title: Facile Fabrication of Near-Infrared-Resonant and Magnetic Resonance Imaging-Capable Nanomediators for Photothermal Therapy.
abstract: Although many techniques exist for fabricating near-infrared (NIR)-resonant and magnetic resonance imaging (MRI)-capable nanomediators for photothermal cancer therapy, preparing them in an efficient and scalable process remains a significant challenge. In this report, we exploit one-step siloxane chemistry to facilely conjugate NIR-absorbing satellites onto a well-developed polysiloxane-containing polymer-coated iron oxide nanoparticle (IONP) core to generate dual functional core-satellite nanomediators for photothermal therapy. An advantage of this nanocomposite design is the variety of potential satellites that can be simply attached to impart NIR resonance, which we demonstrate using NIR-resonant gold sulfide nanoparticles (Au2SNPs) and the NIR dye IR820 as two example satellites. The core-satellite nanomediators are fully characterized by using absorption spectra, dynamic light scattering, ζ potential measurements, and transmission electron microscopy. The enhanced photothermal effect under the irradiation of NIR laser light is identified through in vitro solutions and in vivo mice studies. The MRI capabilities as contrast agents are demonstrated in mice. Our data suggest that polysiloxane-containing polymer-coated IONPs can be used as a versatile platform to build such dual functional nanomediators for translatable, MRI-guided photothermal cancer therapy.
authors.affiliation: ‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Chen
authors.affiliation: †Key Laboratory of Smart Drug Deliver, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Rd., Shanghai 201203, People's Republic of China.|‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Ren
authors.affiliation: ‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Hayley J
authors.initials: HJ
authors.lastname: Paholak
authors.affiliation: ‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Burnett
authors.affiliation: ‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.|§Fujian Health College, Fuzhou, Fujian 350101, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ni
authors.affiliation: †Key Laboratory of Smart Drug Deliver, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Rd., Shanghai 201203, People's Republic of China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Fang
authors.affiliation: ‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109, United States.
authors.forename: Duxin
authors.initials: D
authors.lastname: Sun
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D012833:Siloxanes / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013499:Surface Properties; D000068936:Theranostic Nanomedicine / Q000379:methods*; D023041:Xenograft Model Antitumor Assays
chemical_list: D012833:Siloxanes
keywords: MRI; copolymer; nanocomposite; photothermal therapy; siloxane; surface modification