title: Vulvovaginal-gingival Lichen Planus: Association with Lichen Planopilaris and Stratified Epithelium-specific Antinuclear Antibodies.
abstract: Vulvovaginal-gingival lichen planus (VVG-LP) consists of a triad of symptoms: vulval, vaginal and gingival lichen planus lesions. The aim of this study was to analyse the prevalence of lesions in various anatomical locations in patients with VVG-LP. The study included 126 consecutive patients with lichen planus. Sixteen (12.7%) patients fulfilled the criteria of VVG-LP. In 12/16 (75%) patients with VVG-LP scalp lesions were also observed. Stratified epithelium-specific antinuclear antibodies (SES-ANA) and anti-ΔNp.3α antibodies were detected in 10/16 (75%) patients with VVG-LP and in 15/110 (13.6%) patients with other forms of lichen planus (p < 0.05). In conclusion, VVG-LP is frequently associated with lichen planopilaris. The new entity may be termed "vulvovaginal-gingival-pilar lichen planus" and our study indicates that SES-ANA is a marker of this type of lichen planus with extensive, severe and refractory-to-therapy involvement of the mucous membranes, skin and scalp.
authors.affiliation: Department of Dermatology, Medical University of Warsaw, Koszykowa 82a, PL-02008 Warsawa, Poland. malgorzata.olszewska@wum.edu.pl.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Olszewska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Banka-Wrona
authors.forename: Anna
authors.initials: A
authors.lastname: Skrok
authors.forename: Adriana
authors.initials: A
authors.lastname: Rakowska
authors.forename: Renata
authors.initials: R
authors.lastname: Górska
authors.forename: Lynn W
authors.initials: LW
authors.lastname: Solomon
authors.forename: Lidia
authors.initials: L
authors.lastname: Rudnicka
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005882:Gingival Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D017676:Lichen Planus, Oral / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D009626:Terminology as Topic; D014623:Vaginal Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D014845:Vulvar Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers