title: Does lower urinary tract status affect renal transplantation outcomes in children?
abstract: BACKGROUND
  Lower urinary tract dysfunction (LUTD), an important cause of end stage renal disease (ESRD) in children, can adversely affect renal graft survival. We compared renal transplant patients with LUTD as primary renal disease to those without LUTD.
  
  
  METHODS
  The data of 60 children who underwent renal transplantation (RTx) between 2000 and 2012 were retrospectively reviewed. All patients with LUTD were evaluated with urodynamic tests preoperatively; 15 patients required clean intermittent catheterization and 9 patients underwent augmentation cystoplasty before RTx.
  
  
  RESULTS
  There were 25 children with LUTD. The mean follow-up for LUTD (+) and LUTD (-) groups were 63 (22-155) and 101 months (14-124), and graft survival were 76% for LUTD (+) and 80% for LUTD (-), respectively (P = .711). On the other hand, creatinine levels at last follow-up were significantly higher in the LUTD (+) group (1.3 ± 0.3 mg/dL vs 0.96 ± 0.57 mg/dL, P < .001). Infectious complications and postoperative urinary tract infection incidences were also higher in the LUTD (+) group (68% vs 25.7%, P = .002 and 60% vs 11.4%, P < .01).
  
  
  CONCLUSIONS
  UTI is significantly higher after kidney transplantation in patients with LUTD. Despite the higher risk of UTI, renal transplantation can be performed safely in those patients with careful patient selection, preoperative management, and close postoperative follow-up. Restoration of good bladder function is the key factor in the success of kidney transplantation in those patients.
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: ftuncayaki@yahoo.com.
authors.forename: F T
authors.initials: FT
authors.lastname: Aki
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: A M
authors.initials: AM
authors.lastname: Aydin
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: H S
authors.initials: HS
authors.lastname: Dogan
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: M I
authors.initials: MI
authors.lastname: Donmez
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Erkan
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Hacettepe University, School of Medicine, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Duzova
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, Hacettepe University, School of Medicine, Ankara, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Topaloglu
authors.affiliation: Department of Urology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tekgul
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000209:etiology