title: Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
abstract: OBJECTIVE
  Fibroscan (FS) is a reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in chronic liver disease. However, there is no clear consensus with respect to the best FS cut-off values for use in alcoholic liver disease (ALD). The aims of this study were as follows: (a) to compare the performance of FS and different biochemical markers in ALD patients; (b) to assess the best FS cut-off values for the prediction of fibrosis stage in our ALD population; and (c) to assess the influence of aspartate aminotransferase (AST) values on FS.
  
  
  METHODS
  This retrospective study included 135 consecutive and compensated ALD patients who underwent liver biopsy between November 2006 and March 2012 at Erasme Hospital. FS, Fibrotest, FIB-4, aspartate aminotransferase to platelet ratio index (APRI), and Forns' scores were tested in all patients.
  
  
  RESULTS
  The diagnostic accuracy of FS was 0.89 (95% confidence interval: 0.83-0.95) for the diagnosis of advanced fibrosis and 0.93 (95% confidence interval 0.90-0.97) for the diagnosis of cirrhosis. FS performed better than Fibrotest (0.81 and 0.88), APRI (0.65 and 0.75), Forns' (0.64 and 0.78), and FIB-4 (0.70 and 0.73). The optimal cut-off values of liver stiffness (LS) for predicting METAVIR fibrosis stage F≥3 and F4 disease were 10.3 and 18.0 kPa, respectively. AST showed a significant positive correlation with LS (r=0.24, P=0.001). However, exclusion of patients with AST more than 50 IU/l only lowered the LS cut-off for the diagnosis of F4 (14 vs. 18.0 kPa).
  
  
  CONCLUSIONS
  FS is currently the most reliable noninvasive method for the diagnosis of advanced liver fibrosis and cirrhosis in ALD.
authors.affiliation: aLiver unit, Department of Gastroenterology, Hepatopancreatology and Digestive Oncology bDepartment of Pathology, Erasme Hospital cLaboratory of Experimental Gastroenterology, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Michael
authors.initials: M
authors.lastname: Fernandez
authors.forename: Eric
authors.initials: E
authors.lastname: Trépo
authors.forename: Delphine
authors.initials: D
authors.lastname: Degré
authors.forename: Thierry
authors.initials: T
authors.lastname: Gustot
authors.forename: Laurine
authors.initials: L
authors.lastname: Verset
authors.forename: Pieter
authors.initials: P
authors.lastname: Demetter
authors.forename: Jacques
authors.initials: J
authors.lastname: Devière
authors.forename: Michael
authors.initials: M
authors.lastname: Adler
authors.forename: Christophe
authors.initials: C
authors.lastname: Moreno
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D001530:Belgium; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D004796:Clinical Enzyme Tests; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000201:enzymology / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases