title: Relationship between serum DHEAS and oxidative stress levels of body mass index in healthy postmenopausal women.
abstract: OBJECTIVE
  Menopause is a natural step in the process of aging. Postmenopausal women have decreased levels of antioxidants and increased oxidative stress, the latter of which plays an important role in atherogenesis. The aim of the present study was to evaluate the relationship of the body mass index (BMI) with serum catalase activity, malondialdehyde (MDA), and dehydroepiandrosterone sulfate (DHEAS) levels in healthy postmenopausal women and estimate whether the MDA/DHEAS ratio is a possible marker of oxidative stress for determining cardiovascular risk in these women.
  
  
  METHODS
  We investigated serum catalase activity, MDA, and DHEAS levels, parity history, age, and BMI in 96 healthy postmenopausal women aged 50-82 years. The serum MDA levels and catalase activity were measured spectrophotometrically. The serum DHEAS levels were measured using an enzyme-linked immunosorbent assay. The ratio percentage of the serum DHEAS levels to serum MDA levels was designated as a biomarker for oxidative stress.
  
  
  RESULTS
  The mean BMI of the patients was 31.72 ± 6.16 kg/m(2) (range = 20.5-47.94). The MDA/DHEAS ratio was significantly decreased in patients with a BMI over 30 compared to that of patients with a BMI between 25 and 30 (P = 0.025). Moreover, BMI was positively correlated with serum DHEAS levels (r = 0.285, P < 0.01) and negatively correlated with the MDA/DHEAS ratio (r = -0.241, P < 0.05) in postmenopausal women. Furthermore, BMI was observed to be a potential predictor of the MDA/DHEAS ratio based on covariance analysis (P = 0.039).
  
  
  CONCLUSIONS
  Our results indicate that healthy, obese, postmenopausal women have a decreased MDA/DHEAS ratio. Additionally, BMI was observed to be a potential predictor of the MDA/DHEAS ratio.
authors.affiliation: a Department of Internal Medicine, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Goy
authors.affiliation: b Department of Endocrinology and Metabolism, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Atmaca
authors.affiliation: a Department of Internal Medicine, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.affiliation: b Department of Endocrinology and Metabolism, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Rıfkı
authors.initials: R
authors.lastname: Ucler
authors.affiliation: b Department of Endocrinology and Metabolism, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alay
authors.affiliation: a Department of Internal Medicine, Medical Faculty , Yuzuncu Yil University , Van , Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Seven
authors.affiliation: c Department of Chemistry, Division of Biochemistry, Faculty of Science , Yuzuncu Yil University , Van , Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.affiliation: d Department of Endocrinology and Metabolism, Medical Faculty , Medipol University , Istanbul , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozturk
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010298:Parity; D017698:Postmenopause / Q000097:blood* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D008315:Malondialdehyde; D019314:Dehydroepiandrosterone Sulfate
keywords: Body mass index; Catalase; Dehydroepiandrosterone sulfate; Menopause; Number of pregnancies; Oxidative stress