title: Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation.
abstract: BACKGROUND
  The PNPLA3 I148M variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. The I148M variant is associated with many chronic liver diseases. However, its potential association with inflammatory and autoimmune liver diseases has not been established.
  
  
  METHODS
  We systemically reviewed the potential associations of I148M variant with chronic viral hepatitis, autoimmune liver diseases and the outcome of liver transplantation, explored the underlying molecular mechanisms and tried to translate them into more individualized decision-making and personalized medicine.
  
  
  RESULTS
  There were associations between I148M variant and chronic viral hepatitis and autoimmune liver diseases and differential associations of I148M variant in donors and recipients with post-liver transplant outcomes. I148M variant may activate the development of steatosis caused by host metabolic disorders in chronic viral hepatitis, but few researches were found to illustrate the mechanisms in autoimmune liver diseases. The peripherally mediated mechanism (via extrahepatic adipose tissue) may play a principal role in triglyceride accumulation regardless of adiponutrin activity in the graft liver.
  
  
  CONCLUSIONS
  Evidences have shown the associations between I148M variant and mentioned diseases. I148M variant induced steatosis may be involved in the mechanism of chronic viral hepatitis and genetic considered personalized therapies, especially for PSC male patients. It is also crucial to pay attention to this parameter in donor selection and prognosis estimation in liver transplantation.
authors.affiliation: Qingdao Municipal Hospital, Medical College, Qingdao University, Qingdao, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Geng
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, P. R. China.
authors.forename: Yong-Ning
authors.initials: YN
authors.lastname: Xin
authors.affiliation: Qingdao Municipal Hospital, Qingdao University, Qingdao, P. R. China.
authors.forename: Harry Hua-Xiang
authors.initials: HH
authors.lastname: Xia
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, P. R. China.
authors.forename: Man
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Qingdao Municipal Hospital, Medical College, Qingdao University, Qingdao, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Qingdao Municipal Hospital, Medical College, Qingdao University, Qingdao, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Qingdao Municipal Hospital, Medical College, Qingdao University, Qingdao, P. R. China.
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, P. R. China.
authors.forename: Shi-Ying
authors.initials: SY
authors.lastname: Xuan
keywords: Autoimmune Hepatitis; Hepatitis B, Chronic; Hepatitis C, Chronic; Liver Transplantation; PNPLA3; Polymorphism