title: Primary A (H1N1) pdm09 Influenza Pneumonia Diagnosed on Reverse Transcription-polymerase Chain Reaction (RT-PCR) of Bronchoalveolar Lavage Fluid but not Rapid Tests with Nasopharyngeal Swabs.
abstract: A 47-year-old man with a fever was highly suspected of having influenza A infection since his wife and son who lived with him had been diagnosed with influenza A. Although repeated rapid tests with a nasopharyngeal swab showed negative findings, the patient developed bilateral pneumonia and reverse transcription polymerase chain reaction (PCR) for A (H1N1) pdm09 virus in the bronchoalveolar lavage fluid was positive. We therefore diagnosed him with primary influenza pneumonia and initiated treatment with peramivir plus corticosteroids, which rapidly improved his condition. During the influenza season, sample collection from the lower airway and PCR should be considered for the definitive diagnosis of primary influenza viral pneumonia.
authors.affiliation: Division of Respiratory Medicine, Ishikawa Prefectural Central Hospital, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ohkura
authors.forename: Mayuko
authors.initials: M
authors.lastname: Tani
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishitsuji
authors.forename: Koichi
authors.initials: K
authors.lastname: Nishi
mesh_terms: D000146:Acids, Carbocyclic; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D003517:Cyclopentanes / Q000627:therapeutic use; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D000146:Acids, Carbocyclic; D000305:Adrenal Cortex Hormones; D003517:Cyclopentanes; D006146:Guanidines; C414210:peramivir