title: [Effect of epigallocatechin gallate against exercise-induced fatigue in mice].
abstract: OBJECTIVE
  To investigate the effects of epigallocatechin gallate (EGCG)against exercise-induced fatigue in mice.
  
  
  METHODS
  Total 120 mice were randomly divided into three groups and tested separately. For each test, there were 30 mice subdivided into high dose (50 mg/kg . d EGCG) and low dose (10 mg/kg . d EGCG) groups as well as saline control group(1 ml/kg . d) with 10 in each. Burden swimming, running wheel endurance, stick climbing and hypoxia tolerance exercise were used to establish fatigue mice training model in three groups. And intraperitoneal injection with different doses of EGCG per day for consecutively 28 days and the mice in the control group were treated with normal saline. After the last each test, the blood lactic acid (BLA), blood urea nitrogen (BUN), blood lactate dehydrogenase (LDH), muscle glycogen (MG) and liver glycogen (LG) of each group of mice were determined.
  
  
  RESULTS
  EGCG treatment groups(B and C)revealed a prolonged the mice survival time of burden swimming test, hypoxia tolerance, running wheel time and the ability of stick climbing(P < 0.05 or P <0.01), and increased LDH activity and MG and LG contents, reduced contents of BLA and BUN. High dose group had an obviously increase effect than lower dose group(P <0.05).
  
  
  CONCLUSIONS
  EGCG has significant effects against exercise-induced fatigue in mice.
authors.forename: Cheng-yin
authors.initials: CY
authors.lastname: Wang
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Pan
authors.forename: Hui
authors.initials: H
authors.lastname: Li
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D017079:Exercise Tolerance; D005221:Fatigue / Q000188:drug therapy*; D006003:Glycogen / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D051379:Mice; D010805:Physical Conditioning, Animal
chemical_list: D002392:Catechin; D006003:Glycogen; C045651:epigallocatechin gallate; D007770:L-Lactate Dehydrogenase