title: PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Uterine infection: linking infection and innate immunity with infertility in the high-producing dairy cow.
abstract: Uterine contamination with bacteria is ubiquitous in the postpartum dairy cow. Nearly one-half of all postpartum dairy cows develop clinical disease resulting in metritis and endometritis, which cause depressed milk production and infertility. The causative links between uterine infection and infertility include a hostile uterine environment, disrupted endocrine signaling, and perturbations in ovarian function and oocyte development. In this review we consider the various mechanisms linking uterine infection with infertility in the dairy cow, specifically 1) innate immune signaling in the endometrium, 2) alteration in endocrine signaling in response to infectious agents, and 3) impacts of infection on ovarian function, oocyte development, and follicular development. Normal ovarian follicular and oocyte development requires a series of temporally and spatially orchestrated events; however, several of the cellular pathways required for ovarian function are also used during the innate immune response to bacterial pathogens. We propose that activation of cellular pathways during this immune response has a negative impact on ovarian physiology, which is manifest as infertility detected after the clearance of the bacteria. This review highlights how new insights into infection and immunity in cattle are linked to infertility.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bromfield
authors.forename: J E P
authors.initials: JE
authors.lastname: Santos
authors.forename: J
authors.initials: J
authors.lastname: Block
authors.forename: R S
authors.initials: RS
authors.lastname: Williams
authors.forename: I M
authors.initials: IM
authors.lastname: Sheldon
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000382:microbiology*; D004716:Endometritis / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D005260:Female; D007113:Immunity, Innate / Q000276:immunology*; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D049590:Postpartum Period / Q000276:immunology*