title: Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases.
abstract: Epidemiological studies have led scientists to postulate the developmental origins of health and disease hypothesis for noncommunicable diseases such as diabetes, cardiovascular diseases, hypertension, and obesity. However, the cellular and molecular mechanisms involved in the development of these diseases are not well understood. In various animal models, it has been observed that oxidative stress during pregnancy is associated with the early development of endothelial dysfunction in offspring. This phenomenon suggests that endothelial dysfunction may initiate in the uterus and could lead to increased risk of cardiovascular disease later in life. Currently, it is known that many of the fetal adaptive responses to environmental factors are mediated by epigenetic changes in the genome, especially by the degree of methylation in cytosines in the promoter regions of genes. These findings suggest that the establishment of a particular epigenetic pattern in the genome may be generated by oxidative stress.
authors.affiliation: J.G. Ortega Ávila is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, Research Group on Basic and Clinical Health Sciences, School of Medicine, Pontificia Universidad Javeriana, Cali, Colombia. I. Echeverri is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, School of Medicine, Universidad ICESI, Cali, Colombia. C. Aguilar de Plata and A. Castillo are with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia. jgortega@javerianacali.edu.co.
authors.forename: Jose Guillermo Ortega
authors.initials: JG
authors.lastname: Ávila
authors.affiliation: J.G. Ortega Ávila is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, Research Group on Basic and Clinical Health Sciences, School of Medicine, Pontificia Universidad Javeriana, Cali, Colombia. I. Echeverri is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, School of Medicine, Universidad ICESI, Cali, Colombia. C. Aguilar de Plata and A. Castillo are with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Isabella
authors.initials: I
authors.lastname: Echeverri
authors.affiliation: J.G. Ortega Ávila is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, Research Group on Basic and Clinical Health Sciences, School of Medicine, Pontificia Universidad Javeriana, Cali, Colombia. I. Echeverri is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, School of Medicine, Universidad ICESI, Cali, Colombia. C. Aguilar de Plata and A. Castillo are with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Cecilia Aguilar
authors.initials: CA
authors.lastname: de Plata
authors.affiliation: J.G. Ortega Ávila is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, Research Group on Basic and Clinical Health Sciences, School of Medicine, Pontificia Universidad Javeriana, Cali, Colombia. I. Echeverri is with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia and the Department of Basic Sciences, School of Medicine, Universidad ICESI, Cali, Colombia. C. Aguilar de Plata and A. Castillo are with the Department of Physiological Sciences, Nutrition Group, School of Biomedical Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Andrés
authors.initials: A
authors.lastname: Castillo
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics*; D044127:Epigenesis, Genetic; D005260:Female; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D018384:Oxidative Stress; D011247:Pregnancy / Q000502:physiology*
keywords: cardiovascular diseases; endothelial dysfunction; epigenetics; fetal programming; oxidative stress; pregnancy