title: Q-switched Nd:YAG laser treatment for labial lentigines associated with Peutz-Jeghers syndrome.
abstract: OBJECTIVE
  Labial lentigines associated with Peutz-Jeghers syndrome are cosmetically disfiguring and distressful. Although multiple treatment modalities including Q-switched ruby laser and Q-switched alexandrite laser have been proposed, experience with Q-switched Nd:YAG laser has been lacking. This study aimed to retrospectively evaluate the efficacy and safety of Q-switched Nd:YAG laser (532 nm) for labial lentigines in Peutz-Jeghers syndrome.
  
  
  METHODS
  Demographic and clinical data of 11 patients diagnosed with Peutz-Jeghers syndrome were analyzed. A quartile grading system was used. All patients were treated with a Q-switched Nd:YAG laser system with the following parameters: wavelength 532 nm; spot size 3 mm; pulse duration 5-20 ns; fluence 1.8-2.2 J/cm(2) .
  
  
  RESULTS
  After two to six (mean 3.6) treatment sessions, an average grade of 3.73 was achieved. Eight patients (72.7 %) showed an excellent response with more than 75 % lesion clearance. Three patients (27.3 %) showed a good response. Repeated treatments led to improved clearance of labial lentigines. Age, gender, and Fitzpatrick skin type were not statistically associated with efficacy grades after the first treatment session. Neither recurrence in treated areas nor significant complications were observed.
  
  
  CONCLUSIONS
  Q-switched Nd:YAG laser provides an effective and safe treatment option for labial lentigines associated with Peutz-Jeghers syndrome.
authors.affiliation: Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, China.
authors.forename: Gaorong
authors.initials: G
authors.lastname: Jia
authors.affiliation: Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008047:Lip Diseases / Q000473:pathology* / Q000532:radiotherapy*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D010580:Peutz-Jeghers Syndrome / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome; D055815:Young Adult