title: Serological evidence of human infection with Pteropine orthoreovirus in Central Vietnam.
abstract: Pteropine orthoreovirus, potentially of bat origin, has been reported to cause respiratory tract infections among human beings in Southeast Asia. Twelve IgG ELISA-positive cases with antibodies against Pteropine orthoreovirus were detected among 272 human serum samples collected between March and June 2014 from in and around Hue City, Central Vietnam. These 12 cases were IgM ELISA negative. Neutralizing antibodies were also detected among six of these cases with the highest titer of 1:1,280 in 2 cases (both female, 32 and 68 years old, respectively). This is the first report of human infection with Pteropine orthoreovirus in Central Vietnam. These findings indicate the need for surveillance on Pteropine orthoreovirus infections in Southeast Asia to enable prevention and control strategies to be developed should a change in virulence occur.
authors.affiliation: Department of Intelligent Mechanical Systems, Graduate School of System Design, Tokyo Metropolitan University, Tokyo, Japan.|Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Harpal
authors.initials: H
authors.lastname: Singh
authors.affiliation: Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimojima
authors.affiliation: Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue City, Vietnam.
authors.forename: Thanh Cao
authors.initials: TC
authors.lastname: Ngoc
authors.affiliation: Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue City, Vietnam.
authors.forename: Nguyen Vu
authors.initials: NV
authors.lastname: Quoc Huy
authors.affiliation: Department of Infectious Diseases, Hue University of Medicine and Pharmacy, Hue City, Vietnam.
authors.forename: Tran Xuan
authors.initials: TX
authors.lastname: Chuong
authors.affiliation: Department of Microbiology, Hue University of Medicine and Pharmacy, Hue City, Vietnam.
authors.forename: An
authors.initials: A
authors.lastname: Le Van
authors.affiliation: Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijo
authors.affiliation: Department of Intelligent Mechanical Systems, Graduate School of System Design, Tokyo Metropolitan University, Tokyo, Japan.
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Infectious Diseases, Hue University of Medicine and Pharmacy, Hue City, Vietnam.|Department of Microbiology, Hue University of Medicine and Pharmacy, Hue City, Vietnam.|Department of Hygiene and Public Health, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Sugamata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D018165:Orthoreovirus / Q000276:immunology*; D012088:Reoviridae Infections / Q000175:diagnosis* / Q000453:epidemiology; D012698:Serologic Tests; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: Central Vietnam; ELISA; Hue City; indirect immunofluorescence assay; neutralization test; seroepidemiology