title: Monitoring of the antiviral potential of bee venom and wax extracts against Adeno-7 (DNA) and Rift Valley fever virus (RNA) viruses models.
abstract: This study monitored the antiviral potential of bee venom and four wax extracts, ethanol white and black beeswax (EWW/EBW) and acetone white and black beeswax (AWW/ABW) extracts. Two different virus models namely Adeno-7 as DNA model and RVFV as RNA virus models. End point calculation assay was used to calculate virus depletion titer. The depletion of viral infectivity titer of ABW to Adeno-7 virus showed strong antiviral activity recorded a depletion of viral infectivity titer (1.66 log (10)/ ml) that gave equal action with bee venom and more than interferon IFN (1 log (10)/ ml). On the other hand, antiviral activity of EBW showed a moderate potential, while AWW showed no antiviral activity. Finally EWW showed synergetic activity against Adeno-7 virus activity. Thus, activity of wax extracts to RVFV was arranged in order of IFN bee venom > AWW & EBW > EWW and ABW recorded 3.34, 0.65, 0.5, 0.34 respectively. It is the first time to study the beeswax effect against DNA and RNA virus' models; acetone black beeswax recorded a depletion titer 1.66 log (10)/ml.
authors.forename: Mostafa I
authors.initials: MI
authors.lastname: Hassan
authors.forename: Aly F
authors.initials: AF
authors.lastname: Mohamed
authors.forename: Moner A
authors.initials: MA
authors.lastname: Amer
authors.forename: Kotb M
authors.initials: KM
authors.lastname: Hammad
authors.forename: Saber A
authors.initials: SA
authors.lastname: Riad
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004267:DNA Viruses / Q000187:drug effects*; D012296:Rift Valley fever virus / Q000187:drug effects*; D014709:Vero Cells; D014885:Waxes / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D001514:Bee Venoms; D014885:Waxes; C038228:beeswax