title: Late neurological sequelae due to brainstem irradiation for an assumed glioma.
abstract: OBJECTIVE
  There is ongoing discussion whether radiotherapy might be beneficial in the treatment of intracranial cavernomas, however long-term sequelae due to brainstem irradiation may exist.
  
  
  METHODS
  The case of a 72-year-old female is reported who received radiotherapy in the pre-MRI era due to a suspected intra-axial pontine lesion. Later on she developed severe trigeminal neuropathy and an MRI was performed 27 years after irradiation of the brainstem. On these images a large cavernous malformation with signs of multiple haemorrhages instead of the pontine glioma was seen accompanied by a substantial atrophy of brainstem structures.
  
  
  CONCLUSIONS
  This case impressively demonstrates the long-term outcome of brainstem irradiation and reflects that cavernomas do not respond to radiotherapy.
authors.forename: Florian
authors.initials: F
authors.lastname: Roser
authors.forename: Marcos S
authors.initials: MS
authors.lastname: Tatagiba
authors.forename: Florian H
authors.initials: FH
authors.lastname: Ebner
mesh_terms: D000368:Aged; D001284:Atrophy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D001933:Brain Stem / Q000473:pathology / Q000528:radiation effects*; D016371:Cranial Irradiation / Q000009:adverse effects*; D005260:Female; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D020433:Trigeminal Nerve Diseases / Q000209:etiology*