title: Evaluating the effect of aging on interference resolution with time-varying complex networks analysis.
abstract: In this study we used graph theory analysis to investigate age-related reorganization of functional networks during the active maintenance of information that is interrupted by external interference. Additionally, we sought to investigate network differences before and after averaging network parameters between both maintenance and interference windows. We compared young and older adults by measuring their magnetoencephalographic recordings during an interference-based working memory task restricted to successful recognitions. Data analysis focused on the topology/temporal evolution of functional networks during both the maintenance and interference windows. We observed that: (a) Older adults require higher synchronization between cortical brain sites in order to achieve a successful recognition, (b) The main differences between age groups arise during the interference window,
authors.affiliation: Laboratory of Biological Networks, Centre for Biomedical Technology, Technical University of Madrid Madrid, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ariza
authors.affiliation: Department of Basic Psychology, Universidad Autónoma de Madrid Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Solesio-Jofre
authors.affiliation: Complex Systems Group, Technical University of Madrid Madrid, Spain ; Universidad del Rosario de Colombia Bogotá, Colombia.
authors.forename: Johann H
authors.initials: JH
authors.lastname: Martínez
authors.affiliation: CINAC, HM Puerta del Sur, Hospitales de Madrid, Móstoles, and CEU-San Pablo University Madrid, Spain ; Laboratory of Neuroimaging, Centre for Biomedical Technology Madrid, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Pineda-Pardo
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology, Madrid Spain ; Montreal Neurological Institute, McConnell Brain Imaging Centre, McGill University Montreal, Canada ; Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) Madrid, Spain.
authors.forename: Guiomar
authors.initials: G
authors.lastname: Niso
authors.affiliation: Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology, Madrid Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Maestú
authors.affiliation: Laboratory of Biological Networks, Centre for Biomedical Technology, Technical University of Madrid Madrid, Spain ; Complex Systems Group & GISC, Universidad Rey Juan Carlos Madrid, Spain.
authors.forename: Javier M
authors.initials: JM
authors.lastname: Buldú
keywords: aging effects; complex networks of the brain; functional networks; magnetoencephalography (MEG); synchronization