title: Effect of total splenectomy in the lipid profile in mice.
abstract: OBJECTIVE
  To analyze total splenectomy effect on the lipid profile - total cholesterol, low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), very-low-density lipoprotein cholesterol (VLDL) and triglycerides levels, in Balb/c mice.
  
  
  METHODS
  Thirty Balb/c male mice, one (1) month old and average weight 26.2g ± 4.0 were used in the experiment. They were distributed into three groups of 10 animals each: a control group (non-operated), a simulation group (spleen manipulation) and the splenectomy group. The animals were subjected to blood sampling to measure plasma lipid levels, at three different times: before surgery, days 30 and 75 of the experiment.
  
  
  RESULTS
  Increased total cholesterol and LDL were observed in the control group from the start to end of the experiment. The simulation group showed increased rates of VLDL and triglycerides at the 30th and 75th days. Splenectomized animals showed no significant change.
  
  
  CONCLUSIONS
  Total splenectomy did not induce increased plasma lipids levels of in Balb/c mice.
authors.affiliation: College of Health Sciences, EMESCAM, Vitoria, ES, Brazil.
authors.forename: Bianca Lacerda
authors.initials: BL
authors.lastname: Demuner
authors.affiliation: College of Health Sciences, EMESCAM, Vitoria, ES, Brazil.
authors.forename: Gotardo Zini
authors.initials: GZ
authors.lastname: Pinho
authors.affiliation: College of Health Sciences, EMESCAM, Vitoria, ES, Brazil.
authors.forename: João Cunha
authors.initials: JC
authors.lastname: Thomaz
authors.affiliation: Federal University of Espirito Santo, Vitoria, ES, Brazil.
authors.forename: Nataly Pescinalli
authors.initials: NP
authors.lastname: Stegmiller
authors.affiliation: College of Health Sciences, EMESCAM, Vitoria, ES, Brazil.
authors.forename: Roberta Miranda de Araújo
authors.initials: RM
authors.lastname: Mendes
authors.affiliation: Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Marcela Souza Lima
authors.initials: MS
authors.lastname: Paulo
authors.affiliation: College of Health Sciences, EMESCAM, Vitoria, ES, Brazil.
authors.forename: Danilo Nagib Salomão
authors.initials: DN
authors.lastname: Paulo
mesh_terms: D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D008297:Male; D051379:Mice; D011184:Postoperative Period; D012016:Reference Values; D013154:Spleen / Q000601:surgery*; D013156:Splenectomy / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D002784:Cholesterol