title: Lipid-protein interplay and lateral organization in biomembranes.
abstract: The distribution of lipids and membrane proteins within and between cellular membranes is carefully regulated. This sorting of lipids and proteins results in compositional differences between membrane compartments, bilayer leaflets, and lateral domains in the bilayer plane. The lateral organization of lipids and proteins has proven challenging to investigate, and the driving mechanisms remains unclear. Lipid self-organization has an essential role in the formation of lateral membrane structure, but the role of transmembrane proteins is not well known. This review focuses on how lateral lipid structure can affect the lateral distribution of proteins and how proteins could influence the organization of lipids in biomembranes.
authors.affiliation: Biochemistry, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, FIN-20520 Turku, Finland. Electronic address: tnyholm@abo.fi.
authors.forename: Thomas K M
authors.initials: TK
authors.lastname: Nyholm
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002784:Cholesterol / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D021962:Membrane Microdomains / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins; D010713:Phosphatidylcholines; D002784:Cholesterol
keywords: Cholesterol; Liquid ordered phase; Membrane raft; Protein-lipid interactions