title: The role of intracellular calcium for the development and treatment of neuroblastoma.
abstract: Neuroblastoma is the second most common paediatric cancer. It developsfrom undifferentiated simpatico-adrenal lineage cells and is mostly sporadic; however, theaetiology behind the development of neuroblastoma is still not fully understood. Intracellularcalcium ([Ca2+]i) is a secondary messenger which regulates numerous cellular processesand, therefore, its concentration is tightly regulated. This review focuses on the role of[Ca2+]i in differentiation, apoptosis and proliferation in neuroblastoma. It describes themechanisms by which [Ca2+]i is regulated and how it modulates intracellular pathways.Furthermore, the importance of [Ca2+]i for the function of anti-cancer drugs is illuminatedin this review as [Ca2+]i could be a target to improve the outcome of anti-cancer treatmentin neuroblastoma. Overall, modulations of [Ca2+]i could be a key target to induce apoptosisin cancer cells leading to a more efficient and effective treatment of neuroblastoma.
authors.affiliation: Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, POB 24144, Doha, Qatar. noothanjyothi@yahoo.co.in.
authors.forename: Noothan Jyothi
authors.initials: NJ
authors.lastname: Satheesh
authors.affiliation: Weill Cornell Medical College in Qatar, Qatar Foundation-Education City, POB 24144, Doha, Qatar. dib2015@qatar-med.cornell.edu.
authors.forename: Dietrich
authors.initials: D
authors.lastname: Büsselberg
keywords: ALK; FAK; NGF signalling; PI3K/AKT; apoptosis; chemotherapeutic treatment; chemotherapy; differentiation; drug resistance; intracellular calcium([Ca2+]i); neuroblastoma; proliferation