title: Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.
abstract: A diastereoselective process for the formation of intermediates suitable for the preparation of C1 substituted carbapenems was developed. The process is readily scalable and does not involve organometallics or strong bases such as LDA.
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Thu Q
authors.initials: TQ
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Weirui
authors.initials: W
authors.lastname: Chai
authors.affiliation: Hockaday School, 11600 Welch Rd, Dallas, TX 75229.
authors.forename: Jane
authors.initials: J
authors.lastname: Gu
authors.affiliation: University of Texas at Austin, Austin, TX 78712.
authors.forename: Katie
authors.initials: K
authors.lastname: Cook
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Sam
authors.initials: S
authors.lastname: Goetz
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Zach
authors.initials: Z
authors.lastname: Farni
authors.affiliation: Plano West Senior High School, 5601 W. Parker Rd, Plano, TX 75093.
authors.forename: Monica
authors.initials: M
authors.lastname: Chepuru
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Melina
authors.initials: M
authors.lastname: Cox
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Pauline
authors.initials: P
authors.lastname: Nguyen
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Hashim
authors.initials: H
authors.lastname: Raja
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Patrick
authors.initials: P
authors.lastname: Magistrado
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275.
authors.forename: Faith
authors.initials: F
authors.lastname: Michael
authors.affiliation: Department of Pharmaceutic Sciences, Western University of Health Sciences, Pomona, CA 91766.
authors.forename: Peter
authors.initials: P
authors.lastname: Oelschlaeger
authors.affiliation: Department of Chemistry, Southern Methodist University, Dallas, TX 75275 ; Center for Drug Discovery, Design, and Delivery, Dedman College, Southern Methodist University, Dallas, TX 75275.
authors.forename: John D
authors.initials: JD
authors.lastname: Buynak
keywords: Antibiotic; Carbapenem; Lewis acid; silyl enol ether; β-Lactam