title: Biomarkers in Barrett's Esophagus: Role in Diagnosis, Risk Stratification, and Prediction of Response to Therapy.
abstract: Esophageal adenocarcinoma (EAC) has increased dramatically in the past 3 decades, making its precursor lesion Barrett's esophagus (BE) an important clinical problem. Effective interventions are available, but overall outcomes remain unchanged. Most of the BE population remains undiagnosed; most EACs are diagnosed late, and most BE patients will never progress to cancer. These epidemiologic factors make upper endoscopy an inefficient and ineffective strategy for BE diagnosis and risk stratification. In the current review, biomarkers for diagnosis, risk stratification, and predictors of response to therapy in BE are discussed.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Veterans Affairs Medical Center and the University of Kansas Medical Center, 4801 East Linwood Boulevard, Kansas City, MO 64128-2295, USA. Electronic address: abansal@kumc.edu.
authors.forename: Ajay
authors.initials: A
authors.lastname: Bansal
authors.affiliation: MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Fitzgerald
mesh_terms: D000782:Aneuploidy; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D019175:DNA Methylation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D018570:Risk Assessment; D000071165:Trefoil Factor-3; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs; D010455:Peptides; C082495:TFF3 protein, human; D000071165:Trefoil Factor-3; D016159:Tumor Suppressor Protein p53
keywords: Barrett’s esophagus; Biomarkers; Diagnosis; Esophageal adenocarcinoma; High-grade dysplasia; Response to therapy; Risk stratification; Screening