title: Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide.
abstract: A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.
authors.affiliation: Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA. gjboons@ccrc.uga.edu.
authors.forename: Pamela
authors.initials: P
authors.lastname: Thompson
authors.forename: Vani
authors.initials: V
authors.lastname: Lakshminarayanan
authors.forename: Nitin T
authors.initials: NT
authors.lastname: Supekar
authors.forename: Judy M
authors.initials: JM
authors.lastname: Bradley
authors.forename: Peter A
authors.initials: PA
authors.lastname: Cohen
authors.forename: Margreet A
authors.initials: MA
authors.lastname: Wolfert
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Gendler
authors.forename: Geert-Jan
authors.initials: GJ
authors.lastname: Boons
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D060326:Chemistry Techniques, Synthetic; D006020:Glycopeptides / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D018396:Mucin-1 / Q000737:chemistry*; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000276:immunology*
chemical_list: D006020:Glycopeptides; D018396:Mucin-1; D014614:Vaccines, Synthetic; D019158:N-Acetylneuraminic Acid