title: Comparison Between IGL-1 and HTK Preservation Solutions in Deceased Donor Liver Transplantation.
abstract: The effectiveness of liver preservation solutions remains in evidence. Cold ischemia time, steatosis, expanded criterion donors, operational cost, and survival represent important roles in its success. In a prospective cohort study between August 2009 and April 2014, 178 patients were allocated into an Institut Georges Lopez - 1 (IGL-1) solution group (63.5%) or histidine-tryptophan-ketoglutarate (HTK) group (36.5%). There were no differences among recipient's characteristics including age, skin color, gender, Model for End-stage Liver Disease score, acute rejection, cholestasis, and reperfusion syndrome incidences. Also, donors, age average, skin color, donor risk index, time in intensive care unit, hemodynamic variables, infections, and steatosis incidences were similar. The average cold ischemia time was 494 minutes in the IGL-1 group and 489 minutes in the HTK group (P = .77). Alanine aminotransferase and aspartate aminotransferase serum levels on the first postoperative day were 707 and 1185 mg/dL, respectively, with IGL-1 and 1298 and 2291 mg/dL, respectively, with HTK (P = .016) and similar at day 15 (P > .88). The incidence of delayed graft function was 4.5% with IGL-1 and 4.6% with HTK (P = .90). The incidence primary nonfunction was 2.7% with IGL-1 and 3.1% with HTK (P = .71). The incidence of perioperative death was 11.5% with IGL-1 and 13.8% with HTK (P = .94). The survival in 30 months was 86% in IGL-1 group and 82% in HTK group (P = .66). Both preservation solutions are efficient to liver transplantations with deceased donors. Major prospective trials are necessary to evaluate each preservation solution's particularities. The preservation solution availability in each transplantation center must guide its use at the present moment.
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil. Electronic address: mario.meine@gmail.com.
authors.forename: M H
authors.initials: MH
authors.lastname: Meine
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Leipnitz
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil; Federal University of Rio Grande do Sul, UFRGS, School of Medicine, Porto Alegre, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Zanotelli
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: E S
authors.initials: ES
authors.lastname: Schlindwein
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Kiss
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Martini
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: de Medeiros Fleck
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Mucenic
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil; Health Sciences Faculty Foundation of Porto Alegre, FFCMPA, Porto Alegre, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: de Mello Brandão
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil; Health Sciences Faculty Foundation of Porto Alegre, FFCMPA, Porto Alegre, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Marroni
authors.affiliation: Hepatic Transplant Group, Dom Vicente Scherer Hospital, HDVS, Irmandade Santa Casa de Misericórdia Hospital Complex of Porto Alegre, ISCMPA, Porto Alegre, Brazil; Federal University of Rio Grande do Sul, UFRGS, School of Medicine, Porto Alegre, Brazil.
authors.forename: G P
authors.initials: GP
authors.lastname: Craco Cantisani
mesh_terms: D000328:Adult; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008875:Middle Aged; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D011184:Postoperative Period; D011189:Potassium Chloride / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011446:Prospective Studies; D012189:Retrospective Studies; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods*
chemical_list: C039984:Bretschneider cardioplegic solution; C504757:IGL-1 solution; D019188:Organ Preservation Solutions; D008353:Mannitol; D011343:Procaine; D011189:Potassium Chloride; D005947:Glucose