title: Association between Interleukin-1β Gene -511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis.
abstract: BACKGROUND
  Interleukin-1β (IL-1β) is an important inflammatory cytokine. The associations between IL-1β gene -511C>T/+3954C>T polymorphisms and aggressive periodontitis (AgP) susceptibility have been conflicting. We therefore conducted a meta-analysis to investigate the association of IL-1β genetic polymorphisms with susceptibility to AgP.
  
  
  METHODS
  PubMed and Embase electronic databases were searched for relevant studies. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the association between IL-1β polymorphisms and AgP risk. Heterogeneity, publication bias, and sensitivity analysis were performed to guarantee the statistical power.
  
  
  RESULTS
  Twenty published studies involving 965 patients and 1234 control subjects were included. No significant association between IL-1β polymorphisms and AgP was found. For -511C>T (T vs. C: OR=0.966, 95%CI=0.696-1.341, P=0.869; CT vs. CC: OR=0.936, 95%CI=0.761-1.151; TT vs. CC: OR=0.892, 95%CI=0.464-1.715, P=0.719; CT+TT vs. CC: OR=1.026, 95%CI=0.795-1.323; TT vs. CC+CT: OR=0.864, 95%CI=0.436-1.713). For +3954C>T (T vs. C: OR=1.069, 95%CI=0.901-1.268; CT vs. CC: OR=0.921, 95%CI=0.699-1.212; TT vs. CC: OR=1.064, 95%CI=0.747-1.515; CT+TT vs. CC: OR=0.990, 95%CI=0.764-1.283; TT vs. CC+CT: OR=1.229, 95%CI=0.919-1.643). Subgroup analyses were conducted with HWE, ethnicity, and study design, and no significant association was detected.
  
  
  CONCLUSIONS
  These results demonstrate that IL-1β -511C>T and +3954C>T polymorphisms are not the risk factors for developing AgP.
authors.affiliation: Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Hu
authors.affiliation: Children Medical Center, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Guang-Bin
authors.initials: GB
authors.lastname: Jiang
authors.affiliation: Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Rui-Xia
authors.initials: RX
authors.lastname: Yuan
authors.affiliation: Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Niu
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
mesh_terms: D010520:Aggressive Periodontitis / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D039781:PubMed
chemical_list: D053583:Interleukin-1beta