title: Neurotrophic factors in tension-type headache.
abstract: Neurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH). We carried out a cross sectional study including 48 TTH patients and 48 age and gender matched controls. Beck Depression and Anxiety Inventories, and Headache Impact Test were recorded. Serum levels of NF were determined by ELISA. There were not significant differences between NF levels between TTH patients and controls. Patients with chronic and episodic TTH had not significant differences in NF levels. The presence of headache at the time of evaluation did not significantly alter the levels of NF. Depression and anxiety scores as well as headache impact did not correlate with NF levels. Our study suggest that the serum levels of NF are not altered in TTH.
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Renan B
authors.initials: RB
authors.lastname: Domingues
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Halina
authors.initials: H
authors.lastname: Duarte
authors.affiliation: Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Natália P
authors.initials: NP
authors.lastname: Rocha
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D001007:Anxiety / Q000097:blood / Q000503:physiopathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D020933:Neurotrophin 3; D011594:Psychometrics; D017475:Receptors, Nerve Growth Factor / Q000097:blood; D012016:Reference Values; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D018781:Tension-Type Headache / Q000097:blood* / Q000503:physiopathology; D055815:Young Adult
chemical_list: C000595808:NTF3 protein, human; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D017475:Receptors, Nerve Growth Factor; C089191:neurotrophin 4(5) receptor