title: Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures.
abstract: Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia, v.bashkatova@nphys.ru.
authors.forename: V G
authors.initials: VG
authors.lastname: Bashkatova
authors.forename: S K
authors.initials: SK
authors.lastname: Sudakov
authors.forename: H
authors.initials: H
authors.lastname: Prast
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D020195:Epilepsy, Reflex / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D007189:Indans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011922:Rats, Mutant Strains; D064529:Receptor, Metabotropic Glutamate 5 / Q000037:antagonists & inhibitors* / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: C095756:1-aminoindan-1,5-dicarboxylic acid; D018691:Excitatory Amino Acid Antagonists; C578937:Grm5 protein, rat; D007189:Indans; D009419:Nerve Tissue Proteins; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D009569:Nitric Oxide; C121465:6-methyl-2-(phenylethynyl)pyridine