title: Promising prognostic markers of preeclampsia: new avenues in waiting.
abstract: Preeclampsia is a pregnancy related condition identified by hypertension and either proteinuria or end-organ dysfunction after 20(th) week of gestation and complicates 2-8% pregnancies worldwide. Enigmatic pathophysiology and multi-system involvement hinder accurate identification and clinical management of patients. Inadequate trophoblast invasion and subsequent inflammatory response have been implicated in the onset of PE. In absence of effective treatment of preeclampsia except delivery, recent research has been focused on identification of specific and sensitive biomarkers for early prediction of PE. Several angiogenic, anti-angiogenic, inflammatory, biophysical (mean arterial pressure and uterine artery Doppler) biomarkers, alone and in combination, have been proposed for prediction but limited predictive values have hindered their use in clinical settings. Current review summarizes some of relatively new biomarkers such as corin, copeptin, microparticles and miRNA, the prognostic efficiency of which are either analyzed in associated disorders or recently discovered.
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.
authors.forename: Anshul
authors.initials: A
authors.lastname: Jadli
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.
authors.forename: Nitika
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Nowrosjee Wadia Maternity Hospital, Acharya Donde Marg, Lower Parel, Mumbai 400012, India.
authors.forename: Kaizad
authors.initials: K
authors.lastname: Damania
authors.affiliation: Nowrosjee Wadia Maternity Hospital, Acharya Donde Marg, Lower Parel, Mumbai 400012, India.
authors.forename: Purnima
authors.initials: P
authors.lastname: Satoskar
authors.affiliation: Nowrosjee Wadia Maternity Hospital, Acharya Donde Marg, Lower Parel, Mumbai 400012, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Bansal
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.
authors.forename: Kanjaksha
authors.initials: K
authors.lastname: Ghosh
authors.affiliation: National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India. Electronic address: shrimatishetty@yahoo.com.
authors.forename: Shrimati
authors.initials: S
authors.lastname: Shetty
mesh_terms: D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000401:mortality / Q000503:physiopathology*; D011247:Pregnancy; D011379:Prognosis
keywords: Biomarkers; Copeptin; Corin; MicroRNA; Microparticles; Preeclampsia