title: [Metabolic therapy of nephrolithiasis in two different rat models of kidney disease].
abstract: 108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotective effect upon the development of this disease. "Ethyleneglycol" model consisted of adding 1% ethylene glycol solution in drinking water for 37 days and "fructose-induced" one--of adding 10% fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The "ethyleneglycol" model proved to cause maximum changes while the "Fructose-induced" model--only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.
authors.forename: A P
authors.initials: AP
authors.lastname: Trashkov
authors.forename: A G
authors.initials: AG
authors.lastname: Vasiliev
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
authors.forename: N S
authors.initials: NS
authors.lastname: Tagirov
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood / Q000652:urine; D004195:Disease Models, Animal; D019855:Ethylene Glycol / Q000633:toxicity; D005632:Fructose / Q000494:pharmacology; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000652:urine; D008297:Male; D053040:Nephrolithiasis / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy* / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar; D013386:Succinates / Q000494:pharmacology*; D013549:Sweetening Agents / Q000009:adverse effects / Q000494:pharmacology; D014508:Urea / Q000097:blood / Q000652:urine
chemical_list: C555877:Remaxol; D013386:Succinates; D013549:Sweetening Agents; D005632:Fructose; D014508:Urea; D003404:Creatinine; D019855:Ethylene Glycol