title: [Changes of telemetry electrical activity in the infralimbic cortex of morphine-dependent rats with extinguished drug-seeking behavior].
abstract: OBJECTIVE
  To investigate the changes of telemetry electrical activity in the infralimbic cortex (IL) of morphine-dependent rats with extinguished drug-seeking behavior.
  
  
  METHODS
  SD rats were randomly divided into model group and control group and received operations of brain stereotaxic electrode embedding in the IL. The rats in the model group were induced to acquire morphine dependence and then received subsequent extinction training, and the changes of electrical activity in the IL were recorded with a physical wireless telemetry system.
  
  
  RESULTS
  In rats with morphine dependence, the time staying in the white box was significantly longer on days 1 and 2 after withdrawal than that before morphine injection and that of the control rats, but was obviously reduced on days 1 and 2 after extinction training to the control level. Compared with the control group, the morphine-dependent rats on day 2 following withdrawal showed significantly increased β wave and decreased δ wave when they stayed in the white box but significantly increased δ wave and decreased α wave and β wave when they shuttled from the black to the white box. On day 2 of extinction, the model rats, when staying in the white box, showed significantly decreased θ wave compared with that of the control rats group but decreased β wave and θ wave and increased δ wave compared with those in the withdrawal period. When they shuttled from black to white box, the model rats showed decreased δ wave and increased α wave and β wave compared with those in the withdrawal period.
  
  
  CONCLUSIONS
  Morphine-dependent rats have abnormal changes of electrical activity in the IL in drug-seeking extinction to affect their drug-seeking motive and inhibit the expression and maintenance of drug-seeking behaviors.
authors.affiliation: Department of Physiology, Wannan Medical College, Wuhu 241002, China.E-mail: muzisanri520@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Qunwan
authors.initials: Q
authors.lastname: Pan
authors.forename: Zaiman
authors.initials: Z
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
authors.forename: Ran
authors.initials: R
authors.lastname: Yu
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D058999:Drug-Seeking Behavior / Q000502:physiology*; D055724:Electrophysiological Phenomena; D005108:Extinction, Psychological; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013686:Telemetry
chemical_list: D009020:Morphine