title: Rhenium and Technetium Complexes with Pentadentate Thiocarbamoylbenzamidines: Steps toward Bioconjugation.
abstract: Thiocarbamoylbenzimidoyl chlorides, PhC(Cl)═N-(C═S)-NR(1)R(2), react with 2-(iminodiacetic acid)benzylamine under formation of the potentially pentadentate ligands H3L (R(1), R(2) = Et) and H3L-COOEt (R(1) = Me, R(2) = C6H4-4-COOEt) in high yields. Hydrolysis of H3L-COOEt in NaOH/MeOH gives quantitatively another benzamidine ligand H3L-COOH. The novel ligands readily react with (NBu4)[MOCl4] (M = Re, Tc) under formation of stable complexes with the general composition [MO(L)], in which they are triply deprotonated and fully occupy the remaining five coordination positions of the {MO}(3+) cores. In a "proof-of-principle" reaction for possible bioconjugations, the complex [ReO(L-COOH)] has been labeled with triglycine ethyl ester in high yields.
authors.affiliation: †Department of Chemistry, Hanoi University of Science, 19 Le Thanh Tong, Hanoi, Vietnam.
authors.forename: Hung Huy
authors.initials: HH
authors.lastname: Nguyen
authors.affiliation: †Department of Chemistry, Hanoi University of Science, 19 Le Thanh Tong, Hanoi, Vietnam.|‡Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstrasse 34-36, D-14195 Berlin, Germany.
authors.forename: Chien Thang
authors.initials: CT
authors.lastname: Pham
authors.affiliation: ‡Institute of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstrasse 34-36, D-14195 Berlin, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Abram
mesh_terms: D001550:Benzamidines / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
chemical_list: D001550:Benzamidines; D009942:Organometallic Compounds; D012211:Rhenium; D013667:Technetium; C032157:benzamidine