title: Predictive value of neutrophil to lymphocyte ratio in first-time and recurrent idiopathic sudden sensorineural hearing loss.
abstract: OBJECTIVE
  To determine if the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with recurrent idiopathic sudden sensorineural hearing loss (ISSNHL) differ from those in healthy people and non-recurrent ISSNHL patients.
  
  
  METHODS
  A retrospective review of 16 patients with recurrent ISSNHL was performed with strict exclusion criteria. Independent variables were NLR and PLR, which yielded four groups (control, non-recurrent, recurrent-first attack, and recurrent-second attack groups).
  
  
  RESULTS
  Compared with the control group, non-recurrent and recurrent attack groups showed significantly higher NLR values (p<0.001, respectively). The NLR (odds ratio [OR] 2.178, 95% confidence interval [CI] 1.587-2.988; p<0.001) and PLR (OR, 1.013, 95% CI, 1.006-1.020; p<0.001) were found to be independent risk factors only between the control and recurrent-first attack groups.
  
  
  CONCLUSIONS
  Evidence of increased NLR and PLR is shown in recurrent ISSNHL and non-recurrent ISSNHL, and these increased levels are shown in the second attack of recurrent ISSNHL. Clinicians are advised to monitor the NLR and PLR at the clinic to predict recurrent ISSNHL even after hearing is restored.
authors.affiliation: Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Seo
authors.affiliation: Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Yoon Ah
authors.initials: YA
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Jeong Pyo
authors.initials: JP
authors.lastname: Bong
authors.affiliation: Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
authors.forename: Dong-Joon
authors.initials: DJ
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address: okas2000@hanmail.net.
authors.forename: Sang Yoo
authors.initials: SY
authors.lastname: Park
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology*; D015331:Cohort Studies; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood*; D003639:Hearing Loss, Sudden / Q000097:blood*; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies
keywords: Idiopathic sudden sensorineural hearing loss; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Recurrence