title: [Biofilm formation by group A Streptococci of various types and study of antibiotics effect on this process].
abstract: OBJECTIVE
  Evaluation of the ability to form biofilms by various M, T and MT-types of group A streptococci (GAS), as well as study of the effect of various antibiotics on biofilm formation.
  
  
  METHODS
  43 strains of various M and T type GAS were studied. The cultures were grown in Todd-Hewitt broth with the addition of 0.5% yeast extract. Comparative evaluation of the ability to form biofilm was carried out using photometry. Benzylpenicillin, oxacillin, cepha- losporin, cefuroxime and ceftriaxone antibiotics were used at various concentrations.
  
  
  RESULTS
  GAS differ significantly by their ability to form biofilms. The highest ability was noted in 8 strains--2M, 9M, 12M, 13M, 19M, 30M, 36M-types and 6MT type. Simultaneous introduction of GAS cultures and antibiotics into the culture well, except for ceftriaxone, resulted in growth inhibition of both plankton cells and biofilms.
  
  
  CONCLUSIONS
  The ability of GAS to form biofilm depends on streptococci serotype. During simultaneous introduction of GAS with antibiotics into the well, the biofilm does not form.
authors.forename: T A
authors.initials: TA
authors.lastname: Danilova
authors.forename: G A
authors.initials: GA
authors.lastname: Danilina
authors.forename: A A
authors.initials: AA
authors.lastname: Adzhieva
authors.forename: A G
authors.initials: AG
authors.lastname: Minko
authors.forename: N V
authors.initials: NV
authors.lastname: Alekseeva
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002443:Ceftriaxone / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D003470:Culture Media / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D010933:Plankton / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013045:Species Specificity; D013291:Streptococcus / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D002443:Ceftriaxone; D002444:Cefuroxime; D010400:Penicillin G; D010068:Oxacillin