title: Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata.
abstract: Bioassay-guided fractionation of an EtOH extract of the roots of the plant Apoplanesia paniculata (Fabaceae) led to the isolation of the three known compounds amorphaquinone (1), pendulone (2), and melilotocarpan C (3), and the two new pterocarpans 4 and 5. Compounds 1 and 2 exhibited good antiplasmodial activity with IC50 values of 5.7 ± 1.5 and 7.0 ± 0.8 µM, respectively. Compound 3 exhibited weak antiplasmodial activity (41.8 ± 5.2 µM), while compounds 4 and 5 were inactive. Compound 6 was synthesized to confirm the structure of 5, and it showed enhanced antiplasmodial activity (15.8 ± 1.4 µM) compared to its analogues 3-5.
authors.affiliation: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
authors.forename: Qingxi
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
authors.forename: Priscilla
authors.initials: P
authors.lastname: Krai
authors.affiliation: Natural Products Discovery Institute, Doylestown, Pennsylvania, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Goetz
authors.affiliation: Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
authors.forename: Maria B
authors.initials: MB
authors.lastname: Cassera
authors.affiliation: Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia, United States.
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*; D036343:Pterocarpans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D007529:Isoflavones; D010936:Plant Extracts; D036343:Pterocarpans; D011809:Quinones; C569897:amorphaquinone; C569898:pendulone