title: Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas.
abstract: Manganese (Mn)-based nanoparticles have been proved to be promising MR T1 contrast agents for the diagnosis of brain tumors. However, most of them exhibit a low relaxation rate, resulting in an insufficient enhancement effect on tiny gliomas. Herein, we developed gadolinium (Gd)-doped MnCO3 nanoparticles with a size of 11 nm via the thermal decomposition of Mn-oleate in the presence of Gd-oleate. Owing to the small size and Gd doping, these Gd-doped MnCO3 NPs, when endowed with excellent aqueous dispersibility and colloidal stability, exhibited a high r1 relaxivity of 6.81 mM(-1) s(-1). Moreover, the Gd/MnCO3 NPs were used as a reliable platform to construct a glioma-targeted MR/fluorescence bimodal nanoprobe. The high relaxivity, the bimodal imaging capability, and the specificity nominate the multifunctional Gd doped MnCO3 NPs as an effective nanoprobe for the diagnostic imaging of tiny brain gliomas with an improved efficacy.
authors.affiliation: †School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Shao
authors.affiliation: †School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.affiliation: †School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: §School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Ningqiang
authors.initials: N
authors.lastname: Gong
authors.affiliation: †School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: ∥Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.affiliation: ‡College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 210620, P. R. China.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
authors.affiliation: †School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002254:Carbonates / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005453:Fluorescence; D005682:Gadolinium / Q000737:chemistry*; D005910:Glioma / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography; D014407:Tumor Cells, Cultured
chemical_list: D002254:Carbonates; D003287:Contrast Media; D008345:Manganese; C045327:manganese carbonate; D005682:Gadolinium