title: CGRP as a neuropeptide in migraine: lessons from mice.
abstract: Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of migraine is altered sensory perception. A likely contributor to this altered perception is the neuropeptide calcitonin gene-related peptide (CGRP). Over the past decade, CGRP has become firmly established as a key player in migraine. Although the mechanisms and sites of action by which CGRP might trigger migraine remain speculative, recent advances with mouse models provide some hints. This brief review focuses on how CGRP might act as both a central and peripheral neuromodulator to contribute to the migraine-like symptom of light aversive behaviour in mice.
authors.affiliation: Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, 52242, USA.|Department of Neurology, University of Iowa, Iowa City, IA, 52242, USA.|Veterans Affairs Medical Center, Iowa City, IA, 52246, USA.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Russo
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008881:Migraine Disorders / Q000378:metabolism*; D058262:Receptor Activity-Modifying Protein 1 / Q000235:genetics / Q000378:metabolism
chemical_list: D000700:Analgesics; D000911:Antibodies, Monoclonal; C545505:Ramp1 protein, mouse; D058262:Receptor Activity-Modifying Protein 1; D015740:Calcitonin Gene-Related Peptide
keywords: CGRP; calcitonin gene-related peptide; migraine; mouse model; neuropeptide; photophobia