title: Copper-promoted synthesis of 1,4-benzodiazepinones via alkene diamination.
abstract: A new method for the synthesis of 2-aminomethyl functionalized 1,4-benzodiazepin-5-ones is presented. The benzodiazepine core is well-known to interact with biological receptors and many pharmaceutical drugs are derived from this structure. The alkene diamination strategy is employed for the first time for the synthesis of 1,4-benzodiazepinones. In this reaction, copper(2-ethylhexanoate)2serves as promoter and a range of external amines can be coupled with 2-sulfonamido-N-allyl benzamides to generate the 1,4-benzodiazepinones in good yields.
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Shuklendu D
authors.initials: SD
authors.lastname: Karyakarte
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Fatima C
authors.initials: FC
authors.lastname: Sequeira
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Garrick H
authors.initials: GH
authors.lastname: Zibreg
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Guoqing
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Josiah P
authors.initials: JP
authors.lastname: Matthew
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Marina M M
authors.initials: MM
authors.lastname: Ferreira
authors.affiliation: Department of Chemistry, State University of New York at Buffalo, Buffalo, New York 14260, USA, Tel: 716-645-4225;
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Chemler
keywords: 1, 4-benzodiazepinones; alkenes; copper-promoted; diamination