title: Synthesis and in vitro Screening of 29, 30-Dibromo-28-oxoallobetulin against Parasitic Protozoans, Leishmania donovani and Leishmania Major.
abstract: A simple synthesis and in vitro antileishmanial activity of 29,30-dibromo-28-oxoallobetulin against the parasitic protozoans, Leishmania donovani and Leishmania major is described. The structure of the compound is established on the basis of spectral data (IR, NMR, MS). Both the antiproliferative effect and the cell cycle progression were studied.
authors.affiliation: Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammhunpur, Darjeeling-734 013, India.
authors.forename: P
authors.initials: P
authors.lastname: Ghosh
authors.affiliation: Natural Products and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Raja Rammhunpur, Darjeeling-734 013, India.
authors.forename: A
authors.initials: A
authors.lastname: Mandal
authors.affiliation: Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat-700 126, India.
authors.forename: S
authors.initials: S
authors.lastname: Dey
authors.affiliation: Cellular Immunology and Experimental Therapeutics Laboratory, Department of Zoology, West Bengal State University, Barasat-700 126, India.
authors.forename: C
authors.initials: C
authors.lastname: Pal
keywords: Triterpenoid; antiproliferative; halogen; leishmania