title: [Hypophysis-adrenal and thyroid secretion at law order staff depending on professional loading].
abstract: BACKGROUND
  A current etiological and pathogenic opinion about human health disturbance thereupon extreme factor effects is shown that this cause is principal mechanism of regulatory system (neuroimmunoendocrine complex) distress. In endocrine link occurs hormonal disbalance in hypothalamus-hypophysis axis, physiological interrelation disturbances in central-peripheral gland system (hypophysis-adrenal, hypophysis-thyroid) and metabolism abnormalities subsequently.
  
  
  OBJECTIVE
  Our aim was to determine the particular content of adrenocorticotropic and thyrothrophin hormone, cortisol, thyroxin and triiodthyronine features at law order staff in dependence from professional loading.
  
  
  METHODS
  It's provided two investigation series among law order staff groups--combatants, ordinary policemen and military school students. The investigation period for all people corresponds to combat mission beginning and its finish. In blood serum an adrenocorticotropic (ACTH) and thyrothrophin (TSH) hormone, cortisol, thyroxin (T) and triiodthyronine (T) levels were determined.
  
  
  RESULTS
  A higher ACTH and TSH levels detected at combatants in both investigation series. A cortisol, T4 and T3 at combatants before military mission were least in comparative with other groups, but after mission it indexes were largest.
  
  
  CONCLUSIONS
  Prolonged changes of endocrine secretory function that lead to hormonal disbalance can result to adaptation derangement. In connection with it in medical providing system for person that undergo extreme negative professional factors it's necessary create a special endocrine link with the view of organism resistance and life viability to extreme emergency factors and for prevention of pathological conditions.
authors.forename: R V
authors.initials: RV
authors.lastname: Koubassov
authors.forename: Yu E
authors.initials: YE
authors.lastname: Barachevsky
authors.forename: A M
authors.initials: AM
authors.lastname: Ivanov
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D006801:Humans; D008297:Male; D015213:Neuroimmunomodulation; D009784:Occupational Diseases / Q000209:etiology / Q000517:prevention & control; D016272:Occupational Health; D010902:Pituitary Gland / Q000503:physiopathology; D016495:Police; D012426:Russia; D013312:Stress, Physiological; D013961:Thyroid Gland / Q000473:pathology / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D000324:Adrenocorticotropic Hormone