title: Parkinson's disease-related spatial covariance pattern identified with resting-state functional MRI.
abstract: In this study, we sought to identify a disease-related spatial covariance pattern of spontaneous neural activity in Parkinson's disease using resting-state functional magnetic resonance imaging (MRI). Time-series data were acquired in 58 patients with early to moderate stage Parkinson's disease and 54 healthy controls, and analyzed by Scaled Subprofile Model Principal Component Analysis toolbox. A split-sample analysis was also performed in a derivation sample of 28 patients and 28 control subjects and validated in a prospective testing sample of 30 patients and 26 control subjects. The topographic pattern of neural activity in Parkinson's disease was characterized by decreased activity in the striatum, supplementary motor area, middle frontal gyrus, and occipital cortex, and increased activity in the thalamus, cerebellum, precuneus, superior parietal lobule, and temporal cortex. Pattern expression was elevated in the patients compared with the controls, with a high accuracy (90%) to discriminate the patients from the controls. The split-sample analysis produced a similar pattern but with a lower accuracy for group discrimination in both the derivation (80%) and the validation (73%) samples. Our results showed that resting-state functional MRI can be potentially useful for identification of Parkinson's disease-related spatial covariance patterns, and for differentiation of Parkinson's disease patients from healthy controls at an individual level.
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.|Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, The North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.|Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, The North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
authors.forename: Shichun
authors.initials: S
authors.lastname: Peng
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.|Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, The North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.|Beijing Key Laboratory on Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China.
authors.forename: Piu
authors.initials: P
authors.lastname: Chan
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D010296:Parietal Lobe / Q000378:metabolism; D010300:Parkinson Disease / Q000473:pathology*; D025341:Principal Component Analysis; D011446:Prospective Studies; D015203:Reproducibility of Results