title: The Management of Schizophrenia in Clinical Practice (MOSAIC) Registry: a focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization.
abstract: BACKGROUND
  The Management of Schizophrenia in Clinical Practice (MOSAIC), a disease-based registry of schizophrenia, was initiated in December 2012 to address important gaps in our understanding of the impact and burden of schizophrenia and to provide insight into the current status of schizophrenia care in the US. Recruitment began in December 2012 with ongoing assessment continuing through May 2014.
  
  
  METHODS
  Participants were recruited from a network of 15 centralized Patient Assessment Centers supporting proximal care sites. Broad entry criteria included patients diagnosed with schizophrenia, schizophreniform or schizoaffective disorder, presenting within the normal course of care, in usual treatment settings, aged ≥18years and able to read and speak English.
  
  
  RESULTS
  By May 2014, 550 participants (65.8% male, 59.8% White, 64.4% single, mean age 42.9years), were enrolled. The majority had a diagnosis of schizophrenia (62.0%). Mean illness duration at entry was 15.0years. Common comorbidities at entry were high lipid levels (26.9%), hypertension (23.1%) and type II diabetes (13%). Participants were categorized by baseline overall Clinical Global Impression-Schizophrenia Severity Score as minimally (9.1%), mildly (25.3%), moderately (39.9%), markedly (22.3%) and severely (3.4%) ill. Most commonly used second generation antipsychotics at entry were risperidone (17.8%), clozapine (16.5%), olanzapine (14.0%), aripiprazole (13.6%) and quetiapine (5.6%).
  
  
  CONCLUSIONS
  No large-scale patient registry has been conducted in the US to longitudinally follow patients with schizophrenia and describe symptom attributes, support network, care access and disease burden. These data provide important epidemiological, clinical and outcome insights into the burden of schizophrenia in the US.
authors.affiliation: Saint Louis University, 1438 South Grand Boulevard, Saint Louis, MO 63104, USA. Electronic address: hnasral@SLU.edu.
authors.forename: Henry A
authors.initials: HA
authors.lastname: Nasrallah
authors.affiliation: University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA.
authors.forename: Philip D
authors.initials: PD
authors.lastname: Harvey
authors.affiliation: Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Casey
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Csilla T
authors.initials: CT
authors.lastname: Csoboth
authors.affiliation: Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
authors.forename: James I
authors.initials: JI
authors.lastname: Hudson
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Julian
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Lentz
authors.affiliation: University of California, Los Angeles, CA 90095, USA.
authors.forename: Keith H
authors.initials: KH
authors.lastname: Nuechterlein
authors.affiliation: University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Diana O
authors.initials: DO
authors.lastname: Perkins
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Nirali
authors.initials: N
authors.lastname: Kotowsky
authors.affiliation: Greater Cincinnati Behavioral Health Services, 1501 Madison Road, Walnut Hills, OH 45206, USA.
authors.forename: Tracey G
authors.initials: TG
authors.lastname: Skale
authors.affiliation: University of California, Berkeley, CA, USA.
authors.forename: Lonnie R
authors.initials: LR
authors.lastname: Snowden
authors.affiliation: University of Florida, Gainesville, FL 32611, USA.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Tandon
authors.affiliation: Yale University/Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA.
authors.forename: Cenk
authors.initials: C
authors.lastname: Tek
authors.affiliation: University of Texas, San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.
authors.forename: Dawn
authors.initials: D
authors.lastname: Velligan
authors.affiliation: University of California, San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143, USA.
authors.forename: Sophia
authors.initials: S
authors.lastname: Vinogradov
authors.affiliation: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Cedric
authors.initials: C
authors.lastname: O'Gorman
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D017028:Caregivers / Q000706:statistics & numerical data; D015897:Comorbidity; D017281:Cost of Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000628:therapy; D011788:Quality of Life; D012042:Registries; D012559:Schizophrenia / Q000453:epidemiology* / Q000628:therapy*; D012720:Severity of Illness Index; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology
chemical_list: D014150:Antipsychotic Agents
keywords: Disease burden; Disease characteristics; Functioning; Registry; Schizophrenia