title: Synthesis and antioxidant activity of some 1-aryl/aralkyl piperazine derivatives with xanthine moiety at N4.
abstract: Piperazine nucleus is one of the most important heterocyclic systems exhibiting remarkable pharmacological activities. Thus, in the current study six new aryl/aralkyl substituted piperazine derivatives, containing methylxanthine moiety were synthesized and their structures were confirmed by IR and1H NMR analysis. All compounds werein vitroscreened for their activity as antioxidants using DPPH (2,2'-Diphenyl-1-picrylhydrazyl), ABTS (2,2'-azinobis-(3-ethylbenzo thiazine-6-sulfonic acid)) and FRAP (ferric reducing/antioxidant power) methods. The antioxidant activity of the studied compounds against lipid peroxidation was also measured. The highest antioxidant activity was demonstrated by compound 3c. It is obvious that the presence of a hydroxyl group in the structure is essential for the antioxidant properties and should be taken into consideration in further design of structures with potential antioxidant properties.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Medical University of Sofia, 2 Dunav Street, 1000 Sofia , Bulgaria.
authors.forename: Lily
authors.initials: L
authors.lastname: Andonova
authors.affiliation: Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy , Medical University of Sofia, 2 Dunav Street, 1000 Sofia , Bulgaria.
authors.forename: Dimitrina
authors.initials: D
authors.lastname: Zheleva-Dimitrova
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Medical University of Sofia, 2 Dunav Street, 1000 Sofia , Bulgaria.
authors.forename: Maya
authors.initials: M
authors.lastname: Georgieva
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Medical University of Sofia, 2 Dunav Street, 1000 Sofia , Bulgaria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Zlatkov
keywords: 1-aryl/aralkyl piperazines; antioxidant activity; xanthine