title: Alkyl-aryl ketone synthesis via nickel-catalyzed reductive coupling of alkyl halides with aryl acids and anhydrides.
abstract: The present work disclosed a considerably improved method for the construction of alkyl-aryl ketones by the direct coupling of unactivated alkyl bromides with 1.5 equiv. of acids. In addition, the synthesis of aroyl C-glycosides was first achieved by the reductive coupling of 1-glycosyl bromides with acid derivatives, which may otherwise require multi-step synthesis.
authors.affiliation: Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China. hegui_gong@shu.edu.cn qianqun@shu.edu.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jia
authors.forename: Xinghua
authors.initials: X
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Qian
authors.forename: Hegui
authors.initials: H
authors.lastname: Gong