title: Expression of Vimentin and Ki-67 Proteins in Cervical Squamous Cell Carcinoma and their Relationships with Clinicopathological Features.
abstract: OBJECTIVE
  To investigate the expression of vimentin and Ki-67 proteins in cervical squamous cell carcinoma (CSCC) and their relationships with patient clinicopathological features.
  
  
  METHODS
  Fifty-seven CSCC samples archived in Department of Pathology in the First Affiliated Hospital of Wenzhou Medical University were selected. The expression of vimentin and Ki-67 proteins in CSCC tissue were detected using immunohistochemical SP method, and correlations between them and their relationships with clinicopathological features were analyzed.
  
  
  RESULTS
  Among 57 CSCC tissues, there were 43 with positive expression of Vimentin, and the positive rate was 75.4%; there were 57 cases with positive expression of Ki-67, and the positive rate came up to 100.0%. The results of Pearson correlation analysis displayed that the expression of vimentin had a significantly-positive correlation with Ki-67 in CSCC tissue (r=0.984, co0.000). The expression of both Ki-67 and vimentin was intimately associated with the presence or absence of local invasion and lymph node metastasis as well as differentiated degrees of the tumor (P=0.003, 0.017, 0.000; P=0.001, 0.008, 0.003) instead of the age, tumor size and clinical staging (P>0.05).
  
  
  CONCLUSIONS
  Epithelial-mesenchymal transition (EMT) tends to appear in poorly-differentiated CSCC tissue, and the up-regulation of vimentin expression is accompanied by high expression of Ki-67, suggesting that invasion and metastasis readily occur in these tumor cells.
authors.affiliation: Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China E-mail : baokang1124@sina.cn.
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Yu
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Zheng
authors.forename: Ying
authors.initials: Y
authors.lastname: Bao
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000556:secondary*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000473:pathology*; D014746:Vimentin / Q000032:analysis*
chemical_list: D019394:Ki-67 Antigen; D014746:Vimentin