title: Base Mediated Synthesis of Alkyl-aryl Ethers from the Reaction of Aliphatic Alcohols and Unsymmetric Diaryliodonium Salts.
abstract: The base mediated coupling of aliphatic alcohol pronucleophiles with unsymmetric diaryliodonium salt electrophiles is described. This metal-free reaction is operationally simple, proceeds at mild temperature, and displays broad substrate scope to generate industrially important alkyl-aryl ethers in moderate to excellent yield. The synthetic utility of these reactions is demonstrated, and aspects of sustainability are highlighted by the use of unsymmetric aryl(mesityl)iodonium arylating reagents.
authors.affiliation: Department of Chemistry, Portland State University, Portland Oregon 97201, United States.
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Sundalam
authors.affiliation: Department of Chemistry, Portland State University, Portland Oregon 97201, United States.
authors.forename: David R
authors.initials: DR
authors.lastname: Stuart
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001713:Biphenyl Compounds; D004987:Ethers; D009861:Onium Compounds; C031291:diphenyliodonium