title: A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men.
abstract: Overweight and obesity are associated to increased risk of developing non-communicable diseases that might dramatically affect life expectancy according World Health Organization. Overweight, obesity, and decline in physical activity are correlated to a significant propensity to lose skeletal muscle mass as a result of prolonged inflammation and oxidative stress whereas cohort surveys and clinical investigations have demonstrated health benefits of Citrus-based polyphenols to reverse such regression. Overweight men were included in a double-blind, randomized, parallel pilot trial where they received daily for a 12-week period 900 mg of a Citrus-based polyphenol extract, Sinetrol® XPur. Body composition, anthropometric, and blood parameters were assessed before and at the end of the intervention period. After 12 weeks, while the silhouette slimmed down, metabolic parameters were significantly improved and skeletal muscle catabolism held back. These data suggest that over a 12-week period, the efficacy of the supplement improve both overweight process and correlated skeletal muscle mass metabolism.
authors.affiliation: Innovation and Scientific Affairs, Fytexia SAS, ZAE via Europe , Vendres , France .
authors.forename: Julien
authors.initials: J
authors.lastname: Cases
authors.forename: Cindy
authors.initials: C
authors.lastname: Romain
authors.forename: Constantin
authors.initials: C
authors.lastname: Dallas
authors.forename: Alain
authors.initials: A
authors.lastname: Gerbi
authors.forename: Jean Max
authors.initials: JM
authors.lastname: Rouanet
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects*; D000328:Adult; D001835:Body Weight / Q000187:drug effects*; D002957:Citrus; D019587:Dietary Supplements; D004311:Double-Blind Method; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D009133:Muscular Atrophy / Q000378:metabolism / Q000517:prevention & control; D050177:Overweight / Q000378:metabolism*; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use; D059808:Polyphenols / Q000627:therapeutic use*; D055105:Waist Circumference / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols
keywords: Abdominal fat; inflammation; insulin resistance; obesity; polyphenols; weight loss