title: Microparticulated systems based on chitosan and poly(vinyl alcohol) with potential ophthalmic applications.
abstract: Spherical microparticles for encapsulation of drugs for the treatment of diseases, with a diameter ranging between 2 and 4 µm, were obtained by double crosslinking (ionic and covalent) of chitosan and poly(vinyl alcohol) blend in a water-in-oil emulsion. Microparticles characterisation was carried out in terms of structural, morphological and swelling properties in aqueous media. The presence of chitosan in particles composition confers them a pH-sensitive character. Toxicity and hemocompatibility tests prove the biocompatible character of microparticles. The pilocarpine loading capacity is high as well as the release efficiency which increases up to 72 and 82% after 6 h. The obtained results recommend the microparticles as sustained release drug carriers for the treatment of eye diseases.
authors.affiliation: Faculty of Dental Medicine, "Academician Ioan Hăulică" Research Institute, "Apollonia" University of Iasi , IaÛi , Romania .
authors.forename: Anca Niculina
authors.initials: AN
authors.lastname: Cadinoiu
authors.forename: Catalina Anisoara
authors.initials: CA
authors.lastname: Peptu
authors.forename: Bernard
authors.initials: B
authors.lastname: Fache
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Chailan
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008422:Materials Testing; D051379:Mice; D018721:Muscarinic Agonists / Q000008:administration & dosage* / Q000737:chemistry; D009883:Ophthalmic Solutions / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D010862:Pilocarpine / Q000008:administration & dosage* / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000633:toxicity
chemical_list: D003692:Delayed-Action Preparations; D018721:Muscarinic Agonists; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan; double crosslinking; microparticles; pilocarpine; poly(vinyl alcohol)