title: [Pregnancy and viral hepatitis B and C].
abstract: The screening for HBsAg is a medical obligation in France during pregnancy. A serovaccination with antiHBs immunoglobulins (100 IU) and a 1st dose of vaccine (10 μg) has to be realized during the first 12 hours of life when the mother is HBsAg+. The serovaccination failures are related to high maternal viral load (HBV-DNA>7 log IU/mL). In this case, a treatment with analogue (tenofovir) associated with serovaccination could be performed during the last trimester of pregnancy. The risk of mother-to-child transmission of virus C is around 3 to 5% in case of HCV-RNA positive without co-infection with HIV. The mode of delivery is unchanged in case of maternal HBV or HCV. Breast-feeding is not contra-indicated in case of maternal HBV or HCV infection.
authors.affiliation: Université Paris-Descartes, Sorbonne Paris Cité, France; AP-HP, hôpital Cochin, service d'hépatologie, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: philippe.sogni@cch.aphp.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sogni
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000175:diagnosis / Q000628:therapy; D006526:Hepatitis C / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000628:therapy / Q000821:virology*