title: Rethinking risk for pneumococcal disease in adults: the role of risk stacking.
abstract: Using data from 3 private healthcare claims repositories, we evaluated the incidence of pneumococcal disease among adults with US Advisory Committee on Immunization Practices (ACIP) defined at-risk conditions or rheumatoid arthritis, lupus, Crohn's disease, and neuromuscular disorder/seizures and those with traditional high-risk conditions. We observed that adults with ≥2 concurrent comorbid conditions had pneumococcal disease incidence rates that were as high as or higher than rates observed in those with traditional high-risk conditions.
authors.affiliation: Boston University Schools of Medicine and Public Health ; Boston Medical Center.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Pelton
authors.affiliation: Boston University Schools of Medicine and Public Health.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Shea
authors.affiliation: Policy Analysis Inc. , Brookline, Massachusetts.
authors.forename: Derek
authors.initials: D
authors.lastname: Weycker
authors.affiliation: Pfizer Inc. , Collegeville, Pennsylvania.
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Farkouh
authors.affiliation: Pfizer Inc. , Collegeville, Pennsylvania.
authors.forename: David R
authors.initials: DR
authors.lastname: Strutton
authors.affiliation: Policy Analysis Inc. , Brookline, Massachusetts.
authors.forename: John
authors.initials: J
authors.lastname: Edelsberg
keywords: Streptococcus pneumonia; comorbidity; pneumococcal infections; pneumonia