title: [Radiotherapy for local recurrences of prostate cancer after radical prostatectomy].
abstract: Basic and universally accepted method of treatment of local recurrence is local radiotherapy. The most researchers tend to favor of the early start of radiotherapy: PSA no more than 0.5-1.0 ng/ml, until manifestation of signs clinical recurrence of disease as well as in terms of PSA doubling for at least 6 months. Morphological verification of recurrence is not a necessary condition for the administration of radiotherapy. In cases of impossibility of verification or its negative result, it should focus primarily on the dynamics of PSA and data of instrumental examination. Standard methods remote radiotherapy (3D-conformal radiotherapy, intensity modulated radiation therapy--IMRT) can be successfully used in these patients at ODS 66-70 Gy, with the escalation of SOD 70 g more justified in a limited category of patients. Joining of hormone therapy in neoadjuvant and parallel with radiotherapy modes did not show significant improvement in disease-free survival rates however in certain categories of patients had advantages.
authors.forename: Yu A
authors.initials: YA
authors.lastname: Grishina
authors.forename: E V
authors.initials: EV
authors.lastname: Khmelevsky
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D018572:Disease-Free Survival; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000532:radiotherapy*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery*; D020266:Radiotherapy, Conformal / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen