title: Development of adrenal cortex zonation.
abstract: The human adult adrenal cortex is composed of the zona glomerulosa (zG), zona fasciculata (zF), and zona reticularis (zR), which are responsible for production of mineralocorticoids, glucocorticoids, and adrenal androgens, respectively. The final completion of cortical zonation in humans does not occur until puberty with the establishment of the zR and its production of adrenal androgens; a process called adrenarche. The maintenance of the adrenal cortex involves the centripetal displacement and differentiation of peripheral Sonic hedgehog-positive progenitors cells into zG cells that later transition to zF cells and subsequently zR cells.
authors.affiliation: Internal Medicine, Medical School, University of Michigan, 109 Zina Pitcher Place, 1860 BSRB, Ann Arbor, MI 48109, USA.
authors.forename: Yewei
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Internal Medicine, Medical School, University of Michigan, 109 Zina Pitcher Place, 1860 BSRB, Ann Arbor, MI 48109, USA.
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Lerario
authors.affiliation: Internal Medicine, Medical School, University of Michigan, 109 Zina Pitcher Place, 1860 BSRB, Ann Arbor, MI 48109, USA; Department of Molecular & Integrative Physiology, University of Michigan, 2560D MSRB II, 1150 W. Medical Center Dr., Ann Arbor, MI 48109-5622, USA.
authors.forename: William
authors.initials: W
authors.lastname: Rainey
authors.affiliation: Endocrine Oncology Program, Center for Organogenesis, University of Michigan, 109 Zina Pitcher Place, 1528 BSRB, Ann Arbor, MI 48109-2200, USA. Electronic address: ghammer@umich.edu.
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hammer
mesh_terms: D000302:Adrenal Cortex / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D000728:Androgens / Q000378:metabolism; D002454:Cell Differentiation; D005938:Glucocorticoids / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D008901:Mineralocorticoids / Q000378:metabolism; D011627:Puberty / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism; D015383:Zona Fasciculata / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D015384:Zona Glomerulosa / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D015385:Zona Reticularis / Q000196:embryology / Q000254:growth & development / Q000378:metabolism
chemical_list: D000728:Androgens; D005938:Glucocorticoids; D053823:Hedgehog Proteins; D008901:Mineralocorticoids
keywords: Adrenal cortex; Development; Steroidogenesis; Zonation