title: NIG_MoG: a mouse genome navigator for exploring intersubspecific genetic polymorphisms.
abstract: The National Institute of Genetics Mouse Genome database (NIG_MoG; http://molossinus.lab.nig.ac.jp/msmdb/) primarily comprises the whole-genome sequence data of two inbred mouse strains, MSM/Ms and JF1/Ms. These strains were established at NIG and originated from the Japanese subspecies Mus musculus molossinus. NIG_MoG provides visualized genome polymorphism information, browsing single-nucleotide polymorphisms and short insertions and deletions in the genomes of MSM/Ms and JF1/Ms with respect to C57BL/6J (whose genome is predominantly derived from the West European subspecies M. m. domesticus). This allows users, especially wet-lab biologists, to intuitively recognize intersubspecific genome divergence in these mouse strains using visual data. The database also supports the in silico screening of bacterial artificial chromosome (BAC) clones that contain genomic DNA from MSM/Ms and the standard classical laboratory strain C57BL/6N. NIG_MoG is thus a valuable navigator for exploring mouse genome polymorphisms and BAC clones that are useful for studies of gene function and regulation based on intersubspecific genome divergence.
authors.affiliation: Mammalian Genetics Laboratory, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411-8540, Japan, ttakada@nig.ac.jp.
authors.forename: Toyoyuki
authors.initials: T
authors.lastname: Takada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshiki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Obata
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiroishi
mesh_terms: D000818:Animals; D022202:Chromosomes, Artificial, Bacterial / Q000737:chemistry; D002999:Clone Cells; D030541:Databases, Genetic; D016678:Genome; D005838:Genotype; D054643:INDEL Mutation; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012984:Software; D013045:Species Specificity