title: Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial.
abstract: Article chosen Ebinger M, Winter B, Wendt M, et al. Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA 2014;311(16):1622-31. Clinical question Does prehospital thrombolysis in specialized ambulances reduce delay to thrombolysis in acute ischemic stroke?
  
  
  OBJECTIVE
  To determine the effect of prehospital thrombolysis for acute ischemic stroke administered in specialized ambulances on delay in thrombolytic administration, thrombolysis rate, post-thrombolysis intracerebral hemorrhage, and 7-day mortality.
authors.affiliation: *Royal College of Surgeons in Ireland,National University of Ireland,Dublin.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fakhraldeen
authors.affiliation: ‡Department of Emergency Medicine,McGill University Health Centre,Montreal,QC.
authors.forename: Eli
authors.initials: E
authors.lastname: Segal
authors.affiliation: ‡Department of Emergency Medicine,McGill University Health Centre,Montreal,QC.
authors.forename: François
authors.initials: F
authors.lastname: de Champlain
mesh_terms: D000208:Acute Disease; D000552:Ambulances; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D004632:Emergency Medical Services / Q000379:methods*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D012189:Retrospective Studies; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D005343:Fibrinolytic Agents
keywords: Prehospital; mobile unit; reperfusion delays; stroke; thrombolysis