title: Regulation of transcription elongation and termination.
abstract: This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect elongation and termination. The connection between translation and transcription elongation is described. Finally we present an overview indicating where progress has been made and where it has not.
authors.affiliation: Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. rw378@cumc.columbia.edu.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Washburn
authors.affiliation: Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. meg8@columbia.edu.|Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA. meg8@columbia.edu.
authors.forename: Max E
authors.initials: ME
authors.lastname: Gottesman
mesh_terms: D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D061805:Transcription Elongation, Genetic; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D061806:Transcription Termination, Genetic
chemical_list: D029968:Escherichia coli Proteins; D014157:Transcription Factors
keywords: Nus factors; transcription antitermination; transcription elongation; transcription pausing; transcription termination; transcription-translation coupling