title: Encapsulated cellular implants for recombinant protein delivery and therapeutic modulation of the immune system.
abstract: Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines.
authors.affiliation: Division of Neurology, Department of clinical Neuroscience, Geneva University Hospitals, 1205 Geneva, Switzerland. aurelien.lathuiliere@hcuge.ch.|Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. aurelien.lathuiliere@hcuge.ch.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Lathuilière
authors.affiliation: Department of Oncology, Geneva University Hospital and Medical School, 1205 Geneva, Switzerland. nicolas.mach@hcuge.ch.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mach
authors.affiliation: Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. bernard.schneider@epfl.ch.
authors.forename: Bernard L
authors.initials: BL
authors.lastname: Schneider
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000544:Alzheimer Disease / Q000276:immunology / Q000628:therapy; D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D019496:Cancer Vaccines / Q000008:administration & dosage; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D016207:Cytokines / Q000008:administration & dosage; D005818:Genetic Engineering / Q000379:methods; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D007107:Immune System; D007116:Immunization, Passive / Q000379:methods; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D019636:Neurodegenerative Diseases / Q000276:immunology / Q000628:therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines; D016207:Cytokines; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: Alzheimer’s disease; adjuvant; cancer vaccine; cellular implants; cytokine; encapsulation; genetic engineering; passive immunization; recombinant antibodies