title: Evaluating the effect of risperidone on speech: A cross-sectional study.
abstract: Speech subsystems are susceptible to the effects of several factors including medications. The atypical antipsychotics can also adversely affect the speech because of its action on serotonin and dopamine neurotransmitters. The present study aims to analyze the speech characteristics associated with atypical antipsychotic risperidone. Speech of 92 patients on risperidone with or without trihexyphenidyl and/or clonazepam were compared with that of 31 persons who were not on any psychotropic medicines. Compared to control group, maximum phonation duration, sequential motion rate of diadochokinesia was reduced by about 3s and 1syllable/s respectively and s/z ratio was increased by 0.16 in patients with risperidone. Performance of larynx, lips and tongue sub-system and intelligibility of speech were also significantly reduced in risperidone group. Risperidone did impact the phonation and articulation sub-systems of speech mildly, which was independent of tardive dyskinesia and extrapyramidal symptoms. Randomized controlled prospective study looking into impact on speech and related effect on drug adherence, functioning and quality of life needs to be conducted with risperidone and other atypical antipsychotics.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: drpreetisinha@gmail.com.
authors.forename: Preeti
authors.initials: P
authors.lastname: Sinha
authors.affiliation: Department of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: vpvandana@gmail.com.
authors.forename: V P
authors.initials: VP
authors.lastname: Vandana
authors.affiliation: Department of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: nikkivlewis@gmail.com.
authors.forename: Nikita Vincent
authors.initials: NV
authors.lastname: Lewis
authors.affiliation: Department of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India. Electronic address: jayaram@nimhans.kar.nic.in.
authors.forename: M
authors.initials: M
authors.lastname: Jayaram
authors.affiliation: The Innovation Centre, 217 Portobello, Sheffield S1 4DP, UK. Electronic address: p.m.enderby@sheffield.ac.uk.
authors.forename: Pamela
authors.initials: P
authors.lastname: Enderby
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018967:Risperidone / Q000009:adverse effects*; D013060:Speech / Q000187:drug effects*; D013064:Speech Disorders / Q000139:chemically induced; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone
keywords: Adverse-effects; Articulation; Atypical antipsychotics; Phonation; Risperidone; Speech