title: Determinants of optical coherence tomography-derived minimum neuroretinal rim width in a normal Chinese population.
abstract: OBJECTIVE
  To characterize an optical coherence tomography (OCT)-derived parameter, Bruch's membrane opening-minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects.
  
  
  METHODS
  Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from the BMO points to the ILM. Associations of BMO-MRW with demographic and clinical parameters were evaluated using marginal general estimating equations analysis.
  
  
  RESULTS
  There was a slight preponderance of male subjects (50.9%), with a mean age of 54.8 ± 7.63 years. Mean BMO-MRW was 304.67 ± 58.96 μm (range, 173.32-529.23 μm), which was highly associated with OCT-derived disc area (DA) (β = -91.78, P < 0.001) and rim area (RA) (β = 194.31, P < 0.001), followed by spherical refractive error (SRE) (β = -2.23, P = 0.02) and retinal nerve fiber layer (RNFL) thickness (β = 0.5, P = 0.04), after adjusting for the associated factors such as age, sex, intraocular pressure (IOP), and vertical cup-disc ratio (VCDR).
  
  
  CONCLUSIONS
  Disc area and RA had the strongest association with BMO-MRW, followed by SRE and RNFL thickness. The availability of this normative database will facilitate optic nerve head assessment using the BMO-MRW parameter in Chinese subjects.
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
authors.forename: Tin A
authors.initials: TA
authors.lastname: Tun
authors.affiliation: Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 3Department of Ophthalmology, National University Health System, Singapore.
authors.forename: Chen-Hsin
authors.initials: CH
authors.lastname: Sun
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 4Department of Ophthalmology, Yong Loo Lin School of Medicine.
authors.forename: Mani
authors.initials: M
authors.lastname: Baskaran
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 5In Vivo Biomechanics Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore.
authors.forename: Michael J A
authors.initials: MJ
authors.lastname: Girard
authors.affiliation: Cardinal Santos Medical Center, Metro Manila, Philippines.
authors.forename: John Mark S
authors.initials: JM
authors.lastname: de Leon
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 4Department of Ophthalmology, Yong Loo Lin School of Medicine.
authors.forename: Ching-Yu
authors.initials: CY
authors.lastname: Cheng
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore.
authors.forename: Hla M
authors.initials: HM
authors.lastname: Htoon
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 4Department of Ophthalmology, Yong Loo Lin School of Medicine.
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 2Duke-National University of Singapore (NUS) Graduate Medical School, National University of Singapore, Singapore 4Department of Ophthalmology, Yong Loo Lin School of Medicine.
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
authors.affiliation: Singapore Eye Research Institute and Singapore National Eye Centre, Singapore 7National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Strouthidis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001485:Basement Membrane / Q000033:anatomy & histology; D016570:Bruch Membrane / Q000033:anatomy & histology; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*