title: Analgesic effects of oligonol, acupuncture and quantum light therapy on chronic nonbacterial prostatitis.
abstract: BACKGROUND
  Chronic Nonbacterial Prostatitis (CNBP) is a condition that frequently causes long-term pain and a significant decrease in the quality of life.
  
  
  OBJECTIVE
  The present study aimed to examine the analgesic effects of oligonol, acupuncture, quantum light therapy and their combinations on estrogen-induced CNBP in rats.
  
  
  METHODS
  This experimental study was conducted in Edirne, Turkey, using a simple randomized allocation. A total of 90 adult male Wistar rats were randomized into 9 groups of 10 rats each: Group I, control; Group II, CNBP, Group III, oligonol only, Group IV, acupuncture only; Group V, quantum only; Group VI, oligonol + quantum; Group VII, acupuncture + oligonol; Group VIII, quantum + acupuncture; Group IX, acupuncture + quantum + oligonol. Oligonol treatment was given at a dose of 60 mg/day for 6 weeks. Conceptual vessels (CV) 3 and 4, and bilaterally urinary bladder (Bl) 32 and 34 points were targeted with 1-hour acupuncture stimulation. The quantum light therapy was applied in 5-minute sessions for 6 weeks (3-times/a week). For pain measurements, mechanical pressure was applied to a point 2 cm distal to the root of the tail to elicit pain and consequent parameters (peak force, latency time of response and total length of measurement) were assessed.
  
  
  RESULTS
  Analgesic effects were observed with all treatment regimens; however, the most prominent median analgesic effect was shown in the quantum light therapy in combination with acupuncture for estrogen-induced CNBP (PF1 = 663.9, PF2 = 403.4) (P = 0.012). Furthermore, we observed that monotherapy with quantum light showed a better analgesic efficacy as compared to oligonol and acupuncture monotherapies (PF1 = 1044.6, PF2 = 661.2) (P = 0.018, P = 0.008, P = 0.018; respectively).
  
  
  CONCLUSIONS
  All treatment modalities showed a significant analgesic effect on CNBP in rats, being most prominent with the quantum light therapy.
authors.affiliation: Department of Urology, Medical Faculty, Trakya University, Edirne, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Akdere
authors.affiliation: Departments of Anesthesiology and Algology, Medical Faculty, Trakya University, Edirne, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Oztekin
authors.affiliation: Department of Urology, Medical Faculty, Trakya University, Edirne, Turkey.
authors.forename: Ersan
authors.initials: E
authors.lastname: Arda
authors.affiliation: Department of Urology, Medical Faculty, Trakya University, Edirne, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Aktoz
authors.affiliation: Department of Biostatistics, Medical Faculty, Trakya University, Edirne, Turkey.
authors.forename: Fatma Nesrin
authors.initials: FN
authors.lastname: Turan
authors.affiliation: Department of Internal Medicine and Angiology, Wuppertal Research and Medical Center, Wuppertal, Germany.
authors.forename: Kamil Mehmet
authors.initials: KM
authors.lastname: Burgazli
keywords: Acupuncture; Oligonol; Pain; Prostatitis; Rats; Therapy