title: Mesoporous calcium phosphate bionanomaterials with controlled morphology by an energy-efficient microwave method.
abstract: Calcium phosphate nanomaterials with controllable morphology and mesostructure were synthesized via a rapid and energy efficient microwave method. An increase in aspect ratio from nanoplates to nanorods was achieved by increasing the solvent chain length, accompanied by a subsequent about 23% increase in surface area and porosity. Control of mesoporosity was also achieved by varying the synthesis time and quantity of H2 O in the reaction solvent. Comparative studies were carried out using conventional heating (CON) and room temperature co-precipitation (RT) methods. It was found that microwave synthesis produces nanomaterials with about 50% higher yields, 7.5/1.7 times higher surface area and 3/5 times higher pore volume than RT/CON materials respectively, as well as having a lower distribution of particle size/shape (lower standard deviation values of their dimensions). Furthermore, in vitro protein loading tests of microwave synthesized mesoporous calcium phosphate materials showed an enhanced loading efficiency of bovine serum albumin (3-7 times), as compared with non-mesostructured products from room temperature precipitation, in accordance with their larger surface area and porosity.
authors.affiliation: Department of Chemical Engineering, UCL, London, WC1E 7JE, United Kingdom.
authors.forename: Philip James Thomas
authors.initials: PJ
authors.lastname: Reardon
authors.affiliation: Department of Mechanical Engineering, UCL, London, WC1E 7JE, United Kingdom.
authors.forename: Jie
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Chemical Engineering, UCL, London, WC1E 7JE, United Kingdom.
authors.forename: Junwang
authors.initials: J
authors.lastname: Tang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D008872:Microwaves; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D012710:Serum Albumin, Bovine; C020243:calcium phosphate
keywords: calcium phosphate; mesoporous; microwave synthesis; morphology control; nanobiomaterials