title: Small-nucleic-acid-based therapeutic strategy targeting the transcription factors regulating the vascular inflammation, remodeling and fibrosis in atherosclerosis.
abstract: Atherosclerosis arises when injury to the arterial wall induces an inflammatory cascade that is sustained by a complex network of cytokines, together with accumulation of lipids and fibrous material. Inflammatory cascades involve leukocyte adherence and chemotaxis, which are coordinated by the local secretion of adhesion molecules, chemotactic factors, and cytokines. Transcription factors are critical to the integration of the various steps of the cascade response to mediators of vascular injury, and are induced in a stimulus-dependent and cell-type-specific manner. Several small-nucleic-acid-based therapeutic strategies have recently been developed to target transcription factors: antisense oligodeoxynucleotides, RNA interference, microRNA, and decoy oligodeoxynucleotides. The aim of this review was to provide an overview of these particular targeted therapeutic strategies, toward regulation of the vascular inflammation, remodeling and fibrosis associated with atherosclerosis.
authors.affiliation: Department of Radiology, Catholic University of Daegu Medical Center, School of Medicine, Catholic University of Daegu, Daegu 705-718, Korea. ysw.badest.2010@gmail.com.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Youn
authors.affiliation: Department of Pathology, Catholic University of Daegu Medical Center, School of Medicine, Catholic University of Daegu, Daegu 705-718, Korea. kkpark@cu.ac.kr.
authors.forename: Kwan-Kyu
authors.initials: KK
authors.lastname: Park
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000150:complications / Q000235:genetics / Q000628:therapy*; D005355:Fibrosis; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000628:therapy*; D035683:MicroRNAs / Q000235:genetics / Q000627:therapeutic use*; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D034741:RNA, Small Interfering / Q000235:genetics / Q000627:therapeutic use*; D014157:Transcription Factors / Q000235:genetics*; D014652:Vascular Diseases / Q000150:complications / Q000235:genetics / Q000628:therapy
chemical_list: D035683:MicroRNAs; D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering; D014157:Transcription Factors
keywords: atherosclerosis; fibrosis; gene therapy; inflammation; oligodeoxynucleotides; remodeling; transcription factor