title: A novel approach to the management of a central giant cell granuloma with denosumab: A case report and review of current treatments.
abstract: OBJECTIVE
  To describe the efficacy of denosumab in the treatment of an aggressive giant cell granuloma of the mandible.
  
  
  METHODS
  Denosumab was administered to a patient with a large aggressive giant cell granuloma of the mandible resistant to standard medical therapy. The effectiveness and response was measured on the basis of patient symptoms and radiological parameters.
  
  
  RESULTS
  A significant reduction in patient symptoms was reported in association with tumour regression on follow up radiographs.
  
  
  CONCLUSIONS
  This report demonstrates potential use of denosumab in aggressive giant cell granulomas of the jaws that have been resistant to medical therapy.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Prince of Wales Hospital, Randwick, NSW, Australia. Electronic address: bengupta@gmail.com.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gupta
authors.affiliation: Department of Oral and Maxillofacial Surgery, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: Norman
authors.initials: N
authors.lastname: Stanton
authors.affiliation: Department of Tissue Pathology and Diagnostic Oncology, Pathology West and the University of Sydney Westmead Hospital, Westmead, NSW, Australia.
authors.forename: Hedley
authors.initials: H
authors.lastname: Coleman
authors.affiliation: Department of Endocrinology, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: Chris
authors.initials: C
authors.lastname: White
authors.affiliation: Department of Oral and Maxillofacial Surgery, Prince of Wales Hospital, Randwick, NSW, Australia.
authors.forename: Jasvir
authors.initials: J
authors.lastname: Singh
mesh_terms: D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000069448:Denosumab / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006101:Granuloma, Giant Cell / Q000188:drug therapy*; D006801:Humans
chemical_list: D050071:Bone Density Conservation Agents; D000069448:Denosumab
keywords: Central giant cell granuloma; Denosumab; Medical therapies