title: New Metabolites from the South China Sea Sponge Diacarnus megaspinorhabdosa.
abstract: Chemical investigation on CH2Cl2 extract of the marine sponge Diacarnus megaspinorhabdosa resulted in the isolation of two new farnesylacetone derivatives 1-2, a new γ-lactone 3, a known dinorditerpenone 4 and four known norsesterterpene peroxides 5-8. Their structures were elucidated by using one and two dimensional (1D and 2D)-NMR, high resolution-electrospray ionization (HR-ESI)-MS, and comparison with the literature. Compounds 1 and 2 were cis/trans-olefinic isomers and determined through nuclear Overhauser effect spectroscopy (NOESY) experiment. The absolute configuration of 3 was established by comparison of circular dichroism (CD) data with known lactones. The cytotoxic activities of the compounds were evaluated against five cancer cell lines, and compound 3 showed moderate cytotoxicity activities against cancer cell lines HeLa, H446, NCI-H460, SGC-7901 and MCF-7, with IC50 values in the range of 18.5 to 47.1 µM.
authors.affiliation: Department of Pharmacy, Changzheng Hospital, Second Military Medical University.
authors.forename: Guang-fei
authors.initials: GF
authors.lastname: Wang
authors.forename: Rui-hua
authors.initials: RH
authors.lastname: Ji
authors.forename: Meng-xue
authors.initials: MX
authors.lastname: Cao
authors.forename: Wei-zhuo
authors.initials: WZ
authors.lastname: Tang
authors.forename: Hao-bing
authors.initials: HB
authors.lastname: Yu
authors.forename: Bin-bin
authors.initials: BB
authors.lastname: Gu
authors.forename: Li-jian
authors.initials: LJ
authors.lastname: Ding
authors.forename: Shuang
authors.initials: S
authors.lastname: Peng
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Jiao
authors.forename: Fan
authors.initials: F
authors.lastname: Sun
authors.forename: Hou-wen
authors.initials: HW
authors.lastname: Lin
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Piao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D007783:Lactones; D010545:Peroxides; D054830:Sesterterpenes; D013729:Terpenes; C014549:farnesylacetone