title: Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD).
abstract: Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6 mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6 mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6 mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.
authors.affiliation: Arizona State University, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Watterson
authors.affiliation: Arizona State University, United States.
authors.forename: Carter W
authors.initials: CW
authors.lastname: Daniels
authors.affiliation: Arizona State University, United States; Center for Substance Abuse Research, Temple University School of Medicine, United States.
authors.forename: Lucas R
authors.initials: LR
authors.lastname: Watterson
authors.affiliation: Arizona State University, United States.
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Mazur
authors.affiliation: Arizona State University, United States.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Brackney
authors.affiliation: Arizona State University, United States.
authors.forename: M Foster
authors.initials: MF
authors.lastname: Olive
authors.affiliation: Arizona State University, United States. Electronic address: Federico.Sanabria@asu.edu.
authors.forename: Federico
authors.initials: F
authors.lastname: Sanabria
mesh_terms: D000375:Aging; D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology*; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013037:Spatial Behavior / Q000187:drug effects* / Q000502:physiology; D013045:Species Specificity
chemical_list: D005731:Ganglionic Stimulants; D009538:Nicotine
keywords: Adolescence; Attention deficit/hyperactivity disorder (ADHD); Locomotor Behavior; Nicotine; Reward; Spontaneously hypertensive rat (SHR)