title: Clarifying the role of condensin in shaping chromosomes.
abstract: A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and disentanglement of sister chromatids and by conferring rigidity to chromosomes.
authors.affiliation: Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Ariake 3-8-31, Koto-ku, Tokyo 135-8550, Japan.
authors.forename: Kota
authors.initials: K
authors.lastname: Nagasaka
authors.affiliation: Division of Experimental Pathology, Cancer Institute of the Japanese Foundation for Cancer Research (JFCR), Ariake 3-8-31, Koto-ku, Tokyo 135-8550, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hirota
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D020090:Chromosome Segregation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D008540:Meiosis / Q000502:physiology*; D046912:Multiprotein Complexes / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics*
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D000251:Adenosine Triphosphatases