title: Gender Influence on Long-Term Weight Loss and Comorbidities After Laparoscopic Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: a Prospective Study With a 5-Year Follow-up.
abstract: BACKGROUND
  Gender might be important in predicting outcomes after bariatric surgery. The aim of the study was to investigate the influence of gender on long-term weight loss and comorbidity improvement after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).
  
  
  METHODS
  A cohort of 304 consecutive patients underwent surgery in 2006-2009: 162 (98 women, 64 men) underwent LSG and 142 (112 women, 30 men) underwent LRYGB. The mean follow-up time was 75.8 ± 8.4 months (range, 60-96 months).
  
  
  RESULTS
  Overall mean (95% CI) reduction in BMI was 23.5 (24.3-22.7) kg/m(2) after 5 years, with no statistical difference between LSG and LRYGB groups (P = 0.94). The overall means ± standard deviations of %EBMIL after 5 years were 78.8 ± 23.5 and 81.6 ± 21.4 in the LSG and LRYGB groups, respectively. Only for LSG group %EBMIL after 24-36 and 60 months differed significantly between male and female patients (P = 0.003 versus P = 0.06 in LRYGB), and 89 versus 90% of patients showed improvements in comorbidities in the LSG and LRYGB groups, respectively. Only two patients (women) were lost to follow-up: 1/162 (0.6%) for LSG at the 4th year and 1/142 (0.7%) for LRYGB to the 5th year.
  
  
  CONCLUSIONS
  LSG was more effective in obese male than in female patients in terms of %EBMIL, with no difference in comorbidities. LRYGB elicited similar results in both genders in terms of %EBMIL and comorbidities.
authors.affiliation: General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. fed.perrone@gmail.com.
authors.forename: Federico
authors.initials: F
authors.lastname: Perrone
authors.affiliation: Psychiatric Unit, Department of System Medicine, University of Rome, Tor Vergata, Italy. emanuelabianciardi@libero.it.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Bianciardi
authors.affiliation: General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. dobenavoli@yahoo.com.
authors.forename: Domenico
authors.initials: D
authors.lastname: Benavoli
authors.affiliation: General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. vtognoni@gmail.com.
authors.forename: Valeria
authors.initials: V
authors.lastname: Tognoni
authors.affiliation: Psychiatric Unit, Department of System Medicine, University of Rome, Tor Vergata, Italy. niolu@med.uniroma2.it.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Niolu
authors.affiliation: Psychiatric Unit, Department of System Medicine, University of Rome, Tor Vergata, Italy. siracusano@med.uniroma2.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Siracusano
authors.affiliation: General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. gaspari@med.uniroma2.it.
authors.forename: Achille L
authors.initials: AL
authors.lastname: Gaspari
authors.affiliation: General Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. gentilp@yahoo.com.|Bariatric Surgery Unit, Department of Experimental Medicine and Surgery, University of Rome, Tor Vergata, Italy. gentilp@yahoo.com.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gentileschi
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000706:statistics & numerical data*; D015390:Gastric Bypass / Q000706:statistics & numerical data*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000601:surgery*; D011446:Prospective Studies; D012737:Sex Factors; D015431:Weight Loss
keywords: Bariatric surgery; Gastric Bypass; Gender; Obesity; Predictors; Sleeve gastrectomy; Weight loss