title: Comparison between Radiological and Invasive Diagnostic Modalities in Diagnosis of Breast Cancer.
abstract: BACKGROUND
  Breast cancer is the most common cause of deaths of cancer in women. Nowadays, following completion of imaging methods, mainly fine needle aspiration biopsy (FNAB) and core biopsy methods have been used for establishing cytopathological diagnosis although discussions regarding superiority continue.
  
  
  METHODS
  Those with a complaint of "mass in breast" along with those diagnosed to have a mass as a result of routine physical examination among all patients applying to our clinic between 01.01.2009 and 31.12.2011 were retrospectively assessed. Totals of 146 and 64 patients with complete radiological observation who had undergone FNAB and core biopsies, respectively, were evaluated. Postoperative pathological results of patients of both groups receiving surgery were also taken into consideration. All results were compared in terms of false positivity/negativity, sensitivity/specifity, surgery types and distribution of postoperative results with regard to diagnoses along with those of malignant/benign masses with regard to quadrants determined.
  
  
  RESULTS
  Diagnostic malignancy power of mammographic BIRADS classification was 87.3%. However, the value was 75% in the core biopsy group. Sensitivity and specifity following comparison of FNAB and postoperative pathology results of those receiving surgery were 85.4% and 92.9% while they were 93.5% and 100% in the core biopsy group. Diagnostic malignancy power, calculated by determining AUC in ROC analysis, of FNAB was 89.1% while that of core biopsy was 96.7%.
  
  
  CONCLUSIONS
  It was shown that core biopsy is superior to FNAB in terms of sensitivity, specificity and accurate histopathological classification. However; quick, cheap and basic diagnosis by means of FNAB should not be ignored. Sensitivity of FNAB is rather high in experienced hands and furthermore it would be expected to be lower than with core biopsy.
authors.affiliation: Karakavak Family Medicine Center, Malatya, Turkey E-mail : gulcinozkann@yahoo.com.
authors.forename: Gulcin Ozkan
authors.initials: GO
authors.lastname: Onur
authors.forename: Ercument
authors.initials: E
authors.lastname: Tarcan
authors.forename: Asim
authors.initials: A
authors.lastname: Onur
authors.forename: Huseyin
authors.initials: H
authors.lastname: Can
authors.forename: Murat Kemal
authors.initials: MK
authors.lastname: Atahan
authors.forename: Seyran Ceri
authors.initials: SC
authors.lastname: Yigit
authors.forename: Fulya
authors.initials: F
authors.lastname: Cakalagaoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D044963:Biopsy, Fine-Needle; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis*; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D055815:Young Adult