title: A cohort study evaluating the role of surgery for lung metastases from colorectal cancer.
abstract: OBJECTIVE
  Surgery may be curative in some patients with metastatic colorectal cancer (mCRC). We analyzed the role of lung metastatectomy in this population.
  
  
  METHODS
  In this retrospective cohort study, cases were defined as mCRC patients with lung metastases (LM's) who underwent metastatectomy. Controls had LM's but did not undergo resection.
  
  
  RESULTS
  There were 28 cases and 46 controls. The median overall survival (OS) was 53 months among the cases and 26.3 months for the controls. The cases were more likely to have 1 or 2 lung metastases, unilateral versus bilateral LM's, metachronous versus synchronous presentation of LM's and more likely to have a carcinoembryonic antigen (CEA) level less than 10 ng/ml at diagnosis. The interval from diagnosis to the development of lung metastases was significantly longer in cases versus controls (22.9 versus 8.5 months).
  
  
  CONCLUSIONS
  Patients selected using these criteria may have prolonged survival with therapy that includes lung metastatectomy.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, U.S.A.
authors.forename: Francisco
authors.initials: F
authors.lastname: Socola
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, U.S.A.
authors.forename: Dao M
authors.initials: DM
authors.lastname: Nguyen
authors.affiliation: Chen Medical Centers, Miami, FL, U.S.A.
authors.forename: Roberto E
authors.initials: RE
authors.lastname: Ochoa
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL, U.S.A.
authors.forename: Caio M
authors.initials: CM
authors.lastname: Rocha Lima
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY, U.S.A. Peter.Hosein@uky.edu.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hosein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic
keywords: Colorectal cancer; chemotherapy; prognostic factors; surgery