title: [Effect of spinal manipulation on brain functional activity in patients with lumbar disc herniation].
abstract: To investigate the effects of spinal manipulation (SM) on brain functional activity in patients with lumbar disc herniation (LDH).
  
  
  
  Eleven patients with LDH were recruited in the study. All patients received 6 times of lumbar SM treatment and then clinical efficacy was evaluated. All patients received brain functional magnetic resonance imaging (fMRI) scans before and after SM treatment.
  
  
  
  Three subjects dropped out and 8 subjects completed the study, among whom 4 cases were effective and 4 ineffective after SM treatment. The required pressure value producing the same level (VAS 50) pain was (7.43 ± 1.47) kg and (10.53 ± 0.55) kg before and after SM treatment in effective patients(P<0.05); however, there was no significant difference in ineffective patients (P>0.05). Compared to pre-treatment level, the brain functional activity in effective patients was mainly inhibited, the inhibited areas were located in the right side of prefrontal cortex and cerebellum; while the brain functional activity was generally enhanced in ineffective patients.
  
  
  
  SM can affect the brain functional activity of patients with LDH, the inhibited areas is mainly located in prefrontal cortex and cerebellum when SM treatment is effective.
authors.affiliation: 1.Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China; 2.Institute of Traumatology & Orthopedics, Shanghai Academy of TCM, Shanghai 201203, China;
authors.forename: Wei-an
authors.initials: WA
authors.lastname: Yuan
authors.affiliation: 1.Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China; 2.Institute of Traumatology & Orthopedics, Shanghai Academy of TCM, Shanghai 201203, China;
authors.forename: Zhi-bi
authors.initials: ZB
authors.lastname: Shen
authors.affiliation: College of Computer Science and Technology, Fudan University, Shanghai 201203, China;
authors.forename: Li
authors.initials: L
authors.lastname: Xue
authors.affiliation: Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China;
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Tan
authors.affiliation: Institute of Tuina Affiliated to Shanghai Academy of TCM, Shanghai 200437, China.
authors.forename: Ying-wu
authors.initials: YW
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China;
authors.forename: Song-hua
authors.initials: SH
authors.lastname: Zhan
authors.affiliation: 1.Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China; 2.Institute of Traumatology & Orthopedics, Shanghai Academy of TCM, Shanghai 201203, China;
authors.forename: Hong-sheng
authors.initials: HS
authors.lastname: Zhan
mesh_terms: D001921:Brain / Q000503:physiopathology*; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000628:therapy*; D008159:Lumbar Vertebrae / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D020393:Manipulation, Spinal