title: Diagnostic Utility of the International HIV Dementia Scale for HIV-Associated Neurocognitive Impairment and Disorder in South Africa.
abstract: Studies in sub-Saharan Africa indicate that most HIV seropositive persons have HIV-associated neurocognitive disorder (HAND). HAND diagnosis is facilitated by specific screening. Seventy participants were recruited from an HIV voluntary counseling and testing clinic in Durban, South Africa. The diagnostic utility of the International HIV Dementia Scale (IHDS) was analyzed using a receiver operating characteristic (ROC) model. The ROC analysis comparing any HAND diagnosis (based on two neuropsychological tests) versus no diagnosis was statistically significant, with an optimal cut-off score of 10.5, sensitivity of 69%, and specificity of 74%. Sensitivity of the IHDS was highest for HIV-associated dementia.
authors.affiliation: From the Dept. of Mental Health, AIDS Healthcare Foundation, Los Angeles, CA (KG); Dept. of Psychiatry and Behavioral Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN (KG); Dept. of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (EL, DJH); Dept. of Psychology, Loyola Marymount University, Los Angeles, CA (DJH); Dept. of Psychiatry, McCord Hospital, Durban, South Africa (DS); and Dept. of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (EL).
authors.forename: Karl
authors.initials: K
authors.lastname: Goodkin
authors.affiliation: From the Dept. of Mental Health, AIDS Healthcare Foundation, Los Angeles, CA (KG); Dept. of Psychiatry and Behavioral Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN (KG); Dept. of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (EL, DJH); Dept. of Psychology, Loyola Marymount University, Los Angeles, CA (DJH); Dept. of Psychiatry, McCord Hospital, Durban, South Africa (DS); and Dept. of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (EL).
authors.forename: David J
authors.initials: DJ
authors.lastname: Hardy
authors.affiliation: From the Dept. of Mental Health, AIDS Healthcare Foundation, Los Angeles, CA (KG); Dept. of Psychiatry and Behavioral Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN (KG); Dept. of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (EL, DJH); Dept. of Psychology, Loyola Marymount University, Los Angeles, CA (DJH); Dept. of Psychiatry, McCord Hospital, Durban, South Africa (DS); and Dept. of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (EL).
authors.forename: Dinesh
authors.initials: D
authors.lastname: Singh
authors.affiliation: From the Dept. of Mental Health, AIDS Healthcare Foundation, Los Angeles, CA (KG); Dept. of Psychiatry and Behavioral Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN (KG); Dept. of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA (EL, DJH); Dept. of Psychology, Loyola Marymount University, Los Angeles, CA (DJH); Dept. of Psychiatry, McCord Hospital, Durban, South Africa (DS); and Dept. of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (EL).
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D015704:CD4 Antigens; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D013019:South Africa / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015704:CD4 Antigens