title: Anticancer Camptothecin-N-Poly(lactic acid) Nanoconjugates with Facile Hydrolysable Linker.
abstract: We report a strategy of conjugating CPT to the terminal carboxylate group of polylactide (PLA) with a facile hydrolysable amino ester linker via a controlled polymerization method. The obtained CPT-N-PLA conjugates were able to self-assemble into 50-100 nanometer-sized conjugates (NCs) with desiredin vitrophysicochemical properties and showed enhancedin vivotherapeutic efficacy against Lewis lung carcinoma (LLC) induced in C57BL/6 mice.
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
authors.forename: Qian
authors.initials: Q
authors.lastname: Yin
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
authors.forename: Rong
authors.initials: R
authors.lastname: Tong
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
authors.forename: Lichen
authors.initials: L
authors.lastname: Yin
authors.affiliation: Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Fan
authors.affiliation: Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801 (USA).
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng