title: Architectural proteins, transcription, and the three-dimensional organization of the genome.
abstract: Architectural proteins mediate interactions between distant sequences in the genome. Two well-characterized functions of architectural protein interactions include the tethering of enhancers to promoters and bringing together Polycomb-containing sites to facilitate silencing. The nature of which sequences interact genome-wide appears to be determined by the orientation of the architectural protein binding sites as well as the number and identity of architectural proteins present. Ultimately, long range chromatin interactions result in the formation of loops within the chromatin fiber. In this review, we discuss data suggesting that architectural proteins mediate long range chromatin interactions that both facilitate and hinder neighboring interactions, compartmentalizing the genome into regions of highly interacting chromatin domains.
authors.affiliation: Department of Biology, Emory University, 1510 Clifton Rd NE, Atlanta, GA 30322, USA.
authors.forename: Caelin
authors.initials: C
authors.lastname: Cubeñas-Potts
authors.affiliation: Department of Biology, Emory University, 1510 Clifton Rd NE, Atlanta, GA 30322, USA. Electronic address: vcorces@emory.edu.
authors.forename: Victor G
authors.initials: VG
authors.lastname: Corces
mesh_terms: D000818:Animals; D001665:Binding Sites; D002843:Chromatin / Q000502:physiology / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000502:physiology; D044127:Epigenesis, Genetic; D015894:Genome, Human; D006801:Humans; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins
keywords: CCCTC-binding factor; Chromatin; Epigenetics; Insulator; Topologically associating domain