title: Paediatric retinoblastoma in India: evidence from the National Cancer Registry Programme.
abstract: BACKGROUND
  Globally, retinoblastoma is the most common primary intraocular malignancy occurring in children. This paper documents the recent incidence rates of retinoblastoma by age and sex groups from the Population Based Cancer Registries (PBCRs) of Bangalore, Mumbai, Chennai, Delhi and Kolkata using the data from the National Cancer Registry Programme.
  
  
  METHODS
  Relative proportions, sex ratio, method of diagnosis, and incidence rates (crude and age standardized) for each PBCR and pooled rates of the five PBCRs were calculated for the years 2005/06 to 2009/10. Standard errors and 95% confidence limits of ASIRs by sex group in each PBCR were calculated using the Poisson distribution. Standardised rate ratios of ASIR by sex group and rate ratios at risk were also calculated.
  
  
  RESULTS
  The maximum retinoblastoma cases were in the 0-4 age group, accounting for 78% (females) and 81% (males) of pooled cases from five PBCRs. The pooled crude incidence rate in the 0-14 age group was 3.5 and the pooled ASIR was 4.4 per million. The pooled ASIR in the 0-4, 5-9 and 10-14 age group were 9.6, 2.0 and 0.1 respectively. The M/F ratio in Chennai (1.9) and Bangalore PBCRs (2.0) was much higher than the other PBCRs. Among the PBCRs, the highest incidence rate in 0-4 age group was found in males in Chennai (21.7 per million), and females in Kolkata (18.9 per million). There was a distinct variation in incidence rates in the PBCRs in different geographic regions of India.
authors.affiliation: National Centre for Disease Informatics and Research, Indian Council of Medical Research, India E-mail : ank@blr.vsnl.net.in.
authors.forename: Sukanya
authors.initials: S
authors.lastname: Rangamani
authors.forename: Krishnan
authors.initials: K
authors.lastname: SathishKumar
authors.forename: N
authors.initials: N
authors.lastname: Manoharan
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Julka
authors.forename: Goura Kishor
authors.initials: GK
authors.lastname: Rath
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Shanta
authors.forename: Rajaraman
authors.initials: R
authors.lastname: Swaminathan
authors.forename: Ranganathan
authors.initials: R
authors.lastname: Rama
authors.forename: Karabi
authors.initials: K
authors.lastname: Datta
authors.forename: Syamsundar
authors.initials: S
authors.lastname: Mandal
authors.forename: Shravani
authors.initials: S
authors.lastname: Koyande
authors.forename: Vinay
authors.initials: V
authors.lastname: Deshmane
authors.forename: B
authors.initials: B
authors.lastname: Ganesh
authors.forename: Shripad D
authors.initials: SD
authors.lastname: Banavali
authors.forename: Rajendra A
authors.initials: RA
authors.lastname: Badwe
authors.forename: C
authors.initials: C
authors.lastname: Ramesh
authors.forename: Lingappa
authors.initials: L
authors.lastname: Appaji
authors.forename: Ambakumar
authors.initials: A
authors.lastname: Nandakumar
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D002947:Cities / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012042:Registries; D019572:Retinal Neoplasms / Q000453:epidemiology*; D012175:Retinoblastoma / Q000453:epidemiology*; D017678:Sex Distribution