title: Cognitive impact of lacunar infarcts and white matter hyperintensity volume.
abstract: BACKGROUND
  Subcortical lacunar infarcts and white matter hyperintensities (WMH) are common neuroradiological findings, but few studies associate between these insults and cognition in a community-dwelling population.
  
  
  METHODS
  The Dallas Heart Study is a population-based initiative whose assessments included demographic and clinical findings including brain MRI and the Montreal Cognitive Assessment (MoCA). The presence and number of lacunes in subjects aged over 55 years were assessed by study physicians. The WMH volume was measured by an automated method. The association between the presence and number of lacunar infarcts and of WMH volume with the total MoCA score and subdomains was assessed using linear regression with adjustment for age, gender and self-reported ethnicity.
  
  
  RESULTS
  In 609 subjects with valid data, both the presence and the increasing number of lacunes were associated with lower MoCA scores, even after adjusting for demographic variables. The presence of lacunes was also associated with lower scores in the memory, executive and attention subdomains. The WMH volume was not significantly associated with the MoCA score.
  
  
  CONCLUSIONS
  The presence and increasing number of lacunes in midlife is associated with a lower performance in multiple domains of a cognitive screening measure after adjusting for demographic factors.
authors.affiliation: University of South Florida, Tampa, Fla., USA.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Warren
authors.affiliation: UT Southwestern Medical Center, Dallas, Tex., USA.
authors.forename: Myron F
authors.initials: MF
authors.lastname: Weiner
authors.affiliation: UT Southwestern Medical Center, Dallas, Tex., USA.
authors.forename: Heidi C
authors.initials: HC
authors.lastname: Rossetti
authors.affiliation: UT Southwestern Medical Center, Dallas, Tex., USA.
authors.forename: Roderick
authors.initials: R
authors.lastname: McColl
authors.affiliation: UT Southwestern Medical Center, Dallas, Tex., USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Peshock
authors.affiliation: UT Southwestern Medical Center, Dallas, Tex., USA.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: King
keywords: Cognition; Lacune; Magnetic resonance imaging; Memory; Montreal Cognitive Assessment; White matter hyperintensity