title: Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base.
abstract: Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2',4'-dihydroxyacetophenone and 1-phenylbutane-1,3-dione have been synthesized and characterized by elemental analysis, FTIR, UV-Visible spectroscopy, and screened to establish their potential as antibacterial agents, antioxidants and DPPH radical scavengers. The FTIR spectra showed that the ligand behaves as a dibasic tetradentate ligand with the dioxygen-dinitrogen donor atom system oriented towards the central metal ion. The analytical and spectroscopic data suggest a square planar geometry for Cu(II) and Ni(II) complexes and an octahedral geometry for the Co(II) complex. The ligand and their metal complexes were screened for antibacterial activity against Gram (+) and Gram (-) bacteria by the agar well diffusion method. In addition, the antioxidant activities of the complexes were also investigated through their scavenging effect on DPPH and ABTS radicals. The obtained IC50 value of the DPPH activity for the copper complex (2.08 ± 0.47 µM) and that of the ABTS activity for the copper complex (IC50 = 2.11 + 1.69 µM) were higher than the values obtained for the other compounds.
authors.affiliation: Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, P.B. X1314, Alice 5700, South Africa.
authors.forename: Ikechukwu P
authors.initials: IP
authors.lastname: Ejidike
authors.affiliation: Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, P.B. X1314, Alice 5700, South Africa. pajibade@ufh.ac.za.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Ajibade
mesh_terms: D000098:Acetophenones / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D052160:Benzothiazoles / Q000037:antagonists & inhibitors; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D002074:Butanones / Q000737:chemistry; D002413:Cations, Divalent; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry*; D010851:Picrates / Q000037:antagonists & inhibitors; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013451:Sulfonic Acids / Q000037:antagonists & inhibitors
chemical_list: D000098:Acetophenones; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D002074:Butanones; D002413:Cations, Divalent; D056831:Coordination Complexes; D005029:Ethylenediamines; D010851:Picrates; D012545:Schiff Bases; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C031234:ethylenediamine; D003300:Copper; D009532:Nickel; C078634:2,4-dihydroxyacetophenone; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: 2′,4′-dihydroxyacetophenone; ABTS; DPPH; antibacterial activity; unsymmetrical tetradentate Schiff base