title: Effects of interleukin-6 on the bio-electric activity of rat atrial tissue under normal conditions and during gradual stretching.
abstract: Using the micro-electrode technique we studied the effects of interleukin-6 on bio-electric activity of rat atrial tissue under normal conditions and after gradual stretching. It was shown that IL-6 caused increasing of the duration of the action potential at the levels of 25, 50, and 90% re-polarization. The hump-like depolarization at APD90 appeared 7-10 min after initial stretching and transformed into single extra-potentials after tension removing. Perfusion with IL-6 for more than 20 min led to the appearance of atrial fibrillation even with the application of slight tension. Close observation of the IL-6 induced mechanisms and stretch induced APD alteration, confirmed the existence of a tight link between examined cytokine and stretch induced mechanisms.
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
authors.forename: V M
authors.initials: VM
authors.lastname: Mitrokhin
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Ss. Cyril and Methodius" University, P.O. Box 162, 1000 Skopje, Macedonia. Electronic address: m.mitko@gmail.com.
authors.forename: M I
authors.initials: MI
authors.lastname: Mladenov
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: A G
authors.initials: AG
authors.lastname: Kamkin
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology; D016275:Atrial Function / Q000187:drug effects*; D004553:Electric Conductivity; D005682:Gadolinium / Q000494:pharmacology; D006325:Heart Atria / Q000187:drug effects*; D015850:Interleukin-6 / Q000494:pharmacology*; D008297:Male; D008839:Microelectrodes; D009200:Myocardial Contraction / Q000502:physiology; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015850:Interleukin-6; D005682:Gadolinium
keywords: Action potential; Atrium; Heart; Interleukin-6; Stretch