title: [Prognostic value of clinical and morphological characteristics in radiation and combined treatment for tongue cancer].
abstract: It is now possible to identify several key factors that determine biological characteristics of squamous cell cancer of the head and neck: genes p53, p16, cyclin D1, P13-K/Akt connected with metastasis proteins (proteases, proteins mesenchymal cells, cell adhesion molecules chemokines), angiogenesis factors (VEGF, PDGF, FGF, TGF-alpha and TGF-beta), IL-8; epidermal growth factor receptors. An important role of tumor cells plays microenvironment. Of course the above mentioned is only a small part of the factors that determine the livelihoods and the activity of cancer cells. All of these factors are potential predictors of the effectiveness of radiation and chemoradiation treatment and actively studied in recent decades.
authors.forename: A V
authors.initials: AV
authors.lastname: Boiko
authors.forename: A R
authors.initials: AR
authors.lastname: Gevorkov
authors.forename: L E
authors.initials: LE
authors.lastname: Zavalishina
authors.forename: E A
authors.initials: EA
authors.lastname: Nosova
authors.forename: R N
authors.initials: RN
authors.lastname: Plavnik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042501:Angiogenic Proteins / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy*; D018925:Chemokines / Q000032:analysis; D059248:Chemoradiotherapy; D019938:Cyclin D1 / Q000032:analysis; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009367:Neoplasm Staging; D019869:Phosphatidylinositol 3-Kinases / Q000032:analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D051057:Proto-Oncogene Proteins c-akt / Q000032:analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014062:Tongue Neoplasms / Q000737:chemistry / Q000209:etiology / Q000473:pathology* / Q000532:radiotherapy / Q000628:therapy*; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D042501:Angiogenic Proteins; D014408:Biomarkers, Tumor; D018925:Chemokines; D019938:Cyclin D1; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016209:Interleukin-8; D009363:Neoplasm Proteins; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D016159:Tumor Suppressor Protein p53; C530104:CCND1 protein, human; C000614131:CDKN2A protein, human