title: Anti-diabetic potential of selected ethno-medicinal plants of north east India.
abstract: BACKGROUND
  Through one-to-one interaction with the traditional healers, the present study has identified 15 medicinal plant species traditionally used as remedies to control diabetes.
  
  
  METHODS
  The methanolic extracts were screened for their α-glucosidase inhibitory activity. Hypoglycemic activity was assessed following glucose, sucrose and starch tolerance test on normal and STZ induced diabetic rats.
  
  
  RESULTS
  Ficus cunia extract had the highest α-glucosidase inhibitory potency with IC50 1.39±0.74 µg mL(-1) followed by Schima wallichi (IC50 1.43±0.20 µg mL(-1)) and Wendlandia glabrata (IC50 1.67±0.33 µg mL(-1)). In STZ induced diabetic rat model, F. cunia and W glabrata extracts reduced blood glucose concentration to near normal up to 14 days when administered 48 h after STZ.
  
  
  CONCLUSIONS
  The present study supports the traditional use of some of these medicinal plants in anti-diabetic remedies. The present study contributes to evidence for use of traditional medicine.
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Yunus
authors.initials: Y
authors.lastname: Sheikh
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Beebina Chanu
authors.initials: BC
authors.lastname: Maibam
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Dipak
authors.initials: D
authors.lastname: Biswas
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Surbala
authors.initials: S
authors.lastname: Laisharm
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Deb
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Narayan Chandra
authors.initials: NC
authors.lastname: Talukdar
authors.affiliation: Laboratory of Natural Medicinal Chemistry, Natural Product Chemistry & Pharmacology Programme, Institute of Bioresources & Sustainable Development, Takyelpat, Imphal 795001, Manipur, India. Electronic address: jcborah03@yahoo.com.
authors.forename: Jagat Chandra
authors.initials: JC
authors.lastname: Borah
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005951:Glucose Tolerance Test; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D007194:India; D007928:Lethal Dose 50; D019684:Magnoliopsida; D008297:Male; D008519:Medicine, Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D010946:Plants, Medicinal; D017208:Rats, Wistar; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000520:alpha-Glucosidases
keywords: Diabetes; Ficus cunia; Wendlandia glabrata and Hypoglycemic; α-glucosidase