title: [Frontiers in Live Bone Imaging Researches. In vivo imaging of immune tissues].
abstract: In vivo imaging analysis of the immune tissues, especially secondary lymphoid tissues such as lymph nodes, has greatly increased our understanding of how immune responses are promoted and regulated by immune cell trafficking. Recently, in vivo tracking of follicular helper T (Tfh) cells, a vital T cell subset for B cell responses to produce antibodies, by imaging analysis and light-induced cell labeling not only revealed their migration dynamics, but also provided new insights into how Tfh cells may be involved in the generation of immunological memory.
authors.affiliation: Lab for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Japan.
authors.forename: Takaharu
authors.initials: T
authors.lastname: Okada
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D002465:Cell Movement; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D036641:Microscopy, Fluorescence, Multiphoton; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends*; D049349:Receptors, Lysosphingolipid / Q000502:physiology; D000081025:Sphingosine-1-Phosphate Receptors; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000648:ultrastructure*
chemical_list: D049349:Receptors, Lysosphingolipid; C477522:S1PR2 protein, human; D000081025:Sphingosine-1-Phosphate Receptors