title: An update on new methods to synthesize cyclotetrapeptides.
abstract: Cyclotetrapeptides are important bioactive lead drug molecules that display a wide spectrum of pharmacological activities. However, the synthesis of cyclotetrapeptides from their linear precursors is challenging due to the highly constrained conformation required for cyclisation, thus hampering their progress to a clinical setting. This review provides an account of the reported methods used for the synthesis of cyclotetrapeptides.
authors.affiliation: Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.
authors.forename: Luis M
authors.initials: LM
authors.lastname: De Leon Rodriguez
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Weidkamp
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
mesh_terms: D000595:Amino Acid Sequence; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D010456:Peptides, Cyclic