title: Control of Microbial Growth in Alginate/Polydopamine Core/Shell Microbeads.
abstract: Microbial microencapsulation not only protects microorganisms from harmful environments by physically isolating them from the outside media but also has the potential to tailor the release profile of the encapsulated cells. However, the microbial release has not yet been controlled tightly, leading to undesired detrimental exposure of microorganisms to the outside. In this work, we suggest a simple method for controlling the cell release by suppressing the microbial growth in the microbeads. Alginate microbeads, encapsulating yeast cells, were coated with ultrathin but robust polydopamine shells, and the resulting core/shell structures effectively reduced the growth rate, while maintaining the cell viability.
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 305-701, Korea.
authors.forename: Beom Jin
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 305-701, Korea.
authors.forename: Taegyun
authors.initials: T
authors.lastname: Park
authors.affiliation: Department of Chemistry, Sungkyunkwan University, Suwon, 440-746, Korea.
authors.forename: So-Young
authors.initials: SY
authors.lastname: Park
authors.affiliation: Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon, 305-701, Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Han
authors.affiliation: Molecular-Level Interface Research Center, Department of Chemistry, KAIST, Daejeon, 305-701, Korea.
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Sungkyunkwan University, Suwon, 440-746, Korea. ygkimmit@skku.edu.
authors.forename: Yang-Gyun
authors.initials: YG
authors.lastname: Kim
authors.affiliation: Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejeon, 305-701, Korea. ischoi@kaist.ac.kr.
authors.forename: Insung S
authors.initials: IS
authors.lastname: Choi
mesh_terms: D000464:Alginates / Q000737:chemistry*; D004339:Drug Compounding; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D015003:Yeasts / Q000502:physiology*
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D007211:Indoles; D011108:Polymers; C568283:polydopamine; D020723:Glucuronic Acid
keywords: encapsulation; gels; microbeads; nanostructures; polydopamine