title: Additive gamma frailty models with applications to competing risks in related individuals.
abstract: Epidemiological studies of related individuals are often complicated by the fact that follow-up on the event type of interest is incomplete due to the occurrence of other events. We suggest a class of frailty models with cause-specific hazards for correlated competing events in related individuals. The frailties are based on sums of gamma distributed variables and offer closed form expressions for the observed intensities. An inference procedure with a recursive baseline estimator is proposed, and its large sample properties are established. The estimator readily handles cluster left-truncation as occurring in the Nordic twin registers. The performance in finite samples is investigated by simulations and an example on prostate cancer in twins is provided for illustration.
authors.affiliation: Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark.
authors.forename: Frank
authors.initials: F
authors.lastname: Eriksson
authors.affiliation: Section of Biostatistics, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark.
authors.forename: Thomas
authors.initials: T
authors.lastname: Scheike
mesh_terms: D003198:Computer Simulation; D015986:Confounding Factors, Epidemiologic; D015340:Epidemiologic Research Design; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D014427:Twins / Q000235:genetics*
keywords: Cause-specific hazard; Clustered; Competing risks; Gamma frailty; Survival analysis; Twin studies