title: Massive lineage replacements and cryptic outbreaks of Salmonella Typhi in eastern and southern Africa.
abstract: A new large-scale study reports the whole-genome sequences of nearly 2,000 Salmonella enterica serovar Typhi (S. Typhi) strains collected from 63 countries. A recent and dominant multidrug-resistant (MDR) lineage originating from South Asia, which is supplanting a bulk of ancestral drug-sensitive strains, is identified; the success of this lineage is likely driven by plasmid acquisitions and the chromosomal integration of resistance-conferring genes.
authors.affiliation: Institut de Systématique, Evolution, Biodiversité (ISYEB), UMR 7205, CNRS, Muséum National d'Histoire Naturelle (MNHN), Université Pierre et Marie Curie, and Ecole Pratique des Hautes Etudes (EPHE), Sorbonne Universités, Paris Sciences et Lettres, Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Wirth
mesh_terms: D000351:Africa, Eastern / Q000453:epidemiology; D000353:Africa, Southern / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial / Q000235:genetics; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D006801:Humans; D012485:Salmonella typhi / Q000235:genetics*; D014435:Typhoid Fever / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents