title: Application of Carbon Nanomaterials in Gene Delivery for Endogenous RNA Interference In Vitro and In Vivo.
abstract: Knocking down expression by small interfering RNA (siRNA) has shown high affinity, specificity and potency in silencing target gene sites. For effective endogenous RNA interference (RNAi), proper siRNA delivery vehicles are essential, to take the siRNA inside cells and protect them during the circulation. Carbon nanomaterials (CNMs) have been successfully applied in biomedicine and biosensor based on their ultra-high surface functionalization and nucleic acid molecular loading capacity. Recently, CNMs have drawn considerable research interest and expectation as potential non-viral vectors for siRNA delivery. Here we reviewed the recent application of CNMs in gene delivery for RNAi, mainly about fullerenes, carbon nanotubes (CNTs) and graphene.
authors.forename: Lanying
authors.initials: L
authors.lastname: Li
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wen
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China. huangqing@sinap.ac.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry*; D018014:Gene Transfer Techniques; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*; D034622:RNA Interference; D000067492:RNAi Therapeutics / Q000379:methods*
chemical_list: D002244:Carbon