title: Oligodendrocyte generation during mouse development.
abstract: Oligodendrocytes (OLs) are glial cells, which generate myelin in the central nervous system. Their interesting developmental features attract many neurobiologists eager to study cell differentiation, gene expression regulation, or dynamic morphogenesis. Their primary role in protecting the axons has major impacts in the medical research field: in multiple sclerosis, a demyelinating disease in which remyelination is blocked. Oligodendrogenesis is involved in higher brain function including motor skill learning and cognitive function. Here, we review advances in the research on OL development and highlight areas where questions remain to be answered in both developmental biology and neurobiology related aspects.
authors.affiliation: Division of Neurobiology and Anatomy, Niigata University, Niigata, Japan.
authors.forename: Hirohide
authors.initials: H
authors.lastname: Takebayashi
authors.affiliation: Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ikenaka
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development* / Q000502:physiology; D051379:Mice; D009836:Oligodendroglia / Q000502:physiology*; D013116:Spinal Cord / Q000254:growth & development* / Q000502:physiology
keywords: myelin; oligodendrocyte; reymyelination