title: Heteroatom-Guided, Palladium-Catalyzed, Site-Selective C-H Arylation of 4H-Chromenes: Diastereoselective Assembly of the Core Structure of Myristinin B through Dual C-H Functionalization.
abstract: A highly site-selective, heteroatom-guided, palladium-catalyzed direct arylation of 4H-chromenes is reported. The C-H functionalization is driven not only by the substituents and structure of the substrate but also by the coupling partner being used. The diastereoselective assembly of the core structure of Myristinin B has been achieved by using a dual C-H functionalization strategy for regioselective direct arylation.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, MP (India).
authors.forename: Govind Goroba
authors.initials: GG
authors.lastname: Pawar
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, MP (India).
authors.forename: Virendra Kumar
authors.initials: VK
authors.lastname: Tiwari
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, MP (India).
authors.forename: Himanshu Sekhar
authors.initials: HS
authors.lastname: Jena
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore Bypass Road, Bhauri, Bhopal 462066, MP (India). mk@iiserb.ac.in.
authors.forename: Manmohan
authors.initials: M
authors.lastname: Kapur
keywords: CH activation; arylation; chromenes; diastereoselectivity; oxygen heterocycles; palladium