title: Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl- 1H-benzimidazole derivatives.
abstract: A series of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazoles (5-14) were synthesized and evaluated for their in vitro antiproliferative activities against the human leukemia cell line HL-60. Compounds 5-7 and 10-12 exhibited potent antiproliferative activities against this cell line. The quantitative analysis of apoptosis by flow cytometry demonstrated that the percentages of apoptotic HL-60 cells treated with compounds 5 and 10-12 were significantly higher than in the control.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Alp
authors.forename: A Selen
authors.initials: AS
authors.lastname: Gurkan-Alp
authors.forename: Tulin
authors.initials: T
authors.lastname: Ozkan
authors.forename: Asuman
authors.initials: A
authors.lastname: Sunguroglu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans
chemical_list: D001562:Benzimidazoles; C031000:benzimidazole