title: Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide.
abstract: A straightforward and convenient approach for trifluoromethylthiolation of various acyclic and cyclic ketones with PhNHSCF3 is described. The reaction proceeds smoothly in the presence of acetyl chloride at room temperature and affords α-trifluoromethylthiolated ketones in fair to good yields.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai 200237, China. scao@ecust.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xuxue
authors.initials: X
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Liang
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D054879:Halogenation; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D008745:Methylation; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006844:Hydrocarbons, Cyclic; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D013438:Sulfhydryl Compounds