title: [Protective effects of Qizhen Jiangtang granules in diabetic nephropathy rats].
abstract: OBJECTIVE
  To study the curative and protective effects of Qizhen Jiangtang Granules in the diabetic nephropathy (DN) model rats.
  
  
  METHODS
  Healthy SD rats were fed a high-sucrose and high-fat diet and intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) to establish the DN model. The rats were divided into six groups including normal control group,model group, positive control group, high-dosage group(200 mg/kg), medium-dosage group (100 mg/kg), and low-dosage group(50 mg/kg). After oral administration of Qizhen Jiangtang Granules for eight weeks, FBG,TG,TC, LDL-c, HDL-c, SCr and BUN levels in rats serum were determined, while the pathological damage of kidney tissue with PAS and HE staining were observed under microscope.
  
  
  RESULTS
  After treatment, TG, TC, LDL-c,SCr and BUN levels were significantly decreased(P <0. 05), and HDL-c level was significantly increased(P <0. 05). The treatment also alleviated the pathological damage of kidney tissue.
  
  
  CONCLUSIONS
  Qizhen Jiangtang Granules have a protective effect against kidney damage in DN model rats. The mechanism may be related to the regulation of lipid and sugar levels in serum.
authors.forename: Xian-chun
authors.initials: XC
authors.lastname: Duan
authors.forename: Zhao-hui
authors.initials: ZH
authors.lastname: Fang
authors.forename: Lun-zhu
authors.initials: LZ
authors.lastname: Xia
authors.forename: Xiao-chuang
authors.initials: XC
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Liang-bing
authors.initials: LB
authors.lastname: Wei
authors.forename: Yong-zhong
authors.initials: YZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D059305:Diet, High-Fat; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007668:Kidney / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
chemical_list: D004365:Drugs, Chinese Herbal; D013311:Streptozocin