title: [Prognostic value of hemoglobin concentration in the course of chemoradiotherapy of patients with oropharyngeal squamous cell carcinoma].
abstract: There was performed a comparative analysis of the indicators of immediate and long-term results of chemoradiotherapy in 342 patients with squamous cell oropharyngeal carcinoma depending on hemoglobin level before and after treatment. In patients with normal level of hemoglobin a rate of response to treatment was almost two times higher than that of patients with anemia (75,3% vs. 23,5%) and complete regression of tumors was detected by more than three times often (65,4% vs. 17,6%). The overall five-year survival of patients with anemia was significantly worse than that of patients who had normal hemoglobin level (50,7% vs. 67,7%). Patients who had normal hemoglobin level at the time of discharge demonstrated a five-year overall survival of 75,7%, while those with a hemoglobin level below normal, but more than 80 g/l,--only 57,8%. Hemoglobin concentration was a significant prognostic factor for survival of patients with squamous cell carcinoma of the oral cavity and oropharynx. Low baseline of hemoglobin was also a negative prognostic factor for tumor response to treatment, especially to chemotherapy.
authors.forename: D Yu
authors.initials: DY
authors.lastname: Semin
authors.forename: Yu S
authors.initials: YS
authors.lastname: Mardynsky
authors.forename: S V
authors.initials: SV
authors.lastname: Medvedev
authors.forename: P A
authors.initials: PA
authors.lastname: Isaev
authors.forename: D N
authors.initials: DN
authors.lastname: Derbugov
authors.forename: V V
authors.initials: VV
authors.lastname: Polkin
authors.forename: M U
authors.initials: MU
authors.lastname: Radzhapova
authors.forename: S V
authors.initials: SV
authors.lastname: Vasilkov
mesh_terms: D000328:Adult; D000368:Aged; D000747:Anemia, Hypochromic / Q000097:blood / Q000175:diagnosis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D006454:Hemoglobins