title: Animal models of adrenocortical tumorigenesis.
abstract: This comparative review highlights animal models of adrenocortical neoplasia useful either for mechanistic studies or translational research. Three model species-mouse, ferret, and dog-are detailed. The relevance of each of these models to spontaneous and inherited adrenocortical tumors in humans is discussed.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, Utrecht 3508 TD, The Netherlands.
authors.forename: Sara
authors.initials: S
authors.lastname: Galac
authors.affiliation: Departments of Pediatrics and Developmental Biology, St. Louis Children's Hospital, Washington University, 660 South Euclid Avenue, Box 8208, St Louis, MO 63110, USA. Electronic address: wilson_d@wustl.edu.
authors.forename: David B
authors.initials: DB
authors.lastname: Wilson
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D018246:Adrenocortical Adenoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism; D003480:Cushing Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D004354:Drug Screening Assays, Antitumor; D005289:Ferrets; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental
keywords: Adrenal cortex; Cushing syndrome; Dog; Endocrine tumor; Ferret; Gonadectomy; Mouse