title: Histopathological features of hypertrophic bone mass of temporomandibular joint ankylosis (TMJA): An explanation of pathogenesis of TMJA.
abstract: Temporomandibular joint ankylosis (TMJA) is a severe organic disease with progressive limitation of the mouth opening. Histopathologically, a residual joint space is reported to consist of fibrous tissue and/or cartilage, indicating two types of interface (osteo-fibrous and osteo-chondral) of residual joint space. It is well known that adverse mechanical stress results in pathological changes of osteoarthritis and enthesopathy in these interfaces. What would happen pathologically in these interfaces of TMJA under repeated mandible movement has not been elucidated. Fourteen tissue samples of residual joint space and temporal and condylar bone were stained with hematoxylin and eosin and evaluated by collagen I and II immunohistochemistry. A pathological study of 14 TMJA patients showed that the residual joint space presented a fibrocartilage entheses structure and an articular cartilage structure. Moreover, these two structures were associated with pathological alterations of both osteoarthritis and enthesopathy, including degenerated and necrotized tissue, chondrocyte cloning, crack and fissure, various bone scleroses, and inflammatory granulation tissue. It is suggested that the pathological alterations of both osteoarthritis and enthesopathy occurred in TMJA, which hints at mechanical stress on TMJA development.
authors.affiliation: Department of General Dentistry (Chair: Dr. Jie Pan), Peking University, School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Denghui
authors.initials: D
authors.lastname: Duan
authors.affiliation: Department of Oral and Maxillofacial Surgery (Chair: Dr. Yi Zhang), Peking University, School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Jiangming
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery (Chair: Dr. Yi Zhang), Peking University, School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: E
authors.initials: E
authors.lastname: Xiao
authors.affiliation: Department of Oral and Maxillofacial Surgery (Chair: Dr. Yi Zhang), Peking University, School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Linhai
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Oral and Maxillofacial Surgery (Chair: Dr. Ping Zhang), Tianjin Stomatological Hospital, 75 Dagu Road, Heping District, Tianjin 300041, China.
authors.forename: Yingbin
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Oral Pathology (Chair: Dr. Yan Gao), Peking University, School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Oral and Maxillofacial Surgery (Chair: Dr. Yi Zhang), Peking University, School and Hospital of Stomatology, Beijing 100081, China. Electronic address: zhangyi2000@263.net.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000844:Ankylosis / Q000209:etiology / Q000473:pathology*; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D019902:Chondrocytes / Q000473:pathology; D024042:Collagen Type I / Q000032:analysis; D024043:Collagen Type II / Q000032:analysis; D005260:Female; D051445:Fibrocartilage / Q000473:pathology; D005355:Fibrosis; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D015576:Hyperostosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000473:pathology; D010020:Osteonecrosis / Q000473:pathology; D010026:Osteosclerosis / Q000473:pathology; D013314:Stress, Mechanical; D013701:Temporal Bone / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000209:etiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II
keywords: Enthesopathy; Osteoarthritis; Pathogenesis; Temporomandibular joint ankylosis