title: Obstructive Sleep Apnea Using Watch-PAT 200 Is Independently Associated With an Increase in Morning Blood Pressure Surge in Never-Treated Hypertensive Patients.
abstract: This study aimed to examine the association between obstructive sleep apnea (OSA) and morning blood pressure surge in never-treated patients with essential hypertension. This prospective study included a total of 58 patients (mean age, 51.7 years; 55.2% men) with never-treated essential hypertension. The patients were divided into non-OSA (n=23, 49.3±12.7 years) and OSA (n=35, 53.2±9.8 years) groups. The OSA group was defined as having an apnea-hypopnea index level >5 as measured by the Watch-PAT 200. The authors collected 24-hour ambulatory BP, plasma aldosterone concentration, and plasma renin activity data from all of the patients. The measured sleep-trough morning systolic blood pressure (SBP) increases were higher in the OSA group than in the non-OSA group (28.7±11.8 mm Hg vs 19.6±12.8 mm Hg, P=.008). The sleep-trough morning SBP increase was inversely correlated with the lowest oxygen saturation (r=-0.272, P=.039). OSA known to be associated with increased daytime and nocturnal sympathetic activity was associated with significantly higher sleep-trough morning SBP levels in this study.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Jung Sun
authors.initials: JS
authors.lastname: Cho
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Ihm
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Chan Joon
authors.initials: CJ
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Mahn-Won
authors.initials: MW
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Her
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Gyung-Min
authors.initials: GM
authors.lastname: Park
authors.affiliation: Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: Tae-Seok
authors.initials: TS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000295:instrumentation / Q000379:methods; D018660:Blood Pressure Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods; D015992:Body Mass Index; D002940:Circadian Rhythm / Q000502:physiology; D003430:Cross-Sectional Studies; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D011446:Prospective Studies; D012083:Renin / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000503:physiopathology*
chemical_list: D000450:Aldosterone; D012083:Renin