title: Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Aβ Plaques in Alzheimer's Disease.
abstract: Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to Aβ plaques which is a hallmark of AD. To address this binding, we have designed a novel nanoimaging agent (NIA) based on nature-derived poly(β-l-malic acid) (PMLA) containing covalently attached gadolinium-DOTA(Gd-DOTA) and nature-derived CUR. The all-in-one agent recognizes and selectively binds to Aβ plaques and is detected by MRI. It efficiently detected Aβ plaques in human and mouse samples by an ex vivo staining. The method can be useful in clinic for safe and noninvasive diagnosis of AD.
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Rameshwar
authors.initials: R
authors.lastname: Patil
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Pallavi R
authors.initials: PR
authors.lastname: Gangalum
authors.affiliation: Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Shawn
authors.initials: S
authors.lastname: Wagner
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Jose
authors.initials: J
authors.lastname: Portilla-Arias
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Rekechenetskiy
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Bindu
authors.initials: B
authors.lastname: Konda
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Keith L
authors.initials: KL
authors.lastname: Black
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA.
authors.forename: Julia Y
authors.initials: JY
authors.lastname: Ljubimova
authors.affiliation: Nanomedicine Research Center, Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, 90048, USA. hollere@cshs.org.
authors.forename: Eggehard
authors.initials: E
authors.lastname: Holler
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D000818:Animals; D001921:Brain / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry*; D003474:Curcumin / Q000031:analogs & derivatives / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008293:Malates / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry; D058225:Plaque, Amyloid / Q000175:diagnosis*; D011108:Polymers / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D008293:Malates; D009942:Organometallic Compounds; D011108:Polymers; C121060:poly(malic acid); C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D003474:Curcumin
keywords: Alzheimer disease; curcumin; MRI; nanoimaging agent; polymalic acid