title: A detachable ester bond enables perfect Z-alkylations of olefins for the synthesis of tri- and tetrasubstituted alkenes.
abstract: 2-Vinyl-substituted phenol and an alpha-bromoester undergo a tandem esterification-alkylation reaction in the presence of a Cu-amine catalyst system to produce benzene-fused lactone. Z-Alkylated styrene is obtained after hydrolysis of the lactone with perfect selectivity. The simple protocol developed in this work opens a new avenue in the multi-substitution chemistry of alkenes.
authors.affiliation: Graduate School of Science and Engineering, Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi, 755-8611, Japan. nisikata@yamaguchi-u.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishikata
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishikawa