title: [Antioxidant properties of cluster rhenium compounds and their effect on erythropoiesis of rats with guerin carcinoma].
abstract: Biochemical characteristics of kidneys, pe- ripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed.
authors.forename: Y S
authors.initials: YS
authors.lastname: Voronkova
authors.forename: S O
authors.initials: SO
authors.lastname: Babiy
authors.forename: L V
authors.initials: LV
authors.lastname: Ivans'kar
authors.forename: O V
authors.initials: OV
authors.lastname: Shtemenko
authors.forename: N I
authors.initials: NI
authors.lastname: Shtemenko
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000819:agonists / Q000096:biosynthesis; D006400:Hematocrit; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D004921:Erythropoietin; D012211:Rhenium; D002945:Cisplatin