title: N-Heterocyclic Carbene-Catalyzed Oxidative Annulations of α,β-Unsaturated Aldehydes with Hydrazones: Selective Synthesis of Optically Active 4,5-Dihydropyridazin-3-ones and Pyridazin-3-ones.
abstract: A novel and efficient method for the highly enantioselective synthesis of chiral 4,5-dihydropyridazin-3-one derivatives has been developed based on the chiral N-heterocyclic carbene-catalyzed oxidative annulation between α,β-unsaturated aldehydes and hydrazones. Meanwhile, the selective synthesis of either 4,5-dihydropyridazin-3-ones or pyridazin-3-one derivatives from the same reactants has been achieved by simply varying catalytic and reaction conditions.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Mao
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Zi-Tian
authors.initials: ZT
authors.lastname: Wang
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Zhan-Yong
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006835:Hydrazones; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C573777:4,5-dihydropyridazin-3-one; D000447:Aldehydes; D006571:Heterocyclic Compounds; D006835:Hydrazones; D011724:Pyridazines; C030011:carbene; D008697:Methane