title: Stimulation of Proliferation and Differentiation of Rat Resident Myocardial Cells with Apoptotic Bodies of Cardiomyocytes.
abstract: Using the cell model of regenerative cardiomyogenesis (formation of contracting cardiomyocyte colonies from resident stem cells), we found that the addition of cardiomyocyte-derived apoptotic bodies to the culture of neonatal myocardial cells stimulated proliferation and differentiation of cardiomyocyte precursors and the frequency of their contraction was 1.5-fold higher than in the control. Systemic administration of cardiomyocyte-derived apoptotic bodies to Wistar rats with chronic postinfarction heart failure during the early period of myocardial remodeling considerably improved the contractile function of the heart.
authors.affiliation: V. A. Almazov Federal Center for Heart, Blood, and Endocrinology, St. Petersburg, Russia, atuykavin@mail.ru.
authors.forename: A I
authors.initials: AI
authors.lastname: Tyukavin
authors.forename: G B
authors.initials: GB
authors.lastname: Belostotskaya
authors.forename: T A
authors.initials: TA
authors.lastname: Golovanova
authors.forename: M M
authors.initials: MM
authors.lastname: Galagudza
authors.forename: E A
authors.initials: EA
authors.lastname: Zakharov
authors.forename: N V
authors.initials: NV
authors.lastname: Burkova
authors.forename: D Yu
authors.initials: DY
authors.lastname: Ivkin
authors.forename: A A
authors.initials: AA
authors.lastname: Karpov
mesh_terms: D000818:Animals; D064752:Atrial Remodeling / Q000502:physiology; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002478:Cells, Cultured; D000067128:Extracellular Vesicles / Q000378:metabolism*; D006333:Heart Failure / Q000628:therapy*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000502:physiology