title: Downbeat nystagmus: evidence for enhancement of utriculo-ocular pathways by ocular vestibular evoked myogenic potentials?
abstract: Downbeat nystagmus (DBN) is caused by an impairment of Purkinje cells in the flocculus. The decreased cerebellar inhibitory input affects otolith pathways. Since ocular and cervical vestibular evoked myogenic potentials (o-/cVEMP) test the otoliths, the VEMP were measured in DBN patients and in controls. Sixteen patients with DBN, 14 cerebellar oculomotor disorder patients without DBN (COMD), and 16 healthy controls were examined with o-/cVEMP. Computational modeling was used to predict VEMP differences between groups. DBN patients had significantly higher oVEMP peak-to-peak (PP) amplitudes than COMD patients without DBN and controls. Cervical VEMP did not differ. The computational model of DBN predicted a twofold oVEMP increase for DBN patients. These findings suggest an enhancement of the utriculo-ocular response. The unchanged cVEMP indicate no effect on the otolith-cervical reflex in DBN. Computational modeling suggests that the utriculo-ocular enhancement is caused by an impaired vertical neural integrator resulting in the increased influence of utricular signals. This also explains the gravitational dependence of DBN.
authors.affiliation: German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany. Tatiana.Bremova@med.uni-muenchen.de.|Graduate School of Systemic Neurosciences, LMU Biocenter, Grosshaderner Strasse 2, 82152, Munich, Germany. Tatiana.Bremova@med.uni-muenchen.de.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bremova
authors.affiliation: German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany.|Center for Sensorimotor Research, University Hospital Munich, Feodor-Lynen-Strasse 19, 81377, Munich, Germany.|Department of Neurology, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Glasauer
authors.affiliation: German Center for Vertigo and Balance Disorders, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany.|Department of Neurology, University Hospital Munich, Marchioninistrasse 15, 81377, Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Strupp
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000209:etiology / Q000503:physiopathology*; D015840:Oculomotor Nerve Diseases / Q000503:physiopathology; D010037:Otolithic Membrane / Q000503:physiopathology; D011446:Prospective Studies; D012018:Reflex; D058585:Vestibular Evoked Myogenic Potentials / Q000502:physiology*
keywords: Cerebellar degeneration; Downbeat nystagmus; Otolith; Vestibular function; cVEMP; oVEMP