title: A Multisite, Randomized Controlled Clinical Trial of Computerized Cognitive Remediation Therapy for Schizophrenia.
abstract: The effectiveness of cognitive remediation therapy (CRT) for the neuropsychological deficits seen in schizophrenia is supported by meta-analysis. However, a recent methodologically rigorous trial had negative findings. In this study, 130 chronic schizophrenic patients were randomly assigned to computerized CRT, an active computerized control condition (CC) or treatment as usual (TAU). Primary outcome measures were 2 ecologically valid batteries of executive function and memory, rated under blind conditions; other executive and memory tests and a measure of overall cognitive function were also employed. Carer ratings of executive and memory failures in daily life were obtained before and after treatment. Computerized CRT was found to produce improvement on the training tasks, but this did not transfer to gains on the primary outcome measures and most other neuropsychological tests in comparison to either CC or TAU conditions. Nor did the intervention result in benefits on carer ratings of daily life cognitive failures. According to this study, computerized CRT is not effective in schizophrenia. The use of both active and passive CCs suggests that nature of the control group is not an important factor influencing results.
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain; CIBERSAM, Spain; Litwin-Zucker Research Center, the Feinstein Institute for Medical Research, Manhasset, New York;
authors.forename: Jesús J
authors.initials: JJ
authors.lastname: Gomar
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain;
authors.forename: Elia
authors.initials: E
authors.lastname: Valls
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain; CIBERSAM, Spain; Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK;
authors.forename: Joaquim
authors.initials: J
authors.lastname: Radua
authors.affiliation: Psicoclínica Mare de Déu de la Mercè, Barcelona, Spain;
authors.forename: Celia
authors.initials: C
authors.lastname: Mareca
authors.affiliation: Hospital Sagrat Cor Martorell, Barcelona, Spain;
authors.forename: Josep
authors.initials: J
authors.lastname: Tristany
authors.affiliation: Clinica San Miguel, Madrid, Spain;
authors.forename: Francisco
authors.initials: F
authors.lastname: del Olmo
authors.affiliation: Centros de Rehabilitacion Picosocial de Aranjuez y Vallecas, Madrid, Spain;
authors.forename: Carlos
authors.initials: C
authors.lastname: Rebolleda-Gil
authors.affiliation: Clinica San Miguel, Madrid, Spain;
authors.forename: María
authors.initials: M
authors.lastname: Jañez-Álvarez
authors.affiliation: Complejo Asistencial Benito Menni, Ciempozuelos, Madrid, Spain;
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: de Álvaro
authors.affiliation: Hospital de San Luis, Palencia, Spain;
authors.forename: María R
authors.initials: MR
authors.lastname: Ovejero
authors.affiliation: Benito Menni CASM, Sant Boi de Llobregat, Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Llorente
authors.affiliation: Psicoclínica Mare de Déu de la Mercè, Barcelona, Spain;
authors.forename: Cristina
authors.initials: C
authors.lastname: Teixidó
authors.affiliation: Hospital Sagrat Cor Martorell, Barcelona, Spain;
authors.forename: Ana M
authors.initials: AM
authors.lastname: Donaire
authors.affiliation: Clinica San Miguel, Madrid, Spain;
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Laredo
authors.affiliation: Centros de Rehabilitacion Picosocial de Aranjuez y Vallecas, Madrid, Spain;
authors.forename: Andrea
authors.initials: A
authors.lastname: Lazcanoiturburu
authors.affiliation: Complejo Asistencial Benito Menni, Ciempozuelos, Madrid, Spain;
authors.forename: Luis
authors.initials: L
authors.lastname: Granell
authors.affiliation: Hospital de San Luis, Palencia, Spain;
authors.forename: Cristina de Pablo
authors.initials: Cde P
authors.lastname: Mozo
authors.affiliation: Benito Menni CASM, Sant Boi de Llobregat, Barcelona, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Pérez-Hernández
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain; CIBERSAM, Spain;
authors.forename: Ana
authors.initials: A
authors.lastname: Moreno-Alcázar
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain; CIBERSAM, Spain; edith.pomarol@gmail.com.
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.affiliation: FIDMAG Hermanas Hospitalarias Research Foundation, Barcelona, Spain; CIBERSAM, Spain;
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McKenna
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000209:etiology / Q000534:rehabilitation*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000534:rehabilitation*; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000534:rehabilitation*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D017211:Treatment Failure; D055815:Young Adult
keywords: cognition; cognitive remediation; neuropsychology; schizophrenia