title: The value of the high-sensitivity modified Glasgow prognostic score in predicting the survival of patients with a soft-tissue sarcoma.
abstract: The aim of this study was to determine whether the high-sensitivity modified Glasgow prognostic score (Hs-mGPS) could predict the disease-specific survival and oncological outcome in adult patients with non-metastatic soft-tissue sarcoma before treatment. A total of 139 patients treated between 2001 and 2012 were retrospectively reviewed. The Hs-mGPS varied between 0 and 2. Patients with a score of 2 had a poorer disease-specific survival than patients with a score of 0 (p < 0.001). The estimated five-year rate of disease-specific survival for those with a score of 2 was 0%, compared with 85.4% (95% CI 77.3 to 93.5) for those with a score of 0. Those with a score of 2 also had a poorer disease-specific survival than those with a score of 1 (75.3%, 95% CI 55.8 to 94.8; p < 0.001). Patients with a score of 2 also had a poorer event-free rate than those with a score of 0 (p < 0.001). Those with a score of 2 also had a poorer event-free survival than did those with a score of 1 (p = 0.03). A multivariate analysis showed that the Hs-mGPS remained an independent predictor of survival and recurrence. The Hs-mGPS could be a useful prognostic marker in patients with a soft-tissue sarcoma.
authors.affiliation: Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsumine
authors.affiliation: Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asanuma
authors.affiliation: Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsubara
authors.affiliation: Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-city, Mie, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D003131:Combined Modality Therapy; D051677:Histiocytoma, Malignant Fibrous / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D006801:Humans; D008080:Liposarcoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000378:metabolism / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D002097:C-Reactive Protein
keywords: Albumin; C-reactive protein; Glasgow prognostic score; Soft-tissue sarcoma