title: Comparison of different scoring systems in predicting short-term mortality after liver transplantation.
abstract: BACKGROUND
  Many scoring systems have been used in predicting the outcomes of liver transplantations. The aim of this study was to compare between 4 scoring systems-Sequential Organ Failure Assessment (SOFA), Model for End-Stage Liver Disease, Acute Physiology and Chronic Health Evaluation II, and Child Turcotte-Pugh -among patients who underwent living-donor liver transplantation (LDLT) seeking to evaluate the best system to correlate with post-operative outcomes.
  
  
  METHODS
  This study retrospectively reviewed the medical records of 53 patients who had received LDLT in a tertiary care hospital from January 2005 to December 2010. Demographic, clinical, and laboratory data were recorded. Each patient was assessed by use of 4 scoring systems before transplantation and on post-operative days 1 to 7 and at 3 months.
  
  
  RESULTS
  The overall 3-month survival rate was 64%. The pre-transplant SOFA score had the best discriminatory power; moreover, the SOFA score on post-operative day 7 had the best Youden index (.875). The survival rate at 3-month follow-up after liver transplantation differed significantly (P = .00023, highest area under the receiver operator characteristic curve = .952) between patients who had SOFA scores <8 and those had SOFA score >8 on post-liver transplant day 7. This study also demonstrated that respiratory rate (P = .017) and serum bilirubin level (P = .048) and duration of intensive care unit stay (P = .04) are significant risk factors related to early mortality after LDLT.
  
  
  CONCLUSIONS
  The pre-transplant SOFA score was a statistically significant predictor of 3-month mortality; SOFA score on post-liver transplant day 7 had the best discriminative power for predicting 3-month mortality.
authors.affiliation: Department of Internal Medicine, Cairo University, Cairo, Egypt. Electronic address: fatmagaber77@gmail.com.
authors.forename: F G
authors.initials: FG
authors.lastname: Elsayed
authors.affiliation: Department of Internal Medicine, Cairo University, Cairo, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Sholkamy
authors.affiliation: Department of General Surgery, Cairo University, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Elshazli
authors.affiliation: Department of Critical Care Medicine, Cairo University, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Elshafie
authors.affiliation: Department of Internal Medicine, Cairo University, Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Naguib
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D001663:Bilirubin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D058625:End Stage Liver Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009026:Mortality; D063305:Organ Dysfunction Scores; D011379:Prognosis; D012372:ROC Curve; D056152:Respiratory Rate; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate; D055815:Young Adult
chemical_list: D001663:Bilirubin