title: Determination of the chemical structures of tandyukisins B-D, isolated from a marine sponge-derived fungus.
abstract: Tandyukisins B-D (1-3), novel decalin derivatives, have been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and their structures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, their chemical structures were established by chemical transformation. They exhibited weak cytotoxicity, but selective growth inhibition on panel screening using 39 human cancer cell lines.
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. yamada@gly.oups.ac.jp.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. j.apricot_woods-0621@docomo.ne.jp.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Umebayashi
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. when-you.with-upon.a-star@disney.ne.jp.
authors.forename: Maiko
authors.initials: M
authors.lastname: Kawashima
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. ye9m13bxwt2kkbzpyxyf@docomo.ne.jp.
authors.forename: Yuma
authors.initials: Y
authors.lastname: Sugiura
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. t.kikuchi@gly.oups.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kikuchi
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan. tanakar@gly.oups.ac.jp.
authors.forename: Reiko
authors.initials: R
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D009281:Naphthalenes; C007229:decalin
keywords: Halichondria okadai; Trichoderma harzianum; cytotoxicity; decalin; marine microorganism