title: Drug-induced liver injury from initial dose of infliximab.
abstract: Acute hepatotoxicity secondary to infliximab can occur with or without autoimmunity. A growing body of infliximab drug-induced liver injury cases without autoantibody formation is emerging. Nearly all other reported cases occur after at least three doses. This suggests infliximab may have a direct cytotoxic effect on the liver. We report a case of drug-induced liver injury resulting after an initial dose of infliximab.
authors.affiliation: Department of Gastroenterology, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889.
authors.forename: Fong-Kuei F
authors.initials: FK
authors.lastname: Cheng
authors.affiliation: Department of Internal Medicine, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Bridges
authors.affiliation: Department of Gastroenterology, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889.
authors.forename: John D
authors.initials: JD
authors.lastname: Betteridge
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D000069285:Infliximab / Q000009:adverse effects*; D008297:Male; D008889:Military Personnel; D014481:United States
chemical_list: D005765:Gastrointestinal Agents; D000069285:Infliximab