title: Elastography to assess the effect of varicoceles on testes: a prospective controlled study.
abstract: Varicoceles are the most common and treatable cause of male infertility. The pathophysiology of varicoceles primarily includes elevated temperature, adrenal hormone reflux, gonadotoxic metabolite reflux, altered testicular blood flow, antisperm antibody formation and oxidative stress. The diagnosis of a varicocele is mainly clinical. However, a Doppler ultrasound is used to obtain clinical data and to more accurately measure testicular size. Acoustic radiation force impulse (ARFI) is an additional technique to simultaneously show different areas with different densities in a colour-coded image and a B-mode or greyscale image. This can be used for structural analysis of testicular tissue and has become an additional method for detecting pathologic tissue alterations. We enrolled 30 patients who had clinically diagnosed with left varicoceles and male infertility (Group 1). All patients were evaluated by history taking, physical examination, a spermiogram and an endocrine profile. Thirty control patients (Group 2) were randomly chosen from patients who had applied to an andrology clinic for infertility; their physical examinations and laboratory results showed normal findings. Mean elastography results were significantly different between the groups, and significantly lower in patients who had varicoceles. The relationship between hormonal profiles and elastography parameters was calculated as statistically significant negative correlations between FSH and elasticity. Additionally, a negative correlation was determined between varicocele grade and elasticity of testes. In conclusion, our prospective study showed that ARFI imaging may be more useful than palpation for determining early damage of testicular structure by varicoceles.
authors.affiliation: Department of Urology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Dede
authors.affiliation: Department of Radiology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Teke
authors.affiliation: Department of Urology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Daggulli
authors.affiliation: Department of Urology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Utangaç
authors.affiliation: Department of Urology, Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Baş
authors.affiliation: Department of Urology, Dicle University School of Medicine, Diyarbakir, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Penbegül
mesh_terms: D000328:Adult; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000000981:diagnostic imaging* / Q000209:etiology; D008297:Male; D011446:Prospective Studies; D013737:Testis / Q000000981:diagnostic imaging*; D014646:Varicocele / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D055815:Young Adult
chemical_list: D005640:Follicle Stimulating Hormone
keywords: Elastography; scrotal ultrasound; varicocele