title: Cardiovascular target organ damage could have been detected in sustained pediatric hypertension.
abstract: The aim of this study was to assess sustained hypertension in children and its impact on cardiovascular target organ damage (TOD). Blood pressure (BP) was measured in children in Beijing in 2009. Primary hypertension was diagnosed based on three separate visits. Hypertensive children and normotensive children were followed up in 2011. According to these evaluations, three groups were defined: sustained hypertension, non-sustained hypertension and normotensive. Cardiovascular TOD and metabolic disorders were evaluated using pulse-wave velocity (PWV), carotid intima-media thickness (cIMT), and assessments of left ventricular structure and kidney function. A total of 3032 children aged 9-15 years participated in this survey, of whom 128 were diagnosed with hypertension after three separate BP measurements. Eighty out of 128 (62.5%) hypertensive and 158 normotensive children were available for follow-up in 2011. Forty-eight children were defined as having sustained hypertension, 38 as non-sustained hypertension and 152 as normotensive. Mean levels of brachial-ankle PWV (baPWV), left ventricular mass, left ventricular mass index (LVMI) and cIMT were significantly different between the three groups (p < 0.01). Compared to normotensives, the odds ratios and 95% confidence intervals for elevated LVM and cIMT were 5.27 (1.57-17.66) and 2.88 (1.03-8.09) in the non-sustained hypertensive group, and 3.28 (1.00-10.74) and 7.25 (2.69-19.58) in the sustained hypertensive group. The children with sustained hypertension have the highest risk of developing arterial stiffness, left ventricular hypertrophy and early blood vessel endothelium damage. The indices of cIMT, LVMI and PWV were useful to identify children at high risk of cardiovascular TOD.
authors.affiliation: Department of Epidemiology, Capital Institute of Pediatrics , Beijing , PR China.
authors.forename: Linghui
authors.initials: L
authors.lastname: Meng
authors.forename: Dongqing
authors.initials: D
authors.lastname: Hou
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuehua
authors.initials: Y
authors.lastname: Hu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Liang
authors.forename: Junting
authors.initials: J
authors.lastname: Liu
authors.forename: Yinkun
authors.initials: Y
authors.lastname: Yan
authors.forename: Jie
authors.initials: J
authors.lastname: Mi
mesh_terms: D000293:Adolescent; D000068476:Beijing / Q000453:epidemiology; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D002648:Child; D005260:Female; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D059289:Vascular Stiffness
keywords: Children and adolescents; hypertension; target organ damage