title: Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database.
abstract: Haemoptysis is a serious symptom with various aetiologies. Our aim was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income country.This retrospective multicentre study was based on the French nationwide hospital medical information database collected over 5 years (2008-2012). We analysed haemoptysis incidence, aetiologies, geographical and seasonal distribution and mortality. We studied recurrence, association with lung cancer and mortality in a 3-year follow-up analysis.Each year, ~15 000 adult patients (mean age 62 years, male/female ratio 2/1) were admitted for haemoptysis or had haemoptysis as a complication of their hospital stay, representing 0.2% of all hospitalised patients. Haemoptysis was cryptogenic in 50% of cases. The main aetiologies were respiratory infections (22%), lung cancer (17.4%), bronchiectasis (6.8%), pulmonary oedema (4.2%), anticoagulants (3.5%), tuberculosis (2.7%), pulmonary embolism (2.6%) and aspergillosis (1.1%). Among incident cases, the 3-year recurrence rate was 16.3%. Of the initial cryptogenic haemoptysis patients, 4% were diagnosed with lung cancer within 3 years. Mortality rates during the first stay and at 1 and 3 years were 9.2%, 21.6% and 27%, respectively.This is the first epidemiological study analysing haemoptysis and its outcomes in an entire population. Haemoptysis is a life-threatening symptom unveiling potentially life-threatening underlying conditions.
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalier Universitaire du Bocage, Dijon, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Abdulmalak
authors.affiliation: Department of Medical Informatics, University Hospital, Dijon, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cottenet
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalier Universitaire du Bocage, Dijon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Beltramo
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalier Universitaire du Bocage, Dijon, France Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France.
authors.forename: Marjolaine
authors.initials: M
authors.lastname: Georges
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalier Universitaire du Bocage, Dijon, France Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France INSERM U866, Dijon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Camus
authors.affiliation: Service de Pneumologie et Soins Intensifs Respiratoires, Centre Hospitalier Universitaire du Bocage, Dijon, France Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France INSERM U866, Dijon, France Both authors contributed equally philippe.bonniaud@chu-dijon.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonniaud
authors.affiliation: Department of Medical Informatics, University Hospital, Dijon, France Faculty of Medicine and Pharmacy, University of Burgundy, Dijon, France INSERM U866, Dijon, France Both authors contributed equally.
authors.forename: Catherine
authors.initials: C
authors.lastname: Quantin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001987:Bronchiectasis / Q000150:complications*; D016208:Databases, Factual; D004621:Embolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006469:Hemoptysis / Q000209:etiology* / Q000401:mortality* / Q000628:therapy; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000150:complications*; D012008:Recurrence; D012189:Retrospective Studies