title: Predicting Pediatric Drug Disposition-Present and Future Directions of Pediatric Physiologically-Based Pharmacokinetics.
abstract: This mini-review examines the current state of pediatric physiologically-based pharmacokinetic (PBPK) modeling, including methodologies, approaches, and recent developments. Also discussed are United States regulations that have helped to shape the pediatric PBPK landscape and the ongoing urgent need for pediatric clinical studies. Finally, current pediatric PBPK software as well as the areas of focus for future studies will be reviewed.
authors.forename: Shogo John
authors.initials: SJ
authors.lastname: Miyagi
authors.affiliation: Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, USA. smiyagi@childrensnational.org.
authors.forename: Janel R
authors.initials: JR
authors.lastname: Long-Boyle
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D017277:Drug Approval; D054796:Drug Dosage Calculations; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D018570:Risk Assessment; D012984:Software; D014481:United States
chemical_list: D004364:Pharmaceutical Preparations