title: [The characteristics of anemic syndrome in patients with prevalent phases of Hodgkin lymphoma before treatment].
abstract: The study was carried out to analyze peripheral blood covering 23 patients with prevalent phases of Hodgkin lymphoma received no treatment previously. The clinical analysis of blood was implemented using hematologic analyzer Sysmex XE-2100. The content of ferritin, soluble receptors of transferrin and erythropoietin was estimated using enzyme-linked immunosorbent assay. The free hemoglobin was estimated using hemoglobin cyanide method. The direct Coombs test, counting of leukogram and analysis of morphology of erythrocytes were applied to all patients. The anemia is diagnosed in 19 patients (83%). In 18 out of them the anemic syndrome corresponded to anemia of chronic disease and in one patient asiderotic anemia was established. The rest of patients had no anemia. The anemia of chronic diseases characterized by microcytosis and hypochromia of erythrocytes, inadequate degree of anemia by production of erythropoietin and functional deficiency of iron in most of the patients. It should be emphasized that anemia of chronic diseases commonly is normocyte normochrome anemia whereas in patients with prevalent phases of Hodgkin Iymphoma the microcyte hypochrome anemia was detected before the treatment and it was followed by functional deficiency of iron. In patients without anemic syndrome microcytosis and hypochromia of erythrocytes were marked too. The techniques of laboratory diagnostic objectively reflecting iron metabolism (evaluation of level of soluble receptors of transferrin andferritin) and appropriate hormonal response to degree of anemia (production of erythropoietin) are to be included into algorithm of treatment of patients. The purpose is to timely detect type of anemia with the purpose of its appropriate correction prior to treatment onset.
authors.forename: G N
authors.initials: GN
authors.lastname: Zubrikhina
authors.forename: V N
authors.initials: VN
authors.lastname: Blindar
authors.forename: I I
authors.initials: II
authors.lastname: Matveeva
authors.forename: E A
authors.initials: EA
authors.lastname: Demina
mesh_terms: D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood* / Q000150:complications / Q000473:pathology; D004912:Erythrocytes / Q000473:pathology; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D006689:Hodgkin Disease / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D008297:Male; D008875:Middle Aged; D014168:Transferrin / Q000032:analysis
chemical_list: D014168:Transferrin; D004921:Erythropoietin; D005293:Ferritins; D007501:Iron