title: [Treatment of neoplastic lesions of the central bronchi and trachea using endotracheobronchial surgery, intraluminal brachytherapy, combined radiotherapy and chemoradiotherapy].
abstract: There are summarized the foreign and domestic references of recent years devoted to methodology and the efficiency of the use of intraluminal high-dose radiation brachytherapy in patients with lesions of the central bronchi and trachea caused by primary and metastatic malignant tumors. It is presented own experience of applying this method in 207 patients. It is showed that in some patients to ensure the delivery of the radiation source to the area of interest it is advisable to perform firstly endotraheobronhial surgery with recanalization of the lumen of the respiratory pathways. The best is the use of intraluminal brachytherapy with high dose radiation. Palliative intraluminal irradiation of inoperable patients allowed achieving a good immediate results (65-95%), a significant reduction of the main symptoms--hemoptoe (87-95%), dyspnea (75-90%), obstructive pneumonia phenomena (50-85%), and significantly increasing survival median from 1-3 to 9-14 months. Following performance of chemoradiotherapy permitted increasing the survival median up to 15-20 months. The number of complications of intraluminal high-dose radiation brachytherapy was small, usually--pulmonary hemorrhage (2-7%) more likely developing when using large fractions--more than 10 g for 1 session.
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: A I
authors.initials: AI
authors.lastname: Arseniev
authors.forename: A S
authors.initials: AS
authors.lastname: Barchuk
authors.forename: K E
authors.initials: KE
authors.lastname: Gagua
authors.forename: A A
authors.initials: AA
authors.lastname: Barchuk
authors.forename: M L
authors.initials: ML
authors.lastname: Gelfond
authors.forename: A V
authors.initials: AV
authors.lastname: Shulepov
authors.forename: T N
authors.initials: TN
authors.lastname: Shuginova
authors.forename: V G
authors.initials: VG
authors.lastname: Preis
authors.forename: S A
authors.initials: SA
authors.lastname: Tarkov
authors.forename: A O
authors.initials: AO
authors.lastname: Nefedov
authors.forename: K A
authors.initials: KA
authors.lastname: Kostitsyn
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D059186:Chemoradiotherapy, Adjuvant; D003452:Cryosurgery; D004334:Drug Administration Schedule; D004598:Electrosurgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D015607:Stents; D016019:Survival Analysis; D014134:Tracheal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome