title: [Hypoxic stress as a trigger of multipotent mesenchymal stromal cell activation].
abstract: Multipotent mesenchymal stromal (stem) cells (MSCs) are a heterogeneous cell population of different commitment and is actively involved in the physiological and regenerative tissue remodeling. MSC mobilization from local tissue depots and their activation in the tissue damage foci are the key issues in the study of mechanisms of MSC features. Short-term (up to 72 h) hypoxic stress that is considered as a constitutive feature of the damage foci, may contribute to the activation of MSC potential. This review is analyzed the data on the impact of short hypoxic stress ex vivo on the viability, functional activity of MSCs and possible molecular mechanisms of these effects.
authors.forename: E R
authors.initials: ER
authors.lastname: Andreeva
authors.forename: M V
authors.initials: MV
authors.lastname: Pogodina
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D013312:Stress, Physiological