title: Stenotrophomonas maltophilia keratitis treated with trimethoprim-sulfamethoxazole.
abstract: METHODS
  An 84 year-old woman with persistent epithelial defect and a dense stromal infiltrate post-corneal transplantation. According to the microbiological results, it was due to a Stenotrophomonas maltophilia (S. maltophilia) resistant to all antibiotics except trimethoprim-sulfamethoxazole (TMP/SMX). Healing was achieved after three weeks of treatment with oral and topical TMP/SMX.
  
  
  CONCLUSIONS
  S. maltophilia is an opportunistic microorganism rarely described in ophthalmology. It is associated with conjunctivitis, keratitis, scleritis, dacryrocystitis, cellulitis, and endophthalmitis with significant morbidity. Treatment is complicated because of its resistances to broad-spectrum antibiotics. TMP/SMX monotherapy can be considered an option of treatment for this type of keratitis.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Madrid, España. Electronic address: diezalvarezl@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Díez-Álvarez
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: B
authors.initials: B
authors.lastname: Lumbreras-Fernández
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Madrid, España; Clínica Rementería, Madrid, España.
authors.forename: J L
authors.initials: JL
authors.lastname: García-Pérez
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D057111:Descemet Stripping Endothelial Keratoplasty; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D009894:Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology*; D020615:Stenotrophomonas maltophilia / Q000302:isolation & purification*; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000382:microbiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Ciprofloxacin; Ciprofloxacino; Cornea; Córnea; Keratitis; Queratitis; Stenotrophomonas maltophilia; Trimethoprim-sulfamethoxazole; Trimetoprima-sulfametoxazol