title: Prognostic factors in peptic ulcer perforations: a retrospective 14-year study.
abstract: Regarding the complications of peptic ulcer, a perforation remains the most important fatal complication. The aim of our retrospective study was to determine relations between postoperative morbidity and comorbid disease or perioperative risk factors in perforated peptic ulcer. In total, 239 patients who underwent emergency surgery for perforated peptic ulcer in Ege University General Surgery Department, between June 1999 and May 2013 were included in this study. The clinical data concerning the patient characteristics, operative methods, and complications were collected retrospectively. One hundred seventy-five of the 239 patients were male (73.2%) and 64 were female (26.8%). Mean American Society of Anesthesiologists (ASA) score was 1 in the patients without morbidity, but mean ASA score was 3 in the morbidity and mortality groups. Primary suture and omentoplasty was the selected procedure in 228 of the patients. Eleven patients underwent resection. In total, 105 patients (43.9%) had comorbidities. Thirty-seven patients (67.3%) in the morbidity group had comorbid diseases. Thirteen (92.9%) patients in the mortality group had comorbid diseases. Perforation as a complication of peptic ulcer disease still remains among the frequent indications of urgent abdominal surgery. Among the analyzed parameters, age, ASA score, and having comorbid disease were found to have an effect on both mortality and morbidity. The controversial subject in the present study is regarding the duration of symptoms. The duration of symptoms had no effect on mortality nor morbidity in our study.
authors.affiliation: 1 Tepecik Education and Research Hospital, General Surgery Department, İzmir, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Unver
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Fırat
authors.forename: Ömer Vedat
authors.initials: ÖV
authors.lastname: Ünalp
authors.forename: Alper
authors.initials: A
authors.lastname: Uğuz
authors.forename: Tufan
authors.initials: T
authors.lastname: Gümüş
authors.forename: Taylan Özgür
authors.initials: TÖ
authors.lastname: Sezer
authors.forename: Şafak
authors.initials: Ş
authors.lastname: Öztürk
authors.forename: Tayfun
authors.initials: T
authors.lastname: Yoldaş
authors.forename: Sinan
authors.initials: S
authors.lastname: Ersin
authors.forename: Adem
authors.initials: A
authors.lastname: Güler
mesh_terms: D000367:Age Factors; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Peptic ulcer; Perforation; Prognostic