title: Clinical Phenotype Classifications Based on Static Varus Alignment and Varus Thrust in Japanese Patients With Medial Knee Osteoarthritis.
abstract: OBJECTIVE
  To investigate the association between knee pain during gait and 4 clinical phenotypes based on static varus alignment and varus thrust in patients with medial knee osteoarthritis (OA).
  
  
  METHODS
  Patients in an orthopedic clinic (n = 266) diagnosed as having knee OA (Kellgren/Lawrence [K/L] grade ≥1) were divided into 4 phenotype groups according to the presence or absence of static varus alignment and varus thrust (dynamic varus): no varus (n = 173), dynamic varus (n = 17), static varus (n = 50), and static varus + dynamic varus (n = 26). The knee range of motion, spatiotemporal gait parameters, visual analog scale scores for knee pain, and scores on the Japanese Knee Osteoarthritis Measure were used to assess clinical outcomes. Multiple logistic regression analyses identified the relationship between knee pain during gait and the 4 phenotypes, adjusted for possible risk factors, including age, sex, body mass index, K/L grade, and gait velocity.
  
  
  RESULTS
  Multiple logistic regression analysis showed that varus thrust without varus alignment was associated with knee pain during gait (odds ratio [OR] 3.30, 95% confidence interval [95% CI] 1.08-12.4), and that varus thrust combined with varus alignment was strongly associated with knee pain during gait (OR 17.1, 95% CI 3.19-320.0). Sensitivity analyses applying alternative cutoff values for defining static varus alignment showed comparable results.
  
  
  CONCLUSIONS
  Varus thrust with or without static varus alignment was associated with the occurrence of knee pain during gait. Tailored interventions based on individual malalignment phenotypes may improve clinical outcomes in patients with knee OA.
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Iijima
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukutani
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Aoyama
authors.affiliation: Kio University, Nara, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Kio University, Nara, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uritani
authors.affiliation: Nozomi Orthopaedic Clinic, Hiroshima, Japan.
authors.forename: Eishi
authors.initials: E
authors.lastname: Kaneda
authors.affiliation: Ota Orthopaedic Clinic, Kyoto, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ota
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kuroki
authors.affiliation: Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsuda
mesh_terms: D000368:Aged; D017760:Bone Malalignment / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D005260:Female; D005684:Gait / Q000502:physiology*; D006801:Humans; D007564:Japan; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D020370:Osteoarthritis, Knee / Q000145:classification / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010146:Pain; D010641:Phenotype; D011859:Radiography; D016059:Range of Motion, Articular; D012307:Risk Factors; D012720:Severity of Illness Index