title: Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review.
abstract: Dendritic cells (DCs) either boost the immune system (enhancing immunity) or dampen it (leading to tolerance). This dual effect explains their vital role in cancer development and progression. DCs have been tested as a predictor of outcomes for cancer progression. Eight studies evaluated tumour-infiltrating DCs (TIDCs) as a predictor for colorectal cancer (CRC) outcomes. The detection of TIDCs has not kept pace with the increased knowledge about the identification of DC subsets and their maturation status. For that reason, it is difficult to draw a conclusion about the performance of DCs as a predictor of outcome for CRC. In this review, we comprehensively examine the evidence for the in situ immune response due to DC infiltration, in predicting outcome in primary CRC and how such information may be incorporated into routine clinical assessment.
authors.affiliation: a Antigen Presentation Research Group, Imperial College London, North West London Hospitals Campus , Harrow, Middlesex , UK.|b Department of Surgery St Marks Hospital , Harrow, Middlesex , UK.
authors.forename: George
authors.initials: G
authors.lastname: Malietzis
authors.affiliation: a Antigen Presentation Research Group, Imperial College London, North West London Hospitals Campus , Harrow, Middlesex , UK.|b Department of Surgery St Marks Hospital , Harrow, Middlesex , UK.
authors.forename: Gui H
authors.initials: GH
authors.lastname: Lee
authors.affiliation: b Department of Surgery St Marks Hospital , Harrow, Middlesex , UK.
authors.forename: John T
authors.initials: JT
authors.lastname: Jenkins
authors.affiliation: a Antigen Presentation Research Group, Imperial College London, North West London Hospitals Campus , Harrow, Middlesex , UK.
authors.forename: David
authors.initials: D
authors.lastname: Bernardo
authors.affiliation: c Department of Histopathology St Marks Hospital , Harrow, Middlesex , UK.
authors.forename: Morgan
authors.initials: M
authors.lastname: Moorghen
authors.affiliation: a Antigen Presentation Research Group, Imperial College London, North West London Hospitals Campus , Harrow, Middlesex , UK.
authors.forename: Stella C
authors.initials: SC
authors.lastname: Knight
authors.affiliation: a Antigen Presentation Research Group, Imperial College London, North West London Hospitals Campus , Harrow, Middlesex , UK.
authors.forename: Hafid O
authors.initials: HO
authors.lastname: Al-Hassi
mesh_terms: D019013:CD40 Antigens / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D016208:Databases, Factual; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D011379:Prognosis; D015996:Survival Rate
chemical_list: D019013:CD40 Antigens
keywords: colorectal cancer; outcomes; tumour-infiltrating dendritic cells