title: Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.
abstract: Racemic 1'-homo-3'-isoazanucleosides have been obtained by microwave-assisted 1,3-dipolar cycloaddition of 3,5-disubstituted proline derivative (±)-2 with different alkynes. The compounds obtained were evaluated for their cytotoxic activities in vitro against human breast carcinoma cell lines (MCF-7), human ovary carcinoma cell lines (A2780) and human lung carcinoma cell lines (NCI-H460).
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Ferreira da Costa
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain; Instituto de Farmacia Industrial, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain.
authors.forename: Xerardo
authors.initials: X
authors.lastname: García-Mera
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain; Instituto de Farmacia Industrial, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain. Electronic address: molga.caamano@usc.es.
authors.forename: Olga
authors.initials: O
authors.lastname: Caamaño
authors.affiliation: Instituto de Farmacia Industrial, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain; Centro de Investigación CIMUS, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Brea
authors.affiliation: Instituto de Farmacia Industrial, Facultade de Farmacia, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Spain; Centro de Investigación CIMUS, Campus Vida s/n, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Loza
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D061565:Cycloaddition Reaction; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008872:Microwaves; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides; D014230:Triazoles
keywords: Alkynes; Anticancer; Azanucleosides; Huisgen cycloaddition; Synthesis