title: Prognostic Value of Total Lesion Glycolysis Measured by 18F-FDG-PET/CT in Patients with Colorectal Cancer.
abstract: OBJECTIVE
  [(18)F]Fluorodeoxyglucose positron-emission tomography with computed tomography ((18)F-FDG-PET/CT) was assessed regarding its utility in prediction of outcomes after curative resection of colorectal cancer.
  
  
  METHODS
  Preoperative (18)F-FDG-PET/CT was performed in 325 patients with colorectal cancer. Maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic volume (MV), and total lesion glycolysis (TLG) were measured. Patients were divided into groups using cut-offs for overall survival (OS). (18)F-FDG-PET/CT parameters and other clinicopathological factors were investigated as prognostic factors.
  
  
  RESULTS
  The 5-year OS rates in the low and high SUVmax, SUVmean, MV, and TLG groups were 91.4% and 87.0% (p=0.238), 90.8% and 88.2% (p=0.453), 91.7% and 83.8% (p=0.006), and 92.1% and 70.1% (p=0.001), respectively, indicating poorer outcomes in patients with high MV and TLG. In multivariate analysis, high TLG, age ≥65 years, rectal tumor location, and pN(+) were independent factors predicting a poor prognosis.
  
  
  CONCLUSIONS
  TLG in (18)F-FDG-PET/CT is a prognostic parameter for colorectal cancer after curative resection.
authors.affiliation: Department of Surgery II, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Shimpei
authors.initials: S
authors.lastname: Ogawa
authors.affiliation: Department of Surgery II, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan itabashi@surg2.twmu.ac.jp.
authors.forename: Michio
authors.initials: M
authors.lastname: Itabashi
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Kondo
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Momose
authors.affiliation: Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Sakai
authors.affiliation: Department of Surgery II, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Kameoka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006019:Glycolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; TLG; Total lesion glycolysis; colorectal cancer; prognostic value