title: A Polymeric Bowl for Multi-Agent Delivery.
abstract: This paper describes a simple system for multi-agent delivery. The system consists of a biodegradable polymer particle with a hollow interior, together with a hole on its surface that can be completely or partially sealed via thermal annealing. A hydrophobic dye, Nile-red, entrapped within the shell of hollow particles presents a sustained release behavior while methylene blue, a hydrophilic model agent, encapsulated in the hollow interior shows a fast release manner. The release profiles of the probes can be further independently controlled by encapsulating methylene blue-loaded polymer nanoparticles, instead of free dye, in the hollow particle with a small hole on its surface.
authors.affiliation: Department of Polymer Science, Kyungpook National University, 1370, Sankyuk-dong, Daegu, Korea.
authors.forename: Dong Choon
authors.initials: DC
authors.lastname: Hyun
mesh_terms: D063566:Biodegradable Plastics / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D010078:Oxazines / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D063566:Biodegradable Plastics; D010078:Oxazines; D011108:Polymers; C044808:nile red
keywords: combined therapy; controlled release; hollow particles; multi-agent delivery