title: [Association of NEDD4 gene polymorphisms with schizophrenia and its clinical characteristics in Chinese Han population].
abstract: OBJECTIVE
  To assess the association of neural precursor cell expressed developmentally down-regulated 4 (NEDD4) with schizophrenia.
  
  
  METHODS
  Five single nucleotide polymorphisms (SNPs) of the NEDD4 gene were genotyped by TaqMan SNP genotyping assay in an independent sample of 464 individuals with schizophrenia and 487 healthy controls from eastern Han Chinese population. Clinical data were collected with a general information questionnaire and Positive and Negative Syndrome Scale (PANSS).
  
  
  RESULTS
  Frequencies of rs3088077 (allelic: χ2=18.024, P=0.000; genotypic: χ2=16.634, P=0.000), rs7162435 (allelic: χ2=6.771, P=0.009; genotypic: χ2=7.352, P=0.025) and rs2303579 (allelic: χ2=11.253, P=0.001; genotypic: χ2=12.248, P=0.002) were found to be significant different between the two groups. Moreover, TT of rs7162435 was significantly correlated with scores of factors of excitement and hostility (14.53±3.925, F=3.551, P=0.029).
  
  
  CONCLUSIONS
  rs3088077, rs7162435 and rs2303579 of the NEDD4 gene may be associated with schizophrenia. Moreover, the TT genotype of rs7162435 may increase the severity of excitement and hostility. Our results may provide a clue for delineating the connection between the glutamate hypothesis of schizophrenia and ubiquitination.
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong 250012, P.R.China. liulf521@163.com.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Bi
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Cui
authors.forename: Chao
authors.initials: C
authors.lastname: Han
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Sun
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.forename: Limin
authors.initials: L
authors.lastname: Yang
authors.forename: Dongdong
authors.initials: D
authors.lastname: Qiao
authors.forename: Wenwen
authors.initials: W
authors.lastname: Han
authors.forename: Lanfen
authors.initials: L
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D002681:China / Q000208:ethnology; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D000075702:Nedd4 Ubiquitin Protein Ligases; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D055815:Young Adult
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618483:Nedd4 protein, human; D044767:Ubiquitin-Protein Ligases