title: Idiopathic sudden sensorineural hearing loss: cardiovascular risk factors do not influence hearing threshold recovery.
abstract: Previous studies have suggested that risk factors for ischaemic vascular disease, such as cigarette smoking, hypertension and hyperlipidaemia, can also be considered risk factors for the development of idiopathic sudden sensorineural hearing loss (ISSNHL). In this study, we have evaluated the hypothesis that these factors can influence hearing threshold recovery in patients affected by ISSNHL. A total of 141 subjects who suffered an episode of ISSNHL were included. All subjects were assessed with tonal audiometry, auditory brainstem responses and MRI to exclude retrocochlear pathology. Hearing tests were conducted at ISSNHL onset (t = 0) and after 30 days. Patients were divided into three classes according to the presence/absence of one or more cardiovascular risk factors including: history of smoking, total serum cholesterol/triglycerides, history of hypertension and diabetes mellitus. Values of hearing threshold recovery were estimated and comparisons were conducted across the three risk factor classes. 75% of patients affected by ISSNHL showed a threshold recovery. However, the threshold recovery was found to be class-independent (average recovery value of 18 dB HL per classes) and also independent of age and gender. Even if cardiovascular risk factors have been found to be involved in the pathogenesis of ISSNHL, the present study suggests that these factors do not have any significant influence on the threshold recovery in ISSNHL.
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: A
authors.initials: A
authors.lastname: Ciorba
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: S
authors.initials: S
authors.lastname: Hatzopoulos
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: C
authors.initials: C
authors.lastname: Bianchini
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: V
authors.initials: V
authors.lastname: Iannini
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: M
authors.initials: M
authors.lastname: Rosignoli
authors.affiliation: Institute of Pathology and Physiology of Hearing, Warsaw, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Skarzynski
authors.affiliation: ENT and Audiology Department, University Hospital of Ferrara, Italy;
authors.forename: C
authors.initials: C
authors.lastname: Aimoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001309:Auditory Threshold; D002318:Cardiovascular Diseases / Q000150:complications*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D003639:Hearing Loss, Sudden / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Cardiovascular risk factors; Idiopathic sudden sensorineural hearing loss; Threshold recovery