title: Prostate tumor specific peptide-peptoid hybrid prodrugs.
abstract: Inspired by naturally occurring host defense peptides, cationic amphipathic peptoids provide a promising scaffold for anti-cancer therapeutics. Herein, we report a library of peptide-peptoid hybrid prodrugs that can be selectively activated by prostate cancer cells. We have identified several compounds demonstrating potent anti-cancer activity with good to moderate selectivity. We believe that these prodrugs can provide a useful design principle for next generation peptide-peptoid hybrid prodrugs.
authors.affiliation: Department of Global Medical Science, Sungshin University, Seoul 142-732, Republic of Korea.
authors.forename: Jiyoun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Broering
authors.affiliation: Department of Bioengineering, Stanford University, Palo Alto, CA 94305, USA. Electronic address: aebarron@stanford.edu.
authors.forename: Annelise E
authors.initials: AE
authors.lastname: Barron
authors.affiliation: Division of Liberal Arts and Sciences and Department of Chemistry, Gwangju Institute of Science and Technology, 123 Cheomdan gwagiro, Buk-gu, Gwangju 500-712, Republic of Korea. Electronic address: jseo@gist.ac.kr.
authors.forename: Jiwon
authors.initials: J
authors.lastname: Seo
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008297:Male; D010455:Peptides / Q000737:chemistry*; D057786:Peptidomimetics; D034444:Peptoids / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D057786:Peptidomimetics; D034444:Peptoids; D011355:Prodrugs
keywords: Anti-cancer; Antimicrobial peptides; Peptidomimetics; Peptoids; Prodrug; Prostate cancer