title: Pattern of soluble CD5 and CD6 lymphocyte receptors in critically ill patients with septic syndromes.
abstract: OBJECTIVE
  Soluble forms of CD5 and CD6 lymphocyte surface receptors (sCD5 and sCD6) are molecules that seem to prevent experimental sepsis when exogenously administered. The aim of this study was to assess sCD5 and sCD6 levels in patients with septic syndromes.
  
  
  METHODS
  The study population consisted of 218 patients admitted to the medical intensive care unit (ICU) presenting either septic syndromes or noninfectious systemic inflammatory response syndrome at admission or within the first 48 hours. The sCD5 and sCD6 levels were analyzed by sandwich enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Almost 50% of the patients had undetectable levels of sCD5 or sCD6, with no differences in clinical or biological variables with detectable patients. There was a correlation between the delta Sequential Organ Failure Assessment score and both sCD6 and sCD5 levels in all groups. Patients with sCD5 or sCD6 levels greater than 1500 ng/mL presented a higher in-ICU mortality (P < .05). Logistic regression analysis showed that increased sCD6 levels were associated with an increased risk of in-ICU mortality.
  
  
  CONCLUSIONS
  Levels of sCD5 and sCD6 in critically ill patients with systemic inflammatory response syndrome present a high variation and an elevated proportion of undetectability. Levels of sCD6 are associated with an increased risk of mortality in these patients.
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: jaibar@clinic.ub.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Aibar
authors.affiliation: Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: mariomartnez80@gmail.com.
authors.forename: Mario
authors.initials: M
authors.lastname: Martínez-Florensa
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: pcastro@clinic.ub.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Castro
authors.affiliation: Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: esthercdm@gmail.com.
authors.forename: Esther
authors.initials: E
authors.lastname: Carrasco
authors.affiliation: Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain. Electronic address: crisescodaiferran@gmail.com.
authors.forename: Cristina
authors.initials: C
authors.lastname: Escoda-Ferran
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: sfernanm@clinic.ub.es.
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: mbutjosa@clinic.ub.es.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Butjosa
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: chernan1@clinic.ub.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Hernández
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: marianorinaudo@gmail.com.
authors.forename: Mariano
authors.initials: M
authors.lastname: Rinaudo
authors.affiliation: Group of Immunoreceptors of the Innate and Adaptive System, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain; Department of Immunology, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona Villarroel 170, 08036 Barcelona, Spain. Electronic address: flozano@clinic.ub.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
authors.affiliation: Medical Intensive Care Unit, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain. Electronic address: nicolas@clinic.ub.es.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Nicolás
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D018956:CD5 Antigens / Q000378:metabolism*; D016638:Critical Illness; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D011379:Prognosis; D018805:Sepsis / Q000276:immunology* / Q000401:mortality; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018956:CD5 Antigens; C062279:CD6 antigen
keywords: CD5; CD6; Sepsis; Systemic inflammatory response syndrome