title: Tumour characteristics and survival in familial breast cancer prospectively diagnosed by annual mammography.
abstract: Women from breast cancer families without a demonstrable BRCA1/2 mutation were subjected to annual mammography from age 30 years onwards. One-hundred and ninety-eight patients were diagnosed prospectively with invasive breast cancer and followed for a total of 1513 years. Overall 10-year survival was 88 %. Together with our previous report that women in such kindreds had about twice the population risk of breast cancer, the combined conclusion was that the overall chances of developing breast cancer causing death within 10 years before 50 years of age was 1 % or less when subjected to annual mammography and current treatment. These are empirical prospective observations which may be used for genetic counselling. The majority (160/194 = 84 %) of patients had ER+ and/or low grade tumours with 92 % 10-year survival. One minor group of the patients had ER- tumours, another small group had high grade tumours with nodal spread, both groups were associated with worse prognosis, but the two groups were not mutually associated.
authors.affiliation: Research Group Inherited Cancer, Oslo University Hospital, Oslo, Norway. Moller.pal@gmail.com.
authors.forename: Pål
authors.initials: P
authors.lastname: Møller
authors.affiliation: Department of Mathematics, University of Oslo, Blindern, Oslo, Norway.
authors.forename: Kukatharmini
authors.initials: K
authors.lastname: Tharmaratnam
authors.affiliation: Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.|Institute of Cancer Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: Howell
authors.affiliation: Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.
authors.forename: Paula
authors.initials: P
authors.lastname: Stavrinos
authors.affiliation: Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.
authors.forename: Sarah
authors.initials: S
authors.lastname: Sampson
authors.affiliation: Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.|Institute of Human Development and Central Manchester Foundation Trust, Manchester, M13 9WL, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Wallace
authors.affiliation: Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.|Institute of Population Health, University of Manchester, Oxford Road, Manchester, M13 9PT, United Kingdom.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Maxwell
authors.affiliation: Department of Breast and Endocrine Surgery, Norwegian University of Science and Technology, Trondheim, Norway.|Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Anne Irene
authors.initials: AI
authors.lastname: Hagen
authors.affiliation: Nightingale and Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, United Kingdom.|Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.|Institute of Human Development and Central Manchester Foundation Trust, Manchester, M13 9WL, United Kingdom.
authors.forename: D Gareth
authors.initials: DG
authors.lastname: Evans
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000401:mortality; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis