title: Positive pressure therapy in patients with cardiac arrhythmias and obstructive sleep apnea.
abstract: BACKGROUND
  Positive pressure therapy (CPAP) in patients with cardiac arrhythmias and obstructive sleep apnea (OSAS) may have favorable effects by correcting intermittent hypoxemia and sympathetic activation.
  
  
  OBJECTIVE
  To assess the effect of CPAP added to pharmacological treatment in the rate control and prevention of arrhythmias recurrence in patients with OSA.
  
  
  METHODS
  Prospective, interventional study study which included patients diagnosed with OSAS (cardiorespiratorypolygraphy, AHI>5/hour), and arrhythmias (ECG, Holter ECG), divided in two groups: group A (pharmacological therapy only) and group B (pharmacological therapy and CPAP). The patients were evaluated at enrollment (T0), at 3 and 6 months (T3 and T6) regarding the type, severity and recurrence of cardiac arrhythmias.
  
  
  RESULTS
  36 patients (31 men), mean age: 63.2 ± 12 years were enroled. In group A: 7 patients with ventricular extrasystoles, 8 with permanent atrial fibrillation, 1 patient with atrial flutter and 2 patients with paroxystic supraventricular tachycardia. In group B: 8 patients with ventricular extrasystoles, 5 with permanent atrial fibrillation, 2 patients with recurrent episodes of atrial fibrillation and 3 with paroxystic supraventricular tachycardia. A positive correlation (r: 0.74, p < 0.001) between Oxygen Desaturation Index and AHI was found. At T6, 12 patients from group B, and 18 from group A were evaluated. In group B, the mean heart rate in patients with atrial fibrillation was 69/min., lower than in group A (82/min.), no cases with recurrent atrial fibrillation were found, and more patients with class II Lown ventricular extrasystoles passed in class I Lown, compared to group A. In group B, heart rate statistically correlated with AHI (r: 0.53, p < 0.005).
  
  
  CONCLUSIONS
  In patients with OSAS, adding CPAP to pharmacological therapy has favorable effects on preventing recurrences, heart rate control in patients with atrial fibrillation and in reducing frequency and/or severity of ventricular extrasystoles.
authors.forename: Giorgiana Nicoleta
authors.initials: GN
authors.lastname: Dediu
authors.forename: Stefan
authors.initials: S
authors.lastname: Dumitrache-Rujinski
authors.forename: Rizvan
authors.initials: R
authors.lastname: Lungu
authors.forename: Sabina
authors.initials: S
authors.lastname: Frunză
authors.forename: Camelia
authors.initials: C
authors.lastname: Diaconu
authors.forename: Daniela
authors.initials: D
authors.lastname: Bartoş
authors.forename: Miron Alexandru
authors.initials: MA
authors.lastname: Bogdan
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000188:drug therapy / Q000517:prevention & control*; D015992:Body Mass Index; D045422:Continuous Positive Airway Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000209:etiology / Q000628:therapy*; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents