title: Synthesis of [(2)H6]ceftazidime as a stable isotopically labeled internal standard.
abstract: Ceftazidime is a third generation cephalosporin antibiotic that has activity against a wide range of Gram-negative and Gram-positive bacterial pathogens, including Escherichia coli and Pseudomonas aeruginosa. Stable isotope-labeled ceftazidime was required for use as an internal standard in LC-MS/MS assays, and a route was developed to make [(2)H6]ceftazidime in eight steps from the commercially available labeled starting material [(2)H7]isobutyric acid.
authors.affiliation: Pharmaron Beijing, Co. Ltd., 6 Taihe Road, BDA, Beijing, 100176, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Bian
authors.affiliation: AstraZeneca UK Ltd., Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
authors.forename: Nick
authors.identifier: http://orcid.org/0000-0002-9025-7015
authors.initials: N
authors.lastname: Bushby
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002442:Ceftazidime / Q000737:chemistry*; D003903:Deuterium / Q000737:chemistry*; D007553:Isotope Labeling
chemical_list: D000890:Anti-Infective Agents; D002442:Ceftazidime; D003903:Deuterium
keywords: ceftazidime; cephalosporin; stable isotope