title: [Pharmacokinetic evaluation of afobazole pharmaceutical composition with modified release].
abstract: The main pharmacokinetic parameters (AUC0-∞, Tmax, Cmax, Cl/F, t1/2 el, MRT, Cmax/AUC0-I, Vd/F) of afobazole base in a new pharmaceutical composition and afobazole dihydrochloride substance after single peroral administration have been determined in rats. The availability of afobazole base pharmaceutical composition relative to that of the substance amounted to 153.2%.
authors.forename: P O
authors.initials: PO
authors.lastname: Bochkov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A O
authors.initials: AO
authors.lastname: Viglinskaya
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: E V
authors.initials: EV
authors.lastname: Blynskaya
authors.forename: K V
authors.initials: KV
authors.lastname: Alekseev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001562:Benzimidazoles / Q000493:pharmacokinetics* / Q000494:pharmacology*; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D009025:Morpholines / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051381:Rats
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D003692:Delayed-Action Preparations; D009025:Morpholines