title: Could the thromboxane A2 pathway be a therapeutic target for the treatment of obstructive sleep apnea-induced atherosclerosis?
abstract: Obstructive sleep apnea (OSA) is characterized by recurrent nocturnal episodes of intermittent hypoxia. This disease is associated with premature atherosclerosis and consequently with increased cardiovascular morbidity and mortality. Atherosclerosis is a chronic inflammatory disease characterized by the activation of some components of the cyclooxygenase pathway. In particular, OSA is associated with activation of the thromboxane A2 (TXA2)-pathway, in which obesity seems to be a major confounding factor. Moreover, TXA2-pathway activation is related to the vascular remodeling associated with OSA. In view of the modest effect of the conventional treatment of OSA by continuous positive airway pressure on the cardiovascular risk in obese OSA patients, the identification of new therapeutic targets to treat OSA-induced atherosclerosis seems essential. As disruption of the TXA2-pathway has been suggested to be of potential interest to prevent atherosclerosis progression, we have reviewed the recent findings on the intricate interaction between the TXA2-pathway, chronic intermittent hypoxia and atherosclerosis and suggest promising therapeutic strategies to treat OSA-related atherogenesis, including pharmacological and/or nutritional approaches.
authors.affiliation: Univ Grenoble Alpes, F-38041 Grenoble, France; INSERM U1042, HP2, F-38041 Grenoble, France; Centre Hospitalier Universitaire de Grenoble, Hôpital Albert Michalon, F-38043 Grenoble, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Gautier-Veyret
authors.affiliation: Univ Grenoble Alpes, F-38041 Grenoble, France; INSERM U1042, HP2, F-38041 Grenoble, France; Centre Hospitalier Universitaire de Grenoble, Hôpital Albert Michalon, F-38043 Grenoble, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Van Noolen
authors.affiliation: Univ Grenoble Alpes, F-38041 Grenoble, France; INSERM U1042, HP2, F-38041 Grenoble, France; Centre Hospitalier Universitaire de Grenoble, Hôpital Albert Michalon, F-38043 Grenoble, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Lévy
authors.affiliation: Univ Grenoble Alpes, F-38041 Grenoble, France; INSERM U1042, HP2, F-38041 Grenoble, France; Centre Hospitalier Universitaire de Grenoble, Hôpital Albert Michalon, F-38043 Grenoble, France.
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Pepin
authors.affiliation: Univ Grenoble Alpes, F-38041 Grenoble, France; INSERM U1042, HP2, F-38041 Grenoble, France; Centre Hospitalier Universitaire de Grenoble, Hôpital Albert Michalon, F-38043 Grenoble, France. Electronic address: FStanke@chu-grenoble.fr.
authors.forename: Françoise
authors.initials: F
authors.lastname: Stanke-Labesque
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000178:diet therapy / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D000860:Hypoxia / Q000150:complications; D058990:Molecular Targeted Therapy / Q000379:methods*; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D013928:Thromboxane A2 / Q000378:metabolism*
chemical_list: D013928:Thromboxane A2
keywords: Atherosclerosis; Intermittent hypoxia; Obstructive sleep apnea; Thromboxane A(2)