title: Domain-Focused CRISPR Screening Identifies Potential Drug Targets.
abstract: Targeting protein domain-encoding exons in CRISPR-Cas9 screens can reveal genetic dependencies.
mesh_terms: D000818:Animals; D064113:CRISPR-Cas Systems; D018390:Gene Targeting; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy / Q000662:veterinary; D051379:Mice; D058990:Molecular Targeted Therapy; D016297:Mutagenesis, Site-Directed; D017434:Protein Structure, Tertiary / Q000187:drug effects*; D000094704:RNA, Guide, CRISPR-Cas Systems / Q000378:metabolism
chemical_list: D000094704:RNA, Guide, CRISPR-Cas Systems