title: Structural Biology of Bacterial Type IV Secretion Systems.
abstract: Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein-DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu in which bacteria live. This review describes the various biochemical and structural advances made toward understanding the biogenesis, architecture, and function of T4SSs.
authors.affiliation: Section of Structural Biology, Department of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.
authors.forename: Vidya
authors.initials: V
authors.lastname: Chandran Darbari
authors.forename: Gabriel
authors.initials: G
authors.lastname: Waksman
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D005144:F Factor / Q000235:genetics; D008854:Microscopy, Electron; D000069319:Type IV Secretion Systems / Q000737:chemistry* / Q000648:ultrastructure*
chemical_list: D000069319:Type IV Secretion Systems
keywords: bacterial pathogenesis; conjugation; effector secretion; pilus biogenesis; type IV secretion system