title: Clinicopathologic features of remnant gastric cancer over time following distal gastrectomy.
abstract: OBJECTIVE
  To investigate remnant gastric cancer (RGC) at various times after gastrectomy, and lay a foundation for the management of RGC.
  
  
  METHODS
  Sixty-five patients with RGC > 2 years and < 10 years after gastrectomy (RGC I) and forty-nine with RGC > 10 years after gastrectomy (RGC II) who underwent curative surgery were enrolled in the study. The clinicopathologic factors, surgical outcomes, and prognosis were compared between RGC I and RGC II.
  
  
  RESULTS
  There was no significant difference in surgical outcomes between RGC I and RGC II. For patients reconstructed with Billroth II, significantly more patients were RGC II compared with RGC (71.9% vs 21.2%, P < 0.001), and more RGC II patients had anastomotic site locations compared to RGC I (31.0% vs 56.3%, P = 0.038). The five-year survival rates for the patients with RGC I and RGC II were 37.6% and 47.9%, respectively, but no significant difference was observed. Borrmann type and tumor stage were confirmed to be independent prognostic factors in both groups.
  
  
  CONCLUSIONS
  RGC II is located on the anastomotic site in higher frequency and more cases develop after Billroth II reconstruction than RGC I.
authors.affiliation: De-Wei Zhang, Biao Dong, Zhen Li, Dong-Qiu Dai, Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.
authors.forename: De-Wei
authors.initials: DW
authors.lastname: Zhang
authors.affiliation: De-Wei Zhang, Biao Dong, Zhen Li, Dong-Qiu Dai, Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Dong
authors.affiliation: De-Wei Zhang, Biao Dong, Zhen Li, Dong-Qiu Dai, Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: De-Wei Zhang, Biao Dong, Zhen Li, Dong-Qiu Dai, Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China.
authors.forename: Dong-Qiu
authors.initials: DQ
authors.lastname: Dai
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000368:Aged; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects / Q000401:mortality; D005763:Gastroenterostomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Clinical pathology; Recurrence; Remnant gastric cancer; Survival