title: Physical inactivity and risk of poor quality of life among elderly cancer survivors compared to women without cancer: the Iowa Women's Health Study.
abstract: OBJECTIVE
  Few studies have examined lifestyle factors and quality of life (QOL) in cancer survivors compared to a cancer-free group. Compared to active cancer-free women, we examined the association between physical inactivity and QOL in elderly cancer survivors and similar-aged women without cancer.
  
  
  METHODS
  Participants included 1776 cancer survivors and 12,599 cancer-free women enrolled in the Iowa Women's Health Study in 1986 who completed the SF36 QOL assessment in 2004 (ages 73-88 years). The odds of poor QOL were computed for each SF36 subscale (>0.5 SD below mean score of cancer-free women) associated with physical inactivity (moderate-vigorous activity <once/week) between four groups based on the cross-classification of cancer history (no/yes) and physical inactivity (no/yes) (referent group = active cancer-free women).
  
  
  RESULTS
  Compared with the referent group, inactive cancer survivors were significantly more likely to report poor QOL for each SF36 subscale (odds ratios 1.8 to 4.7), independent of age, comorbidity, body mass index (BMI), and diet quality. The greatest odds for poor QOL occurred for general health, vitality, and physical function. These increased odds occurred regardless of whether survivors were inactive at both baseline (1986) and follow-up or became inactive sometime after baseline. Among physically active women, cancer survivors had similar QOL as cancer-free women.
  
  
  CONCLUSIONS
  These findings provide evidence on the importance of leisure-time physical activity in older women and support the need for interventions to help older women maintain or regain a physically active lifestyle.
  
  
  CONCLUSIONS
  Survivors who remain or become physically active as they age report better mental and physical QOL.
authors.affiliation: Division of Epidemiology & Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN, 55454, USA. blair016@umn.edu.
authors.forename: Cindy K
authors.initials: CK
authors.lastname: Blair
authors.affiliation: Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
authors.forename: Kim
authors.initials: K
authors.lastname: Robien
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institute on Minority Health and Health Disparities, Washington, DC, USA.
authors.forename: Maki
authors.initials: M
authors.lastname: Inoue-Choi
authors.affiliation: Department of Political Science, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Wendy
authors.initials: W
authors.lastname: Rahn
authors.affiliation: Division of Epidemiology & Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN, 55454, USA.|Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
authors.forename: DeAnn
authors.initials: D
authors.lastname: Lazovich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D004032:Diet; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008019:Life Style; D009043:Motor Activity / Q000502:physiology*; D011788:Quality of Life; D057185:Sedentary Behavior; D017741:Survivors / Q000706:statistics & numerical data*; D016387:Women's Health
keywords: Cancer survivors; Cohort; Physical activity; Quality of life; Survivorship