title: [Genetic polymorphisms of 30 InDel loci in Chinese ethnic population residing in Tibet].
abstract: OBJECTIVE
  To analyze the genetic data of 30 insertion and deletion polymorphisms (InDel) loci included in an InvestigatorR DIPplex diagnostic kit, and to evaluate the forensic application in ethnic Tibetan population from China.
  
  
  METHODS
  By detecting 226 unrelated individuals with the Investigator(R) DIPplex kit, allelic frequencies and population genetics parameters of the 30 InDels were statistically analyzed and compared with available data derived from other populations from various regions.
  
  
  RESULTS
  After the Bonferroni correction at a 95% significance level (P=0.0017), no significant departures from the Hardy-Weinberg equilibrium were observed except for the HLD114 locus. Linkage disequilibrium test showed no significant allelic association between all 30 loci after the Bonferroni's correction. The average heterozygosity (Ho) of all loci was 0.4125, the mean discrimination power (DP) was 0.5618, the mean polymorphism information content (PIC) was 0.3280, and the combined discrimination power (TDP) was 0.999999999990. The combined power of exclusion of all loci was 0.987 849 91 in trio cases and 0.94977125 in duo cases. Genetic distance between Tibetan and Han from Beijing was minimum (0.0068) in the 5 populations, while genetic distance between Tibetan and Uygur was maximal (0.0215).
  
  
  CONCLUSIONS
  Multiplex detection has revealed that these 30 InDel loci have a moderate distribution of genetic polymorphism among ethnic Tibetan group residing in Tibet, China.
authors.affiliation: Collaborative Innovation Center of Judicial Civilization, Beijing 100088, P.R.China. shimeisen2000@163.com.
authors.forename: Rufeng
authors.initials: R
authors.lastname: Bai
authors.forename: Yaju
authors.initials: Y
authors.lastname: Liu
authors.forename: Lizhe
authors.initials: L
authors.lastname: Jiang
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Lyv
authors.forename: Meisen
authors.initials: M
authors.lastname: Shi
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D054643:INDEL Mutation; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018609:Tibet / Q000208:ethnology; D055815:Young Adult