title: Decreased dopamine concentrations in the frontal cortex after ablative surgeries in patients exhibiting self-injurious behavior: a microdialysis study.
abstract: The authors examined brain neurochemistry in four patients with mental retardation with self-injurious behaviors after ablative surgeries. The authors found that surgeries in the human limbic system can alter dopamine levels in the frontal cortex over a 36-hour period.
authors.affiliation: From the Dept. of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Haidian, Beijing, China (AL, HZ, ZZ); and the Dept. of Neurosurgery, PLA General Hospital, Hainan Campus, Haikou, Hainan, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Liu
authors.affiliation: From the Dept. of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Haidian, Beijing, China (AL, HZ, ZZ); and the Dept. of Neurosurgery, PLA General Hospital, Hainan Campus, Haikou, Hainan, China.
authors.forename: Anmin
authors.initials: A
authors.lastname: Li
authors.affiliation: From the Dept. of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Haidian, Beijing, China (AL, HZ, ZZ); and the Dept. of Neurosurgery, PLA General Hospital, Hainan Campus, Haikou, Hainan, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: From the Dept. of Neurosurgery, First Affiliated Hospital of PLA General Hospital, Haidian, Beijing, China (AL, HZ, ZZ); and the Dept. of Neurosurgery, PLA General Hospital, Hainan Campus, Haikou, Hainan, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000293:Adolescent; D000328:Adult; D004298:Dopamine / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008137:Longitudinal Studies; D017551:Microdialysis; D018377:Neurotransmitter Agents / Q000378:metabolism; D016728:Self-Injurious Behavior / Q000473:pathology* / Q000601:surgery*; D013238:Stereotaxic Techniques; D013997:Time Factors; D055815:Young Adult
chemical_list: D018377:Neurotransmitter Agents; D004298:Dopamine