title: Synthesis of Spirocyclic Pyrazolones by Oxidative C-N Bond Formation.
abstract: The two-step synthesis of spirocyclic pyrazolone derivatives from simple and commercially available reagents is described. The unusual reaction of 1,3-dicarbonyls with hydrazines and an iodine-mediated oxidative carbon-nitrogen bond formation, joined in a two-step, one-pot reaction, allows the straightforward synthesis of these spirocycles.
authors.affiliation: Centro de Investigación Lilly S.A., Avda. de la Industria, 30, Alcobendas, Madrid 28108, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Agejas
authors.affiliation: Centro de Investigación Lilly S.A., Avda. de la Industria, 30, Alcobendas, Madrid 28108, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Ortega