title: Macular retinal sensitivity using MP-1 in healthy Malaysian subjects of different ages.
abstract: OBJECTIVE
  To determine the influence of age and gender on macular sensitivity to light in healthy subjects of 4 age groups using the MP-1 microperimeter.
  
  
  METHODS
  A prospective study was carried out on 50 healthy subjects (age range: 18-60 years) divided into 4 age groups; 18-30 years, 31-40 years, 41-50 years and 51-60 years. Full-threshold microperimetry of the central 10° of retina was performed utilizing 32 points with the MP-1. Macula area was divided into four quadrants, which were superior nasal (SN), inferior nasal (IN), inferior temporal (IT) and superior temporal (ST).
  
  
  RESULTS
  Total mean sensitivity at 10° for age groups 18-30 years, 31-40 years, 41-50 years and 51-60 years were 19.46 ± 0.30, 19.40 ± 0.39, 19.47 ± 0.35 and 18.73 ± 0.75 (dB), respectively. There was a significant difference in total mean retinal sensitivity at 10° and at the four quadrants with age but not for gender. The retinal sensitivity was highest in the IT quadrant and lowest in the SN quadrant for all age groups. The linear regression analysis revealed that there was a 0.019 dB, 0.016 dB, 0.022 dB, 0.029 dB and 0.029 dB per year age-related decline in mean macular sensitivity within the central 10° diameter in the SN, IN, IT and ST quadrants respectively.
  
  
  CONCLUSIONS
  Among normal healthy subjects, there was a linear decline in retinal light sensitivity with increasing age with the highest reduction in the superior nasal quadrant and lowest in the inferior temporal quadrant.
authors.affiliation: Optometry & Vision Science Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Siti Aishah
authors.initials: SA
authors.lastname: Ismail
authors.affiliation: Optometry & Vision Science Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. Electronic address: sharanjeet@ukm.edu.my.
authors.lastname: Sharanjeet-Kaur
authors.affiliation: Optometry & Vision Science Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Haliza Abdul
authors.initials: HA
authors.lastname: Mutalib
authors.affiliation: Department of Ophthalmology, Hospital Selayang, Lebuhraya Selayang, Kepong, 68100 Batu Caves, Malaysia.
authors.forename: Nor Fariza
authors.initials: NF
authors.lastname: Ngah
mesh_terms: D000328:Adult; D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D044466:Asian People; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000502:physiology*; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011446:Prospective Studies; D012684:Sensory Thresholds / Q000502:physiology; D012737:Sex Factors; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult
keywords: Age; Edad; MP-1; Microperimetry; Microperimetría; Retinal sensitivity; Sensibilidad retiniana