title: [Research advances on ubiquitin C-terminal hydrolase in oncogenesis and progression].
abstract: By regulating the ubiquitination and deubiquitination of key proteins, ubiquitin-proteasome system mediates a variety of cellular activities. Ubiquitin C-terminal hydrolase (UCH) is a deubiquitinating enzyme which can remove ubiquitin chains at the end of ubiquited proteins. The abnormal expression of UCH has been found in a variety of tumor tissues, indicating that it participates in the process of tumor development. Here we review the characteristics of UCH members and current understanding about the role of UCH in tumor development, and the potential target for cancer treatment.
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Yu
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Wei-lin
authors.initials: WL
authors.lastname: Chen
mesh_terms: D063646:Carcinogenesis; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms; D025801:Ubiquitin; D043222:Ubiquitin Thiolesterase
chemical_list: D025801:Ubiquitin; D043222:Ubiquitin Thiolesterase