title: Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment.
abstract: A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome-based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Liu
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Tu
authors.forename: Fan
authors.initials: F
authors.lastname: Feng
authors.forename: Haifeng
authors.initials: H
authors.lastname: Shi
authors.forename: Keping
authors.initials: K
authors.lastname: Chen
authors.forename: Ximing
authors.initials: X
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D022701:Virosomes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D022701:Virosomes