title: Silicon oxide based materials for controlled release in orthopedic procedures.
abstract: By virtue of excellent tissue responses in bone tissue, silicon oxide (silica) based materials have been used for bone tissue engineering. Creating nanoscale porosity within silica based materials expands their applications into the realm of controlled release area. This additional benefit of silica based materials widens their application in the orthopedic fields in a major way. This review discusses the various chemical and physical forms of silica based controlled release materials, the release mechanisms, the applications in orthopedic procedures and their overall biocompatibility.
authors.affiliation: Center for Bioactive Materials and Tissue Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Haibo
authors.initials: H
authors.lastname: Qu
authors.affiliation: Center for Bioactive Materials and Tissue Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharyya
authors.affiliation: Center for Bioactive Materials and Tissue Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: ducheyne@seas.upenn.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Ducheyne
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D064420:Drug-Related Side Effects and Adverse Reactions; D005782:Gels / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles; D019637:Orthopedic Procedures / Q000379:methods*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005782:Gels; D012822:Silicon Dioxide
keywords: Bone; Controlled release; Silica