title: Soudanones A-G: Antifungal Isochromanones from the Ascomycetous Fungus Cadophora sp. Isolated from an Iron Mine.
abstract: One new isochromane (pseudoanguillosporin C, 2), seven isochromanones (soudanones A-G, 3-9), and six known analogues including 10 and 11 were isolated from a culture of the fungus Cadophora sp. 10-5-2 M, collected from the subterranean 10th level of the Soudan Underground Iron Mine in Minnesota. All of the compounds were tested against a panel of microbial pathogens, and 2, 3, 10, and 11 were found to have activity against Cryptococcus neoformans (MIC = 35, 40, 20, and 30 μg/mL, respectively). Compound 11 was also active against Candida albicans, with an MIC of 40 μg/mL.
authors.affiliation: †Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, United States.
authors.forename: Yudi
authors.initials: Y
authors.lastname: Rusman
authors.affiliation: ‡Department of Plant Pathology, University of Minnesota, Saint Paul, Minnesota 55108, United States.
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Held
authors.affiliation: ‡Department of Plant Pathology, University of Minnesota, Saint Paul, Minnesota 55108, United States.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Blanchette
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.affiliation: †Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, United States.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Salomon
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002839:Chromans; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003455:Cryptococcus neoformans / Q000187:drug effects; D007501:Iron; D008826:Microbial Sensitivity Tests; D008906:Mining; D008910:Minnesota; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000935:Antifungal Agents; D002839:Chromans; D002867:Chromones; C000601204:pseudoanguillosporin C; D007501:Iron