title: Coping strategies, hope, and treatment efficacy in pharmacoresistant inpatients with neurotic spectrum disorders.
abstract: BACKGROUND
  Approximately 30%-60% of patients with neurotic spectrum disorders remain symptomatic despite treatment. Identifying the predictors of good response to psychiatric and psychotherapeutic treatment may be useful for increasing treatment efficacy in neurotic patients. The objective of this study was to investigate the influence of hope, coping strategies, and dissociation on the treatment response of this group of patients.
  
  
  METHODS
  Pharmacoresistant patients, who underwent a 6-week psychotherapeutic program, were enrolled in the study. All patients completed the Clinical Global Impression (CGI) - both objective and subjective forms, Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI)-II at baseline and after 6 weeks. The COPE Inventory, the Adult Dispositional Hope Scale (ADHS), and the Dissociative Experiences Scale (DES) were completed at the start of the treatment.
  
  
  RESULTS
  Seventy-six patients completed the study. The mean scores for all scales measuring the severity of the disorders (BAI, BDI-II, subjective and objective CGI) significantly decreased during the treatment. Several subscores of the COPE Inventory, the overall score of ADHS, and the overall score of DES significantly correlated with the treatment outcome. Multiple regression was used to find out which factors were the most significant predictors of the therapeutic outcomes. The most important predictors of the treatment response were the overall levels of hope and dissociation.
  
  
  CONCLUSIONS
  According to our results, a group of patients with a primary neurotic disorder, who prefer the use of maladaptive coping strategies, feel hopelessness, and have tendencies to dissociate, showed poor response to treatment.
authors.affiliation: Department of Psychology, Faculty of Arts, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic ; Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Marie
authors.initials: M
authors.lastname: Ociskova
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Prasko
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Kamaradova
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Ales
authors.initials: A
authors.lastname: Grambal
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Kasalova
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Sigmundova
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Klara
authors.initials: K
authors.lastname: Latalova
authors.affiliation: Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic.
authors.forename: Kristyna
authors.initials: K
authors.lastname: Vrbova
keywords: coping strategy; dissociation; hope; neurotic spectrum disorders; treatment efficacy