title: Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders.
abstract: Symptomatic distresses associated with common ophthalmic infections and their persistence, have remained a tribulation with repeated occurrences. Although being a directly accessible organ, traditional therapeutic strategies exhibiting seemingly fruitful outcome in treatment and prognosis of eye disorders call for improvement in disease intervention. This is due to frequent challenges presented by the ophthalmic environment. Contemporary research has addressed these challenges by applying nanotechnology as a central concept in designing more proficient diagnostic and therapeutic systems for eye ailments. Within such nanosystems (dendrimers, aptamers, metal nanoparticles, etc.), bioactive agents, drugs and genetic materials can be entrapped and these form the key elements that act at the biomolecular stage and bestow a high level of efficacy towards eradication of disease causatives and specificity for recognition and capture aiding diagnostic processes. In the current review, we present researched and patented nanocentric technologies as promising tools in detection and treatment of ophthalmic ailments.
authors.forename: Swati
authors.initials: S
authors.lastname: Vyas
authors.forename: Pratik
authors.initials: P
authors.lastname: Kakade
authors.forename: Manasi
authors.initials: M
authors.lastname: Chogale
authors.forename: John
authors.initials: J
authors.lastname: Disouza
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai - 400019, Maharashtra, India. vbp_muict@yahoo.co.in.
authors.forename: Vandana
authors.initials: V
authors.lastname: Patravale
mesh_terms: D005128:Eye Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D009885:Ophthalmology / Q000379:methods*