title: Isotretinoin-induced skeletal hyperostosis.
abstract: We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severity of this condition appears to correlate with duration of therapy. Isotretinoin is a well-established treatment for severe acne. It is important for the rheumatologist be aware of this phenomenon when assessing young patients with musculoskeletal symptoms and evidence of radiological abnormalities.
authors.affiliation: Department of General Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000 Australia.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Graf
authors.affiliation: Rheumatology unit, The Queen Elizabeth Hospital, Woodville South, South Australia Australia.
authors.forename: Samuel L
authors.initials: SL
authors.lastname: Whittle