title: Composite silica coated gold nanosphere and quantum dots nanoparticles for X-ray CT and fluorescence bimodal imaging.
abstract: In this study, silica coated Au nanospheres (Au@SiO2) were prepared by a reverse microemulsion method; subsequently, a layer of fluorescent quantum dots (QDs) were adsorbed onto it and then it was coated with silica again. After modifying with PVP, the composite silica coated gold nanosphere and quantum dots nanoparticle (Au@SiO2-QDs/SiO2-PVP) was obtained. This composite structure contained Au and QDs, and it could be used for contrast-enhanced X-ray CT imaging and fluorescence imaging. Characterization showed that the composite nanoparticle had good dispersity, a high fluorescence intensity and a good effect of X-ray absorption, and it was suitable for using as a bimodal imaging probe.
authors.affiliation: Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China. zydi@mail.hust.edu.cn.
authors.forename: Ji-Tao
authors.initials: JT
authors.lastname: Song
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Yang
authors.forename: Xiao-Shuai
authors.initials: XS
authors.lastname: Zhang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Yan
authors.forename: Ming-Hao
authors.initials: MH
authors.lastname: Yao
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Qin
authors.forename: Yuan-Di
authors.initials: YD
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity; D003974:Diatrizoate Meglumine / Q000737:chemistry / Q000633:toxicity; D004655:Emulsions; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000633:toxicity; D006046:Gold / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D061848:Optical Imaging; D011205:Povidone / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry* / Q000633:toxicity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000633:toxicity; D017550:Spectroscopy, Fourier Transform Infrared; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004655:Emulsions; D005456:Fluorescent Dyes; D003974:Diatrizoate Meglumine; D006046:Gold; D012822:Silicon Dioxide; D011205:Povidone