title: [Obesity as pathology of adipocytes: number of cells, volume of arterial bloodstream,local pools of circulation in vivo, natriuretic peptides and arterial hypertension].
abstract: The non-specific systemic biological reaction of arterial pressure from the level of organism. vasomotor center and proximal section of arterial bloodstream is appealed to compensate disorders of metabolism and microcirculation in distal section of arteries. This phenomenon occurs in several cases. The primarily local disorders of metabolism at autocrine level, physiological (aphysiological) death of cells, "littering" of intercellular medium become the cause of disorder of microcirculation in paracrin cenosises and deteriorate realization of biological functions of homeostasis, trophology, endoecology and adaptation. The local compensation of affected perfusion in paracrin cenosises at the expense of function of peripheral peristaltic pumps, redistribution of local bloodflow in biological reaction of endothelium-depended vaso-dilation has no possibility to eliminate disorders in realization of biological functions. The systemic increase of arterial pressure under absence of specific symptoms of symptomatic arterial hypertension is a test to detect disorder of biological functions of homeostasis, trophology, biological function of endoecology and adaptation. Allforms of arterial hypertension develop by common algorithm independently from causes of disorders of blood flow, microcirculation in distal section of arteries. The non-specific systemic compensation ofdisorders of metabolism from level of organism, in proximal section of arterial bloodstream always is the same one and results in aphysiological alterations in organs-targets. To comprehend etiological characteristics of common pathogenesis of arterial hypertension is possible in case of application of such technically complicated and still unclear in differential diagnostic of deranged functions modes of metabolomics.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
authors.forename: V A
authors.initials: VA
authors.lastname: Dmitriev
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D001158:Arteries / Q000378:metabolism / Q000503:physiopathology; D001794:Blood Pressure / Q000235:genetics; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D055432:Metabolomics; D045265:Natriuretic Peptides / Q000378:metabolism*; D009765:Obesity / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D045265:Natriuretic Peptides