title: Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release.
abstract: We designed poly(β-amino esters) (PBAEs) bearing both UV light- and pH-sensitive groups and used PBAEs to prepare nanoparticles (NPs) that can be utilized for on-demand burst release of guest molecules in response to multiple triggers. Due to the presence of the photo-cleavable group in each repeating unit of PBAE, rapid release of encapsulated model drug could be achieved even with exposures to low intensity UV (10 mW · cm(-2) ). Especially, the burst release was further accelerated by additional UV treatments in the acidic condition showing the combinatory effect of dual stimuli. We believe these PBAE-based NPs can potentially be used to design intelligent controlled release device and nanomedicines.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801, USA. jungseok.lee78@gmail.com.|Department of Biomedical Engineering, Yale University, 55 Prospect Street, New Haven, Connecticut 06520, USA. jungseok.lee78@gmail.com.
authors.forename: Jung Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801, USA.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Biomedical Engineering, Yale University, 55 Prospect Street, New Haven, Connecticut 06520, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Han
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 West Green Street, Urbana, Illinois 61801, USA. jianjunc@illinois.edu.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D011108:Polymers; C507253:poly(beta-amino ester)
keywords: UV-sensitive; nanomedicine; on-demand release; pH-sensitive; poly(β-amino ester)