title: Simple amides of oleanolic acid as effective penetration enhancers.
abstract: Transdermal transport is now becoming one of the most convenient and safe pathways for drug delivery. In some cases it is necessary to use skin penetration enhancers in order to allow for the transdermal transport of drugs that are otherwise insufficiently skin-permeable. A series of oleanolic acid amides as potential transdermal penetration enhancers was formed by multistep synthesis and the synthesis of all newly prepared compounds is presented. The synthetized amides of oleanolic acid were tested for their in vitro penetration promoter activity. The above activity was evaluated by means of using the Fürst method. The relationships between the chemical structure of the studied compounds and penetration activity are presented.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka Str. 6, 60-780 Poznan, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bednarczyk-Cwynar
authors.affiliation: Department of Technology of Drug Forms, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka Str. 6, 60-780 Poznan, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Partyka
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka Str. 6, 60-780 Poznan, Poland.
authors.forename: Lucjusz
authors.initials: L
authors.lastname: Zaprutko
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008567:Membranes, Artificial; D009824:Ointments / Q000494:pharmacology; D009828:Oleanolic Acid / Q000737:chemistry / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D011374:Progesterone / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000577:Amides; D008567:Membranes, Artificial; D009824:Ointments; D011374:Progesterone; D009828:Oleanolic Acid