title: Lack of association between endothelial nitric oxide synthase gene polymorphisms with vasculitis: a meta-analysis.
abstract: OBJECTIVE
  We carried out this meta-analysis to evaluate the relationship between eNOS polymorphisms (G894T, T-786C, and intron-4ba) and vasculitis.
  
  
  METHODS
  We systematically searched PubMed, EMBASE and the Cochrane Library for related genetic association studies. The associations between the G894T, T-786C and intron 4ba polymorphisms of eNOS and vasculitis were conducted using the recessive model and the dominant model. Odds ratio (OR) with 95% confidence interval (CI) of each study were calculated. Cochran's Q test was used to evaluate the between-study heterogeneity.
  
  
  RESULTS
  A total of 17 studies were included in our study. Twelve studies with 1213 cases and 1499 controls were included in the G894T association study. The pooled OR of T allele compared to C allele in recessive model was 1.19 (95%CI: 0.76-1.87, p=0.44) in dominant model and was 1.25 (95%CI: 0.70-2.23, p=0.56) in recessive model, respectively. Nine studies with 910 cases and 1062 controls were included in the intron -4ba association study. The pooled OR of b allele compared with intron-4a allele was 1.02 (95%CI: 0.60-1.72, p=0.95) in dominant model and was 0.84 (95%CI: 0.58-1.21, p=0.35) in recessive model. No association was found between T-786C and vasculitis in both the dominant 0.81(95% CI: 0.59-1.11, p=0.19) and recessive model 0.87 (95%CI: 0.55-1.36, p=0.53).
  
  
  CONCLUSIONS
  The eNOS G894T, T-786C and intron4ba polymorphisms are not associated with vasculitis.
authors.affiliation: Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Cardiac Surgery I, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: M
authors.initials: M
authors.lastname: Xiong
authors.affiliation: Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: B
authors.initials: B
authors.lastname: Tang
mesh_terms: D006801:Humans; D007438:Introns / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D014657:Vasculitis / Q000235:genetics*
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III