title: Prevalence and Genetic Analysis of Bitter Taste Perception for Phenylthiocarbamide (PTC) Among Some Muslim Populations of Uttar Pradesh, India.
abstract: BACKGROUND
  The ability to taste Phenylthiocarbamide (PTC), a bitter organic compound, described as a bimodal autosomal trait is widely used to know the heritable trait in both genetic and anthropological studies. The present study was carried out to analyze the prevalence of PTC taste sensitivity and to determine the gene frequencies among some Muslim populations of Uttar Pradesh, India. This study has some physiological relevance to highlight the adaptability of endogamous groups to behavioral traits in the same place.
  
  
  METHODS
  Unrelated, healthy individuals of both sexes (Male-403, Female-418) belonging to different populations of Uttar Pradesh, India were randomly selected with the age range of 16-45 years observed for phenylthiocarbamide to taste sensitivity. PTC tasting ability was measured by using a serial dilution method of Harris and Kalmus.
  
  
  RESULTS
  The phenotypic frequency of tasters was higher as compared to non-tasters, and the same is statistically significant (χ(2)= 11.92, df = 5, P = 0.036). There were more females among tasters (67.94%) than males (64.76%). This observation was statistically significant (χ(2) = 14.79, df = 5, P = 0.011).
  
  
  CONCLUSIONS
  The frequency of PTC tasters is greater than non-tasters and the females have lower non-taster pheno-types as compared to males. This type of study will provide background information about genetic structure of population and serves as useful interaction of genetics, food preferences and dietary patterns.
authors.affiliation: Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India.
authors.forename: Ruqaiya
authors.initials: R
authors.lastname: Hussain
authors.affiliation: Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India.
authors.forename: Ahsana
authors.initials: A
authors.lastname: Shah
authors.affiliation: Human Genetics and Toxicology Tab, Section of Genetics, Department of Zoology, Aligarh Muslim University , Aligarh, Uttar Pradesh, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Afzal
keywords: Gene frequency; Indian Muslims; Phenylthiocarbamide (PTC); Serial dilution method; Threshold distribution