title: [Prevalence of hepatitis E markers in children].
abstract: OBJECTIVE
  Frequency of detection determination for past and current hepatitis E virus (HEV) infection markers in children with immune suppression, as well as children with normal immune status.
  
  
  METHODS
  The presence of HEV markers (anti-HEV IgG and IgM, HEV RNA) was studied in 609 sera samples of children with neurologic pathologies, 87 samples--from children with immune deficiencies, as well as 3122 samples from conditionally healthy children of 6 regions of Russia. The children were divided into 5 age groups. Anti-HEV IgG and IgM determination was carried out in EIA, HEV RNA--by RT-PCR.
  
  
  RESULTS
  The frequency of detection of anamnestic anti-HEV IgG turned out to be significantly higher among immune-compromised. children compared with healthy children (5.7% against 1.4%, p < 0.05). Anti-HEV IgM, that testify to current or recent infection, were also detected significantly more frequently among children with immune-suppression (1.1-1.6%) compared with healthy children (0.25%, p < 0.05). HEV RNA was detected in 1 child with the absence of anti-HEV IgM and IgG. Nucleotide sequence analysis of HEV confirmed membership of this isolate in genotype 3, that is prevalent in non-endemic territories.
  
  
  CONCLUSIONS
  The data obtained have demonstrated, that HEV-infection is prevalent among children in Russia and its course is, probably, asymptomatic in most cases. Immune suppression is a factor of increased risk of infection of children with HEV.
authors.forename: I A
authors.initials: IA
authors.lastname: Potemkin
authors.forename: M A
authors.initials: MA
authors.lastname: Lopatukhina
authors.forename: O A
authors.initials: OA
authors.lastname: Gadzhieva
authors.forename: E L
authors.initials: EL
authors.lastname: Prokhorova
authors.forename: A
authors.initials: A
authors.lastname: Diyarrassuba
authors.forename: O A
authors.initials: OA
authors.lastname: Isaeva
authors.forename: T V
authors.initials: TV
authors.lastname: Kozhanova
authors.forename: O E
authors.initials: OE
authors.lastname: Ivanova
authors.forename: O V
authors.initials: OV
authors.lastname: Silenova
authors.forename: N Kh
authors.initials: NKh
authors.lastname: Setdikova
authors.forename: K K
authors.initials: KK
authors.lastname: Kyuregyan
authors.forename: M I
authors.initials: MI
authors.lastname: Mikhailov
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood*; D016751:Hepatitis E / Q000097:blood / Q000453:epidemiology* / Q000276:immunology* / Q000821:virology; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood*; D012426:Russia / Q000453:epidemiology; D017423:Sequence Analysis, RNA; D055815:Young Adult
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral