title: [Syphilis and pregnancy].
abstract: Syphilis is a sexually transmitted disease responsible for a congenital severe infection. Congenital syphilis is complicated by fetal loss/neonatal death (50%), prematurity (25%) and major long term sequelae in other surviving children (20%). Every woman delivering a stillborn after 20WG should be tested for syphilis. Early screening is the cornerstone of prevention, and should be repeated in women at higher risk of contamination. Maternal management relies on early benzathine penicillin administration. Neonatal management relies on early diagnosis and prompt adequate penicillin therapy.
authors.affiliation: Assistance publique-Hôpitaux de Paris, université Paris Descartes Sorbonne Paris Cité, hôpital Necker-Enfants-Malades, service de maladies infectieuses et tropicales, 75015 Paris, France; Institut Pasteur, centre national de référence Listeria, centre collaborateur OMS Listeria, unité de biologie des infections, Inserm U1117, 75013 Paris, France. Electronic address: caroline.charlier@nck.aphp.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Charlier
authors.affiliation: Assistance publique-Hôpitaux de Paris, université Paris Descartes Sorbonne Paris Cité, hôpital Cochin Port Royal, centre national de référence syphilis, 75014 Paris, France.
authors.forename: Nadjet
authors.initials: N
authors.lastname: Benhaddou
authors.affiliation: Assistance publique-Hôpitaux de Paris, université Paris Descartes Sorbonne Paris Cité, hôpital Cochin Port Royal, centre national de référence syphilis, 75014 Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013587:Syphilis / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission