title: [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].
abstract: The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied. The efficiency of emoxipine, reamberin and mexidol was compared to alpha-lipoic acid, which is considered a "golden standard" in treatment of diabetic neuropathies. Emoxipine, reamberin and mexidol after seven administrations in single doses, that are equivalent to therapeutic range in humans, corrected the anxiety-depressive disorders in rats with alloxan diabetes. Unlike reamberin and alpha-lipoic acid, emoxipine and mexidol corrected the affective status concurrently with the decrease in hyperglycemia. At the same time, emoxipine outperformed mexidol in tranquilizing action (in maximal doses) but yielded mexidol in the antidepressant effect (in minimal doses).
authors.forename: L A
authors.initials: LA
authors.lastname: Volchegorskii
authors.forename: I Yu
authors.initials: IY
authors.lastname: Miroshnichenko
authors.forename: L M
authors.initials: LM
authors.lastname: Rassokhina
authors.forename: R M
authors.initials: RM
authors.lastname: Faizullin
authors.forename: K E
authors.initials: KE
authors.lastname: Pryakhina
authors.forename: A V
authors.initials: AV
authors.lastname: Kalugina
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives; D010847:Picolines / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage*; D051381:Rats; D013386:Succinates / Q000008:administration & dosage; D019802:Succinic Acid / Q000008:administration & dosage*; D008063:Thioctic Acid / Q000008:administration & dosage
chemical_list: C457919:3-oxypyridine; D014151:Anti-Anxiety Agents; D010847:Picolines; D011725:Pyridines; C549374:Reamberin; D013386:Succinates; C070020:emoxypine succinate; D008536:Meglumine; D008063:Thioctic Acid; D019802:Succinic Acid; C009820:6-methyl-2-ethyl-3-hydroxypyridine