title: Impaired skin barrier function in mice with colon carcinoma induced by azoxymethane and dextran sodium sulfate.
abstract: We have previously reported that impaired skin barrier function was induced by small intestinal injury in mice. Therefore, we postulated that other intestinal diseases might also influence skin barrier function. In this study, we evaluated the skin barrier function of hairless mice with colon carcinoma that was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). In mice treated with these drugs, we observed elevated transepidermal water loss and reduced skin hydration levels, compared to those in the control mice. In addition, plasma nitrogen di/trioxide (NO2(-)/NO3(-)) levels were significantly elevated, and expression of type I collagen was significantly reduced in the treated mice, compared to those in control. These results suggest that impaired skin barrier function occurs in mice when colon carcinoma is present.
authors.affiliation: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hiramoto
authors.forename: Mayu
authors.initials: M
authors.lastname: Koyama
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ooi
mesh_terms: D000818:Animals; D001397:Azoxymethane; D002463:Cell Membrane Permeability; D024042:Collagen Type I / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000097:blood / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D016264:Dextran Sulfate; D008297:Male; D008812:Mice, Hairless; D009585:Nitrogen Dioxide / Q000097:blood; D009589:Nitrogen Oxides / Q000097:blood; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D014867:Water / Q000378:metabolism
chemical_list: D024042:Collagen Type I; D009589:Nitrogen Oxides; D014867:Water; C031701:nitrogen trioxide; D016264:Dextran Sulfate; D001397:Azoxymethane; D009585:Nitrogen Dioxide