title: Dyshormonogenesis seems to be more frequent in a group of Cameroonian children with congenital hypothyroidism.
abstract: Congenital hypothyroidism is a main congenital endocrine disorder, affecting 1 in 4000 births. It is not well described in sub-Saharan countries, and to draw attention to that issue, we decided to describe affected pediatric patients. We retrospectively analyzed the records of eight patients over a period of 6 years. We analyzed clinical sings of hypothyroidism and psychomotor development; hormonal assays and thyroid ultrasound were performed. We included four boys and four girls aged from 3 to 84 months at diagnosis with a median thyroid-stimulating hormone (TSH) level of 156.5 mUI/L. All except one present with a moderate psychomotor delay. Other clinical signs were classical for hypothyroidism. Thyroid ultrasound performed showed a goiter in half of patients, a normal gland in three of them and a hypoplasic gland in the last one, consonant with dyshormonogenesis. We therefore concluded that dyshormonogenesis seems to be more frequent in our context, and this raised the issue of neonatal screening of hypothyroidism in Africa.
authors.forename: Suzanne Ngo
authors.initials: SN
authors.lastname: Um Sap
authors.forename: Paul
authors.initials: P
authors.lastname: Koki
authors.forename: Felicité Nguefack
authors.initials: FN
authors.lastname: Dongmo
authors.forename: Louis
authors.initials: L
authors.lastname: De Djob
authors.forename: Annie
authors.initials: A
authors.lastname: Tedga
authors.forename: Hubert Mbassi
authors.initials: HM
authors.lastname: Awa
authors.forename: David
authors.initials: D
authors.lastname: Chelo
authors.forename: Angeline
authors.initials: A
authors.lastname: Boula
mesh_terms: D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D005260:Female; D006042:Goiter / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013972:Thyrotropin / Q000097:blood*; D014463:Ultrasonography
chemical_list: D013972:Thyrotropin