title: Transcriptional regulation of chemokine genes: a link to pancreatic islet inflammation?
abstract: Enhanced expression of chemotactic cytokines (aka chemokines) within pancreatic islets likely contributes to islet inflammation by regulating the recruitment and activation of various leukocyte populations, including macrophages, neutrophils, and T-lymphocytes. Because of the powerful actions of these chemokines, precise transcriptional control is required. In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet β-cells, which include contributions from the NF-κB and STAT1 pathways. We further discuss increased chemokine expression in pancreatic islets during autoimmune-mediated and obesity-related development of diabetes.
authors.affiliation: Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. susan.collier@pbrc.edu.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Burke
authors.affiliation: Laboratory of Islet Biology and Inflammation, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Jason.collier@pbrc.edu.
authors.forename: J Jason
authors.initials: JJ
authors.lastname: Collier
mesh_terms: D000818:Animals; D018925:Chemokines / Q000235:genetics* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000473:pathology; D015533:Transcriptional Activation
chemical_list: D018925:Chemokines
keywords: chemokine; diabetes; inflammation; islet; transcription