title: Crystallization Methods for Preparation of Nanocrystals for Drug Delivery System.
abstract: Low water solubility of drug products causes delivery problems such as low bioavailability. The reduced particle size and increased surface area of nanocrystals lead to the increasing of the dissolution rate. The formulation of drug nanocrystals is a robust approach and has been widely applied to drug delivery system (DDS) due to the significant development of nanoscience and nanotechnology. It can be used to improve drug efficacy, provide targeted delivery and minimize side-effects. Crystallization is the main and efficient unit operation to produce nanocrystals. Both traditional crystallization methods such as reactive crystallization, anti-solvent crystallization and new crystallization methods such as supercritical fluid crystallization, high-gravity controlled precipitation can be used to produce nanocrystals. The current mini-review outlines the main crystallization methods addressed in literature. The advantages and disadvantages of each method were summarized and compared.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Gao
authors.forename: Jingkang
authors.initials: J
authors.lastname: Wang
authors.forename: Yongli
authors.initials: Y
authors.lastname: Wang
authors.forename: Qiuxiang
authors.initials: Q
authors.lastname: Yin
authors.forename: Brian
authors.initials: B
authors.lastname: Glennon
authors.forename: Jian
authors.initials: J
authors.lastname: Zhong
authors.forename: Jinbo
authors.initials: J
authors.lastname: Ouyang
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. hongxunhao@tju.edu.cn.
authors.forename: Hongxun
authors.initials: H
authors.lastname: Hao
mesh_terms: D003460:Crystallization / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*