title: Prospective cohort study with active surveillance for fever in four dengue endemic countries in Latin America.
abstract: To prepare for a Phase III dengue vaccine efficacy trial, 20 investigational sites were selected for this observational study to identify dengue infections in a closed cohort (N = 3,000 children 9-16 years of age). Of 255 acute febrile episodes experienced by 235 children, 50 (21.3%) were considered serologically probable dengue, and 18 (7.7%) were considered virologically confirmed (i.e., dengue NS1 antigen positive) dengue cases. Considering the disease-free and at-risk period from study start to onset of symptoms, the overall incidence density of acute febrile episodes was 17.7 per 100 person-years of follow-up, ranging from 15.3 in Colombia to 22.0 in Puerto Rico. This study showed that all sites were capable of capturing and following up acute febrile episodes within a specific timeframe among the established cohort and to detect dengue cases.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Dayan
authors.forename: Jose L
authors.initials: JL
authors.lastname: Arredondo
authors.forename: Gabriel
authors.initials: G
authors.lastname: Carrasquilla
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Deseda
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Dietze
authors.forename: Kleber
authors.initials: K
authors.lastname: Luz
authors.forename: Maria Selma N
authors.initials: MSN
authors.lastname: Costa
authors.forename: Rivaldo V
authors.initials: RV
authors.lastname: Cunha
authors.forename: Luis C
authors.initials: LC
authors.lastname: Rey
authors.forename: Javier
authors.initials: J
authors.lastname: Morales
authors.forename: Humberto
authors.initials: H
authors.lastname: Reynales
authors.forename: Maria
authors.initials: M
authors.lastname: Miranda
authors.forename: Betzana
authors.initials: B
authors.lastname: Zambrano
authors.forename: Enrique
authors.initials: E
authors.lastname: Rivas
authors.forename: Pedro
authors.initials: P
authors.lastname: Garbes
authors.forename: Fernando
authors.initials: F
authors.lastname: Noriega
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000097:blood*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D003105:Colombia / Q000453:epidemiology; D003715:Dengue / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology*; D019353:Endemic Diseases; D062665:Epidemiological Monitoring; D005260:Female; D005334:Fever / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D015994:Incidence; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011446:Prospective Studies; D011647:Puerto Rico / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral