title: Actin-filament disassembly: it takes two to shrink them fast.
abstract: Actin-filament disassembly is indispensable for replenishing the pool of polymerizable actin and allows continuous dynamic remodelling of the actin cytoskeleton. A new study now reveals that ADF/cofilin preferentially dismantles branched networks and provides new insights into the collaborative work of ADF/cofilin and Aip1 on filament disassembly at the molecular level.
authors.affiliation: Institute for Biophysical Chemistry, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Winterhoff
authors.affiliation: Institute for Biophysical Chemistry, Hannover Medical School, Carl-Neuberg Str. 1, 30625 Hannover, Germany. Electronic address: faix.jan@mh-hannover.de.
authors.forename: Jan
authors.initials: J
authors.lastname: Faix
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D051339:Actin Depolymerizing Factors / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism*
chemical_list: D051339:Actin Depolymerizing Factors; D008840:Microfilament Proteins; C115237:actin interacting protein 1