title: Elevated Expression of Pentraxin 3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive Protein.
abstract: A 20-year-old woman was admitted to our hospital with an elevated serum creatinine level of 1.61 mg/dL and a normal C-reactive protein level of less than 0.1 mg/dL. Her myeloperoxidase anti-neutrophil cytoplasmic antibody (ANCA) titer was slightly increased at 9.2 U/mL; a kidney biopsy revealed that 23 of 32 glomeruli had crescents. The expression of pentraxin 3 was detected in her kidney and her plasma pentraxin 3 level was elevated at 63.53 ng/mL. Plasma pentraxin 3 levels may be an activity marker for ANCA-associated glomerulonephritis, particularly when serum C-reactive protein levels are within the normal limits.
authors.affiliation: Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Ishida
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakai
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hara
authors.forename: Naofumi
authors.initials: N
authors.lastname: Imai
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishi
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood* / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007678:Kidney Glomerulus / Q000473:pathology*; D009195:Peroxidase / Q000276:immunology*; D011239:Prednisolone / Q000008:administration & dosage*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D016896:Treatment Outcome; D000099153:Pentraxins
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D002097:C-Reactive Protein; D007166:Immunosuppressive Agents; D009195:Peroxidase; D011239:Prednisolone; D000683:Serum Amyloid P-Component; D000099153:Pentraxins