title: State of the Science: Taxane-Induced Musculoskeletal Pain.
abstract: BACKGROUND
  Cancer survival rates are improving, but this increased survivorship is offset by persistent treatment-related symptoms. Taxane-induced musculoskeletal pain (TIMP) is 1 treatment-related symptom likely undermining cancer survivors' health-related quality of life.
  
  
  OBJECTIVE
  The specific aims of this review were to evaluate (1) the conceptual clarity of TIMP, (2) descriptions of the TIMP symptom experience, (3) contextual variables influencing TIMP, and (4) the impact of TIMP on selected outcomes.
  
  
  METHODS
  A systematic approach conducted in PubMed yielded 688 articles, and 12 articles included evaluable data related to TIMP.
  
  
  RESULTS
  On average, 2 to 4 terms signifying TIMP were used; among the terms arthralgia, myalgia, and bone pain, the range of TIMP prevalence estimates varied from 1.3% to 94%. Intensity was measured in all studies, most commonly (50% of studies) using the National Cancer Institute Common Toxicity Criteria. Contextual variables and the impact of TIMP on outcomes were addressed in only 17% and 42% of studies, respectively.
  
  
  CONCLUSIONS
  Research to date has involved inconsistent use of terms signifying TIMP. Assessment of TIMP has been largely limited to intensity, with few studies evaluating contextual variables influencing TIMP or the impact of TIMP on outcomes. More comprehensive TIMP assessment is necessary in future research.
  
  
  CONCLUSIONS
  In order to improve patient-reported outcomes in cancer care, control of treatment-related symptoms is essential. Further research about TIMP will address national priorities for generating new knowledge to advance symptom science and will be directly relevant to the care of cancer survivors undergoing taxane-based chemotherapy.
authors.affiliation: Author Affiliations: Department of Science of Nursing Care (Drs Carpenter and Otte), School of Nursing, Indiana University (Ms Davis), Indianapolis.
authors.forename: Lorie L
authors.initials: LL
authors.lastname: Davis
authors.forename: Janet S
authors.initials: JS
authors.lastname: Carpenter
authors.forename: Julie L
authors.initials: JL
authors.lastname: Otte
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D059352:Musculoskeletal Pain / Q000139:chemically induced*; D009369:Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D017741:Survivors; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane