title: Molecular docking and QSAR analyses for understanding the antimalarial activity of some 7-substituted-4-aminoquinoline derivatives.
abstract: The quinoline moiety is one of the widely studied scaffolds for generating derivatives with various pharmacophoric groups due to its potential antimalarial activities. In the present study, a series of 7-substituted-4-aminoquinoline derivatives were selected to understand their antimalarial properties computationally by molecular modeling techniques including 2D QSAR, comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and molecular docking. The 2D-QSAR model built with four descriptors selected by genetic algorithm technique and CoMFA model showed satisfactory statistical results (Q(2)=0.540, R(2)ncv=0.881, F value=157.09). A reliable CoMSIA model out of the fourteen different combinations has a Q(2) value of 0.638. The molecular docking studies of the compounds for 1CET as the protein target revealed that ten compounds showed maximum interactions with the binding site of the protein. The present study highlights the unique binding signatures of the ligands within the active site groove of the target and it explains the subtle differences in their EC50 values and their mechanism of inhibition.
authors.affiliation: Department of Chemistry, Sree Narayana College, Chempazhanthy, Kerala, India. Electronic address: shibiig@gmail.com.
authors.forename: I G
authors.initials: IG
authors.lastname: Shibi
authors.affiliation: Department of Chemistry, Sree Narayana College, Chempazhanthy, Kerala, India.
authors.forename: L
authors.initials: L
authors.lastname: Aswathy
authors.affiliation: Department of Chemistry, Sree Narayana College, Chempazhanthy, Kerala, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Jisha
authors.affiliation: Department of Chemistry, Vidya Bharati College, Camp, Amravati, Maharashtra, India.
authors.forename: V H
authors.initials: VH
authors.lastname: Masand
authors.affiliation: Department of Chemistry, Sree Narayana College, Chempazhanthy, Kerala, India.
authors.forename: A
authors.initials: A
authors.lastname: Divyachandran
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India.
authors.forename: J M
authors.initials: JM
authors.lastname: Gajbhiye
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D062105:Molecular Docking Simulation; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; C001920:4-aminoquinoline
keywords: (2H-1,3-benzodioxol-4-ylmethyl)(3-{[7-(2-phenylethyl)quinolin-4-yl]amino}propyl)amine (PubChem CID: 56594874); 2-[[3-[[7-(4-chlorophenoxy)-4-quinolyl]amino]propylamino]methyl]-6-methoxy-phenol (PubChem CID: 56593662); 2D-QSAR; CoMFA; CoMSIA; Malaria; Molecular docking; N-(1,3-benzodioxol-4-ylmethyl)-N′-(7-phenethyl-4-quinolyl)propane-1,3-diamine (PubChem CID: 56594623); N-(1,3-benzodioxol-4-ylmethyl)-N′-[7-(4-tert-butylphenoxy)-4-quinolyl]propane-1,3-diamine (PubChem CID: 56593819); N-(2-furylmethyl)-N′-(7-isopentyl-4-quinolyl)propane-1,3-diamine (PubChem CID 56593939); N-(furan-2-ylmethyl)-N′-(7-phenoxyquinolin-4-yl)propane-1,3-diamine (PubChem CID: 56593944); N-[(5-fluoro-2-methoxy-phenyl)methyl]-N′-[7-(3-methoxyphenoxy)-4-quinolyl]propane-1,3-diamine (PubChem CID: 56595146); Plasmodium falciparum