title: Post-transplant Hyperuricemıa as a Cardıovascular Risk Factor.
abstract: OBJECTIVE
  Uric acid is known to impair endothelial cell function and to stimulate the development of renal interstitial fibrosis. The aim of this study was to evaluate the association between first-year hyperuricemia with graft dysfunction and the development of cardiovascular risk disorders in renal transplant recipients.
  
  
  METHODS
  One hundred kidney transplant recipients (31 female, 45.9 ± 9.6 post-transplantation months) with normal graft functions were enrolled. The clinical biochemical parameters in the first post-transplantation year were retrospectively recorded and searched for the predictive value in yearly determined graft function and association with cross-sectionally analyzed cardiovascular parameters, including body composition analyses, ambulatory blood pressure monitoring data, and pulse wave velocity. Hyperuricemia was defined as an uric acid level of ≥ 6.5 mg/dL that persisted for at least 2 consecutive tests.
  
  
  RESULTS
  One year after transplantation, 37% of subjects had hyperuricemia. According to cross-sectional data, sagittal abdominal diameter (P = .002) and hip circumferences (P = .013) were significantly higher in hyperuricemic patients than in normouricemic ones. Hyperuricemic patients had higher fat (P = .014) and muscle mass (P = .016) than normouremic patients. Hyperuricemic patients had significantly higher mean systolic BP (P = .044) than normouremic patients. Hyperuricemic patients had significantly higher pulse wave velocity levels (P = .0001) and left ventricular mass index (P = .044) than normouremic patients. The yearly decline in estimated glomerular filtration rate levels was significantly higher in hyperuricemic patients (P = .0001) than in normouricemic ones.
  
  
  CONCLUSIONS
  Post-transplantation hyperuricemia is associated with hypertension, arterial stiffness, and dyslipidemia; it should be accepted not only as a marker for renal allograft dysfunction but also as a cardiovascular risk factor in renal transplant recipients.
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey. Electronic address: mehtap94@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Erkmen Uyar
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sezer
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Bal
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Guliyev
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Tutal
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Kulah
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Genctoy
authors.affiliation: Department of Nephrology, Baskent University, Antalya, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ozdemir Acar
authors.affiliation: Department of General Surgery, Baskent University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous