title: [Frontiers in Live Bone Imaging Researches. In vivo vascular imaging of thrombosis and thrombopoiesis].
abstract: In vivo imaging technique can elucidate dynamic molecular and cellular mechanisms in various fields. We applied two photon microscopy technique to living animals, and combined with light based cell manipulation system. We applied two photon microscopy technique to living animals, and combined with light based cell manipulation system. We elucidated the detailed cellular processes of thrombosis and thrombopoiesis in vivo. In this review, we introduce our recent findings of in vivo platelet activation, hemostasis and thrombopoiesis from bone marrow megakaryocytes.
authors.affiliation: Center for Molecular Medicine, Jichi Medical University, Japan./Department of Cardiovascular Medicine, the University of Tokyo TSBMI, the University of Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000502:physiology* / Q000648:ultrastructure*; D001854:Bone Marrow Cells / Q000502:physiology / Q000648:ultrastructure; D006410:Hematopoiesis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D051379:Mice; D036641:Microscopy, Fluorescence, Multiphoton; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends*; D010974:Platelet Aggregation / Q000502:physiology; D034061:Thrombopoiesis / Q000502:physiology*; D013927:Thrombosis / Q000473:pathology*