title: Proteomics, biomarkers, and HIV-1: A current perspective.
abstract: Despite more than three decades of extensive research, HIV-1 infection although well controlled with cART, remains incurable. Multifactorial complexity of the viral life-cycle poses great challenges in understanding molecular mechanisms underlying this infection and the development of biomarkers, which we hope will lead us to its eradication. For a more in-depth understanding of how the virus interacts with host target cells, T cells and macrophages, proteomic profiling techniques that offer strategies to investigate the proteome in its entirety were employed. Here, we review proteomic studies related to HIV-1 infection and discuss perspectives and limitations of proteomic and systems biology approaches in future studies.
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Maire Rose
authors.initials: MR
authors.lastname: Donnelly
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA.
authors.forename: Pawel
authors.initials: P
authors.lastname: Ciborowski
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D040901:Proteomics; D014764:Viral Proteins / Q000032:analysis* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D014764:Viral Proteins
keywords: Biomarker; Body fluids; HIV; Macrophage; Systems biology; T cell