title: C60 fullerene prevents genotoxic effects of doxorubicin in human lymphocytes in vitro.
abstract: The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (C 60+Dox) was evaluated in vitro with comet assay using human lymphocytes. The obtained results show that the C60 fullerene prevents the toxic effect of Dox in normal cells and, thus, C60+Dox complex might be proposed for biomedical application.
authors.forename: K S
authors.initials: KS
authors.lastname: Afanasieva
authors.forename: S V
authors.initials: SV
authors.lastname: Prylutska
authors.forename: A V
authors.initials: AV
authors.lastname: Lozovik
authors.forename: K I
authors.initials: KI
authors.lastname: Bogutska
authors.forename: A V
authors.initials: AV
authors.lastname: Sivolob
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.forename: U
authors.initials: U
authors.lastname: Ritter
authors.forename: P
authors.initials: P
authors.lastname: Scharff
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D020552:Comet Assay; D053938:DNA Fragmentation / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D018625:Microscopy, Atomic Force; D009152:Mutagenicity Tests; D061251:Primary Cell Culture; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D037741:Fullerenes; D004317:Doxorubicin; C069837:fullerene C60