title: Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines.
abstract: A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Jinkun
authors.initials: J
authors.lastname: Huang
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Tsang-Lin
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Maosheng J
authors.initials: MJ
authors.lastname: Chen
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Tedrow
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Farrell
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Bio
authors.affiliation: Drug Substance Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States.
authors.forename: Sheng
authors.initials: S
authors.lastname: Cui
mesh_terms: D054879:Halogenation; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006846:Hydrocarbons, Halogenated; D011725:Pyridines; C013229:pyridine N-oxide