title: The effect of sevoflurane versus propofol anesthesia on troponin I after congenital heart surgery, a randomized clinical trial.
abstract: BACKGROUND
  The ischemic preconditioning phenomenon can save myocardium against move severe ischemic damages and reduce infarction size and furthermore a heart rhythm disturbance. In this study we examine relationship between troponin I (as a structural myocardial protein) level and anesthetic agents in the children.
  
  
  METHODS
  In this study 84 children under 12 years age before cardiac surgery were divided randomly into two groups of 42 each. For anesthetic maintenance sevoflurane with dose of 0.5-1 MAC was used in Group 1 and 100-150 mg/kg/min of intravenous propofol in Group 2 for maintenance of anesthesia. Troponin I level was assessed 2 before and 1 hour after anesthetic induction. Outcome measures included the serum cardiac troponin I level in children before and after surgery in two study groups.
  
  
  RESULTS
  There was no significant difference between two groups in indices and both groups were homogenous in this point of view. The troponin I level after surgery was significantly increased in two groups. In the sevoflurane group it was 0.04 ± 0.12 to 0.05 ± 0.09 ng/ml (P value = 0.003) and the propofol group was 0.12 ± 0.26 to 0.19 ± 0.38 ng/ml (P value = 0.001).
  
  
  CONCLUSIONS
  In this study two Anesthetic regimens were compared to assess the mean troponin I level before and after pediatric closed heart surgery, and it was shown that mean troponin level before and after surgery in the sevoflurane group was less than the propofol group. But this result was not statistically significant. These results indicate that although more protective effects of sevoflurane on myocardial injuries during pediatric cardiac surgery is predominant but this effect has no significant difference in the propofol group.
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Mahdavi
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Abdollahi
authors.affiliation: Department of Anesthesiology, Faculty Member of Shahid Sadoughi Medical University of Yazd (Anesthesia and Operation Room Group), Yazd, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Entezari
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Salehi
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Habibollah
authors.initials: H
authors.lastname: Hosseini
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Syed Hossein
authors.initials: SH
authors.lastname: Moshtaghioon
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Rafie
authors.affiliation: Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Rahimianfar
keywords: Heart surgery; Troponin I; pediatric; propofol; sevoflurane