title: Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin.
abstract: The mammalian hypothalamic magnocellular neurons of the supraoptic and paraventricular nuclei are among the best understood of all peptidergic neurons. Through their anatomical features, vasopressin- and oxytocin-containing neurons have revealed many important aspects of dendritic functions. Here, we review our understanding of the mechanisms of somato-dendritic peptide release, and the effects of autocrine, paracrine and hormone-like signalling on neuronal networks and behaviour.
authors.affiliation: Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK mike.ludwig@ed.ac.uk.
authors.forename: Mike
authors.initials: M
authors.lastname: Ludwig
authors.affiliation: Department of Physiology, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
authors.forename: Javier
authors.initials: J
authors.lastname: Stern
mesh_terms: D002450:Cell Communication / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007031:Hypothalamus / Q000166:cytology* / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D010121:Oxytocin / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D010121:Oxytocin
keywords: calcium; homeostasis; hypothalamus; paraventricular nucleus; priming; supraoptic nucleus