title: Consequences of treating false positive heparin-induced thrombocytopenia.
abstract: Identification of patients with heparin-induced thrombocytopenia is encumbered by false positive enzyme-linked immuno assay (ELISA) antibody results, therefore a serotonin release assay (SRA) is used for confirmation. Recently, several studies have demonstrated that increasing the optical density (OD) threshold (currently at 0.4) of the antibody test enhances the positive predictive value. The purpose of this study was to determine the frequency of patients who were ELISA antibody positive but SRA negative, and the costs and bleeding events associated with alternative anticoagulant treatment. We hypothesized that treating patients with a positive ELISA antibody OD value of <1.0 would result in increased cost and bleeding risk. This retrospective chart review was conducted on adult hospitalized patients from 2011 to 2013. Patients with positive ELISA antibodies (OD of 0.4-1.0) and an SRA result were included. Eighty-five patients were identified with positive antibodies (average OD of 0.66), 100 % of which were found to be SRA negative. A total of 59 patients (69 %) received alternative anticoagulants. The average duration of treatment was 3.1 days, and 4 patients (4.7 %) experienced a bleeding event. The cost of testing and laboratory monitoring was $36,346 and the cost of the alternative anticoagulants totaled $47,179. The total cost was $83,525, with an average total cost per patient of $982. This study adds to the body of literature suggesting treatment should only be initiated if the OD is one or greater. The high false positive rate caused increased cost and some bleeding events.
authors.affiliation: Department of Pharmacy, Methodist Healthcare-University Hospital, 1265 Union Avenue, Memphis, TN, 38104, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Marler
authors.affiliation: Memorial Cancer Institute, Hollywood, FL, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Unzaga
authors.affiliation: Roper St. Francis Health System, Charleston, SC, USA.
authors.forename: Sundae
authors.initials: S
authors.lastname: Stelts
authors.affiliation: Department of Pharmacy, Methodist Healthcare-University Hospital, 1265 Union Avenue, Memphis, TN, 38104, USA. carrie.oliphant@mlh.org.|Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, Memphis, TN, USA. carrie.oliphant@mlh.org.
authors.forename: Carrie S
authors.initials: CS
authors.lastname: Oliphant
mesh_terms: D000328:Adult; D003365:Costs and Cost Analysis; D005189:False Positive Reactions; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000139:chemically induced / Q000175:diagnosis / Q000191:economics / Q000628:therapy
chemical_list: D006493:Heparin
keywords: Cost; Enzyme-linked immunosorbent assay; False positive; Heparin; Thrombocytopenia