title: Prognostic value of age in neurological cancer: an analysis of 22,393 cases from the SEER database.
abstract: Although the risk of neurological cancer (NC) is age-dependent, few studies have evaluated the prognostic value of age in determining NC survival in a large population. The aim of this retrospective study was to compare the long-term survival of young and elderly NC patients. We searched the Surveillance, Epidemiology, and End-Results database and identified 22,393 patients who were diagnosed with NC between 1988 and 2003 and were treated with surgery. Patients were categorized as young (≤40 years old) or elderly (>40 years old), and 5-year NC-specific survival (NCSS) data were obtained for each patient. A Kaplan-Meier survival analysis and the Cox proportional hazards model were used to analyze long-term survival outcomes and risk factors. The two groups differed significantly in terms of pathological grade, histological type, stage, and tumor size (P < 0.001). A difference in 5-year NCSS rates (63.8 and 19.0% in young and elderly patients, respectively) was detected by uni- and multivariate analyses. A stratified analysis of age on cancer survival revealed significant differences at T1-T4 stages. Age has prognostic value for determining NC risk. NCSS is higher in young than in elderly NC patients.
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Minjie
authors.initials: M
authors.lastname: Tian
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Donglin
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Daowen
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Huo
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, P.O. Box 210029, No. 264 Guangzhou Road, Nanjing, People's Republic of China. profshijp@163.com.
authors.forename: Jingping
authors.initials: J
authors.lastname: Shi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D009422:Nervous System Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors
keywords: Age; Brain cancer; SEER