title: [The dynamics of feed-forward loop depends on regulator type in indirect pathway].
abstract: Gene networks contain a recurring motif, called the feed-forward loop, in which a transcription factor regulates target expression directly and indirectly via the second regulator. Here we present the results of mathematical modeling of feed-forward loops with either the transcription factor or miRNA as a repressor in the indirect pathway. We showed that the substitution of the transcription factor with miRNA changes the dynamic behavior of the feed-forward loop and lends new properties critical for biological system functioning.
authors.forename: M A
authors.initials: MA
authors.lastname: Duk
authors.forename: A M
authors.initials: AM
authors.lastname: Samsonov
authors.forename: M G
authors.initials: MG
authors.lastname: Samsonova
mesh_terms: D055592:Biophysical Phenomena; D025461:Feedback, Physiological; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D018390:Gene Targeting; D035683:MicroRNAs / Q000737:chemistry*; D008962:Models, Theoretical; D059372:Nucleotide Motifs; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors