title: [Surfactant and water balance of lung in intracerebral hemorrhage at conditions of capsaicin blockade of vagus nerve].
abstract: It is known that intracranial hemorrhage (ICH) is accompanied by the development of neurogenic pulmonary edema and insufficiency of surfactant function. The present study was undertaken for evaluation of the role of vagal afferents in the mechanisms of ICH effects on pulmonary surfactant and water balance of the lung. We explored the surface activity and biochemical composition of surfactant, as well as blood supply, total, intravascular and extravascular fluid content in lung after ICH, simulated by intraventricular administration of autologous blood against the background of bilateral blockade of capsaicin-sensitive vagal affere its. The blockade was caused by the capsaicin application (50 mcmol) on the cervical part of the nerves. Intracerebralhemorrhage was accompanied by the decrease of surfactant activity which appeared by the enhancement of minimal, maximal and static surface tension of bronchoalveolar lavage fluid (BAL), the reduction of total phospholipids including their main fraction phosphatidylcholine, the increase of lysophosphatidyicholine content and hyperhydration of the lung. The level of total proteins in BAL elevated, confirmed the enhanced permeability of the alveolar-blood barrier. The exhaustion of neuropeptides in capsaicin-sensitive vagal afferents led to the partial restoration of surface active properties of lung, normalization of phospholipids and protein contents and water balance parameters. The obtained results suggest that capsaicin-sensitive vagal afferents play a pivotal role in the disturbances of surfactant function and water balance of the lung after ICH.
authors.forename: M A
authors.initials: MA
authors.lastname: Urakova
authors.forename: I G
authors.initials: IG
authors.lastname: Bryndina
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000008:administration & dosage*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D010743:Phospholipids / Q000378:metabolism; D011654:Pulmonary Edema / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D014630:Vagus Nerve / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology
chemical_list: D010743:Phospholipids; D011663:Pulmonary Surfactants; D002211:Capsaicin