title: Effects of chitin and its derivatives on human cancer cells lines.
abstract: The present study is focused on the effect of chitin derivatives against human cancer cell lines RD and Hep2. As an outcome from this research, chitin was cytotoxic at IC50 = 400 μg/ml and 200 μg/ml against Hep2 cells and RD cells lines, respectively. Irradiated chitin had an IC50 value of 450 μg/ml for Hep2 and an IC50 of 200 μg/ml for RD. The lowest IC50 is attributed to chitosan, 300 μg/ml in Hep2 and 190 μg/ml in RD.
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Bouhenna
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.
authors.forename: R
authors.initials: R
authors.lastname: Salah
authors.affiliation: Université USTHB Bab El Zouar Alger, Bab Ezzouar, Algeria.
authors.forename: R
authors.initials: R
authors.lastname: Bakour
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria. nadjibdrouiche@yahoo.fr.|Centre de Recherche en technologie des Semi-conducteurs pour l'Energétique (CRTSE). 2, Bd Frantz Fanon BP140, Alger - 7 merveilles, 16038, Alger, Algeria. nadjibdrouiche@yahoo.fr.
authors.forename: N
authors.initials: N
authors.lastname: Drouiche
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Abdi
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Grib
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.|Pôle Technologique, Université de BOUIRA, 10000, Bouira, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Lounici
authors.affiliation: Unité de Recherche URIE, Ecole Nationale Polytechnique, 10 Avenue Pasteur El Harrach, Alger, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Mameri
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D002686:Chitin / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008970:Molecular Weight
chemical_list: D000970:Antineoplastic Agents; D002686:Chitin
keywords: Biopolymers; Chitin; Chitosan; Cytotoxicity; Enzymatic hydrolysis