title: [Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis].
abstract: Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
authors.affiliation: Department of Pharmacology, Zhejiang University, School of Medicine, Hangzhou 310058, China;
authors.forename: Zhi-xian
authors.initials: ZX
authors.lastname: Liu
authors.affiliation: Department of Pharmacology, Zhejiang University, School of Medicine, Hangzhou 310058, China;
authors.forename: Er-qing
authors.initials: EQ
authors.lastname: Wei
authors.affiliation: Department of Pharmacology, Zhejiang University, School of Medicine, Hangzhou 310058, China;
authors.forename: Yun-bi
authors.initials: YB
authors.lastname: Lu
mesh_terms: D015820:Cadherins; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D035683:MicroRNAs; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms; D015398:Signal Transduction; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D060449:Wnt Signaling Pathway
chemical_list: D015820:Cadherins; D035683:MicroRNAs; D014157:Transcription Factors; D016212:Transforming Growth Factor beta