title: Influence on intraocular pressure of anti-inflammatory treatments after selective laser trabeculoplasty.
abstract: BACKGROUND
  Selective laser trabeculoplasty (SLT) is an effective and safe procedure to lower intraocular pressure (IOP) in the management of open-angle glaucoma. The post-laser inflammatory reaction could be positively implicated in SLT efficacy and the relevance of postoperative use of topical anti-inflammatory remains controversial. The goal of this study is to determine the effect of various anti-inflammatory treatments on intraocular pressure and on side effects following SLT.
  
  
  METHODS
  A prospective, randomized, double-blind study with a control group was conducted. Ninety-six eyes of 67 patients with primary open-angle glaucoma who underwent SLT were enrolled in this study between March 2009 and March 2012. Eyes recruited in the study were randomized to receive either prednisolone acetate 1%, diclofenac 0.1% or a placebo. The 3 treatments were administered 4 times a day for 5 days following SLT. The intraocular pressures were measured at regular intervals during the 6-months follow-up period. Side effects were also evaluated with a questionnaire as well as with the ocular exam.
  
  
  RESULTS
  The analysis of the relative IOP decrease over the 6-months period revealed a significant difference between the time points of follow-up (P<0.0001), but no group effect (P=0.2980). No significant difference regarding anterior chamber inflammation and discomfort was observed between the 3 groups.
  
  
  CONCLUSIONS
  There was no difference in intraocular pressure reduction, intraocular inflammation or ocular discomfort post-SLT when comparing the 3 treatment modalities.
authors.affiliation: Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Champagne
authors.affiliation: Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada.
authors.forename: J-L
authors.initials: JL
authors.lastname: Anctil
authors.affiliation: Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Goyette
authors.affiliation: Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Lajoie
authors.affiliation: Département d'ophtalmologie et d'ORL-CCF, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, G1V 0A6 Québec, QC, Canada; Centre universitaire d'ophtalmologie et Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec, 1050, chemin Sainte-Foy, G1S 4L8 Québec, QC, Canada. Electronic address: beatrice.desmarchais@fmed.ulaval.ca.
authors.forename: B
authors.initials: B
authors.lastname: Des Marchais
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D003000:Clonidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004008:Diclofenac / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004311:Double-Blind Method; D058447:Eye Pain / Q000188:drug therapy / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D018448:Models, Immunological; D010149:Postoperative Pain / Q000188:drug therapy / Q000517:prevention & control; D010919:Placebos; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control*; D011239:Prednisolone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014130:Trabeculectomy; D016896:Treatment Outcome; D014606:Uveitis, Anterior / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D004008:Diclofenac; C016986:apraclonidine; C009935:prednisolone acetate; D011239:Prednisolone; D003000:Clonidine
keywords: Anti-inflammatoire; Anti-inflammatoire non stéroïdien; Anti-inflammatory; Glaucome à angle ouvert; Intraocular pressure; Nonsteroidal anti-inflammatory; Open-angle glaucoma; Pression intraoculaire; Steroid; Stéroïde; Trabeculoplasty; Trabéculoplastie