title: Periappendicitis during adalimumab treatment for ileocecal Crohn's disease in a 29-year-old male.
abstract: A 29-year-old male was diagnosed with ileocolic Crohn's disease (CD) approximately 2 years ago. Adalimumab was prescribed as CD remission induction therapy. Three months after beginning adalimumab, watery diarrhea and lower abdominal pain developed. He was admitted under a diagnosis of CD exacerbation. Despite fasting and antibiotic treatment, symptoms of acute panperitonitis appeared. He was diagnosed as acute appendicitis and we performed emergency surgery for peritoneal drainage and ileocecal resection on the fifth hospital day. We diagnosed periappendicitis based on the operative findings. This is the first report of periappendicitis with CD during adalimumab treatment.
authors.affiliation: Department of Gastroenterology, Saiseikai Central Hospital, Mita, Minato-Ku, Tokyo, Japan, shinta-m@keio.jp.
authors.forename: Shinta
authors.initials: S
authors.lastname: Mizuno
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Ayumi
authors.initials: A
authors.lastname: Ogawa
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Hisamatsu
authors.forename: Shigemichi
authors.initials: S
authors.lastname: Hirose
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tsukada
mesh_terms: D000068879:Adalimumab / Q000009:adverse effects*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001064:Appendicitis / Q000139:chemically induced*; D003424:Crohn Disease / Q000188:drug therapy*; D006801:Humans; D007079:Ileitis / Q000188:drug therapy*; D008297:Male; D053706:Typhlitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D000068879:Adalimumab