title: Hippocampal complex atrophy in poststroke and mild cognitive impairment.
abstract: To investigate putative interacting or distinct pathways for hippocampal complex substructure (HCS) atrophy and cognitive affection in early-stage Alzheimer's disease (AD) and cerebrovascular disease (CVD), we recruited healthy controls, patients with mild cognitive impairment (MCI) and poststroke patients. HCSs were segmented, and quantitative white-matter hyperintensity (WMH) load and cerebrospinal fluid (CSF) amyloid-β concentrations were determined. The WMH load was higher poststroke. All examined HCSs were smaller in amyloid-positive MCI than in controls, and the subicular regions were smaller poststroke. Memory was reduced in amyloid-positive MCI, and psychomotor speed and executive function were reduced in poststroke and amyloid-positive MCI. Size of several HCS correlated with WMH load poststroke and with CSF amyloid-β concentrations in MCI. In poststroke and amyloid-positive MCI, neuropsychological function correlated with WMH load and hippocampal volume. There are similar patterns of HCS atrophy in CVD and early-stage AD, but different HCS associations with WMH and CSF biomarkers. WMHs add to hippocampal atrophy and the archetypal AD deficit delayed recall. In line with mounting evidence of a mechanistic link between primary AD pathology and CVD, these additive effects suggest interacting pathologic processes.
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
authors.forename: Per
authors.initials: P
authors.lastname: Selnes
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Ramune
authors.initials: R
authors.lastname: Grambaite
authors.affiliation: Department of Artificial Intelligence, UNED, Madrid, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Rincon
authors.affiliation: The Intervention Centre, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Atle
authors.initials: A
authors.lastname: Bjørnerud
authors.affiliation: Department of Neurology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Leif
authors.initials: L
authors.lastname: Gjerstad
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.|Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Erik
authors.initials: E
authors.lastname: Hessen
authors.affiliation: Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.|Department of Geriatric Psychiatry, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Eirik
authors.initials: E
authors.lastname: Auning
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Johansen
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
authors.forename: Ina S
authors.initials: IS
authors.lastname: Almdahl
authors.affiliation: Department of Radiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
authors.forename: Paulina
authors.initials: P
authors.lastname: Due-Tønnessen
authors.affiliation: Department of Radiology, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Kjetil
authors.initials: K
authors.lastname: Vegge
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
authors.forename: Börje
authors.initials: B
authors.lastname: Bjelke
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway.|Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
authors.forename: Tormod
authors.initials: T
authors.lastname: Fladby
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D001284:Atrophy; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000523:psychology; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D011930:Reaction Time; D020521:Stroke / Q000473:pathology* / Q000523:psychology*; D066127:White Matter / Q000473:pathology; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins