title: Impact of a pharmacotherapy plan to improve adherence for patients with type-2 diabetes and hypertension in a Chilean hospital.
abstract: BACKGROUND
  Non-adherence to prescribed treatment is a principle cause of treatment failure in patients with chronic diseases, such as type 2 diabetes mellitus (T2DM) and hypertension. Improved patient monitoring and education have been shown to improve adherence and clinical outcomes.
  
  
  OBJECTIVE
  This study evaluates the impact of a pharmacotherapy optimization plan centered on patient education that was implemented at a hospital in Arauco, Chile.
  
  
  METHODS
  A prospective study was conducted using 50 randomly selected patients diagnosed with both T2DM and hypertension. Each patient participated in three successive interview sessions over 6 months. At each session, the following variables were evaluated by a pharmacist: blood pressure, HbA1c, adherence to prescribed medication, and patient knowledge of disease.
  
  
  RESULTS
  Significant decreases were observed for HbA1c (<0.001), and SBP (<0.001), with stronger and more significant decreases observed for females. Patient adherence to prescribed medication also improved, but not significantly. The number of patients with full knowledge of their diseases increased significantly (p < 0.001) from 10 to 66%.
  
  
  CONCLUSIONS
  This study suggests that the incorporation of a pharmacotherapeutic optimization plan for patients with chronic diseases can have a positive impact on the control of chronic diseases, such as T2DM and hypertension.
authors.affiliation: CESFAM Bicentenario, Arauco, Chile.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Soto
authors.affiliation: Pharmacovigilance Unit, San Vicente Hospital, Arauco, Chile.
authors.forename: Ximena
authors.initials: X
authors.lastname: Avila
authors.affiliation: Facultad de Farmacia, Universidad de Concepción, Barrio Universitario, 4030000, Concepción, Chile.
authors.forename: Pia
authors.initials: P
authors.lastname: Cordova
authors.affiliation: Facultad de Farmacia, Universidad de Concepción, Barrio Universitario, 4030000, Concepción, Chile.
authors.forename: Pola
authors.initials: P
authors.lastname: Fernandez
authors.affiliation: Facultad de Farmacia, Universidad de Concepción, Barrio Universitario, 4030000, Concepción, Chile.
authors.forename: Mariela
authors.initials: M
authors.lastname: Lopez
authors.affiliation: Facultad de Farmacia, Universidad de Concepción, Barrio Universitario, 4030000, Concepción, Chile.
authors.forename: Lorenzo A
authors.initials: LA
authors.lastname: Villa
authors.affiliation: Facultad de Farmacia, Universidad de Concepción, Barrio Universitario, 4030000, Concepción, Chile. felimora@udec.cl.
authors.forename: Felipe
authors.initials: F
authors.lastname: Morales
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002677:Chile; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006442:Glycated Hemoglobin / Q000187:drug effects; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy* / Q000523:psychology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D010595:Pharmacists; D024382:Professional Role; D011446:Prospective Studies
chemical_list: D000959:Antihypertensive Agents; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; C517652:hemoglobin A1c protein, human
keywords: Chile; Medication adherence; Patient education; Pharmacotherapeutic optimization plan