title: A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy.
abstract: White TiO2 nanoparticles (NPs) have been widely used for cancer photodynamic therapy based on their ultraviolet light-triggered properties. To date, biomedical applications using white TiO2 NPs have been limited, since ultraviolet light is a well-known mutagen and shallow penetration. This work is the first report about hydrogenated black TiO2 (H-TiO2 ) NPs with near infrared absorption explored as photothermal agent for cancer photothermal therapy to circumvent the obstacle of ultraviolet light excitation. Here, it is shown that photothermal effect of H-TiO2 NPs can be attributed to their dramatically enhanced nonradiative recombination. After polyethylene glycol (PEG) coating, H-TiO2 -PEG NPs exhibit high photothermal conversion efficiency of 40.8%, and stable size distribution in serum solution. The toxicity and cancer therapy effect of H-TiO2 -PEG NPs are relative systemically evaluated in vitro and in vivo. The findings herein demonstrate that infrared-irradiated H-TiO2 -PEG NPs exhibit low toxicity, high efficiency as a photothermal agent for cancer therapy, and are promising for further biomedical applications.
authors.affiliation: Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Ren
authors.affiliation: Chair Materials for Electrical Engineering and Electronics, Institute of Materials Engineering and Institute of Micro- and Nanotechnologies MarcoNano, TU Ilmenau, Gustav-Kirchhoff-Str. 5, Ilmenau, 98693, Germany.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China.
authors.forename: Leyong
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China.
authors.forename: Zhenzhi
authors.initials: Z
authors.lastname: Shi
authors.affiliation: Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China.
authors.forename: An
authors.initials: A
authors.lastname: Gong
authors.affiliation: Chair Materials for Electrical Engineering and Electronics, Institute of Materials Engineering and Institute of Micro- and Nanotechnologies MarcoNano, TU Ilmenau, Gustav-Kirchhoff-Str. 5, Ilmenau, 98693, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Schaaf
authors.affiliation: Chair Materials for Electrical Engineering and Electronics, Institute of Materials Engineering and Institute of Micro- and Nanotechnologies MarcoNano, TU Ilmenau, Gustav-Kirchhoff-Str. 5, Ilmenau, 98693, Germany.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Public Health Department, Ningbo University, 818 Fenghua Road, Ningbo, 315211, China.
authors.forename: Jinshun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Public Health Department, Ningbo University, 818 Fenghua Road, Ningbo, 315211, China.
authors.forename: Baobo
authors.initials: B
authors.lastname: Zou
authors.affiliation: Affiliated Hospital of Medical School, Ningbo University, 247 People Road, Ningbo, 315020, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Yu
authors.affiliation: College of Environmental & Energy Engineering, Beijing University of Technology, 100 Pingleyuan, Beijing, 100124, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Biological Sciences, University of Wisconsin-Whitewater, 800 W. Main St., Whitewater, WI, 53190, USA.
authors.forename: Eric Michael Bratsolias
authors.initials: EM
authors.lastname: Brown
authors.affiliation: Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 ZhongGuan West Road, Ningbo, 315201, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Wu
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000528:radiation effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D007259:Infrared Rays; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D014018:Tissue Distribution / Q000187:drug effects / Q000528:radiation effects; D014025:Titanium / Q000737:chemistry*; D014183:Transplantation, Heterologous
chemical_list: C009495:titanium dioxide; D011092:Polyethylene Glycols; D006859:Hydrogen; D014025:Titanium
keywords: cancer; hydrogenated black TiO2; photothermal therapy