title: Comparison of human dental follicle cells and human periodontal ligament cells for dentin tissue regeneration.
abstract: OBJECTIVE
  To compare the odontogenic potential of human dental follicle cells (DFCs) and periodontal ligament cells (PDLCs).
  
  
  METHODS
  In vitro and in vivo characterization studies of DFCs and PDLCs were performed comparatively. DFCs and PDLCs were subcutaneously implanted into the dorsum of mice for 8 weeks after combined with treated dentin matrix scaffolds respectively.
  
  
  RESULTS
  Proteomic analysis identified 32 differentially expressed proteins in DFCs and PDLCs. Examination of the harvested grafts showed PDLCs could form the dentin-like tissues as DFCs did. However, the structure of dentin tissues generated by DFCs was more complete.
  
  
  CONCLUSIONS
  PDLCs could contribute to regenerate dentin-like tissues in the inductive microenvironment of treated dentin matrix. DFCs presented more remarkable dentinogenic capability than PDLCs did.
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|3Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|3Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Ding
authors.initials: D
authors.lastname: Bai
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|4Department of Pedodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Guo
authors.affiliation: 2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|5College of Life Science, Sichuan University, Chengdu, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zeng
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|4Department of Pedodontics, West China School of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Longqiang
authors.initials: L
authors.lastname: Yang
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Zongting
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Lian
authors.initials: L
authors.lastname: Feng
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yu
authors.affiliation: 1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.|2National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D048430:Cell Shape; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003795:Dental Sac / Q000166:cytology* / Q000648:ultrastructure; D003804:Dentin / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology; D009805:Odontogenesis / Q000235:genetics; D010513:Periodontal Ligament / Q000166:cytology* / Q000648:ultrastructure; D040901:Proteomics; D012038:Regeneration / Q000502:physiology*
chemical_list: D000954:Antigens, Surface
keywords: dental follicle cells; dentin regeneration; odontogenic differentiation; periodontal ligament cells; treated dentin matrix