title: Cell Interactions with Vascular Regenerative MAA-Based Materials in the Context of Wound Healing.
abstract: In diabetic patients the development of chronic non-healing wounds is a common complication. A methacrylic acid-based biomaterial is a vascular regenerative material that enhances diabetic healing without the use of cells or growth factors. The bioactive nature of this material is thought to be associated with its anionic charge or surface chemistry. Contact between the methacrylic acid-based biomaterial and tissue begins with protein (including complement) adsorption and is followed by interaction of the biomaterial with resident and infiltrating cells in the wound bed (e.g., macrophages and endothelial cells). This results in changes to their surface receptors to activate phosphorylation cascades that lead to differential activation of signalling pathways such as those involving osteopontin and sonic hedgehog. These changes modulate the phenotype of the cells in the wound bed, eventually improving vessel formation and wound healing. Understanding the molecular and cellular mechanisms will have broad implications for biomaterials, not just the methacrylic acid-based material, and will facilitate the advancement of regenerative biomaterials for diverse applications.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Lisovsky
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada.
authors.forename: Michael Dean
authors.initials: MD
authors.lastname: Chamberlain
authors.affiliation: Department of Chemical Engineering, Queen's University, K7L 3N6, Canada.
authors.forename: Laura Anne
authors.initials: LA
authors.lastname: Wells
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, M5S 3G9, Canada.|Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Suite 407, Toronto, Ontario, M5S 3G9, Canada.
authors.forename: Michael Vivian
authors.initials: MV
authors.lastname: Sefton
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D006801:Humans; D008689:Methacrylates / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D044968:Regenerative Medicine; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; C008384:methacrylic acid
keywords: biomaterials; macrophages; methacrylic acid; vascularization; wound healing