title: Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation.
abstract: Stimuli-responsive materials enabling the behavior of the cells that reside within them to be controlled are vital for the development of instructive tissue scaffolds for tissue engineering. Herein, we describe the preparation of conductive silk foam-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells (HMSCs) to enhance their differentiation toward osteogenic outcomes.
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. johnhardyuk@gmail.com.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. johnhardyuk@gmail.com.|Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. johnhardyuk@gmail.com.
authors.forename: John G
authors.initials: JG
authors.lastname: Hardy
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: Sydney A
authors.initials: SA
authors.lastname: Geissler
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: David
authors.initials: D
authors.lastname: Aguilar
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Villancio-Wolter
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Mouser
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: Rushi C
authors.initials: RC
authors.lastname: Sukhavasi
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: R Chase
authors.initials: RC
authors.lastname: Cornelison
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
authors.forename: Lee W
authors.initials: LW
authors.lastname: Tien
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
authors.forename: R Carmen
authors.initials: RC
authors.lastname: Preda
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Hayden
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Chow
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Nguy
authors.affiliation: Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. david.kaplan@tufts.edu.
authors.forename: David L
authors.initials: DL
authors.lastname: Kaplan
authors.affiliation: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. schmidt@bme.ufl.edu.|Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. schmidt@bme.ufl.edu.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Schmidt
mesh_terms: D018786:Bone Substitutes / Q000737:chemistry*; D002454:Cell Differentiation; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D010012:Osteogenesis; D047011:Silk / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D047011:Silk
keywords: bone; conducting polymers; electrical stimulation; silk; stem cells