title: Serum sclerostin is decreased following vitamin D treatment in young vitamin D-deficient female adults.
abstract: Sclerostin is produced almost exclusively by osteocytes, which also express receptors for 1,25 dihydroxyvitamin D3. The aim of this study was to investigate the effects of vitamin D3 treatment on serum sclerostin levels in young adult females with severe vitamin D deficiency. A total of 26 subjects were treated orally with calcium (1.200 mg/day for 2 months) and vitamin D3 (300.000 IU/week for 1 month). Serum 25-hydroxyvitamin D (25(OH)D) and sclerostin levels were measured before and after treatment. Baseline serum 25(OH)D and sclerostin levels were at 5.7 ± 2.4 ng/mL and 39.1 ± 14.4 pg/mL, respectively. Serum 25(OH)D was significantly increased, to 62.4 ± 18.7 ng/mL, following treatment; serum sclerostin was significantly decreased, to 29.3 ± 8.8 pg/mL. We conclude that serum sclerostin level is decreased following vitamin D3 treatment in patients with vitamin D deficiency.
authors.affiliation: Physical Medicine and Rehabilitation Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Muharrem
authors.initials: M
authors.lastname: Cidem
authors.affiliation: Physical Medicine and Rehabilitation Department, Bagcilar Training and Research Hospital, İstanbul, Turkey. ilhankaracan@hotmail.com.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Karacan
authors.affiliation: Physical Medicine and Rehabilitation Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Neval Bozok
authors.initials: NB
authors.lastname: Arat
authors.affiliation: Biochemistry Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Oguzhan
authors.initials: O
authors.lastname: Zengi
authors.affiliation: Physical Medicine and Rehabilitation Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ozkaya
authors.affiliation: Biochemistry Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Saadet Pilten
authors.initials: SP
authors.lastname: Guzel
authors.affiliation: Physical Medicine and Rehabilitation Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Cansu
authors.initials: C
authors.lastname: Ozkan
authors.affiliation: Orthopaedics and Traumatology Department, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Beytemur
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D002118:Calcium / Q000627:therapeutic use*; D002762:Cholecalciferol / Q000627:therapeutic use*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D014808:Vitamin D Deficiency / Q000097:blood* / Q000188:drug therapy*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human; D002762:Cholecalciferol; D002118:Calcium
keywords: 25-Hydroxyvitamin D; Osteomalacia; Sclerostin