title: In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes.
abstract: Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
authors.affiliation: Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investigação de Parasitologia Médica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal Centro de Malária e Outras Doenças Tropicais, IHMT, UNL, Lisbon, Portugal scortes@ihmt.unl.pt mcristi@ualg.pt.
authors.forename: Sofia
authors.initials: S
authors.lastname: Cortes
authors.affiliation: Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investigação de Parasitologia Médica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal.
authors.forename: Andreia
authors.initials: A
authors.lastname: Albuquerque
authors.affiliation: Centro de Ciências do Mar (CCMAR), Universidade do Algarve (UAlg), Campus de Gambelas, Faro, Portugal Departamento de Química e Farmácia, UAlg, Campus de Gambelas, Faro, Portugal.
authors.forename: Lília I L
authors.initials: LI
authors.lastname: Cabral
authors.affiliation: Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investigação de Parasitologia Médica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal Departamento Ciências Biomédicas e Medicina, UAlg, Campus de Gambelas, Faro, Portugal.
authors.forename: Liliana
authors.initials: L
authors.lastname: Lopes
authors.affiliation: Global Health and Tropical Medicine (GHTM), Unidade de Ensino e Investigação de Parasitologia Médica, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Lisbon, Portugal Departamento de Química e Farmácia, UAlg, Campus de Gambelas, Faro, Portugal Departamento Ciências Biomédicas e Medicina, UAlg, Campus de Gambelas, Faro, Portugal.
authors.forename: Lenea
authors.initials: L
authors.lastname: Campino
authors.affiliation: Centro de Ciências do Mar (CCMAR), Universidade do Algarve (UAlg), Campus de Gambelas, Faro, Portugal Departamento de Química e Farmácia, UAlg, Campus de Gambelas, Faro, Portugal scortes@ihmt.unl.pt mcristi@ualg.pt.
authors.forename: Maria L S
authors.initials: ML
authors.lastname: Cristiano
mesh_terms: D000977:Antiparasitic Agents / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D018432:Drug Resistance, Multiple; D006573:Heterocyclic Compounds, 1-Ring / Q000494:pharmacology*; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy*; D008264:Macrophages / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D013141:Spiro Compounds / Q000494:pharmacology*
chemical_list: D000977:Antiparasitic Agents; D037621:Artemisinins; D006573:Heterocyclic Compounds, 1-Ring; D013141:Spiro Compounds