title: Therapeutics targeting the inflammasome after central nervous system injury.
abstract: Innate immunity is part of the early response of the body to deal with tissue damage and infections. Because of the early nature of the innate immune inflammatory response, this inflammatory reaction represents an attractive option as a therapeutic target. The inflammasome is a component of the innate immune response involved in the activation of caspase 1 and the processing of pro-interleukin 1β. In this article, we discuss the therapeutic potential of the inflammasome after central nervous system (CNS) injury and stroke, as well as the basic knowledge we have gained so far regarding inflammasome activation in the CNS. In addition, we discuss some of the therapies available or under investigation for the treatment of brain injury, spinal cord injury, and stroke.
authors.affiliation: Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla. Electronic address: JdeRivero@med.miami.edu.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: de Rivero Vaccari
authors.affiliation: Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla.
authors.forename: W Dalton
authors.initials: WD
authors.lastname: Dietrich
authors.affiliation: Department of Neurological Surgery, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Fla; Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, Fla.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Keane
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology / Q000627:therapeutic use*; D007249:Inflammation / Q000276:immunology*; D020196:Trauma, Nervous System / Q000188:drug therapy* / Q000276:immunology
chemical_list: D058847:Inflammasomes