title: Diagnostic value of autofluorescence imaging combined with narrow band imaging in intraepithelial neoplasia of Barrett's esophagus.
abstract: OBJECTIVE
  To evaluate the diagnostic values of Auto Fluorescence Imaging (AFI) combined with Narrow Band Imaging (NBI) in the diagnosis of the intraepithelial neoplasia of Barrett's esophagus (BE).
  
  
  METHODS
  Seventy four suspicious BE intraepithelial lesions were assessed in 50 patients by AFI, who were further subjected to NBI mode to observe the changes of gastric mucosal capillaries and gastric pits. The corresponding lesions were biopsied for pathological examination.
  
  
  RESULTS
  Among the 74 AFI-diagnosed cases of suspicious lesions, 44 (59.5%) were high-grade intraepithelial neoplasias (BEHGIN), while the remaining 30 cases (40.5%) were false-positive. The NBI-diagnostic results of these 44 BEHGIN lesions were as follows: 39 cases were confirmed and 5 were suspicious; among the 30 false-positive BEHGIN cases, NBI gave 7 false-positive cases. The false-positive rates decreased from 40.5% of AFI to 9.5% (7/74) of NBI-AFI (p<0.05). The positive predictive value of AFI in BEHGIN was 59.5% (44/74), while that of AFI-NBI combination was 84.8% (39/46; p<0.05).
  
  
  CONCLUSIONS
  The AFI-NBI combination technology could significantly improve (p<0.05) the detection rate of BEHGIN.
authors.affiliation: Department of Digestion, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
authors.forename: Nu-Yun
authors.initials: NY
authors.lastname: Jin
authors.forename: Kai
authors.initials: K
authors.lastname: Wang
authors.forename: Shuang-Qin
authors.initials: SQ
authors.lastname: Wei
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Li
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Lei-Ming
authors.initials: LM
authors.lastname: Xu
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000150:complications*; D002278:Carcinoma in Situ / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D005453:Fluorescence; D006801:Humans; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*