title: [Effects of Lonicera Japonica flavone on immunomodulation in mice].
abstract: OBJECTIVE
  To study immunomodulating activity of Lonicera Japonica flavone by investigating immune enzymatic activity of serum and antoxidized activity of lymphoid organs in mice.
  
  
  METHODS
  Fifty KM mice were randomly divided into control group, model group, low dose group, middle dose group and high dose group(n = 10), respectively. And low dose group, middle dose group and high dose group were given Lonicera Japonica flavone with 100 mg/kg, 200 mg/kg and 400 mg/kg every day, respectively, while control group and model group were administered with NS. After continuously giving drug 7 weeks, other groups were injected with Dexamethasome (Dex: 25 mg /kg) for 3 days by subcutaneous injection, but the control group were treated with NS. And after giving Lonicera Japonica flavone 1 week simultaneously, organ indexes , the activity of acid phosphatase (ACP), alkaline phosphatase (AKP) and lysozyme (LSZ) in serum , and the content of monoamine oxidase (MAO), total antioxidant capacity (T-AOC), total superoxide dismutase (SOD) and malondialdehyde (MDA) in lymphoid organs in mice were tested, respectively.
  
  
  RESULTS
  Lonicera Japonica flavone could significantly improve the organ indexes, and significantly improve the activity of ACP, AKP and LSZ in serum, and significantly improve the contents of T-AOC and SOD, but reduce that of MAO and MDA in lymphoid organs in immunosuppressed mice.
  
  
  CONCLUSIONS
  Ionicera Japonica flavone can significantly improve the activity of immune enzyme in serum and the antioxidized activity of lymphoid organs in mice. It suggests that Ionicera Japonica flavone has a good immunomodulatory effects.
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Pi
authors.forename: Juan
authors.initials: J
authors.lastname: Tan
authors.forename: Zhao-tun
authors.initials: ZT
authors.lastname: Hu
authors.forename: De-biao
authors.initials: DB
authors.lastname: Xiang
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D047309:Flavones / Q000494:pharmacology*; D056747:Immunomodulation; D031239:Lonicera / Q000737:chemistry*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009113:Muramidase / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D047309:Flavones; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D009113:Muramidase