title: Macronutrients and caloric intake in health and longevity.
abstract: Both lifespan and healthspan are influenced by nutrition, with nutritional interventions proving to be robust across a wide range of species. However, the relationship between nutrition, health and aging is still not fully understood. Caloric restriction is the most studied dietary intervention known to extend life in many organisms, but recently the balance of macronutrients has been shown to play a critical role. In this review, we discuss the current understanding regarding the impact of calories and macronutrient balance in mammalian health and longevity, and highlight the key nutrient-sensing pathways that mediate the effects of nutrition on health and ageing.
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia samantha.solon-biet@sydney.edu.au.
authors.forename: Samantha M
authors.initials: SM
authors.lastname: Solon-Biet
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Mitchell
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Raubenheimer
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
authors.forename: David G
authors.initials: DG
authors.lastname: Le Couteur
authors.affiliation: Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia Charles Perkins CentreBuilding D17, University of Sydney, Sydney, New South Wales 2006, AustraliaANZAC Research Institute and the Ageing and Alzheimers InstituteCentre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, AustraliaSchool of Biological SciencesUniversity of Sydney, Sydney, New South Wales, AustraliaTranslational Gerontology BranchNational Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USAFaculty of Veterinary ScienceUniversity of Sydney, Sydney, New South Wales, Australia.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Simpson
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000375:Aging / Q000502:physiology; D000818:Animals; D031204:Caloric Restriction; D018753:Diet, Protein-Restricted; D002149:Energy Intake / Q000502:physiology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005502:Food; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008136:Longevity / Q000502:physiology*; D009747:Nutritional Physiological Phenomena; D056564:Sirtuin 1 / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D007328:Insulin; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D007334:Insulin-Like Growth Factor I; D058570:TOR Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D056564:Sirtuin 1
keywords: calories; health; lifespan; longevity; macronutrients