title: The neuroplastic effect of working memory training in healthy volunteers and patients with schizophrenia: Implications for cognitive rehabilitation.
abstract: We conducted an activation likelihood estimation (ALE) meta-analysis to quantitatively review the existing working memory (WM) training studies that investigated neural activation changes both in healthy individuals and patients with schizophrenia. ALE analysis of studies in healthy individuals indicates a widespread distribution of activation changes with WM training in the frontal and parietal regions, especially the dorsolateral prefrontal cortex, the medial frontal cortex and the precuneus, as well as subcortical regions such as the insula and the striatum. WM training is also accompanied by activation changes in patients with schizophrenia, mainly in the dorsolateral prefrontal cortex, the precuneus and the fusiform gyrus. Our results demonstrate that WM training is accompanied by changes in neural activation patterns in healthy individuals, which may provide the basis for understanding neuroplastic changes in patients with schizophrenia.
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; The University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Li
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; The University of Chinese Academy of Sciences, Beijing, China.
authors.forename: Ya-hui
authors.initials: YH
authors.lastname: Xiao
authors.affiliation: School of Applied Psychology and Behavioural Basis of Health Program, Griffith Health Institute, Griffith University, Brisbane, Australia.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Occupational Therapy & Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada; Rotman Research Institute at Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada.
authors.forename: Ada W W
authors.initials: AW
authors.lastname: Leung
authors.affiliation: Castle Peak Hospital, Hong Kong Special Administrative Region.
authors.forename: Eric F C
authors.initials: EF
authors.lastname: Cheung
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. Electronic address: rckchan@psych.ac.cn.
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D064368:Healthy Volunteers; D006801:Humans; D007858:Learning / Q000502:physiology*; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009473:Neuronal Plasticity; D010296:Parietal Lobe / Q000503:physiopathology; D012559:Schizophrenia / Q000503:physiopathology* / Q000534:rehabilitation*; D012565:Schizophrenic Psychology
keywords: Activation likelihood estimation meta-analysis; Imaging; Schizophrenia; Training; Working memory