title: Outcomes of inhaled nitric oxide in preterm neonates - a five-year experience in a tertiary neonatal centre.
abstract: OBJECTIVE
  To review the outcome of preterm neonates treated with iNO.
  
  
  METHODS
  The neonatal electronic database was reviewed between April 1, 2009 and March 31, 2014.
  
  
  RESULTS
  In the five-year period, 142 babies were treated with iNO. Forty-two preterm neonates <34(+0)  weeks were included in this review. During this period, the use of iNO in preterm neonates <26(+0)  weeks rose from 1.4% to 4.8% and the mortality was significantly higher in this group (69%).
  
  
  CONCLUSIONS
  There is an increasing trend in using iNO as a rescue treatment in preterm neonates. The outcomes were very poor in the preterm neonates <26(+0)  weeks. A cautious approach is warranted in the absence of robust evidence to support the use of iNO, in preterm neonates <26(+0)  weeks.
authors.affiliation: Birmingham Women's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Supriya
authors.initials: S
authors.lastname: Gaddam Bhoomaiah
authors.affiliation: Birmingham Women's Hospital NHS Foundation Trust, Birmingham, UK.
authors.forename: Shree Vishna
authors.initials: SV
authors.lastname: Rasiah
mesh_terms: D000280:Administration, Inhalation; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D015931:Intensive Care, Neonatal; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use*; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D063128:Tertiary Health Care; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D009569:Nitric Oxide
keywords: Neonates; Nitric oxide; Preterm and outcomes