title: Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes.
abstract: Some new Zn(II) and Cu(II) complexes [Cu(L1)(OAc)2]∙H2O, [Cu(L1)(NO3)H2O]∙NO3∙3.5H2O, [Zn(L1)(NO3)2]∙4.5H2O, [Zn(L1)(OAc)2(H2O)2]∙3H2O, [Cu2(L2)(OAc)4]∙2H2O∙2DMF, [Cu(L2)2]∙2NO3∙1.5DMF∙H2O, [Zn(L2)2(NO3)2]∙DMF and [Zn2(L2)(OAc)4(H2O)4]∙5H2O; L1 = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L2 = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, 1H-NMR,13C-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Muş Alparslan University, 49250 Muş, Turkey. nevintrn@hotmail.com.
authors.forename: Nevin
authors.initials: N
authors.lastname: Turan
authors.affiliation: Nursing Department, School of Health, Muş Alparslan University, 49250 Muş, Turkey. h.korkoca@alparslan.edu.tr.
authors.forename: Hanifi
authors.initials: H
authors.lastname: Körkoca
authors.affiliation: Department of Chemical Engineering, Faculty of Engineering, Tunceli University, 62000 Tunceli, Turkey. radiguzel@tunceli.edu.tr.
authors.forename: Ragıp
authors.initials: R
authors.lastname: Adigüzel
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Hitit University, 19100 Çorum, Turkey. nakicolak@hitit.edu.tr.
authors.forename: Naki
authors.initials: N
authors.lastname: Çolak
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Muş Alparslan University, 49250 Muş, Turkey. k.buldurun@alparslan.edu.tr.
authors.forename: Kenan
authors.initials: K
authors.lastname: Buldurun
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D003512:Cyclohexanones / Q000138:chemical synthesis / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology*; D008024:Ligands; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D015032:Zinc / Q000737:chemistry
chemical_list: C000605291:2-(2-(2-methoxyphenyl)hydrazono)cyclohexane-1,3-dione; C000605292:2-(2-(3-nitrophenyl)hydrazono)cyclohexane-1,3-dione; D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D003512:Cyclohexanones; D006835:Hydrazones; D008024:Ligands; C036468:cyclohexanone; D003300:Copper; D015032:Zinc
keywords: antibacterial activity; cyclohexane-1,3-dione; mass spectra; metal complexes; spectroscopic characterization