title: Green polymer chemistry: enzyme catalysis for polymer functionalization.
abstract: Enzyme catalyzed reactions are green alternative approaches to functionalize polymers compared to conventional methods. This technique is especially advantageous due to the high selectivity, high efficiency, milder reaction conditions, and recyclability of enzymes. Selected reactions can be conducted under solventless conditions without the application of metal catalysts. Hence this process is becoming more recognized in the arena of biomedical applications, as the toxicity created by solvents and metal catalyst residues can be completely avoided. In this review we will discuss fundamental aspects of chemical reactions biocatalyzed by Candida antarctica lipase B, and their application to create new functionalized polymers, including the regio- and chemoselectivity of the reactions.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, USA. ssen@uakron.edu.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Sen
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, OH 44325, USA. jpuskas@uakron.edu.
authors.forename: Judit E
authors.initials: JE
authors.lastname: Puskas
mesh_terms: D002109:Caffeic Acids / Q000737:chemistry; D002175:Candida / Q000201:enzymology* / Q000378:metabolism; D002384:Catalysis; D004951:Esterification / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism* / Q000648:ultrastructure; D008049:Lipase / Q000378:metabolism* / Q000648:ultrastructure; D011090:Polyenes / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D012833:Siloxanes / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry
chemical_list: D002109:Caffeic Acids; D005656:Fungal Proteins; D011090:Polyenes; D011108:Polymers; D011137:Polystyrenes; D012833:Siloxanes; D013438:Sulfhydryl Compounds; D014753:Vinyl Compounds; D011092:Polyethylene Glycols; C008967:polyisobutylene; D008049:Lipase; C431349:lipase B, Candida antarctica; C011566:vinyl acetate
keywords: Candida antarctica lipase B; Michael addition; chemoselectivity; enzyme catalysis; poly(ethylene glycol); polyisobutylene; polymer functionalization,; polysiloxanes; polystyrene; regioselectivity; transesterification