title: Cytoarchitectonic mapping of the human brain cerebellar nuclei in stereotaxic space and delineation of their co-activation patterns.
abstract: The cerebellar nuclei are involved in several brain functions, including the modulation of motor and cognitive performance. To differentiate their participation in these functions, and to analyze their changes in neurodegenerative and other diseases as revealed by neuroimaging, stereotaxic maps are necessary. These maps reflect the complex spatial structure of cerebellar nuclei with adequate spatial resolution and detail. Here we report on the cytoarchitecture of the dentate, interposed (emboliform and globose) and fastigial nuclei, and introduce 3D probability maps in stereotaxic MNI-Colin27 space as a prerequisite for subsequent meta-analysis of their functional involvement. Histological sections of 10 human post mortem brains were therefore examined. Differences in cell density were measured and used to distinguish a dorsal from a ventral part of the dentate nucleus. Probabilistic maps were calculated, which indicate the position and extent of the nuclei in 3D-space, while considering their intersubject variability. The maps of the interposed and the dentate nuclei differed with respect to their interaction patterns and functions based on meta-analytic connectivity modeling and quantitative functional decoding, respectively. For the dentate nucleus, significant (p < 0.05) co-activations were observed with thalamus, supplementary motor area (SMA), putamen, BA 44 of Broca's region, areas of superior and inferior parietal cortex, and the superior frontal gyrus (SFG). In contrast, the interposed nucleus showed more limited co-activations with SMA, area 44, putamen, and SFG. Thus, the new stereotaxic maps contribute to analyze structure and function of the cerebellum. These maps can be used for anatomically reliable and precise identification of degenerative alteration in MRI-data of patients who suffer from various cerebellar diseases.
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University and JARA-Brain Aachen, Germany ; Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Tellmann
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bludau
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany ; Institute for Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Eickhoff
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Mohlberg
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Minnerop
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organization of the Human Brain, Research Centre Jülich Jülich, Germany ; Cécile and Oskar Vogt Institute of Brain Research, Heinrich Heine University Düsseldorf, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
keywords: SPM Anatomy Toolbox; brain mapping; cerebellar nuclei; cytoarchitecture; human brain atlas