title: GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration.
abstract: Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insulin‑like growth factor (IGF)/IGF‑1 receptor (IGF‑1R) signaling pathway regulates cell proliferation, motility and survival. The dysregulation of this signaling pathway has been implicated in the development of malignant gliomas. In the present study, GSK1904529A, a small molecule inhibitor of IGF‑1R, suppressed glioma cell viability, induced glioma cell apoptosis and inhibited glioma cell migration in vitro. In addition, GSK1904529A inhibited glioma tumor growth and induced tumor cell apoptosis in vivo. In conclusion, the results of the present study suggested GSK1904529A as a promising agent for the treatment of malignant glioma.
authors.affiliation: Department of Pathology, Children's Hospital of Zhengzhou, Zhengzhou, Henan 450052, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Junxia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Qinying
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Ophthalmology, People's Hospital of Zhengzhou, Zhengzhou, Henan 450012, P.R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Physiology, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.affiliation: Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011725:Pyridines / Q000494:pharmacology*; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors*; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; C000607695:GSK1904529A; D007093:Imidazoles; D011725:Pyridines; D017526:Receptor, IGF Type 1