title: [French guidelines for the management of adult sickle cell disease: 2015 update].
abstract: Sickle cell disease is a systemic genetic disorder, causing many functional and tissular modifications. As the prevalence of patients with sickle cell disease increases gradually in France, every physician can be potentially involved in the care of these patients. Complications of sickle cell disease can be acute and chronic. Pain is the main symptom and should be treated quickly and aggressively. In order to reduce the fatality rate associated with acute chest syndrome, it must be detected and treated early. Chronic complications are one of the main concerns in adults and should be identified as early as possible in order to prevent end organ damage. Many organs can be involved, including bones, kidneys, eyes, lungs, etc. The indications for a specific treatment (blood transfusion or hydroxyurea) should be regularly discussed. Coordinated health care should be carefully organized to allow a regular follow-up near the living place and access to specialized departments. We present in this article the French guidelines for the sickle cell disease management in adulthood.
authors.affiliation: Unité des maladies génétiques du globule rouge (UMGGR), service de médecine interne, centre de référence de la drépanocytose, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France; Université Paris-Est Créteil (Upec), avenue du Général-de-Gaulle, 94010 Créteil cedex, France; Équipe 2, IMRB, Inserm U955, Créteil, France. Electronic address: anoosha.habibi@hmn.aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Habibi
authors.affiliation: Service de médecine interne, centre de référence de la drépanocytose, hôpital européen Georges-Pompidou, AP - HP, 20, rue Leblanc, 75908 Paris cedex 15, France; Faculté de médecine, université Paris Descartes, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Arlet
authors.affiliation: Service de médecine interne, centre de référence de la drépanocytose, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris cedex 20, France.
authors.forename: K
authors.initials: K
authors.lastname: Stankovic
authors.affiliation: Unité des maladies génétiques du globule rouge (UMGGR), service de médecine interne, centre de référence de la drépanocytose, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Gellen-Dautremer
authors.affiliation: Faculté de médecine, université Paris Descartes, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Département de biothérapie, centre de référence de la drépanocytose, hôpital Necker - Enfants-malades, AP - HP, 149, rue de Sèvres, 75743 Paris cedex, France.
authors.forename: J-A
authors.initials: JA
authors.lastname: Ribeil
authors.affiliation: Unité des maladies génétiques du globule rouge (UMGGR), service de médecine interne, centre de référence de la drépanocytose, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France; Université Paris-Est Créteil (Upec), avenue du Général-de-Gaulle, 94010 Créteil cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Bartolucci
authors.affiliation: Service de médecine interne, centre de référence de la drépanocytose, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris cedex 20, France; Université Pierre-et-Marie-Curie, 4, place Jussieu, 75005 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Lionnet
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000628:therapy*; D019468:Disease Management; D005602:France; D006801:Humans
keywords: Acute chest syndrome; Blood transfusion; Crise vaso-occlusive; Drépanocytose; Hydroxyurea; Hydroxyurée; Sickle cell disease; Syndrome thoracique aigu; Transfusion sanguine; Vaso-occlusive crisis