title: Emotional dysfunctions in neurodegenerative diseases.
abstract: Neurodegenerative diseases are characterized primarily by motor signs but are also accompanied by emotional disturbances. Because of the limited knowledge about these dysfunctions, this Review provides an overview of emotional competencies in Huntington's disease (HD), Parkinson's disease (PD), and multiple sclerosis (MS), with a focus on emotion recognition, emotion regulation, and depression. Most studies indicate facial emotion recognition deficits in HD and PD, whereas data for MS are inconsistent. On a neural level, dysfunctions of amygdala and striatum, among others, have been linked to these impairments. These dysfunctions also tap brain regions that are part of the emotion regulation network, suggesting problems in this competency, too. Research points to dysfunctional emotion regulation in MS, whereas findings for PD and HD are missing. The high prevalence of depression in all three disorders emphasizes the need for effective therapies. Research on emotional disturbances might improve treatment, thereby increasing patients' and caregivers' well-being.
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen, 52074, Aachen, Germany.
authors.forename: Leonie A K
authors.initials: LA
authors.lastname: Löffler
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen, 52074, Aachen, Germany.|JARA-Translational Brain Medicine, 52074, Aachen, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Radke
authors.affiliation: Department of Education and Psychology, Freie Universität Berlin, 14195, Berlin, Germany.
authors.forename: Carmen
authors.initials: C
authors.lastname: Morawetz
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, RWTH Aachen, 52074, Aachen, Germany.|JARA-Translational Brain Medicine, 52074, Aachen, Germany.|Institute for Neuroscience and Medicine (INM-1), Research Center Jülich, 52425, Jülich, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Derntl
mesh_terms: D000342:Affective Symptoms / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000503:physiopathology / Q000523:psychology*
keywords: Huntington's disease; Parkinson's disease; depression; emotion recognition; emotion regulation; multiple sclerosis