title: Correlation between polymorphisms in DNA mismatch repair genes and the risk of primary hepatocellular carcinoma for the Han population in northern China.
abstract: OBJECTIVE
  This study investigated correlations between polymorphisms in DNA mismatch repair (MMR) genes and the risk of primary hepatocellular carcinoma (PHC).
  
  
  METHODS
  Single nucleotide polymorphisms (SNPs) in the DNA MMR genes MLH3 (rs175080), PMS1 (rs5742933), PMS2 (rs1059060), MSH3 (rs26279), MSH5 (rs1150793, rs2075789) and MSH6 (rs1042821) were detected using the SNaPshot method in 250 PHC cases and in 308 patients without PHC in the Han population in northern China.
  
  
  RESULTS
  The AA genotype in MLH3 (rs175080) increased the risk of PHC (odds ratio [OR] = 3.424; 95% confidence interval [CI]: 1.097-10.689). The AG and GG genotypes in MSH3 (rs26279) increased the risk of PHC (OR: 1.644 and 3.300; 95% CI: 1.112-2.428 and 1.765-6.168, respectively). The AA genotype in MSH5 (rs2075789) increased the risk of PHC (OR: 9.229; 95% CI: 1.174-72.535). The CT genotype in MSH6 (rs1042821) reduced the risk of PHC (OR: 0.629; 95% CI: 0.428-0.924).
  
  
  CONCLUSIONS
  Our study suggests that polymorphisms in MLH3 (rs175080), MSH3 (rs26279), MSH5 (rs2075789) and MSH6 (rs1042821) may be independent risk factors for PHC.
authors.affiliation: Department of Epidemiology and Statistics, Hebei Medical University , Shi Jiazhuang , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.forename: Jinhai
authors.initials: J
authors.lastname: Jia
authors.forename: Longmei
authors.initials: L
authors.lastname: Tang
authors.forename: Xia
authors.initials: X
authors.lastname: Gao
authors.forename: Lina
authors.initials: L
authors.lastname: Yan
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
authors.forename: Fengxue
authors.initials: F
authors.lastname: Yu
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Wenxuan
authors.initials: W
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Yang
authors.forename: Xuehui
authors.initials: X
authors.lastname: Liu
authors.forename: Dianwu
authors.initials: D
authors.lastname: Liu
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D053843:DNA Mismatch Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: DNA mismatch repair gene; primary hepatocellular carcinoma; single nucleotide polymorphism