title: Both hepatic and body iron stores are increased in dysmetabolic iron overload syndrome. A case-control study.
abstract: OBJECTIVE
  Hepatic iron is increased in dysmetabolic iron overload syndrome (DIOS). Whether this reflects elevated body iron stores is still debated. The study was aimed at assessing body iron stores in DIOS patients by calculating the amount of mobilized iron (AMI).
  
  
  METHODS
  We conducted a prospective case-control study comparing AMI in 12 DIOS patients and 12 overweight normoferritinemic subjects matched on BMI and age. All participants were phlebotomized until serum ferritin dropped ≤ 50μg/L.
  
  
  RESULTS
  The two groups were comparable with respect to metabolic abnormalities and differed according to serum ferritin levels only. AMI was significantly (p<0.0001) higher in DIOS (2.5g±0.7) than in controls (0.8g±0.3). No side effects were related to phlebotomies.
authors.affiliation: CHU Rennes, Liver Unit, F-35033, Rennes, France; INSERM, CIC 1414, F-35033, Rennes, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Jézéquel
authors.affiliation: CHU Rennes, Liver Unit, F-35033, Rennes, France; INSERM, CIC 1414, F-35033, Rennes, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Lainé
authors.affiliation: INSERM, CIC 1414, F-35033, Rennes, France; University Rennes 1, Faculty of Medicine, F- 35043, Rennes, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Laviolle
authors.affiliation: INSERM, CIC 1414, F-35033, Rennes, France; CHU Rennes, Department of Radiology, F-35033, Rennes, France.
authors.forename: Anita
authors.initials: A
authors.lastname: Kiani
authors.affiliation: CHU Rennes, Liver Unit, F-35033, Rennes, France; INSERM, CIC 1414, F-35033, Rennes, France; INSERM, U991, F-35033, Rennes, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Bardou-Jacquet
authors.affiliation: CHU Rennes, Liver Unit, F-35033, Rennes, France; INSERM, CIC 1414, F-35033, Rennes, France; University Rennes 1, Faculty of Medicine, F- 35043, Rennes, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Deugnier
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D019190:Iron Overload / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies