title: Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.
abstract: Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases.
authors.affiliation: Rheumatology Department at Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. Electronic address: ckonya@bidmc.harvard.edu.
authors.forename: Christine
authors.initials: C
authors.lastname: Konya
authors.affiliation: Rheumatology Department at Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. Electronic address: zpaz@bidmc.harvard.edu.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Paz
authors.affiliation: Rheumatology Department at Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. Electronic address: sapostol@bidmc.harvard.edu.
authors.forename: Sokratis A
authors.initials: SA
authors.lastname: Apostolidis
authors.affiliation: Rheumatology Department at Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, United States. Electronic address: gtsokos@bidmc.harvard.edu.
authors.forename: George C
authors.initials: GC
authors.lastname: Tsokos
mesh_terms: D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000188:drug therapy / Q000276:immunology
chemical_list: D020381:Interleukin-17
keywords: Autoimmune diseases; Biological agents; Interleukin-17