title: Living-donor Kidney Transplantation: Predictive Factors and Impact on Post-transplant Outcome.
abstract: Renal transplantation from living donors represents a valuable opportunity for patients with end-stage renal disease due to short- and long-term outcomes. Nevertheless, it requires that a detailed set of conditions be considered for donor and recipient selection, with possible implications arising from these criteria in the post-transplant outcome. The present work aims to study demographic and clinical characteristics of donors and kidney recipients that predict post-transplantation outcomes after living donor kidney transplantation. With this aim, all patients who underwent donor nephrectomy and living donor transplantation between January 2012 and December 2013 were selected. Demographics, medical comorbidities, and postoperative outcomes were transcribed from electronic patient records. Linear and logistic regressions were applied for data analysis. The study sample consists of 40 patients who underwent living donor kidney transplantation. The presence of peripheral arterial disease and the etiology of end-stage renal disease were the only pretransplant variables that seem to independently predict hospitalization time. Simultaneously, the occurrence of urorenal and infectious complications had a statistically significant correlation with hospitalization time. Additionally, the incidence of cardiovascular complications was correlated with surgical reinterventions at a significant level. The results suggest that careful selection of the donor and the kidney recipient appears to be a prerequisite for a successful transplantation in vivo.
authors.affiliation: Centro Hospitalar do Porto, Service of Anaesthesiology, Porto, Portugal. Electronic address: amfariaaraujo@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Araújo
authors.affiliation: Centro Hospitalar do Porto, Service of Anaesthesiology, Porto, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.affiliation: Centro Hospitalar do Porto, Service of Anaesthesiology, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Guimarães
authors.affiliation: Centro Hospitalar do Porto, Service of Anaesthesiology, Porto, Portugal; Department of Sciences and Technology, Universidade Aberta, Del. Porto, Porto, Portugal.
authors.forename: C S
authors.initials: CS
authors.lastname: Nunes
authors.affiliation: Centro Hospitalar do Porto, Service of Anaesthesiology, Porto, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Casal
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D050377:Cold Ischemia / Q000706:statistics & numerical data; D005260:Female; D006331:Heart Diseases; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D052096:Warm Ischemia / Q000706:statistics & numerical data