title: Persistent Legionnaire's disease in an adult with hairy cell leukemia successfully treated with prolonged levofloxacin therapy.
abstract: Legionnaire's disease (LD) manifests most commonly as an atypical community acquired pneumonia (CAP) with systemic extrapulmonary manifestations. Disorders associated with impaired cell mediated immunity (CMI) are particularly predisposed to LD. Hairy cell leukemia (HCL) is a rare B-cell lymphoproliferative leukemia associated with decreased CMI. LD has only rarely been reported in HCL. We present a most interesting case of persistent LD in a elderly male with HCL who required prolonged antibiotic therapy.
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA. Electronic address: bacunha@winthrop.org.
authors.forename: Burke A
authors.initials: BA
authors.lastname: Cunha
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA.
authors.forename: Sigridh
authors.initials: S
authors.lastname: Munoz-Gomez
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Gran
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Raza
authors.affiliation: Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA; State University of New York, School of Medicine, Stony Brook, NY, USA.
authors.forename: Nadia
authors.initials: N
authors.lastname: Irshad
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D017714:Community-Acquired Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007877:Legionnaires' Disease / Q000150:complications*; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000188:drug therapy*; D064704:Levofloxacin / Q000627:therapeutic use*; D008297:Male; D018410:Pneumonia, Bacterial / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin
keywords: Clinical diagnosis of Legionnaire's disease; Legionnaire's disease atypical pneumonia; Legionnaire's disease in compromised hosts; Legionnaire's disease therapy; Oral antibiotic therapy