title: Disseminated Aspergillosis in the Immunocompetent Host: A Case Report and Literature Review.
abstract: Disseminated aspergillosis is very rare in immunocompetent hosts and is typically associated with a poor prognosis. We describe the case of a 66-year-old, immunocompetent man who developed pneumonia, endophthalmitis and probable spondylitis caused by Aspergillus species. The patient was successfully treated with antifungal drugs. We reviewed the English-language literature between 1980 and 2012 for disseminated aspergillosis cases in immunocompetent hosts, using the keywords "dissemin*" and "aspergillo*." Disseminated aspergillosis in immunocompetent hosts is very rare in the literature. However, awareness of possible dissemination of Aspergillus spp. is necessary in patients who have a probable lung lesion and in cases with unusual presentation of a disseminated infection, even if the patient has no risk factors.
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.
authors.forename: Shinhye
authors.initials: S
authors.lastname: Cheon
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Yang
authors.forename: Chung-Jong
authors.initials: CJ
authors.lastname: Kim
authors.forename: Taek Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Kyoung-Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Woo
authors.forename: Eu Suk
authors.initials: ES
authors.lastname: Kim
authors.forename: Kyoung Un
authors.initials: KU
authors.lastname: Park
authors.forename: Hong Bin
authors.initials: HB
authors.lastname: Kim
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000175:diagnosis* / Q000473:pathology*; D001230:Aspergillus / Q000302:isolation & purification*; D009877:Endophthalmitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D013166:Spondylitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents