title: Effects of Interaction Between Dopamine D2 Receptor and Monoamine Oxidase A Genes on Smoking Status in Young Men.
abstract: Although the effect of gene-gene interaction on nicotine-dopamine metabolism for smoking behavior has been reported, polymorphisms of dopamine D2 receptor (DRD2) and monoamine oxidase A (MAOA) have not been simultaneously examined among smokers. In this study, 481 young Taiwanese men completed a self-report questionnaire on smoking status, and data were obtained on polymorphisms of DRD2 rs1800497, DRD2 rs1079597, MAOA rs309850, and MAOA rs1137070, urinary nicotine, and urinary cotinine. In a comparison of 261 current smokers and 220 never smokers, odds ratios (ORs) for the development of smoking in all genotypes were not statistically significant. Among smokers with DRD2 rs1079597 GG//MAOA rs309850 3-repeat, the OR of heavier smoking was 2.67 times higher (95% confidence interval [CI]: [1.08, 6.59], p = .031) and the score on the Fagerstrom test for nicotine dependence was higher (4.26 vs. 2.83) than in those with DRD2 rs1079597 AA//MAOA rs309850 3-repeat. Adjusted urinary cotinine concentration was significantly different between those two groups (median value: 95.83 ng/μl vs. 133.24 ng/μl, respectively, p = .045). These findings suggest that the interaction of DRD2 rs1079597 and MAOA rs309850 3-repeat affects smoking intensity in young Taiwanese men.
authors.affiliation: Department of Nursing, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Chih-Ling
authors.initials: CL
authors.lastname: Huang
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
authors.forename: Wei-Chih
authors.initials: WC
authors.lastname: Ou
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
authors.forename: Pei-Lain
authors.initials: PL
authors.lastname: Chen
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
authors.forename: Chen-Nu
authors.initials: CN
authors.lastname: Liu
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
authors.forename: Mei-Chih
authors.initials: MC
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, Erhlin Christian Hospital, Changhua Christian Medical Foundation, Erhlin, Taiwan.
authors.forename: Chia-Chen
authors.initials: CC
authors.lastname: Lu
authors.affiliation: Administration Center of Research and Education, Changhua Christian Hospital, Changhua Christian Medical Foundation, Changhua, Taiwan.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Administration Center of Research and Education, Changhua Christian Hospital, Changhua Christian Medical Foundation, Changhua, Taiwan.
authors.forename: Min-Hsuan
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Administration Center of Research and Education, Changhua Christian Hospital, Changhua Christian Medical Foundation, Changhua, Taiwan ching.shan.h@gmail.com.
authors.forename: Ching-Shan
authors.initials: CS
authors.lastname: Huang
mesh_terms: D000328:Adult; D005838:Genotype; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000235:genetics*; D011795:Surveys and Questionnaires; D013624:Taiwan
chemical_list: D017448:Receptors, Dopamine D2; D008995:Monoamine Oxidase
keywords: dopamine D2 receptor; monoamine oxidase A; smoking intensity