title: [Experimental study of the basic pharmacokinetic characteristics of dipeptide carnosine and its efficiency of penetration into brain tissues].
abstract: We have used an original chromatography/mass spectrometry technique to study the pharmacokinetics of dipeptide carnosine in C57 Black/6 mice after intra-peritoneal administration of the drug at a dose of 1 g/kg. The basic pharmacokinetic characteristics of carnosine were measured the in the blood and brain. The obtained concentration-time curve has a biexponential character. It is shown that the maximum concentration of carnosine in the blood plasma is Cmax = 1081.75 ± 124.24 μg/mL and it is achieved in a time interval of Tmax = 0.25 h. We showed that i.p. administration of exogenous carnosine could significantly increase the concentration of that substance in the brain. Tissue availability of dipeptide carnosine for brain tissue is relatively good and constitutes 59% from the total amount of blood carnosine. It was found that the maximum concentration of carnosine in the brain occurs at the sixth hour after i.p. administration when the concentration of drug in the blood is minimal.
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: D A
authors.initials: DA
authors.lastname: Abaimov
authors.forename: M V
authors.initials: MV
authors.lastname: Tankevich
authors.forename: E Yu
authors.initials: EY
authors.lastname: Pantyukhova
authors.forename: D I
authors.initials: DI
authors.lastname: Prokhorov
authors.forename: T N
authors.initials: TN
authors.lastname: Fedorova
authors.forename: A V
authors.initials: AV
authors.lastname: Lopachev
authors.forename: S L
authors.initials: SL
authors.lastname: Stvolinskii
authors.forename: E V
authors.initials: EV
authors.lastname: Konovalova
authors.forename: R D
authors.initials: RD
authors.lastname: Seifulla
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002336:Carnosine / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
chemical_list: D002336:Carnosine