title: [Preclinical study of immunocorrection action of the sum of active substances of Coluria geoides (Pall.) Ledeb. (Rosaceae)].
abstract: A preclinical study of the immunocorrection action of the sum of active substances isolated from ethereal-oil plants Coluria geoides (Pall.) Ledeb. (Rosaceae family) with respect to experimental immunodeficiency showed that preparations relieve symptoms of immunodeficiency caused by the administration of cyclophosphan: suppressed synthesis of anti-erythrocyte antibodies (agglutinine) and proliferative processes in the spleen. Under the influence of C. geoides preparations, the absolute numbers of cariocytes and antibody forming cells in spleen significantly increased (compared to the group of animals with experimental immunodeficiency) and in some cases reached the background level. The drugs studied produced a more pronounced stimulating effect on the synthesis of specific immunoglobulins and proliferation of antibody forming cells of spleen as compared to the effect of Echinacea tincture. Preparation C-2 (extract from underground organs and grass of C. geoides obtained by percolation method with 70% ethanol) is most promising for in-depth research and the development of new effective drugs with immunocorrecting properties.
authors.forename: S V
authors.initials: SV
authors.lastname: Dutova
authors.forename: M R
authors.initials: MR
authors.lastname: Karpova
authors.forename: M A
authors.initials: MA
authors.lastname: Myadelets
authors.forename: N V
authors.initials: NV
authors.lastname: Myasnaya
authors.forename: E Yu
authors.initials: EY
authors.lastname: Sherstoboev
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D027824:Rosaceae / Q000737:chemistry*; D013154:Spleen / Q000276:immunology* / Q000473:pathology
chemical_list: D007155:Immunologic Factors; D010936:Plant Extracts