title: Prevalence of orofacial clefts in Korean live births.
abstract: OBJECTIVE
  The aim of this study was to investigate the prevalence of orofacial clefts and identify the characteristics of other birth defects associated with orofacial clefts in Korea.
  
  
  METHODS
  This study used data from the Congenital Anomaly Survey conducted by the Korea Institute for Health and Social Affairs. The survey was conducted on birth defects documented during 2005 to 2006 in 2,348 medical institutes in Korea. This study was performed using data from medical insurance claims of the National Health Insurance Corporation. The prevalence of orofacial clefts was defined as the number of cases per 10,000 live births.
  
  
  RESULTS
  Among the 883,184 live births, 25,335 infants had birth defects, which included 980 infants with orofacial clefts. The prevalence of total orofacial clefts in the total live births was 11.09 per 10,000, accounting for 3.9% of all birth defects. The most common orofacial cleft was cleft palate only (n=492), followed by cleft lip only (n=245) and cleft lip with cleft palate (n=243), with prevalence rates of 5.57, 2.77, 2.75 per 10,000 live births, respectively. While malformations of the circulatory system; digestive system; eyes, ears, face, and neck; and musculoskeletal system were most frequently encountered among infants with a cleft lip with or without a cleft palate, anomalies of most organ systems were notably observed among infants with cleft palate only.
  
  
  CONCLUSIONS
  The prevalence of orofacial clefts in Korea was similar or slightly lower than that of other countries. This study informs present status of orofacial clefts and gives baseline data to lay the foundation stone for Korea's registry system of orofacial clefts.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Chung Won
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sun Mi
authors.initials: SM
authors.lastname: Hwang
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: You Sun
authors.initials: YS
authors.lastname: Lee
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Min-A
authors.initials: MA
authors.lastname: Kim
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Kyung
authors.initials: K
authors.lastname: Seo
keywords: Cleft lip; Cleft palate; Korea; Orofacial clefts; Prevalence