title: Defining treatment response and symptom remission for anxiety disorders in pediatric autism spectrum disorders using the Pediatric Anxiety Rating Scale.
abstract: This study examined optimal guidelines to assess treatment response and remission for anxiety in youth with autism spectrum disorders (ASD) using the Pediatric Anxiety Rating Scale (PARS). Data was collected for 108 children aged 7-16 years with comorbid anxiety and ASD before and after receiving cognitive behavior therapy. Optimal cut-offs on the PARS were assessed using signal detection analyses using receiver operating characteristic methods. Maximum agreement with response criteria was achieved at 15 % reduction in symptoms on the PARS. Maximum agreement with remission criteria was achieved at 40 % reduction in symptoms, or at a score of 10 or below at post-treatment. Results have implications for standardizing criteria used in research trials and clinical practice.
authors.affiliation: Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA. cjohnco@health.usf.edu.|Rothman Center for Pediatric Neuropsychiatry, Child Development and Rehabilitation Center, 880 6th Street South Suite 460, Box 7523, St. Petersburg, FL, 33701, USA. cjohnco@health.usf.edu.
authors.forename: Carly J
authors.identifier: http://orcid.org/0000-0002-2212-507X
authors.initials: CJ
authors.lastname: Johnco
authors.affiliation: Department of Psychology, University of South Florida, Tampa, FL, USA.
authors.forename: Alessandro S
authors.initials: AS
authors.lastname: De Nadai
authors.affiliation: Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA.|Department of Psychology, University of South Florida, Tampa, FL, USA.|Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.
authors.forename: Adam B
authors.initials: AB
authors.lastname: Lewin
authors.affiliation: Department of Psychology, University of Miami, Miami, FL, USA.
authors.forename: Jill
authors.initials: J
authors.lastname: Ehrenreich-May
authors.affiliation: Division of Child Psychiatry, University of California, Los Angeles, CA, USA.|Division of Psychological Studies in Education, University of California, Los Angeles, CA, USA.
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Wood
authors.affiliation: Department of Pediatrics, University of South Florida, St. Petersburg, FL, USA.|Department of Psychology, University of South Florida, Tampa, FL, USA.|Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL, USA.|Department of Health Policy and Management, University of South Florida, Tampa, FL, USA.|Rogers Behavioral Health - Tampa Bay, Tampa, FL, USA.|All Children's Hospital - Johns Hopkins Medicine, St. Petersburg, FL, USA.
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000150:complications / Q000628:therapy*; D000067877:Autism Spectrum Disorder / Q000150:complications*; D002648:Child; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D008297:Male
keywords: Autism; Children; Measurement; Pediatric Anxiety Rating Scale; Treatment