title: Chordoid glioma: a rare radiologically, histologically, and clinically mystifying lesion.
abstract: Chordoid glioma (CG) is a rare central nervous system neoplasm (WHO grade II) of uncertain origin whose typical localization is in the anterior part of the third ventricle. Its clinical, radiological, and histological features may vary and furthermore mimic other kind of benign lesions usually associated with a better outcome. We report a case of a 43-year-old female who underwent gross total removal of a lesion of the third ventricle causing hydrocephalus. The imaging studies and the intraoperative examination led at first to a hypothesis of meningioma. Early surgical and neurological outcomes were good. The patient underwent multiple complications related to hypothalamic dysfunctions and thrombohemorragic issues and eventually died because of systemic infections. Definitive examination was of chordoid glioma of the third ventricle. Reviewing literature, we evaluated possible pitfalls in radiological and histological diagnosis as well as in surgical and medical treatment of CGs. Despite their benign presentation, a high incidence of multiple possible severe complications is reported. Early alertness and combined treatment strategies could improve overall CGs treatment strategies.
authors.affiliation: Neurosurgery, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, Piazzale Golgi 19, 27100, Pavia, Italy. danielebongetta@hotmail.com.
authors.forename: Daniele
authors.initials: D
authors.lastname: Bongetta
authors.affiliation: Neurosurgery, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Università degli Studi di Pavia, Piazzale Golgi 19, 27100, Pavia, Italy. risso67@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Risso
authors.affiliation: Unit of Pathology, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Piazzale Golgi 19, 27100, Pavia, Italy. p.morbini@smatteo.pv.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Morbini
authors.affiliation: Neurosurgery Unit, Fondazione IRCCS Policlinico S. Matteo, Piazzale Golgi 19, 27100, Pavia, Italy. butti@venus.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Butti
authors.affiliation: Neurosurgery Unit, Fondazione IRCCS Policlinico S. Matteo, Piazzale Golgi 19, 27100, Pavia, Italy. p.gaetani@smatteo.pv.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gaetani
mesh_terms: D000328:Adult; D016545:Choroid Plexus Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005910:Glioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D020542:Third Ventricle / Q000473:pathology* / Q000601:surgery