title: Serial assessment of the index of microcirculatory resistance during primary percutaneous coronary intervention comparing manual aspiration catheter thrombectomy with balloon angioplasty (IMPACT study): a randomised controlled pilot study.
abstract: Utilising a novel study design, we evaluated serial measurements of the index of microcirculatory resistance (IMR) in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) to assess the impact of device therapy on microvascular function, and determine what proportion of microvascular injury is related to the PPCI procedure, and what is an inevitable consequence of STEMI.
  
  
  
  41 patients undergoing PPCI for STEMI were randomised to balloon angioplasty (BA, n=20) or manual thrombectomy (MT, n=21) prior to stenting. Serial IMR measurements, corrected for collaterals, were recorded at baseline and at each stage of the procedure. Microvascular obstruction (MVO) and infarct size at 24 h and 3 months were measured by troponin and cardiac MRI (CMR).
  
  
  
  IMR did not change significantly following PPCI, but patients with lower IMR values (<32, n=30) at baseline had a significant increase in IMR following PPCI (baseline: 21.2±7.9 vs post-stent: 33.0±23.7, p=0.01) attributable to prestent IRA instrumentation (baseline: 21.7±8.0 vs post-BA or MT: 36.9±25.9, p=0.006). Post-stent IMR correlated with early MVO on CMR (p=0.01). There was no significant difference in post-stent IMR, presence of early MVO or final infarct size between patients with BA and patients treated with MT.
  
  
  
  Patients with STEMI and less microcirculatory dysfunction may be susceptible to acute iatrogenic microcirculatory injury from prestent coronary devices. MT did not appear to be superior to BA in maintaining microcirculatory integrity when the guide wire partially restores IRA flow during PPCI.
  
  
  
  ISRCTN31767278.
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hoole
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Jaworski
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Brown
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Liam M
authors.initials: LM
authors.lastname: McCormick
authors.affiliation: Department of Radiology , Papworth Hospital , Cambridge , UK.
authors.forename: Bobby
authors.initials: B
authors.lastname: Agrawal
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Clarke
authors.affiliation: Department of Interventional Cardiology , Papworth Hospital , Cambridge , UK.
authors.forename: Nick E J
authors.initials: NE
authors.lastname: West