title: Variations in Health-Related Quality of Life (HRQoL) and survival 1 year after stroke: five European population-based registers.
abstract: OBJECTIVE
  There were two main objectives: to describe and compare clinical outcomes and Patient-Reported Outcome Measures (PROMs) collected using standardised procedures across the European Registers of Stroke (EROS) at 3 and 12 months after stroke; and to examine the relationship between patients' Health-Related Quality of Life (HRQoL) at 3 months after stroke and survival up to 1 year across the 5 populations.
  
  
  METHODS
  Analysis of data from population-based stroke registers.
  
  
  METHODS
  European populations in Dijon (France); Kaunas (Lithuania); London (UK); Warsaw (Poland) and Sesto Fiorentino (Italy).
  
  
  METHODS
  Patients with ischaemic or intracerebral haemorrhage (ICH) stroke, registered between 2004 and 2006.
  
  
  METHODS
  (1) HRQoL, assessed by the physical component summary (PCS) and mental component summary (MCS) of the Short-Form Health Survey (SF-12), mapped into the EQ-5D to estimate responses on 5 dimensions (mobility, activity, pain, anxiety and depression, and self-care) and utility scores. (2) Mortality within 3 months and within 1 year of stroke.
  
  
  RESULTS
  Of 1848 patients, 325 were lost to follow-up and 500 died within a year of stroke. Significant differences in mortality, HRQoL and utility scores were found, and remained after adjustments. Kaunas had an increased risk of death; OR 2.34, 95% CI (1.32 to 4.14) at 3 months after stroke in Kaunas, compared with London. Sesto Fiorentino had the highest adjusted PCS: 43.54 (SD=0.96), and Dijon had the lowest adjusted
  38.67 (SD=0.67). There are strong associations between levels of the EQ-5D at 3 months and survival within the year. The trend across levels suggests a dose-response relationship.
  
  
  CONCLUSIONS
  The study demonstrated significant variations in survival, HRQoL and utilities across populations that could not be explained by stroke severity and sociodemographic factors. Strong associations between HRQoL at 3 months and survival to 1 year after stroke were identified.
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: Salma
authors.initials: S
authors.lastname: Ayis
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK Department of Public Health and Primary Care, Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Wellwood
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Rudd
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: McKevitt
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Parkin
authors.affiliation: Division of Health and Social Care Research, King's College London, London, UK NIHR Biomedical Research Centre at Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
authors.forename: Charles D A
authors.initials: CD
authors.lastname: Wolfe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000523:psychology; D003863:Depression / Q000523:psychology; D005060:Europe; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D010146:Pain / Q000523:psychology; D063868:Patient Outcome Assessment; D011788:Quality of Life / Q000523:psychology*; D012042:Registries; D020521:Stroke / Q000401:mortality* / Q000523:psychology