title: Post-transcriptional regulation of gene expression by Unr.
abstract: Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can vary with cell type and changing cellular conditions. Recent high-throughput analyses of RNA-protein interactions indicate that Unr binds to a large subset of cellular mRNAs, suggesting that Unr may play a wider role in translational responses to cellular signals than previously thought.
authors.affiliation: *School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
authors.forename: Swagat
authors.initials: S
authors.lastname: Ray
authors.affiliation: *School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
authors.forename: Pól Ó
authors.initials: PÓ
authors.lastname: Catnaigh
authors.affiliation: *School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.
authors.forename: Emma C
authors.initials: EC
authors.lastname: Anderson
mesh_terms: D017209:Apoptosis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008938:Mitosis / Q000235:genetics; D011485:Protein Binding; D014176:Protein Biosynthesis; D020871:RNA Stability; D016601:RNA-Binding Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: C079950:CSDE1 protein, human; D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins