title: Genome-wide association study identifies QTLs for EBV of backfat thickness and average daily gain in Duroc pigs.
abstract: Backfat thickness (BFT) and average daily gain (ADG) are two important economic traits in commercial swine production. Identifying QTLs and uncovering the molecular mechanism for BFT and ADG would greatly help to speed up the breeding progress. In current breeding program, EBV for these two traits are calculated and formulated a comprehensive breeding index, which then be used to improve pig performance. Using Illumina PorcineSNP60 BeadChip, a pilot genomewide association studies (GWAS) for BFT and ADG in 83 Duroc pigs were performed. A total of 31 genome-wise significant SN Ps were detected to be associated with BFT on SSC 4, 9, 11, 12 and 14, ten of which were coincident with previously reported QTL regions. There are two genome-wise loci prominently associated with ADG on SSC2 and SSC13, respectively. The two loci on SSC2 are well overlapped with the QTL regions previously reported. All the 31 significant SNPs associated with BFT are verified on 219 outbreed pigs, six SN Ps reach an extreme significant level and seven SNP reaches a significant level, CACNA1E and ACBD6 are chosen as positional candidate genes. Our findings not only confirmed previously findings, but also revealed a number of novel SNPs associated with BFT and ADG. Two positional candidate genes CACNA1E and ACBD6 were identified for further study. These results would facilitate the identification of causative genes for BFT and ADG.
authors.forename: Y
authors.initials: Y
authors.lastname: Long
authors.forename: G R
authors.initials: GR
authors.lastname: Ruan
authors.forename: Y
authors.initials: Y
authors.lastname: Su
authors.forename: S J
authors.initials: SJ
authors.lastname: Xiao
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: N S
authors.initials: NS
authors.lastname: Ding
authors.forename: L S
authors.initials: LS
authors.lastname: Huang
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D050154:Adiposity / Q000235:genetics*; D000818:Animals; D020908:Calcium Channels, R-Type / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D008297:Male; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable; D013552:Swine / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*
chemical_list: D018528:ATP-Binding Cassette Transporters; D020908:Calcium Channels, R-Type