title: New insights into the role of podoplanin in epithelial-mesenchymal transition.
abstract: Podoplanin is a small mucin-like transmembrane protein expressed in several adult tissues and with an important role during embryogenesis. It is needed for the proper development of kidneys and lungs as well as accurate formation of the lymphatic vascular system. In addition, it is involved in the physiology of the immune system. A wide variety of tumors express podoplanin, both in the malignant cells and in the stroma. Although there are exceptions, the presence of podoplanin results in poor prognosis. The main consequence of forced podoplanin expression in established and tumor-derived cell lines is an increase in cell migration and, eventually, the triggering of an epithelial-mesenchymal transition, whereby cells acquire a fibroblastoid phenotype and increased motility. We will examine the current status of the role of podoplanin in the induction of epithelial-mesenchymal transition as well as the different interactions that lead to this program.
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Renart
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Carrasco-Ramírez
authors.affiliation: Laboratorio Andaluz de Reprogramación Celular, Sevilla, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernández-Muñoz
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: Ester
authors.initials: E
authors.lastname: Martín-Villar
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Montero
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: María M
authors.initials: MM
authors.lastname: Yurrita
authors.affiliation: Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Quintanilla
mesh_terms: D000328:Adult; D000818:Animals; D002465:Cell Movement; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D000098853:Podoplanin
chemical_list: D008562:Membrane Glycoproteins; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C117468:PDPN protein, human
keywords: Actin cytoskeleton; CD44; CLEC-2; Cancer; Cell motility; Cell signaling; ERM; Protein–protein interactions