title: Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis.
abstract: Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.
authors.affiliation: Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Althanstrasse 14 (UZA II), 1090 Vienna (Austria).
authors.forename: Nicole
authors.initials: N
authors.lastname: Kretschy
authors.affiliation: Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna (Austria).
authors.forename: Ann-Katrin
authors.initials: AK
authors.lastname: Holik
authors.affiliation: Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna (Austria).|Christian Doppler Laboratory for Bioactive Aroma Compounds, University of Vienna (Austria).
authors.forename: Veronika
authors.initials: V
authors.lastname: Somoza
authors.affiliation: Roche Diagnostics, Penzberg (Germany).
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Stengele
authors.affiliation: Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Althanstrasse 14 (UZA II), 1090 Vienna (Austria). mark.somoza@univie.ac.at.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Somoza
mesh_terms: D008027:Light; D046228:Microarray Analysis; D009578:Nitrobenzenes / Q000737:chemistry*; D010782:Photolysis
chemical_list: D009578:Nitrobenzenes
keywords: microarrays; photochemistry; photolysis; protecting groups