title: Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity.
abstract: The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(-52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases.
authors.affiliation: N. I. Pirogov Russian National Research Medical University, Moscow, Russia, lvgan@yandex.ru.
authors.forename: L V
authors.initials: LV
authors.lastname: Gankovskaya
authors.forename: O A
authors.initials: OA
authors.lastname: Svitich
authors.forename: O V
authors.initials: OV
authors.lastname: Artem'eva
authors.forename: A M
authors.initials: AM
authors.lastname: Miroshnichenkova
authors.forename: K V
authors.initials: KV
authors.lastname: Rusanova
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000375:Aging; D000483:Alleles; D004247:DNA / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008136:Longevity / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D055815:Young Adult; D023083:beta-Defensins / Q000235:genetics*
chemical_list: C406407:DEFB1 protein, human; C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D023083:beta-Defensins; D004247:DNA