title: The ACACB gene rs2268388 polymorphism is associated with nephropathy in Caucasian patients with diabetes: a meta-analysis.
abstract: To date, case-control studies on the association between a single-nucleotide polymorphism (SNP), rs2268388, in the acetyl-coenzyme A carboxylase beta (ACACB) gene and diabetic nephropathy have provided controversial results. To clarify the effect of rs2268388 on the risk of diabetic nephropathy, a meta-analysis of all case-control studies was performed. The fixed effects and random effects models showed that the C allele was associated with a decreased susceptibility risk of diabetic nephropathy compared with the T allele among Caucasian patients with diabetes. The contrast of the recessive model produced the same pattern of results as the allele contrast. Our pooled data suggest a significant association exists between rs2268388 and diabetic nephropathy among Caucasian patients with diabetes.
authors.affiliation: a Department of Gerontology , The Affiliated ZhongDa Hospital of Southeast University , Nanjing , China .
authors.forename: Li
authors.initials: L
authors.lastname: An
authors.affiliation: b Department of Internal Medicine , The Second Affiliated Hospital of Southeast University , Nanjing , China , and.
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.affiliation: c Institute of Nephrology, ZhongDa Hospital, School of Medicine, Southeast University , Nanjing , China.
authors.forename: Ri-Ning
authors.initials: RN
authors.lastname: Tang
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis; D003928:Diabetic Nephropathies / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D006801:Humans; D015994:Incidence; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D018570:Risk Assessment; D044465:White People / Q000235:genetics
chemical_list: C520105:ACACB protein, human; D000103:Acetyl-CoA Carboxylase
keywords: ACACB; diabetic nephropathy; meta-analysis; polymorphism; susceptibility