title: MicroRNAs in liver malignancies. Basic science applied in surgery.
abstract: Liver malignancies represent one of the major public health problems worldwide because of late diagnosis and failure of current treatments to offer a curative option for many of the patients. MicroRNAs (miRs) are small non-coding RNA molecules that are known to regulate the gene expression at a post-transcriptional level through complementary base pairing with thousands of messenger (m)RNAs. Recent data has shown the involvement of miRs in the pathogenesis of many human cancers, including those of the liver, with huge possible impact in the clinic, mainly due to the identification of non-coding RNAs as biomarkers that can often be detected in the systemic circulation. In the current review, we present the importance of miRs in liver cancers by discussing their role in the pathobiology of these diseases, apart from their role as diagnostic and prognostic markers for liver malignancies.
authors.affiliation: Department of Surgery, Ion Chiricuta Oncology Institute, Cluj Napoca, Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Muresan
authors.forename: Florin
authors.initials: F
authors.lastname: Zaharie
authors.forename: Anca
authors.initials: A
authors.lastname: Bojan
authors.forename: Ioana
authors.initials: I
authors.lastname: Frinc
authors.forename: Delia
authors.initials: D
authors.lastname: Dima
authors.forename: Sonia
authors.initials: S
authors.lastname: Selicean
authors.forename: Grigore-Aristide
authors.initials: GA
authors.lastname: Gafencu
authors.forename: Bobe
authors.initials: B
authors.lastname: Petrushev
authors.forename: Roxana
authors.initials: R
authors.lastname: Cojocneanu-Petric
authors.forename: Cristian
authors.initials: C
authors.lastname: Tefas
authors.forename: Andreea
authors.initials: A
authors.lastname: Cioca
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
authors.forename: Cristian
authors.initials: C
authors.lastname: Berce
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan-Neagoe
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.forename: Patriciu
authors.initials: P
authors.lastname: Achimas-Cadariu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary / Q000628:therapy; D035683:MicroRNAs / Q000097:blood / Q000502:physiology*; D059467:Transcriptome
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs