title: [Role of transcription factors in transdifferentiation of the gastric mucosa].
abstract: The analysis of intestinal differentiation transcription factor CDX2 in the gastric mucosa biopsies has been carried out. It was established that CDX2 by itself promoter activation pathway can obtain intestinal phenotype for gastric mucosa cells. The loss of CDX2 expression in the nuclei of metaplastic epithelium may serve as a predictor of gastric mucosa malignization.
authors.forename: S V
authors.initials: SV
authors.lastname: Vernygorodskyi
authors.forename: L V
authors.initials: LV
authors.lastname: Degtiariova
authors.forename: O I
authors.initials: OI
authors.lastname: Iatsyna
authors.forename: Ya B
authors.initials: YB
authors.lastname: Blume
authors.forename: A I
authors.initials: AI
authors.lastname: Yemets
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D000071616:CDX2 Transcription Factor; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D054338:Cell Transdifferentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D016481:Helicobacter Infections / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D010641:Phenotype; D011401:Promoter Regions, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: D015415:Biomarkers; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins