title: Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study.
abstract: This study aimed to analyze the influence of H. pylori infection on insulin resistance and metabolic syndrome (MS) by multivariate analysis of a community-based cohort study. From January 2013 to February 2014,811 subjects were enrolled in a community-based cohort study from the northeastern region of Taiwan. All subjects received a demographic survey and blood tests, including an H. pylori antibody test, liver biochemistry tests, lipid profiles, sugar/insulin levels for Homeostatic model assessment (HOMA-IR index), and measurements of adipokines and inflammatory cytokines. A total of 264 men and 547 women were included in this study. The mean age was 59.2 ± 12.7 years. Subjects seropositive for H. pylori antibodies exhibited higher rates of hypertension, an increased incidence of a HOMA-IR index > 2.5 and a higher level of tumor necrosis factor-α than those without H. pylori antibodies. We found a significant difference in the presence of H. pylori antibodies between subjects with MS and those without MS (76.7% vs. 53.7%, p = 0.007) among subjects < 50 y/o. A HOMA-IR index >2.5, H. pylori antibody presence and leptin were predictors for MS in subjects < 50 y/o. The estimated odds ratio of MS for a subject with H. pylori antibodies was 3.717 (95% CI = 1.086-12.719) times that of a subject without H. pylori antibodies. In addition, no difference in H. pylori antibody status was detected for MS prediction in subjects that were ≧ 50 y/o (p = 0.861). In conclusion, subjects with H. pylori antibodies had a higher incidence of a HOMA-IR >2.5 than those without H pylori antibodies. For subjects aged < 50 y/o, the H. pylori antibody was a predictor for MS.
authors.affiliation: Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung, Taiwan; Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Chen
authors.affiliation: Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Chih-Yi
authors.initials: CY
authors.lastname: Chien
authors.affiliation: Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Kai-Jie
authors.initials: KJ
authors.lastname: Yang
authors.affiliation: Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan; Metabolism and Endocrinology, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Sheng-Fong
authors.initials: SF
authors.lastname: Kuo
authors.affiliation: Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan; Metabolism and Endocrinology, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Chih-Hung
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital and University, Keelung, Taiwan; Community Medicine Research Center, Chang-Gung Memorial Hospital and University, Keelung, Taiwan.
authors.forename: Rong-Nan
authors.initials: RN
authors.lastname: Chien
mesh_terms: D000367:Age Factors; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology; D008875:Middle Aged; D013624:Taiwan
chemical_list: D000907:Antibodies, Bacterial; D020738:Leptin