title: Fungal biotransformation of ezetimibe.
abstract: Structural transformation of ezetimibe was performed by fungiBeauvaria bassianaandCunninghamella blakesleeana. The metabolites were identified by different spectroscopic techniques as (3R,4S)-1-(4-fluorophenyl)-3-((E)-3-(4-fluorophenyl) allyl)-4-(4-hydroxyphenyl) azetidin-2-one (2), (3R, 4S)-1-(4-fluorophenyl)-3-(3-(4fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl) azetidin-2-one (3), (3R,4S) 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl) propyl)-4-(4-hydroxyphenyl) azetidin-2-one (4) and (2R,5S)-N, 5-bis (4-fluorophenyl)-5-hydroxy-2-(4-hydroxybenzyl) pentanamide (5). This study displays two important features of these fungi, viz., their ability to metabolize halogenated compounds, and their capacity to metabolize drugs that are targets of the UDP-Glucuronyl Transferase System, a phenomenon not commonly observed.
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan ; Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur , Bahawalpur Pakistan.
authors.forename: Irfan
authors.initials: I
authors.lastname: Pervaiz
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur , Bahawalpur Pakistan.
authors.forename: Saeed
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur , Bahawalpur Pakistan.
authors.forename: Farhan Hameed
authors.initials: FH
authors.lastname: Khaliq
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan.
authors.forename: Adeel
authors.initials: A
authors.lastname: Arshad
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.affiliation: Department of Pharmacy, Gomal University , Dera Ismail Khan , Pakistan.
authors.forename: Barkat Ali
authors.initials: BA
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan.
authors.forename: Aftab
authors.initials: A
authors.lastname: Ullah
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan.
authors.forename: Usman
authors.initials: U
authors.lastname: Ali
authors.affiliation: Faculty of Pharmacy, University of Balochistan , Quetta , Pakistan.
authors.forename: Kashif
authors.initials: K
authors.lastname: Iqbal
authors.affiliation: Department of Pharmacy, Abasyn University , Peshawar , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Usman
authors.affiliation: Department of Chemistry, Gomal University , Dera Ismail Khan , Pakistan.
authors.forename: Hafsa
authors.initials: H
authors.lastname: Bibi
authors.affiliation: Islam College of Pharmacy , Sialkot , Pakistan.
authors.forename: Najm Ul Hassan
authors.initials: NU
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, COMSATS Institute of Information Technology , Abbottabad Pakistan.
authors.forename: Wajahat
authors.initials: W
authors.lastname: Mahmood
keywords: Beauvaria bassiana; Cunninghamella blakesleeana; UDP-Glucuronyl transferase system; antihypercholesterolemic; biotransformation; ezetimibe