title: [Isotretinoin and depressive symptoms in patiens with severe and recurrent acne].
abstract: BACKGROUND
  Since use of isotretinoin for acne management it has been published controversial results about its association with depression. The objective of this study was to know if use of isotretinoin in patients with severe and recurrent acne (SRA) is associated with depression.
  
  
  METHODS
  22 patients with diagnosis of SRA were included from the National Medical Center La Raza's Acne Clinic. They completed the Beck Depression inventory (IDB-II) before, during (2 months) and after treatment with isotretinoin (4 months), calculated at 0.5 mg/kg.
  
  
  RESULTS
  The patients reported low depressive symptoms before treatment that reduced at the end (median=6 and 0, respectively, p<0.001).
  
  
  CONCLUSIONS
  Treatment with isotretinoin in this sample of patients with severe and recurrent acne produced no increase in depressive symptoms, but improvement, due to the best corporal image self-perception.
authors.affiliation: Departamento de Dermatología, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal. tisharubg@yahoo.com.
authors.forename: Leticia
authors.initials: L
authors.lastname: Rubio-García
authors.forename: Nancy
authors.initials: N
authors.lastname: Pulido-Díaz
authors.forename: José Luis
authors.initials: JL
authors.lastname: Jímenez-López
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000523:psychology; D000293:Adolescent; D000328:Adult; D003863:Depression / Q000139:chemically induced* / Q000175:diagnosis; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin
keywords: Acne; Depressive symptoms; Isotretinoin