title: Fatal intoxication caused by the application of the multiple transdermals patchs of fentanyl.
abstract: Fentanyl (N-phenyl-N-(1-2-phenylethyl-4-piperidyl)propanamide) is a potent synthetic narcotic analgesic. He has an analgesic effect 100 times greater than that of morphine. The use of transdermal fentanyl delivrery systems has increased over recent years especially in patients with chronic pain who are already treated with high doses of morphine or it is derivate. However, many cases of fentanyl intoxication through a variety of transderrmal systems have been reported. This paper reports a fatality due to excessive administered Fentanyl Sandoz® Matrix 50 µg/h transdermal therapeutic systems.
authors.affiliation: Pôle Anesthésie-Réanimation, Hôpital Militaire Avicenne, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, 40010 Marrakech, Maroc.
authors.forename: Issam
authors.initials: I
authors.lastname: Serghini
authors.affiliation: Pôle Anesthésie-Réanimation, Hôpital Militaire Avicenne, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, 40010 Marrakech, Maroc.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Qamouss
authors.affiliation: Pôle Anesthésie-Réanimation, Hôpital Militaire Avicenne, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, 40010 Marrakech, Maroc.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Zoubir
authors.affiliation: Pôle Anesthésie-Réanimation, Hôpital Militaire Avicenne, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, 40010 Marrakech, Maroc.
authors.forename: Jaafar Salim
authors.initials: JS
authors.lastname: Lalaoui
authors.affiliation: Pôle Anesthésie-Réanimation, Hôpital Militaire Avicenne, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, 40010 Marrakech, Maroc.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Boughalem
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000506:poisoning*; D059350:Chronic Pain / Q000188:drug therapy; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000473:pathology*; D000067490:Prescription Drug Overuse / Q000009:adverse effects; D012216:Rheumatic Diseases / Q000188:drug therapy
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl
keywords: Fentanyl; fatal intoxication; respiratory insufficiency; transdermal patch