title: Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies.
abstract: In the pathogenesis of multiple sclerosis (MS), B cell/antibody-related mechanisms have recently received attention. To investigate the role of autoantibody in MS, we performed SEREX which can identify autoantibody cyclopedically. We identified serum antibodies against cytoskeletal protein talin1, and the levels of whom were remarkably higher in 39 MS than 43 normal controls (P < 0.01) and 35 disease controls (P = 0.06), and in MS patients without oligoclonal bands than ones with them. Moreover, we found negative-correlations between serum anti-talin1 antibody and IgG index in MS (P = 0.03). Anti-talin1 antibody exists in MS patients' sera, which may have some protective factor.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Muto
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: morim@faculty.chiba-u.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Takaki
authors.initials: T
authors.lastname: Hiwasa
authors.affiliation: Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takiguchi
authors.affiliation: Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Iwadate
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Uzawa
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Uchida
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Masuda
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D018797:Cell Cycle Proteins / Q000276:immunology / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000276:immunology / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004185:Disability Evaluation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000473:pathology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016608:Talin / Q000276:immunology*; D000099259:N-myc Downstream-Regulated Gene 1 Protein
chemical_list: D001323:Autoantibodies; D018797:Cell Cycle Proteins; D053487:DEAD-box RNA Helicases; D004247:DNA; D047908:Intracellular Signaling Peptides and Proteins; D016608:Talin; D000099259:N-myc Downstream-Regulated Gene 1 Protein; C518832:TLN1 protein, human; C498428:DDX39A protein, human
keywords: DDX39 protein; IgG index; Multiple sclerosis; Oligoclonal bands; SEREX; TLN1 protein