title: Efficacy and tolerability of levosulipride, domperidone and metoclopramide in patients with non-ulcer functional dyspepsia: a comparative analysis.
abstract: OBJECTIVE
  This is a prospective, randomized study designed to demonstrate the efficacy of three study drugs (Levosulpiride, Domperidone and Metoclopramide) in Functional Dyspepsia. Subject recruitment was done from medicine outpatient department of the teaching hospital from June 2013 to November 2013.
  
  
  METHODS
  The data collection was performed by the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) question instrument for assessing the dyspeptic symptoms of functional dyspepsia in patients enrolled in the study were assessed at base line (Prior to initiation of therapy) and at the next 4 weeks on a 5-point scale.
  
  
  RESULTS
  Among 120 patients 113 patients completed this study in three groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35 patients and G-3 Metoclopramide 38 patients) were followed up. Female gender was dominated (75), occupation wise most of patients belong to laborer (49) class. Highly significant improvement in symptoms scale was noticed in G-1 Levosulpiride 40 patients' group.
  
  
  CONCLUSIONS
  Functional Gastrointestinal disorders are not serious ailments but have a key impact on quality of life. overall dyspeptic symptom relief rates were significantly high in the Levosulpiride group (p<0.004) as compare to Domperidone and Metoclopramide groups. A proper understanding of disease process by health care personnel and by sufferer is obligatory to enhance the quality of life and daunting the self/over the counter medication in this condition.
authors.affiliation: Associate Professor, Department of Pharmacology, G.G.S. Medical College , Faridkot, Punjab. India .
authors.forename: Harminder
authors.initials: H
authors.lastname: Singh
authors.affiliation: 3nd year Post-graduate Resident, Department of Pharmacology, G.G.S. Medical College , Faridkot, Punjab. India .
authors.forename: Ritu
authors.initials: R
authors.lastname: Bala
authors.affiliation: Assistant Professor, Department of Pharmacology, G.G.S. Medical College , Faridkot, Punjab. India .
authors.forename: Kamalpreet
authors.initials: K
authors.lastname: Kaur
keywords: Gastrointestinal disorders; Prokinetic; Quality of life