title: Structural and functional interactions within ryanodine receptor.
abstract: The ryanodine receptor/Ca2+ release channel plays a pivotal role in skeletal and cardiac muscle excitation-contraction coupling. Defective regulation leads to neuromuscular disorders and arrhythmogenic cardiac disease. This mini-review focuses on channel regulation through structural intra- and inter-subunit interactions and their implications in ryanodine receptor pathophysiology.
authors.affiliation: *Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: Monika
authors.initials: M
authors.lastname: Seidel
authors.affiliation: *Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: F Anthony
authors.initials: FA
authors.lastname: Lai
authors.affiliation: *Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Heath Park, Cardiff CF14 4XN, U.K.
authors.forename: Spyros
authors.initials: S
authors.lastname: Zissimopoulos
mesh_terms: D002118:Calcium / Q000737:chemistry; D020013:Calcium Signaling / Q000235:genetics; D006331:Heart Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009119:Muscle Contraction / Q000235:genetics*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D009468:Neuromuscular Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium