title: Review peptide-targeted liposomes for selective drug delivery: Advantages and problematic issues.
abstract: We describe the use of bioactive peptides to drive liposomal drugs on target receptors overexpressed in cancer cells. A detailed description for several targeting liposomes derivatized with different peptides and thus able to target relevant receptors for cancer therapy is reported. Even if the development of peptide-targeted liposomes represents a great advance in the use of liposomal drugs for cancer therapy, many critical issues are still unsolved in the development of these innovative drug delivery systems. Advantages and drawbacks of the peptide-mediated active targeting are discussed.
authors.affiliation: Department of Pharmacy, CIRPeB, University of Naples "Federico II" and Invectors srl, 80134, Napoli, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Accardo
authors.affiliation: Department of Pharmacy, CIRPeB, University of Naples "Federico II" and Invectors srl, 80134, Napoli, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Morelli
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism
chemical_list: D008081:Liposomes; D010455:Peptides; D018719:Erb-b2 Receptor Tyrosine Kinases
keywords: active targeting; bioactive peptides; liposomal drugs; pegylation; peptide-targeted liposomes