title: In vitro host range of feline morbillivirus.
abstract: Feline morbillivirus (FmoPV) is an emerging virus in cats, which is associated with tubulointerstitial nephritis. To study the in vitro host range of FmoPV, we inoculated FmoPV strain SS1 to 32 cell lines originated from 13 species and cultured for 2 weeks, followed by RNA extraction and reverse-transcription-polymerase chain reaction for FmoPV detection. As a result, only cell lines derived from cats and African green monkeys were susceptible to FmoPV. FmoPV infects diverse feline cell lines: epithelial, fibroblastic, lymphoid and glial cells. These results indicate that the receptor (s) for FmoPV are ubiquitously expressed in cats. No infectivity of FmoPV was observed in human cell lines, which suggests least threatening of cross-species transmission of FmoPV from cats to humans.
authors.affiliation: Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaharacho, Sakyu-ku, Kyoto 606-8507, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Rie
authors.initials: R
authors.lastname: Koide
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyazawa
mesh_terms: D000818:Animals; D002415:Cats; D002460:Cell Line; D021821:Communicable Diseases, Emerging; D058507:Host Specificity; D006801:Humans; D008322:Mammals; D018103:Morbillivirus / Q000145:classification / Q000502:physiology*