title: [Historical overview and the current practice of intracavitary treatment of cervical and endometrial cancer in the Oncoradiology Center of Budapest].
abstract: The aims of our study were to describe the history and development of intracavitary brachytherapy in the treatment of gynecological tumors, to introduce our current practice for intracavitary brachytherapy treatments based on CT planning. Gynecological intracavitary brachytherapy has been applied in our department since the early 1930s. After a long development it has been completely renewed by 2014. In our center definitive and/or preoperative gynecological HDR-AL brachytherapy treatments were given to 25 patients (13 corpus uterine cancer patients and 12 cervical cancer patients) during the period of 01. 01. 2014-31. 01. 2015. In each case, target volumes were planned by CT images, DVH (dose volume histogram) analysis was performed in order to calculate the radiation tolerance dose of rectum and urinary bladder. Evaluation was performed by the EclipseTM 11.0.47. brachytherapy treatment planning system. During the definitive treatments of the 13 uterine cancer patients the D2cc value related to rectum tolerance was 66.3 GyEQD2 (46-91 Gy). The average D2cc value of urinary bladder tolerance was 76.5 GyEQD2 (30-112 Gy). CI was 0.72 (0.6-0.95). Average value of COIN was 0.57 (0.35-0.78). Compared to the prescribed dose D100 and D90 values were given in ratios. Compared to the volume which receives 100% of reference dose V150 and V200 values were also given in ratios. D100 and D90 were calculated to be 0.66 (0.47-0.97) and 0.91 (0.8-1.25). V150 and V200 volumes were 0.11 (0.04-0.18) and 0.06 (0.02-0.1). During the definitive treatments of 12 cervical cancer patients the D2cc value related to rectum tolerance calculated by DVH was 75.2 GyEQD2 (60-82 Gy). The average D2cc value of urinary bladder tolerance was 85 GyEQD2 based on DVH. CI was 0.66 (0.42-0.76). Average value of COIN was 0.52 (0.32-0.78). Mean value of DHI was 0.46 (0.27-0.54). D100 and D90 were calculated to be 0.72 (0.57-0.89) and 0.91 (0.84-1.11). V150 and V200 volumes were 0.057 (0.02-0.13) and 0.02 (0.002-0.06). During treatments no severe side effects were found. During gynecological intracavitary HDR therapies the calculated dose of the target volume can be given safely using the EclipseTM 11.0.47. brachytherapy planning system and CT-based planning. CT-based treatment planning provides optimal safety for organs at risk, acceptable doses for rectum and urinary bladder while the target volume receives the proper prescribed dose.
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: Dániel
authors.initials: D
authors.lastname: Sinkó
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: Csaba
authors.initials: C
authors.lastname: Nemeskéri
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Pallinger
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: Csaba
authors.initials: C
authors.lastname: Weisz
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: Attila
authors.initials: A
authors.lastname: Naszály
authors.affiliation: Fõvárosi Onkoradiológiai Központ, Uzsoki Utcai Oktató Kórház, Budapest, Hungary. sinkodaniel@yahoo.com.
authors.forename: László
authors.initials: L
authors.lastname: Landherr
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000266:history / Q000295:instrumentation* / Q000379:methods / Q000639:trends*; D002173:Cancer Care Facilities / Q000266:history / Q000639:trends*; D019583:Dose Fractionation, Radiation; D016889:Endometrial Neoplasms / Q000532:radiotherapy; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006814:Hungary; D008279:Magnetic Resonance Imaging; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control*; D018787:Radiation Oncology / Q000266:history / Q000295:instrumentation / Q000379:methods* / Q000639:trends*; D061089:Radiotherapy, Image-Guided / Q000639:trends; D012007:Rectum / Q000528:radiation effects; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden; D001743:Urinary Bladder / Q000528:radiation effects; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy; D014594:Uterine Neoplasms / Q000266:history / Q000532:radiotherapy*