title: Two patients with new granulomatous lung lesions during treatment of Crohn's disease.
abstract: Two patients with granulomatous lung lesions thought to be related to Crohn's disease (CD) are reported. Patient 1 was a 43-year-old man who was diagnosed with CD at age 11 years. He developed a fever in the 38 °C, and a chest X-ray and CT scan showed infiltrates with air bronchograms in the right upper lobe and left lingular segment. Transbronchial lung biopsy (TBLB) revealed granulomatous lesions. Patient 2 was a 76-year-old woman who was diagnosed with CD at age 44 years. Chest CT showed infiltrates and nodular shadows in both lung fields. Video-assisted thoracoscopic surgery (VATS) in June 2012 revealed granulomatous lesions. Tuberculosis, fungal infections, drug-induced lung disorder, and sarcoidosis were ruled out as a cause of the granulomatous lesions in both patients. The aetiology was thought to be CD.
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan ; Department of Respiratory Medicine, Fukuoka University Hospital, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeda
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan ; Department of Respiratory Medicine, Fukuoka University Hospital, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Akagi
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyazaki
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan ; Department of Respiratory Medicine, Fukuoka University Hospital, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kodama
authors.affiliation: Department of Surgery, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Beppu
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagahama
authors.affiliation: Department of Gastroenterology, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsui
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Hospital, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Respiratory Medicine, Fukuoka University Chikushi Hospital, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Nagata
keywords: Crohn's disease; Granulomatous lung lesions; Sarcoidosis