title: Total anti-oxidant capacity of saliva in chronic periodontitis patients before and after periodontal treatment.
abstract: BACKGROUND
  Periodontal disease is among the most common inflammatory conditions which is associated with many different factors. One of the contributing factors to the pathogenesis of this condition may compromise the defensive mechanism of antioxidants. The present study evaluates the antioxidant capacity of saliva in periodontal patients before and after periodontal treatment.
  
  
  METHODS
  In this cross sectional study, 31 patients systemically healthy non smokers with chronic periodontitis were recruited. The antioxidant capacity of saliva was measured before the initial phase of periodontal therapy and after completion of the treatment. Data were analyzed using SPSS 19 software. Paired T-Test, Independent sample T-test and ANOVA tests were used as appropriated.
  
  
  RESULTS
  The mean and standard deviation antioxidant capacity of the saliva after the treatment.(0.962± 0.287µM)was significantly higher than before the treatment (0.655 ± 0.281 µM ,p<0.001). The mean difference of antioxidant capacity of the saliva before and after periodontal treatment was higher among men than among women; however, the difference was not significant (P=0.07). The mean difference of salivary antioxidant capacity was not significantly differed among different ages (P=0.772).
  
  
  CONCLUSIONS
  The antioxidant capacity of saliva was higher after periodontal therapy among patients with periodontal disease, however the change was not varied across the ages and gender. Therefore, the alterations in the defensive mechanism of antioxidants could be the key factors contribute to the pathogenesis of periodontal diseases.
authors.affiliation: Depatmnent of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Shirzaiy
authors.affiliation: Department of Periodontology, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: S M
authors.initials: SM
authors.lastname: Ansari
authors.affiliation: Department of Community Medicine, School of Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: J H
authors.initials: JH
authors.lastname: Dehghan
authors.affiliation: Depatmnent of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: S H
authors.initials: SH
authors.lastname: Ghaeni
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D055113:Chronic Periodontitis / Q000378:metabolism* / Q000601:surgery / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010517:Periodontics; D012463:Saliva / Q000737:chemistry*
chemical_list: D000975:Antioxidants
keywords: antioxidants; periodontitis; saliva.