title: Long-term follow-up of long and flat bone eosinophilic granulomas managed only with biopsy.
abstract: OBJECTIVE
  We evaluated long-term clinical and radiological follow-up results of patients with long and flat bone eosinophilic granulomas managed only with biopsy.
  
  
  METHODS
  Seventeen patients [11 male, 6 female; average age 8.5 years (range: 3.5 to 14 years)] with long and flat bone eosinophilic granulomas were followed after biopsy. Involved bones were femur (5), tibia (3), humerus (2), ulna (1), pelvis (3), scapula (1) and clavicle (1). After confirmation of diagnosis by biopsy, no further surgical intervention was performed. Clinical follow-up was done with preoperative and postoperative MSTS and VAS scores. The healing process was followed with periodic radiographs. Limb-length discrepancy, deformity, and lesion progression or recurrence were recorded. Average follow-up was 65 months (range: 28 to 115 months).
  
  
  RESULTS
  Average preoperative MSTS score was 45% (range: 30 to 56.6%), while postoperative 6, 12 and 24 months scores were measured as 76% (range: 70 to 83.3%), 88% (range: 73.3 to 93.3%) and 94% (range: 86.6 to 100%) respectively. Average VAS score, which was 8.4 (range: 6 to 10) preoperatively, had a tendency to decrease postoperatively, and was measured as 3.5 (range: 2 to 5), 2.2 (range: 1 to 3.5) and 1.1 (range: 0 to 2) at 3, 6, and 12 months. Even though the majority of lesions demonstrated complete radiographic healing at 12 months, the healing process extended to 24 months for flat bones. No patients experienced limb-length discrepancy or deformity. All lesions regressed following biopsy and no recurrence was seen.
  
  
  CONCLUSIONS
  Eosinophilic granuloma has a spontaneous healing potential, and confirming the diagnosis by biopsy is sufficient to obtain good functional and radiological results without any further intervention.
authors.affiliation: Marmara University, Pendik Training and Research Hospital, Department of Orthopaedics and Traumatology, İstanbul, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Erol
authors.affiliation: Marmara University, Pendik Training and Research Hospital, Department of Orthopaedics and Traumatology, İstanbul, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Sofulu
authors.affiliation: Marmara University, Pendik Training and Research Hospital, Department of Orthopaedics and Traumatology, İstanbul, Turkey.
authors.forename: Mert Osman
authors.initials: MO
authors.lastname: Topkar
authors.affiliation: Marmara University, Pendik Training and Research Hospital, Department of Orthopaedics and Traumatology, İstanbul, Turkey.
authors.forename: Emrah
authors.initials: E
authors.lastname: Çalışkan
authors.affiliation: Marmara University, Pendik Training and Research Hospital, Department of Pathology, İstanbul, Turkey.
authors.forename: Hüseyin Kemal
authors.initials: HK
authors.lastname: Türköz
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D002968:Clavicle / Q000473:pathology; D018450:Disease Progression; D004803:Eosinophilic Granuloma / Q000473:pathology*; D005260:Female; D005269:Femur / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000473:pathology; D008297:Male; D010384:Pelvic Bones / Q000473:pathology; D012189:Retrospective Studies; D012540:Scapula / Q000473:pathology; D013977:Tibia / Q000473:pathology; D013997:Time Factors; D014457:Ulna / Q000473:pathology