title: Encapsulating Ionic Liquid and Fe₃O₄ Nanoparticles in Gelatin Microcapsules as Microwave Susceptible Agent for MR Imaging-guided Tumor Thermotherapy.
abstract: The combination of therapies and monitoring the treatment process has become a new concept in cancer therapy. Herein, gelatin-based microcapsules have been first reported to be used as microwave (MW) susceptible agent and magnetic resonance (MR) imaging contrast agent for cancer MW thermotherapy. Using the simple coacervation methods, ionic liquid (IL) and Fe3O4 nanoparticles (NPs) were wrapped in microcapsules, and these microcapsules showed good heating efficacy in vitro under MW irradiation. The results of cell tests indicated that gelatin/IL@Fe3O4 microcapsules possessed excellent compatibility in physiological environments, and they could effectively kill cancer cells with exposure to MW. The ICR mice bearing H22 tumors treated with gelatin/IL@Fe3O4 microcapsules were obtained an outstanding MW thermotherapy efficacy with 100% tumor elimination under ultralow density irradiation (1.8 W/cm(2), 450 MHz). In addition, the applicability of the microcapsules as an efficient contrast agent for MR imaging in vivo was evident. Therefore, these multifunctional microcapsules have a great potential for MR imaging-guided MW thermotherapy.
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|§College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Qijun
authors.initials: Q
authors.lastname: Du
authors.affiliation: ⊥Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Tengchuang
authors.initials: T
authors.lastname: Ma
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Fu
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Tianlong
authors.initials: T
authors.lastname: Liu
authors.affiliation: §College of Materials Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: ⊥Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Shao
authors.affiliation: ⊥Department of Radiology, First Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Fangqiong
authors.initials: F
authors.lastname: Tang
authors.affiliation: ‡Laboratory of Controllable Preparation and Application of Nanomaterials, Center for Micro/nanomaterials and Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D002214:Capsules; D003287:Contrast Media / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry*; D006979:Hyperthermia, Induced / Q000379:methods*; D052578:Ionic Liquids / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D008872:Microwaves; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D011817:Rabbits
chemical_list: D002214:Capsules; D003287:Contrast Media; D052578:Ionic Liquids; D058185:Magnetite Nanoparticles; D005780:Gelatin
keywords: MR imaging-guided; MW thermotherapy; gelatin microcapsules; ionic liquid; tumor