title: Predictors of outcome in decompensated liver disease: validation of the SOFA-L score.
abstract: A growing number of patients with liver disease are being referred for critical care support. We have recently shown that a combination of lactate and SOFA score (SOFA-L score) may provide an accurate, objective measurement of prognosis in a group of patients admitted to ICU with alcoholic liver disease. This score has not been validated in an independent patient cohort. A retrospective study was performed where patients admitted to our ICU with decompensated liver disease (any cause) were included. The SOFA-L score accurately predicted in-hospital mortality in this group of patients with an area under the ROC curve of 0.83. Sensitivity and specificity were 65% and 87% respectively SOFA-L performed superior to SOFA, MELD and MELD-Na scores. This study validates the use of the SOFA-L score in the initial 24 hours of ICU admission as an accurate predictor of mortality in this group of patients with a high mortality.
authors.forename: R
authors.initials: R
authors.lastname: ffrench-O'Carroll
authors.forename: S
authors.initials: S
authors.lastname: Frohlich
authors.forename: N
authors.initials: N
authors.lastname: Murphy
authors.forename: N
authors.initials: N
authors.lastname: Conlon
mesh_terms: D003422:Critical Care; D017052:Hospital Mortality; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D017093:Liver Failure / Q000175:diagnosis / Q000401:mortality*; D063305:Organ Dysfunction Scores; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index
chemical_list: D019344:Lactic Acid