title: Regulation of TRPML1 function.
abstract: TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.
authors.affiliation: *School of Biosciences, Sir Martin Evans building, Cardiff University, Museum Avenue, Cardiff, CF15 8AZ, U.K.
authors.forename: Helen
authors.initials: H
authors.lastname: Waller-Evans
authors.affiliation: *School of Biosciences, Sir Martin Evans building, Cardiff University, Museum Avenue, Cardiff, CF15 8AZ, U.K.
authors.forename: Emyr
authors.initials: E
authors.lastname: Lloyd-Evans
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D011992:Endosomes / Q000235:genetics; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008247:Lysosomes / Q000235:genetics; D009081:Mucolipidoses / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D050051:Transient Receptor Potential Channels / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C416674:MCOLN1 protein, human; D050051:Transient Receptor Potential Channels