title: Epiglottic Squamous Cell Carcinoma Showing Unexpected 18F-FDOPA Uptake on PET/CT Investigation.
abstract: We report the unexpected findings of ¹⁸F-fluorodihydroxyphenylalanine (¹⁸F-FDOPA) PET/CT performed in a patient with a history of ileal carcinoid. A focally increased ¹⁸F-FDOPA uptake was detected in the left side of the epiglottis corresponding to a laryngeal squamous cell carcinoma. Interestingly, uptake of 3-O-methyl-6-¹⁸F-fluoro-L-dihydroxyphenylalanine, a metabolite of ¹⁸F-FDOPA, has been previously reported in both squamous cell carcinoma cell lines and the corresponding mouse tumor xenograft models. Although ¹⁸F-FDOPA is mainly used in patients with neuroendocrine tumors, ¹⁸F-FDOPA is not a neuroendocrine tumor-specific radiotracer.
authors.affiliation: From the Departments of *Biophysics and Nuclear Medicine, †Otolaryngology and Maxillofacial Surgery, and ‡Pathology, University Hospitals of Strasbourg; and §ICube, University of Strasbourg/CNRS (UMR 7357) and FMTS, Faculty of Medicine, Strasbourg, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Dietemann
authors.forename: Christian
authors.initials: C
authors.lastname: Debry
authors.forename: Aline
authors.initials: A
authors.lastname: Onea
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004825:Epiglottis / Q000000981:diagnostic imaging* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging*; D006801:Humans; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D000077195:Squamous Cell Carcinoma of Head and Neck; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine