title: Vitamin D insufficiency and deficiency in pediatric renal transplant recipients.
abstract: Vitamin D deficiency is prevalent in the pediatric CKD population. Recognizing that renal transplant recipients have CKD, we assessed the prevalence of vitamin D insufficiency and deficiency in pediatric renal transplant recipients, compared to a healthy pediatric population. We prospectively studied 25(OH)D levels in 29 pediatric renal transplant recipients and 45 control patients over one yr. The overall prevalence of vitamin D insufficiency and deficiency was common in both populations, at 76% (95% CI: 61, 87%) in the pediatric renal transplant recipients and 91% (95% CI: 80, 98%) in the control group. In the paired renal transplant samples, the mean 25(OH)D level was 52.3 ± 17.9 nmol/L in the winter and 65.6 ± 18.8 nmol/L in the summer (95% CI diff.: 3.9, 22.7), in keeping with a significant seasonal difference. The mean dietary intake of vitamin D in the renal transplant recipients, assessed by three-day dietary record, was 5.7 μg/day, with a vitamin D intake below the EAR in the majority. We did not find an association between vitamin D intake and 25(OH)D levels in this study, likely due to the low dietary intake of vitamin D within the transplant population, identifying a potential area for intervention and improvement.
authors.affiliation: Department of Pediatrics, B.C. Children's Hospital, Vancouver, BC, Canada.
authors.forename: Kirsten
authors.identifier: http://orcid.org/0000-0003-1892-030X
authors.initials: K
authors.lastname: Ebbert
authors.affiliation: Division of Nephrology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada.
authors.forename: Josephine
authors.initials: J
authors.lastname: Chow
authors.affiliation: Division of Nephrology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Krempien
authors.affiliation: Division of Nephrology, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada.
authors.forename: Mina
authors.initials: M
authors.lastname: Matsuda-Abedini
authors.affiliation: Division of Nephrology, University of British Columbia, BC Children's Hospital, Vancouver, BC, Canada.
authors.forename: Janis
authors.initials: J
authors.lastname: Dionne
mesh_terms: D000293:Adolescent; D001955:British Columbia; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000150:complications* / Q000601:surgery; D012621:Seasons; D066027:Transplant Recipients; D014807:Vitamin D / Q000032:analysis; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D
keywords: 25-hydroxyvitamin D; kidney transplantation; pediatric; recommended dietary allowances; seasons; vitamin D