title: Antithrombotic Activity of a New Hypoglycemic Compound Limiglidole in Mouse Model of Cell Thrombosis.
abstract: Antithrombotic activity of hypoglycemic compound limiglidole that exhibits antiplatelet activity 2-fold exceeded activity of antiplatelet agent acetylsalicylic acid in the mouse model of systemic collagen-epinephrine thrombosis. Limiglidole signifi cantly reduced the relative and mean area of blood clots in the sections of mouse lungs.
authors.affiliation: Department of Pharmacology, Volgograd State Medical University, Volgograd, Russia, aidakucheryavenko@yandex.ru.
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheryavenko
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
mesh_terms: D000818:Animals; D001160:Arterioles / Q000473:pathology; D001241:Aspirin / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D002196:Capillaries / Q000473:pathology; D003094:Collagen / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D007004:Hypoglycemic Agents; D008168:Lung / Q000098:blood supply / Q000473:pathology; D008297:Male; D051379:Mice; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D057705:Transendothelial and Transepithelial Migration / Q000187:drug effects
chemical_list: D001562:Benzimidazoles; D007004:Hypoglycemic Agents; D010975:Platelet Aggregation Inhibitors; D003094:Collagen; D001241:Aspirin; C000605768:2-(2,3-dihydro-9H-imidazo(1,2-a)benzimidazol-9-yl)-N,N-diethylethanamine; D004837:Epinephrine