title: Retinol-binding protein-4 and hs-CRP levels in patients with migraine.
abstract: Retinol-binding protein-4 (RBP4) and high-sensitivity C-reactive protein (hs-CRP) levels are associated with inflammation in patients with migraine. The release of proinflammatory cytokines during migraine results in recurrent sterile neurogenic inflammation. This study aimed to determine the correlation between RBP4 and hs-CRP levels, and migraine, which is considered an inflammatory disease. The study included 48 migraine patients and 40 age- and gender-matched controls. Migraine was diagnosed according to International Classification of Headache Disorders-II. The serum RBP4 level was measured using a commercial ELISA kit and hs-CRP was measured using an enzyme immunoassay test kit. The serum RBP4 level was significantly lower in the migraine patients than in the controls (P < 0.001), whereas the hs-CRP level was significantly higher in the migraine patients (P < 0.001). RBP4 and hs-CRP levels did not differ between the migraine patients with and without aura (P > 0.05). Migraine headache severity, frequency and duration were not correlated with serum RBP or hs-CRP levels (P > 0.05). The observed high hs-CRP level and low RBP4 level in migraine patients suggest that vitamin A might play a major role in the pathogenesis of migraine. It is known that inflammation is a key factor in many diseases. Additional research might result in a better understanding of the anti-inflammatory effects of vitamin A.
authors.affiliation: Department of Neurology, Bozok University Medical School, 66200, Yozgat, Turkey. drnermin27@hotmail.com.
authors.forename: Nermin
authors.initials: N
authors.lastname: Tanik
authors.affiliation: Department of Neurology, Bozok University Medical School, 66200, Yozgat, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Celikbilek
authors.affiliation: Department of Medical Biology, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Metin
authors.affiliation: Department of Biochemistry, Bozok University Medical School, Yozgat, Turkey.
authors.forename: Ayse Yesim
authors.initials: AY
authors.lastname: Gocmen
authors.affiliation: Department of Neurology, Bozok University Medical School, 66200, Yozgat, Turkey.
authors.forename: Levent Ertugrul
authors.initials: LE
authors.lastname: Inan
mesh_terms: D000293:Adolescent; D000328:Adult; D001774:Blood Chemical Analysis; D002097:C-Reactive Protein / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000097:blood*; D020326:Migraine without Aura / Q000097:blood*; D011446:Prospective Studies; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
chemical_list: C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D002097:C-Reactive Protein
keywords: High-sensitivity C-reactive protein; Migraine; Neurogenic inflammation; Retinol binding protein-4