title: [The use of methotrexate for the treatment of sarcoidosis (data from a controlled prospective study)].
abstract: We estimated the effectiveness and safety of methotrexate monotherapy of sarcoidosis in 63 patients refractory to the previous treatment. Methotrexate was given weekly at a dose of 5-20 mg. 54% of the patients reported improvement of their condition. Parameters of spirogram and the ray picture improved in 63.2 and 54% of the cases respectively. Methotrexate proved safe and had to be discontinued only in 12.6% of the patients. It is concluded that methotrexate can be used at least in half of the cases as a safe alternative to systemic steroid therapy.
authors.forename: A A
authors.initials: AA
authors.lastname: Vizel
authors.forename: I Yu
authors.initials: IY
authors.lastname: Vzel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D011446:Prospective Studies; D012507:Sarcoidosis / Q000188:drug therapy*
chemical_list: D005493:Folic Acid Antagonists; D008727:Methotrexate