title: Autologous Hematopoietic Stem Cell Transplantation-10 Years of Data From a Developing Country.
abstract: Intensive chemotherapy followed by autologous stem cell transplantation is the treatment of choice for patients with hematological malignancies. The objective of the present study was to evaluate the outcomes of patients with mainly lymphoma and multiple myeloma after autologous stem cell transplant. The pretransplant workup consisted of the complete blood count, an evaluation of the liver, kidney, lung, and infectious profile, chest radiographs, and a dental review. For lymphoma, all patients who achieved at least a 25% reduction in the disease after salvage therapy were included in the study. Mobilization was done with cyclophosphamide, followed by granulocyte colony-stimulating factor, 300 µg twice daily. The conditioning regimens included BEAM (carmustine, etoposide, cytarabine, melphalan) and high-dose melphalan. A total of 206 transplants were performed from April 2004 to December 2014. Of these, 137 were allogeneic transplants and 69 were autologous. Of the patients receiving an autologous transplant, 49 were male and 20 were female. Of the 69 patients, 26 underwent transplantation for Hodgkin's lymphoma, 23 for non-Hodgkin's lymphoma, and 15 for multiple myeloma and 4 and 1 for Ewing's sarcoma and neuroblastoma, respectively. The median age ± SD was 34 ± 13.1 years (range, 4-64). A mean of 4.7 × 10⁸ ± 1.7 mononuclear cells per kilogram were infused. The median time to white blood cell recovery was 18.2 ± 5.34 days. Transplant-related mortality occurred in 10 patients. After a median follow-up period of 104 months, the overall survival rate was 86%. High-dose chemotherapy, followed by autologous stem cell transplant, is an effective treatment option for patients with hematological malignancies, allowing further consolidation of response.
authors.affiliation: Department of Pathology & Laboratory Medicine/Oncology, The Aga Khan University, Karachi, Pakistan natasha.ali@aku.edu.
authors.forename: Natasha
authors.initials: N
authors.lastname: Ali
authors.affiliation: Department of Pathology & Laboratory Medicine/Oncology, The Aga Khan University, Karachi, Pakistan.
authors.forename: Salman Naseem
authors.initials: SN
authors.lastname: Adil
authors.affiliation: Department of Pathology & Laboratory Medicine/Oncology, The Aga Khan University, Karachi, Pakistan.
authors.forename: Mohammad Usman
authors.initials: MU
authors.lastname: Shaikh
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous / Q000009:adverse effects*
chemical_list: D003561:Cytarabine; D008558:Melphalan
keywords: Autologous transplant; Lymphoma; Multiple myeloma