title: A perspective on the enhancer dependent bacterial RNA polymerase.
abstract: Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression. We consider what gaps exist in our understanding of its genetic, biochemical and biophysical functioning and how they might be addressed.
authors.affiliation: Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK. nan.zhang@imperial.ac.uk.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK. m.buck@imperial.ac.uk.
authors.forename: Martin
authors.initials: M
authors.lastname: Buck
mesh_terms: D000595:Amino Acid Sequence; D004742:Enhancer Elements, Genetic; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D051877:RNA Polymerase Sigma 54 / Q000737:chemistry / Q000378:metabolism*; D012808:Sigma Factor / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D029968:Escherichia coli Proteins; D012808:Sigma Factor; C497751:rpoN protein, E coli; D051877:RNA Polymerase Sigma 54
keywords: AAA+ ATPase; RNA polymerase; Sigma54; transcription