title: Hepatitis B virus, hepatitis C virus, and kidney transplant acute rejection and survival.
abstract: The effect of hepatitis Bs-antigen (AgHBs) and anti-hepatitis C virus (HCV) positivity on renal transplant outcomes is still controversial. Some studies describe higher rates of acute rejection and allograft loss, and greater mortality in transplant recipients with hepatitis. We retrospectively evaluated data from 2284 allograft recipients who underwent transplantation at our hospital between July 1980 and December 2012. Statistical analysis was made using chi-square and Student t tests, Kaplan-Meier curves, and survival analysis. We identified 62 AgHBs+ patients, 99 anti-HCV+ patients, and 14 AgHBs+/anti-HCV+ patients; 2109 patients had "no hepatitis." Mean follow-up time was 7.93 years. No statistical differences were identified on allograft acute rejection rate or patient survival between groups. AgHBs+ patients had, however, an inferior allograft survival, with statistical significance. According to our study, hepatitis B has a harmful impact on allograft survival, although it does not compromise the patient survival.
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. Electronic address: vaniagrenha.uro@gmail.com.
authors.forename: V
authors.initials: V
authors.lastname: Grenha
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: B
authors.initials: B
authors.lastname: Parada
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Ferreira
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Figueiredo
authors.affiliation: Serviço de Nefrologia, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, Coimbra, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Macário
authors.affiliation: Serviço de Nefrologia, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, Coimbra, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Alves
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: H
authors.initials: H
authors.lastname: Coelho
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Sepúlveda
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: M J
authors.initials: MJ
authors.lastname: Freire
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Retroz
authors.affiliation: Serviço de Urologia e Transplantação Renal, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Mota
mesh_terms: D000208:Acute Disease; D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology* / Q000401:mortality; D006085:Graft Survival; D016174:Hepacivirus / Q000276:immunology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D006514:Hepatitis B Surface Antigens