title: Correction of Hormonal and Metabolic Disorders in Male Rats with Developing Experimental Diabetes.
abstract: Synthetic radioinert androgen methyltrienolone administered daily for 2 weeks to male rats with severe diabetes led to a sharp increase in blood testosterone and was accompanied by reduction in glucose level due to an increase in tissue sensitivity to insulin. Normalization of plasma testosterone concentration contributed to saturation of active androgen receptors in the myocardium with testosterone; the number of free receptors decreased by 1.8 times. Testosterone that diminishes the catabolic effects of glucocorticoids improved the state of the myocardium, which was confirmed by activation of DNA and RNA synthesis.
authors.affiliation: I. A. Natishvili Institute of Experimental Morphology of I. Javakhishvili Tbilisi State University, Tbilisi, Georgia.
authors.forename: N A
authors.initials: NA
authors.lastname: Didebulidze
authors.forename: M Sh
authors.initials: MSh
authors.lastname: Kakabadze
authors.forename: N G
authors.initials: NG
authors.lastname: Gordadze
authors.forename: I N
authors.initials: IN
authors.lastname: Latsabidze
authors.forename: M E
authors.initials: ME
authors.lastname: Kordzaya
authors.forename: I T
authors.initials: IT
authors.lastname: Sikharulidze
mesh_terms: D045930:Anabolic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D004261:DNA Replication; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006321:Heart / Q000187:drug effects; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D015741:Metribolone / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009206:Myocardium / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism; D013739:Testosterone / Q000097:blood* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D045930:Anabolic Agents; D001786:Blood Glucose; D007328:Insulin; D011944:Receptors, Androgen; D015741:Metribolone; D013739:Testosterone; D004958:Estradiol; D012313:RNA; D013006:Growth Hormone; D003345:Corticosterone