title: Metallacrowns as products of the aqueous medium self-assembly of histidinehydroxamic acid-containing polypeptides.
abstract: Self-assembly is a widely studied, spontaneous, and reversible phenomenon leading to the formation of the ordered structures by non-covalent specific interactions among starting molecules. In this work, a new template for the self-assembly of polypeptides based on peptides containing the C-terminal histidinehydroxamic acid moiety and Cu(2+) ions is characterized. Two peptide (tripeptide and pentadecapeptide) hydroxamic acid systems were synthesized and their interactions with Cu(2+) ions were investigated, revealing a high stability of the supramolecular assemblies formed. The supramolecular metallacrown-based L4Cu5 complexes exist at physiological pH in the presence of Cu(2+) ions as is evidenced from the spectroscopic methods, ESI mass spectrometry, and physicochemical techniques.
authors.affiliation: Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, Poland. piotr.stefanowicz@chem.uni.wroc.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Cal
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kotynia
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Jaremko
authors.forename: Mariusz
authors.initials: M
authors.lastname: Jaremko
authors.forename: Marek
authors.initials: M
authors.lastname: Lisowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Cebo
authors.forename: Justyna
authors.initials: J
authors.lastname: Brasuń
authors.forename: Piotr
authors.initials: P
authors.lastname: Stefanowicz
mesh_terms: D000595:Amino Acid Sequence; D002413:Cations, Divalent / Q000138:chemical synthesis / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D006639:Histidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014867:Water / Q000737:chemistry
chemical_list: D002413:Cations, Divalent; D006877:Hydroxamic Acids; D009942:Organometallic Compounds; D010455:Peptides; D014867:Water; C057175:histidinehydroxamic acid; D006639:Histidine; D003300:Copper