title: Cardiac and vascular toxicities of angiogenesis inhibitors: The other side of the coin.
abstract: Angiogenesis is one of the best-described tumor hallmarks. Targeting angiogenesis is becoming a successful strategy to suppress cancer growth. Vascular endothelial growth factor (VEGF), the fulcrum of angiogenesis, contributes to vascular and cardiac homeostasis. Angiogenesis inhibitors classically associated with vascular side effects are increasingly recognized for cardiac adverse effects as reflected by several meta-analyses. A global approach to these findings is a pressing need, and future strategies involving collaboration among different medical specialties are highly encouraged.
authors.affiliation: Division of Hematology and Oncology, American University of Beirut, Beirut, Lebanon.
authors.forename: Raafat S
authors.initials: RS
authors.lastname: Alameddine
authors.affiliation: Division of Cardiology, University of Rostock, Rostock, Germany.
authors.forename: Ahmad Sharif
authors.initials: AS
authors.lastname: Yakan
authors.affiliation: Division of Cardiology, American University of Beirut, Beirut, Lebanon.
authors.forename: Hadi
authors.initials: H
authors.lastname: Skouri
authors.affiliation: Division of Hematology and Oncology, American University of Beirut, Beirut, Lebanon.
authors.forename: Deborah
authors.initials: D
authors.lastname: Mukherji
authors.affiliation: Division of Hematology and Oncology, American University of Beirut, Beirut, Lebanon.
authors.forename: Sally
authors.initials: S
authors.lastname: Temraz
authors.affiliation: Division of Hematology and Oncology, American University of Beirut, Beirut, Lebanon. Electronic address: as04@aub.edu.lb.
authors.forename: Ali
authors.initials: A
authors.lastname: Shamseddine
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; Cardiac adverse effect; Pathogenesis; Vascular adverse effect