title: Recent advances in click chemistry applied to dendrimer synthesis.
abstract: Dendrimers are monodisperse polymers grown in a fractal manner from a central point. They are poised to become the cornerstone of nanoscale devices in several fields, ranging from biomedicine to light-harvesting. Technical difficulties in obtaining these molecules has slowed their transfer from academia to industry. In 2001, the arrival of the "click chemistry" concept gave the field a major boost. The flagship reaction, a modified Hüisgen cycloaddition, allowed researchers greater freedom in designing and building dendrimers. In the last five years, advances in click chemistry saw a wider use of other click reactions and a notable increase in the complexity of the reported structures. This review covers key developments in the click chemistry field applied to dendrimer synthesis from 2010 to 2015. Even though this is an expert review, basic notions and references have been included to help newcomers to the field.
authors.affiliation: Chimie, Université Laval, 1045 avenue de la Médecine, Pavillon Alexandre-Vachon, QC G1V 0A6, Canada. mathieu.arseneault.1@ulaval.ca.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Arseneault
authors.affiliation: Chimie, Université Laval, 1045 avenue de la Médecine, Pavillon Alexandre-Vachon, QC G1V 0A6, Canada. caroline.wafer.1@ulaval.ca.
authors.forename: Caroline
authors.initials: C
authors.lastname: Wafer
authors.affiliation: Chimie, Université Laval, 1045 avenue de la Médecine, Pavillon Alexandre-Vachon, QC G1V 0A6, Canada. jean-francois.morin@chm.ulaval.ca.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Morin
mesh_terms: D057930:Click Chemistry / Q000379:methods*; D061565:Cycloaddition Reaction / Q000379:methods*; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D050091:Dendrimers
keywords: Diels-Alder; Hüisgen cycloaddition; click; dendrimer; dendron; thiol-ene; thiol-yne