title: Synovitis in a Patient with IgG4-related Disease.
abstract: A 71-year-old man was admitted to our department due to arthralgia and renal dysfunction. A physical examination disclosed swelling of the right shoulder and left wrist joints. Laboratory tests showed elevated serum IgG4 and creatinine levels, and magnetic resonance imaging of the wrist revealed bone erosion and synovitis. In addition, fluorodeoxyglucose positron emission tomography showed uptake in the submandibular glands, pancreas, kidneys, and affected joints and a renal biopsy revealed tubulointerstitial nephritis with the infiltration of IgG4+ plasma cells. The patient was subsequently diagnosed with IgG4-related disease (IgG4-RD) and successfully treated with corticosteroid therapy. This case suggests that erosive arthritis may occur in patients with IgG4-RD.
authors.affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Tomiyama
authors.forename: Ryu
authors.initials: R
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kamogawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shirota
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamichi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ishii
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007668:Kidney / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000473:pathology; D049268:Positron-Emission Tomography; D012782:Shoulder; D013585:Synovitis / Q000209:etiology*; D014953:Wrist
chemical_list: D007074:Immunoglobulin G; D003404:Creatinine