title: Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: a pilot study to assess effects on the central nervous system.
abstract: In a substudy of a clinical trial, we assessed whether activation of latent human immunodeficiency virus (HIV) by the histone deacetylase inhibitor panobinostat had detrimental effects on the central nervous system (CNS). Adults infected with HIV received oral panobinostat 20 mg 3 times per week every other week for 8 weeks. In cerebrospinal fluid (CSF), we assayed panobinostat concentration, HIV RNA, and the level of neuroinflammatory or degenerative biomarkers in 11 individuals before and during study therapy. Neither panobinostat nor HIV RNA was detected in CSF. In addition, there was no change from baseline in CSF biomarkers. Thus, panobinostat administration was not associated with CNS adverse effects as assessed by CSF biomarkers.
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Rasmussen
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Martin
authors.initials: M
authors.lastname: Tolstrup
authors.affiliation: Clinical Biochemistry.
authors.forename: Holger Jon
authors.initials: HJ
authors.lastname: Møller
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Christel R
authors.initials: CR
authors.lastname: Brinkmann
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Rikke
authors.initials: R
authors.lastname: Olesen
authors.affiliation: Clinical Immunology , Aarhus University Hospital , Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Alex L
authors.initials: AL
authors.lastname: Laursen
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Lars
authors.initials: L
authors.lastname: Østergaard
authors.affiliation: Departments of Infectious Diseases.
authors.forename: Ole S
authors.initials: OS
authors.lastname: Søgaard
keywords: central nervous system; cerebrospinal fluid; histone deacetylase inhibitors; human immunodeficiency virus; panobinostat