title: In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis.
abstract: We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
authors.affiliation: Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain.
authors.forename: Débora Nunes
authors.initials: DN
authors.lastname: Mario
authors.affiliation: Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
authors.affiliation: Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Janio Morais
authors.initials: JM
authors.lastname: Santurio
authors.affiliation: Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
authors.forename: Sydney Hartz
authors.initials: SH
authors.lastname: Alves
authors.affiliation: Microbiology Unit, Medical School, Universitat Rovira i Virgili, IISPV, Reus, Spain javier.capilla@urv.cat.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D026141:Drug Resistance, Multiple, Fungal; D004359:Drug Therapy, Combination; D051379:Mice; D008826:Microbial Sensitivity Tests; D013175:Sporothrix / Q000187:drug effects* / Q000472:pathogenicity; D013174:Sporotrichosis / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B