title: Cerebral Lymphoma in a Kidney Transplant: A Case Report.
abstract: Posttransplant lymphoproliferative disorder is a serious complication during a solid-organ transplant. A 28-year-old Asiatic man developed a cerebral lesion that was considered an abscess, while undergoing a kidney transplant. The lesion diameter did not go down with antibiotic therapy, so he underwent a complete surgical mass excision. Pathology showed a B-cell lymphoma. The Epstein-Barr virus-DNA by polymerase chain reaction in plasma was negative. He began chemotherapy with methotrexate and rituximab, and radiation therapy. He had to be restarted on regular hemodialysis 1 year after surgery. Three years after receiving the diagnosis, he was alive and had not developed any other posttransplant lymphoproliferative disorder. This report presents case of a patient who developed primary central nervous system B-cell lymphoma, 2 years after undergoing a kidney transplant. A combination of chemotherapy and radiotherapy is the best option for treatment of brain posttransplant lymphoproliferative disorder.
authors.forename: Nicola
authors.initials: N
authors.lastname: Guglielmo
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Levi Sandri
authors.forename: Fabio
authors.initials: F
authors.lastname: Melandro
authors.forename: Manuela
authors.initials: M
authors.lastname: Garofalo
authors.forename: Luca
authors.initials: L
authors.lastname: Poli
authors.forename: Pasquale  Bartolomeo
authors.initials: P
authors.lastname: Berloco
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology* / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000628:therapy; D008297:Male; D011183:Postoperative Complications