the esophagus are a diverse group, often with nonspecific histologic findings. These benign changes can produce diagnostic difficulties for pathologists.
  
  
  OBJECTIVE
  To discuss the typical histologic findings of a variety of the most common causes of esophagitis (reflux, eosinophilic esophagitis, infections, medications) along with less common issues such as sloughing esophagitis and skin disorders involving the squamous mucosa.
  
  
  METHODS
  The literature has been reviewed to discuss histologic definitions of current and developing issues in the area of esophagitis.
  
  
  CONCLUSIONS
  Histologic features are not entirely sensitive and specific for inflammatory esophageal disorders. Awareness of these problems is essential; clinical and endoscopic information can be very useful in distinguishing among the various lesions.
authors.affiliation: From the Department of Laboratory Medicine (Pathology) and the Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Grin
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Streutker
mesh_terms: D001706:Biopsy / Q000379:methods; D002177:Candidiasis / Q000150:complications; D003424:Crohn Disease / Q000150:complications; D004941:Esophagitis / Q000209:etiology / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D012307:Risk Factors; D012871:Skin Diseases / Q000150:complications
chemical_list: D004364:Pharmaceutical Preparations