title: Analytical investigation of bilayer lipid biosensor based on graphene.
abstract: Graphene is another allotrope of carbon with two-dimensional monolayer honeycomb. Owing to its special characteristics including electrical, physical and optical properties, graphene is known as a more suitable candidate compared to other materials to be used in the sensor application. It is possible, moreover, to use biosensor by using electrolyte-gated field effect transistor based on graphene (GFET) to identify the alterations in charged lipid membrane properties. The current article aims to show how thickness and charges of a membrane electric can result in a monolayer graphene-based GFET while the emphasis is on the conductance variation. It is proposed that the thickness and electric charge of the lipid bilayer (LLP and QLP) are functions of carrier density, and to find the equation relating these suitable control parameters are introduced. Artificial neural network algorithm as well as support vector regression has also been incorporated to obtain other models for conductance characteristic. The results comparison between analytical models, artificial neural network and support vector regression with the experimental data extracted from previous work show an acceptable agreement.
authors.affiliation: Institute of High Voltage and High Current, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Elnaz
authors.initials: E
authors.lastname: Akbari
authors.affiliation: Institute of High Voltage and High Current, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia zolkafle@fke.utm.my.
authors.forename: Zolkafle
authors.initials: Z
authors.lastname: Buntat
authors.affiliation: Department of Communications Engineering, University of Sistan and Baluchestan, Zahedan, Iran.
authors.forename: Elmira
authors.initials: E
authors.lastname: Shahraki
authors.affiliation: Department of Electrical Engineering, Neyriz Branch, Islamic Azad University, Neyriz, Iran.
authors.forename: Ramtin
authors.initials: R
authors.lastname: Parvaz
authors.affiliation: Department of Electrical Engineering, Islamic Azad University, Yasooj, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Kiani
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004553:Electric Conductivity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D008051:Lipid Bilayers / Q000032:analysis / Q000737:chemistry*; D008564:Membrane Potentials; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014173:Transistors, Electronic
chemical_list: D008051:Lipid Bilayers; D006108:Graphite
keywords: GFET; Monolayer graphene; artificial neural network; conductance; lipid bilayer; support vector regression