title: Nickel-catalyzed reductive arylation of activated alkynes with aryl iodides.
abstract: The direct, regioselective, and stereoselective arylation of activated alkynes with aryl iodides using a nickel catalyst and manganese reductant is described. The reaction conditions are mild (40 °C in MeOH, no acid or base) and an intermediate organomanganese reagent is unlikely. Functional groups tolerated include halides and pseudohalides, free and protected anilines, and a benzyl alcohol. Other activated alkynes including an amide and a ketone also reacted to form arylated products in good yields.
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
authors.forename: Stephanie C M
authors.initials: SC
authors.lastname: Dorn
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Olsen
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Kelemen
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
authors.forename: Ruja
authors.initials: R
authors.lastname: Shrestha
authors.affiliation: Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester, NY 14627, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weix
keywords: alkyne; arylation; catalyzed; nickel; reductive