title: Numerical Study of Pillar Shapes in Deterministic Lateral Displacement Microfluidic Arrays for Spherical Particle Separation.
abstract: Deterministic lateral displacement (DLD) arrays containing shaped pillars have been found to be more effective in biomedical sample separation. This study aims to numerically investigate the interplay between particles and microfluidic arrays, and to find out the key factors in determining the critical size of a DLD device with shaped pillars. A new formula is thus proposed to estimate the critical size for spherical particle separation in this kind of new DLD microfluidic arrays. The simulation results show that both rectangular and I-shaped arrays have considerably smaller critical sizes. The ratio of sub-channel widths is also found to play an important role in reducing the critical sizes. This paves a valuable way toward designing high-performance DLD microfluidic arrays.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Wei
authors.forename: Hui
authors.initials: H
authors.lastname: Song
authors.forename: Zaiyi
authors.initials: Z
authors.lastname: Shen
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.forename: Xianzhi
authors.initials: X
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bing Nan
authors.initials: BN
authors.lastname: Li
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010316:Particle Size