title: Plasma antioxidant status and motor features in de novo Chinese Parkinson's disease patients.
abstract: OBJECTIVE
  This study aimed to explore plasma antioxidant status in de novo Chinese Parkinson's disease (PD) patients and investigate its relationship with specific motor features of PD.
  
  
  METHODS
  Sixty-four de novo Chinese PD patients and 40 age- and sex-matched healthy controls were recruited. Each motor feature of PD patients was assessed by unified Parkinson's disease rating scale. Plasma antioxidant status, including plasma level of glutathione (GSH) and plasma activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), was detected using enzyme-linked immunosorbent assay. The relationship between the plasma antioxidant status and motor features of PD was evaluated by Spearman's coefficient.
  
  
  RESULTS
  Plasma GSH level and plasma activities of GSH-Px, CAT and SOD of PD patients were lower than those of healthy controls. Moreover, the declining activity of plasma CAT was related with the increasing mean postural instability and gait disorder (PIGD) score and growing age. In contrast, the severity of tremor was positively correlated with plasma SOD activity.
  
  
  CONCLUSIONS
  Our study demonstrates that the plasma antioxidant status is impaired in de novo Chinese PD patients. The complex relationship between the plasma antioxidant status and different motor features indicates that the antioxidant mechanisms underlying tremor and PIGD of PD may be different.
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Tong
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Siming
authors.initials: S
authors.lastname: Jiang
authors.affiliation: b Department of Neurology , Jiangsu Shengze Hospital , Wujiang , China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: c Department of Neurosurgery , Nanjing Children's Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: d Clinical Research Center , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Qinrong
authors.initials: Q
authors.lastname: Xu
authors.affiliation: e Department of Laboratory Medicine , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Daqian
authors.initials: D
authors.lastname: Li
authors.affiliation: f Department of Microbiology and Immunology , Nanjing Medical University , Nanjing , China.
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.affiliation: a Department of Neurology , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.
authors.forename: Kezhong
authors.initials: K
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood* / Q000503:physiopathology*
chemical_list: D000975:Antioxidants
keywords: PIGD; Parkinson's disease; oxidative stress; plasma; tremor