title: Nuclear envelope and chromatin, lock and key of genome integrity.
abstract: More than as an inert separation between the inside and outside of the nucleus, the nuclear envelope (NE) constitutes an active toll, which controls the import and export of molecules, and also a hub for a diversity of genomic processes, such as transcription, DNA repair, and chromatin dynamics. Proteins localized at the inner surface of the NE (such as lamins, nuclear pore proteins, lamin-associated proteins) interact with chromatin in a dynamic manner, contributing to the establishment of topological domains. In this review, we address the complex interplay between chromatin and NE. We discuss the divergence of this cross talk during evolution and comment both on the current established models and the most recent findings. In particular, we focus our attention on how the NE cooperates with chromatin in protecting the genome integrity.
authors.affiliation: IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy.
authors.forename: Sophie
authors.initials: S
authors.lastname: Gay
authors.affiliation: IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Foiani
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D002843:Chromatin / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D009685:Nuclear Envelope / Q000235:genetics*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism
chemical_list: D002843:Chromatin; D028861:Nuclear Pore Complex Proteins
keywords: Chromatin; DNA metabolism; Genome stability; Histone modifications; Lamin; Nuclear envelope; Nuclear pore complex