title: Sclerotiorin is non-mutagenic and inhibits human PMNL 5-lipoxygenase and platelet aggregation.
abstract: Sclerotiorin, isolated from the fermented broth of Penicillium frequentans, exhibited potent inhibition against human polymorphonuclear leukocytes 5-lipoxygenase and human platelet aggregation with a half maximal value 36 μM and 250 μM, respectively. Further, the Ames test has demonstrated the sclerotiorin to be non-mutagenic.
authors.forename: C
authors.initials: C
authors.lastname: Chidananda
authors.forename: K Y
authors.initials: KY
authors.lastname: Vasantha
authors.forename: A P
authors.initials: AP
authors.lastname: Sattur
mesh_terms: D001094:Arachidonate 5-Lipoxygenase / Q000187:drug effects*; D001578:Benzopyrans / Q000494:pharmacology*; D005285:Fermentation; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009504:Neutrophils / Q000201:enzymology*; D010407:Penicillium / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics
chemical_list: D001578:Benzopyrans; D016859:Lipoxygenase Inhibitors; D010975:Platelet Aggregation Inhibitors; C101449:sclerotiorin; D001094:Arachidonate 5-Lipoxygenase