title: Few-layer bismuth selenides exfoliated by hemin inhibit amyloid-β1-42 fibril formation.
abstract: Inhibiting amyloid-β (Aβ) fibril formation is the primary therapeutic strategy for Alzheimer's disease. Several small molecules and nanomaterials have been used to inhibit Aβ fibril formation. However, insufficient inhibition efficiency or poor metabolization limits their further applications. Here, we used hemin to exfoliate few-layer Bi(2)Se(3) in aqueous solution. Then we separated few-layer Bi(2)Se(3) with different sizes and thicknesses by fractional centrifugation, and used them to attempt to inhibit Aβ(1-42) aggregation. The results show that smaller and thinner few-layer Bi(2)Se(3) had the highest inhibition efficiency. We further investigated the interaction between few-layer Bi(2)Se(3) and Aβ(1-42) monomers. The results indicate that the inhibition effect may be due to the high adsorption capacity of few-layer Bi(2)Se(3) for Aβ(1-42) monomers. Few-layer Bi(2)Se(3) also decreased Aβ-mediated peroxidase-like activity and cytotoxicity according to in vitro neurotoxicity studies under physiological conditions. Therefore, our work shows the potential for applications of few-layer Bi(2)Se(3) in the biomedical field.
authors.affiliation: 1] College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China [2] College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Peng
authors.affiliation: College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Yunjing
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Lin
authors.affiliation: College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Liping
authors.initials: L
authors.lastname: Sun
authors.affiliation: 1] College of Materials, Xiamen University, Xiamen 361005, P.R. China [2] ShenZhen Research Institute of Xiamen University, Shenzhen 518057, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Weng
mesh_terms: D000641:Ammonia / Q000737:chemistry; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001729:Bismuth / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002942:Circular Dichroism; D000067493:Dynamic Light Scattering; D006427:Hemin / Q000737:chemistry* / Q000378:metabolism; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D011817:Rabbits; D018036:Selenium Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D018036:Selenium Compounds; C075222:amyloid beta-protein (1-42); D014867:Water; D006427:Hemin; D000641:Ammonia; D001729:Bismuth