title: Dyslipidemia and Psoriasis: A Case Control Study.
abstract: OBJECTIVE
  To compare the mean values of lipid profile in psoriatic patients and healthy controls.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  Department of Dermatology, PNS Shifa, Karachi, from November 2012 to April 2013.
  
  
  METHODS
  Patients with psoriasis fulfilling the inclusion and exclusion criteria were selected from Dermatology Outpatient Department (OPD) of PNS Shifa, Karachi. After fasting for 14 hours, 5 ml of venous blood was drawn in sterile syringe and submitted to the Hospital Laboratory for lipid profile, by enzymatic method on Hitachi (Roshe(®)) using reagents by the same firm. The mean values lipid profile in psoriatic patients versus healthy controls were recorded and compared.
  
  
  RESULTS
  Atotal of 256 patients (128 in each group) were enrolled. Mean lipid profile in both groups revealed cholesterol (mg/dl) value of 203.43 ±1 1.43 in cases and 173.64 ± 13.65 in controls. Triglyceride (mg/dl) was 178.87 ± 43.60 and in cases 144.23 ± 34.01 in controls, HDL-C (mg/dl) was 37.81 ± 10.78 in cases and 41.41 ± 9.72 in controls while LDL-C (mg/dl) was 139.52 ± 13.71 in cases and 109.44 ± 13.80 in controls. Each parameters had p-value < 0.05 which was significant.
  
  
  CONCLUSIONS
  Dyslipidemia was found in a high percentage of psoriatic patients than healthy controls. Psoriatic patients require thorough lipid and cardiovascular examinations as they should be considered as individuals with increased risk of cardiovascular diseases.
authors.affiliation: Department of Dermatology, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
authors.forename: Rabia
authors.initials: R
authors.lastname: Ghafoor
authors.affiliation: Department of Dermatology, PNS Shifa, Karachi.
authors.forename: Ajmal
authors.initials: A
authors.lastname: Rashid
authors.affiliation: Department of Dermatology, PNS Shifa, Karachi.
authors.forename: Muhammad Irfan
authors.initials: MI
authors.lastname: Anwar
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011565:Psoriasis / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides