title: [The effect of ligustrazin in intestinal ischemia reperfusion injury generated on rats].
abstract: BACKGROUND
  Intestinal ischemia is a serious and common clinical status. It develops as result of superior mesenteric artery (SMA) obstruction caused by many etiologic factors. Sepsis and multiple organ failure could develop following intestinal ischemia. The present study aimed to investigate the effects of ligustrazin, which has a vasodilator impact on intestinal ischemia.
  
  
  METHODS
  Forty male Wistar rats were divided into three groups randomly. Sham operation was performed on Group S (n=7); mesenteric ischemia and then 60 minutes reperfusion of the intestine process was performed on Group MI (n=7); mesenteric ischemia and then 60 minutes reperfusion of the intestine process was performed and 80 mg/kg ligustrazin was administrated intraperitoneally on Group MI+L (n=7). Intestinal tissue samples were taken for tissue MDA, SDO and nitric oxide (NO) levels, and ileum and jejunum samples were taken for histopathologic examination.
  
  
  RESULTS
  Tissue MDA levels and tissue NO levels of Group MI-L was determined to have significantly decreased. Tissue SOD levels were found similar to Group S. Chiu classification score of the jejunum and ileum was determined to have decreased in Group MI-L compared to Group MI.
  
  
  CONCLUSIONS
  As a result of this study, Ligustrazin was found to adjust lipid peroxidation in biochemical parameters during mesenteric I-R and decrease the severity of damage of I-R on the histopathological scores of the jejunum and ileum.
authors.affiliation: Department of General Surgery, Bingol Karliova State Hospital, Bingöl, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Polat
authors.affiliation: Department of General Surgery, Sivrihisar State Hospital, Eskişehir, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Türk
authors.affiliation: Department of General Surgery, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
authors.forename: Bekir
authors.initials: B
authors.lastname: Yaşar
authors.affiliation: Department of Histology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Uysal
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007082:Ileum / Q000098:blood supply*; D007583:Jejunum / Q000098:blood supply*; D008297:Male; D065666:Mesenteric Ischemia / Q000188:drug therapy*; D011719:Pyrazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D011719:Pyrazines; D014665:Vasodilator Agents; C017953:tetramethylpyrazine