title: A new 9,11-secosterol with a 1,4-quinone from a Korean marine sponge Ircinia sp.
abstract: An intensive investigation of chemical components for Ircinia sp. led to the isolation of a new 9,11-secosterol. The chemical structure of this compound was elucidated based on the interpretation of NMR and MS spectroscopic data. The isolated compound exhibited antibacterial activities against Staphylococcus epidermidis and Bacillus subtilis with MIC values of 6.3 and 25 μg ml(-1), respectively.
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Korea.
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.affiliation: College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Korea.
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Chemistry and Nano Science, Global Top5 Program, Ewha Womans University, Seoul, 120-750, Korea. sjnam@ewha.ac.kr.
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Korea. hjkang@snu.ac.kr.|Research Institute of Oceanography, Seoul National University, NS-80, Seoul, 151-747, Korea. hjkang@snu.ac.kr.
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D056910:Republic of Korea; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011809:Quinones; D012632:Secosteroids
keywords: Antibacterial; Ircinia; Marine natural product; Secosterol; Sponge