title: Comparison of therapy with Ticagrelor, Prasugrel or high Clopidogrel dose in PCI patients with high on treatment platelet reactivity and genotype variation. TRIPLETE RESET trial.
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy. Electronic address: rino.sardella@uniroma1.it.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Sardella
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Calcagno
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mancone
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Lucisano
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Pennacchi
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Rocco Edoardo
authors.initials: RE
authors.lastname: Stio
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Placentino
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Di Roma
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Cavallo
authors.affiliation: Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine & Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palmirotta
authors.affiliation: Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine & Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
authors.affiliation: Department of Cardiovascular, Respiratory, Geriatric, Anesthesiologic and Nephrologic Sciences, Umberto I Hospital, Sapienza University of Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D000068799:Prasugrel Hydrochloride / Q000008:administration & dosage*; D058921:Purinergic P2Y Receptor Antagonists / Q000008:administration & dosage*; D000077486:Ticagrelor; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D000077144:Clopidogrel; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D000068799:Prasugrel Hydrochloride; D000077486:Ticagrelor; D000241:Adenosine; D013988:Ticlopidine
keywords: Clopidogrel; Genetics; High on-treatment platelet reactivity; Prasugrel; Stable coronary artery disease; Ticagrelor