title: Relationship between vitamin D status and immunosuppressive therapy in kidney transplant recipients.
abstract: There is a growing body of evidence for the protective role of vitamin D in diabetes mellitus (DM), infection, cancer, cardiovascular disease, immune disorders and kidney function. Considering the reported high prevalence of vitamin D insufficiency among kidney transplant recipients (KTRs), the aim of this study was to assess the influence of immunosuppressive therapy and other factors on vitamin D status in such patients. The study included 289 KTRs (189 males and 100 females) who consented to participate. The first test for 25-hydrohyvitamin D [25(OH)D] was performed by a validated liquid chromatography-tandem mass spectrometry method. Influence of immunosuppressive drugs and previously reported predictors on vitamin D status was assessed by descriptive statistics, univariate and multivariate regression. Our results showed that only 53 patients (18.34%) of the studied KTRs were vitamin D sufficient. In addition to a well expected positive association between serum 25(OH)D and summer blood sampling (p< 0.05) and inverse relationship between vitamin D status and DM, gender (female) and body mass index, serum 25(OH)D was found to be inversely associated with calcineurin inhibitors (CNI) (p< 0.05) and unaffected by other immunosuppressive agents. Our study demonstrated high prevalence of vitamin D insufficiency after kidney transplantation in the studied cohort of patients. Apart from female gender, winter months, DM and overweight, the use of CNI could be considered an additional significant predictor of lower 25(OH)D in Bulgarian KTRs.
authors.affiliation: Department of Nephrology and Transplantation, University Hospital 'Alexandrovska', Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Jean Jeanov
authors.initials: JJ
authors.lastname: Filipov
authors.affiliation: Department of Nephrology and Transplantation, University Hospital 'Alexandrovska', Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Borelli Kirilov
authors.initials: BK
authors.lastname: Zlatkov
authors.affiliation: Department of Nephrology and Transplantation, University Hospital 'Alexandrovska', Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Emil Paskalev
authors.initials: EP
authors.lastname: Dimitrov
authors.affiliation: Laboratory of Therapeutic Drug Management & Clinical Pharmacology, University Hospital 'Alexandrovska', Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Dobrin
authors.initials: D
authors.lastname: Svinarov
keywords: 25-hydroxyvitamin D; calcineurin inhibitors; immunosuppressive agents; renal transplantation