title: The SUMO conjugating enzyme UBC9 as a biomarker for cervical HPV infections.
abstract: Human papillomaviruses (HPVs) infect stratified epithelium and are the causative agents of cervical cancer, the second most common cause of cancer-related death in women. A critical aspect that still persists in the HPV field is the selection of very sensitive and specific HPV diagnostic assays. Here, we provide evidence that the crucial small ubiquitin-like modifier (SUMO) E2-conjugating enzyme Ubc9 is strongly upregulated in cervical lesions. Ubc9 detection could thus be used in diagnosing and/or monitoring the progression of an HPV oncogenic infection.
authors.affiliation: European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy ; Equally contributed to this work.
authors.forename: Domenico
authors.initials: D
authors.lastname: Mattoscio
authors.affiliation: European Institute of Oncology, Department of Pathology, 20141 Milan, Italy ; Equally contributed to this work.
authors.forename: Chiara
authors.initials: C
authors.lastname: Casadio
authors.affiliation: TTFactor Srl, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Fumagalli
authors.affiliation: European Institute of Oncology, Division of Gynecology, 20141 Milan, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Sideri
authors.affiliation: European Institute of Oncology, Department of Experimental Oncology, Via Adamello 16, 20139 Milan, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Chiocca
keywords: HPV; HSIL; LSIL; SUMO; Ubc9; biomarker; cervical cancer