title: Increasing the Number of Organ Transplants in the United States by Optimizing Donor Authorization Rates.
abstract: While recent policies have focused on allocating organs to patients most in need and lessening geographic disparities, the only mechanism to increase the actual number of transplants is to maximize the potential organ supply. We conducted a retrospective cohort study using OPTN data on all "eligible deaths" from 1/1/08 to 11/1/13 to evaluate variability in donor service area (DSA)-level donor authorization rates, and to quantify the potential gains associated with increasing authorization rates. Despite adjustments for donor demographics (age, race/ethnicity, cause of death) and geographic factors (rural/urban status of donor hospital, statewide participation in deceased-donor registries) among 52 571 eligible deaths, there was significant variability (p < 0.001) in donor authorization rates across the 58 DSAs. Overall DSA-level adjusted authorization rates ranged from 63.5% to 89.5% (median: 72.7%). An additional 773-1623 eligible deaths could have been authorized, yielding 2679-5710 total organs, if the DSAs with authorization rates below the median and 75th percentile, respectively, implemented interventions to perform at the level of the corresponding reference DSA. Opportunities exist within the current organ acquisition framework to markedly improve DSA-level donor authorization rates. Such initiatives would mitigate waitlist mortality while increasing the number of transplants.
authors.affiliation: Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.|Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.|Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
authors.forename: D S
authors.initials: DS
authors.lastname: Goldberg
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.|Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
authors.forename: B
authors.initials: B
authors.lastname: French
authors.affiliation: Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
authors.forename: P L
authors.initials: PL
authors.lastname: Abt
authors.affiliation: Center for Transplantation and Department of Medicine, University of Kansas Medical Center, Kansas City, KS.
authors.forename: R K
authors.initials: RK
authors.lastname: Gilroy
mesh_terms: D006801:Humans; D016377:Organ Transplantation / Q000706:statistics & numerical data*; D014019:Tissue Donors
keywords: donors and donation; donors and donation: donation after brain death (DBD); organ procurement; organ procurement organization