title: Comparison of Arbekacin and Vancomycin in Treatment of Chronic Suppurative Otitis Media by Methicillin Resistant Staphylococcus aureus.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of ear infections. We attempted to evaluate the clinical usefulness of arbekacin in treating chronic suppurative otitis media (CSOM) by comparing its clinical efficacy and toxicity with those of vancomycin. Efficacy was classified according to bacterial elimination or bacteriologic failure and improved or failed clinical efficacy response. Ninety-five subjects were diagnosed with CSOM caused by MRSA. Twenty of these subjects were treated with arbekacin, and 36 with vancomycin. The bacteriological efficacy (bacterial elimination, arbekacin vs. vancomycin: 85.0% vs. 97.2%) and improved clinical efficacy (arbekacin vs. vancomycin; 90.0% vs. 97.2%) were not different between the two groups. However, the rate of complications was higher in the vancomycin group (33.3%) than in the arbekacin group (5.0%) (P=0.020). In addition, a total of 12 adverse reactions were observed in the vancomycin group; two for hepatotoxicity, one for nephrotoxicity, eight for leukopenia, two for skin rash, and one for drug fever. It is suggested that arbekacin be a good alternative drug to vancomycin in treatment of CSOM caused by MRSA.
authors.affiliation: Department of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Ji-Hee
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Preventive Medicine, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Ju-Hyung
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Microbiology & Immunology, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Chung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea. ; Department of Otolaryngology-Head and Neck Surgery, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Yong-Joo
authors.initials: YJ
authors.lastname: Yoon
authors.affiliation: Department of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Mi-Kyoung
authors.initials: MK
authors.lastname: Moon
authors.affiliation: Department of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Ju-Sin
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Pharmacy, Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Kyoung-Suk
authors.initials: KS
authors.lastname: Won
authors.affiliation: Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. ; Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea.
authors.forename: Chang-Seop
authors.identifier: 0000-0002-2897-2202
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002908:Chronic Disease; D003982:Dibekacin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008875:Middle Aged; D010035:Otitis Media, Suppurative / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D003982:Dibekacin; D014640:Vancomycin; C031986:arbekacin
keywords: Arbekacin; Methicillin-resistant Staphylococcus aureus; Otitis Media; Vancomycin