title: Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management.
abstract: Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease. The pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management of BCC will be discussed in this review.
authors.affiliation: Department of Dermatology, Yale School of Medicine, New Haven, Connecticut ; Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Marzuka
authors.affiliation: Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.
authors.forename: Samuel E
authors.initials: SE
authors.lastname: Book
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D019090:Case Management / Q000458:organization & administration*; D003131:Combined Modality Therapy / Q000379:methods; D003646:Debridement / Q000379:methods; D004781:Environmental Exposure / Q000706:statistics & numerical data; D006801:Humans; D015580:Mohs Surgery / Q000379:methods; D015995:Prevalence; D012307:Risk Factors; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D013472:Sunlight
chemical_list: D000970:Antineoplastic Agents
keywords: BCC; ED&C; Mohs surgery; basal cell carcinoma; electrodesiccation and curettage; surgical excision