title: Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia.
abstract: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.
authors.affiliation: Department of Chemical Engineering, National Taiwan University No 1, Taipei, Taiwan.
authors.forename: Shih-Hsiang
authors.initials: SH
authors.lastname: Liao
authors.affiliation: Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Liu
authors.affiliation: National Institute for Materials Science, Ibaraki, Japan.
authors.forename: Bishnu Prasad
authors.initials: BP
authors.lastname: Bastakoti
authors.affiliation: International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Taoyua, Taiwan.
authors.forename: Yung
authors.initials: Y
authors.lastname: Chang
authors.affiliation: National Institute for Materials Science, Ibaraki, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Institute of Biomedical Engineering, National Taiwan University No 1, Taipei City, Taiwan ; Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan.
authors.forename: Feng-Huei
authors.initials: FH
authors.lastname: Lin
authors.affiliation: Department of Chemical Engineering, National Taiwan University No 1, Taipei, Taiwan ; Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan.
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
mesh_terms: D000464:Alginates / Q000737:chemistry* / Q000493:pharmacokinetics; D001777:Blood Coagulation / Q000187:drug effects; D011232:Chemical Precipitation; D016503:Drug Delivery Systems / Q000379:methods; D005290:Ferric Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D005334:Fever / Q000188:drug therapy*; D005688:Galactosamine / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry / Q000493:pharmacokinetics; D056945:Hep G2 Cells / Q000187:drug effects; D006603:Hexuronic Acids / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D060526:Magnetic Fields; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013818:Thermogravimetry / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D005290:Ferric Compounds; D006603:Hexuronic Acids; C000499:ferric oxide; D005688:Galactosamine; D020723:Glucuronic Acid
keywords: alginate; hyperthermia; iron oxide; pre-gel; targeting