title: Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata.
abstract: OBJECTIVE
  To investigate the distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G) and IL-23 receptor (IL23R; +2199A/C) gene polymorphisms in patients with alopecia areata.
  
  
  METHODS
  Patients with alopecia areata and healthy controls were enrolled in this case-control study. Genotyping of the IL12 (1188A/C), IL17 (A7488G) and IL23R (+2199A/C) polymorphisms was undertaken. Genotype frequencies were compared between the two groups.
  
  
  RESULTS
  The study enrolled 100 patients with alopecia areata and 71 control subjects. No significant differences were found in the frequencies for the IL12 and IL23R gene polymorphisms between the patient and control groups. The IL17 GG genotype was significantly more common and the IL17 GA genotype was significantly less common in patients with alopecia areata compared with controls, but only 10% of patients had the GG genotype.
  
  
  CONCLUSIONS
  The IL17 GG genotype was associated with susceptibility for alopecia areata, but this genotype was only present in a small number of patients. The IL12 and IL23R gene polymorphisms were not found to have a significant association with alopecia areata.
authors.affiliation: Department of Dermatology, Merzifon Kara Mustafa Pasa Hospital, Samsun, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Aytekin
authors.affiliation: Department of Dermatology, Medical School, Gaziantep University, Gaziantep, Turkey.
authors.forename: Cenk
authors.initials: C
authors.lastname: Akcali
authors.affiliation: Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.affiliation: Department of Dermatology, Medical School, Gaziantep University, Gaziantep, Turkey.
authors.forename: Necmettin
authors.initials: N
authors.lastname: Kirtak
authors.affiliation: Department of Dermatology, Medical School, Gaziantep University, Gaziantep, Turkey inalozhs@gmail.com.
authors.forename: Serhat
authors.initials: S
authors.lastname: Inaloz
mesh_terms: D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D055815:Young Adult
chemical_list: C508717:IL17A protein, human; C515500:IL23R protein, human; D020381:Interleukin-17; D018123:Receptors, Interleukin; D018664:Interleukin-12
keywords: Alopecia areata; interleukin-12; interleukin-17; interleukin-23 receptor; polymorphism