title: Vitamin D serum levels are associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture.
abstract: OBJECTIVE
  The aim of this study was to evaluate the association between serum levels of 25(OH) vitamin D3 with midupper arm muscle circumference (MUAMC), handgrip strength and length of hospital stay (LOS) after hip fracture.
  
  
  METHODS
  In total, 102 consecutive patients with hip fracture over the age of 65 were admitted to the orthopedic unit and prospectively evaluated. All of the patients were treated according to specific protocols depending on the type of fracture. Anthropometric measurements and handgrip strength were performed, and blood samples were taken for serum biochemistry and 25(OH) vitamin D3 analysis within the first 72 h of admission. All of the patients were followed during their hospital stay, and the length of stay was recorded.
  
  
  RESULTS
  Of the patients, two were excluded because of pathologic fractures. In total, 100 patients with a mean age of 80 ± 7 y were included in the analysis. Among these patients, 73% were female, and 37% had vitamin D deficiency. The median LOS was 7 (5-11) d. Patients with vitamin D deficiency had lower handgrip strength in univariate analysis. In the multiple linear regression analysis with robust standard error, serum vitamin D levels adjusted by age and sex were associated with handgrip strength but not with MUAMC and LOS after hip fracture.
  
  
  CONCLUSIONS
  In conclusion, vitamin D serum levels were associated with handgrip strength but not with muscle mass or length of hospital stay after hip fracture.
authors.affiliation: Surgery and Orthopedic Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: David Nicoletti
authors.initials: DN
authors.lastname: Gumieiro
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Bruna Paola
authors.initials: BP
authors.lastname: Murino Rafacho
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Bruna Letícia
authors.initials: BL
authors.lastname: Buzati Pereira
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Karelin Alvisi
authors.initials: KA
authors.lastname: Cavallari
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Suzana Erico
authors.initials: SE
authors.lastname: Tanni
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Paula Schmidt
authors.initials: PS
authors.lastname: Azevedo
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Bertha Furlan
authors.initials: BF
authors.lastname: Polegato
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Leonardo Antonio
authors.initials: LA
authors.lastname: Mamede Zornoff
authors.affiliation: Surgery and Orthopedic Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Daniel Innocenti
authors.initials: DI
authors.lastname: Dinhane
authors.affiliation: Surgery and Orthopedic Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Kandir Genésio
authors.initials: KG
authors.lastname: Innocenti Dinhane
authors.affiliation: Surgery and Orthopedic Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Gilberto José
authors.initials: GJ
authors.lastname: Cação Pereira
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
authors.forename: Sergio Alberto Rupp
authors.initials: SA
authors.lastname: de Paiva
authors.affiliation: Internal Medicine Department, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil. Electronic address: Minicucci@fmb.unesp.br.
authors.forename: Marcos Ferreira
authors.initials: MF
authors.lastname: Minicucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001132:Arm / Q000033:anatomy & histology; D002112:Calcifediol / Q000097:blood*; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006620:Hip Fractures / Q000097:blood*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D018482:Muscle, Skeletal / Q000502:physiology*; D012307:Risk Factors; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D002112:Calcifediol
keywords: Dynapenia; Hip fracture; Sarcopenia; Vitamin D