title: Visceral obesity, but not metabolic syndrome, is associated with the presence of post-thrombotic syndrome.
abstract: BACKGROUND
  The relationship between metabolic syndrome (MetS), and the development of post-thrombotic syndrome (PTS) is currently unknown.
  
  
  METHODS
  We enrolled 120 patients with a previous episode of deep venous thrombosis (DVT) diagnosed more than 2years apart from the enrollment. Presence of MetS was identified according to NCEP ATP III criteria and Villalta Score (VS) was used to establish the presence of PTS (VS≥5).
  
  
  RESULTS
  We identified 49 (40.8%) subjects with clinical diagnosed of PTS. Patients with or without PTS showed comparable age and temporal distance from DVT event. We observed higher BMI (p=0.005) and waist circumference (p=0.006) among subjects with VS≥5 as compared to patients without PTS. No differences between the two groups were found in terms of lipid profile, blood pressure, diabetes, hs-CRP level and ongoing medications. The prevalence of MetS was equally distributed among patients with or without PTS (20% vs 26% respectively, p=0.64). Among the individual components of MetS only the prevalence of visceral adiposity was significantly increased in subjects affected by PTS (OR 2.81, p=0.008). Moreover, a significant linear correlation was found between VS and waist circumference in the entire cohort (r=0,354, p<0.0001).
  
  
  CONCLUSIONS
  There is no evidence of association between MetS and PTS. However, the degree of visceral adiposity is strongly correlated with the presence and severity of post-thrombotic disease.
authors.affiliation: Department of Medicine, University of Padova, Italy; Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy. Electronic address: marcello.rattazzi@unipd.it.
authors.forename: M
authors.initials: M
authors.lastname: Rattazzi
authors.affiliation: Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Callegari
authors.affiliation: Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sponchiado
authors.affiliation: Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Galliazzo
authors.affiliation: Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Pagliara
authors.affiliation: Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Villalta
authors.affiliation: Department of Medicine, University of Padova, Italy; Medicina Interna I^, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pauletto
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000150:complications*; D054070:Postthrombotic Syndrome / Q000209:etiology*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000209:etiology*; D055105:Waist Circumference
keywords: metabolic syndrome; post-thrombotic syndrome; venous thromboembolism; visceral obesity