title: Impact of body mass on recurrence and progression in Chinese patients with Ta, T1 urothelial bladder cancer.
abstract: OBJECTIVE
  To evaluate the impact of body mass on recurrence and progression in patients with Ta, T1 urothelial bladder cancer.
  
  
  METHODS
  Data from 469 patients with Ta, T1 bladder cancer who were treated with transurethral resection of bladder tumor at our center during 2006-2014 were retrospectively studied. According to body mass index (BMI), patients were divided into three groups: normal weight (BMI < 24 kg/m(2)), overweight (24 kg/m(2) ≤ BMI < 28 kg/m(2)) and obesity (BMI ≥ 28 kg/m(2)). Clinicopathologic features were compared across groups. Kaplan-Meier curves and Cox proportional hazards regression analyses were employed to assess the association between body mass and oncologic outcomes.
  
  
  RESULTS
  Compared with patients with normal weight, overweight and obese counterparts showed significantly shorter recurrence-free or progression-free survival. In multivariate analyses, being overweight was an independent factor for recurrence and obesity was for both recurrence and progression. The presence of diabetes mellitus (DM) was not a strong risk factor for the entire cohort, while it became a significant predictor for both recurrence and progression in the subgroup of overweight and obese patients.
  
  
  CONCLUSIONS
  Excessive body mass seems to act as independent risk factors for worse oncologic outcomes of Ta, T1 bladder cancer. Further studies should be carried out to elucidate the exact impact of obesity, DM or even other metabolic disorders.
authors.affiliation: Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, No. 197, 2nd Ruijin Road, Shanghai, 200025, China.
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Xu
authors.forename: Zhaowei
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xianjin
authors.initials: X
authors.lastname: Wang
authors.forename: Leilei
authors.initials: L
authors.lastname: Xia
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhang
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.forename: Fukang
authors.initials: F
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Zhoujun
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000368:Aged; D044466:Asian People; D015992:Body Mass Index; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D002681:China / Q000453:epidemiology; D015653:Cystectomy / Q000379:methods / Q000706:statistics & numerical data; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery