title: Retinal oxygen saturation in retinitis pigmentosa and macular dystrophies in asian-Indian eyes.
abstract: OBJECTIVE
  To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls.
  
  
  METHODS
  In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retinal oximeter. The images were analyzed for oxygen saturation and diameter of retinal vessels.
  
  
  RESULTS
  All parameters showed a significant difference among the three groups. Patients with RP showed significantly lower diameters (98.4 μm and 136.9 μm arteriolar and venous) (P < 0.001), higher saturations (102.3% and 59.1%) (P < 0.001; 0.06), and higher arterio-venous saturation difference (AVSD) (43%) (P < 0.001) compared with the other two groups. Macular dystrophies showed higher global arteriolar values (96.7%) and AVSD (41.6%) but comparable venous values (54.9%) to the control group (90.6%, 57.4%, and 33.3%).
  
  
  CONCLUSIONS
  Oximetry is sensitive in quantifying hemodynamic changes in retinal dystrophies. It is still unclear whether these hemodynamic changes are a cause or a result of the disease process.
authors.forename: Rajani
authors.initials: R
authors.lastname: Battu
authors.forename: Ashwin
authors.initials: A
authors.lastname: Mohan
authors.forename: Anjani
authors.initials: A
authors.lastname: Khanna
authors.forename: Abhinav
authors.initials: A
authors.lastname: Kumar
authors.forename: Rohit
authors.initials: R
authors.lastname: Shetty
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology; D012171:Retinal Vessels / Q000378:metabolism* / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D010100:Oxygen