title: Multidrug-resistant Pseudomonas aeruginosa endophthalmitis in a silicone oil-filled eye treated with piperacillin/tazobactam: report of a case and review of literature.
abstract: The incidence of endophthalmitis after pars plana vitrectomy is low. Silicone oil is a tamponading agent which has anti-microbial activity. Post-operative endophthalmitis following vitrectomy with silicone oil tamponade has been rarely reported. We describe the case of a young male who underwent pars plana vitrectomy with silicone oil for retinal detachment with a giant retinal tear. He developed a clinical picture suggestive of endophthalmitis on the first post-operative day, and vitreous culture grew multidrug-resistant Pseudomonas aeruginosa. He was treated with intravitreal piperacillin/tazobactam, along with appropriate surgical management. This was followed by resolution of the infection with a remarkable improvement in visual acuity. This is the first case of multidrug-resistant Pseudomonas aeruginosa endophthalmitis following pars plana vitrectomy with silicone oil treated successfully with piperacillin/tazobactam.
authors.affiliation: ICARE Eye Hospital and Postgraduate Institute, Noida, Uttar Pradesh, India, nehadoc@hotmail.com.
authors.forename: Neha
authors.initials: N
authors.lastname: Goel
authors.forename: Vishaal
authors.initials: V
authors.lastname: Bhambhwani
authors.forename: Basudeb
authors.initials: B
authors.lastname: Ghosh
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D011183:Postoperative Complications / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012163:Retinal Detachment / Q000601:surgery; D012167:Retinal Perforations / Q000601:surgery; D012827:Silicone Oils / Q000627:therapeutic use; D014792:Visual Acuity; D014821:Vitrectomy / Q000009:adverse effects / Q000379:methods; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D012827:Silicone Oils; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin