title: Is local resection sufficient for parathyroid carcinoma?
abstract: OBJECTIVE
  Parathyroid carcinoma is a rare malignant disease of the parathyroid glands that appears in less than 1% of patients with primary hyperparathyroidism. In the literature, the generally recommended treatment is en bloc tumor excision with ipsilateral thyroid lobectomy. Based on our 12 years of experience, we discuss the necessity of performing thyroid lobectomy on parathyroid carcinoma patients.
  
  
  RESULTS
  Eleven parathyroid carcinoma cases were included in the study. All operations were performed at the Department of Endocrine Surgery at Ankara University Medical School. Seven of the patients were male (63.6%), and the mean patient age was 48.9 ± 14.0 years. Hyperparathyroidism was the most common indication for surgery (n ϝ 10, 90.9%). Local disease was detected in 5 patients (45.5%), invasive disease was detected in 5 patients (45.5%) and metastatic disease was detected in 1 patient (9.1%). The mean follow-up period was 99.6 ± 42.1 months, and the patients' average disease-free survival was 96.0 ± 49.0 months. During the follow-up period, only 1 patient died of metastatic parathyroid carcinoma.
  
  
  CONCLUSIONS
  Parathyroid carcinoma has a slow-growing natural progression, and regional lymph node metastases are uncommon. Although our study comprised few patients, it nevertheless showed that in selected cases, parathyroid carcinoma could be solely treated with parathyroidectomy.
authors.affiliation: General Surgery, Islahiye State Hospital, Gaziantep, Turkey.
authors.forename: Salim Ilksen
authors.initials: SI
authors.lastname: Basceken
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Genc
authors.affiliation: Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Siyar
authors.initials: S
authors.lastname: Ersoz
authors.affiliation: General Surgery, Ankara Penal Institution Campus State Hospital, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sevim
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Suleyman Utku
authors.initials: SU
authors.lastname: Celik
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Ilknur Kepenekci
authors.initials: IK
authors.lastname: Bayram
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010282:Parathyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D016105:Parathyroidectomy / Q000379:methods; D012189:Retrospective Studies; D013965:Thyroidectomy / Q000379:methods; D016896:Treatment Outcome