title: Mechanistic overview of immune modulatory effects of environmental toxicants.
abstract: The immune system is an integrated organization, comprising of specific organs, cells and molecules playing a crucial role in the maintenance of health. The purpose of this paper is to give a mechanistic overview of toxic effects of various chemicals and pharmacological agents, and their interaction with the various components of the immune system that leads to modulation of the immune responses. Studies suggest that many chemical agents present in the environment like; heavy metals, agrochemicals, and various types of hydrocarbons possess immune toxicity and cause either structural, functional or compositional changes in various components of the immune system that alters immune response. There is present a complex bidirectional relationship between central nervous system (CNS) and the immune system. And receptors for neuropeptides, neurotransmitters, and hormones are located on lymphoid organs. Therefore, we are of the opinion that Endocrine Disrupting Chemicals (EDCs) present in our environment may be indirectly involved in causing immune toxicity via neuroendocrine channels, and vice versa many neurological disorders may be associated with environmental pollutants utilizing immuno-neuroendocrine pathways.
authors.forename: Haji
authors.initials: H
authors.lastname: Bahadar
authors.affiliation: Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. mohammad.abdollahi@utoronto.ca.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Faheem
authors.initials: F
authors.lastname: Maqbool
authors.forename: Maryam
authors.initials: M
authors.lastname: Baeeri
authors.forename: Kamal
authors.initials: K
authors.lastname: Niaz
mesh_terms: D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007155:Immunologic Factors / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D007155:Immunologic Factors