title: Infections After Liver Transplantation: A Retrospective, Single-center Study.
abstract: OBJECTIVE
  To access the incidence of infectious problems after liver transplantation (LT).
  
  
  METHODS
  A retrospective, single-center study.
  
  
  METHODS
  Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient's variables, graft variables, surgical data, post-LT clinical data.
  
  
  RESULTS
  Of the 492 patients who underwent LT and the 463 considered for this study, 190 (Group 1, 41%) developed at least 1 infection, with 298 infections detected. Of these, 189 microorganisms were isolated, 81 (51%) gram-positive bacteria (most frequently Staphylococcus spp). Biliary infections were more frequent (mean time of 160.4 ± 167.7 days after LT); from 3 months after LT, gram-negative bacteria were observed (57%). Patients with infections after LT presented lower aminotransferase levels, but higher requirements in blood transfusions, intraoperative vasopressors, hemodialysis, and hospital stay. Operative and cold ischemia times were similar.
  
  
  CONCLUSIONS
  We found a 41% incidence of all infections in a 2-year follow-up after LT. Gram-positive bacteria were more frequent isolated; however, negative bacteria were commonly isolated later. Clinical data after LT were more relevant for the development of infections. Donors' variables should be considered in future analyses.
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Antunes
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Teixeira
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Fortuna
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Moya
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Martins
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Bagulho
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisboa, Portugal.
authors.forename: J P
authors.initials: JP
authors.lastname: Pereira
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Bento
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisboa, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Perdigoto
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisboa, Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Barroso
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisboa, Portugal. Electronic address: par.marcelino@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Marcelino
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D014019:Tissue Donors