title: The nanoscale organization of signaling domains at the plasma membrane.
abstract: In this chapter, we present an overview of the role of the nanoscale organization of signaling domains in regulating key cellular processes. In particular, we illustrate the importance of protein and lipid nanodomains as triggers and mediators of cell signaling. As particular examples, we summarize the state of the art of understanding the role of nanodomains in the mounting of an immune response, cellular adhesion, intercellular communication, and cell proliferation. Thus, this chapter underlines the essential role the nanoscale organization of key signaling proteins and lipid domains. We will also see how nanodomains play an important role in the lifecycle of many pathogens relevant to human disease and therefore illustrate how these structures may become future therapeutic targets.
authors.affiliation: Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
authors.forename: Juliette
authors.initials: J
authors.lastname: Griffié
authors.affiliation: Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
authors.forename: Garth
authors.initials: G
authors.lastname: Burn
authors.affiliation: Department of Physics and Randall Division of Cell and Molecular Biophysics, King's College London, London, UK.
authors.forename: Dylan M
authors.initials: DM
authors.lastname: Owen
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D002462:Cell Membrane / Q000378:metabolism*; D049109:Cell Proliferation; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity; D008563:Membrane Lipids / Q000378:metabolism*; D021962:Membrane Microdomains / Q000378:metabolism*; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000639:trends; D036103:Nanotechnology; D015398:Signal Transduction
chemical_list: D008563:Membrane Lipids
keywords: Cluster; HIV; Immune response; Nanodomains; Neuron; Signaling; Synapse; Vesicles; Virus