title: The involvement of uric acid in the pathogenesis of preeclampsia.
abstract: Preeclampsia is a common disorder of human pregnancy and a major cause of worldwide pregnancy-related maternal and neonatal morbidity and mortality. Oxidative stress, angiogenic imbalance, placental ischemia and an inflammatory response have been proposed to play role in the pathogenesis of the disease. Hyperuricemia is a key biochemical feature in preeclampsia with elevated levels of uric acid being diagnosed as early as the 10(th) week of gestation. Traditionally, elevated uric acid levels were considered a result of renal dysfunction known to exist in preeclampsia. The contribution of uric acid in the pathogenesis of preeclampsia is being recently further investigated. We, hereby, review the possible mechanisms by which uric acid contributes to the development of the disease and its complications both on mother and fetus.
authors.affiliation: 4th Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece, 3 M. Iosif Str., 54622 Thessaloniki, Greece. masourasophia@yahoo.gr.
authors.forename: Sophia
authors.initials: S
authors.lastname: Masoura
authors.forename: Kali
authors.initials: K
authors.lastname: Makedou
authors.forename: Theodoros
authors.initials: T
authors.lastname: Theodoridis
authors.forename: Anargyros
authors.initials: A
authors.lastname: Kourtis
authors.forename: Leonidas
authors.initials: L
authors.lastname: Zepiridis
authors.forename: Apostolos
authors.initials: A
authors.lastname: Athanasiadis
mesh_terms: D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid