title: Lack of Association between the TSPAN18 Gene and Schizophrenia Based on New Data from Han Chinese and a Meta-Analysis.
abstract: Tetraspanin-18 (TSPAN18) potentially plays a role in the calcium signaling that is associated with dopamine-induced cortical neuron apoptosis and is considered to be an important mechanism in the pathogenesis of schizophrenia (SCZ). Furthermore, a genome-wide association study (GWAS) identified TSPAN18 as a possible susceptibility gene for SCZ. To validate these findings and reveal the effects of different inheritance models, seven single nucleotide polymorphisms (SNPs) of the TSPAN18 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent via the SNPscan method. Single SNP, genotype, and association analyses with different models (i.e., additive, dominant, and recessive models) were performed, and the published datasets (2062 cases and 2053 controls) were combined with our results to determine the inheritance effects of the SNPs on SCZ. We observed genotypes and allele distributions of TSPAN18 gene did not show any significant associations in the Han Chinese population based on our experimental and meta-analytical results. Our findings indicate that the TSPAN18 gene is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.
authors.affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zhangbao_814@mail.xjtu.edu.cn.
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Stomatology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China. sheraer@gmail.com.
authors.forename: Da-Xu
authors.initials: DX
authors.lastname: Li
authors.affiliation: Department of Food and Biological Engineering, Henan Industry & Trade Vocational College, Zhengzhou 451191, China. forensics@mail.xjtu.edu.cn.
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. fanqianrui@stu.xjtu.edu.cn.
authors.forename: Qian-Rui
authors.initials: QR
authors.lastname: Fan
authors.affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. liwenhao@stu.xjtu.edu.cn.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Li
authors.affiliation: College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. zufeifeng@mail.xjtu.edu.cn.
authors.forename: Zu-Fei
authors.initials: ZF
authors.lastname: Feng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D059470:Tetraspanins / Q000235:genetics*
chemical_list: C556852:TSPAN18 protein, human; D059470:Tetraspanins
keywords: TSPAN18 gene; association; meta; schizophrenia; single nucleotide polymorphisms