title: Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: a comparative study.
abstract: OBJECTIVE
  This prospective study was done to evaluate and compare the utility and effectiveness of platelet rich fibrin (PRF) with that of platelet rich plasma (PRP) on soft tissue healing and bone tissue healing of extracted third molar sockets.
  
  
  METHODS
  This study included split mouths of 20 patients who underwent bilateral extraction of impacted third molars. During the same appointment, following which PRF and PRP were prepared from patients' autologous blood and placed in right and left extracted sockets, respectively. The data for soft tissue healing were recorded at end of 1 week, using healing index of Landry et al. and the data for bone tissue healing were recorded at the end of 4 months using digitalized orthopantomogram images on Adobe Photoshop CS; which was then compared between the two sites of the same patient.
  
  
  RESULTS
  The mean values of soft tissue healing collected at 1 week post-operative, for PRF group were significantly higher as compared to PRP group. And the mean values of bone density collected at the end of fourth month post-operative, for PRF group were also significantly higher as compared to PRP group. Both tests showed p value of 0.00.
  
  
  CONCLUSIONS
  PRF is significantly better in promoting soft tissue healing and also faster regeneration of bone after third molar extraction, in comparison with PRP. This could be attributed to simpler preparation protocols of PRF over PRP and the ability of PRF to release growth factors in a controlled way.
authors.affiliation: Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, JSS University, S.S. Nagar, Mysore, 5700-15 India.
authors.forename: Tejesh
authors.initials: T
authors.lastname: Yelamali
authors.affiliation: Department of Oral and Maxillofacial Surgery, JSS Dental College and Hospital, JSS University, S.S. Nagar, Mysore, 5700-15 India.
authors.forename: D
authors.initials: D
authors.lastname: Saikrishna
keywords: Growth factors; PRF; PRP; Third molar extraction; Wound healing