title: [Reactivity of the central nervous system influences the sensitivity of secretory cells of the stomach to carbacholine and glycyl-proline (Gly-Pro)].
abstract: In experiments using cluster analysis of the behavioral activity of rats in the "open field" test, the animals were divided into three groups with different types of behavior and response to the first presentation of the test: (i) active-search (all the studied reactions are expressed), (ii) intermediate, and (iii) passive-defensive (lowest level of activity). Differences in the indices of carbacholine-stimulated gastric secretion in rats of different groups were manifested by greater secretion of the stomach and lower digestive capacity of gastric juice observed in rats with active-search and intermediate types of behavior in the "open field" test in contrast to rats with passive-defensive type. Combined administration of cholinomimetic and glycyl-proline (Gly-Pro) lead to decreased proteolytic activity of gastric juice in rats with active-search behavior in the "open field" test, decreased volume of gastric secretion in rats with an intermediate type of behavior, and increased volume of juice and its decreased digestive ability in rats with passive-defensive behavior.
authors.forename: T A
authors.initials: TA
authors.lastname: Tomova
authors.forename: T A
authors.initials: TA
authors.lastname: Zamoshchina
authors.forename: E Yu
authors.initials: EY
authors.lastname: Prosekina
authors.forename: M V
authors.initials: MV
authors.lastname: Svetlik
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology / Q000294:innervation / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D004151:Dipeptides; C015248:glycylproline; D002217:Carbachol