title: A retrospective analysis of 25% human serum albumin supplementation in hypoalbuminemic dogs with septic peritonitis.
abstract: This study describes the influence of 25% human serum albumin (HSA) supplementation on serum albumin level, total protein (TP), colloid osmotic pressure (COP), hospital stay, and survival in dogs with septic peritonitis. Records of 39 dogs with septic peritonitis were evaluated. In the HSA group, initial and post-transfusion TP, albumin, COP, and HSA dose were recorded. In the non-supplemented group, repeated values of TP, albumin, and COP were recorded over their hospitalization. Eighteen dogs survived (53.8% mortality). Repeat albumin values were higher in survivors (mean 23.9 g/L) and elevated repeat albumin values were associated with HSA supplementation. Repeat albumin and TP were higher in the HSA supplemented group (mean 24 g/L and 51.9 g/L, respectively) and their COP increased by 5.8 mmHg. Length of hospitalization was not affected. Twenty-five percent HSA increases albumin, TP, and COP in canine patients with septic peritonitis. Higher postoperative albumin levels are associated with survival.
authors.affiliation: 130 Hempstead Avenue #400, West Hempstead, New York 11552, USA (Horowitz); College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Powell); Aspen Meadow Veterinary Specialists, 104 South Main Street, Longmont, Colorado 80501, USA (Read).
authors.forename: Farrah B
authors.initials: FB
authors.lastname: Horowitz
authors.affiliation: 130 Hempstead Avenue #400, West Hempstead, New York 11552, USA (Horowitz); College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Powell); Aspen Meadow Veterinary Specialists, 104 South Main Street, Longmont, Colorado 80501, USA (Read).
authors.forename: Robyn L
authors.initials: RL
authors.lastname: Read
authors.affiliation: 130 Hempstead Avenue #400, West Hempstead, New York 11552, USA (Horowitz); College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, Saint Paul, Minnesota 55108, USA (Powell); Aspen Meadow Veterinary Specialists, 104 South Main Street, Longmont, Colorado 80501, USA (Read).
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Powell
mesh_terms: D000818:Animals; D001803:Blood Transfusion / Q000662:veterinary; D003102:Colloids; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D006801:Humans; D034141:Hypoalbuminemia / Q000188:drug therapy / Q000662:veterinary*; D010538:Peritonitis / Q000150:complications / Q000662:veterinary*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000627:therapeutic use*
chemical_list: D003102:Colloids; D012709:Serum Albumin