title: Variation of Magnetic Particle Imaging Tracer Performance With Amplitude and Frequency of the Applied Magnetic Field.
abstract: The magnetic response of magnetic particle imaging (MPI) tracers varies with the slew rate of the applied magnetic field, as well as with the tracer's average magnetic core size. Currently, 25 kHz and 20 mT/μ0drive fields are common in MPI, but lower field amplitudes may be necessary for patient safety in future designs. We studied how several different sizes of monodisperse MPI tracers behaved under different drive field amplitude and frequency, using magnetic particle spectrometry and ac hysteresis for drive field conditions at 16, 26, and 40 kHz, with field amplitudes from 5 to 40 mT/μ0. We observed that both field amplitude and frequency can influence the tracer behavior, but that the magnetic behavior is consistent when the slew rate (the product of field amplitude and frequency) is consistent. However, smaller amplitudes provide a correspondingly smaller field of view, sometimes resulting in excitation of a minor hysteresis loop.
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195 USA.
authors.forename: Asahi
authors.initials: A
authors.lastname: Tomitaka
authors.affiliation: LodeSpin Labs, Seattle, WA 98145 USA.
authors.forename: Richard Matthew
authors.initials: RM
authors.lastname: Ferguson
authors.affiliation: LodeSpin Labs, Seattle, WA 98145 USA.
authors.forename: Amit P
authors.initials: AP
authors.lastname: Khandhar
authors.affiliation: LodeSpin Labs, Seattle, WA 98145 USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Kemp
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Electrical and Computer Engineering, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takemura
authors.affiliation: Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195 USA.
authors.forename: Kannan M
authors.initials: KM
authors.lastname: Krishnan
keywords: AC hysteresis; MPI tracers; iron oxide nanoparticles; magnetic particle imaging (MPI); magnetic particle spectrometry (MPS)