title: Silica-based mesoporous nanobiomaterials as promoter of bone regeneration process.
abstract: Silica-based mesostructured nanomaterials have emerged as a full family of biomaterials with tremendous potential to address the requirements for the bone regeneration process. This review focuses on more recent advances in bone regeneration process based on silica-based mesoporous biomaterials during 2012 to January 2015. In this review, we describe application of silica-based mesoporous mesostructured nanomaterials (possessing pore sizes in the range 2-50 nm) for the bone regeneration process. We summarize the preparation methods, the effect of mesopore templates and composition on the mesopore-structure characteristics, and different forms of these materials, including particles, fibers, spheres, scaffolds, and composites. The effect of structural and textural properties of mesoporous materials on the development of new biomaterials for treatment of different bone pathologies such as infection, osteoporosis, cancer, and so forth is discussed. In addition, silica-based mesoporous bioactive glass, as a potential drug/growth factor carrier, is reviewed, which includes the composition-structure-drug delivery relationship and the functional effect on the antibacteria and tissue-stimulation properties. Also, application of different mesoporous materials on construction of 3D macroporous scaffolds for bone tissue engineering was disused. Finally, this review discusses the possibility of covalently grafting different osteoinductive agents to the silica-based mesoporous scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.
authors.affiliation: Department of Nanochemistry, Nano Technology Research Center, Urmia University, Urmia, Iran.|Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Shadjou
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hasanzadeh
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000494:pharmacology*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D012822:Silicon Dioxide
keywords: bone regeneration; bone tissue engineering; nanobiotechnology; osteogenic growth factors; silica-based mesoporous material