title: [Effect of food thickener on disintegration and dissolution of magnesium oxide tablets].
abstract: It has been reported that magnesium oxide tablets are excreted in a non-disintegrated state in the stool of patients when the tablets are administered after being immersed in a food thickener. Therefore we examined whether immersion in a food thickener affects the pharmacological effect in patients taking magnesium oxide tablets, and whether immersion affects its disintegration and solubility. The mean dosage (1705 mg/d) was higher for patients who took tablets after immersion in a food thickener than for those who took non-immersed tablets (1380 mg/d). The disintegration time and dissolution rate of the immersed tablets were lower than those of non-immersed tablets in vitro. Furthermore, components that constitute the food thickener and differences in composition concentrations differentially affect the disintegration and solubility of magnesium oxide tablets. This suggests that commercially available food thickeners are likely to be associated with changes in the degradation of magnesium oxide tablets, and they therefore should be carefully used in certain clinical situations.
authors.affiliation: Department of Pharmacy, Hospital Bando.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tomita
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Goto
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tsubouchi
authors.forename: Rie
authors.initials: R
authors.lastname: Nakanishi
authors.forename: Chikako
authors.initials: C
authors.lastname: Kojima
authors.forename: Mihoko
authors.initials: M
authors.lastname: Yoneshima
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Katsuya
authors.initials: K
authors.lastname: Tanaka
authors.forename: Kenji
authors.initials: K
authors.lastname: Sumiya
authors.forename: Yukinao
authors.initials: Y
authors.lastname: Kohda
mesh_terms: D000863:Antacids; D065546:Drug Liberation; D005503:Food Additives / Q000009:adverse effects*; D018565:Food-Drug Interactions; D007101:Immersion; D054368:Laxatives; D008277:Magnesium Oxide / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000009:adverse effects*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D000863:Antacids; D005503:Food Additives; D054368:Laxatives; D011135:Polysaccharides, Bacterial; D013607:Tablets; D008277:Magnesium Oxide; C002563:xanthan gum