title: [The cord blood bank at the Instituto Mexicano del Seguro Social].
abstract: BACKGROUND
  Hematopoietic stem cells have been used for over 50 years in the treatment of diverse diseases. Umbilical cord blood (UCB) has proved to be a viable source of hematopoietic stem cells for transplantation purposes. The aim was to report the contribution of the umbilical cord blood bank over the past 9 years, in the treatment of various diseases.
  
  
  METHODS
  Since 2005 the number of units of blood from the umbilical cord and their use for transplantation in diverse disease were analyzed. A selection of volunteer pregnant women in labor was performed. Umbilical cord blood was obtained from them, which underwent processing, cryopreservation and validation, as well as compatibility test before using for transplantation.
  
  
  RESULTS
  Ten thousand and ninety nine candidates to donation were assessed, from whom 2481 unit of UCB were collected. Of these, 893 unit were processed and cryopreserved for transplantation. In 65% of cases there was histocompatibility between the cord cell and the receptors. Transplantation was done in 87 patients, 67% had hematologic neoplasias, who have received 140 units of UCB in 102 transplants. This Bank of UCB ranks second in the world in productivity according to the rate of utility of units in transplantation (3.3%).
  
  
  CONCLUSIONS
  Our bank of UCB has been able to develop a cell line (hematopoietic stem cells) with international quality standards and has been beneficial for patients served by our institution with need of a transplant mainly in hemato-oncologic patients.
authors.affiliation: Banco Central de Sangre, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal. angel.guerra@imss.gob.mx.
authors.forename: Karina
authors.initials: K
authors.lastname: Peñaflor-Juárez
authors.forename: Sonia Marilyn
authors.initials: SM
authors.lastname: Guillén-Chan
authors.forename: Yanín
authors.initials: Y
authors.lastname: Romero-Juárez
authors.forename: Fernando
authors.initials: F
authors.lastname: Luna-Bautista
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Franco-Gutiérrez
authors.forename: Jesús Salvador
authors.initials: JS
authors.lastname: Arellano-Ocampo
authors.forename: Rocío
authors.initials: R
authors.lastname: Ibáñez-Sánchez
authors.forename: María
authors.initials: M
authors.lastname: de Lourdes Domínguez-Contreras
authors.forename: Angel
authors.initials: A
authors.lastname: Guerra-Márquez
mesh_terms: D000047:Academies and Institutes; D000293:Adolescent; D000328:Adult; D001771:Blood Banks / Q000706:statistics & numerical data*; D001782:Blood Donors / Q000706:statistics & numerical data* / Q000600:supply & distribution; D036101:Cord Blood Stem Cell Transplantation / Q000706:statistics & numerical data*; D046148:Donor Selection / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D005312:Fetal Blood / Q000637:transplantation*; D006801:Humans; D007231:Infant, Newborn; D008800:Mexico; D011247:Pregnancy; D012943:Social Security; D055815:Young Adult
keywords: Cord blood banking; Hematopoietic stem cells; Transplantation