title: Molecular Interactions of β-(1→3)-Glucans with Their Receptors.
abstract: β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi. Research has now established that β-(1→3)-glucans can trigger different immune responses and act as efficient immunostimulating agents. They constitute prevalent sources of carbons for microorganisms after subsequent recognition by digesting enzymes. Nevertheless, mechanisms associated with both roles are not yet clearly understood. This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. laurent.legentil@ensc-rennes.fr.|Université européenne de Bretagne, F-35000 Rennes, France. laurent.legentil@ensc-rennes.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. franck.paris@ensc-rennes.fr.|Université européenne de Bretagne, F-35000 Rennes, France. franck.paris@ensc-rennes.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Paris
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. caroline.ballet@ensc-rennes.fr.|Université européenne de Bretagne, F-35000 Rennes, France. caroline.ballet@ensc-rennes.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Ballet
authors.affiliation: INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. sophie.trouvelot@u-bourgogne.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Trouvelot
authors.affiliation: INRA, UMR AgroSup/INRA/uB 1347 Agroécologie, Pôle Interactions Plantes-Microorganismes-ERL CNRS 6300, 21065 Dijon Cedex, France. xavier.daire@dijon-inra.fr.
authors.forename: Xavier
authors.initials: X
authors.lastname: Daire
authors.affiliation: Department of Pathology, University of Louisville, Louisville, KY 40202, USA. vaclav.vetvicka@louisville.edu.
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. vincent.ferrieres@ensc-rennes.fr.|Université européenne de Bretagne, F-35000 Rennes, France. vincent.ferrieres@ensc-rennes.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000276:Adjuvants, Immunologic / Q000235:genetics / Q000378:metabolism*; D000363:Agaricales / Q000235:genetics / Q000378:metabolism; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D002523:Edible Grain / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D043326:Glucan 1,3-beta-Glucosidase / Q000235:genetics / Q000276:immunology*; D006017:Glycolipids / Q000276:immunology / Q000378:metabolism; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics / Q000276:immunology*; D016177:Macrophage-1 Antigen / Q000235:genetics / Q000276:immunology*; D037241:Mannose-Binding Lectins / Q000235:genetics / Q000276:immunology; D051116:Receptors, Scavenger / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D058009:Stramenopiles / Q000235:genetics / Q000378:metabolism; D047071:beta-Glucans / Q000378:metabolism*; D000099181:Dectin-1
chemical_list: D000276:Adjuvants, Immunologic; D015703:Antigens, CD; D043326:Glucan 1,3-beta-Glucosidase; D006017:Glycolipids; D037181:Lectins, C-Type; D016177:Macrophage-1 Antigen; D037241:Mannose-Binding Lectins; D051116:Receptors, Scavenger; D047071:beta-Glucans; C121916:CD207 protein, human; C546929:CLEC7A protein, human; D000099181:Dectin-1
keywords: CBM; CR3; Dectin-1; glycolipids; langerin; β-(1→3)-glucans