title: [Screening of the anti-tumor active fraction from Ipomoea batatas Lam. (cv.simon) leaves].
abstract: OBJECTIVE
  Three fractions (SM, SM-A, SM-B) were prepared from different polarity parts of Ipomoea batatas Lam. (cv.simon) leaves and the anti-tumor potency as well as the dose-response relations were evaluated.
  
  
  METHODS
  The anti-tumor activities of fraction SM, SM-A or SM-B were screened by MTS in human hepatic cancer Hep3B cells, lung cancer A549 cells or gastric carcinoma MGC803 cells, respectively.
  
  
  RESULTS
  The three fractions all showed anti-tumor activities in three cancer cells with different sensitivity. Among them, SM-B was the most potent fraction with IC50 values at 15.17 mg/L, 72.64 mg/L or 165.47 mg/L in MGC803 cells, A549 cells or Hep3B cells, respectively (P<0.05).
  
  
  CONCLUSIONS
  Th e extraction of Brazil sweet potato leaves displayed anti-tumor activity and SM-B was the most potent fraction.
authors.affiliation: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008; School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
authors.forename: Shuhe
authors.initials: S
authors.lastname: Lü
authors.forename: Cong
authors.initials: C
authors.lastname: Lin
authors.forename: Pingsheng
authors.initials: P
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D027723:Ipomoea batatas / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts