title: [10-year results of using segmental pelvic irradiation combined with local irradiation of the prostate in patients with prostate cancer with multiple bone metastases].
abstract: The objective was to show the importance of external beam radiotherapy (EBRT) to increase the effectiveness of treatment and improve the quality of life of patients with generalized prostate cancer (PC). From 1992 to 2005 at our institution 205 patients with morphologically verified generalized (stages T1-4N0-1M1b) PC received EBRT. EBRT was conducted against the background of hormone therapy. Irradiation was begun with segmental pelvic irradiation with consistent reduction in the volume of exposure to locoregional and local irradiation of the prostate. The total tumor dose on the prostate was adjusted up to therapeutic level (66-72 Gy). In case of PC generalization with a primary lesion of the pelvis and lumbosacral spine, palliative EBRT according to the proposed method was justified. EBRT not only improved the quality of life of patients but also increased its duration.
authors.forename: V V
authors.initials: VV
authors.lastname: Metelev
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010384:Pelvic Bones; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000532:radiotherapy*; D011788:Quality of Life; D012447:Sacrum; D013125:Spinal Neoplasms / Q000532:radiotherapy / Q000556:secondary; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen