title: Adipokines as potential prognostic biomarkers in patients with acute knee injury.
abstract: This review considers adipokines as predictive biomarkers for early onset post-traumatic knee osteoarthritis (KOA). Serum concentrations of leptin and resistin can predict radiographic changes and are elevated in early KOA, with higher leptin concentrations independently associated with more severe knee changes. Plasma concentrations of resistin are chronically elevated after injury. Leptin, resistin, chemerin and vistfatin induce catabolic enzymes associated with cartilage degeneration. Available literature on adipokines in post-traumatic KOA pathogenesis suggests that they could contribute to risk prediction of early onset post-traumatic KOA. Further research is needed to further understand the association between adipokines, synovitis and long-term outcomes in this population.
authors.affiliation: a Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .
authors.forename: Stefan
authors.initials: S
authors.lastname: Kluzek
authors.affiliation: b Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences , University of Oxford , Oxford , UK , and.|c MRC Lifecourse Epidemiology Unit , University of Southampton, Southampton General Hospital , Southampton , UK.
authors.forename: Nigel K
authors.initials: NK
authors.lastname: Arden
authors.affiliation: a Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .
authors.forename: Julia
authors.initials: J
authors.lastname: Newton
mesh_terms: D000208:Acute Disease; D054392:Adipokines / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D042241:Early Diagnosis; D006801:Humans; D007718:Knee Injuries / Q000097:blood* / Q000175:diagnosis; D007719:Knee Joint / Q000378:metabolism*; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D013583:Synovial Membrane / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D054392:Adipokines; D015415:Biomarkers
keywords: Bone repair; cytokines; growth factors; inflammatory mediators; obesity/diabetes; osteoarthritis