title: ACE: accurate correction of errors using K-mer tries.
abstract: The quality of high-throughput next-generation sequencing data significantly influences the performance and memory consumption of assembly and mapping algorithms. The most ubiquitous platform, Illumina, mainly suffers from substitution errors. We have developed a tool, ACE, based on K-mer tries to correct such errors. On real MiSeq and HiSeq Illumina archives, ACE yields higher gains in terms of coverage depth, outperforming state-of-the-art competitors in the majority of cases.
  
  
  METHODS
  ACE is licensed under the GPL license and can be freely obtained at https://github.com/sheikhizadeh/ACE/. The program is implemented in C++ and runs on most Unix-derived operating systems.
  
  
  BACKGROUND
  siavash.sheikhizadehanari@wur.nl
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Bioinformatics Group, Wageningen University, 6700 AP Wageningen, The Netherlands.
authors.forename: Siavash
authors.initials: S
authors.lastname: Sheikhizadeh
authors.affiliation: Bioinformatics Group, Wageningen University, 6700 AP Wageningen, The Netherlands.
authors.forename: Dick
authors.initials: D
authors.lastname: de Ridder
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods* / Q000592:standards*; D012984:Software