title: Synthesis of a Functionalized Benzofuran as a Synthon for Salvianolic Acid C Analogues as Potential LDL Antioxidants.
abstract: A palladium mediated synthesis of a common synthon for the syntheses of antioxidant analogues of naturally occurring salvianolic acids is presented. The synthetic route may be used to obtain analogues with a balanced lipophilicity/hydrophilicity which may result in potentially interesting LDL antioxidants for the prevention of cardiovascular diseases.
authors.forename: Gabriela
authors.initials: G
authors.lastname: López-Frías
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Camacho-Dávila
authors.forename: David
authors.initials: D
authors.lastname: Chávez-Flores
authors.forename: Gerardo
authors.initials: G
authors.lastname: Zaragoza-Galán
authors.forename: Víctor H
authors.initials: VH
authors.lastname: Ramos-Sánchez
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008516:Medicine, Chinese Traditional; D018384:Oxidative Stress; D010165:Palladium / Q000737:chemistry; D059808:Polyphenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000475:Alkenes; D000975:Antioxidants; D001572:Benzofurans; D008077:Lipoproteins, LDL; D059808:Polyphenols; C460128:tournefolal; D010165:Palladium; C000597819:salvianolic acid C
keywords: antioxidant; benzofuran; palladium