title: Analgesic effects of lappaconitine in leukemia bone pain in a mouse model.
abstract: Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine treatment at day 15, 17 and 19 could effectively reduce the spontaneous pain scoring values, restore reduced degree in the inclined-plate test induced by injection of K562 cells, as well as restore paw mechanical withdrawal threshold and paw withdrawal thermal latency induced by injection of K562 cells to the normal levels. Additionally, the molecular mechanisms of lappaconitine's analgesic effects may be related to affect the expression levels of endogenous opioid system genes (POMC, PENK and MOR), as well as apoptosis-related genes (Xiap, Smac, Bim, NF-κB and p53). Our present results indicated that lappaconitine may become a new analgesic agent for leukemia bone pain management.
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Xiao-Cui
authors.initials: XC
authors.lastname: Zhu
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Chen-Tao
authors.initials: CT
authors.lastname: Ge
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Pan
authors.initials: P
authors.lastname: Wang
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Zhang
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Yuan-Yang
authors.initials: YY
authors.lastname: Yu
authors.affiliation: Lab of Proteomics & Molecular Enzymology, School of Life Sciences, Zhejiang Sci-Tech University , Hangzhou , China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Fu
keywords: Analgesia; Bone pain; Lappaconitine; Leukemia