title: Palladium-catalyzed chemoselective synthesis of indane-1,3-dione derivatives via tert-butyl isocyanide insertion.
abstract: A simple and efficient strategy for the synthesis of indane-1,3-dione derivatives through a palladium(0)-catalyzed reaction incorporating tert-butyl isocyanide has been developed. In addition, by applying this protocol as the key step, indenopyrazole derivatives can be easily synthesized in high yields in a one-pot procedure. This methodology is tolerant of a wide range of substrates and applicable to library synthesis.
authors.affiliation: College of Pharmaceutical Science, Soochow University, 199 Ren-ai Road, Suzhou 215123, China. zhuyongming@suda.edu.cn yangshilin@suda.edu.cn.
authors.forename: Huaqing
authors.initials: H
authors.lastname: Duan
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Han
authors.forename: Yulin
authors.initials: Y
authors.lastname: Feng
authors.forename: Yongming
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D007189:Indans; D009570:Nitriles; D054852:Small Molecule Libraries; D010165:Palladium; C099535:tert-butyl isocyanide