title: MANAGEMENT OF ENDOCRINE DISEASE: Paediatric Cushing's disease.
abstract: Cushing's disease (CD) is the commonest form of ACTH-dependent Cushing's syndrome and is a rare clinical diagnosis in paediatric and adolescent patients. CD is caused by an ACTH-secreting pituitary corticotroph adenoma and is associated with significant morbidity in children; therefore, early diagnosis and treatment are critical for optimal therapeutic outcome. This review highlights the key clinical and biochemical features of paediatric CD and appraises current practices in diagnosis and management. A close liaison with adult endocrinology colleagues, particularly, for interpretation of investigations and definition of therapeutic strategy is strongly advised.
authors.affiliation: Barts and the London School of Medicine and DentistryWilliam Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, 1st Floor, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK h.l.storr@qmul.ac.uk.
authors.forename: Helen L
authors.initials: HL
authors.lastname: Storr
authors.affiliation: Barts and the London School of Medicine and DentistryWilliam Harvey Research Institute, Centre for Endocrinology, Queen Mary University of London, 1st Floor, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Savage
mesh_terms: D000293:Adolescent; D000315:Adrenalectomy; D002648:Child; D002675:Child, Preschool; D006801:Humans; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery / Q000628:therapy*; D010902:Pituitary Gland / Q000601:surgery