title: The TP53 Codon 72 Polymorphism and Risk of Sporadic Prostate Cancer among Iranian Patients.
abstract: BACKGROUND
  The TP53 gene is one of the most frequently mutated genes amongst human malignancies, particularly TP53 codon 72 polymorphism. Furthermore, an association between the TP53 codon 72 variants and prostate cancer has been reported in several studies. Although some studies have indicated an association between the TP53 Arg/Arg variant and an increased risk for prostate cancer, other studies have shown a positive correlation between the TP53 Pro/Pro genotype instead. Therefore, to clarify if this polymorphism is associated with an increased risk of prostate cancer in Iranian men, we conducted a case-control study of 40 sporadic prostate cancer patients and 80 benign prostate hyperplasia cases.
  
  
  METHODS
  The TP53 codon 72 was genotyped using an allele specific PCR.
  
  
  RESULTS
  A significant association between the TP53 codon 72 genotype and prostate cancer risk was found (OR = 6.8, 95% CI = [1.8-25.1], P = 0.005). However, the results of this study did not support an association between age, the Gleason score nor TP53 genotype at codon 72 in prostate cancer patients.
  
  
  CONCLUSIONS
  TP53 codon 72 polymorphism may have a great impact in the development of prostate cancer.
authors.affiliation: 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Babaei
authors.affiliation: 2. School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Ahmadi
authors.affiliation: 3. Dept. of Microbiology, School of Medicine, Kermanshah University of Medical Sciences , Kermanshah, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Abiri
authors.affiliation: 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Farhad
authors.initials: F
authors.lastname: Rezaei
authors.affiliation: 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Naseri
authors.affiliation: 4. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mahmoudi
authors.affiliation: 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Rakhshande
authors.initials: R
authors.lastname: Nategh
authors.affiliation: 1. Dept. of Virology, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Talat
authors.initials: T
authors.lastname: Mokhtari Azad
keywords: Benign prostate hyperplasia; Sporadic prostate cancer; TP53 codon 72 polymorphism