title: Celiac disease, non-celiac gluten sensitivity and inflammatory bowel disease.
abstract: Celiac disease (CD) and inflammatory bowel disease (IBD), such as Crohn's disease (CrD) and ulcerative colitis (UC), are chronic inflammatory condition of the gastro-intestinal tract. The prevalence of IBD in celiac patients has been reported as 5-10 times higher than in the general population. The possibility of the presence of CD in IBD should be considered in IBD patients with long-term iron deficiency anemia (IDA) not responsive to iron supplementation. Non-celiac gluten sensitivity (NCGS) is characterized by intestinal and extra intestinal symptoms due to the ingestion of gluten-containing food in subject without CD and/or wheat allergy. Patients with Crohn's disease and SR-NCGS were more significantly affected by joint pains compared to UC patients (50% versus 11.1%). In Crohn's patients, a higher percentage of fatigue (50% versus 38.9%) and headache (27.3% versus 22.2%) was evident. For the association between NCGS and IBD new studies are warranted and, at this moment, a gluten free diet (GFD) may be useful more in CrD than in UC.
authors.affiliation: Gastroenterology and Hepatology Unit, Medical Department, Desio Hospital, Desio, Monza e Brianza, Italy - caselgio@tiscali.it.
authors.forename: G
authors.initials: G
authors.lastname: Casella
authors.forename: C
authors.initials: C
authors.lastname: Di Bella
authors.forename: M
authors.initials: M
authors.lastname: Salemme
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: E
authors.initials: E
authors.lastname: Antonelli
authors.forename: V
authors.initials: V
authors.lastname: Baldini
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D005983:Glutens / Q000009:adverse effects*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D015995:Prevalence
chemical_list: D005983:Glutens