title: Abnormal regional homogeneity and its correlations with personality in first-episode, treatment-naive somatization disorder.
abstract: BACKGROUND
  Structural and functional abnormalities of the default mode network (DMN) and their correlations with personality have been found in somatization disorder (SD). However, no study is conducted to identify regional neural activity and its correlations with personality in SD. In this study, regional homogeneity (ReHo) was applied to explore whether abnormal regional neural activity is present in patients with SD and its correlations with personality measured by Eysenck Personality Questionnaire (EPQ).
  
  
  METHODS
  Twenty-five first-episode, treatment-naive patients with SD and 28 sex-, age-, and education-matched healthy controls participated in the whole study. During the scanning, all subjects were instructed to lie still with their eyes closed and remain awake. A ReHo approach was employed to analyze the data.
  
  
  RESULTS
  The SD group had a significantly increased ReHo in the left angular gyrus (AG) compared to healthy controls. The increased ReHo positively correlated to the neuroticism scores of EPQ (EPQ-N). No other correlations were detected between the ReHo values and other related factors, such as symptom severity and education level.
  
  
  CONCLUSIONS
  Our results suggest that abnormal regional neural activity of the DMN may play a key role in SD with clinical implications and emphasize the importance of the DMN in the pathophysiological process of SD.
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Qinji
authors.initials: Q
authors.lastname: Su
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Radiology, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000209:etiology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D000075384:Neuroticism; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000503:physiopathology*; D010551:Personality; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D013001:Somatoform Disorders / Q000150:complications* / Q000473:pathology*; D013223:Statistics as Topic
chemical_list: D010100:Oxygen
keywords: Functional magnetic resonance imaging; Personality; Regional homogeneity; Somatization disorder