title: GCF Resistin As A Novel Marker in Patients with Chronic Periodontitis and Rheumatoid Arthritis.
abstract: BACKGROUND
  The associational studies between periodontitis and rheumatoid arthritis are less documented, although they are found to have similar inflammatory pathogenesis. Resistin, a novel adipokine is suggested to be a common link between periodontitis and rheumatoid arthritis. The aim of the present study was to reinforce the inter-relationship between periodontitis and rheumatoid arthritis by using resistin as a potent inflammatory marker.
  
  
  METHODS
  Hundred patients (aged >30 y) of either sex were selected for this study and were divided equally into four groups of 25 patients each. Group A consisted of healthy individuals, Group B consisted of patients with chronic periodontitis, Group C of patients with rheumatoid arthritis and Group D had patients suffering from both arthritis and periodontitis. Periodontal parameters assessed were plaque index (PI), modified gingival index (GI) and probing depth (PD). Panoramic radiographs were taken to confirm the diagnosis of periodontitis. Rheumatoid arthritis was confirmed by the rheumatologists and seropositivity for rheumatoid factor (RF) was checked. Resistin levels were analysed in GCF collected from all the four groups and statistical analysis was done by using Pearson correlation coefficient.
  
  
  RESULTS
  The GCF of all the patients showed presence of resistin. The level of resistin was highest in Group D patients and least in Group A patients. On analysing the samples together positive co-relation was found between GCF resistin and PD, PI, GI and RF.
  
  
  CONCLUSIONS
  Resistin levels are increased in both chronic periodontitis and rheumatoid arthritis. Therefore, the increased level of GCF resistin can be regarded as potential inflammatory marker for periodontitis and rheumatoid arthritis.
authors.affiliation: Professor and HOD, Department of Periodontology, RKDF Dental College , Bhopal, Madhya Pradesh, India .
authors.forename: Manoj
authors.initials: M
authors.lastname: Mittal
authors.affiliation: Senior Lecturer, Department of Conservative Dentistry and Endodontics, RKDF Dental College , Bhopal, Madhya Pradesh, India .
authors.forename: Basit
authors.initials: B
authors.lastname: Hassan
authors.affiliation: Senior Lecturer, Department of Periodontics, Karnavati School of Dentistry , Gandhinagar, India .
authors.forename: Khushboo
authors.initials: K
authors.lastname: Desai
authors.affiliation: Reader, Department of Periodontics, Karnavati School of Dentistry , Gandhinagar, Gujarat, India .
authors.forename: Shilpa
authors.initials: S
authors.lastname: Duseja
authors.affiliation: Reader, Department of Periodontics, Karnavati School of Dentistry , Gandhinagar, Gujarat, India .
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Reader, Department of Conservative Dentistry and Endodontics, Vydehi Institute of Dental Sciences , Bengaluru, Karnataka, India .
authors.forename: Sharaschandra G
authors.initials: SG
authors.lastname: Reddy
keywords: Adipokines; Inflammatory diseases; Periodontal disease