title: The optimal number of offspring per gamete donor.
abstract: Our aim was to create a mathematical basis to calculate the risks for unintended matings of consanguineous half-siblings from a donor in a society with approximately 10 million inhabitants. The Curie-Cohen model for calculation of the risk for consanguineous mating was used. When the number of offspring per donor is limited to 10, then the model gives a yearly risk for consanguineous matings below 1%. Thus 10 offspring gives a risk for consanguineous matings of 0.9% per year, or approximately once in every 100 years. The risk increases exponentially: with 15 offspring it exceeds 2% and with 25 it reaches up above 5%.
authors.affiliation: Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Sydsjö
authors.affiliation: Center for Andrology and Sexual Medicine, Karolinska University Hospital, Stockholm, Sweden.|Department of Medicine, Karolinska Instituet, Huddinge, Stockholm, Sweden.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Kvist
authors.affiliation: Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Bladh
authors.affiliation: Swedish Police Authority - National Forensic Centre, Linköping, Sweden.|Department of Computer and Information Science, Linköping University, Linköping, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Nordgaard
mesh_terms: D003241:Consanguinity; D046148:Donor Selection / Q000706:statistics & numerical data*; D005854:Germ Cells; D006801:Humans; D008962:Models, Theoretical; D027724:Reproductive Techniques, Assisted; D012306:Risk; D013548:Sweden
keywords: Number of children; consanguinity; donor; fertility; mathematical model