title: TPC: the NAADP discovery channel?
abstract: The Ca2+-mobilizing second messenger, NAADP (nicotinic acid adenine dinucleotide phosphate), has been with us for nearly 20 years and yet we still cannot fully agree on the identity of its target Ca2+-release channel. In spite of some recent robust challenges to the idea that two-pore channels (TPCs) represent the elusive "NAADP receptor", evidence continues to accumulate that TPCs are important for NAADP-mediated responses. This article will briefly outline the background and review more recent work pertaining to the TPC story.
authors.affiliation: *Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, U.K.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Morgan
authors.affiliation: *Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, U.K.
authors.forename: Lianne C
authors.initials: LC
authors.lastname: Davis
authors.affiliation: *Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, U.K.
authors.forename: Margarida
authors.initials: M
authors.lastname: Ruas
authors.affiliation: *Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, U.K.
authors.forename: Antony
authors.initials: A
authors.lastname: Galione
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020013:Calcium Signaling / Q000235:genetics*; D011992:Endosomes / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics; D008247:Lysosomes / Q000378:metabolism; D008564:Membrane Potentials / Q000235:genetics; D009249:NADP / Q000031:analogs & derivatives* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D009249:NADP; C024376:NAADP; D002118:Calcium