title: Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma.
abstract: Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). The HBV mutations, which include point mutation, deletion, insertion and truncation mutation of HBV gene in 4 open reading frames (S, C, P, X), are closely associated with HCC pathogenesis. Some mutations accumulated during chronic HBV infection could be regarded as a biomarker to predict the occurrence of HCC. The detection of the mutations in clinical practice could be helpful for defining better preventive and therapeutic strategies and, moreover, predicting the progression of liver disease.
authors.affiliation: Xin Zhang, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You'an Hospital affiliated with Capital Medical University, Beijing 100069, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Xin Zhang, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You'an Hospital affiliated with Capital Medical University, Beijing 100069, China.
authors.forename: Hui-Guo
authors.initials: HG
authors.lastname: Ding
keywords: Carcinogenesis; Chronic hepatitis B; Hepatitis B virus; Hepatocellular carcinoma; Mutations