title: Anti-inflammatory Activity of Pyrrolizidine Alkaloids from the Leaves of Madhuca pasquieri (Dubard).
abstract: A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.
authors.affiliation: College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu.
authors.forename: Le Son
authors.initials: le S
authors.lastname: Hoang
authors.forename: Manh Hung
authors.initials: MH
authors.lastname: Tran
authors.forename: Joo Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Dao Cuong
authors.initials: DC
authors.lastname: To
authors.forename: Van Thu
authors.initials: VT
authors.lastname: Nguyen
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Jeong Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Woo
authors.forename: Byung Sun
authors.initials: BS
authors.lastname: Min
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D032128:Madhuca / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D009569:Nitric Oxide / Q000276:immunology; D018515:Plant Leaves / Q000737:chemistry; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D011763:Pyrrolizidine Alkaloids; D009569:Nitric Oxide