title: The effect of MRI contrast agents on hepatic and splenic uptake in the rabbit during (99m) Tc-MDP bone scintigraphy.
abstract: The objective of this study was to investigate the effects of Omniscan® and Magnevist® on (99m) Tc-MDP uptake in rabbits during (99m) Tc-MDP bone scintigraphy. In Experiment Group 1, 30 healthy adult rabbits were randomized into six subgroups (n = 5); each subgroup experienced a different time interval between injections (30 min, 60 min, 120 min, 240 min, 360 min, 24 h). All six subgroups were injected first with Omniscan®, then with (99m) Tc-MDP. After 7 days, the same six subgroups were injected with normal saline followed by (99m) Tc-MDP at the same time intervals. In Experiment Group 2, 20 healthy adult rabbits were allocated randomly to four subgroups (n = 5); each subgroup experienced a different time interval between injections (30 min, 60 min, 120 min, 240 min). All four subgroups were injected first with Magnevist®, then with (99m) Tc-MDP. After 7 days, the same four subgroups were injected with normal saline followed by (99m) Tc-MDP. In all experiments, whole-body skeletal imaging was performed. Liver, spleen, and background were delineated to determine the target-to-background (T/B) ratio. Diffusely increased intake of the imaging agent was seen in the liver and spleen when the injection-time interval between Omniscan® and (99m) Tc-MDP varied from 30 min to 240 min and when the time interval between Magnevist® and (99m) Tc-MDP was 30 min-60 min. The imaging findings are consistent with the results of L/B and S/B ratios in each experiment group. Both Omniscan® and Magnevist® have an effect on (99m) Tc-MDP uptake during bone scanning; the main effect is diffusely increased hepatic and splenic activity.
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Zhanwen
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wan
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, 646000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D001692:Biological Transport; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D019786:Gadolinium DTPA / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000378:metabolism; D013154:Spleen / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019786:Gadolinium DTPA; D013669:Technetium Tc 99m Medronate
keywords: 99mTc-MDP; Magnevist®; Omniscan®; liver; spleen; whole-body imaging