title: Study of the water structure in poly(methyl methacrylate-block-2-hydroxyethyl methacrylate) and its relationship to platelet adhesion on the copolymer surface.
abstract: The water structure and platelet compatibility of poly(methyl methacrylate (MMA)-block-2-hydroxyethyl methacrylate (HEMA)) were investigated. The molecular weight (Mn) of the polyHEMA segment was kept constant (average: 9600), while the Mn of the polyMMA segment was varied from 1340 to 7390. The equilibrium water content of the copolymers was found to be mainly governed by the HEMA content. The water structure in the copolymers was characterized in terms of the amounts of non-freezing and freezing water (abbreviated as Wnf and Wfz, respectively) using differential scanning calorimetry. It was found that the Wnf for the copolymers were higher than those estimated from the Wnf for the HEMA and MMA homopolymers and that the amount of excess non-freezing water depended on the polyMMA segment length. In addition, X-ray diffraction analysis revealed that some of the copolymers had cold-crystallizable water. These facts suggested that the polyMMA segments were involved in determining the water structures in the copolymers. Furthermore, the platelet compatibility of the copolymers was improved as compared to that of the HEMA homopolymer. It was therefore concluded that the platelet compatibility of the copolymer was related to the amount of excess non-freezing water.
authors.affiliation: a Department of Bio-Medical Engineering, School of Engineering , Tokai University , Shimokasuya 143, Isehara , Kanagawa 259-1193 , Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Mochizuki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Namiki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nishimori
authors.forename: Haruki
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D005615:Freezing; D006801:Humans; D008422:Materials Testing; D008768:Methylmethacrylates / Q000737:chemistry* / Q000494:pharmacology*; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D008768:Methylmethacrylates; D014867:Water; D011102:Polyhydroxyethyl Methacrylate; C040206:HTR composite
keywords: HEMA-based block copolymer; differential scanning calorimetry; non-freezing water; platelet compatibility; water structure