title: Risk Factors for Resistance to β-Lactam/β-Lactamase Inhibitors and Ertapenem in Bacteroides Bacteremia.
abstract: The objective of this study was to determine risk factors for the development of resistance to β-lactams/β-lactamase inhibitors (βL/βLIs) and ertapenem among Bacteroides species bacteremia. We conducted a retrospective case-control study of 101 adult patients with Bacteroides species bacteremia at a 1,051-bed tertiary care medical center. The duration of exposure to βL/βLIs (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.08 to 2.31) was the only independent risk factor for resistance.
authors.affiliation: Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland, USA jsmit276@jhmi.edu.
authors.forename: Janessa M
authors.initials: JM
authors.lastname: Smith
authors.affiliation: Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors.forename: Edina
authors.initials: E
authors.lastname: Avdic
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Pranita D
authors.initials: PD
authors.lastname: Tamma
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, Maryland, USA.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Division of Medical Microbiology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Carroll
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Sara E
authors.initials: SE
authors.lastname: Cosgrove
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy; D001439:Bacteroides / Q000145:classification / Q000187:drug effects*; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000453:epidemiology; D016022:Case-Control Studies; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D000077727:Ertapenem; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers; D065093:beta-Lactamase Inhibitors / Q000627:therapeutic use*; D047090:beta-Lactams / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D000077727:Ertapenem