title: Secretin receptor involvement in prion-infected cells and animals.
abstract: The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice. This gender-specificity is consistent with our finding that prion-infected cells are derived from females. Therefore, our results provide initial insights into the reasons why age of disease onset in certain prion diseases is reported to occur slightly earlier in females than males.
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nishizawa
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Oguma
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nishimura
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sakasegawa
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Teruya
authors.affiliation: Department of Biobank Lifescience, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
authors.forename: Ichiko
authors.initials: I
authors.lastname: Nishijima
authors.affiliation: Department of Neurochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address: doh-ura@med.tohoku.ac.jp.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Doh-ura
mesh_terms: D000818:Animals; D001483:Base Sequence; D045744:Cell Line, Tumor; D017931:DNA Primers; D005260:Female; D020868:Gene Silencing; D008297:Male; D051379:Mice; D016133:Polymerase Chain Reaction; D017096:Prion Diseases / Q000503:physiopathology*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology*; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics / Q000502:physiology*; D012737:Sex Factors
chemical_list: D017931:DNA Primers; D043562:Receptors, G-Protein-Coupled; D011964:Receptors, Gastrointestinal Hormone; C029937:secretin receptor
keywords: Gender effect; Incubation time; Knockout mouse; N2a cells; Prion; Secretin receptor