title: HIV-negative Primary Bone Marrow Hodgkin Lymphoma Manifesting with a High Fever Associated with Hemophagocytosis as the Initial Symptom: A Case Report and Review of the Previous Literature.
abstract: A 68-year-old man was referred to our hospital due to a high fever and pancytopenia. Neither tumors nor infectious lesions were detected. Hemophagocytosis was observed on the bone marrow (BM) smear, although without abnormal cells. Prednisolone therapy was ineffective for the patient's high fever. Later on, we obtained the results of a BM biopsy indicating the presence of infiltration of atypical Reed-Sternberg cells, leading to a diagnosis of HIV-negative primary bone marrow Hodgkin lymphoma (PBMHL). However, the patient died of multiple organ failure before receiving chemotherapy. As the clinical course of PBMHL is rapid, physicians must keep in mind its possibility in similar cases.
authors.affiliation: Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Morita
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Emoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Serizawa
authors.forename: Shinya
authors.initials: S
authors.lastname: Rai
authors.forename: Chikara
authors.initials: C
authors.lastname: Hirase
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kanai
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shiga
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Junichi
authors.initials: J
authors.lastname: Miyatake
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tatsumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ashida
authors.forename: Masatomo
authors.initials: M
authors.lastname: Kimura
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ito
authors.forename: Itaru
authors.initials: I
authors.lastname: Matsumura
mesh_terms: D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D005334:Fever / Q000209:etiology*; D018023:HIV Seronegativity; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000473:pathology; D016539:Reed-Sternberg Cells / Q000473:pathology