title: Two cases of breast carcinoma during pregnancy and review of the literature.
abstract: Pregnancy-associated breast cancer is the most common solid tumor in pregnancy after cervical carcinoma but still has a low incidence. It has been associated with a poor prognosis; though based on a limited number of retrospective case-control studies, some authors have reported no differences from that of non-pregnant patients. There is no consensus about the treatment; it requires an interdisciplinary approach and it is necessary to balance between the benefit for the mother and risk for the fetus. Each case requires an individual decision taking into account the stage of disease, patient preferences and gestational age. Above chemotherapy, it is only recommended after the first trimester of pregnancy and anthracyclin-based schemes have the higher evidence, but taxanes are also considered as an alternative in patients who do not respond to anthracyclines or its use is contraindicated. For the time being, there is a lack of data, and clinical decisions are based on small retrospective cohorts, case-control studies and case reports. We report two cases of patients being diagnosed with breast cancer while being pregnant and treated with surgery and chemotherapy, including anthracyclines, during the second and third trimester of pregnancy. In both reported cases, childbirth was induced before the 37th week of gestation and only one presented low birth weight with no more complications. The echocardiogram monitorization showed normal cardiac function in mothers and fetus.
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain Oihana.84@gmail.com.
authors.forename: Oihana
authors.initials: O
authors.lastname: Pascual
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Moisés
authors.initials: M
authors.lastname: Uriarte
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Agustín
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Gimeno
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Itziar
authors.initials: I
authors.lastname: Larrodé
authors.affiliation: Pharmacy Department, Miguel Servet University Hospital, Zaragoza, Spain.
authors.forename: Maria-Reyes
authors.initials: MR
authors.lastname: Abad
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011256:Pregnancy Outcome
keywords: Breast cancer; chemotherapy; pregnancy