title: Negative Cooperativity in the Binding of Imidazolium and Viologen Ions to a Pillar[5]arene-Crown Ether Fused Host.
abstract: A pillar[5]arene-crown ether fused bicyclic host 1 was found to be able to recognize an imidazolium ion G1 by its pillar[5]arene subunit and a viologen ion G2 by its crown ether receptor discriminatively. The simultaneous binding of G1 and G2 by 1 resulted in the formation of a three-component host-guest complex G1⊂1⊃G2. Negative heterotropic cooperative effects were displayed by G1 and G2 in their binding to 1 and were investigated by stepwise bindings of G1 and G2 to 1.
authors.affiliation: †Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.|‡University of Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Hu
authors.affiliation: †Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Hu
authors.affiliation: §Medicinal Chemistry, ChemBridge Research Laboratories Inc., San Diego, California 92127, United States.
authors.forename: Yahu A
authors.initials: YA
authors.lastname: Liu
authors.affiliation: †Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
authors.forename: Jiu-Sheng
authors.initials: JS
authors.lastname: Li
authors.affiliation: †Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Jiang
authors.affiliation: †Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China.|¶School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wen
mesh_terms: D047250:Calixarenes; D043844:Crown Ethers / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D014755:Viologens / Q000737:chemistry*
chemical_list: D043844:Crown Ethers; D007093:Imidazoles; D007477:Ions; D000644:Quaternary Ammonium Compounds; D014755:Viologens; C570642:pillar(5)arene; D047250:Calixarenes