title: Development of an endoluminal intestinal lengthening device using a geometric intestinal attachment approach.
abstract: BACKGROUND
  Distraction enterogenesis may provide a novel therapy for short bowel syndrome. Previously described methods have relied on isolated intestinal segments or transmural fixation because of ineffective endoluminal attachment. We hypothesized that a novel approach of geometric coupling between a tapering device and the mesenteric curvature would allow trans-stomal distraction enterogenesis.
  
  
  METHODS
  A catheter device was designed with tapering stiffness, consisting of a stiff catheter with a taper to a flexible latex tip to prevent perforation. Yorkshire pigs underwent creation of a jejunal Roux limb with device placed via jejunostomy. Intestinal attachment was achieved without a substantial decrease in bowel perfusion as measured by laser Doppler. An external clamp was secured at the stoma to provide external fixation of the device. The catheter was advanced 1 cm/day for either 7 or 14 days before explant.
  
  
  RESULTS
  After 7 days, the distracted segment achieved a mean ± SD increase in length of 37 ± 6% versus fed, nondistracted bowel, corresponding to an absolute gain of 10.6 ± 1.7 cm (1.5 cm/day). After 14 days, the Roux limb achieved an 80 ± 2% increase in length versus fed control bowel, corresponding to an absolute gain of 16.8 ± 3.0 cm (1.2 cm/day). No perforation or stoma-related complication occurred.
  
  
  CONCLUSIONS
  We describe a novel catheter device with tapering stiffness allowing for endoluminal distraction enterogenesis via geometric coupling. This approach may allow development of clinically applicable technology for the treatment of patients with short bowel syndrome.
authors.affiliation: Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
authors.forename: Farokh R
authors.initials: FR
authors.lastname: Demehri
authors.affiliation: Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Freeman
authors.affiliation: Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fukatsu
authors.affiliation: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Luntz
authors.affiliation: Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. Electronic address: dttlbm@umich.edu.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Teitelbaum
mesh_terms: D000818:Animals; D057785:Catheters; D004867:Equipment Design; D005260:Female; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery; D007582:Jejunostomy; D008643:Mesentery; D012778:Short Bowel Syndrome / Q000628:therapy*; D054047:Surgical Stomas; D013552:Swine