title: [The results of combined ozone therapy using in complex treatment of soft tissues infections in patients with diabetes mellitus type II].
abstract: Levels of interleukins-6, 8, 10, TNF-alpha and basic fibroblast growth factor (bFGF) were examined in peripheral blood of 60 patients with diabetes mellitus type II and soft tissues infections. It was revealed the elevated levels of proinflammatory (IL-6, 8), anti-inflammatory (IL-10) cytokines and basic fibroblast growth factor at the time of admission. Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum. Thus effective local bactericidal impact of ozone in combination with normalization of proinflammatory cytokines levels and preserved high level of bFGF in peripheral blood provide better results of wound healing process in patients with diabetes mellitus type II.
authors.affiliation: Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: Iu S
authors.initials: IS
authors.lastname: Vinnik
authors.affiliation: Kafedra biokhimii s kursami meditsinskoĭ, farmatsevticheskoĭ i toksikologicheskoĭ khimii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.affiliation: Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: O V
authors.initials: OV
authors.lastname: Tepliakova
authors.affiliation: Kafedra obshcheĭ khirurgii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: A I
authors.initials: AI
authors.lastname: Drobushevskaia
authors.affiliation: Kafedra biokhimii s kursami meditsinskoĭ, farmatsevticheskoĭ i toksikologicheskoĭ khimii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: E A
authors.initials: EA
authors.lastname: Pozhilenkova
authors.affiliation: Kafedra biokhimii s kursami meditsinskoĭ, farmatsevticheskoĭ i toksikologicheskoĭ khimii Nauchno-issledovatel'skogo instituta molekuliarnoĭ meditsiny i patobiokhimii Krasnoiarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Voĭno-Iasenetskogo.
authors.forename: A V
authors.initials: AV
authors.lastname: Morgun
authors.affiliation: Institut poliklinicheskoĭ meditsiny, Krasnoiarsk.
authors.forename: M V
authors.initials: MV
authors.lastname: Shapran
authors.affiliation: Institut poliklinicheskoĭ meditsiny, Krasnoiarsk.
authors.forename: A O
authors.initials: AO
authors.lastname: Kovalenko
mesh_terms: D000368:Aged; D001804:Blood Transfusion, Autologous / Q000379:methods*; D016207:Cytokines / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000627:therapeutic use; D010126:Ozone / Q000627:therapeutic use*; D018461:Soft Tissue Infections / Q000097:blood / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D016207:Cytokines; D010083:Oxidants, Photochemical; D010126:Ozone