title: Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques.
abstract: Here we present a case series from a primate research facility. The index case, a 4-year-old pig-tailed macaque (Macaca nemestrina) experimentally infected with chimeric simian-human immunodeficiency virus (SHIVSF162 P4), developed weight loss and was euthanized. Based on necropsy results the animal was diagnosed with opportunistic atypical mycobacteriosis associated with simian AIDS (SAIDS). Subsequently, tissues from the index animal, as well as tissues and oral mucosal swabs from six SHIV-infected contacts, were analyzed using molecular methods and found to contain nucleic acid sequences characteristic of Mycobacterium tuberculosis complex (MTBC). These data suggest that existing protocols fail to reliably detect MTBC infection in laboratory primates used as experimental models.
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA ; Swedish/Cherry Hill Family Medicine , Seattle 98122, WA, USA.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Engel
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
authors.forename: Alicia K
authors.initials: AK
authors.lastname: Wilbur
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Westmark
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
authors.forename: Dara
authors.initials: D
authors.lastname: Horn
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones-Engel
keywords: atypical mycobacteriosis; coinfection; IS6110; Macaca; MTBC; pig-tailed macaque; SHIVSF162 P4