title: A Notch above Sonic Hedgehog.
abstract: Cell fate specification requires tightly orchestrated cellular responses to extracellular factors. In this issue of Developmental Cell, Kong et al. (2015) reveal that Notch signaling activity facilitates the interpretation of Sonic hedgehog (Shh) signals by regulating signaling in the cilia, influencing fate specification of neural stem and progenitor cells.
authors.affiliation: Department of Neurology, Programs in Neuroscience and Developmental and Stem Cell Biology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158.
authors.forename: Odessa
authors.initials: O
authors.lastname: Yabut
authors.affiliation: Department of Neurology, Programs in Neuroscience and Developmental and Stem Cell Biology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158. Electronic address: sam.pleasure@ucsf.edu.
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Pleasure
authors.affiliation: Department of Neurology, Programs in Neuroscience and Developmental and Stem Cell Biology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158; College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Republic of Korea.
authors.forename: Keejung
authors.initials: K
authors.lastname: Yoon
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002923:Cilia / Q000502:physiology*; D053823:Hedgehog Proteins / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D051880:Receptors, Notch / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D053823:Hedgehog Proteins; D051880:Receptors, Notch