title: Regional Brain Biometrics at Term-Equivalent Age and Developmental Outcome in Extremely Low-Birth-Weight Infants.
abstract: OBJECTIVE
  This study aims to evaluate individual regional brain biometrics and their association with developmental outcome in extremely low-birth-weight (ELBW) infants.
  
  
  METHODS
  This is a retrospective study evaluating term-equivalent magnetic resonance imaging (TE-MRI) from 27 ELBW infants with known developmental outcomes beyond 12 months corrected age. Regional biometric measurements were performed by a pediatric neuroradiologist blinded to outcome data. Measures included biparietal width, transcerebellar diameter (TCD), deep gray matter area (DGMA), ventricular dilatation, corpus callosum, and interhemispheric distance. The relationship between regional biometrics and Bayley-II developmental scores were evaluated with linear regression models.
  
  
  RESULTS
  The study cohort had an average±standard deviation birth weight of 684±150 g, gestational age of 24.6±2 weeks and 48% males. DGMA was significantly associated with both cognitive and motor outcomes. Significant associations were also observed between TCD and corpus callosum splenium with cognitive and motor outcomes, respectively. Other biometric measures were not associated with outcome (p>0.05). DGMA<10.26 cm2 was highly specific for poor motor and cognitive outcome.
  
  
  CONCLUSIONS
  TE-MRI biometrics reflecting impaired deep gray matter, callosal, and cerebellar size is associated with worse early childhood cognitive and motor outcomes. DGMA may be the most robust single biometric measure to predict adverse developmental outcome in preterm survivors.
authors.affiliation: Divsion of Neonatology, Children's National Health Systems, Washington, District of Columbia.
authors.forename: Launice
authors.initials: L
authors.lastname: Melbourne
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Murnick
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
authors.forename: Taeun
authors.initials: T
authors.lastname: Chang
authors.affiliation: Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
authors.forename: Penny
authors.initials: P
authors.lastname: Glass
authors.affiliation: Divsion of Neonatology, Children's National Health Systems, Washington, District of Columbia.
authors.forename: An N
authors.initials: AN
authors.lastname: Massaro
mesh_terms: D001699:Biometry; D001724:Birth Weight; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies