title: Serotonin: A New Hope in Alzheimer's Disease?
abstract: Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.
authors.affiliation: †CNRS, UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.|‡Inserm, U1191, F-34000 Montpellier, France.|§Université de Montpellier, UMR-5203, F-34000 Montpellier, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Claeysen
authors.affiliation: †CNRS, UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.|‡Inserm, U1191, F-34000 Montpellier, France.|§Université de Montpellier, UMR-5203, F-34000 Montpellier, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaert
authors.affiliation: †CNRS, UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France.|‡Inserm, U1191, F-34000 Montpellier, France.|§Université de Montpellier, UMR-5203, F-34000 Montpellier, France.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Giannoni
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism* / Q000517:prevention & control; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000378:metabolism; D044422:Receptors, Serotonin, 5-HT4 / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D058828:Serotonin 5-HT4 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016564:Amyloid beta-Protein Precursor; D018697:Nootropic Agents; D011985:Receptors, Serotonin; D044422:Receptors, Serotonin, 5-HT4; D012701:Serotonin; D058828:Serotonin 5-HT4 Receptor Agonists; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; C545487:APP protein, human; C097216:serotonin 6 receptor
keywords: 5-HT4 receptors; 5-HT6 receptors; Serotonin; neuroprotection