title: The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle.
abstract: The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection.
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. caleb.mckinney@nih.gov.
authors.forename: Caleb C
authors.initials: CC
authors.lastname: McKinney
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. katherine.hussmann@nih.gov.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Hussmann
authors.affiliation: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. amcbride@nih.gov.
authors.forename: Alison A
authors.initials: AA
authors.lastname: McBride
mesh_terms: D004249:DNA Damage; D004260:DNA Repair; D004279:DNA, Viral / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D027383:Papillomaviridae / Q000502:physiology*; D014779:Virus Replication
chemical_list: D004279:DNA, Viral
keywords: DNA damage response; DNA repair; HPV; episome; homologous recombination; keratinocyte; papillomavirus; partitioning; replication; replication foci