title: Effects of Microglia on Neurogenesis.
abstract: This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis.
authors.affiliation: Division of Pharmacology, Laboratory of Neuropharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo, 158-8501, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology; D006801:Humans; D017628:Microglia / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology*; D055153:Stem Cell Niche / Q000502:physiology
keywords: cytokine; microglia; neurogenesis; subgranular zone; subventricular zone