title: Acyclovir in pityriasis rosea: An observer-blind, randomized controlled trial of effectiveness, safety and tolerability.
abstract: BACKGROUND
  Pityriasis rosea (PR) is an acute inflammatory dermatosis. The association of human herpes virus 6 and 7 suggests the utility of use of antiviral agents in this disease.
  
  
  OBJECTIVE
  To evaluate the effectiveness and safety of acyclovir in the treatment of PR.
  
  
  METHODS
  An observer-blind, randomized (1:1), parallel group, add-on trial was conducted on 24 adult patients with PR. Subjects of both Group A and B received the standard of care in the form of cetirizine 10 mg OD and calamine. Group A in addition received acyclovir 400 mg tablets thrice daily for 7 days. Both groups were followed up for four consecutive weeks for assessment of effectiveness and adverse events.
  
  
  RESULTS
  Group A complained of significantly fewer new lesions than Group B (P = 0.046). A complete response was obtained in all patients of Group A and 83% patients of Group B at the end of the follow up period. There was significant reduction in both lesional score and pruritus at second week follow-up in Group A and third week follow-up in Group B (P < 0.05). Minor adverse effects were observed in both treatment arms.
  
  
  CONCLUSIONS
  Acyclovir offered rapid resolution of clinical severity of PR from second week onwards without significantly increased adverse events as compared to supportive therapy alone.
authors.affiliation: Department of Dermatology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Das
authors.affiliation: Department of Pharmacology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Sil
authors.affiliation: Department of Dermatology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Nilay Kanti
authors.initials: NK
authors.lastname: Das
authors.affiliation: Department of Dermatology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Kunal
authors.initials: K
authors.lastname: Roy
authors.affiliation: Department of Pharmacology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Amal Kanti
authors.initials: AK
authors.lastname: Das
authors.affiliation: Department of Dermatology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
authors.forename: Debabrata
authors.initials: D
authors.lastname: Bandyopadhyay
keywords: Acyclovir; cetirizine; pityriasis rosea