title: Strong motion deficits in dyslexia associated with DCDC2 gene alteration.
abstract: Dyslexia is a specific impairment in reading that affects 1 in 10 people. Previous studies have failed to isolate a single cause of the disorder, but several candidate genes have been reported. We measured motion perception in two groups of dyslexics, with and without a deletion within the DCDC2 gene, a risk gene for dyslexia. We found impairment for motion particularly strong at high spatial frequencies in the population carrying the deletion. The data suggest that deficits in motion processing occur in a specific genotype, rather than the entire dyslexia population, contributing to the large variability in impairment of motion thresholds in dyslexia reported in the literature.
authors.affiliation: Institute of Neuroscience, CNR, 56124 Pisa, Italy.
authors.forename: Guido Marco
authors.initials: GM
authors.lastname: Cicchini
authors.affiliation: Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy, Centre de Recherche de L'Institut Universitaire en Santé Mentale de Québec, Québec, QC G1J 2G3, Canada, Département de Psychiatrie et Neurosciences, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, Canada.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Marino
authors.affiliation: Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, 23842 Bosisio Parini, Lecco, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Mascheretti
authors.affiliation: Nuclear Medicine Department, Vita-Salute San Raffaele University, San Raffaele Hospital, 20132 Milan, Italy, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Perani
authors.affiliation: Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, 56127 Pisa, Italy, and Scientific Institute Stella Maris, 56128 Pisa, Italy concetta@in.cnr.it.
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Morrone
mesh_terms: D000293:Adolescent; D004410:Dyslexia / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009039:Motion Perception / Q000502:physiology*; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D010775:Photic Stimulation / Q000379:methods; D055815:Young Adult
chemical_list: C510451:DCDC2 protein, human; D008869:Microtubule-Associated Proteins
keywords: DCDC2; dyslexia; magnocellular; psychophysics; visual motion