title: Liver depurative techniques: a single liver transplantation center experience.
abstract: BACKGROUND
  In a liver transplant (LT) center, treatments with Prometheus were evaluated. The main outcome considered was 1 and 6 months survival.
  
  
  METHODS
  During the study period, 74 patients underwent treatment with Prometheus; 64 were enrolled, with a mean age of 51 ± 13 years; 47 men underwent 212 treatments (mean, 3.02 per patient). The parameters evaluated were age, sex, laboratorial (liver enzymes, ammonia) and clinical (model for end-stage liver disease and Child-Turcotte-Pugh score) data.
  
  
  RESULTS
  Death was verified in 23 patients (35.9%) during the hospitalization period, 20 patients (31.3%) were submitted to liver transplantation, and 21 were discharged. LT was performed in 4 patients with acute liver failure (ALF, 23.7%), in 7 patients with acute on chronic liver failure (AoCLF, 43.7%), and in 6 patients with liver disease after LT (30%). Seven patients who underwent LT died (35%). In the multivariate analysis, older age (P = .015), higher international normalized ratio (INR) (P = .019), and acute liver failure (P = .039) were independently associated with an adverse 1-month clinical outcome. On the other hand, older age (P = .011) and acute kidney injury (P = .031) at presentation were both related to worse 6-month outcome. For patients with ALF and AoCLF we did not observe the same differences.
  
  
  CONCLUSIONS
  In this cohort, older age was the most important parameter defining 1- and 6-month survival, although higher INR and presence of ALF were important for 1-month survival and AKI for 6-month survival. No difference was observed between patients who underwent LT or did not have LT.
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Rodrigues
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: S G
authors.initials: SG
authors.lastname: Castro
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Moya
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Fortuna
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martins
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisbon, Portugal.
authors.forename: J P
authors.initials: JP
authors.lastname: Pereira
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Bento
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisbon, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Perdigoto
authors.affiliation: Hospital Curry Cabral, Liver Transplantation Unit, Lisbon, Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Barroso
authors.affiliation: Hospital Curry Cabral, Intensive Care Unit, Lisbon, Spain. Electronic address: jp.azevedo.rodrigues@gmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Marcelino
mesh_terms: D058625:End Stage Liver Disease / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017114:Liver Failure, Acute / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011174:Portugal / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors