title: Highly sensitive determination of reduced glutathione based on a cobalt nanoparticle implanted-modified indium tin oxide electrode.
abstract: Cobalt nanoparticle modified indium tin oxide (CoNP/ITO) electrodes fabricated by ion implantation were applied for the detection of reduced glutathione (GSH). The CoNP/ITO electrode was characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) detector and X-ray photoelectron spectroscopy (XPS). The assay performance with regard to GSH were evaluated by cyclic voltammetry (CV) and chronoamperometry (I-t). The proposed sensor exhibited a much higher electrocatalytic activity toward the oxidation of GSH than the bare ITO electrode, with a detection limit of 5 nM. The CoNP/ITO electrode showed enhanced electrocatalytic properties, high sensitivity, good long-term stability and reproducibility as well as a rapid response to detect GSH. In addition, the CoNP/ITO electrode was also used to analyse the GSH concentration in eye drop samples, and the results were in good agreement with the labelled values.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing 100875, PR China. hujingbo@bnu.edu.cn.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Su
authors.forename: Zhengjun
authors.initials: Z
authors.lastname: Xiao
authors.forename: Shuang
authors.initials: S
authors.lastname: Hao
authors.forename: Yuanchun
authors.initials: Y
authors.lastname: Li
authors.forename: Jingbo
authors.initials: J
authors.lastname: Hu
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D005978:Glutathione / Q000032:analysis*; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D056951:Photoelectron Spectroscopy; D015203:Reproducibility of Results; D017971:Tin Compounds / Q000737:chemistry*
chemical_list: D017971:Tin Compounds; D003035:Cobalt; C109984:indium tin oxide; D005978:Glutathione