title: Synthesis of oxazoles by silver catalysed oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides.
abstract: A silver catalysed synthesis of oxazoles by the oxidative decarboxylation-cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(II) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.
authors.affiliation: College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, P. R. China. aiwenlei@whu.edu.cn.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Ma
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Yan
authors.forename: Changliang
authors.initials: C
authors.lastname: Bian
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Zhang
authors.forename: Mengfan
authors.initials: M
authors.lastname: Wang
authors.forename: Xinlong
authors.initials: X
authors.lastname: Gao
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D003653:Decarboxylation; D007651:Keto Acids / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*
chemical_list: D003486:Cyanides; D007651:Keto Acids; D010080:Oxazoles; D012834:Silver