title: Pd-Catalyzed Regioselective Activation of gem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds.
abstract: An unprecedented Pd-catalyzed regioselective activation of gem-difluorinated cyclopropanes induced by C-C bond cleavage is reported. It provides a general and efficient access to a variety of 2-fluoroallylic amines, ethers, esters, and alkylation products in high Z-selectivity, which are important skeletons in many biologically active molecules. In addition, the transformation represents the first general application of gem-difluorinated cyclopropanes as reaction partners in transition-metal-catalyzed cross-coupling reaction.
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).|School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China).
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).
authors.forename: Ebrahim-Alkhalil
authors.initials: EA
authors.lastname: Ahmed
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Lu
authors.affiliation: School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China).
authors.forename: Yun-Long
authors.initials: YL
authors.lastname: Wang
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China).
authors.forename: Chu-Guo
authors.initials: CG
authors.lastname: Yu
authors.affiliation: iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China). fuyao@ustc.edu.cn.
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
mesh_terms: D000478:Alkylation / Q000502:physiology*; D002384:Catalysis; D003521:Cyclopropanes / Q000737:chemistry*; D054879:Halogenation / Q000502:physiology*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D010165:Palladium
keywords: C(sp3)F activation; CC bond cleavage; fluorinated compounds; gem-difluorinated cyclopropanes; palladium