title: New flavonoids with cytotoxicity from the roots of Flemingia latifolia.
abstract: Flemingia latifolia is a folk medicine in China, which is used for treating rheumatism, arthropathy, chronic nephritis and menopausal syndrome. The phytochemicals of the plant have seldom been studied so far. In present study, three new compounds, a flavanone quinone (flemingiquinone A) (1), a prenylated dihydroflavonoid (khonklonginol I) (2) and an isoflavonoid (flemilatifolin B) (3) were isolated from the roots of F. latifolia. Their structures were established by (1)H and (13)C NMR spectra and 2D NMR experiments, including COSY, HMQC, HMBC and ROESY. Meanwhile, the compounds were evaluated for cytotoxicity against two human cancer cell lines, SMMC-7721 and A-549. The results showed that compounds 1 and 2 possessed moderate antiproliferative effects on SMMC-7721 and A-549 cell lines.
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Guoyong
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Lin
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Guokai
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: minjianqin@163.com.
authors.forename: Minjian
authors.initials: M
authors.lastname: Qin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002681:China; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids
keywords: 2″ 3″-Dihydroxylupinifolin (PubChem CID: 11048450); Acetone (PubChem CID: 180); Chloroform (PubChem CID: 6212); Dimethyl sulfoxide (DMSO) (PubChem CID: 679); Ethanol (PubChem CID: 702); Ethyl ethanoate (EtOAc) (PubChem CID: 8857); Flemilatifolin B; Flemingia latifolia Benth; Flemingiquinone A; Formazan (PubChem CID: 9567750); Khonklonginol I; Methanol (PubChem CID: 887); Methylthiazoletetrazolium (MTT) (PubChem CID: 64965); Paclitaxel (PubChem CID: 36314); Tetramethylsilane (TMS) (PubChem CID: 6396)