title: Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor.
abstract: 4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
authors.forename: Christine
authors.initials: C
authors.lastname: Basmadjian
authors.forename: Helene
authors.initials: H
authors.lastname: Malka-Mahieu
authors.affiliation: Laboratory of Therapeutic Innovation (UMR 7200), University of Strasbourg-CNRS, Faculty of Pharmacy, 67401 Illkirch, France. desaubry@unsitra.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Desaubry
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects*