title: Germinoma with an extensive rhabdoid cell component centered at the corpus callosum.
abstract: Intracranial germinomas comprise 0.5-2.0 % of all central nervous system (CNS) tumors and 50-60 % of CNS germ cell tumors. They most frequently originate in the pineal gland and the suprasellar region. The corpus callosum is an extremely uncommon location for germinoma formation. Herein, we report about a 20-year-old man with a germinoma centered at the corpus callosum and that extended to both cerebral hemispheres. In addition to its location, this case is unique in that the amount of tumor cells with rhabdoid morphology exceeded that of tumor cells with typical morphology. The rhabdoid cell component showed an immunophenotype compatible with germinoma. While the presence of rhabdoid cells is generally regarded as a sign of aggressive behavior, the patient has been doing well for at least 4 years since undergoing radiation therapy and chemotherapy. The cellular composition of germinoma might not critically affect prognosis with adequate treatment.
authors.affiliation: Department of Pathology, Shizuoka Saiseikai General Hospital, 1-1-1 Oshika, Suruga-ku, Shizuoka, 422-8021, Japan. stajima-tky@umin.ac.jp.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Pathology, Fujieda Municipal General Hospital, Shizuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koda
mesh_terms: D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D018237:Germinoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018335:Rhabdoid Tumor / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D055815:Young Adult
keywords: Cerebrum; Corpus callosum; Germinoma; Rhabdoid