title: Climate change influences on the annual onset of Lyme disease in the United States.
abstract: Lyme disease is the most commonly reported vector-borne illness in the United States. Lyme disease occurrence is highly seasonal and the annual springtime onset of cases is modulated by meteorological conditions in preceding months. A meteorological-based empirical model for Lyme disease onset week in the United States is driven with downscaled simulations from five global climate models and four greenhouse gas emissions scenarios to project the impacts of 21st century climate change on the annual onset week of Lyme disease. Projections are made individually and collectively for the 12 eastern States where >90% of cases occur. The national average annual onset week of Lyme disease is projected to become 0.4-0.5 weeks earlier for 2025-2040 (p<0.05), and 0.7-1.9 weeks earlier for 2065-2080 (p<0.01), with the largest shifts for scenarios with the highest greenhouse gas emissions. The more southerly mid-Atlantic States exhibit larger shifts (1.0-3.5 weeks) compared to the Northeastern and upper Midwestern States (0.2-2.3 weeks) by 2065-2080. Winter and spring temperature increases primarily cause the earlier onset. Greater spring precipitation and changes in humidity partially counteract the temperature effects. The model does not account for the possibility that abrupt shifts in the life cycle of Ixodes scapularis, the primary vector of the Lyme disease spirochete Borrelia burgdorferi in the eastern United States, may alter the disease transmission cycle in unforeseen ways. The results suggest 21st century climate change will make environmental conditions suitable for earlier annual onset of Lyme disease cases in the United States with possible implications for the timing of public health interventions.
authors.affiliation: Research Applications Laboratory, National Center for Atmospheric Research, 3090 Center Green Dr., Boulder, CO 80301, USA. Electronic address: monaghan@ucar.edu.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Monaghan
authors.affiliation: Johns Hopkins School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address: semoore@jhsph.edu.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Moore
authors.affiliation: Research Applications Laboratory, National Center for Atmospheric Research, 3090 Center Green Dr., Boulder, CO 80301, USA. Electronic address: ksampson@ucar.edu.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Sampson
authors.affiliation: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd., Fort Collins, CO 80522, USA. Electronic address: cbb0@cdc.gov.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Beard
authors.affiliation: Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd., Fort Collins, CO 80522, USA. Electronic address: dyn2@cdc.gov.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Eisen
mesh_terms: D057231:Climate Change; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis* / Q000453:epidemiology*; D011159:Population Surveillance; D014481:United States / Q000453:epidemiology
keywords: Borrelia burgdorferi; Climate change; Ixodes scapularis; Lyme disease