title: [Reversible posterior encephalopathy syndrome and cardiomyopathy after bevacizumab therapy].
abstract: BACKGROUND
  Bevacizumab is an antibody directed against VEGF-A. It is approved for the treatment of many cancer diseases. Its side effects are currently not well known by physicians.
  
  
  METHODS
  A 70-year-old female with metastatic colonic adenocarcinoma was admitted in the intensive care unit because of a coma, four days after having received a combined monthly chemotherapy containing bevacizumab, oxaliplatine, 5 fluorouracil, and folinic acid for the fourth time. On clinical examination, she presented with lower limbs spasticity and hypertension. Etiologic investigations, including cerebral tomodensitometry, cerebrospinal fluid examination, psychotropic drugs urinary testing, and electroencephalogram, were negative. Consciousness improved without any other treatment than nicardipine and urapidil, but the patient was initially confused. Cerebral magnetic resonance imaging showed changes suggestive of posterior reversible encephalopathy syndrome, but also involving frontal lobes. There were additional biological and echocardiographic changes suggestive of cardiac involvement. The patient recovered completely of both cardiac and neurologic manifestations 10 days later.
  
  
  CONCLUSIONS
  Physicians should be aware of cardiovascular adverse effects of bevacizumab. High blood pressure must be treated to avoid more severe complications. When a posterior reversible encephalopathy syndrome occurs, cardiac involvement should be investigated.
authors.affiliation: Service de médecine interne NHC, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
authors.forename: L
authors.initials: L
authors.lastname: Frantzen
authors.affiliation: Service de médecine interne NHC, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address: murielle.rondeau@chru-strasbourg.fr.
authors.forename: M
authors.initials: M
authors.lastname: Rondeau-Lutz
authors.affiliation: Service de médecine interne NHC, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Mosquera
authors.affiliation: Service de médecine interne NHC, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France; Faculté de médecine de Strasbourg, université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Martinez
authors.affiliation: Service de radiologie, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France; Faculté de médecine de Strasbourg, université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Labani
authors.affiliation: Service de médecine interne NHC, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France; Faculté de médecine de Strasbourg, université de Strasbourg, 4, rue Kirschleger, 67085 Strasbourg cedex, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Weber
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000068258:Bevacizumab / Q000009:adverse effects* / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000139:chemically induced*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced*
chemical_list: D000068258:Bevacizumab
keywords: Bevacizumab; Bévacizumab; Cardiac disease; Cardiopathie; Posterior reversible encephalopathy syndrome; Syndrome d’encéphalopathie postérieure réversible