title: Methotrexate-associated Lymphoproliferative Disease with Multiple Pulmonary Nodules in a Patient with Rheumatoid Arthritis.
abstract: Patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) sometimes develop lymphoproliferative disease (LPD). MTX-associated LPD can affect nodal or extranodal sites, including the gastrointestinal tract, skin, lungs, kidneys and soft tissues, at almost equal frequency. However, it is very rare for MTX-associated LPD to manifest as multiple nodules in the lungs. We herein report the case of a RA patient who developed MTX-associated LPD with multiple pulmonary nodules during a 5-year course of MTX therapy.
authors.affiliation: Department of Hematology, Clinical Immunology and Infectious Disease, Ehime University Graduate School of Medicine, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Suemori
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Jun
authors.initials: J
authors.lastname: Ishizaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Sachiko
authors.initials: S
authors.lastname: Onishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Sada
authors.forename: Atsuro
authors.initials: A
authors.lastname: Sugita
authors.forename: Masaki
authors.initials: M
authors.lastname: Yasukawa
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008232:Lymphoproliferative Disorders / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D055613:Multiple Pulmonary Nodules / Q000139:chemically induced*
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate