title: Role of the satiety factor oleoylethanolamide in alcoholism.
abstract: Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-α). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR-α agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.|Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty of Mannheim, University of Heidelberg, Germany.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Bilbao
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.|Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Antonia
authors.initials: A
authors.lastname: Serrano
authors.affiliation: School of Pharmacy, Pharmacology Unit, University of Camerino, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cippitelli
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.|Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Pavón
authors.affiliation: Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Giuffrida
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Suárez
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.|Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: García-Marchena
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Baixeras
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Gómez de Heras
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Orio
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Alén
authors.affiliation: School of Pharmacy, Pharmacology Unit, University of Camerino, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Ciccocioppo
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Benjamin F
authors.initials: BF
authors.lastname: Cravatt
authors.affiliation: Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA.
authors.forename: Loren H
authors.initials: LH
authors.lastname: Parsons
authors.affiliation: Departments of Anatomy and Neurobiology, Pharmacology, and Biological Chemistry, University of California, Irvine, CA, USA.|Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Piomelli
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Instituto IBIMA-Hospital Regional Universitario de Málaga, Spain.|Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Rodríguez de Fonseca
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism* / Q000523:psychology*; D000437:Alcoholism / Q000378:metabolism* / Q000523:psychology*; D000818:Animals; D004195:Disease Models, Animal; D063388:Endocannabinoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009829:Oleic Acids / Q000494:pharmacology*; D047493:PPAR alpha / Q000187:drug effects / Q000378:metabolism; D017208:Rats, Wistar; D012528:Satiety Response / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D063388:Endocannabinoids; D009829:Oleic Acids; D047493:PPAR alpha; C488250:oleoylethanolamide
keywords: Alcohol self-administration; PPAR-α; alcoholism; oleoylethanolamide; relapse