title: Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor.
abstract: Silicosis is a fibrotic lung disease caused by the inhalation of silica particles, and is considered an occupational disease, given that these particles are present in the working environment of many mining and civil construction industries. NLRP3 inflammasome activation is an important mechanism during the inflammatory process of silicosis, and it promotes the production of cytokines, such as IL-1β and IL-18. ATP also plays an important role in silicosis. Specifically, extracellular ATP can activate P2X7 receptor, which then participates in the complete assembly of the NLRP3 inflammasome and its activation. Herein, we analyze the literature to provide a better understanding of the mechanisms underlying inflammasome activation and the role of P2X7 receptors in macrophages during silicosis.
authors.affiliation: Laboratório de Imunofisiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Departamento de Ciências da Natureza, Instituto de Aplicação Fernando Rodrigues da Silveira,Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Luna-Gomes
authors.affiliation: Laboratório de Imunofisiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Patricia Teixeira
authors.initials: PT
authors.lastname: Santana
authors.affiliation: Laboratório de Imunofisiologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: rcsilva@biof.ufrj.br.
authors.forename: Robson
authors.initials: R
authors.lastname: Coutinho-Silva
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002352:Carrier Proteins / Q000276:immunology* / Q000378:metabolism; D004789:Enzyme Activation / Q000276:immunology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology; D055370:Lung Injury / Q000276:immunology / Q000473:pathology; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D058486:Receptors, Purinergic P2X7 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D012822:Silicon Dioxide / Q000276:immunology*; D012829:Silicosis / Q000276:immunology* / Q000473:pathology
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D058486:Receptors, Purinergic P2X7; D012822:Silicon Dioxide; D000255:Adenosine Triphosphate
keywords: ATP; Inflammasome; Interleukin 1β; NLRP3; P2X7 receptor; Silica