title: Fatal H5N6 Avian Influenza Virus Infection in a Domestic Cat and Wild Birds in China.
abstract: H5N6 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the first documented naturally-acquired human H5N6 virus infection in 2014. Here, we report the first cases of fatal H5N6 avian influenza virus (AIV) infection in a domestic cat and wild birds. These cases followed human H5N6 infections in China and preceded an H5N6 outbreak in chickens. The extensive migration routes of wild birds may contribute to the geographic spread of H5N6 AIVs and pose a risk to humans and susceptible domesticated animals, and the H5N6 AIVs may spread from southern China to northern China by wild birds. Additional surveillance is required to better understand the threat of zoonotic transmission of AIVs.
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100021, People's Republic of China [3] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Gao
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China.
authors.forename: Tiecheng
authors.initials: T
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
authors.affiliation: General Station for Surveillance of Wildlife Diseases &Wildlife Borne Disease, State Forestry Administration, Shenyang, 110034, People's Republic of China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: General Station for Surveillance of Wildlife Diseases &Wildlife Borne Disease, State Forestry Administration, Shenyang, 110034, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.affiliation: General Station for Surveillance of Wildlife Diseases &Wildlife Borne Disease, State Forestry Administration, Shenyang, 110034, People's Republic of China.
authors.forename: Dong
authors.initials: D
authors.lastname: Chu
authors.affiliation: General Station for Surveillance of Wildlife Diseases &Wildlife Borne Disease, State Forestry Administration, Shenyang, 110034, People's Republic of China.
authors.forename: Heting
authors.initials: H
authors.lastname: Sun
authors.affiliation: General Station for Surveillance of Wildlife Diseases &Wildlife Borne Disease, State Forestry Administration, Shenyang, 110034, People's Republic of China.
authors.forename: Changjiang
authors.initials: C
authors.lastname: Wu
authors.affiliation: College of Animal Science and Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, People's Republic of China.
authors.forename: Shengnan
authors.initials: S
authors.lastname: Li
authors.affiliation: College of Animal Science and Veterinary Medicine, Jilin Agricultural University, Changchun, 130118, People's Republic of China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
authors.forename: Yuanguo
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Xia
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China.
authors.forename: Weishi
authors.initials: W
authors.lastname: Lin
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.affiliation: State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China.
authors.forename: Hualan
authors.initials: H
authors.lastname: Chen
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100021, People's Republic of China [3] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China [4] Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, People's Republic of China.
authors.forename: Xianzhu
authors.initials: X
authors.lastname: Xia
authors.affiliation: 1] Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, Jilin Province 130122, People's Republic of China [2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, People's Republic of China [3] Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, People's Republic of China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000818:Animals; D000835:Animals, Wild; D001717:Birds; D002415:Cats; D002681:China / Q000453:epidemiology; D024882:Drug Resistance, Viral; D014644:Genetic Variation; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D009980:Influenza A virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D009976:Orthomyxoviridae Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D010802:Phylogeny; D014774:Virulence / Q000235:genetics
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus