title: Cerebral Hypoperfusion and Hypometabolism Detected by Arterial Spin Labeling MRI and FDG-PET in Early-Onset Alzheimer's Disease.
abstract: OBJECTIVE
  Early-onset Alzheimer's disease (EOAD) is frequently associated with atypical clinical presentations and its early detection remains a challenging issue. In this study, we used arterial spin labeling (ASL), a noninvasive perfusion MRI sequence, and [(18)F]-FDG-PET to detect the perfusion and metabolic features in patients with EOAD.
  
  
  METHODS
  All patients were investigated in the French reference center for young-onset dementia and were assessed by MRI, including a pseudo-continuous ASL (pCASL) sequence, and [(18)F]-FDG-PET. Quantitative analyses and intermodality comparison with correlation analysis were made after data processing including correction of partial volume effects, cortical projection, and specific intensity normalization.
  
  
  RESULTS
  We prospectively included 37 patients with EOAD with a mean age of 58.3 years. The areas of most severe hypoperfusion detected with ASL were located in the parietal lobes, the precuneus, the right posterior cingulate cortex, and the frontal lobes (P < .05). The areas of lowest glucose metabolism detected by [(18)F]-FDG-PET were identified in the temporoparietal cortex and the precuneus (P < .05). Hypometabolic regions were more extensive than hypoperfused regions on ASL maps whereas ASL highlighted alterations in the frontal lobes without apparent hypometabolism on [(18)F]-FDG-PET maps.
  
  
  CONCLUSIONS
  ASL and [(18)F]-FDG-PET detected pathological areas of similar distribution mainly located in the inferior parietal lobules and local zones in the temporal cortex in patients with EOAD. Our preliminary study showed that ASL and [(18)F]-FDG-PET may have a complementary role in combination with structural MRI for the assessment of suspected EOAD.
authors.affiliation: Groupement des Hôpitaux de l'Institut Catholique de Lille/Faculté de Médecine et de Maïeutique, Lille, France.|Department of Radiology, Hospital Saint-Philibert, Lomme, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Verclytte
authors.affiliation: U1171. In-vivo Imaging Platform, Predictive Medicine and Therapeutic Research Institute, Université Lille Nord de France, Lille, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Lopes
authors.affiliation: Neuroimaging Department, CHU Lille, Lille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lenfant
authors.affiliation: Memory Resources and Research Center, CHU Lille, Lille, France.
authors.forename: Adeline
authors.initials: A
authors.lastname: Rollin
authors.affiliation: Neuroimaging Department, CHU Lille, Lille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Semah
authors.affiliation: Department of Neuroradiology, CHU Lille, Lille, France.|U1171. In-vivo Imaging Platform, Predictive Medicine and Therapeutic Research Institute, Université Lille Nord de France, Lille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leclerc
authors.affiliation: Memory Resources and Research Center, CHU Lille, Lille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: Department of Neuroradiology, CHU Lille, Lille, France.|U1171. In-vivo Imaging Platform, Predictive Medicine and Therapeutic Research Institute, Université Lille Nord de France, Lille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Delmaire
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D019788:Fluorodeoxyglucose F18
keywords: Alzheimer's disease; Arterial spin labeling; dementia; early-onset Alzheimer's disease; positron emission tomography