title: Enhanced pharmacological activity of vitamin B₁₂ and penicillin as nanoparticles.
abstract: Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120-180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical field.
authors.affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Inbar
authors.initials: I
authors.lastname: Yariv
authors.affiliation: Department of Chemistry, Kanbar Laboratory for Nanomaterials, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Anat
authors.initials: A
authors.lastname: Lipovsky
authors.affiliation: Department of Chemistry, Kanbar Laboratory for Nanomaterials, Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel ; Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Aharon
authors.initials: A
authors.lastname: Gedanken
authors.affiliation: Physics and Chemistry Department, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Rachel
authors.initials: R
authors.lastname: Lubart
authors.affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, Israel.
authors.forename: Dror
authors.initials: D
authors.lastname: Fixler
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010406:Penicillins / Q000737:chemistry / Q000494:pharmacology*; D013010:Sonication; D013211:Staphylococcus aureus / Q000187:drug effects; D014805:Vitamin B 12 / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D010406:Penicillins; D014805:Vitamin B 12
keywords: Penicillin; Vitamin B12; antibacterial; antioxidant; nanomaterials; sonochemistry