title: Advanced maternal age in Indian children with thyroid dysgenesis.
abstract: A retrospective review of medical records of 80 children with thyroid dysgenesis (TD) was conducted to determine the association of gender and maternal age with TD. The study subjects were attending the Pediatric Endocrinology Clinic of our hospital which is a large tertiary care Multispecialty Pediatric Center located in Chandigarh, Northwest India. There were no gender differences (boys to girls' ratio 1:1). Mean maternal age of 25.87 ± 4.17 yrs (range 19-35 yrs) was significantly higher as compared to the mean maternal age of 23.87 ± 3.34 yrs (range 18-39 yrs) of a reference group (p < 0.0001). Odds of being older than 30 yrs were higher in mothers of children with TD as compared to mothers of normal children (OR 3.23; 95% CI: 1.54-6.44) (p-value 0.0003). In conclusion, our data shows that advanced maternal age is more prevalent in children with TD.
authors.affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Devi
authors.initials: D
authors.lastname: Dayal
authors.affiliation: Pediatric Endocrinology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: L
authors.initials: L
authors.lastname: Sindhuja
authors.affiliation: Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Anish
authors.initials: A
authors.lastname: Bhattacharya
authors.affiliation: Social Pediatrics Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Bhavneet
authors.initials: B
authors.lastname: Bharti
keywords: congenital hypothyroidism; gender differences; maternal age; thyroid dysgenesis