title: Risk for prolonged QT interval and associated outcomes in children with early restrictive eating patterns.
abstract: Aim This study aimed to describe the frequency of QTc prolongation in children with restrictive eating disorders early in the course of disease admitted for inpatient therapy, to determine the frequency of associated ventricular arrhythmia, and to evaluate the relationship between QTc interval and concomitant electrolyte abnormalities and rate of weight loss.
  
  
  METHODS
  This was a retrospective cohort study of patients aged 11-25 years with early restrictive eating disorders.
  
  
  RESULTS
  In all, 82 patients met the inclusion criteria (84% female). In total, 9.8% had prolonged QTc interval during hospitalisation. Patients with prolonged QTc had significantly higher resting heart rates (p=0.006), but there was no association with hypokalaemia (p=0.31), hypomagnesaemia (p=0.43), hypophosphataemia (p=1), or rate of weight loss (p=1).
  
  
  CONCLUSIONS
  Mild QTc prolongation in patients with restrictive eating disorders is not related to electrolyte abnormalities or rate of weight loss in this population, suggesting that investigation about other potential risk factors of prolonged QTc interval may be warranted.
authors.affiliation: 1Department of Cardiology,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
authors.forename: Karine
authors.initials: K
authors.lastname: Guerrier
authors.affiliation: 2Division of Adolescent and Transition Medicine,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
authors.forename: Laurie
authors.initials: L
authors.lastname: Mitan
authors.affiliation: 3Division of Biostatistics and Epidemiology,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1Department of Cardiology,Cincinnati Children's Hospital Medical Center,Cincinnati,Ohio,United States of America.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Czosek
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Anorexia nervosa; eating disorder; long QT; prolonged QT; restrictive eating