title: Talc Pleurodesis With Intense 18F-FDG Activity But No 68Ga-DOTA-TATE Activity on PET/CT.
abstract: Talc pleurodesis (TP) is a technique, widely employed in the management of patients with persistent pleural effusions or pneumothoraces not amenable to other treatment options. It is well documented that talc deposits produce areas of highly increased F-FDG uptake, because of talc-induced inflammation. We present a case of a patient with history of TP who was evaluated with both F-FDG and Ga-DOTA-TATE. The hypermetabolic area seen on F-FDG-PET-CT in the region of talc placement showed no uptake by Ga-DOTA-TATE, suggesting the potential role of Ga-DOTA-TATE-PET-CT in elucidating F-FDG-postitive lesions in patients with history of both neuroendocrine malignancy and TP.
authors.affiliation: From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center; †Division of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health; ‡Center for Research in Computer Vision, University of Central Florida, Orlando, FL; and §Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD.
authors.forename: Georgios Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Corina
authors.initials: C
authors.lastname: Millo
authors.forename: Ulas
authors.initials: U
authors.lastname: Bagci
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Patronas
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D009942:Organometallic Compounds; D010996:Pleural Effusion / Q000000981:diagnostic imaging* / Q000628:therapy; D018700:Pleurodesis; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013627:Talc / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013627:Talc; C513399:gallium Ga 68 dotatate