title: Mitochondrial intergenic COII/tRNA(Lys) 9-bp deletion, a biomarker for hepatocellular carcinoma?
abstract: The COII/tRNA(Lys) intergenic 9-bp deletion is one of the most commonly studied human mitochondrial DNA (mtDNA) polymorphisms. It consists of the loss of one of two tandemly repeated copies of the sequence CCCCCTCTA from a non-coding region located between cytochrome oxidase II (COII) and tRNA(Lys) gene. Most recently, case-control studies have shown a positive association between this deletion with hepatocellular cancer. In this study, we first performed a detailed analysis between this deletion and clinical diseases; moreover, we took the phylogenetic approach to examine the pathogenicity status of 9-bp deletion.
authors.affiliation: a Central Laboratory .
authors.forename: Weihua
authors.initials: W
authors.lastname: Ren
authors.affiliation: b Department of Orthopedics .
authors.forename: Yawei
authors.initials: Y
authors.lastname: Li
authors.affiliation: c Department of Neurosurgery .
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: d Department of Otorhinolaryngology , and.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Feng
authors.affiliation: e Department of Anesthesiology , Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , He'nan , China.
authors.forename: Shuangting
authors.initials: S
authors.lastname: Wu
authors.affiliation: a Central Laboratory .
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Mao
authors.affiliation: a Central Laboratory .
authors.forename: Lei
authors.initials: L
authors.lastname: Huang
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics*; D054629:Genome, Mitochondrial / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009690:Nucleic Acid Conformation; D010802:Phylogeny; D012357:RNA, Transfer, Lys / Q000235:genetics*; D017384:Sequence Deletion / Q000235:genetics* / Q000502:physiology
chemical_list: D004272:DNA, Mitochondrial; D012357:RNA, Transfer, Lys; C117108:cytochrome C oxidase subunit II; D003576:Electron Transport Complex IV
keywords: COII/tRNALys intergenic 9-bp deletion; mitochondrial DNA; pathogenicity; phylogenetic analysis