title: Virilizing adrenocortical carcinoma advancing to central precocious puberty after surgery.
abstract: Adrenocortical carcinoma (ACC) in pediatric and adolescent patients is rare, and it is associated with various clinical symptoms. We introduce the case of an 8-year-old boy with ACC who presented with peripheral precocious puberty at his first visit. He displayed penis enlargement with pubic hair and facial acne. His serum adrenal androgen levels were elevated, and abdominal computed tomography revealed a right suprarenal mass. After complete surgical resection, the histological diagnosis was ACC. Two months after surgical removal of the mass, he subsequently developed central precocious puberty. He was treated with a gonadotropin-releasing hormone agonist to delay further pubertal progression. In patients with functioning ACC and surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion may be a useful option at least every 2 or 3 months after surgery.
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Eu Jeen
authors.initials: EJ
authors.lastname: Yang
authors.affiliation: Department of Obstetrics and Gynecology, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Dong Hyu
authors.initials: DH
authors.lastname: Cho
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Pyung Han
authors.initials: PH
authors.lastname: Hwang
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Dae-Yeol
authors.initials: DY
authors.lastname: Lee
keywords: Adrenocortical Carcinoma; Central Precocious Puberty; Virilism