title: Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.
abstract: Phagocytosis of malaria pigment (hemozoin) induces increased activity of matrix metalloproteinase (MMP)-9, an endopeptidase involved in cytokine regulation. In this study, we examined whether a common functional MMP-9 promoter polymorphism (rs3918242) affects Plasmodium falciparum infection in pregnancy. Eighteen percent of Ghanaian primiparae carried the minor T allele. It was associated with reduced odds of placental hemozoin and of placental as well as peripheral blood parasitemia. The results indicate that a common MMP-9 polymorphism protects against placental malaria indicating that this endopeptidase is involved in susceptibility to P. falciparum.
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Thittayil Suresh
authors.initials: TS
authors.lastname: Apoorv
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana prakashbabuphanithi@gmail.com.
authors.forename: Phanithi Prakash
authors.initials: PP
authors.lastname: Babu
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Meese
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Prabhanjan P
authors.initials: PP
authors.lastname: Gai
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: George
authors.initials: G
authors.lastname: Bedu-Addo
authors.affiliation: Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India; Institute of Tropical Medicine and International Health, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Medicine, Komfo Anoyke Teaching Hospital, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: Frank P
authors.initials: FP
authors.lastname: Mockenhaupt
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005869:Ghana; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D010920:Placenta / Q000469:parasitology*; D010922:Placenta Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000235:genetics*; D065840:Protective Factors; D055815:Young Adult
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9