title: A genomewide association mapping study using ultrasound-scanned information identifies potential genomic regions and candidate genes affecting carcass traits in Nellore cattle.
abstract: The aim of this study was to identify candidate genes and genomic regions associated with ultrasound-derived measurements of the rib-eye area (REA), backfat thickness (BFT) and rumpfat thickness (RFT) in Nellore cattle. Data from 640 Nellore steers and young bulls with genotypes for 290 863 single nucleotide polymorphisms (SNPs) were used for genomewide association mapping. Significant SNP associations were explored to find possible candidate genes related to physiological processes. Several of the significant markers detected were mapped onto functional candidate genes including ARFGAP3, CLSTN2 and DPYD for REA; OSBPL3 and SUDS3 for BFT; and RARRES1 and VEPH1 for RFT. The physiological pathway related to lipid metabolism (CLSTN2, OSBPL3, RARRES1 and VEPH1) was identified. The significant markers within previously reported QTLs reinforce the importance of the genomic regions, and the other loci offer candidate genes that have not been related to carcass traits in previous investigations.
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: M H A
authors.initials: MH
authors.lastname: Santana
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.|Centre for Genetic Improvement of Livestock, University of Guelph, Guelph, ON, Canada.|Beef Improvement Opportunties (BIO), Guelph, ON, Canada.
authors.forename: R V
authors.initials: RV
authors.lastname: Ventura
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.
authors.forename: Y T
authors.initials: YT
authors.lastname: Utsunomiya
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.|GenSys Consultores Associados S/C Ltda, Porto Alegre, Brazil.
authors.forename: H H R
authors.initials: HH
authors.lastname: Neves
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: P A
authors.initials: PA
authors.lastname: Alexandre
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: G A
authors.initials: GA
authors.lastname: Oliveira Junior
authors.affiliation: Empresa Brasileira de Pesquisa Agropecuária, CNPGC/EMBRAPA, Campo Grande, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Gomes
authors.affiliation: Empresa Brasileira de Pesquisa Agropecuária, CNPGC/EMBRAPA, Campo Grande, Brazil.
authors.forename: M N
authors.initials: MN
authors.lastname: Bonin
authors.affiliation: Escola Superior de Agricultura Luiz de Queiroz, USP, Piracicaba, Brazil.
authors.forename: L L
authors.initials: LL
authors.lastname: Coutinho
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, UNESP, Jaboticabal, Brazil.
authors.forename: J F
authors.initials: JF
authors.lastname: Garcia
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: S L
authors.initials: SL
authors.lastname: Silva
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: H
authors.initials: H
authors.lastname: Fukumasu
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: P R
authors.initials: PR
authors.lastname: Leme
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos - USP, Pirassununga, Brazil.
authors.forename: J B S
authors.initials: JB
authors.lastname: Ferraz
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000818:Animals; D050218:Body Fat Distribution / Q000662:veterinary*; D002417:Cattle / Q000235:genetics*; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D005838:Genotype; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D000069466:Red Meat; D015398:Signal Transduction; D014463:Ultrasonography
chemical_list: D005819:Genetic Markers
keywords: Bos indicus; candidate genes; fat thickness; genomewide association studies; single nucleotide polymorphisms; ultrasonography