title: [Antiapoptotic effect of gangliosides on PC12 cells exposed to bacterial lipopolysaccharide].
abstract: Lipopolysaccharide (LPS) from Escherichia coli of the 0111:B4 serotype was shown to exert the apoptotic effect on PC12 neuronal cells at concentrations of 0.1 and 0.125 mg/ml in DMEM (serum free medium). GD1a and GM1 gangliosides at a concentration of 100 μM were found to raise the PC12 cell viability and decrease the percentage of PC12 cells in the late apoptotic phase after exposure to LPS.
authors.forename: L V
authors.initials: LV
authors.lastname: Bayunova
authors.forename: G G
authors.initials: GG
authors.lastname: Parnova
authors.forename: N F
authors.initials: NF
authors.lastname: Avrova
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D005732:Gangliosides / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats
chemical_list: D005732:Gangliosides; D008070:Lipopolysaccharides; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside