title: [Comparison of results of two flexible ovarian hiperestimulation protocols with two different initial doses (150 vs ≥ 225)].
abstract: BACKGROUND
  With the use of new protocols Controlled ovarian hyperstimulation (COH) with lower doses of gonadotropins to the classics protocols and current trend of fewer embryos transferred, there is no agreement until today on the optimal dose start of a COH protocol.
  
  
  OBJECTIVE
  Compare the results of two flexible protocols of HOC with different starting doses (150 vs 225 lU rFSH/hMG) plus a GnRH antagonist in cycles of IVF / ICSI.
  
  
  METHODS
  Retrospective, descriptive study, we analyzed 231 cycles of IVF/ICSI being the primary variables: total FSH dose, dose increase, retrieved oocytes, embryos available for transfer and for cryopreservation.
  
  
  RESULTS
  The total dose of FSH in group 11 was significantly higher versus group 1 (2096.0 vs 1447.9). The percentage of patients in whom the dose increased was higher in Group I vs Group 11 (26.4% vs 9.1%, p = 0.001). The number of retrieved oocytes was similar between the groups (10.5 vs 10.2, p = 0.76) as well as the number of embryos available the day of the transfer and the number of embryos that were vitrified 6.73 vs 6.08 (p = 0.97) and 1.5 and 1.3 (p=0.820) for Group I and I respectively. The clinical pregnancy rate was 39.3% (n = 91), and for groups I and 11 were 41.6 and 37.7% respectively.
  
  
  CONCLUSIONS
  No significant differences between two loading dose was found (150 vs ≥ 225) in most of the primary endpoint.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barros-Delgadillo
authors.forename: Cirenia Iveth
authors.initials: CI
authors.lastname: Ruiz-Balderrama
authors.forename: Mauricio
authors.initials: M
authors.lastname: Ríos-Barba
mesh_terms: D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage / Q000627:therapeutic use*; D054315:Oocyte Retrieval; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods
chemical_list: D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone