title: Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis.
abstract: Alcohol intake leads to the distribution of alcohol and its metabolite, acetaldehyde throughout the blood and organs. Hepatic cirrhosis is associated with abnormal red blood cell morphology and function, particularly impaired red blood cell deformability. To investigate the effect of drinking on red blood cells in patients with hepatic cirrhosis, erythrocyte deformability was evaluated in response to alcohol and acetaldehyde tolerance. Erythrocyte deformability in 10 healthy and 15 cirrhotic subjects was examined by filterability of the red blood cells. Erythrocyte deformability decreased markedly in the cirrhosis group compared with the healthy group (p < 0.05). No significant change in erythrocyte deformability was observed in healthy or cirrhotic subjects due to ethanol 100 mM tolerance. Acetaldehyde tolerance elicited a significant decrease in erythrocyte deformability at 2 mM in the cirrhosis group (p < 0.05). Alcohol consumption in cirrhotic patients was suggested to worsen erythrocyte deformability and red blood cell function. Decreased erythrocyte deformability worsens microcirculation in the liver, resulting in more severe hepatic dysfunction.
authors.forename: Koichi
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Kota
authors.initials: K
authors.lastname: Tsuruya
authors.forename: Kazuya
authors.initials: K
authors.lastname: Anzai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Arase
authors.forename: Shunji
authors.initials: S
authors.lastname: Hirose
authors.forename: Tatehiro
authors.initials: T
authors.lastname: Kagawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mine
authors.forename: Shohei
authors.initials: S
authors.lastname: Matsuzaki
mesh_terms: D000079:Acetaldehyde / Q000494:pharmacology*; D048430:Cell Shape / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology
chemical_list: D000431:Ethanol; D000079:Acetaldehyde