title: Cyclin E Expression Correlates with Cancer-specific Survival in Endometrial Endometrioid Adenocarcinoma.
abstract: OBJECTIVE
  The aim of the present study was to investigate the impact of cyclin E expression on cancer-specific survival, as well as on conventional clinocopathological and prognostic factors in endometrial endometrioid adenocarcinoma.
  
  
  METHODS
  The study consisted of 211 patients surgically treated for endometrial endometrioid adenocarcinoma at the Oulu University Hospital between 1992-2000. Tissue samples were immunohistochemically stained for cyclin E and clinicopathological data were retrospectively retrieved from the patients' records.
  
  
  RESULTS
  Cyclin E expression correlated with grade but not with the Fédération Internationale de Gynécologie Obstétrique (FIGO) stage or myometrial invasion. Univariate and multivariate survival analyses were performed between patients grouped according to a receiver operating characteristic (ROC) curve-derived cut-off value. A statistically significant difference in survival was demonstrated between patient groups in Kaplan-Meier analysis.
  
  
  CONCLUSIONS
  Contrary to previous literature, we found a correlation between cyclin E expression and prognosis. Further large-scale studies are required to confirm our findings.
authors.affiliation: Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland.
authors.forename: Simi
authors.initials: S
authors.lastname: Santala
authors.affiliation: Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland.
authors.forename: Anne
authors.initials: A
authors.lastname: Talvensaari-Mattila
authors.affiliation: Department of Pathology, Oulu University Hospital, Oulu, Finland Department of Pathology and Forensic Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, School of Medicine, Cancer Centre of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
authors.forename: Ylermi
authors.initials: Y
authors.lastname: Soini
authors.affiliation: Department of Obstetrics and Gynaecology, Oulu University Hospital, Oulu, Finland markku.santala@oulu.fi.
authors.forename: Markku
authors.initials: M
authors.lastname: Santala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000473:pathology; D019927:Cyclin E / Q000096:biosynthesis* / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis
chemical_list: D019927:Cyclin E
keywords: CDKs; Cyclin E; cyclins; endometrial adenocarcinoma; prognosis