title: [Challenges of personalized medicine for cystic fibrosis].
abstract: Personalized medicine, or P4 medicine for "Personalized", "Predictive", "Preventive" and "Participatory", is currently booming for cystic fibrosis, with the development of therapies targeting specific CFTR mutations. The various challenges of personalized medicine applied to cystic fibrosis issues are discussed in this paper.
authors.affiliation: Service de pneumologie pédiatrique, centre de ressources et de compétences pour la mucoviscidose, centre de référence des maladies respiratoires rares, hôpital Trousseau, AP-HP, 26, avenue du Dr. Netter, 75012 Paris, France; Unité Inserm U938, centre de recherche Saint-Antoine, 34, rue Crozatier, 75012 Paris, France; Université Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France. Electronic address: harriet.corvol@trs.aphp.fr.
authors.forename: H
authors.initials: H
authors.lastname: Corvol
authors.affiliation: Service de pneumologie pédiatrique, centre de ressources et de compétences pour la mucoviscidose, centre de référence des maladies respiratoires rares, hôpital Trousseau, AP-HP, 26, avenue du Dr. Netter, 75012 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Taytard
authors.affiliation: Unité Inserm U938, centre de recherche Saint-Antoine, 34, rue Crozatier, 75012 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Tabary
authors.affiliation: Unité Inserm U938, centre de recherche Saint-Antoine, 34, rue Crozatier, 75012 Paris, France; Université Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Le Rouzic
authors.affiliation: Unité Inserm U938, centre de recherche Saint-Antoine, 34, rue Crozatier, 75012 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Guillot
authors.affiliation: Service de pneumologie pédiatrique, centre de ressources et de compétences pour la mucoviscidose, centre de référence des maladies respiratoires rares, hôpital Trousseau, AP-HP, 26, avenue du Dr. Netter, 75012 Paris, France; Unité Inserm U938, centre de recherche Saint-Antoine, 34, rue Crozatier, 75012 Paris, France; Université Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Clement
mesh_terms: D002648:Child; D003550:Cystic Fibrosis / Q000235:genetics / Q000628:therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D006801:Humans; D009154:Mutation; D057285:Precision Medicine
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator