title: Myrtucommulone-A Induces both Extrinsic and Intrinsic Apoptotic Pathways in Cancer Cells.
abstract: Myrtucommulone-A is the active compound derived from Myrtus communis. The molecular targets of myrtucommulone-A is widely unknown, which impedes its potential therapeutic use. In this study, we demonstrated the cytotoxicity of MC-A and its potential to induce apoptosis in cancer cells. Myrtucommulone-A was also found to be antiproliferative and strongly inhibited cancer cell migration. Eighty four apoptotic pathway genes were used to assess the effect of myrtucommulone-A on cancer cells. Myrtucommulone-A mediated an increase in apoptotic genes including Fas, FasL, Gadd45a, Tnf, Tnfsf12, Trp53, and caspase 4. The increase in myrtucommulone-A dose (25 μM versus 6.25 μM) also upregulated the expression of genes, which are involved mainly in apoptosis, regulation of apoptosis, role of mitochondria in apoptotic signaling, cytokine activity, and tumor necrosis factor signaling. Our data indicate that myrtucommulone-A could be utilized as a potential therapeutic compound with its molecular targets in apoptotic pathways.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Izgi
authors.affiliation: Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Department of Medical Biology, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Iskender
authors.affiliation: Organische Chemie II, Universität des Saarlandes, Saarbrücken, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Jauch
authors.affiliation: Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Department of Medical Biology, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Sezen
authors.affiliation: Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Department of Medical Biology, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakir
authors.affiliation: Organische Chemie II, Universität des Saarlandes, Saarbrücken, Germany.
authors.forename: Maël
authors.initials: M
authors.lastname: Charpentier
authors.affiliation: Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Department of Medical Biology, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Canatan
authors.affiliation: Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.|Department of Medical Biology, Faculty of Medicine, Erciyes University, Melikgazi, 38039, Kayseri, Turkey.
authors.forename: Cagri
authors.initials: C
authors.lastname: Sakalar
keywords: Apoptosis; Cancer; Mouse breast cancer cells; Myrtucommulone-A