title: The Association of BDNF Val66Met Polymorphism With Trait Anxiety in Panic Disorder.
abstract: Recent studies indicate that early-onset panic disorder (PD) may show distinct clinical characteristics. The authors compared patients with early-onset PD, patients with late-onset PD, and healthy control subjects in terms of brain-derived neurotrophic factor (BDNF), the Val66Met polymorphism, State-Trait Anxiety Inventory (STAI) scores, and the Revised NEO Personality Inventory. In patients with early-onset PD, the STAI-T score was high in the Met/Met group, whereas the STAI-T score of the Val/Val group tended to be higher for healthy control subjects. The conflicting effect of the BDNF genotype between patients with early-onset PD and healthy control subjects suggests that the BDNF Met/Met genotype may increase trait anxiety in early-onset PD.
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Konishi
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Takeshi
authors.initials: T
authors.lastname: Otowa
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Hisanobu
authors.initials: H
authors.lastname: Kaiya
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Motohiro
authors.initials: M
authors.lastname: Okada
authors.affiliation: From the Dept. of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Mie, Japan (YK, HT, MO); the Dept. of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan (TO); the Laboratory of Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan (TS); the Research Center for Panic Disorder, Nagoya Mental Clinic, Nagoya, Japan (HK); and the Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan (YO).
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001007:Anxiety / Q000209:etiology / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D008875:Middle Aged; D016584:Panic Disorder / Q000150:complications* / Q000235:genetics; D010555:Personality Inventory; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011581:Psychological Tests; D011795:Surveys and Questionnaires; D014633:Valine / Q000235:genetics*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine