title: Clinical asthma phenotyping: A trial for bridging gaps in asthma management.
abstract: Asthma is a common disease affecting millions of people worldwide and exerting an enormous strain on health resources in many countries. Evidence is increasing that asthma is unlikely to be a single disease but rather a series of complex, overlapping individual diseases or phenotypes, each defined by its unique interaction between genetic and environmental factors. Asthma phenotypes were initially focused on combinations of clinical characteristics, but they are now evolving to link pathophysiological mechanism to subtypes of asthma. Better characterization of those phenotypes is expected to be most useful for allocating asthma therapies. This article reviews different published researches in terms of unbiased approaches to phenotype asthma and emphasizes how the phenotyping exercise is an important step towards proper asthma treatment. It is structured into three sections; the heterogeneity of asthma, the impact of asthma heterogeneity on asthma management and different trials for phenotyping asthma.
authors.affiliation: Magdy Mohamed Zedan, Wafaa Nabil Laimon, Amal Mohamed Osman, Mohamed Magdy Zedan, Department of Asthma, Allergy and Immunology, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Magdy Mohamed
authors.initials: MM
authors.lastname: Zedan
authors.affiliation: Magdy Mohamed Zedan, Wafaa Nabil Laimon, Amal Mohamed Osman, Mohamed Magdy Zedan, Department of Asthma, Allergy and Immunology, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Wafaa Nabil
authors.initials: WN
authors.lastname: Laimon
authors.affiliation: Magdy Mohamed Zedan, Wafaa Nabil Laimon, Amal Mohamed Osman, Mohamed Magdy Zedan, Department of Asthma, Allergy and Immunology, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Amal Mohamed
authors.initials: AM
authors.lastname: Osman
authors.affiliation: Magdy Mohamed Zedan, Wafaa Nabil Laimon, Amal Mohamed Osman, Mohamed Magdy Zedan, Department of Asthma, Allergy and Immunology, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
authors.forename: Mohamed Magdy
authors.initials: MM
authors.lastname: Zedan
keywords: Asthma heterogenity; Asthma phenotypes; Asthma subtypes; Asthma syndrome; Endotypes