title: Molecular architecture and biomedical leads of terpenes from red sea marine invertebrates.
abstract: Marine invertebrates including sponges, soft coral, tunicates, mollusks and bryozoan have proved to be a prolific source of bioactive natural products. Among marine-derived metabolites, terpenoids have provided a vast array of molecular architectures. These isoprenoid-derived metabolites also exhibit highly specialized biological activities ranging from nerve regeneration to blood-sugar regulation. As a result, intense research activity has been devoted to characterizing invertebrate terpenes from both a chemical and biological standpoint. This review focuses on the chemistry and biology of terpene metabolites isolated from the Red Sea ecosystem, a unique marine biome with one of the highest levels of biodiversity and specifically rich in invertebrate species.
authors.affiliation: Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt. elamir77@live.com.
authors.forename: Mohamed Elamir F
authors.initials: ME
authors.lastname: Hegazy
authors.affiliation: Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt. tarik.nrc83@yahoo.com.
authors.forename: Tarik A
authors.initials: TA
authors.lastname: Mohamed
authors.affiliation: National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt. coralreef_niof1@yahoo.com.
authors.forename: Montaser A
authors.initials: MA
authors.lastname: Alhammady
authors.affiliation: Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt. alaasaidalah_shaheen@yahoo.com.
authors.forename: Alaa M
authors.initials: AM
authors.lastname: Shaheen
authors.affiliation: Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, Egypt. dremanhusseinreda@gmail.com.
authors.forename: Eman H
authors.initials: EH
authors.lastname: Reda
authors.affiliation: Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st. (former El Tahrir st.) Dokki, Giza, P.O. Box 12622, Egypt. elshamynrc@yahoo.com.
authors.forename: Abdelsamed I
authors.initials: AI
authors.lastname: Elshamy
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. drmina_aziz06@yahoo.com.
authors.forename: Mina
authors.initials: M
authors.lastname: Aziz
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. Paul.Pare@ttu.edu.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000818:Animals; D044822:Biodiversity; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D017753:Ecosystem; D006801:Humans; D019156:Indian Ocean; D007448:Invertebrates / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D013729:Terpenes
keywords: Red Sea; biomedical leads; marine ecosystem; marine invertebrates; terpenes