title: [Individualized therapy of synchronous ovarian and colon cancers with lymph].
abstract: A 71-year-old female patient underwent urgent laparotomy due to severe right lower quadrant abdominal pain and fever. Macroscopically duplex coecal and transverse colon cancer as well as a sigmoid or left ovarian cancer were suspected. Pathological findings revealed synchronous left ovarian and transverse colonic neoplasms. Both primaries metastatized to their regional lymph nodes. Furthermore, the ovarian cancer infiltrating the sigmoid colon gave distant metastasis in the coecum, too. Ovarian cancer histology showed papillary adenocarcinoma, and transverse colon cancer was a tubular adenocarcinoma. The affected lymph nodes were clearly distinguished by immunohistochemistry staining: ovarian metastases were CK7 positive, and colonic metastases were CK20 and CEA positive. The patient was treated with combinated chemotherapy: FOLFOX-4 two weekly and paclitaxel monotherapy every other week. The patient tolerated this combined treatment well. The authors conclude that multiple synchronous neoplasms can be treated with individualized chemotherapeutic protocol with good efficacy and few adverse reactions.
authors.affiliation: Onkológia, Szent Lázár Megyei Kórház Salgótarján, Füleki út 54-56., 3100.
authors.forename: Dániel
authors.initials: D
authors.lastname: Deme
authors.forename: Abdulfatah M
authors.initials: AM
authors.lastname: Bishr
authors.forename: Jamool
authors.initials: J
authors.lastname: Nizar
authors.forename: András
authors.initials: A
authors.lastname: Telekes
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000230:Adenocarcinoma / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D000231:Adenocarcinoma, Papillary / Q000628:therapy; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D004334:Drug Administration Schedule; D005260:Female; D005334:Fever / Q000209:etiology; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20 / Q000032:analysis; D053552:Keratin-7 / Q000032:analysis; D007813:Laparotomy; D002955:Leucovorin / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D057285:Precision Medicine; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053554:Keratin-20; D053552:Keratin-7; D009944:Organoplatinum Compounds; D017239:Paclitaxel; D002955:Leucovorin; D005472:Fluorouracil
keywords: colon cancer; combined chemotherapy; kombinált kemoterápia; lymph node positivity; nyirokcsomó-pozitivitás; synchronous ovarian cancer; szinkrón petefészek-daganat; vastagbéldaganat