title: A niche role for cancer exosomes in metastasis.
abstract: Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.
authors.affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Xiao-Fan
authors.initials: XF
authors.lastname: Wang
mesh_terms: D000818:Animals; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D055354:Exosomes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D010190:Pancreatic Neoplasms / Q000473:pathology*
chemical_list: D008263:Macrophage Migration-Inhibitory Factors