title: Size Effect of Graphene Oxide on Modulating Amyloid Peptide Assembly.
abstract: Protein misfolding and abnormal assembly could lead to aggregates such as oligomer, proto-fibril, mature fibril, and senior amyloid plaques, which are associated with the pathogenesis of many amyloid diseases. These irreversible amyloid aggregates typically form in vivo and researchers have been endeavoring to find new modulators to invert the aggregation propensity in vitro, which could increase understanding in the mechanism of the aggregation of amyloid protein and pave the way to potential clinical treatment. Graphene oxide (GO) was shown to be a good modulator, which could strongly control the amyloidosis of Aβ (33-42). In particular, quartz crystal microbalance (QCM), circular dichroism (CD) spectroscopy, and atomic force microscopy (AFM) measurements revealed the size-dependent manner of GO on modulating the assembly of amyloid peptides, which could be a possible way to regulate the self-assembled nanostructure of amyloid peptide in a predictable manner.
authors.affiliation: Institute for Advanced Materials, Jiangsu University (P. R. China).
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute for Advanced Materials, Jiangsu University (P. R. China).
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C (Denmark).
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute for Advanced Materials, Jiangsu University (P. R. China). liul@ujs.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C (Denmark). dong@inano.au.dk.
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002942:Circular Dichroism; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D010087:Oxides / Q000737:chemistry*; D058225:Plaque, Amyloid / Q000737:chemistry*; D058525:Quartz Crystal Microbalance Techniques; D013329:Structure-Activity Relationship
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D010087:Oxides; D006108:Graphite
keywords: amyloid peptide; graphene oxide; modulating assembly; size effect; structure activity