title: [Angiogenic factors can be used when pre-eclampsia is suspected].
abstract: Pre-eclampsia complicates 7% of pregnancies. The heterogeneity of the syndrome makes it difficult to assess its development and complications, and the current models have low predictive values. Studies indicate a significant difference in the levels of the angiogenic factors: placental growth factor (PlGF) and soluble fms-like tyrosin kinase 1 (sFlt-1), as well as the sFlt-1/PlGF ratio in women with pre-eclampsia compared to women without pre-eclampsia. These angiogenic factors can also be used to help find the women at risk for complications. However, before implementing PlGF and sFlt-1/PlGF ratio in the diagnosis and risk assessment, establishment and further validation of cut-offs are needed.
authors.affiliation: Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, Blegdamsvej 3B, 2200 København N. jcn135@alumni.ku.dk.
authors.forename: Mille Kyhn
authors.initials: MK
authors.lastname: Andrea
authors.forename: Jacob Alexander
authors.initials: JA
authors.lastname: Lykke
mesh_terms: D015415:Biomarkers / Q000097:blood; D003718:Denmark; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1