title: Foot ulcers in klippel-trenaunay syndrome: two case reports and one metatypical Basal cell carcinoma.
abstract: Klippel-Trenaunay syndrome (KTS) is a congenital malformation with vascular anomalies of capillaries, veins and lymphatics and hypertrophy of bones and soft tissues, associated with microdeletion of 2q37.3 and upregulation of angiogenic factor AGGF1. Although KTS predisposes to venous thromboembolic diseases and may be associate with potentially life-threatening vascular complications including bleeding, pulmonary embolism, and deep vein thrombosis, the development of leg or foot ulcers is uncommon. We present two adult patients with KTS and foot ulcers and advise doctors to keep in mind that chronic foot ulcers in KTS may have an underlying neoplasia.
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Langner
authors.affiliation: Centre of Rehabilitative Medicine and Physical Therapy, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Heining
authors.affiliation: Institute of Pathology Georg Schmorl, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Schönlebe
authors.affiliation: Policlinic for Dermatology and Venereology, Saint Kliment Ohridski University, Medical Faculty, University Hospital Lozenetz, Sofia, Bulgaria.
authors.forename: G
authors.initials: G
authors.lastname: Tchernev
authors.affiliation: "Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia, Bulgaria.
authors.forename: A A
authors.initials: AA
authors.lastname: Chokoeva
authors.affiliation: Professor and Chair of Dermatology University of Rome G.Marconi Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Lotti
authors.affiliation: Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wollina