title: Predictors of Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett's Esophagus.
abstract: The prevalence of esophageal adenocarcinoma is increasing dramatically. Barrett's esophagus remains the most well-established risk factor for the development of esophageal adenocarcinoma. There are multiple clinical, endoscopic, and pathologic factors that increase the risk of neoplastic progression to high-grade dysplasia or esophageal adenocarcinoma in Barrett's esophagus. This article reviews both risk and protective factors for neoplastic progression in patients with Barrett's esophagus.
authors.affiliation: Division of Gastroenterology, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, 7th floor, South Pavillion, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Whitson
authors.affiliation: Division of Gastroenterology, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, 7th floor, South Pavillion, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: gary.falk@uphs.upenn.edu.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Falk
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology*; D001471:Barrett Esophagus / Q000235:genetics / Q000473:pathology*; D014408:Biomarkers, Tumor; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology*; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology*; D006801:Humans; D008679:Metaplasia / Q000473:pathology; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology*; D065840:Protective Factors; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Barrett’s esophagus; Dysplasia; Esophageal adenocarcinoma; Neoplastic progression; Risk factors