title: Cardiopoietic index predicts heart repair fitness of patient-derived stem cells.
abstract: BACKGROUND
  Stem cell therapy shows promise for regeneration in heart disease, yet interpatient variability challenges implementation into practice.
  
  
  OBJECTIVE
  To establish a biomarker profile, predictive of reparative potential in patient-derived progenitors, human mesenchymal stem cells were isolated from patients undergoing coronary artery bypass grafting.
  
  
  METHODS
  Stem cell delivery postinfarction translated into divergent benefit, distinguishing reparative from nonreparative populations.
  
  
  RESULTS
  While the nonreparative subtype was characterized by low expression of cardiac transcription factors, reparative human mesenchymal stem cells demonstrated high expression of cardiac transcription factors.
  
  
  CONCLUSIONS
  This index of factors (cardiopoietic index) was found sensitive and specific in predicting impact of stem cell benefit on left ventricular function. The cardiopoietic index thus offers a tool to screen stem cell fitness for heart repair prior to intervention.
authors.affiliation: Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA.
authors.forename: Ruben
authors.initials: R
authors.lastname: Crespo-Diaz
authors.affiliation: Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Yamada
authors.affiliation: Cardiovascular Center, OLV Hospital, Aalst, Belgium.
authors.forename: Jozef
authors.initials: J
authors.lastname: Bartunek
authors.affiliation: Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA.|Department of Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: Perez-Terzic
authors.affiliation: Celyad BioSciences, Mont-Saint-Guibert, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: de Waele
authors.affiliation: Celyad BioSciences, Mont-Saint-Guibert, Belgium.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Mauën
authors.affiliation: Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Terzic
authors.affiliation: Center for Regenerative Medicine, Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Molecular Pharmacology & Experimental Therapeutics, Rochester, MN 55905, USA.
authors.forename: Atta
authors.initials: A
authors.lastname: Behfar
mesh_terms: D000368:Aged; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D014183:Transplantation, Heterologous
chemical_list: D015415:Biomarkers
keywords: cardiopoiesis; cardiopoietic stem cells; heart failure; mesenchymal; regenerative medicine; stem cells