title: Ultrashort Antimicrobial Peptides with Antiendotoxin Properties.
abstract: Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK.
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Ya-Han
authors.initials: YH
authors.lastname: Chih
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Yen-Shan
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan Department of Neurology, National Taiwan University Hospital, Hsinchu, Taiwan.
authors.forename: Bak-Sau
authors.initials: BS
authors.lastname: Yip
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hsiu-Ju
authors.initials: HJ
authors.lastname: Wei
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hung-Lun
authors.initials: HL
authors.lastname: Chu
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
authors.forename: Hsi-Tsung
authors.initials: HT
authors.lastname: Cheng
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan ytchou@life.nthu.edu.tw jwcheng@life.nthu.edu.tw.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chou
authors.affiliation: Institute of Biotechnology and Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan ytchou@life.nthu.edu.tw jwcheng@life.nthu.edu.tw.
authors.forename: Jya-Wei
authors.initials: JW
authors.lastname: Cheng
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D015091:beta-Alanine / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D008070:Lipopolysaccharides; D015091:beta-Alanine; C063914:beta-naphthylalanine