title: Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment.
abstract: Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have nodular glomerulosclerosis on renal biopsy which on immunofluorescence and electron microscopy confirmed HCDD of immunoglobulin G1 type without any light-chain deposition. We also present an in-depth literature review on HCDD.
authors.affiliation: Department of Histopathology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Swapnil
authors.initials: S
authors.lastname: Rane
authors.affiliation: Department of Histopathology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Seema
authors.initials: S
authors.lastname: Rana
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Chetan
authors.initials: C
authors.lastname: Mudrabettu
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Vivekananda
authors.initials: V
authors.lastname: Jha
authors.affiliation: Department of Histopathology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
keywords: monoclonal immunoglobulin deposition disease; nodular glomerulosclerosis; rapidly progressive renal failure