title: Interoceptive predictions in the brain.
abstract: Intuition suggests that perception follows sensation and therefore bodily feelings originate in the body. However, recent evidence goes against this logic: interoceptive experience may largely reflect limbic predictions about the expected state of the body that are constrained by ascending visceral sensations. In this Opinion article, we introduce the Embodied Predictive Interoception Coding model, which integrates an anatomical model of corticocortical connections with Bayesian active inference principles, to propose that agranular visceromotor cortices contribute to interoception by issuing interoceptive predictions. We then discuss how disruptions in interoceptive predictions could function as a common vulnerability for mental and physical illness.
authors.affiliation: Northeastern University, Department of Psychology, Boston, Massachusetts 02115, USA; and the Massachusetts General Hospital, Department of Psychiatry and the Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA.
authors.forename: Lisa Feldman
authors.initials: LF
authors.lastname: Barrett
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma 74133, USA; and the Faculty of Community Medicine, University of Tulsa, Tulsa, Oklahoma 74104, USA.
authors.forename: W Kyle
authors.initials: WK
authors.lastname: Simmons
mesh_terms: D001364:Awareness / Q000502:physiology; D001499:Bayes Theorem; D001921:Brain / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism / Q000523:psychology; D009415:Nerve Net / Q000378:metabolism*; D010465:Perception / Q000502:physiology*