title: Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage.
abstract: Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.
authors.affiliation: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India).
authors.forename: Debasish
authors.initials: D
authors.lastname: Bhowmick
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore-560012 (India).
authors.forename: Shubhi
authors.initials: S
authors.lastname: Srivastava
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore-560012 (India). patrick@biochem.iisc.ernet.in.
authors.forename: Patrick
authors.initials: P
authors.lastname: D'Silva
authors.affiliation: Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012 (India). mugesh@ipc.iisc.ernet.in.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Mugesh
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000737:chemistry*; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D054464:Peroxiredoxins / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016566:Organoselenium Compounds; D017382:Reactive Oxygen Species; D054464:Peroxiredoxins; D005979:Glutathione Peroxidase
keywords: DNA damage; antioxidants; glutathione peroxidase; reactive oxygen species; selenium