title: Tumor promotion by γ and suppression by β non-muscle actin isoforms.
abstract: Here we have shown that β-cytoplasmic actin acts as a tumor suppressor, inhibiting cell growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other regulatory proteins. There is a positive feedback loop between γ-actin expression and ERK1/2 activation. We conclude that non-muscle actin isoforms should not be considered as merely housekeeping proteins and the β/γ-actins ratio can be used as an oncogenic marker at least for lung and colon carcinomas. Agents that increase β- and/or decrease γ-actin expression may be useful for anticancer therapy.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Vera
authors.initials: V
authors.lastname: Dugina
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Natalya
authors.initials: N
authors.lastname: Khromova
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Vera
authors.initials: V
authors.lastname: Rybko
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Oleg
authors.initials: O
authors.lastname: Blizniukov
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
authors.forename: Galina
authors.initials: G
authors.lastname: Shagieva
authors.affiliation: Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland.
authors.forename: Christine
authors.initials: C
authors.lastname: Chaponnier
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Boris
authors.initials: B
authors.lastname: Kopnin
authors.affiliation: Blokhin Russian Cancer Research Center, Moscow, Russia.
authors.forename: Pavel
authors.initials: P
authors.lastname: Kopnin
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D051338:Cofilin 1 / Q000235:genetics / Q000378:metabolism*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal / Q000379:methods*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000199:Actins; C495811:Cfl1 protein, mouse; D051338:Cofilin 1; D020033:Protein Isoforms
keywords: ERK1/2; PP1; WAVE; actin isoforms; cancer; cofilin1; p34-Arc