title: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex.
abstract: DNA methylation is an epigenetic repressor mark for transcription dynamically regulated in neurons. We analyzed visual experience regulation of DNA methylation in mice and its involvement in ocular dominance plasticity of the developing visual cortex. Monocular deprivation modulated the expression of factors controlling DNA methylation and exerted opposite effects on DNA methylation and hydroxymethylation in specific plasticity genes. Inhibition of DNA methyltrasferase (DNMT) blocked molecular and functional effects of monocular deprivation, partially reversing the monocular deprivation transcriptional program.
authors.affiliation: Institute of Neuroscience CNR, Pisa, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Tognini
authors.affiliation: 1] Institute of Neuroscience CNR, Pisa, Italy. [2] BioSNS, Scuola Normale Superiore di Pisa, Pisa, Italy.
authors.forename: Debora
authors.initials: D
authors.lastname: Napoli
authors.affiliation: Institute of Neuroscience CNR, Pisa, Italy.
authors.forename: Jonida
authors.initials: J
authors.lastname: Tola
authors.affiliation: Institute of Neuroscience CNR, Pisa, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Silingardi
authors.affiliation: 1] Institute of Genetics and Biophysics "A. Buzzati Traverso" CNR via P. Castellino, Napoli, Italy. [2] IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Floriana
authors.initials: F
authors.lastname: Della Ragione
authors.affiliation: 1] Institute of Genetics and Biophysics "A. Buzzati Traverso" CNR via P. Castellino, Napoli, Italy. [2] IRCCS INM Neuromed, Pozzilli, IS, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: D'Esposito
authors.affiliation: 1] Institute of Neuroscience CNR, Pisa, Italy. [2] Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Firenze, Italy.
authors.forename: Tommaso
authors.identifier: 0000000156140668
authors.initials: T
authors.lastname: Pizzorusso
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology*; D023882:Dominance, Ocular / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology*; D014793:Visual Cortex / Q000254:growth & development* / Q000378:metabolism