title: Acylated neo-clerodanes and 19-nor-neo-clerodanes from the aerial parts of Scutellaria coleifolia (Lamiaceae).
abstract: Scutefolides A1 and A2, two acylated neo-clerodanes with a 19,18-γ-lactone, scutefolides B1, B2 and C, three 19-nor-neo-clerodanes, together with scutefolides D, E1, E2 and F, four neo-clerodanes, were isolated from the EtOAc-soluble fraction of the aerial parts of Scutellaria coleifolia. Their structures were established on the basis of spectroscopic analysis. The absolute configurations of four of these compounds were elucidated by the CD exciton chirality method. Cytotoxic activities of scutefolides D-F against four cancer cell lines (KB, A549, HeLa, and MCF7) were also evaluated, but they were inactive.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima 7708505, Japan.
authors.forename: Shin-Ichiro
authors.initials: SI
authors.lastname: Kurimoto
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima 7708505, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tokushima University, 1-78 Shomachi, Tokushima 7708505, Japan. Electronic address: kasiwada@tokushima-u.ac.jp.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D031363:Scutellaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal
keywords: Diterpenoid; Lamiaceae; Neo-clerodane; Scutellaria coleifolia