title: Successful treatment of intra-abdominal eumycotic mycetoma caused by Penicillium duponti in a dog.
abstract: A 2-year-old female neutered golden retriever was presented for investigation of an intra-abdominal mass. Computed tomography revealed a mass associated with the caudal pole of the right kidney. Incisional biopsy findings were consistent with eumycotic mycetoma. The mass was subsequently removed in conjunction with right ureteronephrectomy. Two years later, the dog re-presented with a splenic mass and fungal plaques located throughout the peritoneum. Splenectomy was performed and the mass was diagnosed as eumycotic mycetoma caused by Penicillium duponti. Indefinite systemic treatment with 10 mg/kg itraconazole orally once a day was initiated. Thirty-two months after the last surgery, there were no clinical signs apart from mild polydipsia. Haematology and biochemistry results were unremarkable. To the authors' knowledge, this is the first report of successful treatment of intra-abdominal eumycotic mycetoma with a combination of surgery and systemic antifungal therapy in the dog. Penicillium duponti has not apparently been reported to cause disease in animals or humans.
authors.affiliation: VRCC Veterinary Referrals, No. 1 Bramston Way, Laindon, Essex, SS15 6TP.
authors.forename: J
authors.initials: J
authors.lastname: Janovec
authors.affiliation: VRCC Veterinary Referrals, No. 1 Bramston Way, Laindon, Essex, SS15 6TP.|Department of Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Brockman
authors.affiliation: VRCC Veterinary Referrals, No. 1 Bramston Way, Laindon, Essex, SS15 6TP.|Department of Pathology and Pathogen Biology, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA.
authors.forename: S L
authors.initials: SL
authors.lastname: Priestnall
authors.affiliation: VRCC Veterinary Referrals, No. 1 Bramston Way, Laindon, Essex, SS15 6TP.|Department of Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire, AL9 7TA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Kulendra
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D004285:Dogs; D005260:Female; D017964:Itraconazole / Q000627:therapeutic use; D008271:Mycetoma / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000662:veterinary*; D010407:Penicillium; D014057:Tomography, X-Ray Computed / Q000662:veterinary
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole