title: Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress.
abstract: Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.
authors.affiliation: 1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Christoffel
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Sam A
authors.identifier: 0000000221042272
authors.initials: SA
authors.lastname: Golden
authors.affiliation: 1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Jessica J
authors.initials: JJ
authors.lastname: Walsh
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Guise
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Mitra
authors.initials: M
authors.lastname: Heshmati
authors.affiliation: Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Allyson K
authors.initials: AK
authors.lastname: Friedman
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Aditi
authors.initials: A
authors.lastname: Dey
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Milo
authors.initials: M
authors.lastname: Smith
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Rebusi
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Madeline
authors.initials: M
authors.lastname: Pfau
authors.affiliation: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Ables
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Hossein
authors.initials: H
authors.lastname: Aleyasin
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Lena A
authors.initials: LA
authors.lastname: Khibnik
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Georgia E
authors.initials: GE
authors.lastname: Hodes
authors.affiliation: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
authors.forename: Gabriel A
authors.initials: GA
authors.lastname: Ben-Dor
authors.affiliation: 1] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. [2] Department of Bioengineering, Stanford University, Stanford, California, USA.
authors.forename: Karl
authors.initials: K
authors.lastname: Deisseroth
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Shapiro
authors.affiliation: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Malenka
authors.affiliation: Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
authors.forename: Ines
authors.initials: I
authors.lastname: Ibanez-Tallon
authors.affiliation: 1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Ming-Hu
authors.initials: MH
authors.lastname: Han
authors.affiliation: Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Russo
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D049229:Dendritic Spines / Q000502:physiology*; D004198:Disease Susceptibility; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D012201:Reward; D012919:Social Behavior; D013315:Stress, Psychological / Q000503:physiopathology*; D013788:Thalamus / Q000502:physiology*; D066328:Ventral Striatum / Q000166:cytology / Q000502:physiology*