title: A Silver(I)-Catalyzed Intramolecular Ficini's [2 + 2] Cycloaddition Employing Ynamides.
abstract: An intramolecular [2 + 2] cycloaddition usingN-sulfonyl substituted ynamides tethered to an enone motif is described here. This thermally driven [2 + 2] cycloaddition manifold can be catalyzed effectively using AgNTf2, and represents the first examples of an intramolecular Ficini reaction.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001 P. R. China ; Division of Pharmaceutical Sciences and Department of Chemistry, School of Pharmacy, University of Wisconsin Madison, WI 53705 USA.
authors.forename: Xiao-Na
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, School of Pharmacy, University of Wisconsin Madison, WI 53705 USA.
authors.forename: Zhi-Xiong
authors.initials: ZX
authors.lastname: Ma
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, School of Pharmacy, University of Wisconsin Madison, WI 53705 USA ; School of Pharmaceutical Science and Technology, Key Laboratory for Modern Drug Delivery and High-Efficiency Tianjin University, Tianjin, 300072 P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, School of Pharmacy, University of Wisconsin Madison, WI 53705 USA.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
keywords: AgNTf2; Intramolecular [2 + 2] cycloaddition; and electrocyclic ring-opening; the Ficini reaction; ynamides