title: [Frontiers in Live Bone Imaging Researches. Novel drug discovery by means of intravital bone imaging technology].
abstract: Recent advances in intravital bone imaging technology has enabled us to grasp the real cellular behaviors and functions in vivo , revolutionizing the field of drug discovery for novel therapeutics against intractable bone diseases. In this chapter, I introduce various updated information on pharmacological actions of several antibone resorptive agents, which could only be derived from advanced imaging techniques, and also discuss the future perspectives of this new trend in drug discovery.
authors.affiliation: Department of Immunology and Cell Biology, Graduate School of Medicine & Frontier Biosciences, Osaka University, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D001847:Bone Diseases / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends*; D005456:Fluorescent Dyes; D005544:Forecasting; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends*; D058990:Molecular Targeted Therapy; D010010:Osteoclasts / Q000473:pathology / Q000502:physiology; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology
chemical_list: D050071:Bone Density Conservation Agents; D005456:Fluorescent Dyes; D014807:Vitamin D