title: Serum salusins levels are increased and correlated positively with cyst size in ovarian endometrioma.
abstract: OBJECTIVE
  The objective of this study is to evaluate plasma concentrations of salusin-α and salusin-β levels in women with endometrioma and non-endometriotic benign ovarian cysts.
  
  
  METHODS
  Endometrioma patients (n = 14), non-endometriotic ovarian cysts (n = 14), and age-matched normal healthy fertile subjects (n = 14) participated in this study. Plasma salusin-α and salusin-β levels at the time of mid-luteal phase before and 3 months after L/S cystectomy were measured using ELISA and EIA tests, and their relation with demographic parameters was also assessed.
  
  
  RESULTS
  The mean salusin-α and salusin-β levels were significantly higher in women with endometrioma before the removal of cyst compared with cases with non-endometriotic cyst and fertile cases. Surgical removal of the endometrioma decreased the mean salusin-α and salusin-β levels to the level of those with non-endometriotic cyst before and after the cystectomy and fertile women, in both unilateral and bilateral endometrioma cases. Plasma salusin-β concentrations were found to be positively correlated with age, size of cyst, bilaterality, and salusin-α levels. Salusin-β values showed no correlations to BMI and size of the ovarian cysts.
  
  
  CONCLUSIONS
  Plasma salusin-α and salusin-β levels are increased in endometrioma patients and positively correlated with endometrioma size. Laparoscopic removal of the endometrioma by stripping technique decreases the salusin levels to a similar level of fertile women.
authors.affiliation: a Department of Obstetrics and Gynecology , Kafkas University School of Medicine , Kars , Turkey .
authors.forename: Levent
authors.initials: L
authors.lastname: Sahin
authors.affiliation: a Department of Obstetrics and Gynecology , Kafkas University School of Medicine , Kars , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: b Department of Obstetrics and Gynecology , Inonu University School of Medicine , Malatya , Turkey .
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.affiliation: c Department of Biochemistry , Behcet Uz Children Hospital , Izmir , Turkey , and.
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Çelik
authors.affiliation: d Department of Biochemistry , Firat University School of Medicine , Elazig , Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.affiliation: a Department of Obstetrics and Gynecology , Kafkas University School of Medicine , Kars , Turkey .
authors.forename: Servet
authors.initials: S
authors.lastname: Gencdal
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D010048:Ovarian Cysts / Q000097:blood* / Q000473:pathology; D010049:Ovarian Diseases / Q000097:blood* / Q000473:pathology
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C478739:TOR2A protein, human
keywords: Angiogenesis; endometriosis; infertility; ovary; salusins