title: Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.
abstract: Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, United States.
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D004880:Ergothioneine / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces / Q000737:chemistry
chemical_list: D001688:Biological Products; D011763:Pyrrolizidine Alkaloids; C000602701:spithioneine A; C000602702:spithioneine B; C025548:bohemamine; D004880:Ergothioneine