title: Lysophospholipids from the Guangxi Sponge Spirastrella purpurea.
abstract: Four known (1-4) and two new (5 and 6) lysophospholipids were isolated from the sponge Spirastrella purpurea from Weizhou Island, Guangxi Autonomous Region, China. The structures of the new compounds (5 and 6) were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments. The known compounds (1-4) were identified by comparison of their spectroscopic data and specific optical rotation with those reported in the literature. The isolated compounds displayed various moderate in vitro antifungal activities against four fungi (Cryptococcus neoformans, Candida glabrata, Trichophyton rubrum, and Aspergillus fumigatus), whereas they displayed no neuroprotective activity against Aβ25-35-induced SH-SY5Y cell damage.
authors.affiliation: School of Pharmacy, Nanchang University, 461 Bayi Road, Nanchang, 330006, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Lin
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Ai-Hong
authors.initials: AH
authors.lastname: Liu
authors.forename: Li-Gong
authors.initials: LG
authors.lastname: Yao
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Shui-Chun
authors.initials: SC
authors.lastname: Mao
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D006801:Humans; D008246:Lysophospholipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D008246:Lysophospholipids