title: Positive hepatitis B surface antibody is associated with reduced risk of diabetes mellitus in retired female Chinese workers.
abstract: BACKGROUND
  To study the relationship between positivity for hepatitis B surface antibody (HBsAb) and the risk of diabetes mellitus in the retired Chinese population.
  
  
  METHODS
  A cross-sectional analysis was conducted in 900 retired Chinese workers attending a health check-up program. HBsAb, hepatitis B surface antigen, oral glucose tolerance test (OGTT), fasting plasma glucose (FBG), 2-h plasma glucose 2hBG, and insulin levels were collected.
  
  
  RESULTS
  Participants positive for HBsAb were younger, with lower blood pressure, lower FBG and 2hBG serum uric acid, and glutamic pyruvic transaminase than those who were HbsAb negative. There were 306 subjects with impaired glucose tolerance and 121 with type 2 diabetes (T2D) in the present cohort. Using Chi-squared analysis to assess the risk of diabetes, women positive for HBsAb had a lower prevalence of T2D than those negative for HBsAb (15.7% vs 26.5%, respectively; P < 0.01). Multivariate analysis revealed family history of diabetes, age, and waist circumference were independently associated with a higher prevalence of diabetes, and that HBsAb positivity was independently associated with a lower prevalence of diabetes (odds ratio 0.579; 95% confidence interval 0.388-0.918) when adjusted for sex, family history of hypertension and dyslipidemia, and body mass index.
  
  
  CONCLUSIONS
  An HBsAb-positive status is associated with a low rate of diabetes and better metabolic status. A prospective study of patients with known vaccination records is needed to investigate whether hepatitis B virus vaccination could protect against the development of diabetes.
authors.affiliation: Department of Microecology, School of Basic Medical Science, Dalian Medical University, Dalian, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.|Department of Endocrinology and Metabolism, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Haiying
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Shunyu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Su
mesh_terms: D044466:Asian People / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology*; D005260:Female; D005951:Glucose Tolerance Test; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007328:Insulin
keywords: diabetes mellitus; glucose tolerance; hepatitis B surface antibody; 乙型肝炎表面抗体; 糖尿病; 糖耐量