title: Regioselectivity switch in chiral amine-catalysed asymmetric addition of aldehydes to reactive enals.
abstract: In this communication, we present a regioselectivity switch for the chiral amine-catalysed asymmetric addition of aldehydes to reactive enals to afford either aldol adducts or conjugate adducts in a stereoselective fashion. The unprecedented asymmetric aldol reaction of aldehydes with enals was realized by the use of a diarylprolinol catalyst, giving synthetically useful and important chiral allylic alcohols.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan. maruoka@kuchem.kyoto-u.ac.jp.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kano
authors.forename: Hiroki
authors.initials: H
authors.lastname: Maruyama
authors.forename: Ryu
authors.initials: R
authors.lastname: Sakamoto
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka