title: The effect of simvastatin on relapse of tooth movement and bone mineral density in rats measured by a new method using microtomography.
abstract: OBJECTIVE
  To evaluate the effect of simvastatin on relapse of tooth movement in rats using microtomography (micro CT), as well as the correlation of bone density with the orthodontic relapse.
  
  
  METHODS
  Twenty-five adult male Wistar rats, divided into two groups, had stainless steel springs installed on left maxillary first molar. The molars were moved for 18 days, and after removing the springs, were applied by oral gavage, 5mg/kg of simvastatin in the experimental group for 20 days. Tooth relapse was assessed with a micro CT scanner, and the images chosen through the Data Viewer software 1.5.0.0 had their measurement guides made and checked by the software Image ProR plus 5.1, and compared by Mann-Whitney test. After rats were sacrificed, bone mineral density was evaluated by micro CT through the software CT Analyzer 1.13 and compared by independent T-test, as well as by Spearman correlation test.
  
  
  RESULTS
  Relapse and bone mineral density (BMD) was lower in the experimental group than in the control group, however without a statistically significant difference.
  
  
  CONCLUSIONS
  Simvastatin did not inhibit the relapse of tooth movement in rats, and there was no correlation between bone density and orthodontic relapse.
authors.affiliation: Department of Pathology, Federal University of Brasilia, Brazil.
authors.forename: Giovanni Modesto
authors.initials: GM
authors.lastname: Vieira
authors.affiliation: Department of Genetics and Morphology, UnB, Brasilia, DF, Brazil.
authors.forename: Sacha Braun
authors.initials: SB
authors.lastname: Chaves
authors.affiliation: UnB, Brasilia, DF, Brazil.
authors.forename: Vânia Maria Moraes
authors.initials: VM
authors.lastname: Ferreira
authors.affiliation: Uninga University, Bauru, SP, Brazil.
authors.forename: Karina Maria Salvatore de
authors.initials: KM
authors.lastname: Freitas
authors.affiliation: UnB, Brasilia, DF, Brazil.
authors.forename: Rivadávio Fernandes Batista
authors.initials: RF
authors.lastname: Amorim
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects; D001862:Bone Resorption / Q000517:prevention & control; D003720:Densitometry; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008437:Maxilla / Q000187:drug effects / Q000503:physiopathology; D017208:Rats, Wistar; D012008:Recurrence; D015203:Reproducibility of Results; D055502:Secondary Prevention / Q000379:methods*; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors; D014085:Tooth Migration / Q000000981:diagnostic imaging / Q000517:prevention & control*; D014087:Tooth Movement Techniques; D014092:Tooth Root / Q000187:drug effects / Q000503:physiopathology; D016896:Treatment Outcome; D055114:X-Ray Microtomography / Q000379:methods*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin