title: Chronic Ocular Graft vs Host Disease as a Serious Complication of Allogeneic Hematopoietic Stem Cell Transplantation: Case Report.
abstract: Chronic graft-vs-host disease (cGVHD) is a serious systemic immunological complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Ocular GVHD (O-GVHD) is frequently associated with cGVHD. Secondary corneal epithelial changes can occur in the setting of advanced chronic O-GVHD-associated keratoconjunctivitis sicca (KCS), which generally has a stable course with conventional medical treatment. Bilateral corneal ulcers and ocular perforation, although not frequent, can occur in most extreme cases. The authors describe 2 clinical cases of ocular perforation (Clinical case 1) and bilateral simultaneous corneal ulcers (Clinical case 2) due to advanced chronic O-GVHD, which can rarely occur despite treatment. A close ophthalmological follow-up and good dialogue with the multidisciplinary transplantation team are essential after allo-HSCT.
authors.affiliation: Ophthalmology Department, Hospital Santa Maria (Centro Hospitalar Lisboa Norte), Lisbon, Portugal; Faculty of Medicine of Lisbon, University of Lisbon, Lisbon, Portugal. Electronic address: ivogama20@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Gama
authors.affiliation: Ophthalmology Department, Hospital Santa Maria (Centro Hospitalar Lisboa Norte), Lisbon, Portugal; Faculty of Medicine of Lisbon, University of Lisbon, Lisbon, Portugal.
authors.forename: W
authors.initials: W
authors.lastname: Rodrigues
authors.affiliation: Ophthalmology Department, Hospital Santa Maria (Centro Hospitalar Lisboa Norte), Lisbon, Portugal; Faculty of Medicine of Lisbon, University of Lisbon, Lisbon, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Franco
authors.affiliation: Ophthalmology Department, Hospital Santa Maria (Centro Hospitalar Lisboa Norte), Lisbon, Portugal; Faculty of Medicine of Lisbon, University of Lisbon, Lisbon, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Almeida
authors.affiliation: Ophthalmology Department, Hospital Santa Maria (Centro Hospitalar Lisboa Norte), Lisbon, Portugal; Faculty of Medicine of Lisbon, University of Lisbon, Lisbon, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Monteiro-Grillo
mesh_terms: D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000175:diagnosis; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D008297:Male; D008875:Middle Aged; D055815:Young Adult