title: Cardiorespiratory fitness in survivors of cervical, endometrial, and ovarian cancers: The Cooper Center Longitudinal Study.
abstract: BACKGROUND
  Cardiorespiratory fitness (CRF), a strong predictor of mortality, is impaired among cancer patients. There is limited data, however, regarding CRF levels in women diagnosed with gynecologic cancers.
  
  
  METHODS
  We compared CRF among ovarian, endometrial, and cervical cancer cases (n=89) to age-matched controls (n=89) in the Cooper Center Longitudinal Study (CCLS). CRF was evaluated by a maximal treadmill exercise tolerance test using a modified-Balke protocol. Conditional logistic regression was used to test for case-control differences in cardiorespiratory fitness, after controlling for age and body mass index, and adhering to the matched pairs design.
  
  
  RESULTS
  The mean ages of cancer cases and controls were 50.9 years and 51.1 years, respectively (p=0.81). Peak METs (1 MET=3.5 mL kg(-1)min(-1)) were 9.2 ± 2.0 in cancer cases compared to 10.0 ± 2.2 in controls (p=0.03). When stratifying by type of cancer, peak METs were 8.9 ± 2.2, 8.4 ± 1.9, 9.5 ± 2.0 for patients with ovarian, endometrial, and cervical cancer, respectively. A gynecological cancer diagnosis was associated with greater odds of having 1-MET lower CRF compared to controls (OR 1.31, 95% CI: 1.05-1.64, p=0.018), after controlling for age and BMI.
  
  
  CONCLUSIONS
  Gynecologic cancer survivors were more likely to have a 1-MET lower CRF than controls. Given a 1-MET change in CRF is associated with a significant, we advocate for more robust research regarding CRF in gynecologic cancer patients.
authors.affiliation: University of Vermont College of Medicine, Burlington, VT, USA.
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Peel
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Barlow
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: David
authors.initials: D
authors.lastname: Leonard
authors.affiliation: The Cooper Institute, Dallas, TX, USA.
authors.forename: Laura F
authors.initials: LF
authors.lastname: DeFina
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, NY, USA.
authors.forename: Lee W
authors.initials: LW
authors.lastname: Jones
authors.affiliation: University of Vermont College of Medicine, Burlington, VT, USA; Department of Internal Medicine, Vermont Center on Behavior and Health, Vermont Cancer Center, University of Vermont, Burlington, VT, USA. Electronic address: susan.lakoski@uvm.edu.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Lakoski
mesh_terms: D002318:Cardiovascular Diseases / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000503:physiopathology / Q000628:therapy; D005080:Exercise Test; D005260:Female; D005833:Genital Neoplasms, Female / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000503:physiopathology / Q000628:therapy; D011446:Prospective Studies; D017741:Survivors; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000628:therapy
keywords: Cardiorespiratory fitness; Cervical cancer; Endometrial cancer; Gynecologic cancer; Ovarian cancer