title: Bis-arylidene oxindole-betulinic Acid conjugate: a fluorescent cancer cell detector with potent anticancer activity.
abstract: Molecules offering simultaneous detection and killing of cancer cells are advantageous. Hybrid of cancer cell-selective, ROS generator betulinic acid and bis-arylidene oxindole with amino propyl-linker is developed. With intrinsic fluorescence, the molecule exhibited cancer cell-specific residence. Further, it generated ROS, triggered apoptosis, and exhibited potent cytotoxicity in cancer cells selectively. We demonstrate the first example and use of isatins as betulinic acid conjugate for selective detection of cancer and subsequent killing of cancer cells via apoptosis.
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India ; Department of Organic Chemistry, Indian Association for Cultivation of Science , Jadavpur, Kolkata 700 032, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Pal
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Ganguly
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Chowdhuri
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Md
authors.initials: M
authors.lastname: Yousuf
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Avijit
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kotcherlakota
authors.affiliation: Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India.
authors.forename: Susanta
authors.initials: S
authors.lastname: Adhikari
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology , Hyderabad 500 007, India.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Banerjee
keywords: Fluorescent oxindole; ROS; apoptosis; betulinic acid; cancer cell detection