title: Polyphenolic Constituents of the Pericarp of Mangosteen (Garcinia mangostana L.).
abstract: Three new polyphenols, together with 14 known compounds, were isolated from a hot water extract of mangosteen (Garcinia mangostana L.) pericarp, a plant that has been used medicinally in Southeast Asia. The three new polyphenols were characterized as a 4-aryl-2-flavanylbenzopyran derivative (tentatively named GM-1), 1, 3,4,3',5'-tetrahydroxy-5-methoxybenzophenone (GM-2), 2, and 2,3-dihydrochromone derivative (GM-3), 3 on the basis of NMR and MS data. The relative stereostructure of GM-1 was assigned to have 2,3-cis-3,4-trans- and 2″,3″-cis configurations on the basis of the coupling constants of heterocyclic ring protons in the (1)H NMR spectrum along with nuclear Overhauser effect correlations. The HPLC analysis indicated that major polyphenolic components in the hot water extract of mangosteen pericarp were epicatechin and procyanidin B2 (epicatechin dimer).
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University , 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
authors.forename: Morio
authors.initials: M
authors.lastname: Yoshimura
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University , 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Ninomiya
authors.affiliation: Food Development Laboratory, Nippon Shinyaku Company, Ltd. , 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Tagashira
authors.affiliation: Food Development Laboratory, Nippon Shinyaku Company, Ltd. , 14 Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Maejima
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University , 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: College of Pharmaceutical Sciences, Matsuyama University , 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Amakura
mesh_terms: D005638:Fruit / Q000737:chemistry*; D029762:Garcinia mangostana / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols
keywords: Garcinia mangostana; mangosteen; pericarp; polyphenols; procyanidin