title: Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease.
abstract: OBJECTIVE
  To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally balance the sensitivity and specificity.
  
  
  METHODS
  We focused on 206 non-demented subjects from memory clinic. We then classified each individual as having MCI or subjective cognitive decline (SCD) according to different neuropsychological criteria. By following them longitudinally, clinical outcomes were compared to evaluate the stability of MCI diagnoses and prediction of progression.
  
  
  RESULTS
  The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, resulted in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient Alzheimer's disease (AD) patients in SCD group who eventually converted to dementia. The delayed recall of complex figure test (CFT_DR) identified fewer MCI patients (n=95) and misdiagnosed more preclinical AD patients (15.3%), in comparison with AVLT criterion. Criterion requiring deficits in both tests produced higher conversion rate (54.3%), but resulted in higher misdiagnosis rate (14.7%) simultaneously. The AVLT criterion had the largest area under the curve (0.7248, p<0.05).
  
  
  CONCLUSIONS
  AVLT is superior to CFT in the stability of diagnoses and prediction of progression. In the clinical setting, the "one test" criterion AVLT has similar sensitivity to both-deficits methods, and is optimal in balancing sensitivity and specificity.
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: No. 12 Wulumuqi Rd(M), Shanghai, China, 200040. dr.guoqihao@126.com.
authors.forename: Qihao
authors.initials: Q
authors.lastname: Guo
authors.forename: Xiaoniu
authors.initials: X
authors.lastname: Liang
authors.forename: Meirong
authors.initials: M
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ding
authors.initials: D
authors.lastname: Ding
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
mesh_terms: D000161:Acoustic Stimulation; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014706:Verbal Learning / Q000502:physiology*