title: Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming.
abstract: Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells (iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.
authors.forename: Wanqiu
authors.initials: W
authors.lastname: Chen
authors.forename: David J
authors.initials: DJ
authors.lastname: Baylink
authors.forename: K-H William
authors.initials: KH
authors.lastname: Lau
authors.affiliation: Division of Regenerative Medicine, Department of Medicine, Loma Linda University. 11234 Anderson Street, MC1528, Loma Linda, CA 92350, USA. xzhang@llu.edu.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Zhang
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D001773:Blood Cells / Q000166:cytology / Q000637:transplantation*; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D065150:Cellular Reprogramming / Q000235:genetics*; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*