title: [Inflammation and brain aging].
abstract: The review covers current concepts on cell and molecular mechanisms of neuroinflammation and aging with the special focus on the regulation of cytokine-producing activity of astroglial cells and intercellular communication. The review reflects that a key component of the aging phenomenon as a result of ineffective implementation of anti-inflammatory response are processes of the dysregulated cytokine production, in particular, an increase in the secretion of proinflammatory cytokines and an imbalance in the expression of the receptors and receptor associated proteins. Interpretation of the molecular mechanisms of cell conjugating neuroinflammation and aging cells can give rise to new therapeutic strategies that are relevant to the treatment of a wide range of central nervous system diseases and the development of new experimental models of diseases of the central nervous system.
authors.forename: A B
authors.initials: AB
authors.lastname: Salmina
authors.forename: Yu K
authors.initials: YK
authors.lastname: Komleva
authors.forename: N V
authors.initials: NV
authors.lastname: Kuvacheva
authors.forename: O L
authors.initials: OL
authors.lastname: Lopatina
authors.forename: E A
authors.initials: EA
authors.lastname: Pozhilenkova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Gorina
authors.forename: E L
authors.initials: EL
authors.lastname: Gasymly
authors.forename: Yu A
authors.initials: YA
authors.lastname: Panina
authors.forename: A V
authors.initials: AV
authors.lastname: Morgun
authors.forename: N A
authors.initials: NA
authors.lastname: Malinovskaya
mesh_terms: D001921:Brain / Q000502:physiology / Q000503:physiopathology; D002450:Cell Communication; D016922:Cellular Senescence; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*
chemical_list: D016207:Cytokines