title: Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.
abstract: New carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases were synthesized and evaluated as potential anti-HIV and anti-HCV agents. Among the synthesized carbocyclic nucleoside analogs, the pyrazole amide15fexhibited modest selective anti-HIV-1 activity (EC50= 24 µM).
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30322, USA.
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Cho
authors.affiliation: RFS Pharma, 1860 Montreal Road Tucker, GA 30084, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Coats
authors.affiliation: Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Veterans Affairs Medical Center, Atlanta, GA 30322, USA.
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
keywords: antiviral; carbocyclic ribonucleoside; five-membered nucleobases