title: Amorphastilbol exerts beneficial effects on glucose and lipid metabolism in mice consuming a high-fat-diet.
abstract: In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low-density lipoprotein-cholesterol levels are decreased in AF- or APH-treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin-signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.
authors.affiliation: Natural Medicine Center, KIST Gangneung Institute, Gangneung, Gangwon 210-340, Republic of Korea.
authors.forename: Woojung
authors.initials: W
authors.lastname: Lee
authors.affiliation: Natural Medicine Center, KIST Gangneung Institute, Gangneung, Gangwon 210-340, Republic of Korea.
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.affiliation: Natural Medicine Center, KIST Gangneung Institute, Gangneung, Gangwon 210-340, Republic of Korea.
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.affiliation: College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 534-729, Republic of Korea.
authors.forename: Goo
authors.initials: G
authors.lastname: Yoon
authors.affiliation: Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Gyu-Un
authors.initials: GU
authors.lastname: Bae
authors.affiliation: Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
authors.forename: Yong Kee
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Natural Medicine Center, KIST Gangneung Institute, Gangneung, Gangwon 210-340, Republic of Korea.
authors.forename: Su-Nam
authors.initials: SN
authors.lastname: Kim
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D002186:Cannabinoids / Q000494:pharmacology*; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000378:metabolism
chemical_list: D019440:Anti-Obesity Agents; D002186:Cannabinoids; D007004:Hypoglycemic Agents; C575104:amorphastilbol; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; C516609:Ptpn1 protein, mouse; D005947:Glucose