title: Dynamic Layer-by-Layer Films: A Platform for Zero-Order Release.
abstract: Zero-order release is the ultimate goal of controlled drug release systems, however, it still remains a big challenge despite of numerous previous efforts. Here we show that the release of P(AAm-3-AAPBA) from P(AAm-3-AAPBA)/PVA film, a dynamic layer-by-layer (LBL) film, follows a perfect zero-order kinetics, provided that both polymers in the film have a narrow molecular weight distribution. Instead of releasing via diffusion or degradation, P(AAm-3-AAPBA) is released from the film via the dissociation of the interpolymer complex. The release rate is determined by molecular weight of the polymers. One could also tune the release rate via various external environmental stimuli, including pH, temperature, and glucose. The results suggest dynamic LBL film could serve as a new drug release platform that allows for not only zero-order release, but also intelligent release.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors.forename: Qingping
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guan
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D001897:Boronic Acids / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D008970:Molecular Weight
chemical_list: C419826:3-acrylamidophenylboronic acid; D001672:Biocompatible Materials; D001897:Boronic Acids; D003692:Delayed-Action Preparations