title: Further Evidence Supporting a Parent-of-Origin Effect in Psoriatic Disease.
abstract: OBJECTIVE
  To further explore the "parent-of-origin" effect in a large cohort of well-phenotyped patients with cutaneous psoriasis without arthritis (PsC) and psoriatic arthritis (PsA).
  
  
  METHODS
  Self-reported family history was obtained from PsA patients from Toronto and Newfoundland satisfying the Classification of Psoriatic Arthritis criteria, and PsC patients from Toronto, who were examined by a rheumatologist to exclude PsA. Proportions of probands with paternally and maternally transmitted psoriatic disease were compared by McNemar's and chi-square tests. Baseline clinical and genetic characteristics of probands with paternally and maternally transmitted disease were compared using logistic regression.
  
  
  RESULTS
  A total of 849 probands reported a first-degree relative affected with psoriatic disease (PsC or PsA), of which 532 (63%) reported an affected parent. A significantly larger proportion of probands reported an affected father compared to an affected mother with psoriatic disease (289 [57%] versus 220 [43%], respectively; P = 0.003). This paternal transmission bias was evident in PsA (P = 0.006) and PsC probands, although it did not reach statistical significance in PsC probands (P = 0.20). Furthermore, the proportion of paternal PsC-proband PsA pairs (161 of 214 paternal transmissions [75%]) was significantly larger than maternal PsC-proband PsA pairs (103 of 161 maternal transmissions [64%]) (P = 0.02). Newfoundland probands with paternally transmitted disease had higher HLA-B*08 carriage (P = 0.04) and lower MICA-129Met carriage (P = 0.03). Males had higher HLA-B*38 carriage (P = 0.05) and a higher prevalence of nail lesions (P = 0.01).
  
  
  CONCLUSIONS
  We have provided further epidemiologic evidence of a paternal transmission bias in psoriatic disease.
authors.affiliation: Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Remy A
authors.initials: RA
authors.lastname: Pollock
authors.affiliation: Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Arane
authors.initials: A
authors.lastname: Thavaneswaran
authors.affiliation: Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Fawnda
authors.initials: F
authors.lastname: Pellett
authors.affiliation: Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Vinod
authors.initials: V
authors.lastname: Chandran
authors.affiliation: Centre for Addition and Mental Health, Toronto, Ontario, Canada.
authors.forename: Art
authors.initials: A
authors.lastname: Petronis
authors.affiliation: Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
authors.forename: Proton
authors.initials: P
authors.lastname: Rahman
authors.affiliation: Toronto Western Hospital and University of Toronto, Toronto, Ontario, Canada.
authors.forename: Dafna D
authors.initials: DD
authors.lastname: Gladman
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D010290:Parents