title: Simulation of Chemoperfusion Treatment for Abdominal Carcinomatosis.
abstract: Experimental perfusion system and technology for normothermic and hyperthermic intraperitoneal chemoperfusion are developed for the treatment of abdominal carcinomatosis in rats with transplanted ovarian cancer. MTD of cisplatin in normothermic intraperitoneal chemoperfusion and hyperthermic perfusion are 40 and 20 mg/kg, i.e. by 10- and 5-fold higher than the dose of this cytostatic for routine intraperitoneal injection. Normothermic intraperitoneal chemoperfusion with cisplatin increases median survival time by 200% (p=0.039) in comparison with intraperitoneal injection.
authors.affiliation: Laboratory of Cancer Chemotherapeutic Prevention and Oncopharmacology, N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia, bespalov_niio@mail.ru.
authors.forename: V G
authors.initials: VG
authors.lastname: Bespalov
authors.forename: O A
authors.initials: OA
authors.lastname: Belyaeva
authors.forename: G S
authors.initials: GS
authors.lastname: Kireeva
authors.forename: K Yu
authors.initials: KY
authors.lastname: Senchik
authors.forename: A N
authors.initials: AN
authors.lastname: Stukov
authors.forename: A M
authors.initials: AM
authors.lastname: Belyaev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral / Q000379:methods*; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010534:Peritoneal Neoplasms / Q000188:drug therapy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin