title: Adiponectin is independently associated with NT-proBNP: The Multi-Ethnic Study of Atherosclerosis.
abstract: OBJECTIVE
  To investigate the associations between selected adipokines and the N-terminal prohormone of B-type natriuretic peptide (NT-proBNP).
  
  
  RESULTS
  As many as 1489 individuals enrolled in the Multi-Ethnic Study of Atherosclerosis were evaluated at 4 clinic visits about every 2 years. The evaluation included fasting venous blood, which was analyzed for NT-proBNP (at visits 1 and 3) and the adipokines adiponectin and leptin (at visits 2 and 3). The mean age was 64.8 ± 9.6 years and 48% were female. After multivariable adjustment, a 1-SD increment in adiponectin was associated with a 14 pg/ml higher NT-proBNP level (p < 0.01), while, compared to the 1st quartile of adiponectin, the 2nd, 3rd and 4th quartiles had 28, 45 and 67% higher NT-proBNP levels (p < 0.01 for all). For changes in NT-proBNP over the follow-up period, and after multivariable adjustment including baseline NT-proBNP, a 1-SD increment in adiponectin was associated with a 25 pg/ml absolute increase in NT-proBNP (p < 0.01), while those in the 2nd, 3rd and 4th quartiles of adiponectin were associated with increases of 5, 28 and 65 pg/ml (p = 0.74, 0.09 and <0.01, respectively). There was a significant interaction between adiponectin and sex for visit 3 NT-proBNP (p-interaction < 0.01), with significantly stronger associations in men. Leptin was not associated with NT-proBNP.
  
  
  CONCLUSIONS
  Higher adiponectin, but not leptin, is significantly associated with higher levels of NT-proBNP, as well as with greater longitudinal increases in NT-proBNP. The associations were stronger in men.
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address: mallison@ucsd.edu.
authors.forename: M A
authors.initials: MA
authors.lastname: Allison
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Criqui
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Maisel
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Daniels
authors.affiliation: Pritikin Research Foundation Los Angeles, Los Angeles, CA, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Roberts
authors.affiliation: Department of Radiology, Tufts Medical Center, Boston, MA, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Polak
authors.affiliation: Department of Pathology, University of Vermont, Burlington, VT, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cushman
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Adipokines; Ethnicity; Natriuretic