title: [On new screening biomarker to evaluate health state in personnel engaged into chemical weapons extinction].
abstract: The work was aimed to find new screeding parameters (biomarkers) for evaluation of health state of workers engaged into enterprises with hazardous work conditions, as exemplified by "Maradykovskyi" object of chemical weapons extinction. Analysis of 27 serum cytokines was conducted in donors and the object personnel with various work conditions. Findings are statistically significant increase of serum eotaxin in the personnel of "dirty" zone, who are regularly exposed to toxic agents in individual filter protective means over the working day. For screening detection of health disorders in the object personnel, the authors suggested new complex biomarker--ratio Eotaxin* IFNγ/TNFα that demonstrates 67.9% sensitivity and 87.5% specificity in differentiating the "dirty" zone personnel and other staffers.
authors.forename: N G
authors.initials: NG
authors.lastname: Voitenko
authors.forename: V V
authors.initials: VV
authors.lastname: Garniuk
authors.forename: D S
authors.initials: DS
authors.lastname: Prokofieva
authors.forename: N V
authors.initials: NV
authors.lastname: Gontcharov
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002618:Chemical Warfare; D002619:Chemical Warfare Agents / Q000009:adverse effects / Q000032:analysis; D003666:Decontamination / Q000379:methods; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects; D012426:Russia; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D002619:Chemical Warfare Agents; D020382:Interleukin-18; D014409:Tumor Necrosis Factor-alpha