title: Genetic background of skin barrier dysfunction in the pathogenesis of psoriasis vulgaris.
abstract: Psoriasis is a common inflammatory skin disease. It is known to be a complex condition with multifactorial mode of inheritance, however the associations between particular pathogenic pathways remain unclear. A novel report on the pathogenesis of psoriasis has recently included the genetic determination of the skin barrier dysfunction. In this paper, we focus on specific genetic variants associated with formation of the epidermal barrier and their role in the complex pathogenesis of the disease.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Marta
authors.initials: M
authors.lastname: Stawczyk-Macieja
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Aneta
authors.initials: A
authors.lastname: Szczerkowska-Dobosz
authors.affiliation: Department of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Zbigniew Jankowski MD, PhD.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rębała
authors.affiliation: Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland. Head of the Department: Prof. Roman Nowicki MD, PhD.
authors.forename: Dorota
authors.initials: D
authors.lastname: Purzycka-Bohdan
keywords: epidermal differentiation complex; late cornified envelope; psoriasis