title: Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review.
abstract: OBJECTIVE
  To provide a quantitative assessment of the association between type 2 diabetes mellitus (T2DM) and the risk of colorectal cancer (CRC).
  
  
  METHODS
  Systematic review was conducted thorough MEDLINE, EMBASE, Cochrane Library, and ISI Web of knowledge databases till 31(st) January 2014. This meta-analysis included the cohort studies that illustrated relative risk (RR) or odds ratio estimates with 95%CI for the predictive risk of CRC by T2DM. Summary relative risks with 95%CI were analyzed by using an effects summary ratio model. Heterogeneity among studies was assessed by the Cochran's Q and I (2) statistics.
  
  
  RESULTS
  The meta analysis of 8 finally selected studies showed a positive correlation of T2DM with the risk of CRC as depicted by effects summary RR of 1.21 (95%CI: 1.02-1.42). Diabetic women showed greater risk of developing CRC as their effect summary RR of 1.22 (95%CI: 1.01-49) with significant overall Z test at 5% level of significance was higher than the effect summary RR of 1.17 (95%CI: 1.00-1.37) of men showing insignificant Z test. The effect summary RR of 1.19 with 95%CI of 1.07-1.33 indicate a positive relationship between DM and increased risk of CRC with significant heterogeneity (I (2) = 92% and P-value < 0.05).
  
  
  CONCLUSIONS
  Results from this systematic review and meta-analysis report that diabetic people have an increased risk of CRC as compared to non-diabetics.
authors.affiliation: Salman Yousuf Guraya, College of Medicine, Taibah University, Almadinah Almunawwarah 41477, Saudi Arabia.
authors.forename: Salman Yousuf
authors.initials: SY
authors.lastname: Guraya
mesh_terms: D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors
keywords: Cancer statistics; Colorectal cancer; Gastrointestinal cancers; Risk ratio; Type 2 diabetes mellitus