title: Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT.
abstract: OBJECTIVE
  To date, PROPELLER MRI, a breathing-motion-insensitive technique, has not been assessed for cystic fibrosis (CF) lung disease. We compared this technique to CT for assessing CF lung disease in children and adults.
  
  
  METHODS
  Thirty-eight stable CF patients (median 21 years, range 6-51 years, 22 female) underwent MRI and CT on the same day. Study protocol included respiratory-triggered PROPELLER MRI and volumetric CT end-inspiratory and -expiratory acquisitions. Two observers scored the images using the CF-MRI and CF-CT systems. Scores were compared with intra-class correlation coefficient (ICC) and Bland-Altman plots. The sensitivity and specificity of MRI versus CT were calculated.
  
  
  RESULTS
  MRI sensitivity for detecting severe CF bronchiectasis was 0.33 (CI 0.09-0.57), while specificity was 100% (CI 0.88-1). ICCs for bronchiectasis and trapped air were as follows: MRI-bronchiectasis (0.79); CT-bronchiectasis (0.85); MRI-trapped air (0.51); CT-trapped air (0.87). Bland-Altman plots showed an MRI tendency to overestimate the severity of bronchiectasis in mild CF disease and underestimate bronchiectasis in severe disease.
  
  
  CONCLUSIONS
  Motion correction in PROPELLER MRI does not improve assessment of CF lung disease compared to CT. However, the good inter- and intra-observer agreement and the high specificity suggest that MRI might play a role in the short-term follow-up of CF lung disease (i.e. pulmonary exacerbations).
  
  
  CONCLUSIONS
  PROPELLER MRI does not match CT sensitivity to assess CF lung disease. PROPELLER MRI has lower sensitivity than CT to detect severe bronchiectasis. PROPELLER MRI has good to very good intra- and inter-observer variability. PROPELLER MRI can be used for short-term follow-up studies in CF.
authors.affiliation: Radiology Department, General Hospital Ca' Foncello, Treviso, Italy.|Pediatric Pulmonology Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.|Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Ciet
authors.affiliation: Radiology, University of Rome "Sapienza", Rome, Italy.
authors.forename: Goffredo
authors.initials: G
authors.lastname: Serra
authors.affiliation: Radiology Department, General Hospital Ca' Foncello, Treviso, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bertolo
authors.affiliation: Radiology, Erasmus MC, Rotterdam, The Netherlands.|Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Sandra
authors.initials: S
authors.lastname: Spronk
authors.affiliation: Pediatrics, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: Mirco
authors.initials: M
authors.lastname: Ros
authors.affiliation: Institute of Nuclear Medicine, University College London (UCL), London, UK.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fraioli
authors.affiliation: Pediatrics, University of Rome Sapienza, Rome, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Quattrucci
authors.affiliation: Verona CF Center, Azienda Ospedaliera di Verona, Verona, Italy.
authors.forename: M Baroukh
authors.initials: MB
authors.lastname: Assael
authors.affiliation: Radiology, University of Rome "Sapienza", Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Catalano
authors.affiliation: Department of Medicine-DIMED, University of Padova, Padova, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Pomerri
authors.affiliation: Pediatric Pulmonology Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands.|Radiology, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Harm A W M
authors.initials: HA
authors.lastname: Tiddens
authors.affiliation: Radiology Department, General Hospital Ca' Foncello, Treviso, Italy. gmorana@ulss.tv.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Morana
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009038:Motion; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Comparative study; Computed tomography (CT); Cystic fibrosis (CF); Lung; Magnetic resonance imaging (MRI)