title: Development of an injection molded ethylene-vinyl acetate copolymer (EVA) intravaginal insert for the delivery of progesterone to cattle.
abstract: The purpose of this study was to develop a new injection-molded intravaginal insert manufactured from ethylene-vinyl acetate containing progesterone for a 7-day insertion period in cattle. The manufacturing process resulted in a reduction in the residual drug compared to the silicone insert available while still maintaining biological performance.
authors.affiliation: Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Predio CCT-CONICET Santa Fe, Ruta Nacional 168, Km 1, 3000 Santa Fe, Argentina. Electronic address: alecappadoro@gmail.com.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cappadoro
authors.affiliation: Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Predio CCT-CONICET Santa Fe, Ruta Nacional 168, Km 1, 3000 Santa Fe, Argentina.
authors.forename: J A
authors.initials: JA
authors.lastname: Luna
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle / Q000502:physiology*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D005260:Female; D011145:Polyvinyls / Q000737:chemistry*; D011374:Progesterone / Q000008:administration & dosage*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D011374:Progesterone
keywords: Controlled release; Estrous control; Ethylene-vinyl acetate; Intravaginal drug delivery; Progesterone delivery