title: Simultaneous Determination of Nitrofuran Metabolites and Chloramphenicol in Shrimp with a Single Extraction and LC-MS/MS Analysis.
abstract: A method has been developed to quantify the nitrofuran metabolites 3-amino-5-morphorinomethyl-1,3-oxazolidinone, 3-amino-oxazolidinone, 1-aminohydantoin, and semicarbazide, as well as chloramphenicol in shrimp with a single extraction procedure followed by LC-MS/MS analysis. Dynamic selected reaction monitoring with positive and negative ionization mode switching was used. The method LODs were 0.5 ng/g for the nitrofuran metabolites and 0.3 ng/g for chloramphenicol.
authors.affiliation: U.S. Food and Drug Administration, 11510 W 80th St, Lenexa, KS 66214, USA.
authors.forename: Aref
authors.initials: A
authors.lastname: El-Demerdash
authors.forename: Fenhong
authors.initials: F
authors.lastname: Song
authors.forename: Robin K
authors.initials: RK
authors.lastname: Reel
authors.forename: Judy
authors.initials: J
authors.lastname: Hillegas
authors.forename: Robert E
authors.initials: RE
authors.lastname: Smith
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002701:Chloramphenicol / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D009581:Nitrofurans / Q000032:analysis*; D033561:Penaeidae / Q000737:chemistry*; D012015:Reference Standards; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D009581:Nitrofurans; D002701:Chloramphenicol