title: The treatment of rosacea with topical ivermectin.
abstract: The treatment of rosacea is challenging because several pathophysiologic processes may be involved, including neurovascular dysregulation and alterations in innate immune status. Demodex mites may play a role in the latter mechanism. Topical ivermectin is a new therapeutic modality which demonstrates antiparasitic and anti-inflammatory properties. This article reviews published evidence related to the efficacy and safety of topical ivermectin. PubMed was utilized to search for key words "topical ivermectin", "ivermectin cream" and "rosacea". Three clinical trials were found that studied topical ivermectin as a treatment option for rosacea. Ivermectin was effective, safe and well tolerated.
authors.affiliation: Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Ali
authors.affiliation: Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. haliniamd@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Alinia
authors.affiliation: Center for Dermatology Research, Department of Dermatology; Department of Pathology; Departments of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Feldman
mesh_terms: D056810:Acaricides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000287:Administration, Topical; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008925:Mites / Q000187:drug effects; D012393:Rosacea / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome
chemical_list: D056810:Acaricides; D007559:Ivermectin
keywords: Clinical trials; Demodex; Ivermectin cream; Papulopustular rosacea; Rosacea; Topical ivermectin