title: Arterial hypotension and prerenal failure in an extremely preterm infant associated with oral sildenafil.
abstract: We report significant hypotension and prerenal failure in an extremely preterm infant following two doses of oral sildenafil that warranted discontinuation of the drug and treatment with inotropes. Blood pressure and urine output normalized after 24 h of withdrawal of the oral drug. Sildenafil should be used cautiously in extremely preterm infants early in the neonatal course, where there is limited data on its efficacy and safety.
authors.affiliation: Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, Perth, WA, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Balasubramanian
authors.affiliation: 1] Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, Perth, WA, Australia [2] Centre for Neonatal Research and Education, School of Paediatrics and Child Health University of Western Australia, Perth, WA, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Strunk
authors.affiliation: 1] Neonatal Clinical Care Unit, King Edward Memorial Hospital for Women, Perth, WA, Australia [2] Centre for Neonatal Research and Education, School of Paediatrics and Child Health University of Western Australia, Perth, WA, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Kohan
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced; D000284:Administration, Oral; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000628:therapy; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007668:Kidney / Q000098:blood supply; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy*; D000068677:Sildenafil Citrate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D000068677:Sildenafil Citrate