title: Synthesis, spectral, structural characterization and biological investigation of m-Xylylenediaminium-bis (p-toluenesulfonate) monohydrate.
abstract: Novel organic charge transfer complex, m-xylylenediaminium-bis (p-toluenesulfonate) monohydrate (XDPTS) have been synthesized and crystallized to the triclinic system with space group P-1 and the lattice parameters obtained are a=9.9265(7) Å, b=9.9676(6) Å, c=13.4948(10) Å, α=71.95(6)°, β=77.02(6)°, γ=76.851(5)°. The synthesized complex structure was confirmed by IR, (1)H NMR and (13)C NMR spectral analysis. Pharmacology activities of charge transfer complex were evaluated through antimicrobial, DNA binding/cleavage, antioxidant and cytotoxicity studies. The results reveal that the compound shows good antimicrobial activity against various antibacterial and antifungal species. The DNA interaction indicated that the compound could interact with DNA through intercalation, which is further confirmed by viscosity measurements. The compound should have weak to moderate capacity of scavenging with DPPH, Hydroxyl and ABTS radicals. The cytotoxicity has been evaluated by MTT assay method against MCF-7 cancer cell line.
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors.forename: Venkatesan
authors.initials: V
authors.lastname: Murugesan
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors.forename: Munusamy
authors.initials: M
authors.lastname: Saravanabhavan
authors.affiliation: Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India. Electronic address: msekar966@gmail.com.
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Sekar
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000633:toxicity; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D014783:Viscosity / Q000187:drug effects; D014992:Xylenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001557:Benzenesulfonates; D003959:Diamines; D007364:Intercalating Agents; D014992:Xylenes; C003774:xylenediamine; D004247:DNA; C029501:4-toluenesulfonic acid
keywords: Antimicrobial; Antioxidant; Crystal structure; Cytotoxicity; DNA binding/cleavage