title: The prognostic factors and multiple biomarkers in young patients with colorectal cancer.
abstract: The incidence of colorectal cancer (CRC) in young patients (≤ 50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to analyse clinicopathological characteristics, survival and multiple biomarkers of young CRC patients. A total of 509,934 CRC patients were included from the three databases. The young CRC patients tended to have more distal location tumours, fewer tumour numbers, later stage, more mucinous carcinoma and poorer differentiation. The cancer-specific survival (CSS) of young patients was significantly better. The PRL (HR = 12.341, 95% CI = 1.615-94.276, P = 0.010), RBM3 (HR = 0.093, 95% CI = 0.012-0.712, P = 0.018), Wrap53 (HR = 1.952, 95% CI = 0.452-6.342, P = 0.031), p53 (HR = 5.549, 95% CI = 1.176-26.178, P = 0.045) and DNA status (HR = 17.602, 95% CI = 2.551-121.448, P = 0.001) were associated with CSS of the young patients. In conclusion, this study suggests that young CRC patients present advanced tumours and more malignant pathological features, while they have a better prognosis. The PRL, RBM3, Wrap53, p53 and DNA status are potential prognostic biomarkers for the young CRC patients.
authors.affiliation: 1] Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2] Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SE 58183, Sweden.
authors.forename: Mo-Jin
authors.initials: MJ
authors.lastname: Wang
authors.affiliation: Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SE 58183, Sweden.
authors.forename: Jie
authors.initials: J
authors.lastname: Ping
authors.affiliation: Department of Paediatric Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SE 58183, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Adell
authors.affiliation: Department of Surgery, and Department of Clinical and Experimental Medicine, Linköping University, Norrköping, SE 60174, Sweden.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Arbman
authors.affiliation: Department of pathology, Lund University, Lund, SE 22100, Sweden.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Nodin
authors.affiliation: 1] Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2] Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SE 58183, Sweden.
authors.forename: Wen-Jian
authors.initials: WJ
authors.lastname: Meng
authors.affiliation: School of Medicine, Örebro University, Örebro, SE 70182, Sweden.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Yong-Yang
authors.initials: YY
authors.lastname: Yu
authors.affiliation: Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Cun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Lie
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
authors.forename: Zong-Guang
authors.initials: ZG
authors.lastname: Zhou
authors.affiliation: 1] Department of Gastrointestinal Surgery, Institute of Digestive Surgery and State key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [2] Department of Oncology, and Department of Clinical and Experimental Medicine, Linköping University, Linköping, SE 58183, Sweden.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D016208:Databases, Factual; D003710:Demography; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D018832:Molecular Chaperones; D009367:Neoplasm Staging; D011379:Prognosis; D011388:Prolactin / Q000235:genetics / Q000378:metabolism; D016016:Proportional Hazards Models; D060066:Protein Interaction Maps; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018832:Molecular Chaperones; C099506:RBM3 protein, human; D016601:RNA-Binding Proteins; D016159:Tumor Suppressor Protein p53; D011388:Prolactin; D019098:Telomerase; C535133:WRAP53 protein, human