title: Factors That Predict the Development of Hypertension in Women With Pregnancy-Induced Hypertension.
abstract: BACKGROUND
  Pregnancy-induced hypertension (PIH) is associated with chronic hypertension (HTN) and cardiovascular complications. We investigated the factors that predict the development of chronic HTN in women with PIH.
  
  
  METHODS
  The study population comprised 108 women with PIH and 87 healthy age-matched women control subjects who gave birth during the years 1990-1994 at the Chaim Sheba Medical Center, Israel, and were followed for up to 23 years (average 20.8 ± 1.4). We analyzed the association between PIH and subsequent HTN and cardiovascular complications, aiming to identify predicting factors for the development of chronic HTN in this subject population.
  
  
  RESULTS
  At the time of index pregnancy, women with PIH were more likely to be overweight, had elevated blood pressure (BP) levels, a shorter gestational period, required more cesarean sections, and were more likely to deliver small infants than the control group. Compared to women with normotensive pregnancy, women with PIH had 11-fold higher age-adjusted risk of developing HTN. They also had a higher body mass index (BMI), and were more likely to develop diabetes mellitus (DM) and coronary artery disease, during follow-up. Among women with PIH, those subjects who developed HTN were older during pregnancy, had higher BMI and more deliveries before the index pregnancy.
  
  
  CONCLUSIONS
  Our findings confirm the association between PIH and chronic HTN. In women with PIH, high BMI and more previous pregnancies are risk factors for developing HTN. Thus, obese women with multiple pregnancies who develop PIH should be more closely followed for the development of HTN.
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;
authors.forename: Noa
authors.initials: N
authors.lastname: Shopen
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer, Israel;
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;
authors.forename: Nira
authors.initials: N
authors.lastname: Koren-Morag
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Internal Medicine D and Hypertension Unit, The Chaim Sheba Medical Center, Tel-Hashomer, Israel. grosse@post.tau.ac.il.
authors.forename: Ehud
authors.initials: E
authors.lastname: Grossman
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D005544:Forecasting; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology* / Q000503:physiopathology; D007557:Israel / Q000453:epidemiology; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
keywords: blood pressure; hypertension; multiple pregnancies; obesity; pregnancy-induced hypertension.