title: New C13 lipids from the marine-derived fungus Trichoderma harzianum.
abstract: Chemical examination of the fermentation broth of a sponge-associated fungus Trichoderma harzinum HMS-15-3 led to the isolation of four pairs of new C13 lipid enantiomers namely harzianumols A-H (1a-4b). Their structures were elucidated on the basis of extensive spectroscopic (IR, MS, 1D, and 2D NMR) data analysis, including the modified Mosher's method for the assignment of their absolute configurations. The new compounds were evaluated for antihyperlipidemic effects in HepG2 cells.
authors.affiliation: a State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191 , China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Qi-Xi
authors.initials: QX
authors.lastname: Huang
authors.forename: Du
authors.initials: D
authors.lastname: Gao
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Ji
authors.forename: Hua-Gang
authors.initials: HG
authors.lastname: Liu
authors.forename: Wen-Han
authors.initials: WH
authors.lastname: Lin
mesh_terms: D000818:Animals; D008055:Lipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D008055:Lipids
keywords: Trichoderma harzinum; harzianumols A–H; structural elucidation