title: Apoptosis induced by weisiensin B isolated from Rabdosia weisiensis C.Y. Wu in K562.
abstract: The ent-kaurane diterpenoid weisinensis B shows significant cytotoxicity to human chronic myeloid leukemia K562 cells. It inhibits cell growth at low concentration and kills cells at high concentration. The compound induced cell apoptosis and necrosis mainly associated with G2/M phase cell cycle arrest and the ROS generation is the early event in weisiensin B induced cell apoptosis.
authors.forename: Guo-An
authors.initials: GA
authors.lastname: Liu
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Chang
authors.forename: Xiao-Lu
authors.initials: XL
authors.lastname: Feng
authors.forename: Lan
authors.initials: L
authors.lastname: Ding
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D009336:Necrosis; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D017382:Reactive Oxygen Species; C539120:weisiensin B