title: Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis.
abstract: OBJECTIVE
  The objective of this systematic review is to provide an unprecedented summary of the prognostic impact of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma.
  
  
  METHODS
  Studies evaluating PAX3/7-FOXO1 fusion gene or its variants as a prognostic marker were systematically searched and comparative meta-analysis of overall survival was carried out.
  
  
  RESULTS
  A total of 7 studies comprising 993 patients with rhabdomyosarcoma were included. Three eligible studies showed no significant difference of survival between fusion positive and negative alveolar rhabdomyosarcoma. Four eligible studies showed that PAX3-FOXO1 fusion variant may indicate a lower survival probability than PAX7-FOXO1, although the effect did not reach a level of statistical significance (pooled hazard ratios, 1.66; 95% CI, 0.95-2.89; p=0.07).
  
  
  CONCLUSIONS
  There was no significant difference in the overall survival between patients with the positive and negative fusion gene, but there were indications of PAX3-FOXO1 being an unfavorable prognostic factor.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: kubot@hiroshima-u.ac.jp.
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Kubo
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Shimose
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Fujimori
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Furuta
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Ochi
mesh_terms: D000071161:Forkhead Box Protein O1 / Q000235:genetics*; D050939:Gene Fusion; D006801:Humans; D000072041:PAX3 Transcription Factor / Q000235:genetics*; D051763:PAX7 Transcription Factor / Q000235:genetics*; D011379:Prognosis; D016016:Proportional Hazards Models; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics* / Q000401:mortality
chemical_list: D000071161:Forkhead Box Protein O1; D000072041:PAX3 Transcription Factor; C489409:PAX3 protein, human; D051763:PAX7 Transcription Factor; C497321:PAX7 protein, human
keywords: Fusion gene; Meta-analysis; PAX3/7–FOXO1; Rhabdomyosarcoma; Survival