title: [Preparation and formulation investigation of gastric retention calcium alginate microspheres containing Brucea javanica oil].
abstract: OBJECTIVE
  To investigate the preparation technologies of gastric retention calcium alginate microsphere containing Brucea javanica oil, and to evaluate its formulations.
  
  
  METHODS
  The formulations of gastric retention calcium alginate microspheres were optimized with G/M ration and concentration of sodium alginate,use level of iron calcium solution and pore-forming agent, cross-link time and pH value of cross-link solution, which had shown a great effect on microspheres morphology, drug release behavior, drug loaded and encapsulation efficiency.
  
  
  RESULTS
  Brucea javanica oil alginate microspheres looked spherical, homogeneous and well distributive. And the drug loaded of Brucea javanica oil was over 40%, encapsulation efficiency was over 70%.
  
  
  CONCLUSIONS
  The prepared gastric retention calcium alginate microspheres have a great sustained release and floating capability, which can provide a strong topical therapy for gastric diseases.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xi-tong
authors.initials: XT
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Yu-jiao
authors.initials: YJ
authors.lastname: Yan
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000464:Alginates / Q000737:chemistry*; D032269:Brucea / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D010316:Particle Size; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D010938:Plant Oils; D020723:Glucuronic Acid