title: Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma.
abstract: Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), a disease with increasing burden in the Western world, especially in white men. Risk factors for BE include obesity, tobacco smoking, and gastroesophageal reflux disease (GERD). EAC is the most common form of esophageal cancer in the United States. Risk factors include GERD, tobacco smoking, and obesity, whereas nonsteroidal antiinflammatory drugs and statins may be protective. Factors predicting progression from nondysplastic BE to EAC include dysplastic changes on esophageal histology and length of the involved BE segment. Biomarkers have shown promise, but none are approved for clinical use.
authors.affiliation: Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, CB#7080, Chapel Hill, NC 27599-7080, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Runge
authors.affiliation: Division of Digestive and Liver Diseases, Columbia University Medical Center, 622 West 168th Street, PH 7W-318D, New York, NY 10032, USA.
authors.forename: Julian A
authors.initials: JA
authors.lastname: Abrams
authors.affiliation: Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, CB#7080, Chapel Hill, NC 27599-7080, USA. Electronic address: nshaheen@med.unc.edu.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Shaheen
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000367:Age Factors; D000428:Alcohol Drinking / Q000453:epidemiology; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D015415:Biomarkers; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000453:epidemiology; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D009765:Obesity / Q000453:epidemiology; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: D015415:Biomarkers
keywords: Barrett’s esophagus; Epithelium; Esophageal adenocarcinoma; Gastroesophageal reflux disease