title: Biogenesis of endosome-derived transport carriers.
abstract: Sorting of macromolecules within the endosomal system is vital for physiological control of nutrient homeostasis, cell motility, and proteostasis. Trafficking routes that export macromolecules from the endosome via vesicle and tubule transport carriers constitute plasma membrane recycling and retrograde endosome-to-Golgi pathways. Proteins of the sorting nexin family have been discovered to function at nearly every step of endosomal transport carrier biogenesis and it is becoming increasingly clear that they form the core machineries of cargo-specific transport pathways that are closely integrated with cellular physiology. Here, we summarize recent progress in elucidating the pathways that mediate the biogenesis of endosome-derived transport carriers.
authors.affiliation: Department of Cell Biology, Yale School of Medicine, SHM C425B, 333 Cedar Street, New Haven, CT 06520, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Chi
authors.affiliation: Department of Cell Biology, Yale School of Medicine, SHM C425B, 333 Cedar Street, New Haven, CT 06520, USA.
authors.forename: Megan S
authors.initials: MS
authors.lastname: Harrison
authors.affiliation: Department of Cell Biology, Yale School of Medicine, SHM C425B, 333 Cedar Street, New Haven, CT 06520, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Burd
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D011992:Endosomes / Q000378:metabolism* / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology; D006801:Humans; D033921:Vesicular Transport Proteins / Q000378:metabolism*
chemical_list: D033921:Vesicular Transport Proteins