title: Interplay between vitamin D status and antiviral therapy among chronic hepatitis C Egyptian patients.
abstract: Vitamin D has been shown to play an important immunomodulatory role; deficiency of vitamin D has been recently associated to the lack of response to antiviral therapy in chronic hepatitis C patients. This study evaluated the interrelationship between serum level of vitamin D and early response to antiviral therapy in Egyptian patients with chronic HCV infection. A total of 45 patients with chronic HCV infection who received antiviral treatment (Pegylated interferon and Ribavirin), their vitamin D serum level was assessed once at the start of treatment and 12 weeks later, when the EVR was determine by Quantitative HCV-RNA by PCR. The results showed that vitamin D status has no correlation with viral load and hepatitis activity by biopsy and without significant association between vitamin D deficiency and the antiviral therapy response. However, there was significance improvement in level of vitamin D after 12 weeks of receiving the antiviral therapy of HCV.
authors.forename: Moustafa Hamed
authors.initials: MH
authors.lastname: Abd Elalim
authors.forename: Doaa Zakaria
authors.initials: DZ
authors.lastname: Zaky
authors.forename: Ibrahim Abd el Ghany
authors.initials: IA
authors.lastname: Motawae
authors.forename: Nesreen A
authors.initials: NA
authors.lastname: Mohamed
authors.forename: Adly Nabih
authors.initials: AN
authors.lastname: Nagib
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004534:Egypt / Q000453:epidemiology; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012254:Ribavirin / Q000008:administration & dosage / Q000627:therapeutic use*; D014807:Vitamin D / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000998:Antiviral Agents; D014807:Vitamin D; D012254:Ribavirin