title: Demonstration of a Borst-Jadassohn-Like Phenomenon in Sebaceous Carcinoma of the Eyelid.
abstract: A 77-year-old male presented with a diffuse, papular erythematous conjunctival mass that demonstrated on pathologic examination lobules of tumor in the conjunctival substantia propria and tarsus. The cells displayed numerous cytoplasmic vacuoles with extreme nuclear pleomorphism, consistent with sebaceous carcinoma. The overlying palpebral conjunctival epithelium exhibited regions of carcinoma in situ containing some vacuolated cells, alternating with a more classical appearance of pagetoid spread among normal surviving keratinocytes. Further analysis disclosed vesicular positivity for adipophilin and positive nuclear staining for androgen receptor. One tumor focus harbored exaggerated collections of intraepithelial tumor cells. These simulated the Borst-Jadassohn phenomenon of large nests of alien appearing cells normally encountered within the epidermis of the skin. This is the first description of this pattern created by an eyelid sebaceous carcinoma growing within the conjunctival epithelium.
authors.affiliation: *David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary; and †Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stagner
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Jakobiec
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000175:diagnosis*; D000368:Aged; D001706:Biopsy; D003228:Conjunctiva / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000175:diagnosis*; D005143:Eyelids / Q000473:pathology*; D006801:Humans; D008297:Male; D012626:Sebaceous Gland Neoplasms / Q000175:diagnosis*