title: Predictive value of MRI parameters in severity and recovery of first-episode myelitis in aquaporin-4 antibody disease.
abstract: BACKGROUND
  Neuromyelitis optica spectrum disorder (NMOSD) associated with aquaporin-4 antibodies (AQP4-Ab) typically causes longitudinally-extensive transverse myelitis (LETM). Few data exist about the association of MRI features with LETM attack severity and recovery.
  
  
  METHODS
  AQP4-Ab positive NMOSD patients with a first myelitis attack were retrospectively identified and spinal MRI scans reviewed. Association of MRI features with EDSS scores at attack nadir and recovery was evaluated.
  
  
  RESULTS
  22 patients were included. Median nadir EDSS score was 8 (range 1 to 8.5). Nadir EDSS scores correlated with total MRI lesion length (r=0.48, p=0.025), higher scores were seen in those with gadolinium enhancement (p=0.025) and there was a trend towards higher scores with central cord involvement. The median recovery EDSS was 6 (range 0 to 10). Total lesion length correlated with poor recovery (r=0.48, p=0.027) but this was confounded by correlation between nadir and recovery EDSS scores.
  
  
  CONCLUSIONS
  We confirm that myelitis in AQP4-Ab disease is severe and show that the severity correlates with lesion length and residual disability. Spinal cord lesions in first myelitis attacks are similar to appearances reported later in the disease course, with propensity to involve the central grey matter and high frequency of cord oedema and T1 hypointensity.
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, UK. Electronic address: agmurchison@gmail.com.
authors.forename: Andrew
authors.initials: A
authors.lastname: Murchison
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, UK. Electronic address: jokitley@doctors.org.uk.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kitley
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, UK. Electronic address: maria.leite@imm.ox.ac.uk.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Leite
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, UK. Electronic address: Wilhelm.kueker@ouh.nhs.uk.
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Küker
authors.affiliation: Nuffield Department of Clinical Neurosciences, Oxford University Hospitals NHS Trust, University of Oxford, Oxford, UK. Electronic address: jacqueline.palace@ndcn.ox.ac.uk.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Palace
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D051401:Aquaporin 4 / Q000276:immunology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009471:Neuromyelitis Optica / Q000097:blood* / Q000473:pathology* / Q000628:therapy; D010951:Plasma Exchange / Q000379:methods; D011237:Predictive Value of Tests; D020127:Recovery of Function / Q000502:physiology*; D013116:Spinal Cord / Q000473:pathology; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: C496030:AQP4 protein, human; D000906:Antibodies; D051401:Aquaporin 4
keywords: AQP4; Aquaporin-4; Disability; NMO; Neuromyelitis optica