title: [Snake venom proteins related to "vascular endothelial growth factor": new tools for therapeutic angiogenesis].
abstract: The Vascular Endothelial Growth Factor "VEGF" plays a pivotal role in the stimulation of angiogenesis. The VEGF isoforms (A-D) and PlGF act in a coordinate fashion to develop the vascular network. Numerous proteins closely related in structure and function to VEGF-A have been reported and were grouped in the VEGF family. Some predators make use of VEGF-like molecules with devastating results for their prey. VEGF-E, investigated in 1994, is encoded by the parapoxvirus (Orf virus). VEGF-F is a common term designating molecules which were isolated from snake venom (also known as svVEGF). These proteins are disulphide-linked homodimers of 110 amino acids each and have a molecular weight of approximately 25 kDa. Their primary structures show approximately 50% identity to VEGF-A. However, unlike VEGF-A, they do not contain any N-linked glycosylation sites. They interact with heparin but have a different binding domain from that of VEGF-A. Among species, these svVEGFs vary extensively in amino acid sequences and in receptor-binding specificities towards endogenous VEGF receptors. Understanding the properties that determine the specificity of these interactions could improve our knowledge of the VEGF-receptor interactions. This knowledge is essential to the development of new drugs in angiogenesis. This knowledge is essential to the development of new drugs in angiogenesis.
authors.affiliation: Laboratoire d'Epidémiologie Moléculaire et Pathologie Expérimentale Appliquées aux Maladies Infectieuses LR11IPT04, Institut Pasteur de Tunis, 13 Place Pasteur, BP 74, 1002 Tunis-Belvédère, Tunisie. zohra.aloui@pastueur.rns.tn
authors.forename: Z
authors.initials: Z
authors.lastname: Aloui
authors.forename: K
authors.initials: K
authors.lastname: Essafi-Benkhadir
authors.forename: H
authors.initials: H
authors.lastname: Karoui
authors.forename: A
authors.initials: A
authors.lastname: Gasmi
mesh_terms: D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D012910:Snake Venoms / Q000627:therapeutic use*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology / Q000627:therapeutic use*
chemical_list: D012910:Snake Venoms; D042461:Vascular Endothelial Growth Factor A