title: Pharmacological investigations of new galantamine peptide esters.
abstract: Galantamine hydrobromide (GAL) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. The aim of this study is to determine the effect of new galantamine peptide esters: 3,4-dichlorophenyl-alanil-leucil-glycine-galantamine (GAL-LEU) and 3,4-dichlorophenyl-alanil-valil-glycine-galantamine (GAL-VAL), on locomotor activity in mice and cognitive processes in experimental model of learning and memory in rats. The results showed that per oral administration of GAL-LEU in a dose of 3 mg per kg improved the cognitive processes by increasing the conditional avoidances and learning ability after the 5th day of application and preserved the memory at the 12th day of the study.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Dobrina
authors.initials: D
authors.lastname: Tsvetkova
authors.affiliation: Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Danchev
authors.affiliation: Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Irina
authors.initials: I
authors.lastname: Nikolova
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Sofia , Sofia , Bulgaria.
authors.forename: Danka
authors.initials: D
authors.lastname: Obreshkova
keywords: Alzheimer's disease; avoidance learning; galantamine hydrobromide