title: The Remedial Efficacy of Spirulina platensis versus Chromium-Induced Nephrotoxicity in Male Sprague-Dawley Rats.
abstract: This study was conducted to investigate the possible protective effect of Spirulina platensis against chromium-induced nephrotoxicity. A total of 36 adult male Sprague-Dawley rats were divided into 4 equal groups (Gps). Gp1 served as control, rats of Gps 2, 3, and 4 were exposed to Spirulina platensis (300 mg/kg b.wt per os) and sodium dichromate dihydrate (SDD) via drinking water at concentration of 520 mg /l respectively. Chromium administration caused alterations in the renal function markers as evidenced by significant increase of blood urea and creatinine levels accompanied with significant increase in kidney's chromium residues and MDA level as well as decreased catalase activity and glutathion content in kidney tissue. Histologically, Cr provoked deleterious changes including: vascular congestion, wide spread tubular epithelium necrobiotic changes, atrophy of glomerular tuft and proliferative hyperplasia. The latter was accompanied with positive PCNA expression in kidney tissues as well as DNA ploidy interpretation of major cellular population of degenerated cells, appearance of tetraploid cells, high proliferation index and high DNA index. Morphometrical measurements revealed marked glomerular and tubular lumen alterations. On contrary, spirulina co-treatment with Cr significantly restored the histopathological changes, antioxidants and renal function markers and all the previously mentioned changes as well.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: M O
authors.initials: MO
authors.lastname: Elshazly
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: Sahar S
authors.initials: SS
authors.lastname: Abd El-Rahman
authors.affiliation: Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Morgan
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: Merhan E
authors.initials: ME
authors.lastname: Ali
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D002857:Chromium / Q000097:blood; D004247:DNA / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007150:Immunohistochemistry; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress; D011003:Ploidies; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D053545:Spirulina / Q000737:chemistry*
chemical_list: D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen; D020011:Protective Agents; D002857:Chromium; D008315:Malondialdehyde; D004247:DNA; D002374:Catalase; D005978:Glutathione