title: Chrono- and Immunocorrection of Inflammatory Disorders of Internal Reproductive Organs in Women of Reproductive Age.
abstract: We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case.
authors.affiliation: Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia, litv_g_i@mail.ru.
authors.forename: G I
authors.initials: GI
authors.lastname: Litvinenko
authors.forename: A V
authors.initials: AV
authors.lastname: Shurlygina
authors.forename: T I
authors.initials: TI
authors.lastname: Dergacheva
authors.forename: E V
authors.initials: EV
authors.lastname: Mel'nikova
authors.forename: V A
authors.initials: VA
authors.lastname: Trufakin
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003594:Cytoplasmic Granules / Q000201:enzymology; D055870:Drug Chronotherapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D009869:Oophoritis / Q000188:drug therapy* / Q000276:immunology / Q000628:therapy; D026741:Physical Therapy Modalities; D057285:Precision Medicine; D012330:RNA, Double-Stranded / Q000008:administration & dosage* / Q000494:pharmacology; D012331:RNA, Fungal / Q000008:administration & dosage* / Q000494:pharmacology; D012488:Salpingitis / Q000188:drug therapy* / Q000276:immunology / Q000628:therapy; D013385:Succinate Dehydrogenase / Q000097:blood*; D013951:Thymus Hormones / Q000008:administration & dosage* / Q000494:pharmacology; D016896:Treatment Outcome; D014815:Vitamins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D007155:Immunologic Factors; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D013951:Thymus Hormones; D014815:Vitamins; C076741:ridostin; C032805:thymalin; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase