title: Fostering synergy between cell biology and systems biology.
abstract: In the shared pursuit of elucidating detailed mechanisms of cell function, systems biology presents a natural complement to ongoing efforts in cell biology. Systems biology aims to characterize biological systems through integrated and quantitative modeling of cellular information. The process of model building and analysis provides value through synthesizing and cataloging information about cells and molecules, predicting mechanisms and identifying generalizable themes, generating hypotheses and guiding experimental design, and highlighting knowledge gaps and refining understanding. In turn, incorporating domain expertise and experimental data is crucial for building towards whole cell models. An iterative cycle of interaction between cell and systems biologists advances the goals of both fields and establishes a framework for mechanistic understanding of the genome-to-phenome relationship.
authors.affiliation: Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Eddy
authors.affiliation: Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA.
authors.forename: Cory C
authors.initials: CC
authors.lastname: Funk
authors.affiliation: Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA 98109, USA. Electronic address: nprice@systemsbiology.org.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Price
mesh_terms: D000818:Animals; D003585:Cell Biology / Q000639:trends; D016678:Genome; D006801:Humans; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods* / Q000639:trends
keywords: cell biology; data integration; modeling; networks; systems biology