title: [A case of growing teratoma syndrome; long-term control accomplished by systemic interferon therapy with adequate local therapies].
abstract: A 31-year-old man came to our hospital with chest pain and was diagnosed to have a left testicular tumor with metastasis to the lung, and cervical, mediastinal, and retroperitoneal lymph nodes. Left orchiectomy was performed, and histological diagnosis was seminoma. Serum tumor markers were normalized after 3rd-line chemotherapy, but lymph node metastases were still enlarged. Then the cervical lymph node was excised, and histologically diagnosed as mature teratoma. Based on these results, we diagnosed this case as growing teratoma syndrome. Since the whole metastasis was too large to be completely excised, we started systemic interferon alfa-2b (IntronR A) administration. The metastasis initially responded to the therapy by 20% reduction in size and remained stable thereafter. However, the mediastinal lesion caused obstructive pneumonia, which was bronchoscopically resected. At the time of 12 years after the initial presentation, the tumors are well controlled with stable disease or only modest increase.
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Uegaki
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Negoro
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Toshinari
authors.initials: T
authors.lastname: Yamasaki
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Segawa
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kamba
authors.affiliation: The Department of Urology, Kyoto University Graduate School of Medicine.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D009919:Orchiectomy; D013724:Teratoma / Q000188:drug therapy* / Q000601:surgery; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D016898:Interferon-alpha