title: Preoperative Leucocytosis, Thrombocytosis and Anemia as Potential Prognostic Factors in Non-metastatic Renal Cell Carcinoma.
abstract: BACKGROUND
  To validate the potential prognostic significance of preoperatively assessed inflammatory parameters leucocytosis, thrombocytosis and anemia in patients with non-metastatic renal cell carcinoma (RCC).
  
  
  METHODS
  We retrospectively evaluated a cohort comprising 736 consecutive patients with non-metastatic RCC, operated on between 2004 and 2012 with curative radical or partial nephrectomy at a single tertiary academic centre. Laboratory parameters were assessed within one week before surgical intervention. Patients were categorized using laboratory parameter cut-off values according to receiver operating characteristics (ROC) analyses. Cancer-specific survival (CSS) was assessed using the Kaplan-Meier method. To evaluate the potential prognostic significance of the preoperative laboratory parameters, multivariate Cox regression models were applied.
  
  
  RESULTS
  Multivariable analysis identified preoperative thrombocytosis (≥285,000/μl) as an independent prognostic factor for CSS (Hazard ratio=2.28, 95% confidence interval=1.24-4.20, p=0.008).
  
  
  CONCLUSIONS
  Regarding CSS, an elevated preoperative platelet count represented an independent prognostic factor of poor survival. Our findings strengthen the potential prognostic significance of preoperative thrombocytosis in patients with non-metastatic RCC.
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria g.hutterer@gmail.com.
authors.forename: Georg C
authors.initials: GC
authors.lastname: Hutterer
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Krieger
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria.
authors.forename: Edvin
authors.initials: E
authors.lastname: Mrsic
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria.
authors.forename: Kristof
authors.initials: K
authors.lastname: Pohlmann
authors.affiliation: Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Angelika
authors.initials: A
authors.lastname: Bezan
authors.affiliation: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Stojakovic
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria.
authors.forename: Karl
authors.initials: K
authors.lastname: Pummer
authors.affiliation: Department of Urology, Medical University of Graz, Graz, Austria.
authors.forename: Richard
authors.initials: R
authors.lastname: Zigeuner
authors.affiliation: Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.
authors.forename: Martin
authors.initials: M
authors.lastname: Pichler
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D057234:Preoperative Period; D011379:Prognosis; D016016:Proportional Hazards Models; D013922:Thrombocytosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology*
keywords: Anemia; leucocytosis; prognosis; renal cell carcinoma; thrombocytosis