title: Neurodevelopmental outcome at seven years in term, acidotic newborns.
abstract: The objective was to follow up a cohort of acidotic full-term infants with or without hypoxic ischemic encephalopathy (HIE) and determine if at 7 years they displayed any neurodevelopmental delays. Children (n=44) were divided according to those with mild (n=25) or severe (n=19) acidosis and were then further subdivided into those with or without HIE. Participants were assessed using the Wechsler Intelligence Scale for Children (WISC-IVUK) and Achenbach Child Behaviour Checklist (CBCL). No differences in WISC-IVUK scores in children without HIE irrespective of the cord pH values were found. Children with HIE grade I scored significantly higher in perceptual reasoning than those with grade III (p<0.01). CBCL scores revealed no differences between groups. Findings suggest evidence of impairment at school-age that correlates with the degree of encephalopathy. Acidosis without the presence of clinical encephalopathy was associated with normal outcome.
authors.forename: M
authors.initials: M
authors.lastname: Diviney
authors.forename: R
authors.initials: R
authors.lastname: Pinnamaneni
authors.forename: J F A
authors.initials: JF
authors.lastname: Murphy
authors.forename: B
authors.initials: B
authors.lastname: Lynch
authors.forename: H
authors.initials: H
authors.lastname: Rushe
authors.forename: C
authors.initials: C
authors.lastname: Madigan
authors.forename: M
authors.initials: M
authors.lastname: Geary
authors.forename: A
authors.initials: A
authors.lastname: Foran
mesh_terms: D000138:Acidosis / Q000150:complications*; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications*; D007231:Infant, Newborn; D008297:Male