title: Characteristics of Diffusion in the Corticospinal Tract of Patients with Early Stage of Schizophrenia: Diffusion Tensor Magnetic Resonance Imaging.
abstract: Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown.
authors.affiliation: Research Institute of Urgent Children Surgery and Traumatology, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Ublinskii
authors.forename: N A
authors.initials: NA
authors.lastname: Semenova
authors.forename: O V
authors.initials: OV
authors.lastname: Lukovkina
authors.forename: S V
authors.initials: SV
authors.lastname: Sidorin
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
authors.forename: A N
authors.initials: AN
authors.lastname: Barkhatova
authors.forename: T A
authors.initials: TA
authors.lastname: Akhadov
mesh_terms: D000293:Adolescent; D000328:Adult; D016880:Anisotropy; D001834:Body Water; D065850:Cerebral Peduncle / Q000378:metabolism / Q000473:pathology; D004058:Diffusion; D056324:Diffusion Tensor Imaging; D006801:Humans; D020772:Internal Capsule / Q000378:metabolism / Q000473:pathology; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism / Q000473:pathology; D009044:Motor Cortex / Q000378:metabolism / Q000473:pathology; D009412:Nerve Fibers / Q000378:metabolism / Q000473:pathology; D011712:Pyramidal Tracts / Q000378:metabolism* / Q000473:pathology; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D066127:White Matter / Q000378:metabolism / Q000473:pathology; D055815:Young Adult