title: To study the efficacy and safety of doxophylline and theophylline in bronchial asthma.
abstract: BACKGROUND
  Asthma is a non communicable chronic disease prevalent all over the world. Two commonly used methylxanthines, theophylline and doxofylline were compared in the study in stable asthmatic patients at recommended doses by various spirometric lung function tests with forced expiratory volume at second one (FEVI) between 50 to 80% of predicted FEVI.
  
  
  METHODS
  A total of 100 patients were divided in two groups. Group I was administered 300 mg theophylline twice a day and Group II was administered doxofylline 400 mg twice a day orally for six weeks. Spirometric variables symptom score, and adverse effects were recorded at the baseline level and after six weeks of therapy. Data was compared and analysed statistically.
  
  
  RESULTS
  The spirometric values of forced expiratory volume in 1 second (FEVI), forced vital capacity (FVC), and FEV1/FVC showed a statistically significant improvement over base line with the use of both theophylline as well as doxophylline, but were not statistically different from each other. There was a statistically significant improvement in peak expiratory flow rate (PEFR) after six weeks of treatment with doxophylline compared to theophylline. It was found that the doxophylline has a better safety profile as compared to theophylline. Adverse events occurred in a greater proportion of patients in the theophylline group.
  
  
  CONCLUSIONS
  In the study it was concluded that both theophylline and doxofylline improved the lung function tests and symptoms in patients of mild Bronchial Asthma, but doxofylline has a better profile in terms of safety.
authors.affiliation: Assistant Professor, Department of Pharmacology, Maharishi Markandeshwar Medical College and Hospital , Kumarhatti, Solan, (H.P), India .
authors.forename: Sami Manzoor
authors.initials: SM
authors.lastname: Margay
authors.affiliation: Associate Professor, Department of Pharmacology, GMC , Srinagar, India .
authors.forename: Samina
authors.initials: S
authors.lastname: Farhat
authors.affiliation: Associate Professor, Department of Pharmacology, Maharishi Markandeshwar Medical College and Hospital , Kumarhatti, Solan, (H.P), India .
authors.forename: Sharanjit
authors.initials: S
authors.lastname: Kaur
authors.affiliation: Assistant Professor, Department of Medicine, Maharishi Markandeshwar Medical College and Hospital , Kumarhatti, Solan, (H.P), India .
authors.forename: Hilal Ahmad
authors.initials: HA
authors.lastname: Teli
keywords: Lung function tests; Methylxanthines; Moderate asthma