title: Nephroprotective potential of Graptophyllum pictum against renal injury induced by gentamicin.
abstract: OBJECTIVE
  To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats.
  
  
  METHODS
  Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum at 300, 150, 75 mg/kg, respectively. Nephroprotective activity was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), biochemical markers Glutathione (GSH), Glutathione-S Transferase(GST), Superoxide dismutase (SOD), Catalase (CAT), serum urea and creatinine levels.
  
  
  RESULTS
  Results obtained showed that gentamicin induced nephrotoxic rats exhibited lower activities of biochemical markers and raised levels of TBARS, serum creatinine and urea. Remarkably, after treatment with G. pictum extract, anomalous levels of biochemical markers, lipid peroxidation and serum creatinine were returned to normal.
  
  
  CONCLUSIONS
  The results propose that G. pictum has nephroprotective effects, and can be a promising natural source against gentamicin induced nephrotoxicity.
authors.affiliation: Department of Chemistry, ShriMadhwaVadiraja Institute of Technology and Management, Udupi- 574115, India.
authors.forename: Keloth Kaitheri
authors.initials: KK
authors.lastname: Srinivasan
authors.affiliation: Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576104, Karnataka, India.
authors.forename: Jessy Elizabeth
authors.initials: JE
authors.lastname: Mathew
authors.affiliation: Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576104, Karnataka, India.
authors.forename: Kerryn Joseph
authors.initials: KJ
authors.lastname: A D'Silva
authors.affiliation: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576104, Karnataka, India.
authors.forename: Richard
authors.initials: R
authors.lastname: Lobo
authors.affiliation: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576104, Karnataka, India.
authors.forename: Nimmy
authors.initials: N
authors.lastname: Kumar
keywords: Gentamicin; Glutathione; Graptophyllum pictum; Nephrotoxicity; Oxidativestress