title: IL-17 cytokines in immunity and inflammation.
abstract: Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.
authors.affiliation: Tsinghua University School of Medicine , Beijing 100084, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.affiliation: Tsinghua University School of Medicine , Beijing 100084, China ; MD Anderson Cancer Center , Houston, TX 77054, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
keywords: IL-17 family cytokines; T helper 17; infection; inflammatory diseases