title: BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small-Cell Lung Cancer.
abstract: OBJECTIVE
  The phase III BEYOND trial was undertaken to confirm in a Chinese patient population the efficacy seen with first-line bevacizumab plus platinum doublet chemotherapy in globally conducted studies.
  
  
  METHODS
  Patients age ≥ 18 years with locally advanced, metastatic, or recurrent advanced nonsquamous non-small-cell lung cancer (NSCLC) were randomly assigned to receive carboplatin (area under the curve, 6) intravenously and paclitaxel (175 mg/m(2)) intravenously (CP) on day 1 of each 3-week cycle, for ≤ six cycles, plus placebo (Pl+CP) or bevacizumab (B+CP) 15 mg/kg intravenously, on day 1 of each cycle, until progression, unacceptable toxicity, or death. The primary end point was progression-free survival (PFS); secondary end points were objective response rate, overall survival, exploratory biomarkers, safety.
  
  
  RESULTS
  A total of 276 patients were randomly assigned, 138 to each arm. PFS was prolonged with B+CP versus Pl+CP (median, 9.2 v 6.5 months, respectively; hazard ratio [HR], 0.40; 95% CI, 0.29 to 0.54; P < .001). Objective response rate was improved with B+CP compared with Pl+CP (54% v 26%, respectively). Overall survival was also prolonged with B+CP compared with Pl+CP (median, 24.3 v 17.7 months, respectively; HR, 0.68; 95% CI, 0.50 to 0.93; P = .0154). Median PFS was 12.4 months with B+CP and 7.9 months with Pl+CP (HR, 0.27; 95% CI, 0.12 to 0.63) in EGFR mutation-positive tumors and 8.3 and 5.6 months, respectively (HR, 0.33; 95% CI, 0.21 to 0.53), in wild-type tumors. Safety was similar to previous studies of B+CP in NSCLC; no new safety signals were observed.
  
  
  CONCLUSIONS
  The addition to bevacizumab to carboplatin/paclitaxel was well tolerated and resulted in a clinically meaningful treatment benefit in Chinese patients with advanced nonsquamous NSCLC.
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China. caicunzhoudr@163.com.
authors.forename: Caicun
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.lastname: Chen
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.initials: X
authors.lastname: Liu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Yunzhong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Lu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.lastname: He
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Baohui
authors.initials: B
authors.lastname: Han
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.initials: G
authors.lastname: Jiang
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Chunhong
authors.initials: C
authors.lastname: Hu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.initials: H
authors.lastname: Zhang
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.initials: G
authors.lastname: Cheng
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
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authors.initials: X
authors.lastname: Song
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: You
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Hongming
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authors.lastname: Pan
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Wenjuan
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authors.lastname: Zheng
authors.affiliation: Caicun Zhou, Shanghai Pulmonary Hospital, Tongji University School of Medicine; Shun Lu and Baohui Han, Shanghai Chest Hospital; Guoliang Jiang, Fudan University Shanghai Cancer Center; Wenjuan Zheng and Anny-Yue Yin, Roche (China) Holding Ltd, Shanghai; Yi-Long Wu, Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences; Jianxing He, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou; Gongyan Chen, Harbin Medical University Cancer Hospital, Harbin; Xiaoqing Liu, Academy of Military Medical Sciences Affiliated Hospital (307 Hospital of People's Liberation Army); Yunzhong Zhu, Beijing Chest Hospital; Jie Wang, Beijing Cancer Hospital; Gang Cheng, Beijing Hospital of Ministry of Health, Beijing; Jifeng Feng, Jiangsu Cancer Hospital, Nanjing; Chunhong Hu, The Second Xiangya Hospital of Central South University, Changsha; Hao Zhang, Cancer Hospital of Shantou University Medical College, Shantou; Xiangqun Song, Affiliated Cancer Hospital of Guangxi Medical University, Nanning; You Lu, West China Hospital, Sichuan University, Chengdu; and Hongming Pan, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Anny-Yue
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mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D014408:Biomarkers, Tumor / Q000032:analysis; D016190:Carboplatin / Q000008:administration & dosage; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002681:China; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage; D010919:Placebos; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D014408:Biomarkers, Tumor; D010919:Placebos; D000068258:Bevacizumab; D016190:Carboplatin; D017239:Paclitaxel