title: Adrenocortical carcinoma.
abstract: Recent developments in the treatment of adrenocortical carcinoma (ACC) include diagnostic and prognostic risk stratification algorithms, increasing evidence of the impact of historical therapies on overall survival, and emerging targets from integrated epigenomic and genomic analyses. Advances include proper clinical and molecular characterization of all patients with ACC, standardization of proliferative index analyses, referral of these patients to large cancer referral centers at the time of first surgery, and development of new trials in patients with well-characterized ACC. Networking and progress in the molecular characterization of ACC constitute the basis for significant future therapeutic breakthroughs.
authors.affiliation: Département de Médecine, Gustave Roussy, 114, rue Édouard-Vaillant, Paris South University, Villejuif Cedex 94805, France; Département de Nucléaire et de Cancérologie Endocrinienne, Gustave Roussy, 114, rue Édouard-Vaillant, Paris South University, Villejuif Cedex 94805, France; Faculté de Médecine, INSERM UMR 1185, 63 rue Gabriel Péri, F-94276 Le Kremlin-Bicêtre, Université Paris Sud, Paris, France. Electronic address: eric.baudin@gustaveroussy.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Baudin
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D000315:Adrenalectomy; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008939:Mitotane / Q000627:therapeutic use*; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane
keywords: Adrenocortical carcinoma; Chemotherapy; Metastasis; Mitotane; Predictors; Prognosis; Surrogate; Survival