title: A novel brain partition highlights the modular skeleton shared by structure and function.
abstract: Elucidating the intricate relationship between brain structure and function, both in healthy and pathological conditions, is a key challenge for modern neuroscience. Recent progress in neuroimaging has helped advance our understanding of this important issue, with diffusion images providing information about structural connectivity (SC) and functional magnetic resonance imaging shedding light on resting state functional connectivity (rsFC). Here, we adopt a systems approach, relying on modular hierarchical clustering, to study together SC and rsFC datasets gathered independently from healthy human subjects. Our novel approach allows us to find a common skeleton shared by structure and function from which a new, optimal, brain partition can be extracted. We describe the emerging common structure-function modules (SFMs) in detail and compare them with commonly employed anatomical or functional parcellations. Our results underline the strong correspondence between brain structure and resting-state dynamics as well as the emerging coherent organization of the human brain.
authors.affiliation: Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain.
authors.forename: Ibai
authors.initials: I
authors.lastname: Diez
authors.affiliation: School of Physics and Astronomy, George S. Wise Faculty of Life Sciences, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonifazi
authors.affiliation: 1] Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain [2] Radiology Service, Cruces University Hospital, Barakaldo, Spain.
authors.forename: Iñaki
authors.initials: I
authors.lastname: Escudero
authors.affiliation: 1] Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain [2] Radiology Service, Cruces University Hospital, Barakaldo, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Mateos
authors.affiliation: Departamento de Electromagnetismo y Física de la Materia and Instituto Carlos I de Física Teórica y Computacional, Universidad de Granada, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Muñoz
authors.affiliation: 1] Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain [2] Dipartimento di Fisica, Universita degli Studi di Bari and INFN, Bari, Italy [3] Ikerbasque: The Basque Foundation for Science, Bilbao, Spain.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Stramaglia
authors.affiliation: 1] Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Spain [2] Ikerbasque: The Basque Foundation for Science, Bilbao, Spain [3] Department of Cell Biology and Histology. University of the Basque Country. Leioa, Spain.
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Cortes
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D016000:Cluster Analysis; D063132:Connectome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D055815:Young Adult