title: Long-term survival of a breast cancer patient with extensive liver metastases upon immune and virotherapy: a case report.
abstract: Liver metastases in breast cancer are associated with a poor prognosis. We report long-term survival of a patient with breast cancer and liver metastases. After operation the patient declined further standard therapy. Instead, she was treated with local hyperthermia, Newcastle disease virus and dendritic cell vaccination at the Immunological and Oncological Center Cologne (IOZK), Germany. A continuous high quality of life was reported and the patient survived more than 66 months after initial diagnosis. No recurrence or further metastases developed under treatment. Following treatment, a long-lasting tumor-reactive memory T-cell responsiveness could be documented. This possibly explains the favorable course of disease. Since this combination of therapies is not restricted to a particular tumor type, further exploration is warranted.
authors.affiliation: Immunological & Oncological Center, 30-32 Hohenstaufenring, Cologne D-50674, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Schirrmacher
authors.affiliation: Immunological & Oncological Center, 30-32 Hohenstaufenring, Cologne D-50674, Germany.
authors.forename: Wilfried
authors.initials: W
authors.lastname: Stücker
authors.affiliation: Immunological & Oncological Center, 30-32 Hohenstaufenring, Cologne D-50674, Germany.
authors.forename: Maria
authors.initials: M
authors.lastname: Lulei
authors.affiliation: Immunological & Oncological Center, 30-32 Hohenstaufenring, Cologne D-50674, Germany.
authors.forename: Akos-Sigmund
authors.initials: AS
authors.lastname: Bihari
authors.affiliation: Immunological & Oncological Center, 30-32 Hohenstaufenring, Cologne D-50674, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Sprenger
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D011788:Quality of Life; D017741:Survivors; D016896:Treatment Outcome
keywords: Newcastle disease virus; breast cancer; dendritic cell vaccination; hyperthermia; immunotherapy