title: Certification of a new certified reference material of honokiol.
abstract: Honokiol is the most important active pharmaceutical ingredient in Magnolia officinalis, which is a famous traditional Chinese medicine and commonly used in clinical practice. In order to control the quality of honokiol and related pharmaceuticals, a new certified reference material (CRM) of honokiol was developed. The studies of sample preparation, homogeneity, stability, value assignment, and uncertainty evaluation were accomplished in this paper. Three different methods, including differential scanning calorimetry (DSC), mass balance method (MB), and coulometric titration (CT), were employed to determine the purity of honokiol. Specifically, the DSC and CT methods for purity determination of honokiol were established for the first time. The purity of honokiol CRM, after validation and evaluation, was found to be 99.3%, with an expanded uncertainty of 0.5% (k = 2).
authors.affiliation: Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors.forename: Shiying
authors.initials: S
authors.lastname: Yang
authors.forename: Dezhi
authors.initials: D
authors.lastname: Yang
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.forename: Haohui
authors.initials: H
authors.lastname: Zhou
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Guo
authors.forename: Guanhua
authors.initials: G
authors.lastname: Du
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
mesh_terms: D001713:Biphenyl Compounds / Q000592:standards*; D002568:Certification; D002851:Chromatography, High Pressure Liquid; D017705:Lignans / Q000592:standards*; D012015:Reference Standards; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D001713:Biphenyl Compounds; D017705:Lignans; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols