title: A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7.
authors.affiliation: Department of Biology, University of Bari, Bari, Italy.
authors.forename: Gemma
authors.initials: G
authors.lastname: Macchia
authors.affiliation: Department of Biology, University of Bari, Bari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Lonoce
authors.affiliation: Department of Biology, University of Bari, Bari, Italy.
authors.forename: Santina
authors.initials: S
authors.lastname: Venuto
authors.affiliation: UO Anatomia Patologica, Ospedale S. Martino, Belluno, Italy.
authors.forename: Ettore
authors.initials: E
authors.lastname: Macrí
authors.affiliation: Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Palumbo
authors.affiliation: Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Carella
authors.affiliation: UO Anatomia Patologica, Ospedale S. Martino, Belluno, Italy.
authors.forename: Crocifissa
authors.initials: C
authors.lastname: Lo Cunsolo
authors.affiliation: UO Anatomia Patologica, Ospedale S. Martino, Belluno, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Iuzzolino
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, IBSAL, IBMCC, Centro de Investigación del Cáncer, Universidad de Salamanca, CSIC, Salamanca, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Hernández-Sánchez
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, IBSAL, IBMCC, Centro de Investigación del Cáncer, Universidad de Salamanca, CSIC, Salamanca, Spain.
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Hernandez-Rivas
authors.affiliation: Department of Biology, University of Bari, Bari, Italy. cleliatiziana.storlazzi@uniba.it.
authors.forename: Clelia T
authors.initials: CT
authors.lastname: Storlazzi
mesh_terms: D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D008875:Middle Aged; D009363:Neoplasm Proteins; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D062085:RNA, Long Noncoding / Q000235:genetics; D014178:Translocation, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: C482307:DLEU7 protein, human; C505361:MIRN15 microRNA, human; C505362:MIRN16 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; C521123:PVT1 long-non-coding RNA, human; D016271:Proto-Oncogene Proteins c-myc; D062085:RNA, Long Noncoding; D025521:Tumor Suppressor Proteins
keywords: B-cell chronic lymphocytic leukaemia; MIR15A/MIR16-1; MYC; del(13q); translocation