title: Hypertension linked to PDE3A activation.
abstract: A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.
authors.affiliation: Institute of Pharmaceutical Science, King's College London, London, UK, and Mironid, Ltd., BioCity Scotland, Newhouse, UK.
authors.forename: Miles
authors.initials: M
authors.lastname: Houslay
mesh_terms: D054684:Cyclic Nucleotide Phosphodiesterases, Type 3 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics
chemical_list: D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; C517287:PDE3A protein, human