title: The roles of endoplasmic reticulum stress response in female mammalian reproduction.
abstract: Endoplasmic reticulum stress (ERS) activates a protective pathway, called the unfold protein response, for maintaining cellular homeostasis, but cellular apoptosis is triggered by excessive or persistent ERS. Several recent studies imply that the ERS response might have broader physiological roles in the various reproductive processes of female mammals, including embryo implantation, decidualization, preimplantation embryonic development, follicle atresia, and the development of the placenta. This review summarizes the existing data concerning the molecular and biological roles of the ERS response. The study of the functions of the ERS response in mammalian reproduction might provide novel insights into and an understanding of reproductive cell survival and apoptosis under physiological and pathological conditions. The ERS response is a novel signaling pathway for reproductive cell survival and apoptosis. Infertility might be a result of disturbing the ERS response during the process of female reproduction.
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, 75004, People's Republic of China. alnord820119@163.com.
authors.forename: Yanzhou
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, 75004, People's Republic of China.
authors.forename: Xiuying
authors.initials: X
authors.lastname: Pei
authors.affiliation: Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, 712100, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, Ningxia Medical University, Yinchuan, Ningxia, 75004, People's Republic of China.
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Science, Capital Normal University, Beijing, 100048, Peoples' Republic of China. zhch8012@163.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003656:Decidua / Q000502:physiology; D010064:Embryo Implantation; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D005260:Female; D005496:Follicular Atresia / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000196:embryology / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*
keywords: Decidualization; Embryo implantation; Embryonic development; Endoplasmic reticulum stress response; Follicle atresia; Placental development