title: The future of murine sepsis and trauma research models.
abstract: Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA philip.efron@surgery.ufl.edu.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Efron
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Alicia M
authors.initials: AM
authors.lastname: Mohr
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Moore
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA.
authors.forename: Lyle L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D018805:Sepsis / Q000276:immunology* / Q000473:pathology; D014947:Wounds and Injuries / Q000276:immunology* / Q000473:pathology
keywords: immunity; translation