title: Relationship between Foxp3-3279 (rs376158) polymorphism and dust mite allergic conjunctivitis.
abstract: OBJECTIVE
  To investigate the genotyping of Foxp3-3279 (A/Crs376158) genes in patients with dust mite-induced allergic conjunctivitis from Guangdong province and to explore the association between these genes and the susceptibility to dust mite allergic conjunctivitis.
  
  
  METHODS
  In total, 80 patients with dust mite allergic conjunctivitis and 103 healthy Han Chinese were enrolled in the study and received genotyping of Foxp3-3279 (A/C,rs376158) by PCR-SSP technique.
  
  
  RESULTS
  Genotype frequency of Foxp3-3279 AA, CA, and CC in patients with dust mite allergic conjunctivitis were 1.25%, 25.00% and 73.75%,respectively. Gene frequency of C and A in patients with dust mite allergic conjunctivitis were 86.25% and 13.75% with no significant difference from healthy counterparts (both P > 0.05).
  
  
  CONCLUSIONS
  Foxp3-3279 polymorphisms did not significantly differ between patients with dust mite allergic conjunctivitis and healthy controls, implying that this genetic locus is probably not an independent risk factor of the underlying pathogenesis of dust mite allergic conjunctivitis.
authors.forename: Ruiming
authors.initials: R
authors.lastname: Yang
authors.forename: He
authors.initials: H
authors.lastname: Lai
authors.forename: Xiangyin
authors.initials: X
authors.lastname: Sha
authors.forename: Shengqiang
authors.initials: S
authors.lastname: Chen
authors.forename: Yingqian
authors.initials: Y
authors.lastname: Tan
authors.forename: Weifang
authors.initials: W
authors.lastname: Chen
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D003233:Conjunctivitis, Allergic / Q000235:genetics*; D004391:Dust; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D039981:Pyroglyphidae
chemical_list: D004391:Dust; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors