title: A Facile Multi-interface Transformation Approach to Monodisperse Multiple-Shelled Periodic Mesoporous Organosilica Hollow Spheres.
abstract: The synthesis of well-defined and complex hollow structures via a simple method is still a major challenge. In this work, a facile and controllable "multi-interface transformation" approach for preparation of monodisperse multi-shelled periodic mesoporous organosilica (PMO) hollow spheres has been established by a one-step hydrothermal treatment of successively grown organosilica particles. The multi-shelled PMO hollow spheres have inorganic-organic hybrid frameworks, controllable number (1-4) of shells, high surface area (∼805 m(2)/g), accessible ordered mesochannels (∼3.2 nm), large pore volume (1.0 cm(3)/g), and uniform and tunable diameter (300-550 nm), chamber size (4-54 nm), and shell thickness (10-30 nm). In addition, various organic groups (alkyl, aromatic, and heteroelement fragments) are successfully incorporated into the multi-shelled PMO hollow spheres by successively adding different bridged organosilica precursors. Notably, the distribution of different kinds of organic groups in the multi-shelled PMO hollow spheres can be precisely controlled, showing great potential for future applications. We propose that the formation of the multi-shelled PMO hollow structures is ascribed to the creation of multiple highly cross-linked organosilica interfaces, providing a new and interesting fundamental principle for PMO materials. Due to their unique structure and frameworks, triple-shelled ethane-bridged PMO hollow spheres were successfully loaded with an anti-cancer drug doxorubicin and perfluoropentane gas, which present excellent effects in the killing of cancer cells and ultrasound imaging. It is expected that the multi-interface transformation strategy provides a simple, controllable, versatile, and template-free method for preparation of various multifunctional PMOs for different applications.
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.|‡State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, Jiangsu, P.R. China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Teng
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Su
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Shouju
authors.initials: S
authors.lastname: Wang
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Guotao
authors.initials: G
authors.lastname: Chen
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
authors.affiliation: ⊥Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P.R. China.
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
authors.affiliation: †Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu, P.R. China.|‡State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, Jiangsu, P.R. China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Lu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D045744:Cell Line, Tumor; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D017646:Organosilicon Compounds / Q000737:chemistry*; D044367:Phase Transition; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D002593:Cetrimonium Compounds; D004337:Drug Carriers; D017646:Organosilicon Compounds; D013501:Surface-Active Agents; D012822:Silicon Dioxide; D004317:Doxorubicin; D000077286:Cetrimonium