title: Protein-induced supramolecular disassembly of amphiphilic polypeptide nanoassemblies.
abstract: Mimicking noncovalent interaction based processes in nature has been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Since the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well. We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
authors.forename: Mijanur Rahaman
authors.initials: MR
authors.lastname: Molla
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
authors.forename: Priyaa
authors.initials: P
authors.lastname: Prasad
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
authors.forename: S
authors.initials: S
authors.lastname: Thayumanavan
mesh_terms: D002256:Carbonic Anhydrases / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D013449:Sulfonamides / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*; D000096926:Benzenesulfonamides
chemical_list: D002256:Carbonic Anhydrases; D010455:Peptides; D013449:Sulfonamides; D013501:Surface-Active Agents; D000096926:Benzenesulfonamides