title: Aflibercept for the treatment of neovascular glaucoma.
abstract: BACKGROUND
  Neovascular glaucoma (NVG) is a potentially blinding disease associated with ocular ischaemia. Use of an anti-vascular endothelial growth factor agent has been reported as a treatment option for NVG. The purpose of this study was to investigate initial results regarding the treatment of NVG with intravitreal aflibercept.
  
  
  METHODS
  This study employed a prospective, interventional case series study design.
  
  
  METHODS
  Patients with newly diagnosed stage 1 or 2 neovascular glaucoma were eligible to participate in this study.
  
  
  METHODS
  Four patients with newly diagnosed stage 1 or 2 NVG were treated with intravitreal aflibercept at the time of diagnosis, with planned repeat injection at 4 weeks, 8 weeks and then every 8 weeks thereafter up until 52 weeks after study initiation.
  
  
  METHODS
  Primary outcomes were regression of neovascularization of the iris and angle (NVI, NVA). Secondary outcome measurements included visual acuity and intraocular pressure (IOP).
  
  
  RESULTS
  Intravitreal aflibercept resulted in rapid regression of NVI and NVA. IOP was stable or reduced in all patients at the 52-week study visit.
  
  
  CONCLUSIONS
  These results suggest that intravitreal aflibercept may be an effective treatment for stage 1 and 2 NVG, resulting in rapid and sustained regression of NVI and NVA as well as control of IOP. Further research is needed to determine the full duration of effect and the optimal dose and timing of administration.
authors.affiliation: Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: SooHoo
authors.affiliation: Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Leonard K
authors.initials: LK
authors.lastname: Seibold
authors.affiliation: Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Mina B
authors.initials: MB
authors.lastname: Pantcheva
authors.affiliation: Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Malik Y
authors.initials: MY
authors.lastname: Kahook
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D005260:Female; D015355:Glaucoma, Neovascular / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D040262:Receptors, Vascular Endothelial Growth Factor / Q000627:therapeutic use*; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use*; D014065:Tonometry, Ocular; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D011993:Recombinant Fusion Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C533178:aflibercept; D040262:Receptors, Vascular Endothelial Growth Factor
keywords: glaucoma; intraocular pressure; neovascularization; vascular endothelial growth factor