title: Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility.
abstract: Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10-22, odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.22-1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10-53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.
authors.affiliation: The First Hospital of Harbin, Harbin 150070, Heilongjiang, China. mengyao0451@163.com.
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Chen
authors.affiliation: The Department of Internal Circulation, the Second People's Hospital of Mudanjiang, Mudanjiang 157013, Heilongjiang, China. hailepan0451@163.com.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Fu
authors.affiliation: Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, Heilongjiang, China. guangyuwanghrb@163.com.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.affiliation: Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. liuguiyou1981@163.com.
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China. xiupingbaihrb@163.com.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Bai
mesh_terms: D044466:Asian People / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
keywords: meta-analysis; myocardial infarction; rs10757278