title: Surgical Management of Barrett's Esophagus.
abstract: Patients with gastroesophageal reflux disease and Barrett's esophagus can be a management challenge for the treating physician or surgeon. The goals of therapy include relief of reflux symptoms, induction of histologic regression, and prevention of progression of intestinal metaplasia to dysplasia or invasive carcinoma. Antireflux surgery is effective at achieving these end points, although ongoing follow-up and endoscopic surveillance are essential. In cases of dysplasia or early esophageal neoplasia associated with Barrett's esophagus, endoscopic resection and ablation have supplanted esophagectomy as the standard of care in most cases. Esophageal resection continues to have a role, however, in a minority of appropriately selected candidates.
authors.affiliation: Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Box Surgery, Rochester, NY 14642, USA.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Peyre
authors.affiliation: Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Box Surgery, Rochester, NY 14642, USA. Electronic address: Thomas_watson@urmc.rochester.edu.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Watson
mesh_terms: D055011:Ablation Techniques; D000230:Adenocarcinoma / Q000601:surgery*; D001471:Barrett Esophagus / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000601:surgery*; D050782:Esophageal pH Monitoring; D016629:Esophagectomy; D004945:Esophagoscopy; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009092:Mucous Membrane / Q000601:surgery; D011182:Postoperative Care; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
keywords: Antireflux surgery; Barrett’s esophagus; Esophagectomy; Intramucosal adenocarcinoma; Nissen fundoplication