title: One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines.
abstract: A green one-pot four-component strategy has been developed for the synthesis of [1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives using an amine, 2,2,6-trimethyl-4H-1,3-dioxin-4-one, an aldehyde, and 3-amino-1,2,4-triazole in the presence of a catalytic amount of p-toluenesulfonic acid in water within 4-6 h.
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran. a-shaabani@sbu.ac.ir.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Shaabani
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Mozhdeh
authors.initials: M
authors.lastname: Seyyedhamzeh
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Nasim
authors.initials: N
authors.lastname: Ganji
authors.affiliation: Faculty of Chemistry, Shahid Beheshti University, G. C, P. O. Box 19396-4716, Tehran, Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Hamidzad Sangachin
authors.affiliation: Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 3 Research Link, Singapore, 117602, Singapore.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Armaghan
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D014230:Triazoles; D001569:Benzodiazepines
keywords: Green chemistry; MCRs; Multicomponent reaction; Triazolopyrimidine; Water