title: Electrical Rhythms Revealed by Harmonic Analysis of a High-Resolution Cardiogram.
abstract: The front-end low-noise electronic amplifiers and high-throughput computing systems made it possible to record ECG with a high resolution in the low-frequency range including the respiration and Mayer frequencies and to analyze ECG with digital filtering technique and harmonic analysis. These tools yielded ECG spectra of narcotized rats, which contained the characteristic pulsatile triplets and pentaplets with splitting constant equal to respiration rate, as well as the peaks at respiration and Mayer frequencies. The harmonic analysis of ECG determined the frequency parameters employed to tune the software bandpass filters, which revealed the respiratory (R) and Mayer (M) waves in the time domain with the amplitudes of 20-30 μV amounting to 5% ECG amplitude. The depolarizing myorelaxant succinylcholine chloride capable to trigger various types of arrhythmias, transiently increased R-wave, inhibited M-wave, and provoked a negative U-wave within a heartbeat ECG cycle synchronously with inspiration. It is hypothesized that M-, R-, and U-waves in ECG reflect cardiotropic activity of autonomic nervous system. The respective spectral peaks in ECG can be employed to assess intensity of sympathetic and parasympathetic cardiotropic influences, their balance, and the risk of arrhythmias.
authors.affiliation: Department of Physiology, Russian Cardiology Research-and-Development Center, Ministry of Health of the Russian Federation, Moscow, Russia, s_revenko@mail.ru.
authors.forename: S V
authors.initials: SV
authors.lastname: Revenko
authors.forename: L Ya
authors.initials: LY
authors.lastname: Selector
authors.forename: I Yu
authors.initials: IY
authors.lastname: Gavrilov
authors.forename: A V
authors.initials: AV
authors.lastname: Nesterov
authors.forename: E V
authors.initials: EV
authors.lastname: Limonov
authors.forename: I S
authors.initials: IS
authors.lastname: Mudraya
authors.forename: V I
authors.initials: VI
authors.lastname: Kirpatovskii
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods*; D005583:Fourier Analysis; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D051381:Rats; D012119:Respiration; D012815:Signal Processing, Computer-Assisted; D013390:Succinylcholine / Q000494:pharmacology
chemical_list: D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine