title: Management of a pregnant woman with anti-holley alloantibody.
abstract: BACKGROUND
  Holley (Hy) is a high-incidence antigen of the Dombrock blood group system (ISBT 014), present in almost 100% of most populations and more than 99% of Blacks. Since anti-Hy is an extremely rare antibody, data on its clinical relevance and in particular on a possible hemolytic disease of the fetus and newborn (HDFN) are scarce.
  
  
  METHODS
  The pregnant patient underwent two autologous whole blood collections at weeks 17 and 19 of gestation with cryopreservation. In our case autologous whole blood collection was well tolerated. There were no signs of HDFN in the healthy newborn.
  
  
  CONCLUSIONS
  Our case improves our understanding of anti-Hy alloantibodies during pregnancy. Additionally, autologous whole blood collection of RBC units with cryopreservation is a safe and feasible way to manage pregnancies in women with rare alloantibodies, when no compatible donor can be found.
authors.affiliation: Division of Hematology, University Hospital, Basel, Switzerland ; Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Braschler
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Basel, Switzerland.
authors.forename: Cora Alexandra
authors.initials: CA
authors.lastname: Vökt
authors.affiliation: Blood Transfusion Service, Swiss Red Cross, Berne, Switzerland.
authors.forename: Hein
authors.initials: H
authors.lastname: Hustinx
authors.affiliation: Institut National de la Transfusion Sanguine (INTS), Département Centre National de Référence pour les Groupes Sanguins, Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Peyrard
authors.affiliation: Division of Hematology, University Hospital, Basel, Switzerland ; Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Infanti
authors.affiliation: Division of Hematology, University Hospital, Basel, Switzerland ; Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Buser
authors.affiliation: Division of Hematology, University Hospital, Basel, Switzerland ; Blood Transfusion Center, Swiss Red Cross, Basel, Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Holbro
keywords: Anti-Holley alloantibody; HDFN; Hemolytic disease of the fetus and newborn; Pregnancy