title: Natural Products on Nonalcoholic Fatty Liver Disease.
abstract: Non-alcoholic fatty liver disease (NAFLD) is a chronic disorder of lipid and carbohydrate metabolism and is often associated with endoplasmic reticulum stress, energy homeostasis dysregulation, and inflammation at cellular and molecular levels. Use of currently available anti-hyperlipidemia, hypoglycemia, or anti-inflammation drugs to treat NAFLD has not achieved desirable outcomes. A growing attention thus has been paid towards natural products as an alternative means in treating NALFD. Some of the natural products apparently possess the properties of ameliorating symptoms of NAFLD through restoration of lipid and carbohydrate metabolism and energy homeostasis. Data from recent animal and human studies concerning the use of natural products in the treatment of NAFLD are analyzed, and the potential underlying mechanisms are discussed.
authors.forename: Jiao-Ya
authors.initials: JY
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhong-Ping
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Institute of Digestive Disease Shanghai University of Traditional Chinese Medicine, 725 south Wanping Road, Shanghai 200032, China. jiliver@vip.sina.com.
authors.forename: Guang
authors.initials: G
authors.lastname: Ji
mesh_terms: D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D050260:Carbohydrate Metabolism / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology
chemical_list: D001688:Biological Products; D005947:Glucose