title: Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones.
abstract: The modulation of the chromatin organization of eukaryotic cells plays an important role in regulating key cellular processes including host defence mechanisms against pathogens. Thus, to successfully survive in a host cell, a sophisticated bacterial strategy is the subversion of nuclear processes of the eukaryotic cell. Indeed, the number of bacterial proteins that target host chromatin to remodel the host epigenetic machinery is expanding. Some of the identified bacterial effectors that target the chromatin machinery are 'eukaryotic-like' proteins as they mimic eukaryotic histone writers in carrying the same enzymatic activities. The best-studied examples are the SET domain proteins that methylate histones to change the chromatin landscape. In this review, we will discuss SET domain proteins identified in the Legionella, Chlamydia and Bacillus genomes that encode enzymatic activities targeting host histones. Moreover, we discuss their possible origin as having evolved from prokaryotic ancestors or having been acquired from their eukaryotic hosts during their co-evolution. The characterization of such bacterial effectors as modifiers of the host chromatin landscape is an exciting field of research as it elucidates new bacterial strategies to not only manipulate host functions through histone modifications but it may also identify new modifications of the mammalian host cells not known before.
authors.affiliation: Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.|CNRS UMR 3525, Paris, France.
authors.forename: Monica
authors.initials: M
authors.lastname: Rolando
authors.affiliation: Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.|CNRS UMR 3525, Paris, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Gomez-Valero
authors.affiliation: Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.|CNRS UMR 3525, Paris, France.
authors.forename: Carmen
authors.initials: C
authors.lastname: Buchrieser
mesh_terms: D001407:Bacillus / Q000502:physiology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D001426:Bacterial Proteins / Q000378:metabolism*; D002689:Chlamydia / Q000502:physiology; D002843:Chromatin / Q000378:metabolism; D044127:Epigenesis, Genetic; D006657:Histones / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D007875:Legionella / Q000502:physiology; D008745:Methylation; D011496:Protein Methyltransferases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D001426:Bacterial Proteins; D002843:Chromatin; D006657:Histones; D011496:Protein Methyltransferases