title: The toxicity of a new disinfection by-product, 2,2-dichloroacetamide (DCAcAm), on adult zebrafish (Danio rerio) and its occurrence in the chlorinated drinking water.
abstract: The detection method of 2,2-dichloroacetamide (DCAcAm), a new disinfection by-product (DBP) in chlorinated drinking water, was established using a gas chromatograph coupled with a micro-electron capture detector. The chlorinated water samples were taken from ten drinking water treatment plants around Yangtze River or Taihu Lake in China. The concentration of DCAcAm was detected ranging from 0.5 to 1.8μg/L in the waterworks around Yangtze River, and 1.5-2.6μg/L around Taihu Lake. The toxicity of DCAcAm on adult zebrafish was assessed by investigating the metabolism damage with multiple metabolic biomarkers and the accumulation capability with bio-concentration factor. The results showed that DCAcAm could cause the acute metabolism damage and was easily accumulated in zebrafish, and should be extremely cautioned.
authors.affiliation: Ministry of Education, Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Yu
authors.affiliation: Ministry of Education, Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Hohai University, Nanjing 210098, PR China; College of Environment, Hohai University, Nanjing 210098, PR China. Electronic address: hit_lintao@163.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.affiliation: College of Environment, Hohai University, Nanjing 210098, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: College of Environment, Hohai University, Nanjing 210098, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tao
mesh_terms: D000081:Acetamides / Q000032:analysis* / Q000633:toxicity*; D000818:Animals; D002681:China; D004203:Disinfection; D060766:Drinking Water / Q000032:analysis*; D004784:Environmental Monitoring; D054879:Halogenation; D060106:Lakes; D045483:Rivers; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000633:toxicity*; D018508:Water Purification / Q000379:methods; D015027:Zebrafish
chemical_list: D000081:Acetamides; D060766:Drinking Water; D014874:Water Pollutants, Chemical; C032619:2,2-dichloroacetamide
keywords: DCAcAm; Disinfection by-product; Drinking water; Toxicity; Zebrafish