title: Serological Evidence and Risk Factors for Swine Influenza Infections among Chinese Swine Workers in Guangdong Province.
abstract: During July to September 2014, we performed a controlled, cross-sectional, seroepidemiologic study among 203 swine workers and 115 control subjects in Guangdong Province. Sera were tested using a hemagglutination inhibition assay against locally-isolated swine H3N2 and H1N1 viruses and commercially-obtained human influenza viral antigens. We found swine workers had a greater prevalence and odds of seropositivity against the swine H3N2 virus (17.3% vs. 7.0%; adjusted OR, 3.4; 95% CI, 1.1 -10.7). Younger age, self-report of a respiratory illness during the last 12 months, and seropositivity against seasonal H3N2 virus were identified as significant risk factors for seropositivity against swine H3N2 virus. As swine workers in China may be exposed to novel influenza viruses, it seems prudent for China to conduct special surveillance for such viruses among them. It also seems wise to offer such workers seasonal influenza vaccines with a goal to reduce cross-species influenza virus transmission.
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Ma
authors.affiliation: Infectious Diseases Division, Global Health Institute, Duke University, Durham, North Carolina, United States of America.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Anderson
authors.affiliation: Zhongshan Center for Disease Control and Prevention, Zhongshan, Guangdong Province, China; Zhongshan Institute, School of Public Health, Sun Yat-sen University, Zhongshan, Guangdong Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Guangzhou Baiyun Center for Disease Control and Prevention, Guangzhou, Guangdong Province, China.
authors.forename: Yingan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong Province, China; Key Laboratory for Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong Province, China.
authors.forename: Dingmei
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Infectious Diseases Division, Global Health Institute, Duke University, Durham, North Carolina, United States of America.
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Gray
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong Province, China; Zhongshan Institute, School of Public Health, Sun Yat-sen University, Zhongshan, Guangdong Province, China; Key Laboratory for Tropical Disease Control, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong Province, China.
authors.forename: Jiahai
authors.initials: J
authors.lastname: Lu
mesh_terms: D000328:Adult; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006385:Hemagglutination Inhibition Tests / Q000379:methods; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013552:Swine / Q000276:immunology* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines