title: Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population.
abstract: BACKGROUND
  Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2 (rs4290270, rs7305115 and rs1007023) genes and suicidal behavior in a Mexican population.
  
  
  METHODS
  We conducted a case-control study including 200 cases with suicide attempt and 263 controls. Patients were evaluated by a trained psychiatrist or clinical psychologists. Five polymorphisms were genotyped and assessed for allele, genotype and haplotype association with suicide attempt.
  
  
  RESULTS
  The rs7305115 polymorphism of the TPH-2 gene was associated with suicidal behavior in a Mexican population in genotype (χ(2)=6.02, df=2, p=0.04) and allele (OR=1.39, 95%IC=1.06-1.81, p=0.01) frequencies. The THP-2 haplotypes GTA (χ(2)=5.68, p=0.01) and ATT (χ(2)=5.0, p=0.02) were associated with risk for suicide attempt.
  
  
  CONCLUSIONS
  Our results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 gene and suicidal behavior in a Mexican population. However, more studies are necessary to replicate these results using larger samples.
authors.affiliation: Hospital General de Yajalón, Secretaria de Salud, Yajalón, Chiapas, México. Electronic address: dralilialonar@yahoo.com.mx.
authors.forename: María Lilia
authors.initials: ML
authors.lastname: López-Narváez
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, México. Electronic address: alfonso_tovillaz@yahoo.com.mx.
authors.forename: Carlos Alfonso
authors.initials: CA
authors.lastname: Tovilla-Zárate
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Tabasco, México. Electronic address: thelma.glez.castro@gmail.com.
authors.forename: Thelma Beatriz
authors.initials: TB
authors.lastname: González-Castro
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, México. Electronic address: iselajua22@yahoo.com.mx.
authors.forename: Isela
authors.initials: I
authors.lastname: Juárez-Rojop
authors.affiliation: Hospital General de Comalcalco, Tabasco, Secretaría de Salud, Comalcalco, Tabasco, México. Electronic address: shepoga70@hotmail.com.
authors.forename: Sherezada
authors.initials: S
authors.lastname: Pool-García
authors.affiliation: Instituto Nacional de Medicina Genómica (INMEGEN), Servicios de Atención Psiquiátrica (SAP), Secretaría de Salud, México, D. F., México. Electronic address: genis76@yahoo.com.
authors.forename: Alma
authors.initials: A
authors.lastname: Genis
authors.affiliation: Universidad Juárez Autónoma de Tabasco, División Académica de Ciencias de la Salud, Villahermosa, Tabasco, México. Electronic address: jblecastillo@hotmail.com.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Ble-Castillo
authors.affiliation: Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D. F., México. Electronic address: fresan@imp.edu.mx.
authors.forename: Ana
authors.initials: A
authors.lastname: Fresán
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D013406:Suicide, Attempted; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D055815:Young Adult
chemical_list: C497467:TPH1 protein, human; C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase