title: Antimutagenic and anticancer activity of Al Madinah Alhasawy mint (Mentha longifolia) leaves extract.
abstract: Mentha is one of the genera of Lamiaceae family. The aim of the present study was to evaluate the antimutagenic and anticancer activity of the water and methanolic extract of Alhasawy mint (Mentha longifolia), that grown in Madina Province, western region, Saudi Arabia using three different bioassays namely; Brine shrimp bioassay, Ames mutagenicity bioassay using 3 Hist-Salmonella typhimurium strains of different mutations (TA98, TA97 and TA100) and 2 reference mutagenic drugs nitrosopiperidine (NP) and 2-amino-3-methylimidazo-quinolidine (IQ) and Mammalian cell lines bioassays using 2 different cell lines HepG2 and Vero cell lines. The plant extract showed an efficient antimutagenic activity against the studied bioassays in a directly proportional effect with concentration.
authors.forename: Khalil
authors.initials: K
authors.lastname: Al-Ali
authors.forename: Mohamad
authors.initials: M
authors.lastname: Abdelrazik
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Alghaithy
authors.forename: Atef
authors.initials: A
authors.lastname: Diab
authors.forename: Hesham
authors.initials: H
authors.lastname: El-Beshbishy
authors.forename: Hussam
authors.initials: H
authors.lastname: Baghdadi
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects / Q000196:embryology; D001681:Biological Assay; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D007814:Larva / Q000187:drug effects; D027541:Mentha / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012997:Solvents / Q000737:chemistry; D014709:Vero Cells; D014867:Water / Q000737:chemistry
chemical_list: D016587:Antimutagenic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D000432:Methanol