title: The Effect of Proton Pump Inhibitors on Barrett's Esophagus.
abstract: Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA. Electronic address: Kerry.Dunbar@utsouthwestern.edu.
authors.forename: Kerry B
authors.initials: KB
authors.lastname: Dunbar
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA.
authors.forename: Rhonda F
authors.initials: RF
authors.lastname: Souza
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Medicine, Dallas VA Medical Center, University of Texas Southwestern Medical Center, 4500 South Lancaster Road, GI Lab - CA-111-B1, Dallas, TX 75231, USA.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Spechler
mesh_terms: D000230:Adenocarcinoma / Q000517:prevention & control*; D001471:Barrett Esophagus / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D063646:Carcinogenesis / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000517:prevention & control*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D054328:Proton Pump Inhibitors
keywords: Barrett’s esophagus; Dysplasia; Esophageal cancer; Gastroesophageal reflux disease; Proton pump inhibitor