title: Parathyroid Hormone is Related to Dysplasia and a Higher Rate of Distal Colorectal Adenoma in Women but Not Men.
abstract: Molecular and clinical observations provide evidence for a potential role of parathyroid hormone (PTH) in colorectal cancer development. We therefore aimed to assess the association of PTH with regard to colorectal cancer precursor lesions. A cohort of 1432 participants, 777 men, 58.4 ± 9.6 years and 701 women, 59.1 ± 10.6 years, undergoing screening colonoscopy were allocated to PTH serum concentrations either above or below 55 ng/L. The number, localization, size, and histology of the polypoid lesions detected during screening colonoscopy were recorded according to PTH serum concentrations. Serum PTH concentrations were not different between men and women. Women with PTH serum concentrations above the cut-off had significantly more adenomas (13/40; 32.5%) of the distal colon compared to women below the cut-off (91/659; 13.8%; P = 0.001). Additionally, the rate of dysplasia in adenomas of the distal colon was higher in women with high compared to low PTH concentrations (P = 0.001). These findings remained robust after adjustments for serum vitamin D, age, plasma creatinine, BMI, diabetes, and liver steatosis. No associations were observed between serum PTH concentrations and colorectal lesions in men. These data suggest that elevated PTH serum concentrations might have a role in colorectal cancer development as indicated by higher rates of adenomas, specifically with dysplasia, in women. The role of PTH in colon carcinogenesis and its sex specificity deserve further study.
authors.affiliation: Department of Internal Medicine, Oberndorf Hospital, Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.
authors.forename: Elmar
authors.initials: E
authors.lastname: Aigner
authors.forename: Andreas
authors.initials: A
authors.lastname: Stadlmayr
authors.forename: Ursula
authors.initials: U
authors.lastname: Huber-Schönauer
authors.forename: Jochen
authors.initials: J
authors.lastname: Zwerina
authors.forename: Emma
authors.initials: E
authors.lastname: Husar-Memmer
authors.forename: David
authors.initials: D
authors.lastname: Niederseer
authors.forename: Sebastian K
authors.initials: SK
authors.lastname: Eder
authors.forename: Felix
authors.initials: F
authors.lastname: Stickel
authors.forename: Christian
authors.initials: C
authors.lastname: Pirich
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Patsch
authors.forename: Christian
authors.initials: C
authors.lastname: Datz
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000378:metabolism*; D015331:Cohort Studies; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000378:metabolism*; D005877:Gigantism / Q000378:metabolism*; D006330:Heart Defects, Congenital / Q000378:metabolism*; D006801:Humans; D008607:Intellectual Disability / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D010281:Parathyroid Hormone