title: Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis.
abstract: OBJECTIVE
  To establish whether there is a relationship between serum magnesium (Mg) concentration and radiographic knee osteoarthritis (OA).
  
  
  METHODS
  There were 2855 subjects in this cross-sectional study. Serum Mg concentration was measured using the chemiluminescence method. Radiographic OA of the knee was defined as changes consistent with Kellgren-Lawrence (K-L) grade 2 on at least 1 side. Mg concentration was classified into 1 of 4 quartiles: ≤ 0.87, 0.88-0.91, 0.92-0.96, or ≥ 0.97 mmol/l. Multivariable logistic analysis was used to test the association between serum Mg and radiographic knee OA after adjustment for potentially confounding factors. The OR with 95% CI for the association between radiographic knee OA and serum Mg concentration were calculated for each quartile. The quartile with the lowest value was regarded as the reference category.
  
  
  RESULTS
  Significant association between serum Mg concentration and radiographic knee OA was observed in the model after adjustment for age, sex, and body mass index, as well as in the multivariable model. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth serum Mg concentration quartiles were 0.90 (95% CI 0.71-1.13), 0.92 (95% CI 0.73-1.16), and 0.72 (95% CI 0.57-0.92), respectively, compared with the lowest (first) quartile. A clear trend (p for trend was 0.01) was observed. The relative odds of radiographic knee OA was decreased by 0.72 times in the fourth serum Mg quartile compared with the lowest quartile.
  
  
  CONCLUSIONS
  Serum Mg concentration may have an inverse relationship with radiographic OA of the knee.
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Tuo
authors.initials: T
authors.lastname: Yang
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Fang-Jie
authors.initials: FJ
authors.lastname: Zhang
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Ding
authors.initials: D
authors.lastname: Pan
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Yong-Bing
authors.initials: YB
authors.lastname: Xiao
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University.
authors.forename: Tu-Bao
authors.initials: TB
authors.lastname: Yang
authors.affiliation: From the Department of Orthopedics, Xiangya Hospital, and Department of Epidemiology and Health Statistics, School of Public Health Central South University, Central South University, Changsha, Hunan Province, China.C. Zeng, MD, Department of Orthopedics, Xiangya Hospital, Central South University; J. Wei, MD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; H. Li, MD; T. Yang, MD; F.J. Zhang, PhD; D. Pan, PhD; Y.B. Xiao, PhD, Department of Orthopedics, Xiangya Hospital, Central South University; T.B. Yang, PhD, Department of Epidemiology and Health Statistics, School of Public Health, Central South University; G.H. Lei, MD, PhD, Department of Orthopedics, Xiangya Hospital, Central South University. lgh9640@sina.cn.
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Lei
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography; D012307:Risk Factors
chemical_list: D008274:Magnesium
keywords: CROSS-SECTIONAL STUDY; KNEE OSTEOARTHRITIS; SERUM MAGNESIUM