title: Taiwanin A incorporated polyurethane fiber sheets for prevention of postoperative cancer recurrence.
abstract: In this study, we propose a single solution for prevention of postoperative complications and recurrence of highly metastatic gastrointestinal tract cancers. Here, we demonstrate preparation and characterization of Taiwanin A incorporated polyurethane fiber sheets with excellent mechanical properties and sustained drug release. Sheets with elastic modulus of 8 MPa and ultimate tensile strength of 30 MPa will provide support on surgical staple line preventing leakage at anastomosis. Slight burst release of the drug within 7 days (15%) and further sustained release will inhibit proliferation and migration of remaining cancer cells and maintain locoregional high drug concentration to prevent recurrence of the disease. High elasticity of the material will promote healing process without impeding natural peristalsis movement of gastrointestinal organs.
authors.affiliation: a Department of Frontier Fiber Technology and Science , Graduate School of Engineering, University of Fukui , Fukui 910-8507 , Japan.
authors.forename: Onon
authors.initials: O
authors.lastname: Batnyam
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Uematsu
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Chou
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Suye
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
mesh_terms: D016475:3T3 Cells; D057868:Anastomotic Leak / Q000517:prevention & control; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000009:adverse effects; D065546:Drug Liberation; D055119:Elastic Modulus; D005663:Furans / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control / Q000601:surgery; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D008567:Membranes, Artificial; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011140:Polyurethanes / Q000009:adverse effects / Q000737:chemistry*; D011183:Postoperative Complications / Q000517:prevention & control*; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005663:Furans; D017705:Lignans; D008567:Membranes, Artificial; D011140:Polyurethanes; C419332:taiwanin A
keywords: Taiwanin A; cancer recurrence; controlled drug release; nanofiber; polyurethane