title: Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients.
abstract: As the most common NK/T-cell lymphoma in Asian countries, extranodal NK/T-cell lymphoma, nasal type (ENKTL), has unique clinical features and a strong association with Epstein-Barr virus (EBV). In order to gain a preliminary understanding of the relationship between ENKTL and EBV, we performed genotypic analysis of EBV and investigated LMP1 expression in extranodal NK/T-cell lymphoma. Our study shows that ENKTL is an EBV-associated malignancy and that A, C and F are the predominant EBV genotypes in northern China. LMP1 expression is stronger in extranasal sites than nasal sites, and the expression level is strongly correlated to ENKTL and may play an important role in the development of ENKTL.
authors.affiliation: Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao, 266021, China.
authors.forename: Haijuan
authors.initials: H
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xing
authors.forename: Chengquan
authors.initials: C
authors.lastname: Zhao
authors.forename: Bing
authors.initials: B
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D005260:Female; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014763:Viral Matrix Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins