title: Intraoperative radiation therapy (IORT) for gynecologic malignancies.
abstract: Every year almost 95,000 women are diagnosed with a gynecologic malignancy and over 28,000 women will succumb to their disease. For patients with an isolated locoregional recurrence after primary therapy, surgical resection may sometimes provide a chance of cure. To optimize the chance of local control intraoperative radiation therapy (IORT) has been used. The combination of salvage surgery and IORT has resulted in reasonable control in the IORT field. The addition of external beam radiation to limited volumes seems to result in improved disease control over surgery and IORT alone. Side effects are closely related to radical surgery, although neuropathy is seen more frequently after IORT; especially if doses of >20Gy are prescribed. Margin status remains critical, even with IORT.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecology Oncology, Ohio State University Wexner Medical Center, Columbus, OH, United States; James Comprehensive Cancer Center, Columbus, OH, United States. Electronic address: Floor.Backes@osumc.edu.
authors.forename: Floor J
authors.initials: FJ
authors.lastname: Backes
authors.affiliation: James Comprehensive Cancer Center, Columbus, OH, United States; Department of Radiation Oncology, Ohio State University Wexner Medical Center, Columbus, OH, United States.
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Martin
mesh_terms: D005260:Female; D005833:Genital Neoplasms, Female / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods
keywords: Cervical cancer; Endometrial cancer; Intraoperative radiation therapy (IORT); Ovarian cancer; Radiation techniques; Radical salvage surgery