title: First Report of OXA-181-Producing Escherichia coli in China and Characterization of the Isolate Using Whole-Genome Sequencing.
abstract: We report the first OXA-181-producing strain in China. blaOXA-181 was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. blaOXA-181 was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of blaOXA-181.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wu
authors.affiliation: Laboratory of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xinchuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D002681:China; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D004927:Escherichia coli Infections / Q000188:drug therapy*; D029968:Escherichia coli Proteins / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D047090:beta-Lactams; D001618:beta-Lactamases; C000607154:beta-lactamase OXA-181, E coli