title: The impact of perioperative allogeneic blood transfusion on survival in elderly patients with colorectal cancer.
abstract: BACKGROUND
  The relationship between perioperative allogeneic blood transfusion (ABT) and survival following curative surgery for colorectal cancer (CRC) in elderly patients has not been elucidated to date.
  
  
  METHODS
  The cases of 108 patients aged 75 years or more who underwent curative surgery for CRC between 2004 and 2011 were retrospectively reviewed. The association between perioperative ABT requirements and other clinicopathological variables was examined. Subsequently, perioperative ABT was compared with other variables concerning overall survival (OS) by univariate and multivariate analyses.
  
  
  RESULTS
  Tumor depth, lymph node metastasis and hemoglobin levels were significantly associated with perioperative ABT. Transfused patients had significantly worse OS compared to non-transfused patients. In the multivariate analysis, perioperative ABT (hazard ratio=3.16, 95% confidence interval=1.11-8.98, p=0.031) was the only independent indicator of OS.
  
  
  CONCLUSIONS
  Perioperative ABT was significantly associated with increased mortality in elderly patients with CRC.
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan m.kaneko@fancy.ocn.ne.jp.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kaneko
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Sasaki
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishimaru
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Terai
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakayama
authors.affiliation: Department of Surgery, Omori Red Cross Hospital, Ota-ku, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D019990:Perioperative Care; D011379:Prognosis; D016019:Survival Analysis; D065227:Transfusion Reaction
keywords: Blood transfusion; TRIM; colorectal cancer; immunosenescence