title: Prevention of food allergy.
abstract: Despite a trend towards delayed weaning, food allergies (FAs) have increased in the past few decades and are now considered a public health concern, resulting in significant morbidity as well as occasional mortality. Whilst genetic factors are clearly important in the development of FA, a rise in FAs has occurred over a short period of time and is therefore unlikely to be due to germ-line genetic changes alone. Thus, it seems plausible that one or more environmental exposures may, via epigenetic changes, result in the interruption of the 'default immunologic state' of tolerance to foods. Strategies are therefore required for the prevention of FA: primary prevention seeks to prevent the onset of IgE-sensitisation; secondary prevention seeks to interrupt the development of FA in IgE-sensitised children; and tertiary prevention seeks to reduce the expression of 'end-organ' allergic disease in children with established FA. This chapter will outline the major findings in this field, with the aim of equipping the clinician with an evidence-based approach to a burgeoning yet poorly understood clinical problem. We also highlight the methodological challenges hindering the interpretation of existing FA studies. Fortunately, there are now robust studies underway, the results of which are expected to guide public health recommendations with respect to how and when to introduce major allergenic foods to children, regardless of allergic risk.
authors.affiliation: Department of Paediatric Allergy, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Teresa
authors.initials: T
authors.lastname: Tsakok
authors.forename: George
authors.initials: G
authors.lastname: Du Toit
authors.forename: Gideon
authors.initials: G
authors.lastname: Lack
mesh_terms: D004032:Diet; D004035:Diet Therapy; D019587:Dietary Supplements; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007225:Infant Food; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena