title: Corpus callosum involvement and postoperative outcomes of patients with gliomas.
abstract: Corpus callosum involvement is associated with poorer survival in high grade glioma (HGG), but the prognostic value in low grade glioma (LGG) is unclear. To determine the prognostic impact of corpus callosum involvement on progression free survival (PFS) and overall survival (OS) in HGG and LGG, the records of 233 glioma patients treated from 2008 to 2011 were retrospectively reviewed. Preoperative magnetic resonance (MR) images were used to identify corpus callosum involvement. Age, sex, preoperative Karnofsky performance scale, postoperative Eastern Cooperative Oncology Group (ECOG) score and extent of resection (EOR) were evaluated with respect to PFS and OS. The incidence of corpus callosum involvement was similar among HGG (14 %) and LGG (14.5 %). Univariate analysis revealed that PFS and OS were significantly shorter in both WHO grade II and grade IV glioma with corpus callosum involvement (both, p < 0.05). Multivariate analysis showed that grade II glioma with corpus callosum involvement have shorter PFS (p = 0.03), while EOR, instead of corpus callosum involvement (p = 0.16), was an independent factor associated with PFS in grade IV glioma (p < 0.05). Corpus callosum involvement was no longer significantly associated with OS after adjusting age, gender, EOR, preoperative and postoperative performance status (p = 0.16, 0.17 and 0.56 in grade II, III and IV gliomas, respectively). Corpus callosum involvement happened in both LGG and HGG, and is associated with lower EOR and higher postoperative ECOG score both in LGG and HGG. Corpus callosum involvement tends to be an independent prognostic factor for PFS in LGG, but not for OS in LGG or in HGG.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
authors.forename: Ko-Ting
authors.initials: KT
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.
authors.forename: Tai-Wei Erich
authors.initials: TW
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Chuang
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Yung-Hsin
authors.initials: YH
authors.lastname: Hsu
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Peng-Wei
authors.initials: PW
authors.lastname: Hsu
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Yin-Cheng
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Tzu-Kang
authors.initials: TK
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chen-Nen
authors.initials: CN
authors.lastname: Chang
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Shih-Tseng
authors.initials: ST
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chieh-Tsai
authors.initials: CT
authors.lastname: Wu
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Chang-Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chen-Kan
authors.initials: CK
authors.lastname: Tseng
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Chang-Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Chun-Chieh
authors.initials: CC
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Chang-Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Ping-Ching
authors.initials: PC
authors.lastname: Pai
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Wei
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC. pinyuanc@gmail.com.|School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC. pinyuanc@gmail.com.
authors.forename: Pin-Yuan
authors.initials: PY
authors.lastname: Chen
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D053208:Kaplan-Meier Estimate; D017567:Karnofsky Performance Status; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Corpus callosum; Extent of resection (EOR); Glioma; Overall survival (OS); Progression free survival (PFS)