title: Ribosome-inactivating and related proteins.
abstract: Ribosome-inactivating proteins (RIPs) are toxins that act as N-glycosidases (EC 3.2.2.22). They are mainly produced by plants and classified as type 1 RIPs and type 2 RIPs. There are also RIPs and RIP related proteins that cannot be grouped into the classical type 1 and type 2 RIPs because of their different sizes, structures or functions. In addition, there is still not a uniform nomenclature or classification existing for RIPs. In this review, we give the current status of all known plant RIPs and we make a suggestion about how to unify those RIPs and RIP related proteins that cannot be classified as type 1 or type 2 RIPs.
authors.affiliation: Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luise-Str. 2 + 4, 14195 Berlin, Germany. joachim.schrot@fu-berlin.de.
authors.forename: Joachim
authors.initials: J
authors.lastname: Schrot
authors.affiliation: Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luise-Str. 2 + 4, 14195 Berlin, Germany. alexander.weng@fu-berlin.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Weng
authors.affiliation: Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luise-Str. 2 + 4, 14195 Berlin, Germany. melzig@zedat.fu-berlin.de.
authors.forename: Matthias F
authors.initials: MF
authors.lastname: Melzig
mesh_terms: D019684:Magnoliopsida / Q000378:metabolism; D054788:Ribosome Inactivating Proteins / Q000145:classification / Q000378:metabolism
chemical_list: D054788:Ribosome Inactivating Proteins
keywords: N-glycosidase; RIP 1; RIP 2; RIPs; classification of RIPs; nomenclature of RIPs; ribosome-inactivating proteins; type 1 RIP; type 2 RIP