title: Correlation of Lower Concentrations of Hydrogen Sulfide with Activation of Protein Kinase CβII in Uremic Accelerated Atherosclerosis Patients.
abstract: BACKGROUND
  Hydrogen sulfide (H 2 S) plays a protective role in chronic hemodialysis (CHD) patients. In this study, we further investigate the relationship between H 2 S and conventional protein kinase CβII (cPKCβII) in CHD patients with uremic accelerated atherosclerosis (UAAS).
  
  
  METHODS
  A total of 30 healthy people, 30 CHD patients without AS and 30 CHD patients with AS (CHD + AS) were studied. Plasma H 2 S was measured with a sulfide sensitive electrode, and cPKCβII membrane translocation was detected by Western blotting.
  
  
  RESULTS
  Plasma H 2 S in CHD + AS group was significantly lower than that in CHD patients. cPKCβII membrane translocation in CHD + AS group increased significantly compared with CHD group. Plasma H 2 S concentration was negatively correlated with cPKCβII membrane translocation in CHD + AS patients.
  
  
  CONCLUSIONS
  These findings suggest a possible linkage between H 2 S metabolism and cPKCβII activation, which may contribute to the development of UAAS in CHD patients.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Su-Juan
authors.initials: SJ
authors.lastname: Feng
authors.affiliation: Institute of Uro-Nephrology, Beijing Chao-Yang Hospital, Capital Medical University; Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Nephrology Faculty, Capital Medical University, Beijng 100020, China.
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhang
authors.forename: Shi-Xiang
authors.initials: SX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000201:enzymology* / Q000378:metabolism; D015153:Blotting, Western; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D006435:Renal Dialysis; D055815:Young Adult
chemical_list: D011493:Protein Kinase C; D006862:Hydrogen Sulfide