title: Removal of pain-relieving drugs from aqueous solutions using Octolig and selected metalloligs.
abstract: The possibility of removing certain pharmaceuticals (acetaminophen and naproxen) from water was tested using Octolig, a commercially available material with polyethylenediimine moieties covalently attached to high-surface area silica gel. In addition, the efficacy of two transition metals (cupric and ferric) derivatives of Octolig was tested. Previously amoxicillin had been successfully subjected to column chromatography for removal by means of ion encapsulation, the effectiveness of which would depend upon having appropriate anionic functional groups. Both pharmaceuticals were removed by passage over Octolig columns, though with less effectiveness than was achieved previously with xanthenylbenzenes or selected food dyes. Somewhat greater removal, ca 90%, was achieved using Cuprilig, the copper(II) derivative, but not with Ferrilig the iron(III) derivative, perhaps because the hydroxide counter ion was more closely associated with the transition metal ion and was not available to assist in proton removal.
authors.affiliation: a Department of Chemistry , University of South Florida , Tampa , Florida , USA.
authors.forename: Dean F
authors.initials: DF
authors.lastname: Martin
authors.forename: Tanya
authors.initials: T
authors.lastname: Sehgal
authors.forename: Tarah A
authors.initials: TA
authors.lastname: Word
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000737:chemistry; D000838:Anions / Q000737:chemistry; D002845:Chromatography / Q000379:methods; D003300:Copper / Q000737:chemistry*; D052918:Environmental Restoration and Remediation / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry*; D009288:Naproxen / Q000032:analysis* / Q000737:chemistry; D058428:Silica Gel / Q000737:chemistry; D012996:Solutions / Q000737:chemistry*; D014481:United States; D014874:Water Pollutants, Chemical / Q000737:chemistry*
chemical_list: D000838:Anions; D005290:Ferric Compounds; D012996:Solutions; D014874:Water Pollutants, Chemical; D000082:Acetaminophen; D009288:Naproxen; D058428:Silica Gel; D003300:Copper
keywords: Acetaminophen; Octolig; hospitals; metalloligs; naproxen; pharmaceuticals; remediation