title: Myeloid-derived suppressor cells in immunity and autoimmunity.
abstract: Myeloid-derived suppressor cells (MDSCs) play a critical role in suppressing immune responses in patients with cancer or severe inflammation. Recent studies have focused on the strong relationship between MDSCs and autoimmune diseases, such as autoimmune hepatitis, inflammatory bowel disease and experimental autoimmune encephalomyelitis. Interestingly, MDSCs appear to serve multifaceted functions in autoimmunity, playing both protective and pathogenic roles. Therefore, although MDSCs may be a functional target for the therapy of autoimmune diseases, the disorders that accompany such treatments should be noted. In this manuscript, we summarize the functions and molecular regulation of MDSCs in immunity and autoimmune disease.
authors.affiliation: Department of Immunology, School of Basic Medical Science, Fudan University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Yujing
authors.initials: Y
authors.lastname: Bi
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Zhengguo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Guangwei
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D022423:Myeloid Cells / Q000276:immunology*
keywords: MDSCs; T cells; autoimmune disease; immune modulation; innate immunity