title: [Study on pharmacokinetics of demethoxycurcumin phospholipid complex in rats].
abstract: OBJECTIVE
  To study the pharmacokinetics of Demethoxycurcumin phospholipid complex in rats with oral administration.
  
  
  METHODS
  Drawing blood from the SD rats after oral administration Demethoxycurcumin phospholipid complex and free demethoxycurcumin. The blood concentration were determined by HPLC.
  
  
  RESULTS
  The pharmacokinetics parameter of Demethoxycurcumin phos- pholipid complex were calculated and the results were as follows: AUC0-t (693. 306 ± 128. 55) µg/(L . h),1. 96-fold increase in the area under the plasma concentration versus time curve (AUC0-t) than that of free demethoxycurcumin, and AUC0-∞ (716. 174 ± 123. 18) µg/(L - h), 1. 93-fold increase than that of free demethoxycurcumin. Cmax (95. 044 ± 6. 95) µg/L, Tmax (0. 17 ± 0) h. Conclusion:Demethoxycurcumin phospholipid complex have higher bioavailability than free demethoxycurcumin,and their preparations bioequivalence are unqualified.
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Luo
authors.forename: Xue-yuan
authors.initials: XY
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Zhang
authors.forename: Jing-qing
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D036381:Diarylheptanoids; D010743:Phospholipids / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013810:Therapeutic Equivalency
chemical_list: D036381:Diarylheptanoids; D010743:Phospholipids; D003474:Curcumin; C050229:demethoxycurcumin