title: Protective role of Proanthocyanidin in experimental ovarian torsion.
abstract: BACKGROUND
  Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury.
  
  
  METHODS
  Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19.
  
  
  RESULTS
  Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation.
  
  
  CONCLUSIONS
  Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.
authors.affiliation: Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. sule.yildirim@comu.edu.tr.
authors.forename: Şule
authors.initials: Ş
authors.lastname: Yıldırım
authors.affiliation: Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. nacitopaloglu@gmail.com.
authors.forename: Naci
authors.initials: N
authors.lastname: Topaloğlu
authors.affiliation: Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. mustafa5060@gmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tekin
authors.affiliation: MD, Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey. ademkucuk81@hotmail.com.
authors.forename: Adem
authors.initials: A
authors.lastname: Küçük
authors.affiliation: Associate Professor, Department of Pathology, Düzce University Medical Faculty, Düzce, Turkey. drhavvaerdem@hotmail.com.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.affiliation: Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. benimmesut@hotmail.com.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbaş
authors.affiliation: Assistant Professor, Department of Emergency Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. ahmetyildirim@comu.edu.tr.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yıldırım
keywords: Fertility; Ischemia Reperfusion; Ovarian torsion; Proanthocyanidinin