title: Antimalarial drugs alone may still have a role in rheumatoid arthritis.
abstract: OBJECTIVE
  Antimalarials have been used for the treatment of rheumatoid arthritis (RA) for several decades. Current guidelines do not include the use of these drugs alone for RA patients. The purpose of the study is to review RA patients, to find those who have done well on antimalarials alone, and see if there are common features that predict good treatment outcome with these drugs.
  
  
  METHODS
  This is a retrospective chart review of patients who have been successfully treated with antimalarials alone. Patients who were attending routine follow-up and were seemingly in remission defined by no swollen or tender joints were selected over a 6-month period. Those who had being doing well but were now or had been on other agents were not included. The background data were reviewed to see if there were any common initial characteristics.
  
  
  RESULTS
  Thirty-three patients were seen who had been administered antimalarials alone and where initial data were available. Patients remain in clinical remission. Based on clinical observation, inflammatory markers, and radiographic reports, in the follow-up visits, they remain with no signs of inflammation and no new erosions on radiograph. Initial bone erosions on 2 patients remain stable over the years.
  
  
  CONCLUSIONS
  There are some patients with confirmed RA who without doubt respond well to antimalarials alone. It is hard to objectively measure whether mild disease activity, early treatment initiation, lack of smoking, or other factors are contributing to a good treatment response.
authors.affiliation: From the Divisions of *Internal Medicine and †Rheumatology, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: Ina
authors.initials: I
authors.lastname: Cusnir
authors.forename: Selina
authors.initials: S
authors.lastname: Dobing
authors.forename: Niall
authors.initials: N
authors.lastname: Jones
authors.forename: Anthony
authors.initials: A
authors.lastname: Russell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000962:Antimalarials / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002738:Chloroquine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D002738:Chloroquine