title: Organocatalytic asymmetric intramolecular aza-Henry reaction: facile synthesis of trans-2,3-disubstituted tetrahydroquinolines.
abstract: An enantio- and diastereoselective organocatalytic intramolecular aza-Henry (nitro-Mannich) reaction has been developed. The trans-2-aryl-3-nitro-tetrahydroquinoline products are obtained in high yields and in good enantioselectivities with a bifunctional tertiary amine-thiourea catalyst. Excellent enantioselectivities were obtained after single recrystallization of some products.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, India. span@iitg.ernet.in.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Maity
authors.forename: Subhas Chandra
authors.initials: SC
authors.lastname: Pan
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D003460:Crystallization; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
chemical_list: D000588:Amines; D011804:Quinolines; C542964:1,2,3,4-tetrahydroquinoline; D013890:Thiourea