title: New oral anticoagulant and antiplatelet agents for neurosurgeons.
abstract: Until recently, warfarin, clopidogrel and aspirin have provided the mainstay for prevention of thrombotic disease in cardiac patients. However, new classes of drugs have recently emerged that promise better clinical outcomes and lower risks. Use of such agents has increased, but increased risk and severity of intra-cranial haemorrhage (ICH) still remain. These cases of intra-cranial bleeds present as emergencies to neurosurgical units. It is of paramount importance that neurosurgical practitioners are aware of those new drugs, useful monitoring tests and available emergency reversal options in case the patient needs emergency intervention. In this review we survey newly available agents in the U.K. at the time of publication. We look at the data provided by the manufacturers, related publications and international guidelines for their use and reversal. New anticoagulants offer a lower incidence of ICH compared with warfarin. Advanced and accurate monitoring tests are emerging, as are prospective data on reversal of anticoagulation in bleeding. Some standard coagulation tests may be of use, whilst reversal agents are available and being evaluated. The trial data shows that new antiplatelet agents have similar or increased incidence and severity of intra-cranial ICH compared with clopidogrel. There is currently limited data on monitoring or reversal. We suggest they may be managed similarly to clopidogrel by using platelet reactivity assays, optimising platelet count and using platelet transfusion with adjunctive agents.
authors.affiliation: a Cardiff University School of Medicine, Heath Park , Cardiff , Wales , UK.
authors.forename: George
authors.initials: G
authors.lastname: Kimpton
authors.affiliation: b Department of Neurosurgery , University Hospital of Wales , Cardiff , Wales , UK.
authors.forename: Bassam
authors.initials: B
authors.lastname: Dabbous
authors.affiliation: b Department of Neurosurgery , University Hospital of Wales , Cardiff , Wales , UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Leach
mesh_terms: D004632:Emergency Medical Services; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced*; D000069471:Neurosurgeons; D009493:Neurosurgery / Q000379:methods* / Q000639:trends; D019635:Neurosurgical Procedures / Q000379:methods*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: antiplatelets; intra-cranial haemorrhage; neurosurgery; novel oral anticoagulants