title: [The laboratory diagnostic of herpes viral infections under nosocomial pneumonia in oncologic hematologic patients].
abstract: The study was organized to discover diagnostically valuable clinical material for detection of etiologic agent of pneumonia in oncological hematological patients, rate of association of nosocomial pneumonia with herpes viruses and evaluation of viral load in patients with depressed immunity. In oncological hematological patients, half of nosocomial pneumonia cases is associated with herpes virus. In every third patient DNA of Epstein-Barr virus and DNA of type I and II are detected. The most informative material in this case is broncho-alveolar lavage fluid and the most convenient diagnostic technique is polymerase chain reaction in real-time. The low viral load in broncho-alveolar lavage fluid is specfic for Epstein-Barr virus, cytomegalovirus and human herpes virus type VI. The concentration of DNA ofsimple herpes virus type I and type II is located in both high and low values. The paradox phenomena is established concerning more benevolent course of nosocomial pneumonia associated with simple herpes virus type I and II in patients with higher viral load in broncho-alveolar lavage fluid. The further research in this direction is needed.
authors.forename: T A
authors.initials: TA
authors.lastname: Garanja
authors.forename: D S
authors.initials: DS
authors.lastname: Tikhomirov
authors.forename: T A
authors.initials: TA
authors.lastname: Tupoleva
authors.forename: V V
authors.initials: VV
authors.lastname: Troitskaia
authors.forename: E M
authors.initials: EM
authors.lastname: Parovichnikova
authors.forename: G M
authors.initials: GM
authors.lastname: Galstian
authors.forename: F P
authors.initials: FP
authors.lastname: Filatov
mesh_terms: D003428:Cross Infection / Q000097:blood* / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification / Q000472:pathogenicity; D019337:Hematologic Neoplasms / Q000097:blood* / Q000150:complications / Q000821:virology; D006566:Herpesviridae Infections / Q000097:blood* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D011024:Pneumonia, Viral / Q000097:blood* / Q000150:complications / Q000821:virology