title: The relationship between body mass index and uric acid: a study on Japanese adult twins.
abstract: OBJECTIVE
  The present study aimed to investigate the association between body mass index (BMI) and uric acid (UA) using the twin study methodology to adjust for genetic factors.
  
  
  METHODS
  The association between BMI and UA was investigated in a cross-sectional study using data from both monozygotic and dizygotic twins registered at the Osaka University Center for Twin Research and the Osaka University Graduate School of Medicine. From January 2011 to March 2014, 422 individuals participated in the health examination. We measured height, weight, age, BMI, lifestyle habits (Breslow's Health Practice Index), serum UA, and serum creatinine. To investigate the association between UA and BMI with adjustment for the clustering of a twin within a pair, individual-level analyses were performed using generalized linear mixed models (GLMMs). To investigate an association with adjustment for genetic and family environmental factors, twin-pair difference values analyses were performed.
  
  
  RESULTS
  In all analysis, BMI was associated with UA in men and women. Using the GLMMs, standardized regression coefficients were 0.194 (95 % confidence interval: 0.016-0.373) in men and 0.186 (95 % confidence interval: 0.071-0.302) in women. Considering twin-pair difference value analyses, standardized regression coefficients were 0.333 (95 % confidence interval: 0.072-0.594) in men and 0.314 (95 % confidence interval: 0.151-0.477) in women.
  
  
  CONCLUSIONS
  The present study shows that BMI was significantly associated with UA, after adjusting for both genetic and familial environment factors in both men and women.
authors.affiliation: Department of Community Health Nursing, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan, ktanaka@gifu-u.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Soshiro
authors.initials: S
authors.lastname: Ogata
authors.forename: Haruka
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kayoko
authors.initials: K
authors.lastname: Omura
authors.forename: Chika
authors.initials: C
authors.lastname: Honda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D014527:Uric Acid / Q000097:blood*; D055815:Young Adult
chemical_list: D014527:Uric Acid