title: Synergy between cannabidiol, cannabidiolic acid, and Δ⁹-tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew).
abstract: Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD, and its acidic precursor, cannabidiolic acid (CBDA), have all been shown to have antiemetic properties in the Suncus murinus (S. murinus; house musk shrew). Here we show that when subthreshold antiemetic doses of CBD (2.5 mg/kg ip) or CBDA (0.05 mg/kg ip) are combined with a subthreshold antiemetic dose of THC (1 mg/kg ip) in the S. murinus, both lithium-chloride-induced vomiting and abdominal retching are dramatically suppressed. These results suggest that combined effects of these compounds may lead to better control of vomiting with fewer side effects.
authors.affiliation: Department of Psychology, University of Guelph.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Rock
authors.affiliation: Department of Psychology, University of Guelph.
authors.forename: Linda A
authors.initials: LA
authors.lastname: Parker
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D002185:Cannabidiol / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D004195:Disease Models, Animal; D013759:Dronabinol / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D018021:Lithium Chloride; D008297:Male; D012788:Shrews; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D002186:Cannabinoids; D002185:Cannabidiol; D013759:Dronabinol; C006884:cannabidiolic acid; D018021:Lithium Chloride