title: The Relationship Between Water Structure and Blood Compatibility in Poly(2-methoxyethyl Acrylate) (PMEA) Analogues.
abstract: Six types of poly(2-methoxyethyl acrylate) (PMEA) analogues were synthesized and the water structure in the hydrated polymers was characterized using differential scanning calorimetry (DSC). The hydrated PMEA analogues exhibited the different amounts of intermediate water. Non-thrombogenicity evaluation was performed on PMEA analogues for platelet adhesion and protein adsorption. Platelet adhesion was suppressed on PMEA analogues. In addition, the protein adsorption and deformation were suppressed by increasing the amount of intermediate water. This study demonstrates that the amount of intermediate water might play a key role in expressing the blood compatibility of polymeric materials.
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.|Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kobayashi
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Kusakari
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Watahiki
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Oikawa
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.|International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hoshiba
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. tanaka@yz.yamagata-u.ac.jp.|Institute for Materials Chemistry and Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. tanaka@yz.yamagata-u.ac.jp.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000179:Acrylates / Q000737:chemistry* / Q000494:pharmacology*; D000327:Adsorption; D001672:Biocompatible Materials; D001769:Blood; D002152:Calorimetry, Differential Scanning; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology*; D011506:Proteins / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins; C413485:poly(2-methoxyethylacrylate); D014867:Water
keywords: biomaterial; blood compatibility; intermediate water; protein adsorption; water structure