title: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis.
abstract: The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2-3% of adults and often precedes the development of allergic rhinitis and asthma. This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here.
authors.forename: Marina
authors.initials: M
authors.lastname: Le Lamer
authors.forename: Laurence
authors.initials: L
authors.lastname: Pellerin
authors.forename: Marie
authors.initials: M
authors.lastname: Reynier
authors.forename: Laura
authors.initials: L
authors.lastname: Cau
authors.forename: Valérie
authors.initials: V
authors.lastname: Pendaries
authors.forename: Corinne
authors.initials: C
authors.lastname: Leprince
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Méchin
authors.forename: Guy
authors.initials: G
authors.lastname: Serre
authors.forename: Carle
authors.initials: C
authors.lastname: Paul
authors.forename: Michel
authors.identifier: http://orcid.org/0000-0003-3655-6329
authors.initials: M
authors.lastname: Simon
mesh_terms: D000818:Animals; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000473:pathology; D004817:Epidermis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D011506:Proteins / Q000378:metabolism*
chemical_list: D016207:Cytokines; D011506:Proteins