title: [The role of radiotherapy in the treatment for stage-IV Hodgkin lymphoma].
abstract: The study included 140 patients with Hodgkin's lymphoma stage IV. 90 patients were exposed to chemoradiotherapy. Only chemotherapy was carried out in 50 cases. Overall survival of patients, undergone only chemotherapy, was 55% by a five-year term and 49% by a ten-year term, disease-free survival was equal to 38% as after five and ten years of observation and treatment failure-free survival--37%. Survival of patients, in the treatment program of whom after 4 or more cycles of chemotherapy combined with irradiation, including all extranodal lesions, was the best: a five-year and ten-year overall survival reached 80%, disease-free survival--70 and 61%, failure-free survival--59% and 51% respectively. Irradiation of foci of extranodal lesions after 4 or more cycles of chemotherapy resulted in a significant increase of rates of overall survival and disease-free survival regardless the presence or absence of adverse prognostic factors. Expansion of irradiation in patients with Hodgkin's lymphoma stage IV does not lead to an increase of rates of overall, disease-free and failure-free survival.
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: M M
authors.initials: MM
authors.lastname: Girshovich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018572:Disease-Free Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D016896:Treatment Outcome