title: Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population.
abstract: OBJECTIVE
  Interleukin-6 (IL-6) encodes a cytokine protein, which causes inflammation, maintains immune homeostasis and plays an essential role in oral pathogenesis. The aim of this study was to evaluate the association between IL-6 (- 174 and - 572) G/C promoter gene polymorphisms and risk of OSCC among Indians.
  
  
  METHODS
  Single nucleotide polymorphism in IL-6 genes was genotyped in OSCC patients and healthy controls by PCR-RFLP method. Genotype and allele frequencies were analyzed by chi-square test and strength of associations by odds ratio with 95% confidence intervals.
  
  
  RESULTS
  Frequency distribution of IL-6 (- 174) G/C gene polymorphism was significantly associated with OSCC patients in comparison to healthy controls (OR: 0.541, CI: 0.356-0.822; p: 0.004. However, frequency of IL-6 (- 572) G/C gene polymorphism was not significantly associated with OSCC patients (p > 0.05).
  
  
  CONCLUSIONS
  The genotype GC and allele C of IL-6 (- 174) G/C gene polymorphism play a significant role in OSCC susceptibility.
authors.affiliation: Department of Anaesthesiology, King George's Medical University, Lucknow, India.
authors.forename: Prithvi Kumar
authors.initials: PK
authors.lastname: Singh
authors.affiliation: Department of Anaesthesiology, King George's Medical University, Lucknow, India.
authors.forename: Girish
authors.initials: G
authors.lastname: Chandra
authors.affiliation: Department of Anaesthesiology, King George's Medical University, Lucknow, India.
authors.forename: Jaishri
authors.initials: J
authors.lastname: Bogra
authors.affiliation: Department of Anaesthesiology, King George's Medical University, Lucknow, India.
authors.forename: Rajni
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Surgical Oncology, King George's Medical University, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Department of Microbiology, King George's Medical University, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Biochemistry, King George's Medical University, UP, Lucknow, India.
authors.forename: Syed Rizwan
authors.initials: SR
authors.lastname: Hussain
authors.affiliation: Department of Biochemistry, King George's Medical University, UP, Lucknow, India.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.affiliation: Department of Biochemistry, King George's Medical University, UP, Lucknow, India.
authors.forename: Mohammad Kaleem
authors.initials: MK
authors.lastname: Ahmad
keywords: Genotype; Immune response; Inflammation; OSCC; PCR-RFLP