title: The prevalence of acute kidney injury in neonates with birth asphyxia is higher in the Democratic Republic of Congo than in Western countries.
abstract: OBJECTIVE
  There is very little data on acute kidney injury in neonates in Africa. The aim of this study was to describe the frequency of acute kidney injury and the outcome in neonates admitted to hospital for asphyxia in the Democratic Republic of Congo.
  
  
  METHODS
  A descriptive study was conducted in the country's capital Kinshasa. Acute kidney injury was diagnosed within three days of life when the creatinine clearance was ≤16 mL/min/1.73 m².
  
  
  RESULTS
  Acute kidney injury occurred in 54.3% of the 35 neonates with severe perinatal asphyxia and 31.4% of the 35 neonates with moderate perinatal asphyxia, and this rate was higher than the prevalence reported in Western countries. Prerenal acute kidney injury occurred in 12 (40%) of the 30 neonates with acute kidney injury. The frequency of oliguria was significantly higher in neonates with severe perinatal asphyxia than moderate perinatal asphyxia (73.7% vs. 45.5%), and mortality was also higher in neonates with severe rather than moderate perinatal asphyxia (57.9% vs. 36.4%).
  
  
  CONCLUSIONS
  The prevalence of acute kidney injury was higher in asphyxiated patients in the Democratic Republic of Congo than in Western countries. It was also higher in neonates with severe rather than moderate perinatal asphyxia.
authors.affiliation: Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, Kinshasa, DRC.|Faculty of Medicine, University of Kinshasa, Kinshasa, DRC.|Departement of Pediatrics, Goma Provincial Hospital, Goma, DRC.
authors.forename: Sébastien Ngilima
authors.initials: SN
authors.lastname: Matata
authors.affiliation: Faculty of Medicine, University of Kinshasa, Kinshasa, DRC.|Division of Neonatology, Department of Pediatrics, University Hospital of Kinshasa, Kinshasa, DRC.
authors.forename: Emmanuel Dimbu
authors.initials: ED
authors.lastname: Nkidiaka
authors.affiliation: Division of Hemato-oncology and Nephrology, Department of Pediatrics, University Hospital of Kinshasa, Kinshasa, DRC.|Faculty of Medicine, University of Kinshasa, Kinshasa, DRC.
authors.forename: Michel Ntetani
authors.initials: MN
authors.lastname: Aloni
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology; D001238:Asphyxia Neonatorum / Q000150:complications / Q000453:epidemiology*; D015023:Democratic Republic of the Congo / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D011446:Prospective Studies
keywords: Acute kidney injury; Africa; Birth asphyxia; Neonates; The Democratic Republic of Congo