title: A Forty Year Odyssey in Metallo-Organic Chemistry.
abstract: In this invited Perspective, I provide a personal account highlighting several of my group's research contributions in metallo-organic chemistry over the past 40 years. Our early work focused primarily in stoichiometric structure/reactivity of transition metal-organic compounds and their use in organic synthesis. More recent efforts have centered on the discovery and development of new metal-catalyzed organic reactions via reactive metal-organic intermediates. The major research findings that are described here include (1) propargyl-cobalt complexes as electrophilic agents for C-C and C-Nu coupling; (2) the activation of carbon dioxide by metal complexes; (3) metal-promoted C-H nitrogenation reactions; (4) oxo-metal catalyzed deoxygenation reactions; and (5) catalyst discovery via dynamic templating with substrate- and transition-state analogues.
authors.affiliation: Department of Chemistry and Biochemistry Stephenson Life Sciences Center, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.
authors.forename: Kenneth M
authors.initials: KM
authors.lastname: Nicholas
mesh_terms: D002384:Catalysis; D002625:Chemistry, Organic; D003035:Cobalt / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D003035:Cobalt; D010165:Palladium