title: Synthesis, characterization and antiamoebic activity of chalcones bearing N-substituted ethanamine tail.
abstract: A series of chalcones (4-21) possessing N-substituted ethanamine were synthesized by the aldol condensation reaction of 1-(4-(2-substituted ethoxy)phenyl)ethanones with different aldehydes preceded by the reaction of 2-chloro N-substituted ethanamine hydrochloride and 4-hydroxy acetophenone. The structure of all the synthesized compounds was elucidated by various spectral and X-ray diffraction studies. The compounds were screened against HM1: IMSS strain of Entamoeba histolytica and cytotoxicity was performed on A549 (non-small cell lung cancer cell line) cells by MTT assay. Out of eighteen compounds twelve showed better activity then the standard drug metronidazole. The compound 9, 14 and 19 showed good cell viability, hence were least toxic.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
authors.forename: Saadia
authors.initials: S
authors.lastname: Leeza Zaidi
authors.affiliation: School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Sonam
authors.initials: S
authors.lastname: Mittal
authors.affiliation: School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Maitreyi S
authors.initials: MS
authors.lastname: Rajala
authors.affiliation: Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira s/n, 15071 A Coruña, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Avecilla
authors.affiliation: Department of Biotechnology, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Husain
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: amir_sumbul@yahoo.co.in.
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
mesh_terms: D000563:Amebicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000588:Amines / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D045744:Cell Line, Tumor; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans
chemical_list: D000563:Amebicides; D000588:Amines; D047188:Chalcones
keywords: A549; Amoebiasis; Chalcones; E. histolytica; MTT assay