title: [Progress on interleukin-27 in tumor immunity].
abstract: As a member of IL-6/IL-12 cytokine family, IL-27 is a heterodimeric cytokine composed of the p28 and EBI3. Functioning as a linkage between innate and adaptive immunity, IL-27 is mainly produced by activated antigen-presenting cells and has a variety of responder cells including T cells, NK cells, macrophages and dendritic cells. IL-27 plays an antitumor role through promoting the production of cytotoxic T cells, regulating the differentiation of T cell subsets, enhancing the function of NK cells and inhibiting the angiogenesis. On the other hand, IL-27 may also have a positive effect on tumor progress and metastasis. IL-27 can be used as a reference marker for tumor diagnosis, due to its relation to the occurrence and development of tumors. This article reviews the research progress on the roles of IL-27 in tumor biological regulation.
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Qing-qing
authors.initials: QQ
authors.lastname: Wang
mesh_terms: D003713:Dendritic Cells; D006801:Humans; D064094:Interleukin-27 / Q000276:immunology*; D007694:Killer Cells, Natural; D008264:Macrophages; D009369:Neoplasms / Q000276:immunology*; D016176:T-Lymphocyte Subsets; D013602:T-Lymphocytes, Cytotoxic
chemical_list: D064094:Interleukin-27