title: Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp. FKI-6713.
abstract: Screening for NADH-fumarate reductase inhibitors led to the isolation of a new ukulactone analog, ukulactone C, as a major polyene compound produced by Talaromyces sp. FKI-6713. The structure of the compound was elucidated as a reduced analog of ukulactone A by 1D- and 2D-NMR experiments. Ukulactone C possessed a potent inhibitory activity (IC(50) = 62 nM) against NADH-fumarate reductase of the roundworm Ascaris suum in vitro.
authors.affiliation: Graduate School of Infection Control Sciences, Kitasato University.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kaifuchi
authors.forename: Mihoko
authors.initials: M
authors.lastname: Mori
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D000818:Animals; D017165:Ascaris suum / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011090:Polyenes / Q000378:metabolism*; D032901:Talaromyces / Q000145:classification / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D007783:Lactones; D011090:Polyenes; C000605309:ukulactone C; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH)