title: Late-Stage Peptide Diversification by Bioorthogonal Catalytic C-H Arylation at 23 °C in H2 O.
abstract: The step-economical late-stage diversification of tryptophan-containing peptides was accomplished through chemo- and site-selective palladium-catalyzed C-H arylation under exceedingly mild reaction conditions. Thus, the C-H functionalization occurred efficiently at 23 °C with a catalyst loading as low as 0.5 mol %, and/or in H2 O.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammanstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammanstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/
authors.forename: Michaela
authors.initials: M
authors.lastname: Bauer
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammanstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/. lutz.ackermann@chemie.uni-goettingen.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
mesh_terms: D002384:Catalysis; D006860:Hydrogen Bonding; D010165:Palladium / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D013696:Temperature; D014364:Tryptophan / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D010455:Peptides; D014867:Water; D010165:Palladium; D014364:Tryptophan
keywords: CH activation; H2O; chemoselectivity; late-stage derivatization; peptides