title: [Review of patients studied for coagulopathy in a Hematology/Oncology unit].
abstract: BACKGROUND
  Symptoms/signs suggestive of coagulopathy is a frequent complaint in Pediatric Hematology units. Both the clinical and family history are essential for diagnosis.
  
  
  METHODS
  Retrospective and descriptive study of patients referred to a Pediatric Hematology unit of a tertiary hospital for possible coagulopathy during 2012.
  
  
  RESULTS
  A total of 47 children were studied, of whom 61.7% had not previously suffered bleeding. The most frequent reason for referral was an eloganted activated partial thromboplastin time without any hemorrhage (42.5%), of these, 25% were diagnosed of a coagulopathy with a real risk of bleeding. While patients referred due to an eloganted activated partial thromboplastin time with bleeding more frequently (41.7%) have a coagulopathy with a real risk of bleeding. Children with a family history of bleeding are diagnosed more frequently with a coagulopathy with a real risk of bleeding: 37.5% (family history) vs. 14.3% (without). The most frequent diagnoses were: healthy children (48.9%), von Willebrand type 1 disease (19.1%), factor xii deficiency (19.1%), factor xi deficiency (4.2%), prekalikrein/high molecular weight kininogen deficiency (2.1%), acquired deficiency of factor x (2.1%), and factor ix deficiency (2.1%).
  
  
  CONCLUSIONS
  A thorough personal and family bleeding history and physical examination are the first steps for a correct differential diagnosis. The reason for referral should be based more on clinical bleeding and not just on an abnormal coagulation time. The most frequent diagnoses were type 1 von Willebrand disease and factor xii deficiency.
authors.affiliation: Unidad de Onco-Hematología Pediátrica, Hospital Universitario Virgen Macarena, Unidad de Gestión Clínica Intercentros de Oncología Pediátrica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, España.
authors.forename: I
authors.initials: I
authors.lastname: Romero
authors.affiliation: Unidad de Onco-Hematología Pediátrica, Hospital Universitario Virgen Macarena, Unidad de Gestión Clínica Intercentros de Oncología Pediátrica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, España. Electronic address: nuriaconde@hotmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Conde
authors.affiliation: Unidad de Onco-Hematología Pediátrica, Hospital Universitario Virgen Macarena, Unidad de Gestión Clínica Intercentros de Oncología Pediátrica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, España.
authors.forename: D
authors.initials: D
authors.lastname: García Aldana
authors.affiliation: Sección de Trombología, Hospital Universitario Virgen Macarena, Unidad de Gestión Clínica Intercentros de Hematología, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, España.
authors.forename: A
authors.initials: A
authors.lastname: Ruano
authors.affiliation: Unidad de Onco-Hematología Pediátrica, Hospital Universitario Virgen Macarena, Unidad de Gestión Clínica Intercentros de Oncología Pediátrica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Sevilla, España.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Teijeiro
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis*; D001780:Blood Coagulation Tests; D002648:Child; D003937:Diagnosis, Differential; D005175:Factor XII Deficiency / Q000175:diagnosis; D006405:Hematology; D006801:Humans; D010314:Partial Thromboplastin Time; D012189:Retrospective Studies; D014842:von Willebrand Diseases / Q000175:diagnosis
keywords: Coagulation tests; Coagulopathy; Coagulopatía; Enfermedad de von Willebrand; Pediatric bleeding; Pruebas de coagulación; Sangrado infantil; Von Willebrand disease