title: (Hyper)tension release by N-terminal acetylation.
abstract: A recent study links N-terminal acetylation and N-end rule degradation to blood pressure regulation. N-terminal mutants of Rgs2, a key G-protein regulator, are differentially processed by N-terminal acetyltransferases and the two branches of the N-end rule pathway. This leads to an imbalance in the signaling governing blood pressure.
authors.affiliation: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.
authors.forename: Henriette
authors.initials: H
authors.lastname: Aksnes
authors.affiliation: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway.
authors.forename: Adrian
authors.initials: A
authors.lastname: Drazic
authors.affiliation: Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway; Department of Surgery, Haukeland University Hospital, N-5021 Bergen, Norway. Electronic address: thomas.arnesen@uib.no.
authors.forename: Thomas
authors.initials: T
authors.lastname: Arnesen
mesh_terms: D006801:Humans; D020710:RGS Proteins / Q000378:metabolism*
chemical_list: D020710:RGS Proteins
keywords: G-protein signaling; N-end rule; N-terminal acetylation; Rgs2; blood pressure regulation; protein degradation