title: [The level of interleukin-101, tumor a necrosis factor and their dissolving receptors in women with ischemic heart disease comorbide with osteoporosis].
abstract: The sampling consisted of 98 women (average age 71.2 ± 8.6 years) with ischemic heart disease. The combination of ischemic heart disease and severe osteoporosis was diagnosed in 48 out of them. All female patients were analyzed for level of IL-1β, TNF-α and their soluble receptors in blood serum. The technique of immune enzyme analysis was applied. It was revealed that in women with associated pathology the level of TNF-α was higher and concentration of soluble receptors reliably lower than in women with isolated ischemic heart disease. It was established that direct correlation relationship exists between occurrence of bone fractures, coronary atherosclerosis and level of TNF-α. The occurrence of bone fractures was inversely correlated with level of soluble receptors of TNF (γ = 0.3; p = 0.0029), and occurrence of ischemic heart disease with soluble receptors of IL-1.
authors.forename: S Yu
authors.initials: SY
authors.lastname: Tsarenok
authors.forename: V V
authors.initials: VV
authors.lastname: Gorbunov
authors.forename: P P
authors.initials: PP
authors.lastname: Tereshkov
mesh_terms: D000368:Aged; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000473:pathology; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D017202:Myocardial Ischemia / Q000097:blood* / Q000473:pathology; D010024:Osteoporosis / Q000097:blood* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha