title: Magnetic Resonance Imaging and Pathologic Findings of 26 Cases With Uterine Adenomatoid Tumors.
abstract: OBJECTIVE
  To analyze the magnetic resonance imaging (MRI) features and pathologic findings of uterine adenomatoid tumors (ATs) for improved diagnostic accuracy and facilitating differential diagnosis of the tumors.
  
  
  METHODS
  We investigated retrospectively 26 patients with uterine ATs confirmed by pathology. Before operation, all patients accepted multiple MRI scans, including T1-weighted image (T1WI), T2-weighted image (T2WI), T2WI/spectrally adiabatic inversion recovery, and T1-weighted enhanced imaging. Two radiologists reviewed all the MRI sequences on PACS workstations for all patients to evaluate the location, shape, size, margin, intensity, and enhancement of ATs.
  
  
  RESULTS
  All uterine ATs exhibited either single round solid (n = 24) or predominantly cystic (n = 2) masses with either well-defined (n = 23) or ill-defined margin (n = 3). The diameter range of the tumors was 1.0 to 7.0 cm (mean, 3.8 cm). Solid masses were isointensive on T1WI and hypointensive on T2WI with moderate enhancement. The degree of enhancement in solid tumors was either lower than (18/24 [75%]) or equal to (6/24 [25%]) that of the myometrium. Predominantly cystic masses presented as cystic lesions with a little irregular solid nodule inside. The cystic parts were hypointensive on T1WI and hyperintensive on T2WI without enhancement, whereas the solid nodules were isointensive on both T1WI and T2WI with moderate enhancement. A large part of the uterine ATs (69.2% [18/26]) coexisted with other uterine diseases. On pathology, uterine ATs were characterized as gland-like structures with irregular expansion of tubular cavities, which might be correlated with low enhancement of tumors. The tumors were lined with flat or cuboidal mesothelial cells and residue of smooth muscle component, which might contribute to their hypointensive appearance on T2WI.
  
  
  CONCLUSIONS
  Small solid uterine masses with homogeneous hypointensity on T2WI and lower enhancement or cystic lesions with inner irregular solid nodule may indicate the diagnosis of uterine ATs, and final diagnosis can be determined with pathology.
authors.affiliation: From the *Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China; †Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China; ‡Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, PR China; and §Department of Pathology. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, PR China.
authors.forename: Qiuhua
authors.initials: Q
authors.lastname: Meng
authors.forename: Qingsi
authors.initials: Q
authors.lastname: Zeng
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Wu
authors.forename: Qi
authors.initials: Q
authors.lastname: Wan
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Lei
authors.forename: Ting
authors.initials: T
authors.lastname: Song
authors.forename: Xia
authors.initials: X
authors.lastname: Gu
authors.forename: Guobing
authors.initials: G
authors.lastname: Hong
authors.forename: Wenhao
authors.initials: W
authors.lastname: Zhang
authors.forename: Xinchun
authors.initials: X
authors.lastname: Li
mesh_terms: D018254:Adenomatoid Tumor / Q000473:pathology*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015588:Observer Variation; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000473:pathology; D055815:Young Adult