title: Genotoxic activity of the new pharmaceutical FS-1 in Salmonella/microsome test and mouse lymphoma L5178Y cells.
abstract: OBJECTIVE
  The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/antiviral drug FS-1.
  
  
  METHODS
  The drug was tested in TA98, TA100, TA102, TA1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested at concentrations up to 500 μg/plate and in mouse lymphoma cells up to 2,000 μg/ml.
  
  
  RESULTS
  In both test-systems in all experiments completely negative results were obtained although FS-1 was tested at maximum tolerated doses.
  
  
  CONCLUSIONS
  The drug is not genotoxic. This is advantageous because many antibacterial/antiviral drugs possess such activity.
authors.affiliation: Scientific Center for Anti-Infectious Drugs, Almaty, Kazakhstan.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ilin
authors.forename: Murat
authors.initials: M
authors.lastname: Kulmanov
authors.forename: Armen
authors.initials: A
authors.lastname: Nersesyan
authors.forename: Helga
authors.initials: H
authors.lastname: Stopper
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D007466:Iodophors / Q000633:toxicity*; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008861:Microsomes / Q000187:drug effects; D009152:Mutagenicity Tests; D011134:Polysaccharides / Q000633:toxicity*; D012475:Salmonella / Q000187:drug effects
chemical_list: D007466:Iodophors; D011134:Polysaccharides; C000599496:pharmaceutical FS-1