title: Regioselective direct oxidative C-H cyanation of quinoline and its derivatives catalyzed by vanadium-containing heteropoly acids.
abstract: A direct oxidative C-H cyanation of quinoline and its derivatives using trimethylsilyl cyanide as the cyano source and molecular oxygen as the terminal oxidant has been developed. In the presence of catalytic amounts of vanadium-containing heteropoly acids, e.g., H7PV4Mo8O40, cyanation of various quinoline and its derivatives preferentially took place at the 4-position, affording the corresponding substituted 4-cyanoquinolines as the major products.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. tmizuno@mail.ecc.u-tokyo.ac.jp.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Ning
authors.initials: N
authors.lastname: Xu
authors.forename: Xiongjie
authors.initials: X
authors.lastname: Jin
authors.forename: Kosuke
authors.initials: K
authors.lastname: Suzuki
authors.forename: Noritaka
authors.initials: N
authors.lastname: Mizuno