title: Jamestown Canyon Virus Disease in the United States-2000-2013.
abstract: Jamestown Canyon virus (JCV) is a mosquito-borne orthobunyavirus in the California serogroup that can cause an acute febrile illness, meningitis, or meningoencephalitis. We describe epidemiologic and clinical features for JCV disease cases occurring in the United States during 2000-2013. A case of JCV disease was defined as an acute illness in a person with laboratory evidence of a recent JCV infection. During 2000-2013, we identified 31 cases of JCV disease in residents of 13 states. The median age was 48 years (range, 10-69) and 21 (68%) were male. Eleven (35%) case patients had meningoencephalitis, 6 (19%) meningitis, 7 (23%) fever without neurologic involvement, and 7 (23%) had an unknown clinical syndrome. Fifteen (48%) were hospitalized and there were no deaths. Health-care providers and public health officials should consider JCV disease in the differential diagnoses of viral meningitis and encephalitis, obtain appropriate specimens for testing, and report cases to public health authorities.
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Pastula
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York.
authors.forename: Diep K
authors.initials: DK
authors.lastname: Hoang Johnson
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: White
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York.
authors.forename: Alan P
authors.initials: AP
authors.lastname: Dupuis
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York.
authors.forename: Marc
authors.initials: M
authors.lastname: Fischer
authors.affiliation: EIS Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia; Arboviral Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado; Wisconsin Department of Health Services, Madison, Wisconsin; New York State Department of Health and Wadsworth Center, Albany, New York estaples@cdc.gov.
authors.forename: J Erin
authors.initials: JE
authors.lastname: Staples
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D009033:Culicidae / Q000821:virology; D002141:Encephalitis Virus, California / Q000302:isolation & purification*; D004670:Encephalitis, California / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014481:United States / Q000453:epidemiology; D055815:Young Adult