title: Age dependency of ischaemic stroke subtypes and vascular risk factors in western Norway: the Bergen Norwegian Stroke Cooperation Study.
abstract: OBJECTIVE
  Age dependency of acute ischaemic stroke aetiology and vascular risk factors have not been adequately evaluated in stroke patients in Norway. Aims of this study were to evaluate how stroke subtypes and vascular risk factors vary with age in a western Norway stroke population.
  
  
  METHODS
  Patients aged 15-100 years consecutively admitted to our neurovascular centre with acute ischaemic stroke between 2006 and 2012 were included. The study population was categorized as young (15-49 years), middle-aged (50-74 years) or elderly (≥ 75 years). Stroke aetiology was defined by TOAST criteria. Risk factors and history of cardiovascular disease were recorded.
  
  
  RESULTS
  In total, 2484 patients with acute cerebral infarction were included: 1418 were males (57.3%). Mean age was 70.8 years (SD ± 14.9), 228 patients were young, 1126 middle-aged, and 1130 were elderly. The proportion of large-artery atherosclerosis and of small-vessel occlusion was highest among middle-aged patients. The proportion of cardioembolism was high at all ages, especially among the elderly. The proportion of stroke of other determined cause was highest among young patients. Some risk factors (diabetes mellitus, active smoking, angina pectoris, prior stroke and peripheral artery disease) decreased among the elderly. The proportions of several potential causes increased with age.
  
  
  CONCLUSIONS
  The proportion of stroke subtypes and vascular risk factors are age dependent. Age 50-74 years constitutes the period in life where cardiovascular risk factors become manifest and stroke subtypes change.
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Nacu
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Fromm
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: K M
authors.initials: KM
authors.lastname: Sand
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: U
authors.initials: U
authors.lastname: Waje-Andreassen
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: L
authors.initials: L
authors.lastname: Thomassen
authors.affiliation: Centre for Neurovascular Diseases, Department of Neurology, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Medicine, University of Bergen, Bergen, Norway.|Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Naess
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000150:complications / Q000453:epidemiology; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology*; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology; D059345:Cerebral Small Vessel Diseases / Q000150:complications / Q000453:epidemiology; D004617:Embolism / Q000453:epidemiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors; D012959:Socioeconomic Factors; D020521:Stroke / Q000453:epidemiology*; D055815:Young Adult
keywords: age; cardiovascular disease; ischaemic stroke; stroke aetiology; stroke subtypes; trial of org 10172 in acute stroke treatment; vascular risk factors