title: [The inversion of concepts about biological role of system rennin-angiotensin II- aldosterone and functions of arterial tension as a metabolism regulator].
abstract: The phylogenetic theory of general pathology postulates that in physiology and pathology the concepts of biological role of arterial tension had been subjected to inversion. The activation by nephron of synthesis of components rennin-angiotensin II and increasing of aldosterone secretion are directed not to increase arterial tension but to preserve volume of piece of third world ocean privatized by each entity as pool of intercellular medium where all cells continue to live as billions years before. In phylogenetic sense, early organs can't regulate effect of physical factor of regulation of metabolism the late one in phylogenesis of arterial tension. The cause of increasing of arterial tension is the vasomotor center but not the kidneys. The vasomotor center increases arterial tension in the proximal section and further hydrodynamic tension in the distal section of arterial stream and tends to resuscitate function of nephrons, biological function of endoecology and biological reaction of excretion. The arterial tension, besides the main role in biological function of locomotion, is a physical factor of compensation of disorders of biological functions of homeostasis, trophology, endoecology and adaptation. In phylogenesis, three levels of metabolism regulation has been developed The specific regulation of biochemical reactions occurs on autocrine level. In paracrin regulated cell cenosises, at distal section of arterial stream, metabolism is regulated by billions of local peristaltic pumps through compensation of biological reaction of endothelium-depended vasodilatation, micro-circulation, effect of humoral mediators and hormonal principles. In vivo, from the level of vasomotor center, metabolism non-specifically and systemic regulates physical factor-arterial tension through sympathetic activation of heart. The arterial tension in proximal section of arterial stream overcomes resistance and physically "forces through" arterioles with disordered micro-circulation. The angiotensin II is a vasoconstrictor only in distal section of arterial stream. In the process of pathogenesis of essential metabolic arterial hypertension the paracrin cenosises of nephron and kidneys are secondary involved into realization of pathological compensation and very often are "guilty without guilt" as such another "target organs" as brain, lungs and heart as well.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D062186:Arterial Pressure / Q000502:physiology; D001158:Arteries / Q000503:physiopathology; D012085:Chymosin / Q000378:metabolism; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D010802:Phylogeny; D012084:Renin-Angiotensin System; D014664:Vasodilation / Q000502:physiology
chemical_list: D000804:Angiotensin II; D000450:Aldosterone; D012085:Chymosin