title: Dendritic Glycopolymer as Drug Delivery System for Proteasome Inhibitor Bortezomib in a Calcium Phosphate Bone Cement: First Steps Toward a Local Therapy of Osteolytic Bone Lesions.
abstract: Establishment of drug delivery system (DDS) in bone substitute materials for local treatment of bone defects still requires ambitious solutions for a retarded drug release. We present two novel DDS, a weakly cationic dendritic glycopolymer and a cationic polyelectrolyte complex, composed of dendritic glycopolymer and cellulose sulfate, for the proteasome inhibitor bortezomib. Both DDS are able to induce short-term retarded release of bortezomib from calcium phosphate bone cement in comparison to a burst-release of the drug from bone cement alone. Different release parameters have been evaluated to get a first insight into the release mechanism from bone cements. In addition, biocompatibility of the calcium phosphate cement, modified with the new DDS was investigated using human mesenchymal stromal cells.
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.|Organic Chemistry of Polymers, Technische Universität Dresden, 01062 Dresden, Germany.
authors.forename: Christin
authors.initials: C
authors.lastname: Striegler
authors.affiliation: Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schumacher
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Effenberg
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Müller
authors.affiliation: Department of Internal Medicine V, Section Multiple Myeloma, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Seckinger
authors.affiliation: Laboratory for Experimental Trauma Surgery, Justus-Liebig-University Gießen, Schubertstr. 81, 35392 Giessen, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schnettler
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.|Organic Chemistry of Polymers, Technische Universität Dresden, 01062 Dresden, Germany.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Voit
authors.affiliation: Department of Internal Medicine V, Section Multiple Myeloma, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. dirk.hose@med.uni-heidelberg.de.
authors.forename: Dirk
authors.initials: D
authors.lastname: Hose
authors.affiliation: Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. michael.gelinsky@tu-dresden.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Gelinsky
authors.affiliation: Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany. applhans@ipfdd.de.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Appelhans
mesh_terms: D001843:Bone Cements; D000069286:Bortezomib / Q000008:administration & dosage* / Q000494:pharmacology; D002130:Calcium Phosphates; D002482:Cellulose / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D050091:Dendrimers / Q000737:chemistry*; D006801:Humans; D008320:Maltose / Q000031:analogs & derivatives*; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects*; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000737:chemistry; D061988:Proteasome Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D050091:Dendrimers; D061988:Proteasome Inhibitors; D008320:Maltose; D000069286:Bortezomib; D011094:Polyethyleneimine; D002482:Cellulose; C020254:cellulose sulfate; C020243:calcium phosphate
keywords: calcium phosphate bone cement; dendritic glycopolymer; drug release; polyelectrolyte complex