title: Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats.
abstract: We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.
authors.affiliation: Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia, ekhirazova@gmail.com.
authors.forename: E E
authors.initials: EE
authors.lastname: Khirazova
authors.forename: A A
authors.initials: AA
authors.lastname: Bayzhumanov
authors.forename: E S
authors.initials: ES
authors.lastname: Motorykina
authors.forename: A A
authors.initials: AA
authors.lastname: Devyatov
authors.forename: M V
authors.initials: MV
authors.lastname: Maslova
authors.forename: A V
authors.initials: AV
authors.lastname: Graf
authors.forename: N A
authors.initials: NA
authors.lastname: Sokolova
authors.forename: M G
authors.initials: MG
authors.lastname: Golubeva
authors.forename: A A
authors.initials: AA
authors.lastname: Kamenskii
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001067:Appetite Depressants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002374:Catalase / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D008297:Male; D008969:Molecular Sequence Data; D050177:Overweight / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D036361:Peptide Hormones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D001067:Appetite Depressants; D010446:Peptide Fragments; D036361:Peptide Hormones; C505798:obestatin, rat; D002374:Catalase; D013482:Superoxide Dismutase