title: The contractome--a systems view of actomyosin contractility in non-muscle cells.
abstract: Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell Science at a Glance article and the accompanying poster, we mined the literature and databases to map the contractome of non-muscle cells. Actomyosin contractility is involved in at least 49 distinct cellular functions that range from providing cell architecture to signal transduction and nuclear activity. Containing over 100 scaffolding and regulatory proteins, the contractome forms a highly complex network with more than 230 direct interactions between its components, 86 of them involving phosphorylation. Mapping these interactions, we identify the key regulatory pathways involved in the assembly of actomyosin structures and in activating myosin to produce contractile forces within non-muscle cells at the exact time and place necessary for cellular function.
authors.affiliation: Mechanobiology Institute, National University of Singapore, T-lab building #05-01, 5A Engineering Drive 1, 117411, Singapore biezbr@nus.edu.sg lux@post.tau.ac.il.
authors.forename: Ronen
authors.initials: R
authors.lastname: Zaidel-Bar
authors.affiliation: Mechanobiology Institute, National University of Singapore, T-lab building #05-01, 5A Engineering Drive 1, 117411, Singapore.
authors.forename: Guo
authors.initials: G
authors.lastname: Zhenhuan
authors.affiliation: Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv 69978, Israel biezbr@nus.edu.sg lux@post.tau.ac.il.
authors.forename: Chen
authors.initials: C
authors.lastname: Luxenburg
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology*; D000205:Actomyosin / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D053263:Gene Regulatory Networks; D006801:Humans; D010766:Phosphorylation; D060066:Protein Interaction Maps; D015398:Signal Transduction
chemical_list: D000205:Actomyosin
keywords: Contractility; Myosin II; Non-muscle cells