title: Anticancer Effects of Sandalwood (Santalum album).
abstract: Effective management of tumorigenesis requires development of better anticancer agents with greater efficacy and fewer side-effects. Natural products are important sources for the development of chemotherapeutic agents and almost 60% of anticancer drugs are of natural origin. α-Santlol, a sesquiterpene isolated from Sandalwood, is known for a variety of therapeutic properties including anti-inflammatory, anti-oxidant, anti-viral and anti-bacterial activities. Cell line and animal studies reported chemopreventive effects of sandalwood oil and α-santalol without causing toxic side-effects. Our laboratory identified its anticancer effects in chemically-induced skin carcinogenesis in CD-1 and SENCAR mice, ultraviolet-B-induced skin carcinogenesis in SKH-1 mice and in vitro models of melanoma, non-melanoma, breast and prostate cancer. Its ability to induce cell-cycle arrest and apoptosis in cancer cells is its most reported anticancer mechanism of action. The present review discusses studies that support the anticancer effect and the mode of action of sandalwood oil and α-santalol in carcinogenesis.
authors.affiliation: Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, U.S.A.
authors.forename: Sreevidya
authors.initials: S
authors.lastname: Santha
authors.affiliation: Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD, U.S.A. chandradhar.dwivedi@sdstate.edu.
authors.forename: Chandradhar
authors.initials: C
authors.lastname: Dwivedi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D063646:Carcinogenesis / Q000187:drug effects*; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D010938:Plant Oils / Q000627:therapeutic use*; D032123:Santalum / Q000737:chemistry*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D010936:Plant Extracts; D010938:Plant Oils
keywords: Sandalwood; angiogenesis; apoptosis; cancer; carcinogenesis; cell cycle; review; santalol