title: Regulating Tumor Myeloid-Derived Suppressor Cells by MicroRNAs.
abstract: Myeloid-derived suppressor cells (MDSCs) are one of the major cell components responsible for cancer immune evasion. Studying mechanisms associated with the regulation of MDSCs is becoming appreciated as another way to manipulate immune responses. MicroRNAs (miRNAs) have been recognized as substances which may interact with MDSCs, and eight miRNAs including miR-17-5p, miR-20a, miR-223, miR-21, miR-155, miR-494, miR-690 and miR-101 are of particular interest regarding MDSC accumulation and function. We have reviewed the data supporting this activity of these entities.
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China ; Robert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Siqi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Kuzel
authors.affiliation: Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China ; Robert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
keywords: MDSC; immunosuppression; immunotherapy; microRNA; tumor microenvironment