title: Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer.
abstract: BACKGROUND
  The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. The present study demonstrated that KK-LC-1 is expressed in gastric cancer.
  
  
  METHODS
  We analyzed the expression of KK-LC-1 and cancer/testis antigens (CTAs) in surgical specimens of 49 gastric carcinomas. The expression of KK-LC-1 and CTAs was assessed using reverse transcription-polymerase chain reaction.
  
  
  RESULTS
  KK-LC-1 expression was observed in gastric carcinomas. The number of lesions with expression of KK-LC-1, Melanoma antigen gene encoding-A1 (MAGE-A1), MAGE-A3 and New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) was 40 (81.6%), 17 (34.7%), 22 (44.9%) and 8 (16.3%) out of the 49 specimens, respectively.
  
  
  CONCLUSIONS
  KK-LC-1 should be categorized as a CTA. The frequency of KK-LC-1 expression was higher than that of the other CTAs. KK-LC-1 might be a useful target for immunotherapy and in diagnosis of gastric cancer.
authors.affiliation: Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan Division of Surgery, Kitasato University, Sagamihara, Kanagawa, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Shida
authors.affiliation: Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan Division of Surgery, Kitasato University, Sagamihara, Kanagawa, Japan.
authors.forename: Nobue
authors.initials: N
authors.lastname: Futawatari
authors.affiliation: Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Saitama, Japan fukuyam@insti.kitasato-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuyama
authors.affiliation: Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ichiki
authors.affiliation: Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Division of Surgery, Kitasato University Medical Center, Kitamoto, Saitama, Japan.
authors.forename: Yatsushi
authors.initials: Y
authors.lastname: Nishi
authors.affiliation: Division of Biomedical Research, Kitasato University Medical Center, Kitamoto, Saitama, Japan.
authors.forename: Noritada
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: Division of Pathology, Kitasato University Medical Center, Kitamoto, Saitama, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamazaki
authors.affiliation: Division of Surgery, Kitasato University, Sagamihara, Kanagawa, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D018395:CA-19-9 Antigen / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D058950:Melanoma-Specific Antigens / Q000096:biosynthesis; D008565:Membrane Proteins / Q000096:biosynthesis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D018395:CA-19-9 Antigen; C000600054:CT83 protein, human; C104948:CTAG1B protein, human; C072011:MAGEA1 protein, human; C072013:MAGEA3 protein, human; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins; D009363:Neoplasm Proteins
keywords: KK-LC-1; Kita-kyushu lung cancer antigen-1; cancer/testis antigen; gastric cancer