title: The vascular secret of Klotho.
abstract: Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise uniquely from its presence in the circulation.
authors.affiliation: 1] Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark [2] Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Ewa
authors.initials: E
authors.lastname: Lewin
authors.affiliation: Nephrological Department P, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Klaus
authors.initials: K
authors.lastname: Olgaard
mesh_terms: D000818:Animals; D001011:Aorta / Q000737:chemistry*; D050071:Bone Density Conservation Agents / Q000494:pharmacology*; D004872:Ergocalciferols / Q000494:pharmacology*; D005260:Female; D005966:Glucuronidase / Q000032:analysis*; D006801:Humans; D007668:Kidney / Q000737:chemistry*; D010280:Parathyroid Glands / Q000737:chemistry*; D014511:Uremia / Q000378:metabolism*
chemical_list: D050071:Bone Density Conservation Agents; D004872:Ergocalciferols; D005966:Glucuronidase