title: Synthesising gene clock with toggle switch and oscillator.
abstract: The usefulness of a genetic clock lies in its role to stimulate a sequence of logic reactions for sequential biological circuits. A clock signal is a periodic square wave, its amplitude alternates at a steady frequency between fixed minimal and maximal levels. Transition between the minimum and the maximum is instantaneous for an ideal square wave; however, the function is unrealisable in physical bio-systems. This research develops a new genetic clock generator based on a genetic oscillator, in which, a sine wave generator is adopted as a signal oscillator. It is shown that combination of a genetic oscillator with a toggle switch is able to generate clock signals forming an efficient way to generate a near square wave. In silico study confirms the proposed idea.
authors.affiliation: Department of Electrical Engineering, National Chung Hsing University, Taichung 402, Taiwan. chunlin@dragon.nchu.edu.tw.
authors.forename: Chun-Liang
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Department of Electrical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
authors.forename: Po-Kuei
authors.initials: PK
authors.lastname: Chen
authors.affiliation: Department of Electrical Engineering, National Chung Hsing University, Taichung 402, Taiwan.
authors.forename: Young-Yi
authors.initials: YY
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics*; D003198:Computer Simulation; D005786:Gene Expression Regulation / Q000235:genetics*; D005812:Genes, Switch / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D015533:Transcriptional Activation / Q000235:genetics*