title: Acute bone response to whole body vibration in healthy pre-pubertal boys.
abstract: The skeleton responds to mechanical stimulation. We wished to ascertain the magnitude and speed of the growing skeleton's response to a standardised form of mechanical stimulation, vibration. 36 prepubertal boys stood for 10 minutes in total on one of two vibrating platforms (high (>2 g) or low (<1 g) magnitude vibration) on either 1, 3 or 5 successive days (n=12 for each duration); 15 control subjects stood on an inactive platform. Blood samples were taken at intervals before and after vibration to measure bone formation (P1NP, osteocalcin) and resorption (CTx) markers as well as osteoprotegerin and sclerostin. There were no significant differences between platform and control groups in bone turnover markers immediately after vibration on days 1, 3 and 5. Combining platform groups, at day 8 P1NP increased by 25.1% (CI 12.3 to 38.0; paired t-test p=0.005) and bone resorption increased by 10.9% (CI 3.6 to 18.2; paired t-test p=0.009) compared to baseline. Osteocalcin, osteoprotogerin and sclerostin did not change significantly. The growing skeleton can respond quickly to vibration of either high or low magnitude. Further work is needed to determine the utility of such "stimulation-testing" in clinical practice.
authors.affiliation: Academic Unit of Child Health, Sheffield Children's Hospital, Western Bank, Sheffield, S10 2TH, UK.
authors.forename: R
authors.initials: R
authors.lastname: Harrison
authors.affiliation: Nutrition and Bone Health, Medical Research Council Human Nutrition Research Unit, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge CB1 9NL UK.
authors.forename: K
authors.initials: K
authors.lastname: Ward
authors.affiliation: School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK.
authors.forename: E
authors.initials: E
authors.lastname: Lee
authors.affiliation: Materials and Engineering Research Institute, Sheffield Hallam University, City Campus, Howard Street, Sheffield S1 1WB, UK.
authors.forename: H
authors.initials: H
authors.lastname: Razaghi
authors.affiliation: Materials and Engineering Research Institute, Sheffield Hallam University, City Campus, Howard Street, Sheffield S1 1WB, UK.
authors.forename: C
authors.initials: C
authors.lastname: Horne
authors.affiliation: Academic Unit of Child Health, Sheffield Children's Hospital, Western Bank, Sheffield, S10 2TH, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Bishop
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000886:Anthropometry; D001846:Bone Development / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis / Q000235:genetics; D001862:Bone Resorption / Q000503:physiopathology; D001842:Bone and Bones / Q000502:physiology*; D002648:Child; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000096:biosynthesis / Q000235:genetics; D010012:Osteogenesis / Q000502:physiology; D053244:Osteoprotegerin / Q000096:biosynthesis / Q000235:genetics; D010446:Peptide Fragments / Q000096:biosynthesis / Q000235:genetics; D010812:Physical Stimulation; D011347:Procollagen / Q000096:biosynthesis / Q000235:genetics; D014732:Vibration
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D053244:Osteoprotegerin; D010446:Peptide Fragments; D011347:Procollagen; C422903:SOST protein, human; C047202:procollagen Type I N-terminal peptide; D015675:Osteocalcin