title: Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse.
abstract: A smart, tumor-trigged, controlled drug release using inorganic "caps" with CO3 (2-) functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, P. R. China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, P. R. China.
authors.forename: Ziming
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Science, University College London, London, WC1E 6AU, UK.
authors.forename: Lara
authors.initials: L
authors.lastname: Yildirimer
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, P. R. China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, P. R. China.
authors.forename: Zhi Yuan William
authors.initials: ZY
authors.lastname: Lin
authors.affiliation: Department of Chemistry, University of California, Berkeley, CA, 94720, USA.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Cao
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, P. R. China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Pan
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute Soochow University, 708 Renmin Road, Suzhou, Jiangsu, 215006, P. R. China.
authors.forename: Wenguo
authors.initials: W
authors.lastname: Cui
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000494:pharmacology; D065546:Drug Liberation; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D012008:Recurrence
chemical_list: D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D004317:Doxorubicin; D002119:Calcium Carbonate
keywords: cancer therapy; controlled release; drug delivery, electrospun fibers; inorganic caps; tumor-triggered