title: Estimation of risk for diabetes according to the metabolically healthy status stratified by degree of obesity in Korean men.
abstract: Although obesity is clearly identified as a risk factor for diabetes, the relationship between diabetes and metabolically healthy status of obesity is less clear. This study was aimed to evaluate the incidental risk of diabetes according to metabolically healthy status of obesity. 31,834 Korean men without diabetes categorized into six groups according to their metabolically healthy status stratified by degree of obesity were followed up for 5 years: metabolically healthy normal weight (MH-NW), metabolically healthy overweight (MH-OW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MU-NW), metabolically unhealthy overweight (MU-OW), and metabolically unhealthy obese (MUO). Cox proportional hazards analysis was used to measure the risk for diabetes according to their categories. While overall incidence was 9.0 %, incidence of diabetes was in proportion to the degree of obesity and metabolically healthy status (MH-NW: 6.3 %, MH-OW: 7.5 %, MHO: 9.2 %, MU-NW: 11.8 %, MU-OW: 14.9 %, MUO: 20.1 %). When MH-NW was set as reference, the adjusted HRs (95 % CI) for diabetes of the MH-OW, MHO, MU-NW, MU-OW, MUO compared to MH-NW were 1.18 (1.06-1.32), 1.58 (1.03-2.41), 1.81 (1.61-2.04), 2.36 (2.11-2.63), and 3.47 (2.84-4.24), respectively. In conclusion, risk for diabetes was in proportion to the degree of obesity in both metabolically healthy and unhealthy group. Metabolically healthy status was more significant determinant for incident diabetes than obesity itself.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. kkkmin7@hotmail.com.|Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 78 Saemunan-gil, Jongro-Gu, Seoul, 110-746, Republic of Korea. kkkmin7@hotmail.com.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Health Promotion Center, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sungmin
authors.initials: S
authors.lastname: Ye
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Joong-Myung
authors.initials: JM
authors.lastname: Choi
authors.affiliation: Korea Central Cancer Registry, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Oh
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 78 Saemunan-gil, Jongro-Gu, Seoul, 110-746, Republic of Korea.
authors.forename: Sun Yong
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Korea Institute of Drug Safety and Risk Management, Seoul, Republic of Korea.
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Shin
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jai Hyung
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Hong
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Taeg Su
authors.initials: TS
authors.lastname: Ko
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D010641:Phenotype; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment
keywords: Diabetes; Metabolic health; Obesity