title: Basic biology and therapeutic implications of lncRNA.
abstract: Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE consortia, have been a subject of intense investigation in the past decade. Extensive efforts to get deeper understanding of lncRNA biology have yielded evidence of their diverse structural and regulatory roles in protecting chromosome integrity, maintaining genomic architecture, X chromosome inactivation, imprinting, transcription, translation and epigenetic regulation. Here we will briefly review the recent studies in the field of lncRNA biology focusing mostly on mammalian species and discuss their therapeutic implications.
authors.affiliation: OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
authors.forename: O
authors.initials: O
authors.lastname: Khorkova
authors.affiliation: OPKO Health Inc., 10320 USA Today Way, Miramar, FL 33025, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hsiao
authors.affiliation: Center for Therapeutic Innovation and the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1501 NW 10th Avenue, Miami 33136, FL, USA. Electronic address: CWahlestedt@med.miami.edu.
authors.forename: C
authors.initials: C
authors.lastname: Wahlestedt
mesh_terms: D000818:Animals; D043171:Chromosomal Instability; D044127:Epigenesis, Genetic; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage / Q000627:therapeutic use; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000097:blood / Q000235:genetics* / Q000652:urine; D013045:Species Specificity; D016615:Telomere / Q000235:genetics
chemical_list: D016376:Oligonucleotides, Antisense; D062085:RNA, Long Noncoding
keywords: AntagoNAT; Epigenetic regulation; Imprinting; Natural antisense transcripts; Paraspeckles; Telomeres; lincRNA; vlincRNA