title: Lympho-vascular space invasion indicates advanced disease for uterine papillary serous tumors arising from polyps.
abstract: BACKGROUND
  Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was to evaluate uterine papillary serous tumors arising from polyps.
  
  
  METHODS
  Clinicopathological data of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively.
  
  
  RESULTS
  We analyzed patients according to FIGO 2009 staging system as stage 1A and higher than stage 1A (3 and 6, respectively). All the patients were postmenopausal. Mean CA-125, CA-19.9 and CA15.3 levels were elevated in higher than stage 1A group. However we did not find a statistical difference between age, parity, polyp size, CA-125, CA-15.3, CA-19.9 and CEA levels. Lympho-vascular space invasion (LVSI) showed predictivity for advanced disease (p=0.025).
  
  
  CONCLUSIONS
  The histopathologic nature of uterine serous carcinoma is a unique entity. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor.
authors.affiliation: Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey E-mail : ilkerselcukmd@hotmail.com.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ilker
authors.forename: Korkmaz
authors.initials: K
authors.lastname: Elmas
authors.forename: Ozgu
authors.initials: O
authors.lastname: Emre
authors.forename: Turker
authors.initials: T
authors.lastname: Mengu
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.forename: Gungor
authors.initials: G
authors.lastname: Tayfun
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001808:Blood Vessels / Q000473:pathology*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002291:Carcinoma, Papillary / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000473:pathology*; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009215:Myometrium / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011127:Polyps / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D018396:Mucin-1