title: Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover.
abstract: The present study aimed to examine the effects polysaccharide-rich extract of Acanthopanax senticosus (PEA) on blood alcohol concentration (BAC) and hangover as well as blood lab parameters. A randomized, placebo-controlled, double-blind crossover trial was conducted. The PEA was orally administered before and after consuming alcohol 1.75 g/kg of pure alcohol. After alcohol consumption, BAC was measured for evaluation of alcohol pharmacokinetics. In the second day morning, subjects were asked to complete the Acute Hangover Scale (AHS) questionnarie. BAC results showed little difference between placebo and PEA groups, indicating that PEA does not have an effect on the pharmacokinetics of alcohol. However, several AHS items (i.e., tired, headache, dizziness, stomachache and nausea) and AHS total score were significantly improved by PEA. Blood lab parameters were significantly altered by alcohol in the placebo group. The alteration by alcohol of glucose and C-reactive protein (CRP) level was significantly attenuated by PEA. Therefore, PEA may have potential to reduce the severity of the alcohol hangover by inhibiting the alcohol-induced hypoglycemia and inflammatory response.
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Bang
authors.forename: Yoon Hee
authors.initials: YH
authors.lastname: Chung
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Chung
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Lee
authors.forename: Eun Ho
authors.initials: EH
authors.lastname: Song
authors.forename: Yong Kyoo
authors.initials: YK
authors.lastname: Shin
authors.forename: Yu Jeung
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hyoung-Chun
authors.initials: HC
authors.lastname: Kim
authors.forename: Yunsung
authors.initials: Y
authors.lastname: Nam
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Jeong
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000523:psychology; D002492:Central Nervous System Depressants / Q000097:blood; D018592:Cross-Over Studies; D004311:Double-Blind Method; D028001:Eleutherococcus / Q000737:chemistry*; D000431:Ethanol / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002492:Central Nervous System Depressants; D010936:Plant Extracts; D011134:Polysaccharides; D000431:Ethanol