title: TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting.
abstract: We hypothesised that the genetic effect of single nucleotide polymorphisms in the TACR1 gene, which encodes NK1 receptors, could influence the sex difference in postoperative nausea and vomiting. Thirty-two selected single nucleotide polymorphisms were genotyped by the Sanger sequencing method in 200 patients who underwent lower abdominal surgery. The incidence and severity of postoperative nausea and vomiting were evaluated after surgery. The rs3755468-SNP showed significant association with the incidence and severity of postoperative nausea and vomiting (p = 0.016). The TT haplotype defined by two single nucleotide polymorphisms, including the rs3755468-SNP, was associated with reduced incidence and severity of postoperative nausea and vomiting in female patients (p = 0.03). The rs3755468-SNP is located within the predicted oestrogen response element and a DNase I hypersensitive site. The single nucleotide polymorphisms in the TACR1 gene are associated with sex differences in postoperative nausea and vomiting and may help to elucidate the mechanisms underlying these differences.
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayase
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sugino
authors.affiliation: Department of Pharmacy, Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Moriya
authors.affiliation: Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamakage
mesh_terms: D000008:Abdominal Neoplasms / Q000601:surgery; D000328:Adult; D000368:Aged; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020250:Postoperative Nausea and Vomiting / Q000235:genetics* / Q000503:physiopathology; D018040:Receptors, Neurokinin-1 / Q000235:genetics*; D012727:Sex Characteristics
chemical_list: D018040:Receptors, Neurokinin-1