title: [Hydrogen sulfide: A promising therapy in neuroprotection following cardiac arrest?].
abstract: Each year, in France, the number of cardiac arrests is evaluated between 30,000 to 50,000. When a patient survives, he undergoes a post-resuscitation syndrome which can aggravate the injuries and for which nowadays, no medication is available. In some kinds of cardiac arrest, a hypothermia protocol can be applied with a need for monitoring because of the appearance of side effects. In this context, hydrogen sulfide, which is a gasotransmitter with numerous physiological and pharmacological properties, may be interesting. Indeed, its use could protect against oxidative, inflammatory and apoptotic troubles induced by the post-resuscitation syndrome. The implied biochemical mechanisms are adenosine triphosphate potassium channels activation and cytochrome c oxidase inhibition. This molecule can also induce a suspended animation state characterized by a metabolism decrease, which could give a delay for physicians to start a therapeutic monitoring. Thus, in spite of a modest and sometimes contradictory literature, this compound could become the first neuroprotective molecule in cardiac arrest.
authors.affiliation: EA 3452 CITHEFOR, faculté de pharmacie, université de Lorraine, 5, rue A.-Lebrun, BP 80403, 54001 Nancy cedex, France; Service de réanimation pédiatrique, hôpital d'enfants, centre hospitalo-universitaire de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: H
authors.initials: H
authors.lastname: Sayouri
authors.affiliation: EA 3452 CITHEFOR, faculté de pharmacie, université de Lorraine, 5, rue A.-Lebrun, BP 80403, 54001 Nancy cedex, France. Electronic address: ariane.boudier@univ-lorraine.fr.
authors.forename: A
authors.initials: A
authors.lastname: Boudier
authors.affiliation: EA 3452 CITHEFOR, faculté de pharmacie, université de Lorraine, 5, rue A.-Lebrun, BP 80403, 54001 Nancy cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.affiliation: EA 3452 CITHEFOR, faculté de pharmacie, université de Lorraine, 5, rue A.-Lebrun, BP 80403, 54001 Nancy cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Leroy
authors.affiliation: Service de réanimation pédiatrique, hôpital d'enfants, centre hospitalo-universitaire de Nancy, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France.
authors.forename: S
authors.initials: S
authors.lastname: Le Tacon
mesh_terms: D000818:Animals; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D006862:Hydrogen Sulfide / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000209:etiology* / Q000517:prevention & control*; D000066829:Neuroprotection; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents; D006862:Hydrogen Sulfide
keywords: Arrêt cardiorespiratoire; Cardiac arrest; Gasotransmitter; Gazotransmetteur; H(2)S; Hydrogen sulfide; Neuroprotection; Suspended animation