title: Gas-saturated solution process to obtain microcomposite particles of alpha lipoic acid/hydrogenated colza oil in supercritical carbon dioxide.
abstract: Alpha lipoic acid (ALA), an active substance in anti-aging products and dietary supplements, need to be masked with an edible polymer to obscure its unpleasant taste. However, the high viscosity of the ALA molecules prevents them from forming microcomposites with masking materials even in supercritical carbon dioxide (scCO2). Therefore, the purpose of this study was to investigate and develop a novel production method for microcomposite particles for ALA in hydrogenated colza oil (HCO). Microcomposite particles of ALA/HCO were prepared by using a novel gas-saturated solution (PGSS) process in which the solid-dispersion method is used along with stepwise temperature control (PGSS-STC). Its high viscosity prevents the formation of microcomposites in the conventional PGSS process even under strong agitation. Here, we disperse the solid particles of ALA and HCO in scCO2 at low temperatures and change the temperature stepwise in order to mix the melted ALA and HCO in scCO2. As a result, a homogeneous dispersion of the droplets of ALA in melted HCO saturated with CO2 is obtained at high temperatures. After the rapid expansion of the saturated solution through a nozzle, microcomposite particles of ALA/HCO several micrometers in diameter are obtained.
authors.affiliation: a Department of Chemical Engineering, Faculty of Engineering , Fukuoka University , Fukuoka , Japan .
authors.forename: Kenji
authors.initials: K
authors.lastname: Mishima
authors.affiliation: b Central Research & Development Laboratory , FANCL Corporation , Yokohama , Japan .
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Honjo
authors.affiliation: a Department of Chemical Engineering, Faculty of Engineering , Fukuoka University , Fukuoka , Japan .
authors.forename: Tanjina
authors.initials: T
authors.lastname: Sharmin
authors.affiliation: a Department of Chemical Engineering, Faculty of Engineering , Fukuoka University , Fukuoka , Japan .
authors.forename: Shota
authors.initials: S
authors.lastname: Ito
authors.affiliation: a Department of Chemical Engineering, Faculty of Engineering , Fukuoka University , Fukuoka , Japan .
authors.forename: Ryo
authors.initials: R
authors.lastname: Kawakami
authors.affiliation: a Department of Chemical Engineering, Faculty of Engineering , Fukuoka University , Fukuoka , Japan .
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kato
authors.affiliation: c Department of Electronics Engineering and Computer Science, Faculty of Engineering .
authors.forename: Makoto
authors.initials: M
authors.lastname: Misumi
authors.affiliation: c Department of Electronics Engineering and Computer Science, Faculty of Engineering .
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suetsugu
authors.affiliation: d Department of Electrical Engineering, Faculty of Engineering , and.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Orii
authors.affiliation: e Department of Neuropharmacology, Faculty of Pharmaceutical Sciences , Fukuoka University , Fukuoka , Japan .
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawano
authors.affiliation: e Department of Neuropharmacology, Faculty of Pharmaceutical Sciences , Fukuoka University , Fukuoka , Japan .
authors.forename: Keiichi
authors.initials: K
authors.lastname: Irie
authors.affiliation: e Department of Neuropharmacology, Faculty of Pharmaceutical Sciences , Fukuoka University , Fukuoka , Japan .
authors.forename: Kazunori
authors.initials: K
authors.lastname: Sano
authors.affiliation: e Department of Neuropharmacology, Faculty of Pharmaceutical Sciences , Fukuoka University , Fukuoka , Japan .
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
authors.affiliation: f Department of Applied Chemistry, Faculty of Engineering , Oita University , Oita-Shi , Japan , and.
authors.forename: Takunori
authors.initials: T
authors.lastname: Harada
authors.affiliation: g Institute for General Education, University of Hyogo , Hyogo , Japan.
authors.forename: Mikio
authors.initials: M
authors.lastname: Ouchi
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D006865:Hydrogenation; D008863:Microspheres; D010316:Particle Size; D019999:Pharmaceutical Solutions / Q000032:analysis / Q000138:chemical synthesis / Q000493:pharmacokinetics; D008063:Thioctic Acid / Q000032:analysis / Q000138:chemical synthesis* / Q000493:pharmacokinetics
chemical_list: D019999:Pharmaceutical Solutions; D002245:Carbon Dioxide; D008063:Thioctic Acid
keywords: Colza oil; PGSS; composite particle; lipoic acid; supercritical carbon dioxide