title: Evolution of V genes from the TRV loci of mammals.
abstract: Information concerning the evolution of T lymphocyte receptors (TCR) can be deciphered from that part of the molecule that recognizes antigen presented by major histocompatibility complex (MHC), namely the variable (V) regions. The genes that code for these variable regions are found within the TCR loci. Here, we describe a study of the evolutionary origin of V genes that code for the α and β chains of the TCR loci of mammals. In particular, we demonstrate that most of the 35 TRAV and 25 TRBV conserved genes found in Primates are also found in other Eutheria, while in Marsupials, Monotremes, and Reptiles, these genes diversified in a different manner. We also show that in mammals, all TRAV genes are derived from five ancestral genes, while all TRBV genes originate from four such genes. In Reptiles, the five TRAV and three out of the four TRBV ancestral genes exist, as well as other V genes not found in mammals. We also studied the TRGV and TRDV loci from all mammals, and we show a relationship of the TRDV to the TRAV locus throughout evolutionary time.
authors.affiliation: Department of Informatics, University of Vigo, 32004, Ourense, Spain, olivieri@ei.uvigo.es.
authors.forename: David N
authors.initials: DN
authors.lastname: Olivieri
authors.forename: Santiago
authors.initials: S
authors.lastname: Gambón-Cerdá
authors.forename: Francisco
authors.initials: F
authors.lastname: Gambón-Deza
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D015723:Gene Library; D007135:Immunoglobulin Variable Region / Q000235:genetics* / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D008322:Mammals / Q000235:genetics / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology*; D012104:Reptiles / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment
chemical_list: D007135:Immunoglobulin Variable Region; D016693:Receptors, Antigen, T-Cell, alpha-beta