title: Collagenous gastroduodenitis with recurrent gastric ulcer in 12-year-old girl.
abstract: This report describes a rare case of collagenous gastroduodenitis found in a 12-year-old Japanese girl who had recurrent hematemesis. Gastrointestinal endoscopy showed many lotus leaf-like lesions on the gastric mucosa surrounded by atrophic gastric mucosa in the antrum, with a cobblestone appearance and a scarred duodenal ulcer in the duodenal bulb. A biopsy of the gastric mucosa indicated subepithelial collagen band. The patient was treated with H2-blockers for her symptoms for 4 years following the endoscopic findings. Follow-up endoscopy showed the same appearance as before. The pathology, however, showed a more prominent subepithelial collagen deposition. To make the correct diagnosis, it is critical to know from which part the pathological biopsy specimens were taken because there were numerous collagen bands in the atrophic membrane. It is important to monitor the patient regularly for evaluation of the etiology, pathogenesis and prognosis of this rare disease.
authors.affiliation: Department of Pediatrics, Osaka Police Hospital, Osaka, Japan.|London Iryo Centre.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Koide
authors.affiliation: Department of Pediatrics, Osaka Police Hospital, Osaka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mochizuki
authors.affiliation: Endoscopy Center, Osaka Police Hospital, Osaka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kawai
authors.affiliation: Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: Kenta
authors.initials: K
authors.lastname: Yashiro
authors.affiliation: Department of Pathology, Osaka City General Hospital, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Pathology, Osaka Police Hospital, Osaka, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.affiliation: Department of Pediatrics, Osaka Police Hospital, Osaka, Japan.
authors.forename: Toshinori
authors.initials: T
authors.lastname: Nishigaki
mesh_terms: D001706:Biopsy; D002648:Child; D003094:Collagen / Q000378:metabolism*; D004382:Duodenitis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D005756:Gastritis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D012008:Recurrence; D013276:Stomach Ulcer / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D006635:Histamine H2 Antagonists; D003094:Collagen
keywords: children; collagen band; collagenous gastritis; collagenous gastroduodenitis