title: Circulating irisin detection: Does it really work?
abstract: The recent discovery of irisin has generated considerable interest in the scientific community. However, many studies on the biochemistry and biology of this intriguing hormone yielded controversial results in humans, which were mostly attributable to a number of drawbacks in the methods used for its detection and measurement.
authors.affiliation: Research Institute of Hospital 12 de Octubre ('i+12'), Avda. de Córdoba s/n, 28041 Madrid, Spain. Electronic address: fabian.sanchis@uv.es.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Research Institute "Dr. Viña Giner", Molecular and Mitochondrial Medicine, School of Medicine, Catholic University of Valencia San Vicente Mártir, Valencia, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Alis
authors.affiliation: Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
mesh_terms: D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: ELISA kit; FNDC5; antibodies; exercise; irisin; mass spectrometry