title: [Acid-base status in patients treated with peritoneal dialysis].
abstract: When compared to hemodialysis, peritoneal dialysis is very simple yet low cost method of renal replacement therapy. Series of studies have shown its superiority in preserving residual renal function, postponing uremic complications, maintaining the acid-base balance and achieving better post-transplant outcome in patients treated with this method. Despite obvious advantages, its role in the treatment of chronic kidney disease is still not as important as it should be. Metabolic acidosis is an inevitable complication associated with progressive loss of kidney function. Its impact on mineral and muscle metabolism, residual renal function, allograft function and anemia is very complex but can be successfully managed. The aim of our study was to evaluate the efficiency in preserving the acid-base balance in patients undergoing peritoneal dialysis at Zagreb University Hospital Center. Twenty-eight patients were enrolled in the study. The mean time spent on the treatment was 32.39 ± 43.43 months. Only lactate-buffered peritoneal dialysis fluids were used in the treatment. Acid-base balance was completely maintained in 73.07% of patients; 11.54% of patients were found in the state of mild metabolic acidosis, and the same percentage of patients were in the state of mild metabolic alkalosis. In one patient, mixed alkalosis with respiratory and metabolic component was present. The results of this study showed that acid-base balance could be maintained successfully in patients undergoing peritoneal dialysis, even only with lactate-buffered solutions included in the treatment, although they were continuously proclaimed as inferior in comparison with bicarbonate-buffered ones. In well educated and informed patients who carefully use this method, accompanied by the attentive and thorough care of their physicians, this method can provide quality continuous replacement of lost renal function as well as better quality of life.
authors.forename: Lea
authors.initials: L
authors.lastname: Katalinić
authors.forename: Kristina
authors.initials: K
authors.lastname: Blaslov
authors.forename: Eva
authors.initials: E
authors.lastname: Pasini
authors.forename: Petar
authors.initials: P
authors.lastname: Kes
authors.forename: Nikolina
authors.initials: N
authors.lastname: Bašić-Jukić
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000139:chemically induced / Q000150:complications / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000008:administration & dosage / Q000009:adverse effects; D002021:Buffers; D005260:Female; D015312:Hemodialysis Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007773:Lactates / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000379:methods*; D011788:Quality of Life; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy*
chemical_list: D001639:Bicarbonates; D002021:Buffers; D015312:Hemodialysis Solutions; D007773:Lactates