title: Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study.
abstract: OBJECTIVE
  To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex.
  
  
  METHODS
  Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified.
  
  
  RESULTS
  A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36 ± 11 years). The mean parafoveal flow index was 0.099 ± 0.013; the mean vessel area density was 0.891 ± 0.073; and the mean CFZ area was 0.474 ± 0.172 mm2. All three parameters were significantly correlated with age (flow index: P = 0.00; vessel area density: P = 0.00; CFZ area: P = 0.02). The flow index and vessel area density decreased annually by 0.6% and 0.4%, respectively, and CFZ area increased by 1.48% annually. The CFZ area was larger in females than in males, while all three parameters seemed to change more rapidly with age in males than in females.
  
  
  CONCLUSIONS
  In healthy Chinese eyes, macular perfusion decreased with increasing age, and decreased more rapidly in males than in females. The application of OCT angiograms may provide a useful approach for monitoring macular perfusion, although caution must be exercised with regard to age- and sex-related variations.
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Ruiping
authors.initials: R
authors.lastname: Gu
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Huan
authors.initials: H
authors.lastname: Xu
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Myopia of State Health Ministry, and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
mesh_terms: D000328:Adult; D000367:Age Factors; D000465:Algorithms; D044466:Asian People; D001783:Blood Flow Velocity; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply; D006801:Humans; D008266:Macula Lutea / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000033:anatomy & histology*; D012737:Sex Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult