title: Feasibility of using 'lung density' values estimated from EIT images for clinical diagnosis of lung abnormalities in mechanically ventilated ICU patients.
abstract: This paper reports on the results of a study which compares lung density values obtained from electrical impedance tomography (EIT), clinical diagnosis and CT values (HU) within a region of interest in the lung. The purpose was to assess the clinical use of lung density estimation using EIT data. In 11 patients supported by a mechanical ventilator, the consistency of regional lung density measurements as estimated by EIT was validated to assess the feasibility of its use in intensive care medicine. There were significant differences in regional lung densities recorded in the supine position between normal lungs and diseased lungs associated with pneumonia, atelectasis and pleural effusion (normal; 240 ± 71.7 kg m(-3), pneumonia; 306 ± 38.6 kg m(-3), atelectasis; 497 ± 130 kg m(-3), pleural effusion; 467 ± 113 kg m(-3): Steel-Dwass test, p < 0.05). In addition, in order to compare lung density with CT image pixels, the image resolution of CT images, which was originally 512 × 512 pixels, was changed to 16 × 16 pixels to match that of the EIT images. The results of CT and EIT images from five patients in an intensive care unit showed a correlation coefficient of 0.66 ± 0.13 between the CT values (HU) and the lung density values (kg m(-3)) obtained from EIT. These results indicate that it may be possible to obtain a quantitative value for regional lung density using EIT.
authors.affiliation: Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Nebuya
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Koike
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imai
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Iwashita
authors.forename: Brian H
authors.initials: BH
authors.lastname: Brown
authors.forename: Kazui
authors.initials: K
authors.lastname: Soma
mesh_terms: D017097:Electric Impedance; D005240:Feasibility Studies; D006801:Humans; D007362:Intensive Care Units; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D014054:Tomography; D014057:Tomography, X-Ray Computed