title: Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.
abstract: BACKGROUND
  We conducted a genomewide association study (GWAS) for maximum number of alcoholic drinks consumed in a 24-hour period ("MaxDrinks"), in 2 independent samples comprised of over 9,500 subjects, following up on our GWAS for alcohol dependence (AD) in European Americans (EAs) and African Americans (AAs).
  
  
  METHODS
  The samples included our GWAS samples (Yale-UPenn) recruited for studies of the genetics of drug or AD, and a publicly available sample: the Study of Addiction: Genetics and Environment (SAGE). Genomewide association analysis was performed for ~890,000 single nucleotide polymorphisms (SNPs) using linear association random effects models. EAs and AAs were separately analyzed.
  
  
  RESULTS
  The results confirmed significant associations of the well-known functional loci at ADH1B with MaxDrinks in EAs (rs1229984 Arg48His p = 5.96 × 10(-15) ) and AAs (rs2066702 Arg370Cys, p = 2.50 × 10(-10) ). The region of significant association on chromosome 4 was extended to LOC100507053 in AAs but not EAs. We also identified potentially novel significant common SNPs for MaxDrinks in EAs in the Yale-UPenn sample: rs1799876 at SERPINC1 on chromosome 1 (4.00 × 10(-8) ) and rs2309169 close to ANKRD36 on chromosome 2 (p = 5.58 × 10(-9) ). After adjusting for the peak SNP rs1229984 on ADH1B, rs1799876 was nearly significant (p = 1.99 × 10(-7) ) and rs2309169 remained highly significant (2.12 × 10(-9) ).
  
  
  CONCLUSIONS
  The results provide further support that ADH1B modulates alcohol consumption. Future replications of potential novel loci are warranted. This is the largest MaxDrinks GWAS to date, the first in AAs.
authors.affiliation: Department of Psychiatry, Yale School of Medicine, and VA CT Healthcare Center, West Haven, Connecticut.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and VISN 4 MIRECC, Philadelphia VA Medical Center, Philadelphia, Pennsylvania.
authors.forename: Henry R
authors.initials: HR
authors.lastname: Kranzler
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Richard
authors.initials: R
authors.lastname: Sherva
authors.affiliation: Department of Psychiatry, Yale School of Medicine, and VA CT Healthcare Center, West Haven, Connecticut.
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Sartor
authors.affiliation: Department of Psychiatry, Texas Biomedical Research Institute, San Antonio, Texas.
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Ryan
authors.initials: R
authors.lastname: Koesterer
authors.affiliation: Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Farrer
authors.affiliation: Department of Psychiatry, Yale School of Medicine, and VA CT Healthcare Center, West Haven, Connecticut.|Department of Genetics and Neurobiology, Yale University School of Medicine, West Haven, Connecticut.
authors.forename: Joel
authors.initials: J
authors.lastname: Gelernter
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data*; D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000428:Alcohol Drinking / Q000208:ethnology / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D044465:White People / Q000706:statistics & numerical data*
chemical_list: C489332:ADH1B protein, human; D000426:Alcohol Dehydrogenase
keywords: African American; Alcohol Maximum Drinks; European American; Genomewide Association