title: [Radiation preconditioning of mouse retina results in tolerance to MNU-induced degeneration and stimulates retinal recovery].
abstract: Emerging body of data indicate protecting effect of low level of stress (preconditioning) on retina. Our previous studies have revealed a non-linear dose-response relationship for cytotoxic effect of both ionizing radiation and N-methyl-N-nitrosourea (MNU) on mouse retina. Moreover, non-cytotoxic dose of MNU increased tolerance of retina to following challenge dose of MNU. This result displays protection of retina through mechanism of recovery. In the present study we used the mouse model for MNU-induced retinal degeneration to evaluate the adaptive response of the retina to proton irradiation and implication of glial Muller cells in this response. In this paper, we have shown that the recovery of the retina after exposure to genotoxic agents is associated with an increased efficiency of DNA damage repair and lowered death of retinal photoreceptors.
authors.forename: V A
authors.initials: VA
authors.lastname: Tronov
authors.forename: Yu V
authors.initials: YV
authors.lastname: Vinogradova
authors.forename: V A
authors.initials: VA
authors.lastname: Poplinskaya
authors.forename: E I
authors.initials: EI
authors.lastname: Nekrasova
authors.forename: M A
authors.initials: MA
authors.lastname: Ostrovsky
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D020419:Photoreceptor Cells, Vertebrate / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D011839:Radiation, Ionizing; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D012162:Retinal Degeneration / Q000139:chemically induced / Q000473:pathology; D013312:Stress, Physiological
chemical_list: D008770:Methylnitrosourea