title: Regulatory T Cells in Obesity.
abstract: The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.
authors.affiliation: Department of Pediatrics and Endocrinology, Medical University of Warsaw, 24 Marszalkowska St., 00-576, Warsaw, Poland, anna.kucharska@litewska.edu.pl.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Kucharska
authors.forename: Beata
authors.initials: B
authors.lastname: Pyrżak
authors.forename: Urszula
authors.initials: U
authors.lastname: Demkow
mesh_terms: D052242:Adiponectin / Q000502:physiology; D000818:Animals; D006801:Humans; D050152:Intra-Abdominal Fat / Q000276:immunology; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000209:etiology / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D052242:Adiponectin; D020738:Leptin