title: BioMiner: Paving the Way for Personalized Medicine.
abstract: Personalized medicine is promising a revolution for medicine and human biology in the 21st century. The scientific foundation for this revolution is accomplished by analyzing biological high-throughput data sets from genomics, transcriptomics, proteomics, and metabolomics. Currently, access to these data has been limited to either rather simple Web-based tools, which do not grant much insight or analysis by trained specialists, without firsthand involvement of the physician. Here, we present the novel Web-based tool "BioMiner," which was developed within the scope of an international and interdisciplinary project (SYSTHER) and gives access to a variety of high-throughput data sets. It provides the user with convenient tools to analyze complex cross-omics data sets and grants enhanced visualization abilities. BioMiner incorporates transcriptomic and cross-omics high-throughput data sets, with a focus on cancer. A public instance of BioMiner along with the database is available at http://systherDB.microdiscovery.de/, login and password: "systher"; a tutorial detailing the usage of BioMiner can be found in the Supplementary File.
authors.affiliation: Research and Development, MicroDiscovery GmbH, Berlin, Germany.
authors.forename: Chris
authors.initials: C
authors.lastname: Bauer
authors.affiliation: Research and Development, MicroDiscovery GmbH, Berlin, Germany.
authors.forename: Karol
authors.initials: K
authors.lastname: Stec
authors.affiliation: Research and Development, MicroDiscovery GmbH, Berlin, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Glintschert
authors.affiliation: Department for Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Gruden
authors.affiliation: Department of Neurosurgery, Klinikum der Ludwig-Maximilian-Universität München, Munich, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schichor
authors.affiliation: Systems Immunology Lab, Department of Biology, Humboldt University, Berlin, Germany. ; Research Center ImmunoSciences, Charité University of Medicine Berlin, Berlin, Germany.
authors.forename: Michal
authors.initials: M
authors.lastname: Or-Guil
authors.affiliation: Institute of Biochemistry and Biology, University of Potsdam, Potsdam, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Selbig
authors.affiliation: Research and Development, MicroDiscovery GmbH, Berlin, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schuchhardt
keywords: biomarker detection; cancer; data mining; multiomics data integration; pathway visualization; personalized medicine