title: Two new triterpenoid saponins from the aerial parts of Anemone taipaiensis.
abstract: Phytochemical study on the aerial parts of Anemone taipaiensis for the first time led to the isolation of two new oleanane-type triterpenoid saponins 1 and 2, together with four known saponins (3-6). Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Saponins 2-4 exhibited cytotoxicity against human glioblastoma U251MG cell line with IC50 values ranging from 1.56 to 80.62 μM.
authors.affiliation: a Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University , Xi'an 710032 , China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Xia-Yin
authors.initials: XY
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Hua
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
mesh_terms: D031883:Anemone / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000601790:3-O-alpha-L-arabinopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-2)-(alpha-L-rhamnopyranosyl-(1-4))-beta-D-glucopyranosyl gypsogenin 28-O-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester; C000601789:3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl-(1-4)-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D009828:Oleanolic Acid
keywords: Anemone taipaiensis; Ranunculaceae; aerial part; cytotoxicity; triterpenoid saponin