title: Soluble CD14 is a nonspecific marker of monocyte activation.
abstract: Soluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a marker of monocyte activation, not restricted to activation by LPS.
authors.affiliation: aCenter for AIDS Research, Case Western Reserve University School of Medicine, Cleveland, Ohio bDepartment of Microbiology and Immunology, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina cVeterans Administration Medical Center, Cleveland, Ohio, USA.
authors.forename: Carey L
authors.initials: CL
authors.lastname: Shive
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Donald D
authors.initials: DD
authors.lastname: Anthony
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lederman
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018950:Lipopolysaccharide Receptors