title: Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs.
abstract: Doxorubicin (DOX)/CaCO3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specific crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confirms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells.
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Magnabosco
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Di Giosia
authors.affiliation: Department of Material Sciences and Engineering and the Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, 32000, Haifa, Israel.
authors.forename: Iryna
authors.initials: I
authors.lastname: Polishchuk
authors.affiliation: Department of Material Sciences and Engineering and the Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, 32000, Haifa, Israel.
authors.forename: Eva
authors.initials: E
authors.lastname: Weber
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Fermani
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bottoni
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Zerbetto
authors.affiliation: Department of Experimental Oncology, Istituto Europeo di Oncologia, via Adamello 16, 20139Milano, Italy.
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: Pelicci
authors.affiliation: Department of Material Sciences and Engineering and the Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, 32000, Haifa, Israel.
authors.forename: Boaz
authors.initials: B
authors.lastname: Pokroy
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Rapino
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Falini
authors.affiliation: Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum Università di Bologna, via Selmi 2, 40126, Bologna, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Calvaresi
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D004317:Doxorubicin / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning
chemical_list: D004337:Drug Carriers; D004317:Doxorubicin; D002119:Calcium Carbonate
keywords: calcium carbonate; doxorubicin; drug carriers; high-resolution synchrotron powder diffraction; intracrystalline