title: Recent developments and applications of the Cadiot-Chodkiewicz reaction.
abstract: The classical heterocoupling of a 1-haloalkyne with a terminal alkyne catalyzed by copper salts in the presence of a base for the synthesis of unsymmetrical diynes is termed the Cadiot-Chodkiewicz coupling reaction. The diynes are of great importance due to their biological, optical and electronic properties. A number of modifications have been developed recently to improve the efficiency of Cadiot-Chodkiewicz coupling reactions in terms of selectivity and yield. This is the first review on the Cadiot-Chodkiewicz cross-coupling reaction which highlights the modern approaches and protocols developed for the synthesis and applications of unsymmetrical 1,3-diynes.
authors.affiliation: School of Chemical Sciences, Mahatma Gandhi University, PD Hills P O., Kottayam, 686 560, India. anilgi1@yahoo.com.
authors.forename: K S
authors.initials: KS
authors.lastname: Sindhu
authors.forename: Amrutha P
authors.initials: AP
authors.lastname: Thankachan
authors.forename: P S
authors.initials: PS
authors.lastname: Sajitha
authors.forename: Gopinathan
authors.initials: G
authors.lastname: Anilkumar