title: Regional differences in perivascular adipose tissue impacting vascular homeostasis.
abstract: Perivascular adipose tissue (PVAT) releases several important vasoactive factors with physiological and pathophysiological paracrine effects. A large body of evidence suggests regional phenotypic and functional differences among PVAT depots, depending on the specific vascular bed or different regions in the vascular bed where the PVAT is located. These non-uniform and separate PVATs exert various paracrine effects on vascular structure and function that largely impact disease states, such as endothelial dysfunction, atherosclerosis, or insulin resistance. This emerging view of PVAT function requires considering heterogeneous PVAT as a specialized organ that can differentially regulate vascular function depending on its anatomical location. In this context, the adipose-vascular axis may represent a novel target for pharmacological intervention in vasculopathy in cardiometabolic disorders.
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, 28668 Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Gil-Ortega
authors.affiliation: Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, 28668 Madrid, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Somoza
authors.affiliation: Institute of Vascular Medicine, Chinese University of Hong Kong, 20001 Hong Kong, China; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 20001 Hong Kong, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Nephrology and Intensive Care, Experimental and Clinical Research Center (ECRC), Charité Campus Virchow, 13125 Berlin, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Gollasch
authors.affiliation: Instituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain. Electronic address: marisolf@farm.ucm.es.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Fernández-Alfonso
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D012084:Renin-Angiotensin System