title: Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population.
abstract: CD157, also referred to as bone marrow stromal cell antigen-1 (BST-1), is a glycosylphosphatidylinositol-anchored molecule that promotes pre-B-cell growth. Previous studies have reported associations between single-nucleotide polymorphisms (SNPs) of the CD157/BST1 gene with Parkinson's disease. In an attempt to determine whether SNPs or haplotypes in the CD157/BST1 are associated with other brain disorders, we performed a case-control study including 147 autism spectrum disorder (ASD) patients at Kanazawa University Hospital in Japan and 150 unselected Japanese volunteers by the sequence-specific primer-polymerase chain reaction method combined with fluorescence correlation spectroscopy. Of 93 SNPs examined, two SNPs showed significantly higher allele frequencies in cases with ASDs than in unaffected controls (rs4301112, OR = 6.4, 95% CI = 1.9 to 22, p = 0.0007; and rs28532698, OR = 6.2, 95% CI = 1.8 to 21, p = 0.0012; Fisher's exact test; p < 0.002 was considered significant after multiple testing correction). In addition, CT genotype in rs10001565 was more frequently observed in the ASD group than in the control group (OR = 15, 95% CI = 2.0 to 117, p = 0.0007; Fisher's exact test). The present data indicate that genetic variation of the CD157/BST1 gene might confer susceptibility to ASDs.
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. shigeruy@med.kanazawa-u.ac.jp.|MEXT Strategic Research Program for Brain Sciences (SRPBS), Okazaki 444-0840, Japan. shigeruy@med.kanazawa-u.ac.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yokoyama
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. naila@med.kanazawa-u.ac.jp.
authors.forename: Naila
authors.initials: N
authors.lastname: Al Mahmuda
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. munesue@med.kanazawa-u.ac.jp.|MEXT Strategic Research Program for Brain Sciences (SRPBS), Okazaki 444-0840, Japan. munesue@med.kanazawa-u.ac.jp.
authors.forename: Toshio
authors.initials: T
authors.lastname: Munesue
authors.affiliation: Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan. kenshi@med.kanazawa-u.ac.jp.
authors.forename: Kenshi
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Medical Education Research Center, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan. diabe@med.kanazawa-u.ac.jp.
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Yagi
authors.affiliation: Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan. myamagi@med.kanazawa-u.ac.jp.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
authors.affiliation: Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan. haruhiro@med.kanazawa-u.ac.jp.|MEXT Strategic Research Program for Brain Sciences (SRPBS), Okazaki 444-0840, Japan. haruhiro@med.kanazawa-u.ac.jp.
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Higashida
keywords: BST-1; CD157; autism spectrum disorder; single-nucleotide polymorphism