title: Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus.
abstract: Catharanthus roseus produces a wide range of terpenoid indole alkaloids (TIA). Many of them, such as vinblastine and vincristine, have significant bioactivity. They are valuable chemotherapy drugs used in combination with other drugs to treat lymphoma and leukemia. The TIA biosynthetic pathway has been investigated for many years, for scientific interest and for their potential in manufacturing applications, to fulfill the market demand. In this review, the progress and perspective of C. roseus TIA biosynthesis and its regulating enzymes are described. In addition, the culture condition, hormones, signaling molecules, precursor feeding on the accumulation of TIA, and gene expression are also evaluated and discussed.
authors.affiliation: Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
authors.forename: Mingxuan
authors.initials: M
authors.lastname: Wang
authors.affiliation: Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wen
authors.affiliation: Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, China ; Department of Natural Medicinal Chemistry, College of Pharmacy, Jinan University, Guangzhou 510632, China.
authors.forename: Rongmin
authors.initials: R
authors.lastname: Yu
keywords: Biosynthesis pathway; enzymes; gene expression; regulation; terpenoid indole alkaloids; vinblastine