title: Podosomes: Multipurpose organelles?
abstract: Thirty years of research have accumulated ample evidence that podosome clusters qualify as genuine cellular organelles that are being found in more and more cell types. A podosome is a dynamic actin-based and membrane-bound microdomain and the organelle consists in an interconnected network of such basic units, forming a cytoskeletal superstructure linked to the plasma membrane. At this strategic location, podosomes are privileged sites of interactions with the pericellular environment that regulates their formation, density, lifetime, distribution, architecture and functioning. Actin polymerization is the driving force behind most podosome characteristics. In contrast to classical organelles, podosomes are not vital at the cell level but rather serve diverse and often intricate functions of which adhesion, matrix degradation and substrate sensing are the most established. These capabilities involve specific molecules, depend on podosome organization and may vary according to the cell type in which they form. Podosome-associated diseases manifest by loss or gain of podosome functions and include genetic diseases affecting podosome components and various cancers where tumor cells ectopically express podosome equivalents (invadopodia).
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Veronique
authors.initials: V
authors.lastname: Veillat
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Pirjo
authors.initials: P
authors.lastname: Spuul
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Daubon
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Isabel
authors.initials: I
authors.lastname: Egaña
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France.
authors.forename: Ijsbrand
authors.initials: I
authors.lastname: Kramer
authors.affiliation: Université de Bordeaux, Bordeaux, France; INSERM, U1045, Bordeaux, France; IECB, 2 rue Robert Escarpit, 33600 Pessac, France. Electronic address: Elisabeth.genot@inserm.fr.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Génot
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D000069261:Podosomes / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
keywords: Cytoskeleton; Invasion; Microenvironment; Organelle; Podosomes