title: Impact of anesthesia on cancer recurrence.
abstract: Surgery remains the mainstay treatment in the majority of solid cancers. Anesthetics and analgesics used during the perioperative period may modulate the innate and adaptive immune system, inflammation and angiogenesis, and have a direct effect on cancer cells that could ultimately modify oncological outcomes. For instance, volatile anesthetics and opioid analgesics have shown predominantly pro-tumor effects, while propofol, non-steroid anti-inflammatory drugs have mostly anticancer effects. Researchers have been especially interested in investigating the association between the use of regional anesthesia techniques and the postoperative survival of patients with cancers. Since the results of the current retrospective studies are conflicting, several researchers are conducting prospective randomized trials.
authors.affiliation: Department of Anaesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Cancer, Houston, TX, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Lee
authors.affiliation: Department of Anaesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Cancer, Houston, TX, USA; Anesthesia and Surgical Oncological Research Group, TX, USA. Electronic address: jcata@mdanderson.org.
authors.forename: J P
authors.initials: JP
authors.lastname: Cata
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D000758:Anesthesia / Q000009:adverse effects* / Q000379:methods; D000765:Anesthesia, Conduction / Q000009:adverse effects / Q000379:methods; D000777:Anesthetics / Q000009:adverse effects* / Q000145:classification; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007249:Inflammation; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D018365:Neoplasm, Residual; D009369:Neoplasms / Q000601:surgery; D009389:Neovascularization, Pathologic / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors
keywords: Anestesia; Anesthesia; Angiogenesis; Inflammación; Inflammation; Neoplasia; Neoplasms; Recurrence; Recurrencia