title: Advanced Imaging in Barrett's Esophagus.
abstract: Barrett's esophagus (BE) is present in up to 5.6% of the US population and is the precursor lesion for esophageal adenocarcinoma. Surveillance endoscopy is the primary management approach for BE. However, standard protocol biopsies have been associated with significant miss rates of dysplastic lesions in patients with BE. Thus, a variety of methods to optimize the imaging of BE have been developed to improve the efficiency and diagnostic yield of surveillance endoscopy in detecting early neoplasia. These techniques use changes that occur at macroscopic, microscopic, and subcellular levels in early neoplasia and are the focus of this article.
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 200 UCLA Medical Plaza, Room 330-37, Los Angeles, CA 90095, USA. Electronic address: raman@mednet.ucla.edu.
authors.forename: V Raman
authors.initials: VR
authors.lastname: Muthusamy
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine at UCLA, 200 UCLA Medical Plaza, Room 330-37, Los Angeles, CA 90095, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Kim
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo School of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Wallace
mesh_terms: D001471:Barrett Esophagus / Q000473:pathology*; D004396:Coloring Agents; D004945:Esophagoscopy; D006801:Humans; D008027:Light; D018613:Microscopy, Confocal; D061848:Optical Imaging / Q000379:methods*
chemical_list: D004396:Coloring Agents
keywords: Autofluorescence imaging; Barrett's esophagus; Chromoendoscopy; Confocal laser endomicroscopy; Imaging; Narrow-band imaging