title: Non-injected illicit drug use and infectious disease risk of donor tissue: a single institution retrospective review.
abstract: This study assessed the relationship of non-injected illicit drug use and infectious disease seropositivity for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis. In a retrospective review of 986 donor charts recovered from 2009 to 2011 at a single tissue bank, the absence of reported non-injected illicit drug use corresponded with seropositivity in 6.61 %, of recovered donors while reported illicit drug use in the medical and social history corresponded with seropositivity in 11.25 %, representing a 70 % increased risk. There was no significant difference noted for overall seropositivity rates between types on noninjected illicit drugs, although donors that used cocaine had a higher incidence of HIV, while marijuana use was associated with a higher rate of HBV, HCV, and syphilis positivity. Toxicology screening results were not an accurate predictor of seropositivity (PPV = 3.77 %; NPV = 91.56 %). Further, the degree of relationship between the donor and the next of kin had no bearing on the veracity of actual drug use when comparing the response of the medical-social history and the toxicology screen.
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL, 33136, USA. mbarton@med.miami.edu.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Barton
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Qureshi
authors.affiliation: St. George's University School of Medicine, St. George's, Grenada.
authors.forename: Anita
authors.initials: A
authors.lastname: Vijapura
authors.affiliation: University of Miami Miller School of Medicine, Miami, FL, 33136, USA.|University of Miami Tissue Bank, Miami, FL, USA.
authors.forename: H Thomas
authors.initials: HT
authors.lastname: Temple
mesh_terms: D000328:Adult; D005431:Florida / Q000453:epidemiology; D006679:HIV Seropositivity / Q000453:epidemiology; D006801:Humans; D013287:Illicit Drugs; D015994:Incidence; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D019966:Substance-Related Disorders / Q000453:epidemiology*; D013587:Syphilis / Q000453:epidemiology*; D014015:Tissue Banks / Q000706:statistics & numerical data*; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014777:Virus Diseases / Q000453:epidemiology*
chemical_list: D013287:Illicit Drugs
keywords: Illicit drug use; Seropositivity; Tissue banking