title: Differential genomic damage in different tumor lines induced by prodigiosin.
abstract: Prodigiosin is a secondary metabolite produced by Serratia marcercens. As this pigment is suggested to be a cancer drug, genotoxicity studies are necessary. The aim of the present investigation was to evaluate the genotoxic effects of prodigiosin on tumoral and normal cell lines, NCIH-292, MCF-7 and HL-60. A normal line BGMK was used as control. Genomic damage induced by prodigiosin was observed in all tumor lines as well as the control line. The pigment induced the formation of micronuclei in tumor cells. The present data confirm the antitumor potential of prodigiosin. However, these findings also raise concerns regarding its target-specific action, as genotoxic effects on normal cells also occurred.
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Recife, Brazil jeannecantalice@gmail.com.
authors.forename: Jeanne Cristina Lapenda
authors.initials: JC
authors.lastname: Lins
authors.affiliation: Department of Parasitology, Mutagenesis Laboratory, Aggeu Magalhães Research Center, Recife, Brazil.
authors.forename: Maria Eliane Bezerra
authors.initials: ME
authors.lastname: DE Melo
authors.affiliation: Department of Antibiotics, Federal University of Pernambuco, Recife, Brazil.
authors.forename: Silene Carneiro
authors.initials: SC
authors.lastname: DO Nascimento
authors.affiliation: Department of Biological Sciences, Federal University of Pernambuco with Academic Center of Vitória, Pernambuco, Brazil.
authors.forename: Monica Lucia
authors.initials: ML
authors.lastname: Adam
mesh_terms: D004249:DNA Damage / Q000187:drug effects*; D015894:Genome, Human / Q000187:drug effects*; D006801:Humans; D061986:MCF-7 Cells; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011353:Prodigiosin / Q000008:administration & dosage* / Q000009:adverse effects; D012705:Serratia / Q000737:chemistry / Q000472:pathogenicity; D016868:Serratia Infections / Q000150:complications / Q000188:drug therapy / Q000235:genetics
chemical_list: D011353:Prodigiosin
keywords: genotoxicity; micronucleus; prodigiosin; tumor cells