title: Estimation of oral leukoplakia treatment records in the research of the Department of Maxillofacial and Oral Surgery, Medical University of Gdansk.
abstract: BACKGROUND
  Oral leukoplakia (OL) is the most common potentially malignant lesion of the oral cavity.
  
  
  OBJECTIVE
  The purpose of the study was clinical and epidemiological analysis of patients with OL diagnosed and treated in the Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, comparison of effectiveness of treatment methods, defining whether van der Waal level of OL influences treatment effectiveness, correlation between localization of OL and treatment effectiveness, and defining the optimal OL therapeutic method.
  
  
  METHODS
  Among 55 911 patients diagnosed and treated in the Department in the years 1999-2009, 204 people with OL were selected (104 women, 100 men, average age: 58.1 years). Treatment and observation period of 6 months was completed by 178 (87.25%) patients. Seventy-four patients were treated with cream containing 0.05% tretinoin. Sixty-three patients underwent cryosurgery, and 41 surgery. Control visits were made in week 2, 4, 6 and 8 and 6 months after completed treatment.
  
  
  RESULTS
  Three hundred and twenty lesions of OL were diagnosed. According to van der Waal classification, the largest group of patients was classified into stage I and II. The percentage of totally cured patients was 90.07%. There were no statistic differences in effectiveness between surgical and cryosurgical treatment.
  
  
  CONCLUSIONS
  Evaluation of OL treatment methods depends on localization of the lesions and its stage of progression. The effectiveness of treatment with locally applied tretinoin is smaller in comparison to surgery and cryosurgery. It allows to reduce the number and size of OL lesions, what makes it possible to reduce the number of ablative procedures.
authors.affiliation: Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Adam Włodarkiewicz MD, PhD.
authors.forename: Anna
authors.initials: A
authors.lastname: Starzyńska
authors.affiliation: Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Adam Włodarkiewicz MD, PhD.
authors.forename: Anita
authors.initials: A
authors.lastname: Pawłowska
authors.affiliation: Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Adam Włodarkiewicz MD, PhD.
authors.forename: Dorota
authors.initials: D
authors.lastname: Renkielska
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Igor
authors.initials: I
authors.lastname: Michajłowski
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Michał
authors.initials: M
authors.lastname: Sobjanek
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Izabela
authors.initials: I
authors.lastname: Błażewicz
authors.affiliation: Department of Maxillofacial and Oral Surgery, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Adam Włodarkiewicz MD, PhD.
authors.forename: Adam
authors.initials: A
authors.lastname: Włodarkiewicz
keywords: cryosurgery; leukoplakia; surgical excision; treatment; tretinoin