title: Antiproliferative Compounds fromOcotea macrocarpafrom the Madagascar Dry Forest1.
abstract: Bioassay-directed fractionation of an antiproliferative ethanol extract of the roots ofOcotea macrocarpa(Lauraceae) afforded the new butanolide macrocarpolide A (1), and the two new secobutanolides macrocarpolides B (2) and C (3), together with the known butanolides linderanolide B (4) and isolinderanolide (5). The structure elucidation of all compounds was carried out based on NMR and mass spectroscopic data analyses. The absolute configurations of all compounds isolated were determined by comparison of their optical rotation values with those found in literature. Compounds1-5showed good antiproliferative activities against the A2780 ovarian cell line, with IC50values of 2.57 ± 0.12 (1), 1.98 ± 0.23 (2), 1.67 ± 0.05 (3), 2.43 ± 0.41 (4), and 1.65 ± 0.44 µM (5), respectively.
authors.affiliation: Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061.
authors.forename: Emily
authors.initials: E
authors.lastname: Cheng
authors.affiliation: Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061.
authors.forename: L Harinantenaina
authors.initials: LH
authors.lastname: Rakotondraibe
authors.affiliation: Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061.
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.affiliation: Missouri Botanical Garden, P.O. Box 299, St. Louis Missouri 63166.
authors.forename: Wendy
authors.initials: W
authors.lastname: Applequist
authors.affiliation: Missouri Botanical Garden, Lot VP 31 Ankadibevava, Anjohy Antananarivo 101, Madagascar.
authors.forename: Richard
authors.initials: R
authors.lastname: Randrianaivo
authors.affiliation: Missouri Botanical Garden, Lot VP 31 Ankadibevava, Anjohy Antananarivo 101, Madagascar.
authors.forename: Andriamalala
authors.initials: A
authors.lastname: Rakotondrafara
authors.affiliation: Centre National d'Application des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar.
authors.forename: Michel
authors.initials: M
authors.lastname: Ratsimbason
authors.affiliation: Centre National d'Application des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar.
authors.forename: Vincent E
authors.initials: VE
authors.lastname: Rasamison
authors.affiliation: Department of Chemistry and the Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061.
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
keywords: Antiproliferative activity; Butanolide; Lauraceae; Ocotea macrocarpa