title: High frequency of autonomous T-cell proliferation compatible with T-cell large granular lymphocytic leukemia in patients with cytopenia of unknown etiology.
abstract: Large granular lymphocytic leukemia/lymphoproliferative disorder (LGL-L/LPD) is a heterogeneous neoplastic disease of large granular lymphocytes and is a well-known cause of cytopenias. We aimed to reveal the incidence of LGL-L/LPD in patients with cytopenia(s) of unknown etiology (CUE). Twenty-eight patients with CUE were investigated for LGL-L/LPD. T-cell LGL leukemia (LGL-L) was diagnosed in 12 (42.9 %) patients. The frequencies of LGL-L in patients who had anemia, neutropenia, and thrombocytopenia were 9/14 (64.2 %), 11/23 (47.8 %), and 3/10 (30 %), respectively. Seventeen of the 28 patients met the criteria of idiopathic cytopenia of undetermined significance (ICUS), and LGL-L was found in six (35.3 %) of them. We conclude that LGL-L is a rather common disease in patients with CUE and ICUS. It should be considered in this patient group and investigated thoroughly.
authors.affiliation: Department of Hematology, Faculty of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.
authors.forename: Ozlen
authors.initials: O
authors.lastname: Bektas
authors.forename: Aysegul
authors.initials: A
authors.lastname: Uner
authors.forename: Seda Muruvvet
authors.initials: SM
authors.lastname: Aydin
authors.forename: Eylem
authors.initials: E
authors.lastname: Eliacik
authors.forename: Burak
authors.initials: B
authors.lastname: Uz
authors.forename: Ayse
authors.initials: A
authors.lastname: Işık
authors.forename: Ibrahim Celalettin
authors.initials: IC
authors.lastname: Haznedaroğlu
authors.forename: Hakan
authors.initials: H
authors.lastname: Goker
authors.forename: Nilgun
authors.initials: N
authors.lastname: Sayinalp
authors.forename: Salih
authors.initials: S
authors.lastname: Aksu
authors.forename: Halûk
authors.initials: H
authors.lastname: Demiroglu
authors.forename: Osman Ilhami
authors.initials: OI
authors.lastname: Ozcebe
authors.forename: Yahya
authors.initials: Y
authors.lastname: Buyukasik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult