title: Association of Toll-like receptor 4 polymorphism with age-dependent systolic blood pressure increase in patients with coronary artery disease.
abstract: BACKGROUND
  Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence that Toll-like receptor 4 (TLR4) modulate inflammation and contribute to age-dependent SBP increase. However, there are no data about TLR4 and age-dependent blood pressure increase in human.
  
  
  RESULTS
  We therefor investigate a human cohort of 2679 patients with CAD aged between 50-80 years. Genotypes were determined for the TLR4 single nucleotide polymorphism rs4986790 (TLR4 896A/G). Patients were stratified according to tertiles of age and the upper tertile was compared to lower tertiles. In this cohort we show that older patients with the TLR4 896 G allele had significantly lower SBP (TLR4 G allele carriers: 148.2 ± 30.4 mmHg versus A/A allele carrier: 154.9 ± 27.2 mmHg; P < 0.05) and lower pulse pressure (TLR4 G allele carriers: 69.1 ± 29.7 mmHg versus A/A allele carrier: 75.5 ± 26.4 mmHg; P < 0.05) as compared to TLR4 896A/A allele carrier.
  
  
  CONCLUSIONS
  We demonstrate an association between the TLR4 SNP rs4986790 genotype and age-dependant blood pressure increase in patients with coronary artery disease.
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Schneider
authors.affiliation: Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636 Munich, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Koch
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Hoppmann
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Romy
authors.initials: R
authors.lastname: Ubrich
authors.affiliation: Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kemmner
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Steinlechner
authors.affiliation: Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Heemann
authors.affiliation: Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.|German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Oudenarder Straße 16, 13347 Munich, Germany.
authors.forename: Karl-Ludwig
authors.initials: KL
authors.lastname: Laugwitz
authors.affiliation: Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636 Munich, Germany.|German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Oudenarder Straße 16, 13347 Munich, Germany.
authors.forename: Adnan
authors.initials: A
authors.lastname: Kastrati
authors.affiliation: Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str.22, 81675 Munich, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Baumann
keywords: Ageing; Hypertension; TLR4; Toll-like receptor 4