title: Base-Promoted β-C(sp(3))-H Functionalization of Enaminones: An Approach to Polysubstituted Pyridines.
abstract: A convenient "one-pot" base-promoted synthesis of polysubstituted pyridines from 1-arylethylamines and ynones through the direct β-C(sp(3))-H functionalization of enaminones under metal-free conditions has been developed. An intermolecular Michael addition reaction and an intramolecular condensation were involved in this procedure, which features high regioselectivity, high efficiency, and environmental friendliness. Various polysubstituted pyridines were provided in up to 92% yield for 34 examples.
authors.forename: Jinhai
authors.initials: J
authors.lastname: Shen
authors.forename: Dingding
authors.initials: D
authors.lastname: Cai
authors.forename: Changsheng
authors.initials: C
authors.lastname: Kuai
authors.forename: Yunqi
authors.initials: Y
authors.lastname: Liu
authors.forename: Ming'e
authors.initials: M
authors.lastname: Wei
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D003500:Cyclization; D005021:Ethylamines / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005021:Ethylamines; D008670:Metals; D011725:Pyridines