title: Novel vaccine concept based on back-boost effect in viral infection.
abstract: A novel vaccine concept is discussed based on recent evidence of a "back-boost" effect in Influenza infection. The initial immune response to the infection is imprinted through an immune memory pathway. The immune memory in the back-boost mechanism could be used in reversed order as a "forward-boost" in the proposed vaccine concept.
authors.affiliation: Univ. of Kentucky, Microbiology/Immunology, 800 Rose Street, Lexington, KY 40536, United States. Electronic address: hkohl00@uky.edu.
authors.forename: Heinz
authors.initials: H
authors.lastname: Kohler
mesh_terms: D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory; D014611:Vaccination / Q000379:methods; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: Antibody; Deceptive imprinting; HIV-1; Influenza; Vaccine; Viral infection