title: Domain position prediction based on sequence information by using fuzzy mean operator.
abstract: The prediction of protein domain region is an advantageous process on the study of protein structure and function. In this study, we proposed a new method, which is composed of fuzzy mean operator and region division, to predict the particular positions of domains in a target protein based on its sequence. The whole sequence is aligned and scored by using fuzzy mean operator, and the final determination of domain region position is realized by region division. A published benchmark is used for the comparison with previous researches. In addition, we generate two extra datasets to examine the stability of this method. Finally, the prediction accuracy of independent test dataset achieved by our method was up to 84.13%. We wish that this method could be useful for related researches.
authors.affiliation: Chemical Information Center (CIC), College of Chemistry, Sichuan University, Chengdu, 610064, China.
authors.forename: Runyu
authors.initials: R
authors.lastname: Jing
authors.affiliation: Chemical Information Center (CIC), College of Chemistry, Sichuan University, Chengdu, 610064, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.affiliation: Chemical Information Center (CIC), College of Chemistry, Sichuan University, Chengdu, 610064, China.
authors.forename: Yuelong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Chemical Information Center (CIC), College of Chemistry, Sichuan University, Chengdu, 610064, China.
authors.forename: Menglong
authors.initials: M
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D030562:Databases, Protein; D000069550:Machine Learning; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*
chemical_list: D011506:Proteins
keywords: Cd-hit; PSI-BLAST; Uniprot; region division; template-based method