title: Malignant metastasizing solitary fibrous tumors of the liver: a report of three cases.
abstract: Solitary fibrous tumors are rare neoplasms of mesenchymal origin that have been reported in various other extrathoracic sites, including the liver. We present a case series of three malignant solitary fibrous tumors of the liver, occurring in two women 74 and 80 years old and one 65-year-old man. No clinical features were predictive of malignancy except the large sizes and synchronous presence of lung metastases in two of the three cases. Histological examinations revealed the presence of high pleomorphic cellularity with nuclear atypia, necrosis and high mitotic ratios. All patients died of disease progression.
authors.forename: Livia
authors.initials: L
authors.lastname: Maccio
authors.forename: Luca Reggiani
authors.initials: LR
authors.lastname: Bonetti
authors.forename: Elena
authors.initials: E
authors.lastname: Siopis
authors.affiliation: Cristian Palmiere MD, CURML, Lausanne, Switzerland, email: cristian.palmiere@chuv.ch.
authors.forename: Cristian
authors.initials: C
authors.lastname: Palmiere
mesh_terms: D000008:Abdominal Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D008175:Lung Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D008297:Male; D008938:Mitosis; D009336:Necrosis; D054364:Solitary Fibrous Tumors / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor