title: [Molecular biology of castration-resistant prostate cancer].
abstract: Castration-resistant prostate cancer was subjected to a paradigm switch from hormone resistance to androgen deprivation therapy resistance during the last decade. Indeed, new therapeutics targeting the androgen receptor showed clinical efficacy in patients with progressive disease under castration. Thus, it is a proof that the AR remains a dominant driver of oncogenesis in earlier-called hormone resistant prostate cancer. This review summarizes the molecular mechanisms involved in castration-resistant prostate cancer.
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, UFR de médecine, 75890 Paris cedex 18, France. Electronic address: ludovic.doucet@aphp.fr.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Doucet
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, UFR de médecine, 75890 Paris cedex 18, France.
authors.forename: Safae
authors.initials: S
authors.lastname: Terrisse
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gauthier
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Pouessel
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Le Maignan
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, UFR de médecine, 75890 Paris cedex 18, France.
authors.forename: Luis
authors.initials: L
authors.lastname: Teixeira
authors.affiliation: AP-HP, hôpital Saint-Louis, service d'oncologie médicale, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris-Diderot, UFR de médecine, 75890 Paris cedex 18, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
mesh_terms: D013196:Dihydrotestosterone / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D008297:Male; D009154:Mutation; D011467:Prostate / Q000378:metabolism; D064129:Prostatic Neoplasms, Castration-Resistant / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011944:Receptors, Androgen / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D011944:Receptors, Androgen; D013196:Dihydrotestosterone; D013739:Testosterone
keywords: Androgen receptor; Biologie moléculaire; Cancer de la prostate; Castration resistance; Molecular biology; Prostate cancer; Récepteur aux androgènes; Résistance à la castration