title: Association of lipoprotein lipase gene with coronary heart disease in Sudanese population.
abstract: Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P<0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan.
authors.affiliation: Institute of Endemic Diseases, University of Khartoum, Sudan.
authors.forename: Muzamil M
authors.initials: MM
authors.lastname: Abdel Hamid
authors.affiliation: Institute of Endemic Diseases, University of Khartoum, Sudan.
authors.forename: Safa
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Faculty of Medicine and Health Sciences, Al Neelain University, Sudan.
authors.forename: Awatif
authors.initials: A
authors.lastname: Salah
authors.affiliation: Institute of Endemic Diseases, University of Khartoum, Sudan.
authors.forename: Etayeb M A
authors.initials: EM
authors.lastname: Tyrab
authors.affiliation: Faculty of Medical Laboratory Sciences, National Ribat University, Sudan.
authors.forename: Lemya M
authors.initials: LM
authors.lastname: Yahia
authors.affiliation: Sudan Heart Center, Khartoum, Sudan.
authors.forename: Elbagire A
authors.initials: EA
authors.lastname: Elbashir
authors.affiliation: Faculty of Medical Laboratory Sciences, University of Khartoum, Sudan. Electronic address: hassanhm@uofk.edu.
authors.forename: Hassan H
authors.initials: HH
authors.lastname: Musa
mesh_terms: D016022:Case-Control Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013397:Sudan / Q000453:epidemiology
chemical_list: D008055:Lipids; D008071:Lipoprotein Lipase
keywords: Coronary heart disease; LPL gene; Lipid profile; Risk factors; Sudan