title: Review of micro/nanotechnologies for microbial biosensors.
abstract: A microbial biosensor is an analytical device with a biologically integrated transducer that generates a measurable signal indicating the analyte concentration. This method is ideally suited for the analysis of extracellular chemicals and the environment, and for metabolic sensory regulation. Although microbial biosensors show promise for application in various detection fields, some limitations still remain such as poor selectivity, low sensitivity, and impractical portability. To overcome such limitations, microbial biosensors have been integrated with many recently developed micro/nanotechnologies and applied to a wide range of detection purposes. This review article discusses micro/nanotechnologies that have been integrated with microbial biosensors and summarizes recent advances and the applications achieved through such novel integration. Future perspectives on the combination of micro/nanotechnologies and microbial biosensors will be discussed, and the necessary developments and improvements will be strategically deliberated.
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Lim
authors.affiliation: Department of Mechanical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea.
authors.forename: Dogyeong
authors.initials: D
authors.lastname: Ha
authors.affiliation: Department of Mechanical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea.
authors.forename: Jongwan
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea ; Department of Chemical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea.
authors.forename: Sung Kuk
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea ; Department of Mechanical Engineering, Ulsan National Institute of Science and Technology , Ulsan , South Korea.
authors.forename: Taesung
authors.initials: T
authors.lastname: Kim
keywords: bioreactor; micro/nanomaterials; micro/nanotechnology; microbial biosensor; microfluidics; riboswitch; sensory-regulative biosensor