title: Efficacy of the Mirasol pathogen reduction technology system against severe fever with thrombocytopenia syndrome virus (SFTSV).
abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tickborne virus in the Bunyaviridae family. This virus has recently been found in China, Japan and Korea. The risk of transfusion-transmitted SFTSV infection (TTI-SFTSV) is a concern because person-to-person transmission resulting from contact with SFTSV-contaminated blood has been reported. Therefore, we investigated the efficacy of the Mirasol pathogen reduction technology (PRT) system for inactivating SFTSV in vitro. The Mirasol PRT system achieved a > 4.11 log10 reduction value (LRV) for SFTSV. In conclusion, we showed that the Mirasol PRT system could potentially be used to reduce the risk of TTI-SFTSV.
authors.affiliation: Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shinohara
authors.affiliation: Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Matsumoto
authors.affiliation: Kanto-Koshinetsu Block Blood Center, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Chatani
authors.affiliation: Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uchida
authors.affiliation: Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases, Musashimurayama-shi, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases, Musashimurayama-shi, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimojima
authors.affiliation: Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Satake
authors.affiliation: Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D058731:Blood Safety / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D016856:Phlebovirus / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000998:Antiviral Agents
keywords: Mirasol PRT System; pathogen reduction technology; platelet concentrate; severe fever with thrombocytopenia