title: [Studies on association of HSL repeat polymorphism and aerobic endurance].
abstract: OBJECTIVE
  To investigate the relationship between hormone sensitive lipase (HSL) gene polymorphism and aerobic endurance.
  
  
  METHODS
  The (CA)n repeats polymorphism genotypes in HSL intro 6 of 123 outstanding long distance runners and 127 controls of Han nationality in northern China were analyzed by PCR and Fluorescence labeled STR-genescan. Repeat polymorphisms were grouped according to segmentation point and alleles were divided into long or short chains. Chi-square test was used to analyze the frequency difference of allelic and genotypic between athlete and control groups.
  
  
  RESULTS
  (CA) n repeats polymorphism in HSL gene was total of 9 different repeat number of alleles, which composed of 25 different genotypes. The chi-square test result showed that when compared short and long chain alleles split by 4, there was a significant difference (P <0.05) of genotype distribution in 5/10 km group compared with control. Compared the rest groups with control, there was no significant difference.
  
  
  CONCLUSIONS
  Compared short and long chain alleles split by 4, the LL genotype of (CA)n of HSL was associated with aerobic endurance and it might be a molecular marker of elite 5/10 km long distance runners.
authors.forename: Xiao-hui
authors.initials: XH
authors.lastname: Xia
authors.forename: Hui-yun
authors.initials: HY
authors.lastname: Xia
authors.forename: Jie
authors.initials: J
authors.lastname: Guo
authors.forename: Kang-chao
authors.initials: KC
authors.lastname: Liu
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000483:Alleles; D002681:China; D005006:Ethnicity; D005838:Genotype; D006801:Humans; D010807:Physical Endurance; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D002787:Sterol Esterase / Q000235:genetics*
chemical_list: D002787:Sterol Esterase