title: [Polysuccinimide exhibited antitumor activity in the experiment].
abstract: Antitumor activity of the novel for oncology compound, such as polysuccinimide, against some of experimental tumor models (Lewis lung carcinoma, Acatol adenocarcinoma, Ca-755 adenocarcinoma) has been established. This drug induced 60-80% tumor growth inhibition of these murine solid tumor strains. Polysuccinimide is also effective (60%) against development of metastatic process in lung (Lewis lung carcinoma). Polysuccinimide causes no changes in pH level in tumor tissue (P-388 leukemia, Acatol adenocarcinoma). This agent may be recommended for further profound preclinical study.
authors.forename: L A
authors.initials: LA
authors.lastname: Ostrovskaya
authors.forename: D B
authors.initials: DB
authors.lastname: Korman
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeev
authors.forename: V A
authors.initials: VA
authors.lastname: Goldberg
authors.forename: M M
authors.initials: MM
authors.lastname: Fomina
authors.forename: N V
authors.initials: NV
authors.lastname: Bluhterova
authors.forename: V A
authors.initials: VA
authors.lastname: Rikova
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001224:Aspartic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D051379:Mice; D010455:Peptides / Q000008:administration & dosage* / Q000138:chemical synthesis
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; C025252:poly-DL-succinimide; D001224:Aspartic Acid