title: Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis.
abstract: This study was conducted in order to investigate the implications of the R72P polymorphism in the TP53 gene in breast cancer risk. The enlightenment of this matter might provide a piece of information about the potential implications of this polymorphism in patient risk. A meta-analysis was conducted considering a large sample size from studies with conflicting results on the R72P polymorphism in breast cancer patients. Relevant studies were selected from PubMed and SciELO databases for data extraction and statistical analysis. Database was built according to the continent and considering the genotype frequencies, sample size and genotyping methodology. The dominant models (RR vs RP + PP and RR + RP vs. PP), homozygous (RR vs. PP), heterozygous (RR vs. RP and RP vs. PP) and the allele (R vs. P) were used. Genotype frequencies were summarized and evaluated by χ(2) test of heterogeneity in 2×2 contingency tables with 95% CIs. Odds Ratios (OR) were calculated with a fixed-effect model (Mantel-Haenszel) or a random-effect model (DerSimonian-Laird) if the studies were considered homogeneous (P > 0.05) or heterogeneous (P < 0.05), respectively, using BioEstat® 5.0 software. Supported by a large sample size composed by 25,629 cases and 26,633 controls from 41 studies, we found significant association between the R72P polymorphism in the TP53 gene and the breast cancer risk. The overall data shows an increased risk due to the P allele dominant model, but not in Asia where the risk was associated with the R allele and R dominant model.
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Av. Universitária 1.069, Setor Universitário, Goiânia, Goiás CEP 74.605-010 Brazil.
authors.forename: Meire Luzia
authors.initials: ML
authors.lastname: Gonçalves
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Av. Universitária 1.069, Setor Universitário, Goiânia, Goiás CEP 74.605-010 Brazil.
authors.forename: Sarah Moreira
authors.initials: SM
authors.lastname: Borja
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, Goiás CEP 74605-080 Brazil.
authors.forename: Jacqueline Andréia Bernardes Leão
authors.initials: JA
authors.lastname: Cordeiro
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Av. Universitária 1.069, Setor Universitário, Goiânia, Goiás CEP 74.605-010 Brazil ; Laboratório de Oncogenética e Radiobiologia, Hospital Araújo Jorge, Associação de Combate ao Câncer em Goiás, Goiânia, Goiás CEP 74605-070 Brazil ; Programa de Pós-Graduação Stricto Sensu em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás CEP 74065-140 Brazil.
authors.forename: Vera Aparecida
authors.initials: VA
authors.lastname: Saddi
authors.affiliation: Unidade Universitária de Ciências Exatas e Tecnológicas, Universidade Estadual de Goiás, Anápolis, Goiás CEP 75132-400 Brazil.
authors.forename: Flávio Monteiro
authors.initials: FM
authors.lastname: Ayres
authors.affiliation: Programa de Pós-Graduação Stricto Sensu em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás CEP 74065-140 Brazil.
authors.forename: Cesar Augusto Sam Tiago
authors.initials: CA
authors.lastname: Vilanova-Costa
authors.affiliation: Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Av. Universitária 1.069, Setor Universitário, Goiânia, Goiás CEP 74.605-010 Brazil ; Programa de Pós-Graduação Stricto Sensu em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás CEP 74065-140 Brazil.
authors.forename: Antonio Márcio Teodoro Cordeiro
authors.initials: AM
authors.lastname: Silva
keywords: Arg72Pro; Breast cancer; Genetic susceptibility; R72P; Single nucleotide polymorphism; p53