title: Malignant systemic hypertension, encephalopathy and bradycardia following splenectomy for hereditary spherocytosis.
abstract: An 8-year-old girl suffering from hereditary spherocytosis underwent splenectomy for chronic severe anaemia. Surgery was uneventful and the patient had a good early postoperative recovery. On the third postoperative day, however, she developed severe headache with associated abnormal movements of upper limbs and nystagmus. She had a heart rate of 50 bpm and a blood pressure of 180/110 mm Hg. She was managed with triple antihypertensives, antiepileptics and sedatives. She recovered slowly over 2 weeks and is fine at 5 months follow-up.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Abhimanyu
authors.initials: A
authors.lastname: Varshney
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Dey
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Gupta
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000008:administration & dosage; D001919:Bradycardia / Q000188:drug therapy / Q000209:etiology*; D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology; D002648:Child; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy / Q000209:etiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D009759:Nystagmus, Pathologic / Q000188:drug therapy / Q000209:etiology*; D013103:Spherocytosis, Hereditary / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000959:Antihypertensive Agents; D006993:Hypnotics and Sedatives