title: U-shaped fiber-optic ATR sensor enhanced by silver nanoparticles for continuous glucose monitoring.
abstract: An implantable U-shaped fiber ATR sensor enhanced by silver nanoparticles on cylindrical surface was presented for continuous glucose monitoring to overcome the drawbacks of traditional glucose sensing technique based on enzyme electrodes. A U-shaped structure was addressed to increase effective optical length at limited implantable space to enhance the sensitivity of fiber ATR sensor. A novel method to fabricate silver nanoparticles on cylindrical surface of U-shaped fiber ATR sensor based on chemical reduction of its silver halide material directly without any preliminary nanoparticles synthesis and following covalent bond or self-assembly was proposed. Five glucose absorption wavelengths in the mid-infrared band were employed for specific glucose monitoring. The experimental results indicate that the sensitivity and resolution of the silver-nanoparticle-enhanced U-shaped fiber-optic ATR sensor are approximately three times those of a conventional one. The high sensitivity and low-noise performance makes it promising for in vivo glucose monitoring in the future clinical applications.
authors.affiliation: State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, 92 Weijin Rd., Nankai District, Tianjin 300072, PR China. Electronic address: dchli@tju.edu.cn.
authors.forename: Dachao
authors.initials: D
authors.lastname: Li
authors.affiliation: Temperature Laboratory, Tianjin Institute of Metrological Supervision Testing, 4 Keyanxi Rd., Nankai District, Tianjin 300192, PR China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Yu
authors.affiliation: Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, 92 Weijin Rd., Nankai District, Tianjin 300072, PR China.
authors.forename: Changyue
authors.initials: C
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, 92 Weijin Rd., Nankai District, Tianjin 300072, PR China.
authors.forename: Chongwei
authors.initials: C
authors.lastname: Zou
authors.affiliation: Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University, 92 Weijin Rd., Nankai District, Tianjin 300072, PR China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, 92 Weijin Rd., Nankai District, Tianjin 300072, PR China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Xu
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation*; D004867:Equipment Design; D005336:Fiber Optic Technology / Q000295:instrumentation*; D005947:Glucose / Q000032:analysis*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D055100:Optical Fibers; D019736:Prostheses and Implants; D012834:Silver / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D012834:Silver; D005947:Glucose
keywords: Continuous glucose monitoring; Cylindrical surface; Fiber-optic ATR sensor; Silver nanoparticle; U-shaped structure