title: Supramolecular hydrophobic guest transport system based on pillar[5]arene.
abstract: A pillar[5]arene-based bioactive guest loading system has been developed, which can increase the solubility of the drug norharmane in aqueous medium, and also enable its pH-stimulated release. Furthermore, this supramolecular transport system reduces the toxicity of loaded guest.
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. s.dong@schalley-lab.de c.schalley@fu-berlin.de.
authors.forename: Zhenhui
authors.initials: Z
authors.lastname: Qi
authors.forename: Katharina
authors.initials: K
authors.lastname: Achazi
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
authors.forename: Shengyi
authors.initials: S
authors.lastname: Dong
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Schalley
mesh_terms: D002243:Carbolines / Q000737:chemistry* / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D047028:Macrocyclic Compounds / Q000737:chemistry*; D009000:Monocytes; D066244:Proton Magnetic Resonance Spectroscopy; D012995:Solubility; D013050:Spectrometry, Fluorescence
chemical_list: D002243:Carbolines; D004337:Drug Carriers; D047028:Macrocyclic Compounds; C010262:norharman