title: Phytotrapy of cyclophosphamide-induced immunosuppression.
abstract: Cyclophosphamide (CP) is a cytotoxic drug that can suppress both humoral and cellular immunity. Combining traditional medicinal herbs and chemotherapy drugs are used to improve immunity and quality of life performance status. In this paper, the effects of plant extracts, active components and their derivatives on immunosuppression of CP are discussed. Appropriate keywords were used to search through PubMed, Google Scholar, and Sciverse. All relevant results published from 1990 to date were chosen for final review. Over 50 references were found in which plant extracts, active components and their derivatives have been tested for their immune protective effects against CP-induced immune toxicity. Although there are several plants shown to be effective in animal models, no study was carried out on human subjects. According to the results; we can claim that plants and their active ingredients are good candidates for alternative adjuvant chemotherapy in reducing the immunotoxicity of CP.
authors.affiliation: Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kobra
authors.initials: K
authors.lastname: Shirani
authors.affiliation: Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Faezeh Vahdati
authors.initials: FV
authors.lastname: Hassani
authors.affiliation: Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kamal
authors.initials: K
authors.lastname: Razavi-Azarkhiavi
authors.affiliation: Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Heidari
authors.affiliation: Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Bamdad Riahi
authors.initials: BR
authors.lastname: Zanjani
authors.affiliation: Medical Toxicology Research Center and Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Karimig@mums.ac.ir.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Karimi
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D016206:Databases, Bibliographic; D006801:Humans; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D007166:Immunosuppressive Agents; D010936:Plant Extracts; D003520:Cyclophosphamide
keywords: Cyclophosphamide; Herbal; Immunotoxicity; Phytotherapy; Protect