title: A case of intravascular lymphoma diagnosed in an explanted liver after liver transplantation.
abstract: Intravascular lymphoma (IVL) is a rare form of B-cell lymphoma. We encountered a rare case of IVL diagnosed in an explanted liver. A 49-year-old man visited a clinic with high fever. Because of elevated liver function, he was diagnosed with acute liver failure. Deceased donor liver transplantation (LT) was performed 16 days after admission. The post-transplantation course was uneventful until IVL was reported in the explanted liver on postoperative day (POD) 21. Rituximab was administered on POD 27, and rituximab-cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone (R-CHOP) treatment administered on POD 38. The R-CHOP treatment was repeated for eight cycles, and the patient remains free of recurrence 1 year post-transplantation. Although systemic lymphoma is a contraindication to transplantation, our experience indicates that IVL can be successfully treated by the administration of prompt chemotherapy after LT for fulminant hepatitis.
authors.affiliation: Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Kobe University, Kobe, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Kuramitsu
authors.affiliation: Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Kobe University, Kobe, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University, Kobe, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yano
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kobe University, Kobe, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Hirano
authors.affiliation: Division of Anesthesiology, Department of Surgery Related, Kobe University, Kobe, Japan.
authors.forename: Takuyo
authors.initials: T
authors.lastname: Misumi
authors.affiliation: Department of Hematology, Kobe University, Kobe, Japan.
authors.forename: Yosio
authors.initials: Y
authors.lastname: Katayama
authors.affiliation: Department of Hematology, Kobe University, Kobe, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawano
authors.affiliation: Division of Medical Oncology/Hematology, Department of Medicine, Kobe University, Kobe, Japan.
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Yakushijin
authors.affiliation: Department of Diagnostic Pathology, Kobe University, Kobe, Japan.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Zen
authors.affiliation: Department of Diagnostic Pathology, Kobe University, Kobe, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Itoh
authors.affiliation: Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, Kobe University, Kobe, Japan.
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
mesh_terms: D000208:Acute Disease; D018951:Antigens, CD20 / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001808:Blood Vessels / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005704:Gallbladder / Q000098:blood supply; D006391:Hemangioma / Q000150:complications; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D033162:Incidental Findings; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D017093:Liver Failure / Q000209:etiology* / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications; D016031:Liver Transplantation; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000188:drug therapy; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D012141:Respiratory Tract Infections / Q000150:complications; D000069283:Rituximab / Q000008:administration & dosage; D013156:Splenectomy; D019737:Transplants / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D018951:Antigens, CD20; D000951:Antigens, Neoplasm; D007166:Immunosuppressive Agents; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: deceased donors; liver clinical, outcome