title: Development of the fentanyl iontophoretic transdermal system (ITS) for patient-controlled analgesia of postoperative pain management.
abstract: The fentanyl iontophoretic transdermal system (ITS) is a needle-free, patient-activated drug delivery system used for patient-controlled analgesia in adult hospitalized patients with postoperative pain. The system design has been updated to a separated system consisting of a Controller and a Drug Unit, and has had regulatory submissions in USA and Europe in 2014. Fentanyl ITS has been shown to be therapeutically equivalent to morphine intravenous (iv.) patient-controlled analgesia. One of the advantages of fentanyl ITS is that patients have better mobility as there is no need for an iv. pump, iv. lines and pole. The introduction of the updated fentanyl ITS will add a versatile tool to the postoperative pain management armamentarium.
authors.affiliation: Department of Anesthesiology, Memorial Hermann Memorial City Medical Center, Houston, TX 77024, USA.
authors.forename: Harold S
authors.initials: HS
authors.lastname: Minkowitz
authors.affiliation: The Medicines Company, Parsippany, NJ 07054, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Danesi
authors.affiliation: The Medicines Company, Parsippany, NJ 07054, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.affiliation: The Medicines Company, Parsippany, NJ 07054, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Jones
mesh_terms: D000279:Administration, Cutaneous; D016058:Analgesia, Patient-Controlled / Q000295:instrumentation / Q000379:methods*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007478:Iontophoresis / Q000379:methods; D059408:Pain Management; D010149:Postoperative Pain / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl
keywords: fentanyl; iontophoretic transdermal system; morphine; patient-controlled analgesia; postoperative pain