title: Synthesis and antifungal activity of ethers, alcohols, and iodohydrin derivatives of sclareol against phytopathogenic fungi in vitro.
abstract: This study synthesized 20 sclareol derivatives. The antifungal activities of these derivatives were evaluated in vitro against five phytopathogenic fungi using the mycelium growth rate method. Among all the tested compounds, compound 16 with one iodine atom and three hydroxyl groups displayed higher fungicidal activities against all the tested phytopathogenic fungi than precursor sclareol. Compound 16 also showed more pronounced antifungal activities against Curvularia lunata (IC50=12.09 μg/mL) and Alternaria brassicae (IC50=14.47 μg/mL) than the positive control, a commercial agricultural fungicide thiabendazole.
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Miaofeng
authors.initials: M
authors.lastname: Ma
authors.affiliation: College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Jili
authors.initials: J
authors.lastname: Feng
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Ruoxin
authors.initials: R
authors.lastname: Li
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Chen
authors.affiliation: College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: orgxuhui@nwsuaf.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
mesh_terms: D000438:Alcohols / Q000737:chemistry / Q000494:pharmacology; D000528:Alternaria / Q000187:drug effects*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D013827:Thiabendazole / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000438:Alcohols; D000935:Antifungal Agents; D004224:Diterpenes; D004987:Ethers; C070760:sclareol; D013827:Thiabendazole
keywords: Antifungal activity; Iodohydrin derivative; Phytopathogenic fungi; Sclareol; Synthesis