title: Analytical solution of Luedeking-Piret equation for a batch fermentation obeying Monod growth kinetics.
abstract: Not so many fermentation mathematical models allow analytical solutions of batch process dynamics. The most widely used is the combination of the logistic microbial growth kinetics with Luedeking-Piret bioproduct synthesis relation. However, the logistic equation is principally based on formalistic similarities and only fits a limited range of fermentation types. In this article, we have developed an analytical solution for the combination of Monod growth kinetics with Luedeking-Piret relation, which can be identified by linear regression and used to simulate batch fermentation evolution. Two classical examples are used to show the quality of fit and the simplicity of the method proposed. A solution for the combination of Haldane substrate-limited growth model combined with Luedeking-Piret relation is also provided. These models could prove useful for the analysis of fermentation data in industry as well as academia.
authors.affiliation: Department of Chemical Engineering, Universit, é, Laval, Québec, Canada, G1V 0A6. alain.garnier@gch.ulaval.ca.
authors.forename: Alain
authors.initials: A
authors.lastname: Garnier
authors.affiliation: Department of Chemical Engineering, Universit, é, Laval, Québec, Canada, G1V 0A6.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gaillet
mesh_terms: D061249:Batch Cell Culture Techniques; D019149:Bioreactors / Q000382:microbiology*; D005285:Fermentation; D008962:Models, Theoretical
keywords: Luedeking-Piret relation; Monod kinetics; analytical solution; biochemical engineerin; modeling and simulation studies