title: A 12-month angiographic and optical coherence tomography follow-up after bioresorbable vascular scaffold implantation in patients with ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  The aim of the study was to evaluate the healing process at 12 months after ABSORB™ bioresorbable vascular scaffold (BVS) implantation in patients with ST-segment elevation myocardial infarction (STEMI).
  
  
  BACKGROUND
  There is currently no data on long-term BVS performance in the acute thrombotic setting. The underlying altered plaque pathomorphology may impact the neointima healing pattern, potentially making it different to that observed in stable coronary artery disease (CAD).
  
  
  METHODS
  We have performed an angiographic and optical coherence tomography (OCT) 12-month follow-up of 19 STEMI patients who were treated with a BVS implantation (23 scaffolds). An independent core laboratory performed a paired analysis of the corresponding frames at baseline and follow-up.
  
  
  RESULTS
  At 12 months, the OCT follow-up showed a decrease in the mean lumen area (8.29 ± 1.53 mm(2) vs. 6.82 ± 1.57 mm(2) , P < 0.001), but no significant change in the mean scaffold area (8.49 ± 1.53 mm(2) vs. 8.90 ± 1.51 mm(2) ). Significant decreases in malapposed strut ratio (4.9 ± 8.65% vs. 0.4 ± 1.55%, P < 0.001) and malapposition area (0.29 ± 0.60 mm(2) 0.08 ± 0.32 mm(2) , P = 0.002) were observed. A nonhomogenous proliferation of neointima was revealed with a symmetry index of 0.15 (0.08-0.27), a mean neointima thickness of 203 μm (183-249) and mean neointima area of 2.07 ± 0.51 mm(2) . The quantitative coronary angiography showed late lumen loss of 0.08 ± 0.23 mm and no significant change in the minimal lumen diameter (P = 0.11). There were no major adverse cardiovascular events (MACE), except for one nontarget vessel revascularization.
  
  
  CONCLUSIONS
  The OCT revealed a favorable healing pattern after BVS implantation in a STEMI population.
authors.affiliation: 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Kochman
authors.affiliation: 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Tomaniak
authors.affiliation: 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Kołtowski
authors.affiliation: Krakow Cardiovascular Research Institute, Krakow, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Jąkała
authors.affiliation: Krakow Cardiovascular Research Institute, Krakow, Poland.
authors.forename: Klaudia
authors.initials: K
authors.lastname: Proniewska
authors.affiliation: Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Legutko
authors.affiliation: Krakow Cardiovascular Research Institute, Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Roleder
authors.affiliation: 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Pietrasik
authors.affiliation: 1st Department of Cardiology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Rdzanek
authors.affiliation: Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Wacław
authors.initials: W
authors.lastname: Kochman
authors.affiliation: Department of Cardiology, Thorax Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Brugaletta
authors.affiliation: Department of Cardiology, Thorax Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Grzegorz L
authors.initials: GL
authors.lastname: Kaluza
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods*; D054855:Drug-Eluting Stents; D004562:Electrocardiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000628:therapy*; D015588:Observer Variation; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D011475:Prosthesis Failure; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014654:Vascular Patency / Q000502:physiology
keywords: ST-segment elevation myocardial infarction; bioresorbable vascular scaffold; long-term follow-up; neointima healing process; optical coherence tomography