title: Hydrogen Bonded Squaramide-Based Foldable Module Induces Both β- and α-Turns in Hairpin Structures of α-Peptides in Water.
abstract: A novel tertiary squaramido-based reverse-turn module SQ is reported, and its conformational properties are evaluated. This module is easily incorporated into a α-peptide sequence by conventional solid-phase peptide synthesis. The structure characterization of the hybrid squaramido-peptide 4 is described, showing that the turn segment induces the formation of hairpin structures in water through the formation of both αSQ- and βSQ-turns.
authors.forename: Luís
authors.initials: L
authors.lastname: Martínez
authors.forename: Gabriel
authors.initials: G
authors.lastname: Martorell
authors.forename: Ángel
authors.initials: Á
authors.lastname: Sampedro
authors.affiliation: §Institut of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007 Tarragona, Spain.|∥Catalan Institution of Research and Advanced Studies (ICREA), Passeig Lluís Compays 23, 08010 Barcelona, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Ballester
authors.forename: Antoni
authors.initials: A
authors.lastname: Costa
authors.forename: Carmen
authors.initials: C
authors.lastname: Rotger
mesh_terms: D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D000577:Amides; D010455:Peptides