title: Low cytotoxicity and clastogenicity of some polymeric aminophosphonate derivatives.
abstract: Poly(oxyethylene aminophosphonate)s synthesized on the basis of biodegradable poly(phosphorester)s and Schiff bases were testedin vitrofor antitumor activity against a panel of six human epithelial cancer cell lines, for cytotoxicity to mouse fibroblast cells andin vivofor clastogenicity and antiproliferative effects. The polymers showed lower cytotoxicity, bothin vivoandin vitroand lower clastogenicityin vivothan the corresponding low-molecular aminophosphonates. The biological activities of the tested polymers correlate with their lowin vitroantitumor activity.
authors.affiliation: Bulgarian Academy of Sciences, Institute of Experimental Morphology, Pathology and Anthropology with Museum , Sofia , Bulgaria.
authors.forename: Anton
authors.initials: A
authors.lastname: Kril
authors.affiliation: Bulgarian Academy of Sciences, Institute of Biodiversity and Ecosystems Research , Sofia , Bulgaria.
authors.forename: Margarita
authors.initials: M
authors.lastname: Topashka-Ancheva
authors.affiliation: Bulgarian Academy of Sciences, Institute of Experimental Morphology, Pathology and Anthropology with Museum , Sofia , Bulgaria.
authors.forename: Any
authors.initials: A
authors.lastname: Georgieva
authors.affiliation: Bulgarian Academy of Sciences, Institute of Experimental Morphology, Pathology and Anthropology with Museum , Sofia , Bulgaria.
authors.forename: Ivan
authors.initials: I
authors.lastname: Iliev
authors.affiliation: Bulgarian Academy of Sciences, Institute of Biodiversity and Ecosystems Research , Sofia , Bulgaria.
authors.forename: Tsvetelina
authors.initials: T
authors.lastname: Gerasimova
authors.affiliation: Bulgarian Academy of Sciences, Institute of Polymers , Sofia , Bulgaria.
authors.forename: Ivanka
authors.initials: I
authors.lastname: Kraicheva
authors.affiliation: Bulgarian Academy of Sciences, Institute of Polymers , Sofia , Bulgaria.
authors.forename: Ivelina
authors.initials: I
authors.lastname: Tsacheva
authors.affiliation: Bulgarian Academy of Sciences, Institute of Polymers , Sofia , Bulgaria.
authors.forename: Anita
authors.initials: A
authors.lastname: Bogomilova
authors.affiliation: Bulgarian Academy of Sciences, Institute of Polymers , Sofia , Bulgaria.
authors.forename: Elitsa
authors.initials: E
authors.lastname: Vodenicharova
authors.affiliation: Bulgarian Academy of Sciences, Institute of Polymers , Sofia , Bulgaria.
authors.forename: Kolio
authors.initials: K
authors.lastname: Troev
keywords: cell lines; human epithelial cancer; poly(aminophosphonate)s; safety testing