title: Current structural biology of the heparin interactome.
abstract: Heparin is the best known therapeutically active carbohydrate. It can bind and regulate multiple functional proteins such as coagulation cofactors, chemokines, and growth factors. This versatility has led to the recently developed concept of the heparin interactome--a group of proteins that, as the name implies, interact with heparin. The heparin interactome is structurally and functionally diverse. Though natural ligands of this class of proteins may be any of the glycosaminoglycans however, their structural biology is generally studied using heparin as a model compound. NMR spectroscopy contributes significantly to structural investigations of the resultant complexes in solution. This review aims therefore at discussing the current status in structural biology of the molecular complexes formed between heparin and its protein partners through the current concept of the heparin interactome.
authors.affiliation: Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil. Electronic address: pominvh@bioqmed.ufrj.br.
authors.forename: Vitor H
authors.initials: VH
authors.lastname: Pomin
authors.affiliation: Glycosciences Laboratory, Imperial College, Department of Medicine, Burlington Danes Building, Du Cane Road, London W12 0NN, UK. Electronic address: b.mulloy@imperial.ac.uk.
authors.forename: Barbara
authors.initials: B
authors.lastname: Mulloy
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000737:chemistry / Q000378:metabolism; D049109:Cell Proliferation; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000378:metabolism; D018925:Chemokines / Q000737:chemistry / Q000378:metabolism; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism; D006493:Heparin / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D066329:Protein Aggregates; D011485:Protein Binding; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001779:Blood Coagulation Factors; D057846:Cell-Penetrating Peptides; D018925:Chemokines; D016207:Cytokines; D007155:Immunologic Factors; D008024:Ligands; D066329:Protein Aggregates; D017468:Receptors, Fibroblast Growth Factor; D006493:Heparin