title: Acid-sensing ion channels: potential therapeutic targets for neurologic diseases.
abstract: Maintaining the physiological pH of interstitial fluid is crucial for normal cellular functions. In disease states, tissue acidosis is a common pathologic change causing abnormal activation of acid-sensing ion channels (ASICs), which according to cumulative evidence, significantly contributes to inflammation, mitochondrial dysfunction, and other pathologic mechanisms (i.e., pain, stroke, and psychiatric conditions). Thus, it has become increasingly clear that ASICs are critical in the progression of neurologic diseases. This review is focused on the importance of ASICs as potential therapeutic targets in combating neurologic diseases.
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou, 215004 China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou, 215004 China.
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Cheng
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou, 215004 China ; Institute of Neuroscience, Soochow University, Suzhou, 215123 China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, the Second Affiliated Hospital of Soochow University, Soochow University, 1055 Sanxiang Road, Suzhou, 215004 China ; Institute of Neuroscience, Soochow University, Suzhou, 215123 China ; Beijing Key Laboratory for Parkinson's Disease, Beijing, 100053 China.
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Liu
keywords: Acid sensing ionic channels; Neurodegeneration; Neurologic diseases; Pathophysiology