title: Curcumin and cancer: barriers to obtaining a health claim.
abstract: Curcumin is a highly pleiotropic molecule found in the rhizomes of Curcuma longa (turmeric). It is responsible for the yellow color of turmeric and has been shown to inhibit the proliferation of cancer cells and to be of use in preventing or treating a number of diseases. Curcumin has been shown to modulate multiple cell-signaling pathways simultaneously, thereby mitigating or preventing many different types of cancers, including multiple myeloma and colorectal, pancreatic, breast, prostate, lung, head, and neck cancers, in both animal models and humans. Current therapeutic approaches using a single cancer drug for a single target can be expensive, have serious side effects, or both. Consequently, new approaches to the treatment and prevention of cancer, including the integration of curcumin as a viable treatment strategy where dysregulation of many pathways is involved, are warranted. A methodical review of the evidence was performed to evaluate the effects of curcumin in support of a health claim, as established through the regulatory framework of Health Canada, for a relationship between the consumption of curcumin and the prevention and treatment of cancer.
authors.affiliation: J.G. Devassy, I.D. Nwachukwu, and P.J.H. Jones are with the Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. P.J.H. Jones is with the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Jessay G
authors.initials: JG
authors.lastname: Devassy
authors.affiliation: J.G. Devassy, I.D. Nwachukwu, and P.J.H. Jones are with the Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. P.J.H. Jones is with the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Ifeanyi D
authors.initials: ID
authors.lastname: Nwachukwu
authors.affiliation: J.G. Devassy, I.D. Nwachukwu, and P.J.H. Jones are with the Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. P.J.H. Jones is with the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada. peter.jones@umanitoba.ca.
authors.forename: Peter J H
authors.initials: PJ
authors.lastname: Jones
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D003474:Curcumin
keywords: cancer; curcumin; health claim; turmeric