title: Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.
abstract: Inflammatory bowel diseases (IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis. These idiopathic diseases have environmental, genetic, immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type (Th) 1 and Th2 immune responses, other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin, microRNAs, and serum proinflammatory cytokines. An efficient strategy for IBD therapy is represented by the combination of IL-17A and IL-17F in acute IL-17A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17F knockout, DSS-induced colitis have been observed. Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused review in order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation.
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Cristina-Sorina
authors.initials: CS
authors.lastname: Cătană
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan Neagoe
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Vasile
authors.initials: V
authors.lastname: Cozma
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Magdaş
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Flaviu
authors.initials: F
authors.lastname: Tăbăran
authors.affiliation: Cristina-Sorina Cătană, Department of Medical Biochemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
authors.forename: Dan Lucian
authors.initials: DL
authors.lastname: Dumitraşcu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism*; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D053759:Interleukin-23 / Q000276:immunology / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000276:immunology; D010641:Phenotype; D011110:Polymorphism, Genetic; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism*
chemical_list: D005819:Genetic Markers; D018836:Inflammation Mediators; D020381:Interleukin-17; D053759:Interleukin-23
keywords: Crohn’s disease; Cytokines; Inflammatory bowel disease; Ulcerative colitis