title: Adult-onset Alexander's disease mimicking degenerative disease.
abstract: Adult-onset Alexander's disease is a rare leukodystrophy that can present later in life in a variety of ways, often mimicking more common neurodegenerative conditions. We present two cases with novel mutations, diagnosed from their characteristic MR scan findings. Even in much older people, clinicians should have a high clinical suspicion if there are typical imaging findings.
authors.affiliation: Department of Macquarie Neurology, Macquarie University Hospital, Macquarie University, Sydney, New South Wales, Australia.
authors.forename: Omar
authors.initials: O
authors.lastname: Ahmad
authors.affiliation: Department of Macquarie Neurology, Macquarie University Hospital, Macquarie University, Sydney, New South Wales, Australia.
authors.forename: Dominic Brock
authors.initials: DB
authors.lastname: Rowe
mesh_terms: D000369:Aged, 80 and over; D038261:Alexander Disease / Q000175:diagnosis*; D001933:Brain Stem / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000503:physiopathology*
keywords: GENETICS; MRI