title: Incidence of Adverse Events during Continuous Renal Replacement Therapy.
abstract: OBJECTIVE
  The incidence of adverse events (AEs) in adults who receive continuous renal replacement therapy (CRRT) is unknown. We report the incidence of mechanical, metabolic, and hemodynamic CRRT AEs.
  
  
  METHODS
  This is a retrospective study of all consecutive adult patients (≥18 years) who underwent CRRT from January 1, 2007 to December 31, 2009.
  
  
  RESULTS
  Out of 595 patients who underwent CRRT, 366 (62%) were male and 500 (84%) were Caucasian. Regional citrate anticoagulation was used in 98.6% of all patients. The most common clinically significant electrolyte derangements were ionized hypocalcemia (22%), ionized hypercalcemia (23%), and hyperphosphatemia (44%). Almost all (97%) patients had at least one additional AE including new onset hypotension (within the first hour after CRRT initiation) (43%), hypothermia (44%), new onset arrhythmias (29%), new onset anemia (31%) and thrombocytopenia (40%).
  
  
  CONCLUSIONS
  ICU patients who require CRRT have a high incidence of AEs. Although the extent to which these complications are attributable to CRRT is not known, clinicians need to be cautious and aware of their high prevalence in this patient population.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minn., USA.
authors.forename: Abbasali
authors.initials: A
authors.lastname: Akhoundi
authors.forename: Balwinder
authors.initials: B
authors.lastname: Singh
authors.forename: Myriam
authors.initials: M
authors.lastname: Vela
authors.forename: Sanjay
authors.initials: S
authors.lastname: Chaudhary
authors.forename: Myles
authors.initials: M
authors.lastname: Monaghan
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Wilson
authors.forename: John J
authors.initials: JJ
authors.lastname: Dillon
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Cartin-Ceba
authors.forename: John C
authors.initials: JC
authors.lastname: Lieske
authors.forename: Ognjen
authors.initials: O
authors.lastname: Gajic
authors.forename: Kianoush
authors.initials: K
authors.lastname: Kashani
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D017582:Renal Replacement Therapy / Q000009:adverse effects* / Q000379:methods; D012189:Retrospective Studies; D012720:Severity of Illness Index