title: Adult social behavior with familiar partners following neonatal amygdala or hippocampus damage.
abstract: The social behavior in a cohort of adult animals who received ibotenic acid lesions of the amygdala (4 female, 3 male) or hippocampus (5 female, 3 male) as neonates, and sham-operated controls (4 female, 4 male) was evaluated in their home environments with the familiar opposite sex monkey (pair-mate) with whom they were housed. Amygdala-lesioned animals spent less time with their familiar partners and engaged in higher frequencies of stress-related behaviors than control animals. Hippocampus-lesioned animals spent significantly more time socially engaging their pair-mates than both control and amygdala-lesioned animals. These results suggest that early damage to the amygdala or hippocampus subtly alter patterns of adult social behavior in a familiar context and stand in sharp contrast to extant studies of early damage to the amygdala or hippocampus and to the more dramatically altered patterns of behavior observed after damage to the adult amygdala.
authors.affiliation: California National Primate Research Center, University of California Davis.
authors.forename: Gilda
authors.initials: G
authors.lastname: Moadab
authors.affiliation: California National Primate Research Center, University of California Davis.
authors.forename: Eliza
authors.initials: E
authors.lastname: Bliss-Moreau
authors.affiliation: The MIND Institute, Center for Neuroscience, California National Primate Research Center.
authors.forename: David G
authors.initials: DG
authors.lastname: Amaral
mesh_terms: D000679:Amygdala / Q000254:growth & development / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000473:pathology / Q000503:physiopathology; D001522:Behavior, Animal / Q000502:physiology*; D015331:Cohort Studies; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000254:growth & development / Q000473:pathology / Q000503:physiopathology*; D006799:Housing, Animal; D007051:Ibotenic Acid; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging; D008297:Male; D021641:Recognition, Psychology / Q000502:physiology*; D012890:Sleep / Q000502:physiology; D012919:Social Behavior; D013997:Time Factors
chemical_list: D007051:Ibotenic Acid