title: Quality of Life and Late Complications After Minimally Invasive Compared to Open Esophagectomy: Results of a Randomized Trial.
abstract: BACKGROUND
  The minimally invasive esophagectomy (MIE) is widely being implemented for esophageal cancer in order to reduce morbidity and improve quality of life. Non-randomized studies investigating the mid-term quality of life after MIE show conflicting results at 1-year follow-up. Therefore, the aim of this study is to determine whether MIE has a continuing better mid-term 1-year quality of life than open esophagectomy (OE) indicating both a faster recovery and less procedure-related symptoms.
  
  
  METHODS
  A one-year follow-up analysis of the quality of life was conducted for patients participating in the randomized trial in which MIE was compared with OE. Late complications as symptomatic stenosis of anastomosis are also reported.
  
  
  RESULTS
  Quality of life at 1 year was better in the MIE group than in the OE group for the physical component summary SF36 [50 (6; 48-53) versus 45 (9; 42-48) p .003]; global health C30 [79 (10; 76-83) versus 67 (21; 60-75) p .004]; and pain OES18 module [6 (9; 2-8) versus 16 (16; 10-22) p .001], respectively. Twenty six patients (44%) in the MIE and 22 patients (39%) in the OE group were diagnosed and treated for symptomatic stenosis of the anastomosis.
  
  
  CONCLUSIONS
  This first randomized trial shows that MIE is associated with a better mid-term one-year quality of life compared to OE.
authors.affiliation: Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: K W
authors.initials: KW
authors.lastname: Maas
authors.forename: M A
authors.initials: MA
authors.lastname: Cuesta
authors.forename: M I
authors.initials: MI
authors.lastname: van Berge Henegouwen
authors.forename: J
authors.initials: J
authors.lastname: Roig
authors.forename: L
authors.initials: L
authors.lastname: Bonavina
authors.forename: C
authors.initials: C
authors.lastname: Rosman
authors.forename: S S
authors.initials: SS
authors.lastname: Gisbertz
authors.forename: S S A Y
authors.initials: SS
authors.lastname: Biere
authors.forename: D L
authors.initials: DL
authors.lastname: van der Peet
authors.forename: J H
authors.initials: JH
authors.lastname: Klinkenbijl
authors.forename: M W
authors.initials: MW
authors.lastname: Hollmann
authors.forename: E S
authors.initials: ES
authors.lastname: de Lange
authors.forename: H J
authors.initials: HJ
authors.lastname: Bonjer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000473:pathology / Q000534:rehabilitation / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects / Q000379:methods / Q000534:rehabilitation; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009367:Neoplasm Staging; D011594:Psychometrics; D011788:Quality of Life; D055815:Young Adult