title: Ketogenic diet exhibits anti-inflammatory properties.
abstract: The ketogenic diet (KD) is an established treatment for refractory epilepsy, including some inflammation-induced epileptic encephalopathies. In a lipopolysaccharide (LPS)-induced fever model in rats, we found that animals given the KD for 14 days showed less fever and lower proinflammatory cytokine levels than control animals. However, KD rats exhibited a decrease in circulating levels of arachidonic acid and long-chain n-3 polyunsaturated fatty acids (PUFAs), suggesting that the anti-inflammatory effect of KD was probably not due to an increase in anti-inflammatory n-3 PUFA derivatives. These properties might be of interest in some conditions such as fever-induced refractory epileptic encephalopathy in school-aged children.
authors.affiliation: INSERM, U1141, Paris, France.|INSERM UMR1141, Paris Diderot University, Paris, France.
authors.forename: Nina
authors.initials: N
authors.lastname: Dupuis
authors.affiliation: INSERM, U1141, Paris, France.
authors.forename: Niccolo
authors.initials: N
authors.lastname: Curatolo
authors.affiliation: INSERM, U1141, Paris, France.|AP-HP, Biochemistery Department, Robert Debre Univeristy Hospital, Paris, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Benoist
authors.affiliation: INSERM, U1141, Paris, France.|INSERM UMR1141, Paris Diderot University, Paris, France.|AP-HP, Pediatric Neurology Department, Robert Debre University Hospital, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Auvin
mesh_terms: D000818:Animals; D055423:Diet, Ketogenic / Q000379:methods*; D005334:Fever / Q000097:blood* / Q000178:diet therapy*; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018836:Inflammation Mediators
keywords: Epilepsy; FIRES; IL-1β; Ketogenic diet; Polyunsaturated fatty acids