title: The sactibiotic subclass of bacteriocins: an update.
abstract: The sactibiotics are a recently designated subclass of bacteriocins that contain characteristic cysteine sulphur to α -carbon linkages mediated through post-translational modifications. They are a relatively small subclass of bacteriocins compared to the most thoroughly studied lantibiotics. The sactibiotics that have been extensively studied thus far are thuricin CD, subtilosin A, thurincin H, and propionicin F. Despite their recent discovery, there have already been significant advances made in the study of sactibiotics, most notably the discovery of the narrow spectrum anti-Clostridium difficile sactibiotic, thuricin CD. In addition, scientists have gained insights into the mechanisms of action of the sactibiotic subtilosin A, which targets Listeria monocytogenes,Gardnerella vaginalis, and other pathogens. Also, the development of heterologous host systems and homologous expression and site-directed mutagenesis systems for the sactibiotic thurincin H have opened up many opportunities for further studies on this sactibiotic. These and other recent studies concerning the molecular biology, 3D structural elucidation, mode of action, self-protection mechanisms, and antimicrobial spectrum of the sactibiotic subgroup of bacteriocins are discussed in this review.
authors.affiliation: School of Microbiology, University College Cork, Ireland and Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, Ireland. 105022894@umail.ucc.ie.
authors.forename: Harsh
authors.initials: H
authors.lastname: Mathur
authors.forename: Mary C
authors.initials: MC
authors.lastname: Rea
authors.forename: Paul D
authors.initials: PD
authors.lastname: Cotter
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001430:Bacteriocins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D023061:Gene Order; D005798:Genes, Bacterial; D056726:Genetic Association Studies; D056426:Genetic Loci; D005810:Multigene Family; D010456:Peptides, Cyclic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010456:Peptides, Cyclic; C568940:thurincin H; C047828:sboA protein, Bacillus subtilis