title: Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma--a review.
abstract: Multiple trauma patients require extremely good management and thus, the trauma team needs to be prepared and to be up to date with the new standards of intensive therapy. Oxidative stress and free radicals represent an extremely aggressive factor to cells, having a direct consequence upon the severity of lung inflammation. Pulmonary tissue is damaged by oxidative stress, leading to biosynthesis of mediators that exacerbate inflammation modulators. The subsequent inflammation spreads throughout the body, leading most of the time to multiple organ dysfunction and death. In this paper, we briefly present an update of biochemical effects of oxidative stress and free radical damage to the pulmonary tissue in patients in critical condition in the intensive care unit. Also, we would like to present a series of active substances that substantially reduce the aggressiveness of free radicals, increasing the chances of survival.
authors.forename: Ovidiu Horea
authors.initials: OH
authors.lastname: Bedreag
authors.affiliation: Emergency County Hospital Timisoara, Clinic of Anesthesia and Intensive Care, Timisoara, Romania; "Victor Babes" University of Medicine and Pharmacy Timisoara, Faculty of Medicine, Timisoara, Romania; West University of Timisoara, Faculty of Chemistry, Biology, Geography, Timisoara, Romania. alexandru.rogobete@gmail.com.
authors.forename: Alexandru Florin
authors.initials: AF
authors.lastname: Rogobete
authors.forename: Mirela
authors.initials: M
authors.lastname: Sarandan
authors.forename: Alina Carmen
authors.initials: AC
authors.lastname: Cradigati
authors.forename: Marius
authors.initials: M
authors.lastname: Papurica
authors.forename: Maria Corina
authors.initials: MC
authors.lastname: Dumbuleu
authors.forename: Alexandru Mihai
authors.initials: AM
authors.lastname: Chira
authors.forename: Oana Maria
authors.initials: OM
authors.lastname: Rosu
authors.forename: Dorel
authors.initials: D
authors.lastname: Sandesc
mesh_terms: D055371:Acute Lung Injury / Q000503:physiopathology / Q000628:therapy*; D000975:Antioxidants / Q000627:therapeutic use*; D003422:Critical Care; D016638:Critical Illness; D006801:Humans; D009104:Multiple Trauma / Q000503:physiopathology / Q000628:therapy*; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants
keywords: antioxidant therapy; critically ill patient; inflammation; lung injury; multiple trauma; oxidative stress