title: Dose finding of 3'deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose.
abstract: The aim of this study was to evaluate the therapeutic efficacy and safety of using 3'deoxyadenosine (Cordycepin - adenosine analogue) combined with deoxycoformycin (Pentostatin - an adenosine deaminase inhibitor) in mice infected with Trypanosoma evansi. We show that the combination of Cordycepin (2.0 mg kg(-1)) and Pentostatin (0.2, 0.5, 1.0, 2.0 mg kg(1)) is effective in the clearance of T. evansi, although at the higher concentrations of Pentostatin 2 mg kg(-1) some toxicity was observed in the liver and kidney. Since the Cordycepin 2.0 mg kg(-1) and Pentostatin 0.2 mg kg(-1) combination was effective and had low toxicity, we recommend this as a therapeutic option for a T. evansi mouse model.
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil. Electronic address: lucianadallarosa@gmail.com.
authors.forename: Luciana
authors.initials: L
authors.lastname: Dalla Rosa
authors.affiliation: Universidade do Estado de Santa Catarina - UDESC, Brazil.
authors.forename: Aleksandro S
authors.initials: AS
authors.lastname: Da Silva
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Camila B
authors.initials: CB
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Lucas T
authors.initials: LT
authors.lastname: Gressler
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Arnold
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Matheus D
authors.initials: MD
authors.lastname: Baldissera
authors.affiliation: Centro Universitário Franciscano - UNIFRA, Brazil.
authors.forename: Michele
authors.initials: M
authors.lastname: Sagrillo
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Manuela
authors.initials: M
authors.lastname: Sangoi
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Moresco
authors.affiliation: Instituto Federal Catarinense - IFC, Brazil.
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Mendes
authors.affiliation: Universidade do Estado de Santa Catarina - UDESC, Brazil.
authors.forename: Paulo E
authors.initials: PE
authors.lastname: Weiss
authors.affiliation: Universidade do Estado de Santa Catarina - UDESC, Brazil.
authors.forename: Luiz C
authors.initials: LC
authors.lastname: Miletti
authors.affiliation: Universidade Federal de Santa Maria - UFSM, Brazil. Electronic address: sgmonteiro@uol.com.br.
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Monteiro
mesh_terms: D000818:Animals; D003839:Deoxyadenosines / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D015649:Pentostatin / Q000008:administration & dosage*; D014344:Trypanocidal Agents / Q000008:administration & dosage*; D014345:Trypanosoma / Q000187:drug effects* / Q000502:physiology; D014352:Trypanosomiasis / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D003839:Deoxyadenosines; D014344:Trypanocidal Agents; D015649:Pentostatin; C058120:cordycepin
keywords: Adenosine; Cordycepin; Pentostatin; Toxicity; Trypanosomiasis