title: About the Therapy of Laryngotracheitis (Croup): Significance of Rectal Dosage Forms.
abstract: Glucocorticoids are drugs of choice for treatment of laryngotracheitis (croup). They may be administered orally as tablets or juice, locally as inhalation or rectally as suppository or capsule. If doctors decide to use a rectal administration for practical reasons, it is obvious from a pharmacokinetic and pharmacodynamic point of view that prednisolone capsules have an earlier and stronger anti-inflammatory effect than a prednisone suppository.
authors.affiliation: Institute of Experimental and Clinical Pharmacology, Medical University Graz, Graz, Austria.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Beubler
authors.forename: Peter
authors.initials: P
authors.lastname: Dittrich
mesh_terms: D000285:Administration, Rectal; D003440:Croup / Q000188:drug therapy* / Q000378:metabolism; D004304:Dosage Forms; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D004304:Dosage Forms; D005938:Glucocorticoids; D011239:Prednisolone; D011241:Prednisone