title: [Prognostic factors and efficacy of molecular targeted therapy for metastatic clear cell renal cell carcinoma].
abstract: We retrospectively reviewed the medical records of patients with metastatic clear cell renal cell carcinoma who received molecular targeted therapy between 2005 and 2011. Cancer-specific survival was analyzed using the Kaplan-Meier method. Predictors of cancer-specific survival were analyzed using the Cox regression hazards model. A total of 89 patients, consisting of 50 first line patients and 39 patients receiving prior cytokine were included in the analysis. The two-year cancer-specific survival rate of the firstlinegroup was 60.2% and that of theprior cytokinethe rapy group was 62.1%. In univariateanalysis, Karnofsky performance status (KPS)＜80%, time from diagnosis to treatment less than one year, bone metastasis and C-reactive protein (CRP)＞1.3 mg/dl in were statistically significant prognostic factors (p＜0.05). In multivariate analysis, time from diagnosis to treatment less than one year (HR 2.46, 95%CI 1.11-5.82, p＝0.025) and CRP (HR 4.92, 95%CI 2.23-11.3, p＜0.001) were independent prognostic factors. Time from diagnosis to treatment less than one year and CRP were independent prognostic factors in patients who received molecular targeted therapy.
authors.affiliation: The Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Inoue
authors.affiliation: The Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitamura
authors.affiliation: The Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shindo
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yanase
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Noriomi
authors.initials: N
authors.lastname: Miyao
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ito
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hotta
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Takaoki
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Taguchi
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsukawa
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Uehara
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Kunishima
authors.affiliation: Sapporo Medical University Urologic Oncology Consortium.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hotta
authors.affiliation: The Department of Urology, Sapporo Medical University School of Medicine.
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002097:C-Reactive Protein / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein