title: Distribution of citrate and citrate infusion rate during donor plasmaphereses.
abstract: BACKGROUND
  The purpose of this study was to describe the distribution of trisodium-citrate 4% (TSC) anticoagulant (AC) between the product and the donors undergoing plasma donation.
  
  
  METHODS
  Data of 32 regular donors of plasma initially collected for a study published in 2010 were re-analyzed to determine the amount of citrate received by the donor and the citrate infusion rate (CIR) in mg/kg/min to the donor. Donor plasmaphereses (DP) were performed with the automated Haemonetics plasma collecting system 2 (PCS2). Plasma volume was programmed at 760 ml including AC. CIR was calculated from citrate received by the donors divided by the body weight over time.
  
  
  RESULTS
  130 ± 12 ml TSC was used for 760 ml plasma. An average of 110 ml TSC or 84.6% of citrate load was in collected plasma and not given to the donor. From the difference of 20 ml or 514 mg citrate an average CIR of 0.16 mg/kg/min was calculated.
  
  
  CONCLUSIONS
  The total amount of citrate received by the donor is minimal and the average CIR is below the critical level of 1 mg/kg/min.
authors.affiliation: Octapharma Plasma, Plasmazentrum Aachen, Aachen, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Evers
authors.affiliation: Octapharma Plasma, Plasmazentrum Aachen, Aachen, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Taborski
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood*; D001782:Blood Donors; D002951:Citrates / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D002951:Citrates; D007074:Immunoglobulin G; C514290:trisodium citrate
keywords: apheresis; citrate; citrate infusion rate; citrate toxicity; plasmapheresis