title: Hepatic encephalopathy in acute-on-chronic liver failure.
abstract: The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that inflammatory mediators may have a significant role in modulating the cerebral effect of ammonia. Multiple prospective and retrospective studies have shown that hepatic encephalopathy in ACLF patients is associated with higher mortality, especially in those with grade III-IV encephalopathy, similar to that of acute liver failure (ALF). Although significant cerebral edema detected by CT in ACLF patients appeared to be less common, specialized MRI imaging was able to detect cerebral edema even in low grade HE. Ammonia-focused therapy constitutes the basis of current therapy, as in the treatment of ALF. Emerging treatment strategies focusing on modulating the gut-liver-circulation-brain axis are discussed.
authors.affiliation: Department of Medicine, National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore. guan_huei_lee@nuhs.edu.sg.
authors.forename: Guan-Huei
authors.initials: GH
authors.lastname: Lee
mesh_terms: D065290:Acute-On-Chronic Liver Failure / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D014943:Global Health; D006501:Hepatic Encephalopathy / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D008279:Magnetic Resonance Imaging; D015996:Survival Rate / Q000639:trends
keywords: Acute-on-chronic liver failure; Brain imaging; Cerebral edema; Hepatic encephalopathy