title: Age-Related Features of Cardiomyocyte Ploidy in Patients with Hypertrophic Obstructive Cardiomyopathy.
abstract: Endomyocardial biopsy samples of the interventricular septum from patients with hypertrophic cardiomyopathy isolated during myectomy were examined. We revealed significant variability of cardiomyocyte ploidy (from 2.9c to 13.5c) that directly correlated with myocyte size; the maximum ploidy was found in young patients. Ultrastructural signs of increased contractile and synthetic activity of cells were observed in patients with high DNA content in cardiomyocytes.
authors.affiliation: A. N. Bakulev Research Centre for Cardiovascular Surgery, Russian Academy of Sciences, Moscow, Russia, tatiana@box.ru.
authors.forename: T V
authors.initials: TV
authors.lastname: Sukhacheva
authors.forename: Yu A
authors.initials: YA
authors.lastname: Chudinovskikh
authors.forename: M V
authors.initials: MV
authors.lastname: Eremeeva
authors.forename: R A
authors.initials: RA
authors.lastname: Serov
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging; D001706:Biopsy; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology*; D004247:DNA / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000473:pathology*; D011003:Ploidies; D054088:Ventricular Septum / Q000473:pathology*; D055815:Young Adult
chemical_list: D004247:DNA