title: A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.
abstract: A copper-catalyzed coupling reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK) http://www.leygroup.ch.cam.ac.uk.
authors.forename: Jian-Siang
authors.initials: JS
authors.lastname: Poh
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK) http://www.leygroup.ch.cam.ac.uk.
authors.forename: Duc N
authors.initials: DN
authors.lastname: Tran
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK) http://www.leygroup.ch.cam.ac.uk.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.affiliation: Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340 (USA).
authors.forename: Joel M
authors.initials: JM
authors.lastname: Hawkins
authors.affiliation: Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK) http://www.leygroup.ch.cam.ac.uk. svl1000@cam.ac.uk.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003979:Diazonium Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D013696:Temperature
chemical_list: D000466:Alkadienes; D000480:Alkynes; D003979:Diazonium Compounds; C030011:carbene; C025947:propadiene; D003300:Copper; D008697:Methane
keywords: allenes; carbenes; copper; diazo compounds; flow chemistry