title: Noninvasive monitoring of peripheral microcirculatory hemodynamics under varying degrees of hypoxia.
abstract: The effect of hypoxia on skin blood flow was examined in anesthetized rabbits during induction of various levels of hypoxia. Peripheral perfusion and oxygenation were monitoring using a combined system (LPT) composed of a laser Doppler flowmeter (LDF), a photoplatysmograph (PPG), and a transcutaneous oxygen tension monitor (tc-PO2). Central blood parameters (PaO2, HCO3(-), SaO2, pH, and lactate) were measured concomitantly throughout the experiment. A continuous decline was found in both peripheral and central values, depending on the severity of the hypoxia. The results clearly indicate that monitoring peripheral indices with the LPT system enables monitoring changes of vital blood parameters during hypoxia. The system has clinical potential for sensitive and noninvasive monitoring of vital variables during medical procedures in clinics, as well as for homecare for patients with respiratory diseases. Minimizing the system may be useful in various conditions of exposure to low oxygen levels, such as during mountain climbing.
authors.affiliation: Department of Medical Engineering, Afeka Tel Aviv Academic College of Engineering, Tel Aviv, Israel. Electronic address: zehava@afeka.ac.il.
authors.forename: Zehava
authors.initials: Z
authors.lastname: Ovadia-Blechman
authors.affiliation: Department of Medical Engineering, Afeka Tel Aviv Academic College of Engineering, Tel Aviv, Israel.
authors.forename: Aviram
authors.initials: A
authors.lastname: Meilin
authors.affiliation: Department of Exact Sciences, Afeka Tel Aviv Academic College of Engineering, Tel Aviv, Israel.
authors.forename: Neta
authors.initials: N
authors.lastname: Rabin
authors.affiliation: Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Eldar
authors.affiliation: Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Castel
mesh_terms: D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000008:administration & dosage*; D011817:Rabbits; D012122:Ventilators, Mechanical
chemical_list: D010100:Oxygen
keywords: Hypoxia; Laser Doppler flowmetry; Noninvasive monitoring; Peripheral microcirculation; Photoplatysmograph; Transcutaneous oxygen tension