title: BAG-S53P4 as an additive to bone allografts: A laboratory study using an uniaxial compression test.
abstract: We want to address the clinical issue of too sparse supply of allograft in total hip replacement and ambitions of controlling the grain size distribution. Bioglass BAG-S53P4 was evaluated as a bone graft additive to chemically treated allografts with controlled grain size distribution. Allografts were chemically cleaned (CG) and mixed with BAG-S53P4 additive (BG) for comparison. All samples were compacted with a dropped weight apparatus and then underwent a uniaxial compression test. The yield limit was determined by a uniaxial compression test and density was recorded while flowability was calculated. There was no difference between the yield stress limit of BG and CG after compaction (p=0.432). Adding BAG-S53P4 reduced flowability and could indicate better interlocking mechanism between particles. Adding BAG-S53P4 seems to have no impact on the yield stress limit. The extended allografts withstand the compaction equally good which makes it a valid bone substitute in total hip replacement. An in vivo loaded study is needed before clinical use can be recommended.
authors.affiliation: Department of Orthopaedics - Experimental Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: David
authors.initials: D
authors.lastname: Putzer
authors.affiliation: Department of Orthopaedics - Experimental Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Department of Orthopaedics - Experimental Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: Débora
authors.initials: D
authors.lastname: Coraça-Huber
authors.affiliation: Department of Orthopaedics - Experimental Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: Ammann
authors.initials: A
authors.lastname: Christoph
authors.affiliation: Department of Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Liebensteiner
authors.affiliation: Department of Orthopaedics - Experimental Orthopaedics, Medical University of Innsbruck, Innrain 36, 6020, Innsbruck, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Nogler
mesh_terms: D064591:Allografts; D019644:Arthroplasty, Replacement, Hip; D018786:Bone Substitutes; D016025:Bone Transplantation; D002516:Ceramics / Q000737:chemistry*; D019245:Compressive Strength; D005270:Femur Head / Q000473:pathology*; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D010316:Particle Size; D011312:Pressure; D013314:Stress, Mechanical; D014184:Transplantation, Homologous
chemical_list: C022107:Bioglass; D018786:Bone Substitutes; C403922:bioactive glass S53P4
keywords: BAG-S53P4; additive to bone allografts; bioglass; bone graft extender; bone impaction grafting