title: [Influence of silver and titanium dioxide nanoparticles on the expression of genes of biomarkers of inflammatory responses and apoptosis].
abstract: In order to evaluate the toxic effect of silver (AgNP) and titanium dioxide (TiO2) nanoparticles their influence on the expression of genes of biomarkers of inflammatory responses and apoptosis in human lymphocytes was studied. An increase in the IL-6, IL-8, TNF-α and p53 genes expression in the concentration range of silver and titanium dioxide nanoparticles of 10-40 μk g/ml was found. Increased expression of IL-6, IL-8, TNF-α and p53 genes under the nanoparticles action indicates the stimulation of the immune system and of apoptosis, respectively.
authors.forename: L A
authors.initials: LA
authors.lastname: Baranova
authors.forename: E V
authors.initials: EV
authors.lastname: Zhornik
authors.forename: I D
authors.initials: ID
authors.lastname: Volotovski
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D015850:Interleukin-6 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000096:biosynthesis; D053758:Nanoparticles / Q000008:administration & dosage / Q000009:adverse effects; D012834:Silver / Q000009:adverse effects / Q000494:pharmacology; D014025:Titanium / Q000494:pharmacology / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D016209:Interleukin-8; C495901:TP53 protein, human; D014409:Tumor Necrosis Factor-alpha; D016159:Tumor Suppressor Protein p53; C009495:titanium dioxide; D012834:Silver; D014025:Titanium