title: Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells.
abstract: The abnormality of immune regulation plays a critical role in the pathogenesis of cancer; the underlying mechanism has not been fully understood yet. This study aims to investigate the role of cancer specific T helper (Th)2 response in the inhibition of colon cancer (Cca) cell growth. The results showed that with Cca cell (CT26 cell) extracts as an antigen, the Cca-extract specific Th2 response was induced in the Cca-bearing mice. The Cca mass size was significantly reduced, or radically disappeared (5 out of 10; or 50%); the survival rate was markedly improved in mice immunized with Cca-extract, but not in those immunized with another tumor cell (U87 cell) extracts or to bovine serum albumin. The immunization with Cca-extract also induced Cca cell apoptosis and converted the intra-Cca Tregs to T helper (Th) 9 cells. In conclusion, Cca-specific Th2 responses inhibit Cca growth in a mouse model via inducing Cca cell apoptosis and converting intra-Cca Tregs to Th9 cells.
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Jiang-Qi
authors.initials: JQ
authors.lastname: Liu
authors.affiliation: Department of Surgery, the First Hospital, Liaoning Medical University, Jinzhou, 100044, China.
authors.forename: Xing-Yong
authors.initials: XY
authors.lastname: Li
authors.affiliation: ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China.
authors.forename: Hai-Qiong
authors.initials: HQ
authors.lastname: Yu
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Gui
authors.initials: G
authors.lastname: Yang
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Xiao-Rui
authors.initials: XR
authors.lastname: Geng
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.affiliation: ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mo
authors.affiliation: ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Zeng
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Miao
authors.initials: M
authors.lastname: Zhao
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Longgang Central Hospital, Shenzhen, 518116, China [3] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Fu
authors.affiliation: Department of Surgery, the First Hospital, Liaoning Medical University, Jinzhou, 100044, China.
authors.forename: Hong-Zhi
authors.initials: HZ
authors.lastname: Sun
authors.affiliation: ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Liu
authors.affiliation: 1] ENT Institute of Shenzhen University School of Medicine and Shenzhen Key Laboratory of Allergy &Immunology, 518060, China [2] Brain Body Institute, McMaster University, Hamilton, ON, Canada L8N 4A6.
authors.forename: Ping-Chang
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D037182:T-Cell Antigen Receptor Specificity / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism