title: Evaluation of voice disorders in patients with active laryngeal tuberculosis.
abstract: BACKGROUND
  Laryngeal tuberculosis (LTB) is the most frequent larynx granulomatous disease. In general there is lung involvement, but in an important proportion of cases you can find LTB without pulmonary disease. The lesions observed in LTB, such as ulceration and fibrosis, can interfere in the process of voice production. The involvement of the mucous lining of the vocal folds can change their flexibility and, consequently, change voice quality, and the main symptom is dysphonia present in almost 90% of cases.
  
  
  OBJECTIVE
  To describe the anatomical characteristics and voice quality in LTB patients.
  
  
  METHODS
  A descriptive cross-sectional study was conducted with 24 patients.
  
  
  RESULTS
  The most frequently affected sites were vocal folds in 87.5% patients, vestibular folds in 66.7%, epiglottis in 41.7%, arytenoid in 50%, aryepiglottic folds in 33.3%, and interarytenoid region in 33.3% patients. We found 95.8% cases of dysphonia. The voice acoustic analysis showed 58.3% cases of Jitter alterations, 83.3% of Shimmer and 70.8% of GNE.
  
  
  CONCLUSIONS
  Voice disorders found in active laryngeal tuberculosis are similar to those reported after clinical healing of the disease, suggesting that sequelae and vocal adjustments may install during the active phase of the disease, negatively impacting the process of vocal quality reestablishment.
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil; Departmentof Speech Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Marcia Mendonça
authors.initials: MM
authors.lastname: Lucena
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Fernanda Dos Santos
authors.initials: Fdos S
authors.lastname: da Silva
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Ananda Dutra
authors.initials: AD
authors.lastname: da Costa
authors.affiliation: Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Gabriela Rodrigues
authors.initials: GR
authors.lastname: Guimarães
authors.affiliation: Departmentof Speech Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Ana Cristina Nunes
authors.initials: AC
authors.lastname: Ruas
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Frederico Pereira Bom
authors.initials: FP
authors.lastname: Braga
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Mateus Pereira Bom
authors.initials: MP
authors.lastname: Braga
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: João Gustavo Corrêa
authors.initials: JG
authors.lastname: Reis
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Daniel César Silva
authors.initials: DC
authors.lastname: da Costa
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana Reuter
authors.initials: MR
authors.lastname: Palmeiro
authors.affiliation: Laboratory of Clinical Research in Mycobacteriosis, Evandro Chagas National Instituteof Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
authors.forename: Valéria Cavalcanti
authors.initials: VC
authors.lastname: Rolla
authors.affiliation: Laboratory of Clinical Research and Surveillance in Leishmaniasis, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil; Department of Otorhinolaryngology and Ophthalmology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Cláudia Maria
authors.initials: CM
authors.lastname: Valete-Rosalino
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D055154:Dysphonia; D005260:Female; D006685:Hoarseness; D006801:Humans; D020704:Laryngoscopes; D008297:Male; D008875:Middle Aged; D014387:Tuberculosis, Laryngeal / Q000150:complications*; D014827:Vocal Cords / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology; D014832:Voice Disorders / Q000175:diagnosis* / Q000209:etiology*; D014833:Voice Quality