title: Chronic lymphocytic leukemia and the Warburg effect.
abstract: In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
authors.affiliation: HOSPITAL SANTA CREU I SANT PAU.
authors.forename: Carol
authors.initials: C
authors.lastname: Moreno
mesh_terms: D006019:Glycolysis; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D051880:Receptors, Notch / Q000502:physiology*; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D051880:Receptors, Notch