title: Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.
abstract: The synthesis of the diaryl ether subunits of the marine natural products chrysophaentin A, E and F is described. These natural prodcuts feature tetrasubstituted benzene rings with complex substitution patterns. The central strategy involves an SNAr reaction between a complex phenol and a polysubstituted fluoronitrobenzene. Subseqent attempts to construct the unusualE-chloroalkene linkage through several different approaches are also disclosed.
authors.affiliation: Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Brockway
authors.affiliation: Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616.
authors.forename: Charles I
authors.initials: CI
authors.lastname: Grove
authors.affiliation: Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616.
authors.forename: Maximillian E
authors.initials: ME
authors.lastname: Mahoney
authors.affiliation: Department of Chemistry, University of California, One Shields Ave, Davis, CA 95616.
authors.forename: Jared T
authors.initials: JT
authors.lastname: Shaw
keywords: Chrysophaentin; Claisen; FtsZ; Natural Product Synthesis; SNAr