title: Predicting lympho-vascular space invasion in endometrial cancers with mucinous carcinomatous components.
abstract: OBJECTIVE
  To determine the predictors of lympho-vascular space invasion (LVSI) in endometrial cancers which contain mucinous carcinomatous histology.
  
  
  METHODS
  Clinical and histopathological data of endometrial carcinomas with a mucinous carcinomatous component diagnosed between January 2007 and January 2014 at the Gynecologic Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively.
  
  
  RESULTS
  Twelve patients (25.5%) were positive for LVSI and 35 (74.5%) patients were negative. Patients with LVSI were mostly staged higher than 1A. Mean age, BMI and parity were not significantly different between patient groups. Larger tumor diameter (≥2 cm) (p=0.04) and elevated Ca125 and Ca-19.9 (p=0.01) levels were significant for predicting LVSI. We also found >1/2 myometrial invasion (p<0.001), cervical stromal involvement (p=0.002) and higher grade (2-3) (p=0.001) significant for predicting LVSI. In multivariate analysis we found only grade significant for predicting LVSI.
  
  
  CONCLUSIONS
  Especially grade of tumor is a crucial factor for determining LVSI in endometrial cancers with mucinous carcinomatous components.
authors.affiliation: Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital, Ankara, Turkey E-mail : ilkerselcukmd@hotmail.com.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Ilker
authors.forename: Cetinkaya
authors.initials: C
authors.lastname: Nilufer
authors.forename: Cuylan Zeliha
authors.initials: CZ
authors.lastname: Firat
authors.forename: Ozdal
authors.initials: O
authors.lastname: Bulent
authors.forename: Bayramoglu
authors.initials: B
authors.lastname: Hatice
authors.forename: Gungor
authors.initials: G
authors.lastname: Tayfun
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000097:blood / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000097:blood; D001808:Blood Vessels / Q000473:pathology*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000473:pathology*; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins