title: Mediastinal paraganglioma.
abstract: We present a case of mediastinal paraganglioma with radiologic-pathologic correlation. A 48-year-old woman was found incidentally to have a middle mediastinal mass on CT. The mass showed iso-signal intensity compared to that of muscle on T1-weighted images and high signal intensity on T2-weighted images. The lesion showed intermediate intensity on diffusion-weighted imaging, and its apparent diffusion coefficient was 1.72 × 10(-3) mm(2)/s. A contrast-enhanced dynamic study revealed a rapid peak and washout enhancement pattern. (18)F-FDG-PET revealed abnormal uptake in the mediastinal tumor with a maximal standardized uptake value of 7.88. (123)I-meta-iodobenzylguanidine scintigraphy also showed abnormal uptake in the tumor. These findings corresponded to the hypervascularity, rich stroma, low nuclear/cytoplasmic ratio, and nest-forming proliferation of tumor cells with positive neuroendocrine markers.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takashima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamitani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawanami
authors.forename: Michinobu
authors.initials: M
authors.lastname: Nagao
authors.forename: Masato
authors.initials: M
authors.lastname: Yonezawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Baba
authors.forename: Hidetake
authors.initials: H
authors.lastname: Yabuuchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hida
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kohashi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D019797:3-Iodobenzylguanidine; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000473:pathology*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine