title: In Vivo Anti-tumor Effects of the Ethanol Extract of Gleditsia sinensis Thorns and Its Active Constituent, Cytochalasin H.
abstract: Angiogenesis is the process of new vessel formation from pre-existing blood vasculature and is critical for continuous tumor growth. We previously reported that an ethanolic extract of Gleditsia sinensis thorns (EEGS) and its active constituent, cytochalasin H, have anti-angiogenic activity in vitro and in vivo via suppression of endothelial cell functions. In the present study, EEGS and cytochalasin H were observed to efficiently inhibit tumor growth in an in ovo xenograft model without significant toxicity. We repeatedly observed the anti-tumor and anti-metastatic effects of EEGS in representative animal models. These results suggest that EEGS and its active constituent, cytochalasin H, are potential candidates for the development of anti-angiogenic cancer drugs.
authors.affiliation: KM-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental  Medicine; 1672 Yuseong-daero, Yuseong-gu, Daejeon 305–811, Republic of Korea: b College of Pharmacy, Chungbuk  National University; 52 Naesudong-ro, Seowon-gu, Cheongju 362–763, Republic of Korea.
authors.forename: Jin-Mu
authors.initials: JM
authors.lastname: Yi
authors.forename: Jinhee
authors.initials: J
authors.lastname: Kim
authors.forename: Jong-Shik
authors.initials: JS
authors.lastname: Park
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: You Jin
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Ok-Sun
authors.initials: OS
authors.lastname: Bang
authors.forename: No Soo
authors.initials: NS
authors.lastname: Kim
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002642:Chick Embryo; D003572:Cytochalasins / Q000494:pharmacology / Q000627:therapeutic use*; D031501:Gleditsia / Q000737:chemistry*; D006801:Humans; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D008517:Phytotherapy; D019441:Plant Epidermis; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D003572:Cytochalasins; D010936:Plant Extracts; C034891:cytochalasin H