title: The efficacy and safety of hepatic arterial infusion of oxaliplatin plus intravenous irinotecan, leucovorin and fluorouracil in colorectal cancer with inoperable hepatic metastasis.
abstract: Hepatic arterial infusion (HAI) was evaluated for different drugs to treat hepatic metastasis from colorectal cancer (CRC). Combination treatment with 5-fluorouracil (5-FU), leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) is effective for CRC. A phase II study was conducted to evaluate concomitant HAI administration of oxaliplatin and intravenous leucovorin, 5-FU and irinotecan (FOLFIRI) for patients with inoperable liver metastasis, which had chemotherapy with oxaliplatin (OX) 85 mg/m(2) HAI plus systemic intravenous chemotherapy [leucovorin 200 mg/m(2), 5-FU 2400 mg/m(2) and irinotecan (IRI) 160 mg/m(2) in 48 hours]. We treated 24 patients. Neutropaenia was the most frequent toxicity. The main HAI-related toxicity was pain. Two patients (8%) obtained complete response and 17 patients (70%) partial response, giving an objective response rate of 78%. Median follow-up was 22.8 months, and median overall and disease-free survival times were 29 and 20 months, respectively. Therefore, OX HAI and intravenous FOLFIRI is feasible and effective in patients with metastatic CRC.
authors.affiliation: a Regional Institute of Oncology , University of Medicine and Pharmacy 'Gr.T.Popa' , Iasi , Romania.
authors.forename: Simona R
authors.initials: SR
authors.lastname: Volovat
authors.affiliation: b Center of Oncology Euroclinic , Iasi , Romania.
authors.forename: Constantin
authors.initials: C
authors.lastname: Volovat
authors.affiliation: c University of Medicine and Pharmacy Timisoara , Romania.
authors.forename: Serban M
authors.initials: SM
authors.lastname: Negru
authors.affiliation: d University Hospital 'St. Spiridon' , University of Medicine and Pharmacy 'Gr.T.Popa' , Iasi , Romania.
authors.forename: Mihai
authors.initials: M
authors.lastname: Danciu
authors.affiliation: a Regional Institute of Oncology , University of Medicine and Pharmacy 'Gr.T.Popa' , Iasi , Romania.
authors.forename: Viorel
authors.initials: V
authors.lastname: Scripcariu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002166:Camptothecin / Q000031:analogs & derivatives; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D036502:Infusions, Intralesional / Q000379:methods; D007262:Infusions, Intravenous; D053208:Kaplan-Meier Estimate; D002955:Leucovorin; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin
keywords: Chemotherapy; FOLFOXIRI; HAI; Metastatic colorectal cancer