title: A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib.
abstract: BACKGROUND
  Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis.
  
  
  METHODS
  The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis.
  
  
  CONCLUSIONS
  The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.
authors.affiliation: Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, dggotti@virgilio.it.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Gotti
authors.forename: Veronica
authors.initials: V
authors.lastname: Biassoni
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Schiavello
authors.forename: Filippo
authors.initials: F
authors.lastname: Spreafico
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Calareso
authors.forename: Emilia
authors.initials: E
authors.lastname: Pecori
authors.forename: Lorenza
authors.initials: L
authors.lastname: Gandola
authors.forename: Maura
authors.initials: M
authors.lastname: Massimino
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000068579:Celecoxib / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018335:Rhabdoid Tumor / Q000188:drug therapy*; D013120:Spinal Cord Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000077235:Vinorelbine; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D014747:Vinblastine; D003520:Cyclophosphamide; D000068579:Celecoxib; D000077235:Vinorelbine