title: Platinum-Incorporating Poly(N-vinylpyrrolidone)-poly(aspartic acid) Pseudoblock Copolymer Nanoparticles for Drug Delivery.
abstract: Cisplatin-incorporating pseudoblock copolymer nanoparticles with high drug loading efficiency (ca. 50%) were prepared built on host-guest inclusion complexation between β-cyclodextrin end-capped poly(N-vinylpyrrolidone) block and admantyl end-capped poly(aspartic acid) block, followed by the coordination between cisplatin and carboxyl groups in poly(aspartic acid). The host-guest interaction between the two polymer blocks was examined by two-dimensional nuclear overhauser effect spectroscopy. The size and morphology of nanoparticles formed were characterized by dynamic light scattering, zeta potential, transmission electron microscopy, and atomic force microscopy. The size control of nanoparticles was carried out by varying the ratio of poly(N-vinylpyrrolidone) to poly(aspartic acid). The nanoparticles were stable in the aqueous medium with different pH values but disintegrated in the medium containing Cl(-) ions. The in vitro and in vivo antitumor effects of cisplatin-loaded nanoparticles were evaluated. The biodistribution of the nanoparticles in vivo was studied by noninvasive near-infrared fluorescence imaging and ion-coupled plasma mass spectrometry. It was found that cisplatin-loaded nanoparticles could effectively accumulate in the tumor site and exhibited significant superior in vivo antitumor activity to the commercially available free cisplatin by combining the tumor volume, body weight, and survival rate measurements.
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Xikuang
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Weizhi
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, and Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001224:Aspartic Acid / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010316:Particle Size; D011760:Pyrrolidinones / Q000737:chemistry*; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011760:Pyrrolidinones; D001224:Aspartic Acid; C042670:N-vinyl-2-pyrrolidinone; D002945:Cisplatin