title: Analgesic effect of nasal salmon calcitonin during the early post-fracture period of the distal radius fracture.
abstract: To investigate the analgesic effect of nasal salmon calcitonin on the post-fracture period of distal radius fracture.
  
  
  
  In this prospective randomized double-blind study, forty-one postmenopausal women with a recent distal radius fracture treated conservatively were randomly assigned to receive either 200 IU of intranasal salmon calcitonin or placebo daily for 3 months following fracture. The assessment of the patient's pain was recorded using the Visual Analogue Scale (VAS).
  
  
  
  The average age of the calcitonin group was 67.11 (SD, ±8.68) years and 64.91 (SD, ±7.48) of the placebo group. In the calcitonin group, the mean VAS score improved from 4.05 to 0.53 while in the placebo group from 3.36 to 0.32. A higher decrease of VAS score during the first post-fracture period was observed in the calcitonin group.
  
  
  
  In the study, there is a statistically significant calcitonin mediated analgesic effect in the immediate post fracture period (at 10 days) when compared to placebo group. These results are in accordance with literature referring to the analgesic effect of calcitonin in the acute osteoporotic vertebral compression fracture. Thus calcitonin administration could be recommended to a short term course in acute osteoporotic conservatively treated distal radius fractures.
authors.affiliation: Laboratory for Research of Musculoskeletal System "Theodoros Garofalidis", University of Athens, KAT Hospital; 10 Athinas str., Kifissia, 145 61, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Karponis
authors.affiliation: Hellenic Osteoporosis Foundation, 5 Agias Varvaras str., Kifissia 145 61, Athens, Greece.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Rizou
authors.affiliation: 2nd Department of Orthopaedic Surgery, "KAT" Accident's Hospital, 2 Nikis str., Kifissia, 145 61, Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Pallis
authors.affiliation: 2nd Department of Orthopaedic Surgery, "KAT" Accident's Hospital, 2 Nikis str., Kifissia, 145 61, Athens, Greece.
authors.forename: C P
authors.initials: CP
authors.lastname: Zafeiris
authors.affiliation: 2nd Department of Orthopaedic Surgery, "KAT" Accident's Hospital, 2 Nikis str., Kifissia, 145 61, Athens, Greece.
authors.forename: D F
authors.initials: DF
authors.lastname: Georgiou
authors.affiliation: Laboratory for Research of Musculoskeletal System "Theodoros Garofalidis", University of Athens, KAT Hospital; 10 Athinas str., Kifissia, 145 61, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Galanos
authors.affiliation: Department of Hand Surgery-Upper Limb-Microsurgery, "KAT" Accident's Hospital, 2 Nikis str., Kifissia, 145 61, Athens, Greece.
authors.forename: F
authors.initials: F
authors.lastname: Giannoulis
authors.affiliation: Laboratory for Research of Musculoskeletal System "Theodoros Garofalidis", University of Athens, KAT Hospital; 10 Athinas str., Kifissia, 145 61, Athens, Greece.|Hellenic Osteoporosis Foundation, 5 Agias Varvaras str., Kifissia 145 61, Athens, Greece.
authors.forename: G P
authors.initials: GP
authors.lastname: Lyritis
mesh_terms: D000281:Administration, Intranasal; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage* / Q000627:therapeutic use*; D002116:Calcitonin / Q000008:administration & dosage* / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000188:drug therapy; D058866:Osteoporotic Fractures / Q000150:complications / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011446:Prospective Studies; D011885:Radius Fractures / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; C028815:salmon calcitonin; D002116:Calcitonin