title: Population genetic analysis of insertion-deletion polymorphisms in a Brazilian population using the Investigator DIPplex kit.
abstract: The aim of this study was to estimate the diversity of 30 insertion/deletion (INDEL) markers (Investigator(®) DIPplex kit) in a sample of 519 individuals from six Brazilian states and to evaluate their applicability in forensic genetics. All INDEL markers were found to be highly polymorphic in the Brazilian population and were in Hardy-Weinberg equilibrium. To determine their forensic suitability in the Brazilian population, the markers were evaluated for discrimination power, match probability and exclusion power. The combined discrimination power (CDP), combined match power (CMP) and combined power of exclusion (CPE) were higher than 0.999999, 3.4 × 10(-13) and 0.9973, respectively. Further comparison of 29 worldwide populations revealed significant genetic differences between continental populations and a closer relationship between the Brazilian and European populations.
authors.affiliation: Laboratório de Genética Humana e Médica - Universidade Federal do Pará - UFPA, PA, Brazil; Centro de Pericias Científicas Renato Chaves, PA, Brazil.
authors.forename: Teresinha de Jesus Brabo
authors.initials: TJB
authors.lastname: Ferreira Palha
authors.affiliation: Laboratório de Genética Humana e Médica - Universidade Federal do Pará - UFPA, PA, Brazil; Centro de Pericias Científicas Renato Chaves, PA, Brazil.
authors.forename: Elzemar Martins
authors.initials: EM
authors.lastname: Ribeiro Rodrigues
authors.affiliation: Laboratório de Genética Humana e Médica - Universidade Federal do Pará - UFPA, PA, Brazil.
authors.forename: Giovanna Chaves
authors.initials: GC
authors.lastname: Cavalcante
authors.affiliation: Laboratório de Polimorfismos Genéticos, Universidade Federal de Santa Catarina, SC, Brazil.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marrero
authors.affiliation: Laboratório de Polimorfismos Genéticos, Universidade Federal de Santa Catarina, SC, Brazil.
authors.forename: Ilíada Rainha
authors.initials: IR
authors.lastname: de Souza
authors.affiliation: Instituto Geral de Perícias de Santa Catarina, SC, Brazil.
authors.forename: Clineu Julien
authors.initials: CJ
authors.lastname: Seki Uehara
authors.affiliation: Setor de Genética Molecular - Instituto de Medicina Social e de Criminologia de São Paulo, SP, Brazil.
authors.forename: Carlos Henrique Ares
authors.initials: CHA
authors.lastname: Silveira da Motta
authors.affiliation: Laboratório de Genética Forense - Polícia Civil do Amazonas, AM, Brazil.
authors.forename: Daniela
authors.initials: D
authors.lastname: Koshikene
authors.affiliation: Laboratório de Diagnósticos por DNA - Universidade do Estado do Rio de Janeiro, RJ, Brazil.
authors.forename: Dayse Aparecida
authors.initials: DA
authors.lastname: da Silva
authors.affiliation: Laboratório de Diagnósticos por DNA - Universidade do Estado do Rio de Janeiro, RJ, Brazil.
authors.forename: Elizeu Fagundes
authors.initials: EF
authors.lastname: de Carvalho
authors.affiliation: Laboratório de Genética Forense - Instituto Nacional de Criminalística - Diretoria Técnico-Científica - Polícia Federal - Ministério da Justiça - Brasília, DF, Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Chemale
authors.affiliation: Laboratório de Genética Forense - Instituto Nacional de Criminalística - Diretoria Técnico-Científica - Polícia Federal - Ministério da Justiça - Brasília, DF, Brazil.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Freitas
authors.affiliation: Laboratório de Genética Forense - Instituto Nacional de Criminalística - Diretoria Técnico-Científica - Polícia Federal - Ministério da Justiça - Brasília, DF, Brazil.
authors.forename: Lídia
authors.initials: L
authors.lastname: Alexandre
authors.affiliation: Laboratório de Genética Forense - Instituto Nacional de Criminalística - Diretoria Técnico-Científica - Polícia Federal - Ministério da Justiça - Brasília, DF, Brazil.
authors.forename: Renato T F
authors.initials: RTF
authors.lastname: Paranaiba
authors.affiliation: QIAGEN Biotecnologia, SP, Brazil.
authors.forename: Mirella Perruccio
authors.initials: MP
authors.lastname: Soler
authors.affiliation: Laboratório de Genética Humana e Médica - Universidade Federal do Pará - UFPA, PA, Brazil. Electronic address: sidneysantos@ufpa.br.
authors.forename: Sidney
authors.initials: S
authors.lastname: Santos
mesh_terms: D001938:Brazil; D053803:Forensic Genetics; D005828:Genetics, Population; D006801:Humans; D054643:INDEL Mutation; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide
keywords: Biallelic; Brazilian population; INDEL; Insertion–deletion polymorphisms; Investigator DIPplex(®) kit