title: Glycosmisines A and B: isolation of two new carbazole-indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities.
abstract: Two unique carbazole-indole-type dimeric alkaloids, glycosmisines A (1) and B (2), have been isolated from the stems of Glycosmis pentaphylla and their structures are elucidated by 1D and 2D NMR analyses, and their cytotoxicity against the growth of three cancer cell lines (A549, HepG-2 and Huh-7 cells) in culture was investigated using an MTT assay. Compounds 1 and 2 exhibited significant levels of cytotoxicity against three human cancer cell lines, and these two compounds also induced apoptosis in the same cell lines, as evidenced by changes in the morphological features of cells treated with these compounds and their dose-dependent accumulation of a sub-G1 population.
authors.affiliation: College of Chemistry and Materials Sciences, South Central University for Nationalities, 182 Minyuan Road, Wuhan 430074, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Chu
authors.initials: C
authors.lastname: Tang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.forename: Shasha
authors.initials: S
authors.lastname: Mo
authors.forename: Sha
authors.initials: S
authors.lastname: Wang
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Yang
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Mei
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D018547:Plant Stems / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles; D007211:Indoles; C000605662:glycosmisine A; C000605666:glycosmisine B