title: In vivo comparison of the charge densities required to evoke motor responses using novel annular penetrating microelectrodes.
abstract: Electrodes for cortical stimulation need to deliver current to neural tissue effectively and safely. We have developed electrodes with a novel annular geometry for use in cortical visual prostheses. Here, we explore a critical question on the ideal annulus height to ensure electrical stimulation will be safe and effective. We implanted single electrodes into the motor cortex of anesthetized rats and measured the current required to evoke a motor response to stimulation, and the charge injection capacity (CIC) of the electrodes. We compared platinum iridium (PtIr) electrodes with different annulus heights, with and without a coating of porous titanium nitride (TiN). Threshold charge densities to evoke a motor response ranged from 12 to 36 μC.cm(-2).ph(-1). Electrodes with larger geometric surface areas (GSAs) required higher currents to evoke responses, but lower charge densities. The addition of a porous TiN coating did not significantly influence the current required to evoke a motor response. The CIC of both electrode types was significantly reduced in vivo compared with in vitro measurements. The measured CIC was 72 and 18 μC.cm(-2).ph(-1) for electrodes with and without a TiN coating, respectively. These results support the use of PtIr annular electrodes with annulus heights greater than 100 μm (GSA of 38, 000 μm(2)). However, if the electrodes are coated with porous TiN the annulus height can be reduced to 40 μm (GSA of 16,000 μm(2)).
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Electrical and Computer Systems Engineering, Monash University Clayton, VIC, Australia ; Department of Physiology, Monash University Clayton, VIC, Australia.
authors.forename: Emma K
authors.initials: EK
authors.lastname: Brunton
authors.affiliation: Department of Materials Engineering, Monash University Clayton, VIC, Australia.
authors.forename: Bjorn
authors.initials: B
authors.lastname: Winther-Jensen
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Physiology, Monash University Clayton, VIC, Australia.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Physiology, Monash University Clayton, VIC, Australia.
authors.forename: Edwin B
authors.initials: EB
authors.lastname: Yan
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Physiology, Monash University Clayton, VIC, Australia.
authors.forename: Saman
authors.initials: S
authors.lastname: Hagh Gooie
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Electrical and Computer Systems Engineering, Monash University Clayton, VIC, Australia.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Lowery
authors.affiliation: Monash Vision Group, Monash University Clayton, VIC, Australia ; Department of Physiology, Monash University Clayton, VIC, Australia.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Rajan
keywords: charge injection capacity; in vivo; microelectrodes; neural prosthesis; neural stimulation