title: Management of brain metastasis in a patient with advanced epithelial ovarian carcinoma by gamma-knife radiosurgery.
abstract: BACKGROUND
  Brain metastases from epithelial ovarian cancer (EOC) are rare events. We present a rare case of single ovarian cancer metastasis to the brain treated with gamma-knife radiosurgery (GKRS).
  
  
  METHODS
  A 65-year-old woman with advanced EOC presented with severe neurologic symptoms. A single brain metastasis of 3.2 cm with surrounding edema in the left parietal lobe was detected by brain magnetic resonance imaging (MRI) scan during the work-up. The decision to perform GKRS was due to a surgical inaccessibility of intracranial lesion. Twelve weeks after the procedure, the MRI scan showed reduction in the diameter of brain metastasis and surrounding edema and the patient returned to good mental and motor performance.The patient survived for 22 months following treatment and died from a progressive intra-abdominal disease. Prognosis of ovarian cancer patients with brain metastases is generally poor regardless of treatment.
  
  
  CONCLUSIONS
  Our case shows that GKRS as primary treatment modality for the control of ovarian cancer metastases to the brain was effective and can be considered as a treatment of choice if international selection criteria are followed.
authors.forename: Marinos
authors.initials: M
authors.lastname: Nikolaoul
authors.forename: Srdjan
authors.initials: S
authors.lastname: Stamenković
authors.forename: Christos
authors.initials: C
authors.lastname: Stergiou
authors.forename: Christos
authors.initials: C
authors.lastname: Skarleas
authors.forename: Michael
authors.initials: M
authors.lastname: Torrens
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D000077216:Carcinoma, Ovarian Epithelial; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016634:Radiosurgery / Q000295:instrumentation*