title: Validation of the yale-brown obsessive compulsive scale modified for binge eating.
abstract: OBJECTIVE
  Establish the Yale-Brown obsessive compulsive scale modified for binge eating (YBOCS-BE) as a fit for purpose measure of treatment benefit in clinical trials of binge eating disorder (BED).
  
  
  METHODS
  YBOCS-BE psychometric properties were evaluated with data from a Phase 2 randomized controlled trial of lisdexamfetamine dimesylate in 260 adults with BED. Assessments included: Cohen's effect size estimates of item-level sensitivity and scale-level external responsiveness; item-to-total correlations; Cronbach's alpha for internal consistency reliability; Spearman correlations against reference measures for construct validity; known-groups analyses for discriminating ability; t tests of within-group differences between baseline and post baseline visits for internal responsiveness; and multiple anchor-based approaches to estimate minimum clinically important change (MCIC).
  
  
  RESULTS
  No significant distribution anomalies were seen. Items appear sensitive to treatment group differences. Item-to-total correlations were positive. Internal consistency is 0.81. Large correlations (>0.50) were seen between YBOCS-BE score change and the Clinical Global Impression-Improvement (CGI-I; 0.58) and score changes for the following; number of binge days (0.38), Clinical Global Impression-Severity (CGI-S; 0.57), the disinhibition (0.57) and hunger (0.52) subscales of the Three-Factor Eating Questionnaire (TFEQ), and the Barratt Impulsiveness Scale (BIS-11; 0.58). MCIC estimates range from -4 to -17.
  
  
  CONCLUSIONS
  The YBOCS-BE was found to be a reliable and valid measure of an important and unique concept in BED-related clinical studies. Study limitations include using protocol-defined BED severity level and the exclusion of psychiatric comorbidities.
authors.affiliation: Director, Shire Development, Inc.
authors.forename: Linda S
authors.initials: LS
authors.lastname: Deal
authors.affiliation: Vector Psychometric Group, LLC, Managing Partner.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wirth
authors.affiliation: Global Development Team Lead, Neuroscience, Shire Development, Inc.
authors.forename: Maria
authors.initials: M
authors.lastname: Gasior
authors.affiliation: Global Medical Lead, Neuroscience, Shire Development, Inc.
authors.forename: Barry K
authors.initials: BK
authors.lastname: Herman
authors.affiliation: Chief Research Officer, Lindner Center of HOPE, Professor of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine.
authors.forename: Susan L
authors.initials: SL
authors.lastname: McElroy
mesh_terms: D000293:Adolescent; D000328:Adult; D056912:Binge-Eating Disorder / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology* / Q000523:psychology; D011594:Psychometrics / Q000379:methods*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Yale-Brown obsessive compulsive scale; binge eating disorder; scale validation