title: Protein-Resistant Biodegradable Amphiphilic Graft Copolymer Vesicles as Protein Carriers.
abstract: The protein adsorption and self-assembly behavior of biocompatible graft copolymer, poly(lactide-co-diazidomethyl trimethylene carbonate)-g-poly(ethylene glycol) [P(LA-co-DAC)-g-PEG], were systematically studied. The graft copolymers showed enhanced resistance to non-specific protein adsorption compared with their block copolymer counterparts, indicative of the increased effect of PEG density beyond PEG length. Diverse nanostructures including vesicles can be assembled from the amphiphilic graft copolymers with well-defined nano-sizes. Hemoglobin (Hb), as a model protein, can be entrapped in the formed vesicles and keep the gas-binding capacity. The reduced release rate of Hb from graft copolymer vesicles indicated the relatively stable membrane packing compared with block copolymer counterpart.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.
authors.forename: Lesan
authors.initials: L
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.
authors.forename: Yanxin
authors.initials: Y
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China.
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
authors.affiliation: State Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People's Republic of China.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, ChangChun, 130022, People's Republic of China. ybhuang@ciac.ac.cn.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D004337:Drug Carriers / Q000737:chemistry*; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011091:Polyesters; D011506:Proteins; C000608859:poly(lactide-co-diazidomethyl trimethylene carbonate)-g-poly(ethylene glycol); D011092:Polyethylene Glycols
keywords: graft copolymer; polymersome; protein adsorption; protein carriers