title: Effect of androgen deprivation on the expression of aquaporins in rat prostate and seminal vesicles.
abstract: The aim of this study was to investigate the level of secretions of prostate and seminal vesicles and its association with the expression of AQP0, 1, 4, 5, 6 and 8 in castrated rats. Eight-week-old male Sprague-Dawley (SD) rats (n = 18) were randomly divided into control group, castrated rats group and castrated followed testosterone replacement group. Four weeks after surgery, the secretions and expression of AQP0, 1, 4, 5, 6 and 8 of prostate and seminal vesicles were determined. Serum testosterone was significantly lower in castrated groups than in control and testosterone replacement groups (P < 0.05). The level of prostate and seminal vesicle secretions and the expressions of AQP0, 1, 4, 5, 6 and 8 in prostate and seminal vesicles were significantly lower in castrated group than in control and castrated followed testosterone replacement groups (P < 0.05). The decreased prostatic and seminal vesicle secretions in castrated rats may be related to the decrease in AQP0, 1, 4, 5, 6 and 8 in prostatic tissue and seminal vesicles.
authors.affiliation: Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
authors.forename: J C
authors.initials: JC
authors.lastname: Tian
authors.affiliation: Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Xia
authors.affiliation: Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
authors.forename: R
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: He
authors.affiliation: Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: H
authors.initials: H
authors.lastname: Lin
mesh_terms: D000818:Animals; D020346:Aquaporins / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012669:Seminal Vesicles / Q000378:metabolism*; D013739:Testosterone / Q000097:blood* / Q000494:pharmacology
chemical_list: D020346:Aquaporins; D013739:Testosterone
keywords: Androgen; aquaporins; prostate; rat; seminal vesicles