title: Scavenger receptor structure and function in health and disease.
abstract: Scavenger receptors (SRs) are a 'superfamily' of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous proteins and pathogens. New family of SRs and their properties have been identified in recent years, and have now been classified into 10 eukaryote families, defined as Classes A-J. These receptors are classified according to their sequences, although in each class they are further classified based in the variations of the sequence. Their ability to bind a range of ligands is reflected on the biological functions such as clearance of modified lipoproteins and pathogens. SR members regulate pathophysiological states including atherosclerosis, pathogen infections, immune surveillance, and cancer. Here, we review our current understanding of SR structure and function implicated in health and disease.
authors.affiliation: Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Izma Abdul
authors.initials: IA
authors.lastname: Zani
authors.affiliation: Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Sam L
authors.initials: SL
authors.lastname: Stephen
authors.affiliation: Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK.|Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
authors.forename: Nadeem A
authors.initials: NA
authors.lastname: Mughal
authors.affiliation: Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
authors.forename: David
authors.initials: D
authors.lastname: Russell
authors.affiliation: Leeds Vascular Institute, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
authors.forename: Shervanthi
authors.initials: S
authors.lastname: Homer-Vanniasinkam
authors.affiliation: Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Wheatcroft
authors.affiliation: Endothelial Cell Biology Unit, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK. s.ponnambalam@leeds.ac.uk.
authors.forename: Sreenivasan
authors.initials: S
authors.lastname: Ponnambalam
keywords: Atherosclerosis; Oxidized LDL particle; Scavenger receptor; Signal transduction