title: HEMODOSE: A Biodosimetry Tool Based on Multi-type Blood Cell Counts.
abstract: Peripheral blood cell counts are important biomarkers of radiation exposure. In this work, a simplified compartmental modeling approach is applied to simulate the perturbation of the hematopoiesis system in humans after radiation exposure, and HemoDose software is reported to estimate individuals' absorbed doses based on multi-type blood cell counts. Testing with patient data in some historical accidents indicates that either single or serial granulocyte, lymphocyte, leukocyte, and platelet counts after exposure can be robust indicators of the absorbed doses. In addition, such correlation exists not only in the early time window (1 or 2 d) but also in the late phase (up to 4 wk) after exposure, when the four types of cell counts are combined for analysis. These demonstrate the capability of HemoDose as a rapid point-of-care diagnostic or centralized high-throughput assay system for personnel exposed to unintended high doses of radiation, especially in large-scale nuclear/radiological disaster scenarios involving mass casualties.
authors.affiliation: *Wyle Laboratories, NASA Johnson Space Center, Houston, TX 77058; †Scientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889; ‡University of Nevada, Las Vegas, NV 89154.
authors.forename: Shaowen
authors.initials: S
authors.lastname: Hu
authors.forename: William F
authors.initials: WF
authors.lastname: Blakely
authors.forename: Francis A
authors.initials: FA
authors.lastname: Cucinotta
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001681:Biological Assay; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count; D002648:Child; D005260:Female; D006098:Granulocytes / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D007962:Leukocytes / Q000502:physiology / Q000528:radiation effects*; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011832:Radiation Injuries / Q000097:blood / Q000175:diagnosis*; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*; D014916:Whole-Body Irradiation; D055815:Young Adult
chemical_list: D015415:Biomarkers