title: Synthesis and Biological Evaluation of Quinazoline Derivatives as Potential Anticancer Agents (II).
abstract: Under the guidance of our previous work, we synthesized 21 new structures of quinazolines (3a~3u) and evaluated their in vitro anticancer activity against A549, HCT116 and MCF-7 cell lines using the MTT method. Most compounds showed good to excellent anticancer activity. In particular, 3o (regarded as erlotinib analogues) has marked anticancer activity against A549, HCT116 and MCF-7 cell lines (IC50s: 4.26, 3.92 and 0.14 μM, respectively) as compared with the standard anticancer drug gefitinib (IC50s: 17.9, 21.55 and 20.68 μM, respectively), and which can be regarded as the best candidate for development of anticancer drugs.
authors.forename: Jianping
authors.initials: J
authors.lastname: Yong
authors.affiliation: Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, China, Fuzhou, 350002, China. czlu@fjirsm.ac.cn.
authors.forename: Canzhong
authors.initials: C
authors.lastname: Lu
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines