title: Altered local field potential activity and serotonergic neurotransmission are further characteristics of the Flinders sensitive line rat model of depression.
abstract: A significant portion of patients suffering from major depression remains refractory to available antidepressant treatment strategies. This highlights the need for a better understanding of the underlying neuropathology in order to develop rationale-based treatments. Here we aimed to further characterize neurobiological abnormalities of the Flinders Sensitive Line (FSL) rat model of depression. Biochemically, in FSL rats we mainly found increased levels of serotonin in most cortical and subcortical brain regions when compared to controls. Using electrophysiological measurements, in FSL rats we found decreased alpha, beta and low gamma oscillatory activity in the medial prefrontal cortex and nucleus accumbens and decreased alpha and beta as well as increased low gamma oscillatory activity in the subthalamicus nucleus when compared to controls. In summary, we show distinct neurochemical properties in combination with particular oscillatory activity patterns for brain areas thought to be pathophysiologically relevant for depression. Our data contribute to the further understanding of neurobiological alterations in the FSL rat model of depression that could provide a basis for research into future therapeutic strategies.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Voget
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Rummel
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Avchalumov
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Sohr
authors.affiliation: Department of Neurology, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Jens K
authors.initials: JK
authors.lastname: Haumesser
authors.affiliation: International Graduate Program Medical Neurosciences, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Ellis
authors.initials: E
authors.lastname: Rea
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Aleksander A
authors.initials: AA
authors.lastname: Mathé
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Ravit
authors.initials: R
authors.lastname: Hadar
authors.affiliation: Department of Neurology, Charité Universitätsmedizin Berlin, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: van Riesen
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address: christine.winter@uniklinikum-dresden.de.
authors.forename: Christine
authors.initials: C
authors.lastname: Winter
mesh_terms: D000513:Alpha Rhythm; D000818:Animals; D001611:Beta Rhythm; D001921:Brain / Q000503:physiopathology*; D003866:Depressive Disorder / Q000503:physiopathology*; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D065818:Gamma Rhythm; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013045:Species Specificity; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
keywords: Flinders sensitive line rats; Local field potentials; Major depression; Serotonin