title: Ultra high resolution optical coherence tomography in Boston type I keratoprosthesis.
abstract: OBJECTIVE
  To evaluate the anterior keratoprosthesis-cornea interface in eyes with Boston type I keratoprosthesis (Kpro).
  
  
  METHODS
  In a prospective non-interventional study, patients with Boston type I Kpro underwent ultra-high resolution optical coherence tomography (UHR-OCT) evaluation. The images were used to measure and describe characteristics of the anterior keratoprosthesis-cornea interface, epithelial interaction at the keratoprosthesis edge and the keratoprosthesis-cornea interface gap.
  
  
  RESULTS
  Ten patients including 4 male and 6 female subjects with different preoperative diagnoses, i.e. 8 multiple corneal graft failures and 2 immunological ocular surface diseases, were studied. Mean age was 62.1 ± 20.0 (range, 33.0-83.0) years and mean interval between surgery and UHR-OCT evaluation was 15.2 ± 11.09 months. In eight patients, 360° epithelial growth over the peripheral edge of the Kpro was documented. We detected keratoprosthesis-cornea interface gap in three patients. One subject had developed postoperative endophthalmitis 8 months after surgery and the other two cases were among the high risk group according to the preoperative diagnosis. In one patient with severe ocular hypotony, the Kpro edge was inserted into the anterior stroma and covered with epithelium.
  
  
  CONCLUSIONS
  UHR-OCT showed that corneal epithelium covers the Kpro edge and seals the potential space between the Kpro and cornea in 80% of cases. The presence of a gap in the interface and lack of epithelial sealing around the Kpro edge might be associated with endophthalmitis.
authors.affiliation: Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Siamak
authors.initials: S
authors.lastname: Zarei-Ghanavati
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Betancurt
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
authors.forename: Alma Michelle
authors.initials: AM
authors.lastname: Mas
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miami, FL, USA.
authors.forename: Victor L
authors.initials: VL
authors.lastname: Perez
keywords: Anterior Segment OCT; Boston Type I Keratoprosthesis; Ultra High-resolution OCT