title: Treating skin diseases according to the low dose medicine principles. Data and hypotheses.
abstract: Cytokines, hormones and growth factors, also defined with the collective name of signaling molecules are key regulating agents of physiological (and also pathological) functions according to the principles of Psycho-Neuro-Endocrine-Immunology (P.N.E.I.). From the latest evidences in the fields of Molecular Biology, P.N.E.I. and nano-concentration, a new medical approach surfaces: the Low Dose Medicine (LDM), a new tool for the study and the design of therapeutic strategies based on immune rebalance interventions. LDM suggest the use of low-doses of activated signaling molecules in order to restore P.N.E.I. homeostatic conditions and an increasing number of scientific evidences of LDM approach efficacy and safety support LDM-based therapeutic approach for the treatment of many dermatological diseases such as Psoriasis Vulgaris, Vitiligo and Atopic Dermatitis.
authors.affiliation: Professor and Chair of Dermatology, University of Rome G.Marconi, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.affiliation: Dept. Dermatology, 2nd Medical School, Charles University, Prague.
authors.forename: J
authors.initials: J
authors.lastname: Hercogova
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wollina
authors.affiliation: Onkoderma-Policlinic for Dermatology, Venereology and Dermatologic surgery, Sofia, Bulgaria.
authors.forename: A A
authors.initials: AA
authors.lastname: Chokoeva
authors.affiliation: University of Rome G. Marconi, Rome, Italy.
authors.forename: Z
authors.initials: Z
authors.lastname: Zarrab
authors.affiliation: Department of dermatologic Sciences, University of Florence, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gianfaldoni
authors.affiliation: Chandigarh University, Punjab, India.
authors.forename: M G
authors.initials: MG
authors.lastname: Roccia
authors.affiliation: Associate Professor of Physiology, University B.I.S. Group of Institutions, Punjab Technical University, Punjab, India.
authors.forename: M
authors.initials: M
authors.lastname: Fioranelli
authors.affiliation: Onkoderma-Policlinic for Dermatology, Venereology and Dermatologic surgery, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev