title: [Knotted proteins].
abstract: For a long time the presence of knots in a protein structure was not admitted. However, the existence of proteins with various types of knots has now been proven. The functional significance of knotted topology remains unclear despite numerous assumptions. Studing the structure of knots in proteins and their impact on the acquisition of native structure of proteins is important for the understanding of protein folding as a whole. We review the types of knots in the proteins discovered to date, including trefoil knot, figure-of-eight knot, and more complex knots with 5 and 6 crossings of polypeptide chain. We survey the folding of knotted proteins as well.
authors.forename: Olesya V
authors.initials: OV
authors.lastname: Stepanenko
authors.forename: G S
authors.initials: GS
authors.lastname: Bublikov
authors.forename: Olga V
authors.initials: OV
authors.lastname: Stepanenko
authors.forename: G N
authors.initials: GN
authors.lastname: Rychkov
authors.forename: O I
authors.initials: OI
authors.lastname: Povarova
authors.forename: V V
authors.initials: VV
authors.lastname: Verkhusha
authors.forename: K K
authors.initials: KK
authors.lastname: Turoverov
authors.forename: I M
authors.initials: IM
authors.lastname: Kuznetsova
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry*; D057771:Cystine-Knot Miniproteins / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D010834:Phytochrome / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012359:tRNA Methyltransferases / Q000737:chemistry*
chemical_list: D001426:Bacterial Proteins; D057771:Cystine-Knot Miniproteins; D010940:Plant Proteins; D010834:Phytochrome; D012359:tRNA Methyltransferases