title: [Molecular-genetic mechanisms of cornea morphogenesis].
abstract: In this paper, we analyzed our own results and published data on the expression of regulatory genes encoding transcription factors Pax6/PAX6, Pitx2/PITX2, Fox1/FOXC1, Prox1/PROX1, Oct4/OCT4, Nanog/NANOG, and TGFβ2 signaling protein during morphogenesis of the cornea in vertebrates. We considered the results obtained for the cornea of model animals, primarily mice, and human fetal cornea. The main possibility of establishing common mechanisms of eye development in vertebrates in health and disease is comparative studies of eye morphogenesis of humans and animal models.
authors.forename: I G
authors.initials: IG
authors.lastname: Panova
authors.forename: Yu V
authors.initials: YV
authors.lastname: Markitantova
authors.forename: Yu A
authors.initials: YA
authors.lastname: Smirnova
authors.forename: R D
authors.initials: RD
authors.lastname: Zinovieva
mesh_terms: D000818:Animals; D003315:Cornea / Q000196:embryology* / Q000254:growth & development* / Q000502:physiology; D005136:Eye Proteins / Q000235:genetics; D051858:Forkhead Transcription Factors / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D051379:Mice; D009024:Morphogenesis / Q000235:genetics; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D053781:Transforming Growth Factor beta2 / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics; D014714:Vertebrates / Q000235:genetics / Q000254:growth & development; D000097577:Homeobox Protein PITX2; D000098551:Prospero-Related Homeobox 1 Protein
chemical_list: D005136:Eye Proteins; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; D000071317:Nanog Homeobox Protein; D050814:Octamer Transcription Factor-3; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D053781:Transforming Growth Factor beta2; D025521:Tumor Suppressor Proteins; D000097577:Homeobox Protein PITX2; D000098551:Prospero-Related Homeobox 1 Protein; C112743:FOXC1 protein, human; C486780:NANOG protein, human; C000605730:PAX6 protein, human; C494173:POU5F1 protein, human; C000605732:Pax6 protein, mouse