title: Emerging concepts regarding pannexin 1 in the vasculature.
abstract: Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are not specific for Panx1 and have additional effects on other proteins. Therefore, molecular tools, such as RNA interference and knockout animals, are needed to demonstrate the role of pannexins in various cellular functions. This review focuses on the known roles of Panx1 related to purinergic signalling in the vasculature focusing on post-translational modifications and channel gating mechanisms that may participate in the regulated release of ATP.
authors.affiliation: *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
authors.forename: Miranda E
authors.initials: ME
authors.lastname: Good
authors.affiliation: *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
authors.forename: Daniela
authors.initials: D
authors.lastname: Begandt
authors.affiliation: *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
authors.forename: Leon J
authors.initials: LJ
authors.lastname: DeLalio
authors.affiliation: *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Keller
authors.affiliation: ‡Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, U.S.A.
authors.forename: Marie
authors.initials: M
authors.lastname: Billaud
authors.affiliation: *Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, U.S.A.
authors.forename: Brant E
authors.initials: BE
authors.lastname: Isakson
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017630:Connexins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000254:growth & development / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D034622:RNA Interference; D011983:Receptors, Purinergic / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017630:Connexins; D009419:Nerve Tissue Proteins; C492764:PANX1 protein, human; D011983:Receptors, Purinergic; D000255:Adenosine Triphosphate