title: Serum and urinary biomarkers for predicting acute kidney injury after partial nephrectomy.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the ability of specific biomarkers to predict acute kidney injury (AKI) after partial nephrectomy.
  
  
  METHODS
  A prospective study of 89 patients undergoing partial nephrectomy was conducted in the First Affiliated Hospital of Fujian Medical University. The patients were divided into two groups according to AKI status: an AKI group and non-AKI group. Receiver operator characteristic (ROC) curves were generated and the areas under the curve (AUCs) were compared.
  
  
  RESULTS
  Twenty-eight subjects (31.5%) developed AKI while sixty-one subjects (68.5%) did not. Vascular clamping time in the AKI group was longer than that in the non-AKI group (29 ± 17 min vs. 24 ± 9 min, P = 0.042). Eight patients (28.6%) received blood infusion in the AKI group compared with five patients (8.2%) in the non-AKI group (P = 0.021). The area under ROC curve for AKI prediction was 0.792 [95% confidence interval (CI) 0.697 to 0.888, P < 0.000] for serum cystatin C 24 hours after surgery and 0.756 (95% CI 0.656 to 0.857, P < 0.000) for serum cystatin C 48 hours after surgery. Multivariate regression analysis showed transfusion [Hazard ratio (HR) 3.712, P = 0.044] and 24 hours serum cystatin C (HR 41.594, P = 0.001) correlated with AKI.
  
  
  CONCLUSIONS
  Postoperative serum cystatin C may be an early predictor for AKI after partial nephrectomy. Transfusion may be an independent risk factor for AKI after partial nephrectomy.
authors.affiliation: . zhuanzhuan007@126.com.
authors.forename: Jinzhuan
authors.initials: J
authors.lastname: Chen
authors.forename: Jianqing
authors.initials: J
authors.lastname: Lin
authors.forename: Caizhu
authors.initials: C
authors.lastname: Lin
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D055316:Cystatin C / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011184:Postoperative Period; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D055316:Cystatin C