title: Metabolic Signatures of Human Breast Cancer.
abstract: Metabolomics has emerged as a new discovery tool with the promise of identifying therapeutic targets in cancer. Recent discoveries described essential metabolomic pathways in breast cancer and characterized oncometabolites that drive tumor growth and progression. Oncogenes likeMYCand tumor suppressor genes likeTP53prominently affect breast cancer biology through regulation of cell metabolism and mitochondrial biogenesis. These findings indicate that tumors with dominant mutations could be susceptible to inhibitors of disease metabolism. Moreover, various pre-clinical and clinical studies have linked tumor metabolism to therapeutic response and patient survival. Thus, recent advances suggest that metabolic profiling provides new opportunities to improve outcomes in breast cancer. In this review, we have summarized some of the identified roles of oncometabolites in breast cancer biology and highlight their clinical utility.
authors.affiliation: Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
authors.forename: Prachi
authors.initials: P
authors.lastname: Mishra
authors.affiliation: Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ambs
keywords: Cancer; biomarker; metabolism; prognosis; therapy