title: Next-generation nanoantibacterial tools developed from peptides.
abstract: Bacteria resistant against various antimicrobial compounds have emerged in many countries, and the age of resistance has just started. Among the more promising novel antimicrobial compounds on which current research is focusing are the antimicrobial peptides (AMPs). These are often less susceptible to bacterial resistance since multiple modifications in the cellular membranes, cell wall and metabolism are required to reduce their effectiveness. Most likely, the use of pure AMPs will be insufficient for controlling pathogenic bacteria, and innovative approaches are required to employ AMPs in new antibiotic treatments. Therefore, here we review novel bionanotechnological approaches, including nanofibers, nanoparticles and magnetic particles for effectively using AMPs in fighting infectious diseases.
authors.affiliation: 2Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, PO Box 196, 9700 AD Groningen, The Netherlands.
authors.forename: Renko de
authors.initials: Rd
authors.lastname: Vries
authors.affiliation: 3Departamento de Bioquímica e Programa de Pós-Graduação em Inovação Terapêutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil.
authors.forename: Cesar A S
authors.initials: CA
authors.lastname: Andrade
authors.affiliation: 4Instituto de Física, Universidade Federal de Goiás, 74001-970, Goiânia, GO, Brazil.
authors.forename: Andris F
authors.initials: AF
authors.lastname: Bakuzis
authors.affiliation: 5Anti-Infective Research Lab, Department of Microbiology, Vidyasagar University, Midnapore 721102, West Bengal, Índia.
authors.forename: Santi M
authors.initials: SM
authors.lastname: Mandal
authors.affiliation: 6Centro de Análises, Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70790-160, Brazil.|7S-Inova, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil.
authors.forename: Octavio L
authors.initials: OL
authors.lastname: Franco
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D008969:Molecular Sequence Data; D049329:Nanostructures; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides
keywords: antimicrobial peptides; bacterial resistance; biofilms; magnetic particles; nanofibers; nanoparticles