title: Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates.
abstract: To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen.
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA sxshen@duke.edu gdt@duke.edu.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Duffy
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Howington
authors.affiliation: Mucosal Infection & Immunity Group, Section of Infectious Diseases, Imperial College London, London, United Kingdom.
authors.forename: Alethea
authors.initials: A
authors.lastname: Cope
authors.affiliation: Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Shanmugalakshmi
authors.initials: S
authors.lastname: Sadagopal
authors.affiliation: Vaccine & Gene Therapy Institute (VGTI), Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Haesun
authors.initials: H
authors.lastname: Park
authors.affiliation: Advanced Bioscience Laboratories Inc., Rockville, Maryland, USA.
authors.forename: Ranajit
authors.initials: R
authors.lastname: Pal
authors.affiliation: Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Suefen
authors.initials: S
authors.lastname: Kwa
authors.affiliation: Laboratory of AIDS Immunopathogenesis, Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Song
authors.initials: S
authors.lastname: Ding
authors.affiliation: Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA AIDS Healthcare Foundation, Los Angeles, California, USA.
authors.forename: Otto O
authors.initials: OO
authors.lastname: Yang
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Genevieve G
authors.initials: GG
authors.lastname: Fouda
authors.affiliation: CEA, Division of Immuno-Virology-IMDIT Center, DSV, iMETI, Fontenay-aux-Roses, Inserm-U1184, Université Paris-Sud, Orsay, France.
authors.forename: Roger
authors.initials: R
authors.lastname: Le Grand
authors.affiliation: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Bolton
authors.affiliation: Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Esteban
authors.affiliation: Sanofi Pasteur, Swiftwater, PA, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Phogat
authors.affiliation: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Roederer
authors.affiliation: Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Rama R
authors.initials: RR
authors.lastname: Amara
authors.affiliation: Vaccine & Gene Therapy Institute (VGTI), Oregon Health & Science University, Portland, Oregon, USA.
authors.forename: Louis J
authors.initials: LJ
authors.lastname: Picker
authors.affiliation: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Seder
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: M Juliana
authors.initials: MJ
authors.lastname: McElrath
authors.affiliation: Novartis Vaccines and Diagnostics, Inc., Cambridge, Massachusetts, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Barnett
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Sallie R
authors.initials: SR
authors.lastname: Permar
authors.affiliation: Mucosal Infection & Immunity Group, Section of Infectious Diseases, Imperial College London, London, United Kingdom.
authors.forename: Robin
authors.initials: R
authors.lastname: Shattock
authors.affiliation: Institute for Human Virology, Baltimore, Maryland, USA.
authors.forename: Anthony L
authors.initials: AL
authors.lastname: DeVico
authors.affiliation: Human Retrovirus Pathogenesis Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
authors.forename: Barbara K
authors.initials: BK
authors.lastname: Felber
authors.affiliation: Human Retrovirus Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA.
authors.forename: George N
authors.initials: GN
authors.lastname: Pavlakis
authors.affiliation: Laboratory of AIDS Immunopathogenesis, Service of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pantaleo
authors.affiliation: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Álamos, New Mexico, USA.
authors.forename: Bette T
authors.initials: BT
authors.lastname: Korber
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Montefiori
authors.affiliation: Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA sxshen@duke.edu gdt@duke.edu.
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Tomaras
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000235:genetics / Q000276:immunology*; D000918:Antibody Specificity; D000939:Epitopes / Q000235:genetics*; D015497:HIV-1 / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D046228:Microarray Analysis; D011323:Primates / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013045:Species Specificity; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000939:Epitopes; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins