title: [Alterations in cerebral perfusion in patients with systemic sclerosis and cognitive impairment].
abstract: BACKGROUND
  Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis, immunological and vascular abnormalities. Cerebral hypoperfusion can be caused by cerebral ischemia. Cognitive impairment (CI) are a major cause of morbidity in SSc The aim of this study is to estimate the frequency of alterations in cerebral perfusion (CP) in SSc patients with CI.
  
  
  METHODS
  We studied 88 patients with SSc. The Montreal Test (MT) was given to all patients to evaluate CI. To 15 patients with CI and without systemic hypertension, diabetes mellitus, cerebrovascular disease, vasculitis, hypothyroidism, depression, and drugs that interfere with the cognitive assessment, the PC was measured by cerebral gammagram (CG).
  
  
  RESULTS
  Of the 88 patients with ES, 58 had CI by MT. A decrease in CP was observed in following lobes: frontal in 9 of 15 patients, temporal in 7 of 15, and parietal in 3 of 15. Concordance between MT and CG was 60% for the frontal, 46% for the temporal and parietal 13%.
  
  
  CONCLUSIONS
  The CI is common in SSc. A decrease in CP was more frequent in the frontal lobe, predominating in older patients and with longer duration of SSc.
authors.affiliation: Departamento de Medicina Interna, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal. olgavera62@yahoo.com.mx.
authors.forename: Juan
authors.initials: J
authors.lastname: Moreno-Gutiérrez
authors.forename: Luis Alonso
authors.initials: LA
authors.lastname: Coria-Moctezuma
authors.forename: María
authors.initials: M
authors.lastname: del Pilar Cruz-Domínguez
authors.forename: Olga Lidia
authors.initials: OL
authors.lastname: Vera-Lastra
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications* / Q000503:physiopathology / Q000523:psychology
keywords: Cerebral perfusion; Cognitive impairment; Gammagram cerebral; Systemic sclerosis