title: DD Genotype of ACE I/D Polymorphism Might Confer Protection against Dental Caries in Polish Children.
abstract: The aim of the study was to examine the frequencies of the genotypes and alleles of ACE insertion/deletion (I/D) polymorphism and their association with dental caries in a sample of Polish children. The study subjects were 120 children with dental caries experience (cases) and 41 caries-free individuals (controls). The genotyping was performed using polymerase chain reaction. The genotype distributions of ACE I/D polymorphism were not statistically different between carious and control children. However, we found a borderline overrepresentation of the II + ID genotypes versus the DD genotype in the carious compared to the control group (69.2% and 51.2%, respectively, p = 0.057). Logistic regression analysis adjusted for age and sex revealed that I allele carriage was a significant predictor of dental caries susceptibility (OR = 2.14, 95% CI = 1.02-4.49, p = 0.041). In conclusion, the DD genotype of ACE I/D polymorphism might be protective against dental caries in Polish children.
authors.affiliation: Department of Hygiene and Epidemiology, Pomeranian Medical University, Szczecin, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Olszowski
authors.forename: Grażyna
authors.initials: G
authors.lastname: Adler
authors.forename: Joanna
authors.initials: J
authors.lastname: Janiszewska-Olszowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.forename: Dariusz
authors.initials: D
authors.lastname: Chlubek
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002675:Child, Preschool; D004245:DMF Index; D003731:Dental Caries / Q000235:genetics*; D003733:Dental Caries Susceptibility / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011044:Poland; D011110:Polymorphism, Genetic / Q000235:genetics*; D014094:Tooth, Deciduous / Q000473:pathology
chemical_list: D007703:Peptidyl-Dipeptidase A