title: Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy.
abstract: Although pretreatment neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), and platelet-lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, and overall survival (OS) in 124 BCa patients undergoing RC. OS curves were drawn using the Kaplan-Meier method and evaluated using the log-rank test. Relationships between OS and potential confounding variables were determined using Cox's proportional hazard regression model. Decreased LMR was associated with shorter OS (P = 0.012); OS in the low PLR group was significantly longer than that in the high PLR group (P = 0.029), and NLR was not significantly associated with oncological outcomes. However, after adjusting for confounding variables, patients in the high-LMR group indicated >30% decreased mortality than the low-LMR group (hazard ratio 0.674; 95% confidence interval 0.412-0.890; P = 0.003), and PLR was not an independent predictor of OS. Our results show that preoperative LMR is a better prognostic factor in BCa patients undergoing RC, compared with NLR and PLR.
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Zhang
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Rd., Qingdao, Shandong, 266003, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
authors.forename: Fang-Ning
authors.initials: FN
authors.lastname: Wan
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Zhu
authors.affiliation: Department of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Rd., Qingdao, Shandong, 266003, People's Republic of China. slijiang999@126.com.
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Sun
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, No. 270, Dongan Rd., Shanghai, 200023, People's Republic of China. yedingwei1963@126.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China. yedingwei1963@126.com.
authors.forename: Ding-Wei
authors.initials: DW
authors.lastname: Ye
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology*; D015653:Cystectomy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D057234:Preoperative Period; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery
keywords: Bladder cancer; LMR; NLR; PLR; Prognosis; Radical cystectomy