title: Interleukin polymorphisms in aggressive periodontitis: A literature review.
abstract: Aggressive periodontitis (AgP), occurs in a younger age group (≤35 years) and is associated with the rapid destruction of periodontal attachment and supporting bone. Genetic polymorphisms are allelic variants that occur in at least 1% of the population that could potentially alter the function of the proteins that they encode. Interleukins are a group of cytokines that have complex immunological functions including proliferation, migration, growth and differentiation of cells and play a key role in the immunopathogenesis of periodontal disease. The aim of this review was to summarize the findings of studies that reported associations or potential associations of polymorphisms in the interleukin family of cytokines, specifically with AgP.
authors.affiliation: Department of Periodontics, Louisiana State University Health Sciences Center, School of Dentistry, New Orleans, Louisiana, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Maney
authors.affiliation: Department of Periodontics, Louisiana State University Health Sciences Center, School of Dentistry, New Orleans, Louisiana, USA.
authors.forename: Jessica Leigh
authors.initials: JL
authors.lastname: Owens
keywords: Aggressive periodontitis; interleukin; polymorphisms