title: Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review.
abstract: BACKGROUND
  Hepatic resection of liver metastases of non-colorectal, non-neuroendocrine, and non-sarcoma (NCNNNS) primary malignancies seems to improve survival in selected patients. The aims of the current review were to describe long-term results of surgery and to evaluate prognostic factors for survival in patients who underwent resection of NCNNNS liver metastases.
  
  
  METHODS
  We identified 30 full texts (25 single-center and 5 multicenter studies) published after year 1995 and published in English with a total of 3849 patients. For NCNNNS liver metastases, 83.4 % of these subjects were resected.
  
  
  RESULTS
  No prior systematic reviews or meta-analyses on this topic were identified. All studies were case series without matching control groups. The most common primary sites were breast (23.8 %), genito-urinary (21.8 %), and gastrointestinal tract (19.8 %). The median 5- and 10-year overall survival were 32.3 % (range 19-42 %) and 24 % (indicated only in two studies, range 23-25 %), respectively, with 71 % of R0 resections.
  
  
  CONCLUSIONS
  There is evidence suggesting that surgery of NCNNNS metastases is safe, feasible, and effective if treatment is part of a multidisciplinary approach and if indication is based on the prognostic factors underlined in literature analysis.
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. fabio.uggeri@unimib.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Uggeri
authors.affiliation: University of Milano-Bicocca, via Cadore 48, Monza, 20900, Italy. broska87@gmail.com.
authors.forename: Paolo Alessandro
authors.initials: PA
authors.lastname: Ronchi
authors.affiliation: Department of Surgery, Duke University, Durham, USA. goffredo.paolo@gmail.com.
authors.forename: Paolo
authors.initials: P
authors.lastname: Goffredo
authors.affiliation: Department of Surgery, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. mattia_garancini@yahoo.it.
authors.forename: Mattia
authors.initials: M
authors.lastname: Garancini
authors.affiliation: Department of Surgery, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. degluc@inwind.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Degrate
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. luca.nespoli@unimib.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Nespoli
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. luca.gianotti@unimib.it.
authors.forename: Luca
authors.initials: L
authors.lastname: Gianotti
authors.affiliation: Department of Surgery and Translational Medicine, University of Milano-Bicocca, San Gerardo Hospital, via Pergolesi 33, Monza, 20900, Italy. fabrizio.romano@unimib.it.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Romano
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D015996:Survival Rate; D014565:Urogenital Neoplasms / Q000473:pathology*