title: Synthesis andin vitroactivity of platinum(II) complexes of two fluorenylspirohydantoins against a human tumour cell line.
abstract: This paper presents a method for synthesis and cytotoxicity of new platinum(II) complexes of (9'-fluorene)-spiro-5-hydantoin (L1) and (9'-fluorene)-spiro-5-(2-thiohydantoin) (L2). The new obtained complexes were studied by elemental analysis: ultraviolet-visible, attenuated total reflection Fourier transform infrared (ATR-FTIR), and1H- and13C-NMR for Pt(II) compounds and additionally Raman spectroscopy for free ligands. Based on the experimental data, the most probable structure of the complexes is suggested. In the present study, we have examined cytotoxic activity of (9'-fluorene)-spiro-5-hydantoin (L1) and (9'-fluorene)-spiro-5-(2-thiohydantoin) (L2) and their Pt(II) complexes on the retinoblastoma cell line WERI-Rb-1.
authors.affiliation: Faculty of Chemistry, University of Plovdiv , Plovdiv , Bulgaria.
authors.forename: Petja
authors.initials: P
authors.lastname: Marinova
authors.affiliation: Faculty of Plant protection and Agroecology, Agricultural University , Plovdiv , Bulgaria.
authors.forename: Marin
authors.initials: M
authors.lastname: Marinov
authors.affiliation: Depatment of Biology, Medical University , Plovdiv , Bulgaria.
authors.forename: Maria
authors.initials: M
authors.lastname: Kazakova
authors.affiliation: Depatment of Biology, Medical University , Plovdiv , Bulgaria.
authors.forename: Yana
authors.initials: Y
authors.lastname: Feodorova
authors.affiliation: Faculty of Chemistry, University of Plovdiv , Plovdiv , Bulgaria.
authors.forename: Plamen
authors.initials: P
authors.lastname: Penchev
authors.affiliation: Depatment of Biology, Medical University , Plovdiv , Bulgaria.
authors.forename: Victoria
authors.initials: V
authors.lastname: Sarafian
authors.affiliation: University of Ruse , Razgrad , Bulgaria.
authors.forename: Neyko
authors.initials: N
authors.lastname: Stoyanov
keywords: (9′-fluorene)-spiro-5-(2-thiohydantoin); (9′-fluorene)-spiro-5-hydantoin; cytotoxic/antiproliferative effects; fluorenylspirohydantoins; metal complexes