title: Nasopharyngeal carcinoma with bone marrow metastasis: positive response to weekly paclitaxel chemotherapy.
abstract: A 51-year-old man with nasopharyngeal carcinoma underwent chemoradiotherapy with cisplatin and 5-fluorouracil, followed by a left cervical lymphadenectomy. Distant metastatic disease was excluded using fluoro-deoxyglucose positron emission tomography. Seven months later, bone marrow metastasis and disseminated intravascular coagulation were diagnosed. The patient received weekly paclitaxel therapy and maintained a good performance status for seven months. During the treatment period, the patient developed no severe organ toxicity except for neutropenia. Weekly paclitaxel may therefore be considered as the treatment of choice in patients with advanced or recurrent nasopharyngeal carcinoma with bone marrow metastasis.
authors.affiliation: Clinical Training Center after Graduation, University of Miyazaki Hospital, Japan.
authors.forename: Sae
authors.initials: S
authors.lastname: Miyaushiro
authors.forename: Akira
authors.initials: A
authors.lastname: Kitanaka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kubuki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hidaka
authors.forename: Kotaro
authors.initials: K
authors.lastname: Shide
authors.forename: Takuro
authors.initials: T
authors.lastname: Kameda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sekine
authors.forename: Ayako
authors.initials: A
authors.lastname: Kamiunten
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Umekita
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawabata
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Ishiguro
authors.forename: Kazuya
authors.initials: K
authors.lastname: Shimoda
mesh_terms: D019046:Bone Marrow Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D002277:Carcinoma; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D017239:Paclitaxel / Q000627:therapeutic use*
chemical_list: D017239:Paclitaxel