title: Chirality-based Au@Ag Nanorod Dimers Sensor for Ultrasensitive PSA Detection.
abstract: A novel biosensor for ultrasensitive detection of prostate-specific antigen (PSA) was established based on gold nanorod (Au NR) dimers assembly. The circular dichroism signal was significantly amplified by a silver shell depositing on the surface of the Au NR dimers. A low limit of detection of 0.076 aM and high specificity were observed within the range of 0.1 to 50 aM target PSA. The developed biosensor has the potential to serve as a general platform for the detection of cancer biomarkers.
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Tang
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Si
authors.initials: S
authors.lastname: Li
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Liguang
authors.initials: L
authors.lastname: Xu
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Kuang
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Libing
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, People's Republic of China.
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Xu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D043942:Nanotubes / Q000737:chemistry*; D017430:Prostate-Specific Antigen / Q000097:blood* / Q000737:chemistry; D015203:Reproducibility of Results; D012834:Silver / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D014408:Biomarkers, Tumor; D012834:Silver; D006046:Gold; D017430:Prostate-Specific Antigen
keywords: Au@Ag nanorod dimers; PSA detection; chirality