title: Relationship between refractive error and ocular biometrics in twin children: the Guangzhou Twin Eye Study.
abstract: OBJECTIVE
  A cross-sectional study was conducted to explore the relationship between refractive error and ocular biometrics in children from the Guangzhou twin eye study.
  
  
  METHODS
  Twin participants aged 7-15 years were selected from Guangzhou Twin Eye Study. Ocular examinations included visual acuity measurement, ocular motility evaluation, autorefraction under cycloplegia, and anterior segment, media, and fundus examination. Axial length (AL), anterior chamber depth (ACD), and corneal curvature radius were measured using partial coherence laser interferometry. A multivariate linear regression model was used for statistical analysis.
  
  
  RESULTS
  Twin children from Guangzhou city showed a decreased spherical equivalent with age, whereas both AL and ACD were increased and corneal curvature radius remained unchanged. When adjusted by age and gender, the data from 77% of twins presenting with spherical equivalent changes indicated that these were caused by predictable variables (R2 = 0.77, P < 0.001). Primary factors affecting children's refraction included axial length (β = -0.97,P < 0.001), ACD (β = 0.33, P < 0.001), and curvature radius (β = 2.10, P < 0.001). Girls had a higher tendency for myopic status than did boys (β = -0.26, P < 0.001). Age exerted no effect upon the changes in refraction (β = -0.01, P = 0.25).
  
  
  CONCLUSIONS
  Refraction is correlated with ocular biometrics. Refractive status is largely determined by axial length as the major factor.
authors.forename: Decai
authors.initials: D
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Shengsong
authors.initials: S
authors.lastname: Huang
authors.forename: Wenyong
authors.initials: W
authors.lastname: Huang
authors.forename: Mingguang
authors.initials: M
authors.lastname: He
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001699:Biometry; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007368:Interferometry / Q000379:methods; D007834:Lasers; D008297:Male; D009216:Myopia / Q000175:diagnosis / Q000209:etiology; D012030:Refractive Errors / Q000175:diagnosis* / Q000209:etiology; D012737:Sex Factors; D014792:Visual Acuity