title: Intraperitoneal Administration of Muramyl Dipeptide β-Heptylglycoside to Pregnant and Non-Pregnant Female Mice Modulates Production of Th1/Th2/Th17/Tr1 Cytokines by Splenocytes Ex Vivo.
abstract: Muramyl dipeptide β-heptylglycoside (C7MDP) was administered to non-pregnant CBA female mice and pregnant mice after non-abortion-prone mating (CBA×BALB/c) and mating associated with a high rate of spontaneous abortion (CBA×DBA/2). In non-pregnant females, C7MDP increased the production of IL-2, IL-4, IL-5, IL-6, IL-17, IFNγ, TNFα, and GM-CSF at constant production of IL-1α and IL-10. C7MDP increased the production of IL-10 and IL-17 and suppressed the production of IFNγ on day 8 of gestation in non-abortion-prone mouse couples and stimulated the synthesis of IL-4 and IFNγ, reduced IL-5 production, and slightly increased IL-1α secretion after abortion-prone mating. On day 14 of gestation, C7MDP elevated the yield of IL-2, IL-4, IFNγ, TNFα, and GM-CSF in CBA×BALB/c and CBA×DBA/2 couples and IL-17 in the fi rst variant of mating.
authors.affiliation: Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University, Ministry of Health, Russian Federation, Moscow, Russia, kalyuzhin@list.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Kalyuzhin
authors.forename: K A
authors.initials: KA
authors.lastname: Artem'eva
authors.forename: M N
authors.initials: MN
authors.lastname: Boltovskaya
authors.forename: K A
authors.initials: KA
authors.lastname: Bunyatyan
authors.forename: E V
authors.initials: EV
authors.lastname: Inviyayeva
authors.forename: L I
authors.initials: LI
authors.lastname: Vinnitskii
authors.forename: A V
authors.initials: AV
authors.lastname: Karaulov
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D003433:Crosses, Genetic; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D004195:Disease Models, Animal; D020964:Embryo Loss / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D005260:Female; D006020:Glycopeptides / Q000008:administration & dosage / Q000633:toxicity*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000235:genetics; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D007378:Interleukins / Q000096:biosynthesis / Q000235:genetics; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011247:Pregnancy; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D006020:Glycopeptides; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; C403942:heptylglycoside-muramyldipeptide; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor