title: A new approach to human microRNA target prediction using ensemble pruning and rotation forest.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs that have important functions in gene regulation. Since finding miRNA target experimentally is costly and needs spending much time, the use of machine learning methods is a growing research area for miRNA target prediction. In this paper, a new approach is proposed by using two popular ensemble strategies, i.e. Ensemble Pruning and Rotation Forest (EP-RTF), to predict human miRNA target. For EP, the approach utilizes Genetic Algorithm (GA). In other words, a subset of classifiers from the heterogeneous ensemble is first selected by GA. Next, the selected classifiers are trained based on the RTF method and then are combined using weighted majority voting. In addition to seeking a better subset of classifiers, the parameter of RTF is also optimized by GA. Findings of the present study confirm that the newly developed EP-RTF outperforms (in terms of classification accuracy, sensitivity, and specificity) the previously applied methods over four datasets in the field of human miRNA target. Diversity-error diagrams reveal that the proposed ensemble approach constructs individual classifiers which are more accurate and usually diverse than the other ensemble approaches. Given these experimental results, we highly recommend EP-RTF for improving the performance of miRNA target prediction.
authors.affiliation: * Department of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Mousavi
authors.affiliation: † Department of Computer Engineering, Shahid Bahonar University of Kerman, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Eftekhari
authors.affiliation: * Department of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Mehdi Ghezelbash
authors.initials: MG
authors.lastname: Haghighi
mesh_terms: D000465:Algorithms; D002877:Chromosomes, Human; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008957:Models, Genetic
chemical_list: D035683:MicroRNAs
keywords: MicroRNA target prediction; ensemble pruning; genetic algorithm; rotation forest; weighted majority voting