title: Spontaneous and bilateral necrosis of the femoral head in a young experimental beagle dog.
abstract: This report describes the pathological characterizations of a rare case of necrosis of the femoral head that was spontaneous, bilateral, avascular and nontraumatic. A 14-month-old beagle dog was presented with pain in the hind limbs. At necropsy, the articular surface in the bilateral femoral head was markedly irregular. There were no gross abnormalities other than in the hip joints. Microscopically, a wide range of trabecular bone necrosis localized in the subchondral area was observed in both femoral heads. In the right femoral head, fibrosis and proliferative vessels were noted in the subchondral area. The articular cartilage was thickened irregularly, but there was no evidence of cartilage necrosis. The bone marrow adjacent to the affected area showed severe depression. In the metaphysis, atrophic bone marrow, but not bone necrosis, was observed. This was a rare case of spontaneous necrosis of the femoral head in an experimental beagle dog.
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kurotaki
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Shino
authors.initials: S
authors.lastname: Kumabe
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Wako
authors.affiliation: Pathology Department, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
keywords: Legg-Calvé-Perthes disease; avascular osteonecrosis; dog; necrosis of the femoral head; spontaneous lesion