title: Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries.
abstract: OBJECTIVE
  Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury.
  
  
  METHODS
  A total of 74 rats were divided into six groups, namely the control, the trauma, the normal saline, a 25mg/kg EGCG, a 50mg/kg EGCG and a daily consumption group (10mg/kg EGCG was given intraperitoneally for 14 days before the trauma). Except the first group, the other groups underwent a 1-minute sciatic nerve compression by clip with 50gr/cm2 pressure. Nerve samples were obtained at 28 day after trauma for the biochemical and histopathological analysis.
  
  
  RESULTS
  Our study showed that the Daily consumption, 25mg/kg EGCG and 50mg/kg EGCG groups demonstrated statistically significant decreased lipid peroxidation levels and particularly daily consumption, and the 25mg/kg EGCG group showed a favourable reduction of degeneration and edema histologically.
  
  
  CONCLUSIONS
  This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury.
authors.affiliation: Ankara Numune Research and Education Hospital, Department of Neurosurgery, Ankara, Turkey.
authors.forename: Ali Erdem
authors.initials: AE
authors.lastname: Yildirim
authors.forename: Ali
authors.initials: A
authors.lastname: Dalgic
authors.forename: Denizhan
authors.initials: D
authors.lastname: Divanlioglu
authors.forename: Rifat
authors.initials: R
authors.lastname: Akdag
authors.forename: Nuri Eralp
authors.initials: NE
authors.lastname: Cetinalp
authors.forename: Fatih
authors.initials: F
authors.lastname: Alagoz
authors.forename: Fatma
authors.initials: F
authors.lastname: Helvacioglu
authors.forename: Gulnur
authors.initials: G
authors.lastname: Take
authors.forename: Yahya
authors.initials: Y
authors.lastname: Guvenc
authors.forename: Ismet
authors.initials: I
authors.lastname: Koksal
authors.forename: Ahmed Deniz
authors.initials: AD
authors.lastname: Belen
mesh_terms: D000818:Animals; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D059348:Peripheral Nerve Injuries / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018696:Neuroprotective Agents; D002392:Catechin; C045651:epigallocatechin gallate