title: Calcium affinity of human α-actinin 1.
abstract: Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and the EF-hand motifs. Therefore, any functional or structural distinction should involve this part of the protein. To investigate this further, the calcium affinities of these three isoforms of α-actinin 1 have been determined by isothermal calorimetry.
authors.affiliation: Department of Chemistry, Umeå University , Umeå , Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Backman
keywords: EF-hand; calcium binding; α-actinin