title: Antimalarial Effect of 3-Methoxy-1,2-Dioxetanes on the Erythrocytic Cycle of Plasmodium falciparum.
abstract: The antimalarial activity of peroxides most likely originates from their interaction with iron(II) species located inside the malaria parasite, which forms destructive radical species through a Fenton-like mechanism. This article reports the first evaluation of the in vitro antimalarial activity of three peroxides of the class 1,2-dioxetanes against Plasmodium falciparum; the results reveal that the studied 3-methoxy-1,2-dioxetanes display significant antimalarial activity, at a similar level as artemisinin and also that their reactivity toward iron(II) correlate linearly with their antimalarial activity.
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP, 09210-580, Brazil.
authors.forename: Nicolas S
authors.initials: NS
authors.lastname: Lopes
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP, 09210-580, Brazil.
authors.forename: Ariane M
authors.initials: AM
authors.lastname: Yoshitake
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP, 09210-580, Brazil.
authors.forename: Adriana F
authors.initials: AF
authors.lastname: Silva
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP, 09210-580, Brazil.
authors.forename: Vani X
authors.initials: VX
authors.lastname: Oliveira
authors.affiliation: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, RJ 21944-970, Brazil.
authors.forename: Leandro S
authors.initials: LS
authors.lastname: Silva
authors.affiliation: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Rio de Janeiro, RJ 21944-970, Brazil.
authors.forename: Ana A S
authors.initials: AA
authors.lastname: Pinheiro
authors.affiliation: Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, Santo André, SP, 09210-580, Brazil.
authors.forename: Luiz Francisco M L
authors.initials: LF
authors.lastname: Ciscato
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D010545:Peroxides; C031327:artemisinin
keywords: 1,2-dioxetanes; Fenton reaction; Plasmodium falciparum; antimalarial peroxides