title: Gastric diffuse hamartomatous polyposis as unique manifestation of peutz-jeghers syndrome.
abstract: BACKGROUND
  Peutz-Jeghers-type hamartomatous polyps are most common in the small intestine, but can also occur in the stomach and large bowel. Gastric polyps usually coexist with hamartomatous polyps in other locations of the gastro-intestinal tract. We present the second case reported in literature of diffuse gastric polyposis without affecting the rest of the gastrointestinal tract.
  
  
  METHODS
  A 41-years-old woman complained of repeated, self-limited episodes of hematemesis. She presented with anaemia. An upper gastrointestinal endoscopy revealed multiple polyps in all the gastric surface, whose biopsy diagnosed of hamartomatous polyps. No other polyps were detecting the gastrointestinal tract. The patient underwent a total gastrectomy with Roux-en-Y reconstruction. Pathology revealed a gastric diffuse hamartomatous polyposis. A mis-sense mutation encoding the serine/threonine kinase STK11 gene was been identified, compatible with Peutz Jeghers polyposis.
authors.affiliation: Department of General and Digestive Surgery, General University Hospital Elche, Alicante, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ruiz-Tovar
authors.forename: C
authors.initials: C
authors.lastname: Gamallo
mesh_terms: D000328:Adult; D001706:Biopsy; D053704:Capsule Endoscopy; D003937:Diagnosis, Differential; D005260:Female; D006222:Hamartoma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D010580:Peutz-Jeghers Syndrome / Q000150:complications / Q000175:diagnosis*; D013272:Stomach Diseases / Q000175:diagnosis / Q000209:etiology*