title: Serum cystatin C - marker of inflammation and cardiovascular morbidity in chronic kidney disease stages 1-4.
abstract: OBJECTIVE
  The aim of the research was to compare the relationship between inflammatory biomarkers and procoagulants with kidney function assessed by using cystatin C, serum creatinine, and eGFR and determine the sensitivity of cystatin C, serum creatinine and eGFR to total cardiovascular morbidity in patients with CKD stages 1-4.
  
  
  METHODS
  The research included 120 patients older than 18 years with CKD stages 1-4 monitored over a period of 24 months.
  
  
  RESULTS
  Serum cystatin C correlates with fibrinogen (p<0.01), serum albumin (p<0.01), D-dimer (p<0.05), antithrombin III (p<0.01) strongly in relation to the evaluation of kidney function based on serum creatinine and eGFR. By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p<0.05).
  
  
  CONCLUSIONS
  Serum cystatin C is more strongly correlated with some biomarkers (fibrinogen, serum albumin, D-dimer, antithrombin III), while simultaneously showing a stronger sensitivity in relation to total cardiovascular morbidity compared with the assessment of kidney function based on serum creatinine and eGFR.
authors.affiliation: Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Alma
authors.initials: A
authors.lastname: Muslimovic
authors.affiliation: Department of Nephrology, Dialysis and Kidney Transplantation, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Denijal
authors.initials: D
authors.lastname: Tulumovic
authors.affiliation: Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Senad
authors.initials: S
authors.lastname: Hasanspahic
authors.affiliation: Clinic of Nephrology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Aida
authors.initials: A
authors.lastname: Hamzic-Mehmedbasic
authors.affiliation: Institute for Occupational Medicine of Canton Sarajevo, Sarajevo, Bosnia and Herzegovina.
authors.forename: Ramajana
authors.initials: R
authors.lastname: Temimovi
keywords: cardiovascular morbidity; cystatin C; inflammatory biomarkers; procoagulants