title: Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.
abstract: Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and 2,788 controls and then carried forward the promising variants for replication in another 2 independent sets (2,542 cases and 3,620 controls in total). We identified three new susceptibility loci below the genome-wide significance threshold (P < 5 × 10(-8)) in the combined analyses: 10p12.31 (rs2359536, P(meta) = 2.25 × 10(-10) and rs10828088, P(meta) = 6.27 × 10(-10)), 10q21.1 (rs10763170, P(meta) = 6.88 × 10(-10)) and 13q12.13 (rs17083838, P(meta) = 1.89 × 10(-8)). This study is the first GWAS to our knowledge on sporadic pituitary adenoma, and our results provide insight into the genetic basis of this disease.
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Ming
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authors.lastname: Shen
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Qilin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Li
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Liangfu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Shou
authors.affiliation: 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chen
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Song
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Zengyi
authors.initials: Z
authors.lastname: Ma
authors.affiliation: 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Zhaoyun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] Shanghai Pituitary Tumor Center, Shanghai, China. [2] Department of Endocrinology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Ye
authors.affiliation: Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Chuanxin
authors.initials: C
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: He
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Yichao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xie
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Nidan
authors.initials: N
authors.lastname: Qiao
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Huijia
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Huang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shen
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Zujia
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authors.lastname: Wen
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Wenjin
authors.initials: W
authors.lastname: Li
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Juan
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authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jue
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authors.lastname: Ji
authors.affiliation: Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neuropathology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Haixia
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authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Zhifeng
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authors.lastname: Shi
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Daoying
authors.initials: D
authors.lastname: Geng
authors.affiliation: Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
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authors.affiliation: Department of Radiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tang
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authors.initials: B
authors.lastname: Lu
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authors.lastname: Pan
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
authors.forename: Weimin
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authors.lastname: Bao
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authors.forename: Jinsong
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authors.affiliation: 1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China. [2] Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3] Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China. [4] Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, Shanghai, China. [5] Department of Psychiatry, The First Teaching Hospital of Xinjiang Medical University, Urumqi, China. [6] Shandong Provincial Key Laboratory of Metabolic Disease, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Shi
authors.affiliation: 1] Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. [2] Shanghai Pituitary Tumor Center, Shanghai, China.
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mesh_terms: D000236:Adenoma / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA