title: A method for reducing the effects of motion contamination in arterial spin labeling magnetic resonance imaging.
abstract: Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N=57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.
authors.affiliation: Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Tanenbaum
authors.affiliation: Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.|Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Abraham Z
authors.initials: AZ
authors.lastname: Snyder
authors.affiliation: Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Brier
authors.affiliation: Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.|Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Beau M
authors.initials: BM
authors.lastname: Ances
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D002536:Cerebral Arteries / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D015331:Cohort Studies; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology / Q000098:blood supply; D006257:Head; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009038:Motion; D012016:Reference Values; D013113:Spin Labels
chemical_list: D013113:Spin Labels