title: Effects of two calculolytic diets on parameters of feline mineral metabolism.
abstract: OBJECTIVE
  To evaluate the influence of two feline calculolytic diets on selected parameters of mineral metabolism.
  
  
  METHODS
  Two dry commercial diets designed for struvite urolith dissolution were evaluated in 14 cats. The study was designed as a two-sequence, four-period crossover protocol with a baseline period, two 60-day "run-in" periods in which calculolytic diets (Diet 1 and Diet 2) were fed and one 30-day "wash-out" period. Data are expressed as median (range).
  
  
  RESULTS
  Feeding the calculolytic diets for two months did not alter plasma concentrations of calcium, phosphorus, magnesium and parathyroid hormone. A significant (P < 0.05 in each case) decline in calcitriol was observed after administering both diets from 236.4 (122.4-429.6) to 170.4 (108.0-394.3) pmol/L (Diet 1) and from 278.4 (153.6-492.0) to 177.1 (87.6-392.4) pmol/L (Diet 2). Cats fed Diet 1 showed a significant increase in urine calcium concentration (from 0.3 (0.2-0.5) to 0.4 (0.3-0.7) mmol/L). Magnesium concentration in urine was significantly increased with both diets, from 1.4 (0.1-1.7) to 1.5 (1.3-2.4) mmol/L (Diet 1) and from 1.1 (0.4-1.9) to 2.0 (0.1-3.1) mmol/L (Diet 2).
  
  
  CONCLUSIONS
  Both diets resulted in an increased urinary concentration of magnesium, through different mechanisms: urine acidification (Diet 1) and increased sodium load (Diet 2).
authors.affiliation: Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Pineda
authors.affiliation: Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Aguilera-Tejero
authors.affiliation: Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain.
authors.forename: A I
authors.initials: AI
authors.lastname: Raya
authors.affiliation: Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Montes de Oca
authors.affiliation: Instituto Maimonides para la Investigacion Biomedica (IMIBIC), Hospital Reina Sofia, Universidad de Cordoba, Cordoba, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
authors.affiliation: Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Lopez
mesh_terms: D000818:Animals; D002118:Calcium / Q000652:urine; D002371:Cat Diseases / Q000097:blood / Q000178:diet therapy* / Q000652:urine; D002415:Cats / Q000378:metabolism*; D004032:Diet / Q000662:veterinary*; D005260:Female; D008274:Magnesium / Q000652:urine; D017616:Magnesium Compounds / Q000652:urine; D008297:Male; D010710:Phosphates / Q000652:urine; D000069877:Struvite; D016896:Treatment Outcome; D001744:Urinary Bladder Calculi / Q000178:diet therapy / Q000662:veterinary*
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D000069877:Struvite; D008274:Magnesium; D002118:Calcium