title: Intracranial aneurysm in a patient with glucocorticoid-remediable aldosteronism.
abstract: Glucocorticoid-remediable aldosteronism (GRA) is an autosomal dominant disorder in which the increase in aldosterone secretion produced by Adrenocorticotropic hormone (ACTH) is no longer transient. Here we present a case of a 32-year-old man with GRA who was found to have an intracranial aneurysm following screening. His blood pressure had been well controlled and closely monitored since diagnosis and the institution of treatment at age 13 years. This is a rarely reported example of this manifestation in GRA, and both the treatment and rationale for therapy are discussed below.
authors.affiliation: a Department of Neurosurgery , Institute of Neurological Science, Southern General Hospital , Glasgow , UK.
authors.forename: Basel
authors.initials: B
authors.lastname: Al Romhain
authors.affiliation: a Department of Neurosurgery , Institute of Neurological Science, Southern General Hospital , Glasgow , UK.
authors.forename: Adam M H
authors.initials: AM
authors.lastname: Young
authors.affiliation: b Department of Neuroradiology , Institute of Neurological Science, Southern General Hospital , Glasgow , UK.
authors.forename: Jo J
authors.initials: JJ
authors.lastname: Battacharya
authors.affiliation: a Department of Neurosurgery , Institute of Neurological Science, Southern General Hospital , Glasgow , UK.
authors.forename: Nigel
authors.initials: N
authors.lastname: Suttner
mesh_terms: D000293:Adolescent; D000328:Adult; D015901:Angiography, Digital Subtraction; D003907:Dexamethasone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000188:drug therapy*; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery*; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000601:surgery; D018810:Magnetic Resonance Angiography; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology / Q000601:surgery; D064847:Multimodal Imaging
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone
keywords: aneurysm; aneurysm surgery; endovascular therapy; hypertension