title: Idiopathic pulmonary fibrosis and sleep disorders: no longer strangers in the night.
abstract: The prevalence of obstructive sleep apnoea (OSA) is continuously increasing in patients with idiopathic pulmonary fibrosis (IPF) and, for the first time, the recent IPF guidelines recognise OSA as an important associated comorbidity that can affect patient's survival. Thus, it becomes conceivable that clinicians should refer patients with newly diagnosed IPF to sleep centres for the diagnosis and treatment of OSA as well as for addressing issues regarding the reduced compliance of patients with continuous positive airway pressure therapy. The discovery of biomarkers common to both disorders may help early diagnosis, institution of the most appropriate treatment and follow-up of patients. Better understanding of epigenetic changes may provide useful information about pathogenesis and, possibly, development of new drugs for a dismal disease like IPF.
authors.affiliation: Dept of Thoracic Medicine, Sleep Disorders Center, Medical School, University of Crete, Heraklion, Greece Both authors contributed equally.
authors.forename: Sophia
authors.initials: S
authors.lastname: Schiza
authors.affiliation: Dept of Thoracic Medicine, Sleep Disorders Center, Medical School, University of Crete, Heraklion, Greece Both authors contributed equally.
authors.forename: Charalampos
authors.initials: C
authors.lastname: Mermigkis
authors.affiliation: Dept of Thoracic Medicine, Interstitial Lung Disease Unit & Laboratory of Molecular and Cellular Pneumonology, Medical School, University of Crete, Heraklion, Greece Dept of Respiratory Medicine, General Hospital of Kavala, Kavala, Greece.
authors.forename: George A
authors.initials: GA
authors.lastname: Margaritopoulos
authors.affiliation: Respiratory Medicine Dept, University Hospital of Larissa, Larissa, Greece.
authors.forename: Zoi
authors.initials: Z
authors.lastname: Daniil
authors.affiliation: U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica, Milan, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Harari
authors.affiliation: Dept of Diseases of the Thorax/Pulmonology Unit, Ospedale GB Morgagni, Forlì, Italy.
authors.forename: Venerino
authors.initials: V
authors.lastname: Poletti
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.
authors.forename: Elizabetta A
authors.initials: EA
authors.lastname: Renzoni
authors.affiliation: U.O. di Pneumologia e Terapia Semi-Intensiva Respiratoria, Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare, Ospedale San Giuseppe - MultiMedica, Milan, Italy.
authors.forename: Olga
authors.initials: O
authors.lastname: Torre
authors.affiliation: Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.
authors.forename: Dina
authors.initials: D
authors.lastname: Visca
authors.affiliation: Dept of Thoracic Medicine, Sleep Disorders Center, Medical School, University of Crete, Heraklion, Greece.
authors.forename: Isolde
authors.initials: I
authors.lastname: Bouloukaki
authors.affiliation: Laboratory of Virology, Medical School, University of Crete, Heraklion, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Sourvinos
authors.affiliation: Dept of Thoracic Medicine, Interstitial Lung Disease Unit & Laboratory of Molecular and Cellular Pneumonology, Medical School, University of Crete, Heraklion, Greece kantoniou@med.uoc.gr.
authors.forename: Katerina M
authors.initials: KM
authors.lastname: Antoniou
mesh_terms: D015897:Comorbidity; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000503:physiopathology; D000860:Hypoxia / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D010102:Oxygen Inhalation Therapy; D010641:Phenotype; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D012890:Sleep; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
chemical_list: D005819:Genetic Markers