title: Chylothorax after esophagectomy for esophageal cancer: risk factors and management.
abstract: BACKGROUND
  Chylothorax is an uncommon complication of esophagectomy. It carries significant morbidity and mortality. The predisposing factors are ill-defined.
  
  
  METHODS
  We retrospectively evaluated the data of 45 patients of carcinoma esophagus who underwent esophagectomy after neoadjuvant chemoradiotherapy (NACRT) from January 2010 to July 2012 in our tertiary health care center.
  
  
  RESULTS
  Four patients (8.88 %) had chylothorax. On analysis of perioperative factors, it was found that patients with chylothorax had tumor in middle third of thoracic esophagus (100 %), shown partial response to neoadjuvant chemoradiation (NACRT) (100 %) and were associated with difficult mediastinal dissection (75 %) leading to higher blood loss requiring transfusion unlike those without chylothorax. There was no significant difference in the incidence of chylothorax following transhiatal, 3/35 = 8.57 % or transthoracic esophagectomy 1/10 = 10 % (p = 0.898). Three patients were managed by transabdominal en masse ligation of tissue between aorta and azygos vein while one patient was managed conservatively. Patients were discharged after a mean hospital stay of 15.5 days. The 30-day mortality rates in the two groups were similar (0 % vs. 4.8 %).
  
  
  CONCLUSIONS
  Difficult mediastinal dissection during esophagectomy in middle esophageal cancer may lead to thoracic duct injury. Complete response to NACRT may reduce the risk of chylothorax. Early transabdominal en masse ligation carries excellent results. Low output fistula following thoracic duct injury can be managed conservatively.
authors.affiliation: Surgical Gastroenterology Division, Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Gupta
authors.forename: Harjeet
authors.initials: H
authors.lastname: Singh
authors.forename: Saurabh
authors.initials: S
authors.lastname: Kalia
authors.forename: Rajesh
authors.initials: R
authors.lastname: Gupta
authors.forename: Rajinder
authors.initials: R
authors.lastname: Singh
authors.forename: G R
authors.initials: GR
authors.lastname: Verma
mesh_terms: D016063:Blood Loss, Surgical / Q000706:statistics & numerical data; D059186:Chemoradiotherapy, Adjuvant; D002916:Chylothorax / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D005260:Female; D006801:Humans; D015994:Incidence; D008026:Ligation; D008297:Male; D008482:Mediastinum / Q000601:surgery; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D012189:Retrospective Studies; D013897:Thoracic Duct / Q000293:injuries