title: Effects of a high-protein/low-carbohydrate versus a standard hypocaloric diet on adipocytokine levels and cardiovascular risk factors during 9 months, role of rs6923761 gene variant of glucagon-like peptide 1 receptor.
abstract: BACKGROUND
  The role of GLP-1 R variants on body weight response after dietary intervention is unclear.
  
  
  OBJECTIVE
  The aim was to investigate the role of this polymorphism on cardiovascular risk factors, adipokine levels and weight loss secondary to a high-protein/low-carbohydrate vs. standard hypocaloric diets during 9 months.
  
  
  METHODS
  211 obese subjects were randomly allocated to one of these two diets for a period of 9 months; diet HP (high protein/low carbohydrate) and diet S (standard).
  
  
  RESULTS
  Ninety-four patients (44.5%) had the genotype GG (wild group) and 117 (55.5%) patients had the next genotypes; GA (89 patients, 42.2%) or AA (28 patients, 13.3%) (mutant group). With both diets and in both genotype groups, body mass index, weight, fat mass, waist circumference and systolic blood pressure decreased. Anthropometric parameters were higher in non-A allele carriers than A allele carriers. With diet HP in both genotypes, LDL cholesterol, total cholesterol, leptin, insulin levels and HOMA-R decreased. With the diet S and only in wild genotype, the same parameters decreased, too.
  
  
  CONCLUSIONS
  Our data showed a lack of association of rs6923761 GLP-1 R polymorphism with weight loss. Better anthropometric parameters in obese subjects with the mutant allele (A) of rs6923761 GLP-1 R polymorphism were observed. Total cholesterol, LDL cholesterol, insulin levels and HOMA-R decreased in all patients with both diets, although A allele carriers treated with standard diet did not show these changes.
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain. dadluis@yahoo.es.
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain.
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Nutrition, Hospital Clinico Universitario, University of Valladolid, C/Los Perales 16, 47130, Simancas, Valladolid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Romero
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000178:diet therapy / Q000235:genetics; D050528:Diet, Carbohydrate-Restricted / Q000379:methods; D004038:Diet, Reducing / Q000379:methods*; D005260:Female; D005838:Genotype; D000067757:Glucagon-Like Peptide-1 Receptor / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss / Q000235:genetics / Q000502:physiology
chemical_list: D054392:Adipokines; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor
keywords: Glucagon-like peptide 1 receptor; Hypocaloric diet; Weight loss; rs6923761