title: Differing relationship between hypercholesterolemia and a bicuspid aortic valve according to the presence of aortic valve stenosis or aortic valve regurgitation.
abstract: OBJECTIVE
  To assess the difference in hyperlipidemia between patients with bicuspid aortic valve (BAV) and those with a normal aortic valve (NAV), and to compare aortic valve stenosis (AS), with aortic valve regurgitation (AR).
  
  
  METHODS
  Among 32 patients with BAV and 142 patients with NAV who underwent aortic valve replacement, 81 patients had AR and 91 patients had AS. The preoperative clinical characteristics were compared between the BAV and NAV patients. Patients with replacement of the ascending aorta were included, and those who underwent combined valvular surgery, coronary artery bypass grafting, or statin treatment were excluded.
  
  
  RESULTS
  The proportions of females patients (p = 0.42), patients with diabetes (p = 0.26) and patients on dialysis (p = 0.69) were similar in the two groups. Mean age was significantly lower, the mean diameter of the ascending aorta was significantly larger, and the rate of surgical intervention for the ascending aorta was significantly higher in the BAV group than in the NAV group (all p < 0.0001). The mean levels of low-density lipoprotein cholesterol (LDL) (p < 0.0001) and total cholesterol (TC) (p = 0.0003) were significantly higher in the BAV group than in the NAV group, in the analysis of only patients with AS, whereas these levels did not differ significantly between the groups, when only patients with AR were considered.
  
  
  CONCLUSIONS
  BAV with AS is associated with hypercholesterolemia. However, BAV with AR was not associated with hypercholesterolemia.
authors.affiliation: Department of Cardiovascular Surgery, Tokyo Heart Center, 5-4-12 Kitashinagawa, Shinagawa-ku, Tokyo, 140-0001, Japan, prendo@tokyoheart.or.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Endo
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nabuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okuyama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Muto
authors.forename: Susumu
authors.initials: S
authors.lastname: Hiranuma
authors.forename: Takuya
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Joji
authors.initials: J
authors.lastname: Hosokawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Enjoji
authors.forename: Yumi
authors.initials: Y
authors.lastname: Shimura
authors.forename: Osamu
authors.initials: O
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000601:surgery; D001021:Aortic Valve / Q000002:abnormalities* / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000601:surgery; D000082882:Bicuspid Aortic Valve Disease; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications* / Q000601:surgery; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides