title: Impact of Resistance Training in Subjects With COPD: A Systematic Review and Meta-Analysis.
abstract: BACKGROUND
  The goal of this study was to evaluate the effects of resistance training on subjects with COPD.
  
  
  METHODS
  We performed a systematic search in MEDLINE, PubMed, Embase, CINAHL, Elsevier ScienceDirect, EBM Reviews, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov and also of leading respiratory journals for randomized controlled trials on COPD treatment for ≥ 4 weeks with resistance training compared with non-exercise control or with combined resistance and endurance training compared with endurance training alone. Data from these studies were pooled to calculate odds ratio and weighted mean differences (WMDs) with 95% CI.
  
  
  RESULTS
  Eighteen trials with 750 subjects with advanced COPD met the inclusion criteria. There were 2 primary and 5 secondary outcomes. Compared with non-exercise control, resistance training led to significant improvements in the dyspnea domain of the Chronic Respiratory Disease Questionnaire (WMD of 0.59, 95% CI 0.26-0.93, I2 = 0%, P < .001), skeletal muscle strength, and percent-of-predicted FEV1 (WMD of 6.88%, 95% CI 0.41-13.35%, I2 = 0%, P = .04). The combination of resistance and endurance training significantly improved the St George Respiratory Questionnaire total score (WMD of -7.44, 95% CI -12.62 to -2.25, I2 = 0%, P = .005), each domain score, and skeletal muscle strength. There were no significant differences in 6-min walk distance, 6-min pegboard and ring test, maximum exercise work load, and maximum oxygen consumption between the 2 groups. There were no reports of adverse events related to resistance-training intervention.
  
  
  CONCLUSIONS
  Resistance training can be successfully performed alone or in conjunction with endurance training without increased adverse events during pulmonary rehabilitation in COPD.
authors.affiliation: Department of Respiratory Diseases.
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Liao
authors.affiliation: Medical Examination Center.
authors.forename: Jin-Wu
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Department of Respiratory Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Respiratory Diseases.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Yan
authors.affiliation: Department of Respiratory Diseases, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. gzchenrui@163.com zzyyqqcj7605@163.com.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Diseases gzchenrui@163.com zzyyqqcj7605@163.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
mesh_terms: D000368:Aged; D004417:Dyspnea; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010101:Oxygen Consumption; D010807:Physical Endurance; D029424:Pulmonary Disease, Chronic Obstructive / Q000534:rehabilitation*; D016032:Randomized Controlled Trials as Topic; D055070:Resistance Training / Q000379:methods / Q000706:statistics & numerical data*
keywords: chronic obstructive pulmonary disease; meta-analysis; resistance training