title: Highly sensitive turn-on biosensors by regulating fluorescent dye assembly on liposome surfaces.
abstract: We developed a new self-signaling sensory system built on phospholipid liposomes having H-aggregated R6G dyes on their surface. Selective molecular recognition of a target by the phospholipid displaces R6G from the liposome surface to turn on fluorescence signal. Selective and sensitive detection of neomycin down to 2.3 nM is demonstrated.
authors.affiliation: Macromolecular Sci. and Eng., University of Michigan, USA.
authors.forename: Sungbaek
authors.initials: S
authors.lastname: Seo
authors.forename: Min Sang
authors.initials: MS
authors.lastname: Kwon
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Phillips
authors.forename: Deokwon
authors.initials: D
authors.lastname: Seo
authors.forename: Jinsang
authors.initials: J
authors.lastname: Kim
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D057230:Limit of Detection; D008081:Liposomes / Q000737:chemistry*; D009355:Neomycin / Q000032:analysis; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000737:chemistry; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry; D053279:Polyynes / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013499:Surface Properties
chemical_list: D005456:Fluorescent Dyes; D008081:Liposomes; D019269:Phosphatidylinositol 4,5-Diphosphate; D000078789:Polyacetylene Polymer; D011108:Polymers; D012235:Rhodamines; C026188:rhodamine 6G; D053279:Polyynes; C082361:polydiacetylene; D009355:Neomycin