title: MiR-506: A Multitasker in Suppression of the Epithelial-to-Mesenchymal Transition.
abstract: MiRNAs emerge as important regulators of epithelial-to-mesenchymal transition (EMT). The Best known EMT regulatory miRNAs are targeting the transcriptional repressors of E-cadherin (E-cad). We identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor, SNAI2. Our recent studies showed that miR-506 simultaneously suppresses vimentin and N-cad. Thus, miR-506 possesses a multitasking property in the suppression of EMT and metastasis and thus may represent a promising tool in cancer therapeutics.
authors.affiliation: Departments of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionaledei Tumori, Milan, Italy.
authors.forename: Delia
authors.initials: D
authors.lastname: Mezzanzanica
authors.affiliation: Departments of Pathology,The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
keywords: N-cadherin; epithelial ovarian cancer; epithelial-to-mesenchymal transition; miR-506; nanoparticle; vimentin