title: Development of biodegradable Zn-1X binary alloys with nutrient alloying elements Mg, Ca and Sr.
abstract: Biodegradable metals have attracted considerable attentions in recent years. Besides the early launched biodegradable Mg and Fe metals, Zn, an essential element with osteogenic potential of human body, is regarded and studied as a new kind of potential biodegradable metal quite recently. Unfortunately, pure Zn is soft, brittle and has low mechanical strength in the practice, which needs further improvement in order to meet the clinical requirements. On the other hand, the widely used industrial Zn-based alloys usually contain biotoxic elements (for instance, ZA series contain toxic Al elements up to 40 wt.%), which subsequently bring up biosafety concerns. In the present work, novel Zn-1X binary alloys, with the addition of nutrition elements Mg, Ca and Sr were designed (cast, rolled and extruded Zn-1Mg, Zn-1Ca and Zn-1Sr). Their microstructure and mechanical property, degradation and in vitro and in vivo biocompatibility were studied systematically. The results demonstrated that the Zn-1X (Mg, Ca and Sr) alloys have profoundly modified the mechanical properties and biocompatibility of pure Zn. Zn-1X (Mg, Ca and Sr) alloys showed great potential for use in a new generation of biodegradable implants, opening up a new avenue in the area of biodegradable metals.
authors.affiliation: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Li
authors.affiliation: 1] Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China [2] The Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China [3] The Department of Orthopedics, Zhongda Hospital, the Southeast University, Nanjing, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Xie
authors.affiliation: State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Zheng
authors.affiliation: College of Physics, Peking University, Beijing 100871, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cong
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University,Harbin, China.
authors.forename: F Y
authors.initials: FY
authors.lastname: Zhou
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University,Harbin, China.
authors.forename: K J
authors.initials: KJ
authors.lastname: Qiu
authors.affiliation: Center for Biomedical Materials and Engineering, Harbin Engineering University,Harbin, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: L
authors.initials: L
authors.lastname: Tian
authors.affiliation: Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: L
authors.initials: L
authors.lastname: Qin
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002118:Calcium / Q000737:chemistry*; D003343:Corrosion; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D008274:Magnesium; D015032:Zinc; D002118:Calcium