title: MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic.
abstract: Alteration of multidrug resistance-associated protein-1 (MRP1) expression has been associated with certain lung diseases, and this protein may be pivotal in protecting the lungs against endogenous or exogenous toxic compounds. The aim of this study was to evaluate and compare the expression of MRP1 in bronchoalveolar cells from subjects with and without lung cancer who had been chronically exposed to arsenic through drinking water. MRP1 expression was assessed in bronchoalveolar cells in a total of 102 participants. MRP1 expression was significantly decreased in those with arsenic urinary levels >50 μg/L when compared with the controls. In conclusion, chronic arsenic exposure negatively correlates with the expression of MRP1 in BAL cells in patients with lung cancer.
authors.affiliation: Department of Environmental Health, Biomedical Research Center, School of Medicine at Torreón, University of Coahuila, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Recio-Vega
authors.affiliation: Department of Environmental Health, Biomedical Research Center, School of Medicine at Torreón, University of Coahuila, Mexico.
authors.forename: Jose Angel
authors.initials: JA
authors.lastname: Dena-Cazares
authors.affiliation: Department of Environmental Health, Biomedical Research Center, School of Medicine at Torreón, University of Coahuila, Mexico.
authors.forename: Jorge Luis
authors.initials: JL
authors.lastname: Ramirez-de la Peña
authors.affiliation: Department of Pneumology, Instituto Mexicano Del Seguro Social, Torreón, Coahuila, México.
authors.forename: Antonio
authors.initials: A
authors.lastname: Jacobo-Ávila
authors.affiliation: Department of Pneumology, Instituto Mexicano Del Seguro Social, Torreón, Coahuila, México.
authors.forename: Arnulfo
authors.initials: A
authors.lastname: Portales-Castanedo
authors.affiliation: Division of Molecular Medicine, Molecular Genetics Laboratory, Centro De Investigación Biomédica De Occidente, Guadalajara, Jalisco, Mexico.
authors.forename: Martha Patricia
authors.initials: MP
authors.lastname: Gallegos-Arreola
authors.affiliation: Department of Environmental Health, Biomedical Research Center, School of Medicine at Torreón, University of Coahuila, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Ocampo-Gomez
authors.affiliation: Department of Environmental Health, Biomedical Research Center, School of Medicine at Torreón, University of Coahuila, Mexico.
authors.forename: Gladis
authors.initials: G
authors.lastname: Michel-Ramirez
mesh_terms: D000328:Adult; D000368:Aged; D001151:Arsenic / Q000633:toxicity* / Q000652:urine; D001992:Bronchoalveolar Lavage Fluid; D016022:Case-Control Studies; D060766:Drinking Water; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*
chemical_list: D001151:Arsenic; D060766:Drinking Water; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C421109:multidrug resistance-associated protein 1
keywords: ABCC; BAL; MRP1; arsenic; lung cancer