title: Myeloperoxidase 463 G>A and superoxide dismutase Ala16Val gene polymorphisms in obese children.
abstract: The aim of the study was to determine the role of MnSOD Ala16Val and MPO G-463A gene polymorphisms in the pathogenesis of metabolic syndrome in obese children. A total of 97 obese children with insulin resistance and, as a control group, 96 healthy children were enrolled in the study. In the obese group, AA, AV and VV genotype frequencies of the MnSOD gene and GG, GA and AA genotype frequencies of the MPO gene were not significantly different from the frequencies found in the control group (p=0.555 and 0.530, respectively). In the obese group, children who carry both VV (for MnSOD) and GG (for MPO) alleles (n= 26) had higher HOMA-IR levels (6.51 ± 3.91 vs 5.03 ± 2.12) than those of all other genotype combinations (n=71) (p=0.013). Children who have the maximum risk of developing oxidative stress with the combination of the VV (for MnSOD) and GG (for MPO) genotypes had higher HOMA-IR levels, suggesting these polymorphisms may lead to insulin resistance.
authors.affiliation: Division of Pediatric Endocrinology, Bezmialem Vakif University,Medical Faculty,Istanbul,Turkey. drtolgaozgen@yahoo.com.
authors.forename: İlker Tolga
authors.initials: İT
authors.lastname: Özgen
authors.forename: Emel
authors.initials: E
authors.lastname: Torun
authors.forename: Arzu
authors.initials: A
authors.lastname: Ergen
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Cesur
authors.forename: Hande
authors.initials: H
authors.lastname: Karagedik
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Zeybek
authors.forename: Mehmet Şirin
authors.initials: MŞ
authors.lastname: Aksu
authors.forename: Faruk
authors.initials: F
authors.lastname: Öktem
mesh_terms: D000483:Alleles; D002648:Child; D004247:DNA / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000201:enzymology / Q000235:genetics*; D018384:Oxidative Stress / Q000235:genetics*; D009195:Peroxidase / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism
chemical_list: D004247:DNA; D009195:Peroxidase; D013482:Superoxide Dismutase