title: Where is the radiobiology and pharmacology research to improve outcomes in glioblastoma?
abstract: Personalized medicine has been helpful for drug development in diseases with single and relatively stable gene mutations. The benefit for complex solid tumours with heterogeneous and changing genetic profiles is less clear. Whether it is efficient to continue diverting resources from combined biological and pharmacological approaches to trial new and existing genetic 'targeted therapies' for brain tumours is unknown but of developing concern in resource constrained environments.
authors.affiliation: Department of Radiation Oncology, Calvary Mater Hospital, Waratah, New South Wales, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Fay
authors.forename: Richard
authors.initials: R
authors.lastname: Head
authors.forename: Jennifer
authors.initials: J
authors.lastname: Martin
mesh_terms: D005909:Glioblastoma / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D033183:Interdisciplinary Communication; D016896:Treatment Outcome