title: Histopathologic findings in children diagnosed with cow's milk protein allergy.
abstract: BACKGROUND
  Cow's milk protein allergy is the most common cause of food allergy. The challenge test, either open or doubled-blind with a placebo control, is regarded as the criterion standard. Endoscopy and histologic findings are considered a method that can aid in the diagnosis of this entity.
  
  
  OBJECTIVE
  The aim of this study was to describe the histopathologic findings in children suspected of cow's milk protein allergy that were seen at our hospital.
  
  
  METHODS
  A descriptive, observational study was conducted on 116 children clinically suspected of presenting with cow's milk protein allergy that were seen at the Department of Gastroenterology and Nutrition of the Instituto Nacional de Pediatría. Upper endoscopy and rectosigmoidoscopy with biopsies were performed and the findings were described.
  
  
  RESULTS
  Of the 116 patients, 64 (55.17%) were girls and 52 (44.83%) were boys. The rectum was the site with the greatest presence of eosinophils per field in both groups, followed by the duodenum. In general, more than 15 eosinophils were found in 46% of the patients.
  
  
  CONCLUSIONS
  Between 40 and 45% of the cases had the histologic criterion of more than 15 to 20 eosinophils per field and the rectosigmoid colon was the most affected site. Therefore, panendoscopy and rectosigmoidoscopy with biopsy and eosinophil count are suggested.
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: R
authors.initials: R
authors.lastname: Cervantes-Bustamante
authors.affiliation: Servicio de Gastroenterología y Nutrición Pediátrica, Hospital de Alta Especialidad de Ixtapaluca, Secretaría de Salud,, Ixtapaluca, Estado de México, México.
authors.forename: I
authors.initials: I
authors.lastname: Pedrero-Olivares
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México. Electronic address: emtoromonjaraz@gmail.com.
authors.forename: E M
authors.initials: EM
authors.lastname: Toro-Monjaraz
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: P
authors.initials: P
authors.lastname: Murillo-Márquez
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramírez-Mayans
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: E
authors.initials: E
authors.lastname: Montijo-Barrios
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: F
authors.initials: F
authors.lastname: Zárate-Mondragón
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: J
authors.initials: J
authors.lastname: Cadena-León
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: M
authors.initials: M
authors.lastname: Cazares-Méndez
authors.affiliation: Departamento de Gastroenterología y Nutrición Pediátrica, Instituto Nacional de Pediatría, México, D.F., México.
authors.forename: M
authors.initials: M
authors.lastname: López-Ugalde
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000473:pathology*; D007958:Leukocyte Count; D008297:Male; D016269:Milk Hypersensitivity / Q000378:metabolism / Q000473:pathology*; D008894:Milk Proteins / Q000009:adverse effects*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D008894:Milk Proteins
keywords: Alergia a la proteína de la leche de vaca; Cow's milk protein allergy; Endoscopia; Endoscopy; Eosinophils; Eosinófilos; Histology; Histología