title: Biomarkers in Interstitial lung diseases.
abstract: Interstitial lung diseases (ILD)s represent a heterogeneous group of rare respiratory disorders, mostly chronic and associated with high morbidity and mortality. They are complex diseases that remain, in children, largely underdiagnosed and difficult to manage. Therefore, identification of biomarkers, which could be used for ILD diagnosis, measurements of disease severity and progression, and responsiveness to treatments, is a major challenge for clinical practice and for translational research. The present review focuses on blood biomarkers and provides an overview on the current information on molecular parameters of interest for ILD patient management.
authors.affiliation: Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Trousseau, Service de pneumologie pédiatrique; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR_S 933; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06.
authors.forename: Nadia
authors.initials: N
authors.lastname: Nathan
authors.affiliation: Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Trousseau, Service de pneumologie pédiatrique; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR_S 938; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06.
authors.forename: Harriet
authors.initials: H
authors.lastname: Corvol
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR_S 933; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06; Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Trousseau, Unité de génétique moléculaire; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06.
authors.forename: Serge
authors.initials: S
authors.lastname: Amselem
authors.affiliation: Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Trousseau, Service de pneumologie pédiatrique; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR_S 933; Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris06. Electronic address: annick.clement@trs.aphp.fr.
authors.forename: Annick
authors.initials: A
authors.lastname: Clement
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D019742:Chemokines, CC / Q000378:metabolism; D002648:Child; D000071451:Chitinase-3-Like Protein 1 / Q000378:metabolism; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D017563:Lung Diseases, Interstitial / Q000378:metabolism*; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism; D018396:Mucin-1 / Q000378:metabolism; D055257:Mucin-5B / Q000378:metabolism; D037661:Pulmonary Surfactant-Associated Proteins / Q000378:metabolism
chemical_list: D015415:Biomarkers; C111792:CCL18 protein, human; C084533:CHI3L1 protein, human; D019742:Chemokines, CC; D000071451:Chitinase-3-Like Protein 1; C060192:MUC1 protein, human; C524578:MUC5B protein, human; D018396:Mucin-1; D055257:Mucin-5B; D037661:Pulmonary Surfactant-Associated Proteins; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7
keywords: Biomarkers; Idiopathic pulmonary fibrosis; Interstitial lung diseases