title: Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia.
abstract: OBJECTIVE
  Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats.
  
  
  METHODS
  Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores.
  
  
  RESULTS
  Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia.
  
  
  CONCLUSIONS
  Our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Guven
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Adem Bozkurt
authors.initials: AB
authors.lastname: Aras
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Tarik
authors.initials: T
authors.lastname: Akman
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Halil Murat
authors.initials: HM
authors.lastname: Sen
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Adile
authors.initials: A
authors.lastname: Ozkan
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Salis
authors.affiliation: Department of Pathology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sehitoglu
authors.affiliation: Department of Histology & Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Kalkan
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Coskun
authors.initials: C
authors.lastname: Silan
authors.affiliation: Department of Physiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Deniz
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Cosar
keywords: Apoptosis; Coumaric acids; Ischemia; Neuroprotective agents; Nuclear respiratory factor 1; Rats