title: Do elevated plasma S100A12 levels predict atherosclerosis in peritoneal dialysis patients?
abstract: OBJECTIVE
  Atherosclerotic cardiovascular disease is one of the major causes of mortality and morbidity in peritoneal dialysis (PD) patients. S100A12 is an endogenous receptor ligand of advanced glycation end-products. It was shown to contribute to the development of atherosclerosis in animal models. The aim of this study was to evaluate the relationship between S100A12 levels and carotid atherosclerosis in PD patients.
  
  
  METHODS
  A cross-sectional study was performed in 56 PD patients and 20 control subjects. Plasma S100A12 levels were measured from all participants beside routine laboratory evaluation. All subjects underwent high-resolution B-mode ultrasonography to determine carotid intima media thickness (CIMT). S100A12 levels were compared between patient and control groups. Correlation analyses of S100A12 with other laboratory values and CIMT were also performed.
  
  
  RESULTS
  Plasma S100A12 levels were higher in PD patients compared with control subjects (129.5 ± 167.2 ng/mL vs. 48.5 ± 30.3 ng/mL, respectively, p < 0.001). In the patient group, CIMT was found to be positively correlated with age (r = 0.354; p = 0.007), CRP level (r = 0.269; p = 0.045), and S100A12 (r = 0.293; p = 0.028) level while it was found to be negatively correlated with hemoglobin concentration (r = -0.264; p = 0.049). In the linear regression analysis, the model, including CRP, S100A12, age, and Hgb, was found to be significant (F: 4.177, p: 0.005). When the parameters are analyzed age and S100A12 were found to be independent determinants of CIMT (β = 0.308, p = 0.018 and β = 0.248, p = 0.049, respectively).
  
  
  CONCLUSIONS
  This study suggests that an elevated plasma S100A12 level was closely associated with atherosclerosis. With aging elevated plasma S100A12 may show a powerful proatherogenic potential in patients undergoing PD.
authors.affiliation: a Nephrology Department , Diskapi Yildirim Beyazid Research and Training Hospital , Ankara , Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yayar
authors.forename: Baris
authors.initials: B
authors.lastname: Eser
authors.forename: Mehmet
authors.initials: M
authors.lastname: Buyukbakkal
authors.forename: Bulent
authors.initials: B
authors.lastname: Erdogan
authors.forename: Zafer
authors.initials: Z
authors.lastname: Ercan
authors.forename: Ozgur
authors.initials: O
authors.lastname: Merhametsiz
authors.forename: Ayhan
authors.initials: A
authors.lastname: Haspulat
authors.forename: Alattin
authors.initials: A
authors.lastname: Kali
authors.forename: Tolga
authors.initials: T
authors.lastname: Yildirim
authors.forename: Basol
authors.initials: B
authors.lastname: Canbakan
authors.forename: M Deniz
authors.initials: MD
authors.lastname: Ayli
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D000067616:S100A12 Protein / Q000097:blood*
chemical_list: D015415:Biomarkers; D000067616:S100A12 Protein
keywords: Atherosclerosis; S100A12; carotid intima media thickness; inflammation; peritoneal dialysis