title: Rotavirus VP6 preparations as a non-replicating vaccine candidates.
abstract: Rotavirus (RV) structural proteins VP4 and VP7, located on the surface of viral particles, elicit neutralizing antibodies (Abs) and are therefore considered to be important components of RV vaccines. However, despite inducing neutralizing Abs, limits of cross-neutralizing activity and lack of full correlation with protection limit the usefulness of these proteins as protective agents against RV disease. VP6 protein, which forms the middle layer of RV particles, is discussed as an alternative vaccine candidate since it can induce cross-protective immune responses against different RV strains although the Ab raised is not neutralizing. This report reviews different functions of VP6 that can lead to considering it as an alternative vaccine against RV disease.
authors.affiliation: Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Jalilvand
authors.affiliation: Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sayed Mahdi
authors.initials: SM
authors.lastname: Marashi
authors.affiliation: Virology Department, Pasteur Institute of Iran, Tehran, Iran. Electronic address: z_shoja@pasteur.ac.ir.
authors.forename: Zabihollah
authors.initials: Z
authors.lastname: Shoja
mesh_terms: D000956:Antigens, Viral / Q000276:immunology* / Q000302:isolation & purification*; D036022:Capsid Proteins / Q000276:immunology* / Q000302:isolation & purification*; D056738:Cross Protection; D006801:Humans; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology* / Q000302:isolation & purification*
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D022243:Rotavirus Vaccines; C061332:VP6 protein, Rotavirus
keywords: Neutralizing; Protection; Rotavirus (RV); VP6