title: Fibronectin chorused cohesion between endothelial progenitor cells and mesenchymal stem cells of mouse bone marrow.
abstract: Endothelial progenitor cells (EPCs) could function as niche cells to promote self&mdash;renewal of mesenchymal stem cells (MSCs) in the mouse bone marrow. Cohesion was the basis of the two cells to display their biological functions to each other. In this study, we investigated the mechanism of cohesion between MSCs and EPCs. And demonstrated that fibronectin (FN) in EPCs activated the integrin &#945;5&#946;1 of MSCs and further mediated cell-cell cohesion. Integrin &#945;5&#946;1 and its FN ligand played critical roles not only in single&mdash;cell line adhesion, but also in adhesion between stem and niche cells. This novel finding is important to understand the cross&mdash;talk between MSCs and their niche cells.
authors.affiliation: Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China.
authors.forename: H W
authors.initials: HW
authors.lastname: Zhang
authors.affiliation: School of Medicine, Shihezi University Department of Immunology Xinjiang China.
authors.forename: X L
authors.initials: XL
authors.lastname: Chen
authors.affiliation: School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Lin
authors.affiliation: School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China.
authors.forename: J
authors.initials: J
authors.lastname: Xia
authors.affiliation: Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China.
authors.forename: J X
authors.initials: JX
authors.lastname: Hou
authors.affiliation: First Affiliated Hospital, School of Medicine, Shihezi University Medical Laboratory Xinjiang China.
authors.forename: D
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Huazhong University of Science and Technology Tongji Hospital, Tongji Medical School Hubei China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xi
authors.affiliation: School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.affiliation: School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China.
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Medicine, Shihezi University, Shihezi The First Affiliated Hospital Xinjiang China.
authors.forename: W
authors.initials: W
authors.lastname: Feng
authors.affiliation: First Affiliated Hospital, School of Medicine, Shihezi University Department of General Surgery Xinjiang China pengxinyu2000&commat;sina.com.
authors.forename: X Y
authors.initials: XY
authors.lastname: Peng
authors.affiliation: First Affiliated Hospital, School of Medicine, Shihezi University Department of General Surgery Xinjiang China wxwshz&commat;126.com.
authors.forename: X W
authors.initials: XW
authors.lastname: Wu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism*; D002448:Cell Adhesion; D002454:Cell Differentiation; D002478:Cells, Cultured; D003470:Culture Media; D066026:Endothelial Progenitor Cells / Q000378:metabolism*; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism*; D039081:Integrin alpha5beta1 / Q000378:metabolism*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D034622:RNA Interference; D012333:RNA, Messenger / Q000096:biosynthesis; D034741:RNA, Small Interfering
chemical_list: D003470:Culture Media; D005353:Fibronectins; D039081:Integrin alpha5beta1; D012333:RNA, Messenger; D034741:RNA, Small Interfering