title: Functional imaging of radiation liver injury in a liver metastasis patient: imaging and pathologic correlation.
abstract: BACKGROUND
  Radiation therapy (RT) is increasingly being utilized as a treatment modality for the treatment of primary and metastatic liver malignancies. Accurate assessment of liver function and prediction of radiation induced liver disease (RILD) remains a challenge with conventional laboratory tests and imaging. Imaging-pathology correlation of hepatic injury after RT has been described with computer tomography (CT) imaging that depicts perfusion changes. However, these imaging changes may not directly characterize the functional capacity of the liver.
  
  
  METHODS
  This case report describes a patient that received preoperative chemoradiation and surgical resection for a liver metastasis from endometrial cancer. Sulfur colloid (SC) single photon emission computed tomography (SPECT/CT) was obtained post-chemoradiation and prior to surgery. Imaging-pathology correlation between radiation changes depicted on functional imaging using SC SPECT/CT and corresponding histopathology is described.
  
  
  CONCLUSIONS
  Quantitative SC SPECT/CT may allow non-invasive assessment of global and spatial liver function before treatment and enable personalized treatment approaches for liver-directed therapies.
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Tobias R
authors.initials: TR
authors.lastname: Chapman
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Asangi R
authors.initials: AR
authors.lastname: Kumarapeli
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Nyflot
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bowen
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Raymond S
authors.initials: RS
authors.lastname: Yeung
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Hubert J
authors.initials: HJ
authors.lastname: Vesselle
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Yeh
authors.affiliation: 1 Department of Radiation Oncology, 2 Department of Pathology, 3 Department of Surgery, 4 Division of Nuclear Medicine and Department of Radiology, University of Washington, Seattle, WA 98195, USA.
authors.forename: Smith
authors.initials: S
authors.lastname: Apisarnthanarax
keywords: Liver metastasis; functional imaging; radiation induced liver disease (RILD); radiation therapy (RT)