title: Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear.
abstract: T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A-E (1-5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (-)-3, and (±)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.|#Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China.
authors.forename: Feng-Jiao
authors.initials: FJ
authors.lastname: Zhou
authors.affiliation: §Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Nian
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.|‡University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Yan
authors.affiliation: §Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Gong
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.|‡University of Chinese Academy of Sciences, Beijing 100049, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Zuo
authors.affiliation: #Guangdong Pharmaceutical University, Guangzhou 510006, P.R. China.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Wang
authors.affiliation: §Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China.
authors.forename: He-Hai
authors.initials: HH
authors.lastname: Jiang
authors.affiliation: §Key Laboratory of Animal Models and Human Disease Mechanisms, and Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, P.R. China.|∥Department of Biological Sciences, Columbia University, New York, New York 10027, United States.
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.affiliation: †State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P.R. China.
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D020864:Calcium Channels, N-Type / Q000737:chemistry* / Q000378:metabolism; D020747:Calcium Channels, T-Type / Q000737:chemistry* / Q000378:metabolism; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D020747:Calcium Channels, T-Type; D013729:Terpenes; C000602929:cochlearine A; C000602930:cochlearine B