title: Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation.
abstract: Nanoparticles based on poly(dimethylaminoethyl methacrylate)-b-poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p-DMAEMA-b-(DMAEMA-co-PAA-co-BMA)) were loaded with farnesol or apigenin for the controlled, pH-dependent release of the two agents to inhibit pathogenic bacteria-producing biofilms. The inventions are mainly directed against Streptococcus mutans, the oral cavity bacterium responsible for dental caries.
authors.affiliation: Università degli Studi di Firenze, Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche e Nutraceutiche , Via U. Schiff 6, I-50019 Sesto Fiorentino (Firenze) , Italy claudiu.supuran@unifi.it.
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000179:Acrylates / Q000737:chemistry; D047310:Apigenin / Q000008:administration & dosage* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects*; D003692:Delayed-Action Preparations; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control; D005204:Farnesol / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles; D010330:Patents as Topic; D011108:Polymers / Q000737:chemistry; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000179:Acrylates; D003692:Delayed-Action Preparations; D008689:Methacrylates; D011108:Polymers; C116863:poly(butyl methacrylate); C501628:poly(propyl acrylic acid); D005204:Farnesol; D047310:Apigenin; C049840:2-(dimethylamino)ethyl methacrylate
keywords: Streptococcus mutans; antibacterial agent; biofilm; nanoparticle; pH-dependent controlled release; poly(dimethylaminoethyl methacrylate