title: Prolidase activity in chronic plaque psoriasis patients.
abstract: BACKGROUND
  Psoriasis is a chronic, inflammatory, T-cell-mediated and hyperproliferative skin disease characterized by erythematous, squamous, sharply circumscribed and infiltrated plaques. The metabolisms of the collagen proteins undergo considerable changes due to the acceleration of their turnovers as a result of increased prolidase activity in psoriasis patients.
  
  
  OBJECTIVE
  To determine the level of prolidase activity in psoriasis patients and evaluate its relationship with the oxidative system.
  
  
  METHODS
  The serum prolidase enzyme activity, total antioxidant levels and total oxidant levels of 40 psoriasis patients and a control group including 47 healthy individuals were analyzed by using their serum samples, and their oxidative stress indices were calculated.
  
  
  RESULTS
  The prolidase levels (p < 0.01), total oxidant levels (p < 0.01) and oxidative stress index levels (p < 0.001) of the patient group were higher than the corresponding parameters in the control group. The total antioxidant level was low (p < 0.01). Although a positive correlation was found between the prolidase and total antioxidant levels and the total oxidant level, no correlation was found between prolidase and the oxidative stress index.
  
  
  CONCLUSIONS
  It has been determined that the activity of the prolidase enzyme increases due to the increased collage turnover in psoriasis patients. Increased serum oxidant levels and oxidative stress indices values may play a role in the pathogenesis of psoriasis.
authors.affiliation: Department of Dermatology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hacer Altın
authors.initials: HA
authors.lastname: Sürücü
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Department of Dermatology, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozgöztas
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.affiliation: Department of Dermatology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yesilova
authors.affiliation: Department of Dermatology, Harran University School of Medicine, Sanliurfa, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Turan
keywords: oxidative stress index; prolidase; psoriasis disease