title: Advances in measuring single-cell pharmacology in vivo.
abstract: Measuring key pharmacokinetic and pharmacodynamic parameters in vivo at the single cell level is likely to enhance drug discovery and development. In this review, we summarize recent advances in this field and highlight current and future capabilities.
authors.affiliation: Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address: cvinegoni@mgh.harvard.edu.
authors.forename: Claudio
authors.initials: C
authors.lastname: Vinegoni
authors.affiliation: Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA.
authors.forename: J Matthew
authors.initials: JM
authors.lastname: Dubach
authors.affiliation: Department of Chemical Engineering, Department of Biomedical Engineering, University of Michigan, 2300 Hayward Avenue, Ann Arbor, MI 48109, USA.
authors.forename: Greg M
authors.initials: GM
authors.lastname: Thurber
authors.affiliation: Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA.
authors.forename: Miles A
authors.initials: MA
authors.lastname: Miller
authors.affiliation: Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA.
authors.forename: Ralph
authors.initials: R
authors.lastname: Mazitschek
authors.affiliation: Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA.
authors.forename: Ralph
authors.initials: R
authors.lastname: Weissleder
mesh_terms: D000818:Animals; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology; D059010:Single-Cell Analysis / Q000379:methods*