title: Lupus enteritis during pregnancy: A case-based review.
abstract: Although the symptoms of systemic lupus erythematosus (SLE) worsen during pregnancy, few previous studies have reported lupus enteritis in pregnant women with SLE. A 29-year-old pregnant Japanese woman presented with acute abdomen. Six years before pain onset, she developed pure red cell aplasia and tested positive for anti-Ro (SS-A) and anti-La (SS-B) antibodies. Anti-DNA antibodies were detected two and a half years later. The patient remained asymptomatic until she developed acute abdomen. A mild increase in anti-DNA antibody levels and a mild decrease in complement levels were observed, and abdominal ultrasound and magnetic resonance imaging revealed the presence of large-volume ascites and edematous thickening of the small intestinal wall. These findings established the diagnosis of lupus enteritis. Her condition improved after treatment with prednisolone 50 mg/day, and she delivered a female infant weighing approximately 1810 g at 37 weeks of gestation. Our study suggests that lupus enteritis should be suspected in female patients with autoimmune disease who develop acute abdomen during pregnancy, and that magnetic resonance imaging is useful in its diagnosis.
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.|b Department of General Internal medicine , National Hospital Organization Tokyo Medical Center , Meguro-ku , Tokyo , Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Nagakawa
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Arata
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.
authors.forename: Asako
authors.initials: A
authors.lastname: Mito
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.
authors.forename: Terumi
authors.initials: T
authors.lastname: Kaneshige
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.|c Department of Diagnostic Radiology , Tohoku University Hospital , Miyagi , Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kitami
authors.affiliation: d Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.affiliation: a Department of Obstetric Medicine , Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.|d Center for Maternal-Fetal-Neonatal and Reproductive Medicine, National Center for Child Health and Development , Setagaya-ku , Tokyo , Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Murashima
mesh_terms: D000006:Abdomen, Acute / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000097:blood; D004751:Enteritis / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014463:Ultrasonography
chemical_list: D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D011239:Prednisolone
keywords: Enteritis; Lupus erythematosus; Pregnancy; Pure; Red cell aplasia; Systemic