title: [Past and present of streptococcus pyogenes: some pathogenic factors and their genetic determination].
abstract: In this review two aspects dealt with Streptococcus pyogenes--one of the leading agent responsible for infectious diseases and another related to their complications in humans worldwide--are given. In the first part of the review the comparative evaluation of laboratory diagnostic approaches and methods used in the second half of the twentieth century and molecular technologies developed during last twenty years are described. In the second part the role of the main microbial pathogenic factors as well as the data on intra- and interspecies genetic exchange with extrachromosomal genetic elements and their influence on biological properties of the pathogen are discussed. Essential for today possibilities for molecular epidemiology of streptococcal pathology approaches must be introduces in diagnostic laboratories within the country.
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
mesh_terms: D019411:Clinical Laboratory Techniques / Q000379:methods / Q000639:trends; D006801:Humans; D062069:Inventions / Q000639:trends; D017720:Molecular Epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology*; D013297:Streptococcus pyogenes / Q000472:pathogenicity / Q000502:physiology; D037521:Virulence Factors
chemical_list: D037521:Virulence Factors