title: Noninvasive vascular imaging of polypoidal choroidal vasculopathy by Doppler optical coherence tomography.
abstract: OBJECTIVE
  To noninvasively investigate the vascular architecture of polypoidal lesions in polypoidal choroidal vasculopathy (PCV) using Doppler optical coherence tomography (OCT), and to evaluate the clinical usefulness of Doppler OCT for the assessment of therapeutic effects in PCV.
  
  
  METHODS
  Fifteen eyes of 15 patients with treatment-naïve PCV were prospectively studied. Vascular imaging was obtained using 1060-nm swept-source Doppler OCT, and compared with indocyanine green angiography (ICGA) images. The therapeutic effect of three consecutive intravitreal aflibercept injections was evaluated with ICGA and Doppler OCT.
  
  
  RESULTS
  In Doppler OCT images, polypoidal lesions were clearly detected at the corresponding locations of lesions in the ICGA images. By being insensitive to dye leakage, Doppler OCT identified the complicated vascular structure in the polypoidal lesions. The identified mean area of the polypoidal lesions in the Doppler OCT images (0.04 mm(2)) was significantly smaller than that of the ICGA images (0.13 mm(2)). Polypoidal lesions were located in the retinal pigment epithelial detachment in 13 eyes, in the choroid in one eye, and in both the retinal pigment epithelial detachment and choroid in one eye. After intravitreal aflibercept treatment, areas of polypoidal lesions in the ICGA images were decreased in 14 of 15 eyes. This therapeutic effect was clearly confirmed in the Doppler OCT images.
  
  
  CONCLUSIONS
  Doppler OCT imaging clearly detected fine vascular structures at the polypoidal lesions in PCV. Doppler OCT might be useful for the diagnosis and evaluation of therapeutic effects in PCV.
authors.affiliation: Department of Ophthalmology Tokyo Medical University, Ibaraki Medical Centre, Ami, Japan 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Miura
authors.affiliation: Department of Ophthalmology Tokyo Medical University, Ibaraki Medical Centre, Ami, Japan 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Muramatsu
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yasuno
authors.affiliation: Department of Ophthalmology Tokyo Medical University, Ibaraki Medical Centre, Ami, Japan 2Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Iwasaki
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D044466:Asian People; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D058449:Intravitreal Injections; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000188:drug therapy / Q000473:pathology*; D011446:Prospective Studies; D040262:Receptors, Vascular Endothelial Growth Factor / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D041623:Tomography, Optical Coherence / Q000379:methods*; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D011993:Recombinant Fusion Proteins; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C533178:aflibercept; D040262:Receptors, Vascular Endothelial Growth Factor