title: Quality of Life of Children with Congenital Heart Diseases: A Multicenter Controlled Cross-Sectional Study.
abstract: To assess the health-related quality of life (QoL) in children with congenital heart diseases (CHD) with a validated questionnaire in comparison with control children. We prospectively recruited 282 children with CHD aged from 8 to 18 years in two tertiary care centers (France and Belgium) and 180 same-age controls in randomly selected French schools. Children's QoL was self-reported with the KIDSCREEN-52 questionnaire and reported by parents with the KIDSCREEN-27. QoL scores of each dimension were compared between CHD and controls and between the classes of disease severity. Both centers were comparable for most demographic and clinical data. Age- and gender-adjusted self-reported QoL scores were lower in CHD children than in controls for physical well-being (mean ± SEM 45.97 ± 0.57 vs 50.16 ± 0.71, p < 0.0001), financial resources (45.72 ± 0.70 vs 48.85 ± 0.87, p = 0.01), peers/social support (48.01 ± 0.72 vs 51.02 ± 0.88, p = 0.01), and autonomy in the multivariate analysis (47.63 ± 0.69 vs 49.28 ± 0.85, p = 0.04). Parents-reported scores were lower in CHD children for physical (p < 0.0001), psychological well-being (p = 0.04), peers/social support (p < 0.0001), and school environment (p < 0.0001) dimensions. Similarly, the disease severity had an impact on physical well-being (p < 0.001), financial resources (p = 0.05), and peers/social support (p = 0.01) for self-reported dimensions, and on physical well-being (p < 0.001), psychological well-being (p < 0.01), peers/social support (p < 0.001), and school environment (p < 0.001) for parents-reported dimensions. However, in multivariate analysis on self-reported QoL, disease severity was significantly associated with the self-perception dimension only. Self-reported QoL of CHD children was similar to that of same-age healthy children in seven of 10 dimensions, but parents-reported QoL was impaired in four of five dimensions.
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France. p-amedro@chu-montpellier.fr.|Department of Public Health, EA 3279 Research Unit, Aix-Marseille University, Marseille, France. p-amedro@chu-montpellier.fr.|Physiology and Experimental Biology of Heart and Muscles Laboratory - PHYMEDEXP, UMR CNRS 9214 - INSERM U1046, Montpellier University, Montpellier, France. p-amedro@chu-montpellier.fr.
authors.forename: P
authors.initials: P
authors.lastname: Amedro
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.
authors.forename: R
authors.initials: R
authors.lastname: Dorka
authors.affiliation: Pediatric and Congenital Cardiology Department, St-Luc University Hospital, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Moniotte
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.
authors.forename: S
authors.initials: S
authors.lastname: Guillaumont
authors.affiliation: Pediatric and Congenital Cardiology Department, La Timone University Hospital, Marseille, France.
authors.forename: A
authors.initials: A
authors.lastname: Fraisse
authors.affiliation: Pediatric and Congenital Cardiology Department, La Timone University Hospital, Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Kreitmann
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.
authors.forename: B
authors.initials: B
authors.lastname: Borm
authors.affiliation: Clinical Research and Epidemiology Unit, University Hospital, Montpellier, France.|Clinical Investigation Center, University Hospital, Montpellier, France.
authors.forename: H
authors.initials: H
authors.lastname: Bertet
authors.affiliation: Pediatric and Congenital Cardiology Department, St-Luc University Hospital, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Barrea
authors.affiliation: Pediatric and Congenital Cardiology Department, St-Luc University Hospital, Brussels, Belgium.|Pediatric and Congenital Cardiology Department, La Timone University Hospital, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Ovaert
authors.affiliation: Pediatric and Congenital Cardiology Department, St-Luc University Hospital, Brussels, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Sluysmans
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: De La Villeon
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.|Physiology and Experimental Biology of Heart and Muscles Laboratory - PHYMEDEXP, UMR CNRS 9214 - INSERM U1046, Montpellier University, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Vincenti
authors.affiliation: Pediatric and Congenital Cardiology Department, University Hospital, Montpellier, France.
authors.forename: M
authors.initials: M
authors.lastname: Voisin
authors.affiliation: Department of Public Health, EA 3279 Research Unit, Aix-Marseille University, Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Auquier
authors.affiliation: Clinical Research and Epidemiology Unit, University Hospital, Montpellier, France.|Clinical Investigation Center, INSERM-CIC 1411, Montpellier, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Picot
mesh_terms: D000293:Adolescent; D001530:Belgium; D016022:Case-Control Studies; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005602:France; D006330:Heart Defects, Congenital / Q000523:psychology*; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D010290:Parents / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012574:Schools; D012649:Self Concept; D057566:Self Report; D012720:Severity of Illness Index; D012944:Social Support; D062606:Tertiary Care Centers
keywords: Children; Congenital heart disease; Kidscreen; Pediatric cardiology; Quality of life