title: Ribavirin Reduces Absolute Lymphocyte Counts in Hepatitis C Virus-Infected Patients Treated With Interferon-Free, Direct-Acting Antiviral Regimens.
abstract: In clinical trials of interferon-free, direct-acting antiviral treatment of chronic hepatitis C, subjects who received ribavirin had reduced lymphocyte levels (median decline of approximately 0.4-0.5 × 10(9) cells/L). A modest decline in CD4(+) T cells was observed in subjects with human immunodeficiency virus type 1 coinfection without documented opportunistic infections.
authors.affiliation: Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Harrington
authors.affiliation: Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
authors.forename: Russell
authors.initials: R
authors.lastname: Fleischer
authors.affiliation: Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Connelly
authors.affiliation: Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
authors.forename: Linda L
authors.initials: LL
authors.lastname: Lewis
authors.affiliation: Division of Antiviral Products, Office of Antimicrobial Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Murray
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D008231:Lymphopenia / Q000139:chemically induced*; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin
keywords: HCV; direct-acting antiviral agents; lymphocytes; ribavirin