title: Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl-, and Alkynylzinc Reagents with Heteroaryl Iodides.
abstract: Reported herein is an unprecedented ligand-free copper-catalyzed cross-coupling of alkyl-, aryl-, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 °C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
authors.forename: Surendra
authors.initials: S
authors.lastname: Thapa
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
authors.forename: Arjun
authors.initials: A
authors.lastname: Kafle
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Gurung
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
authors.forename: Adam
authors.initials: A
authors.lastname: Montoya
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA).
authors.forename: Patrick
authors.initials: P
authors.lastname: Riedel
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA). rgiri@unm.edu.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Giri
keywords: copper; cross-coupling; heterocycles; synthetic methods; zinc