title: Peptic ulcer frequency differences related to h. Pylori or aines.
abstract: BACKGROUND
  Peptic ulcer etiology has been changing because of H. pylori decline.
  
  
  OBJECTIVE
  To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. Methods Records assessment in two periods: A (1997-2000) and B (2007-2010), searching for peptic ulcer, H. pylori infection and non-steroidal anti-inflammatory drugs use.
  
  
  RESULTS
  Peptic ulcer occurred in 30.35% in A and in 20.19% in B. H. pylori infection occurred in 73.3% cases in A and in 46.4% in B. Non-steroidal anti-inflammatory drugs use was 3.5% in A and 13.3% in B. Neither condition occurred in 10.4% and 20.5% in A and B respectively. Comparing both periods, we observed reduction of peptic ulcer associated to H. pylori (P=0.000), increase of peptic ulcer related to non-steroidal anti-inflammatory drugs (P=0.000) and idiopathic peptic ulcer (P=0.002). The concurrent association of H. pylori and non-steroidal anti-inflammatory drugs was also higher in B (P=0.002). Rates of gastric ulcer were higher and duodenal ulcer lower in the second period.
  
  
  CONCLUSIONS
  After 10 years, the prevalence of peptic ulcer decreased, as well as ulcers related to H. pylori whereas ulcers associated to non-steroidal anti-inflammatory drugs increased. There was an inversion in the pattern of gastric and duodenal ulcer and a rise of idiopathic peptic ulcer.
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
authors.forename: Diego Michelon de
authors.initials: DM
authors.lastname: Carli
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
authors.forename: Rafael Cardoso
authors.initials: RC
authors.lastname: Pires
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
authors.forename: Sofia Laura
authors.initials: SL
authors.lastname: Rohde
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
authors.forename: Caroline Mayara
authors.initials: CM
authors.lastname: Kavalco
authors.affiliation: Departamento de Clínica Médica, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
authors.forename: Renato Borges
authors.initials: RB
authors.lastname: Fagundes
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000453:epidemiology / Q000382:microbiology*; D015995:Prevalence; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal