title: Determination of whether screening tests for chronic atrophic gastritis really has a positive predictive value.
abstract: Intestinal‑type gastric adenocarcinomas are preceded by precancerous lesions, which begin with chronic atrophic gastritis. Over the last few years, multiple serological screening techniques have been performed and commercialized for the diagnosis of chronic atrophic gastritis. In the present study, 123 patients were recruited at the International Cancer Institute 'G. Pascale' Foundation (Naples, Italy) to test commercial kits for the serological determination of chronic atrophic gastritis, supported by histological analysis, according to the International Group of Gastroenterologists 'Operative Link for Gastritis Assessment Staging System'. The results revealed a significant discrepancy between serological screening and histological evaluation in 10.6% of patients, which highlighted the dubious positive predictive value of commercial serological screening kits.
authors.affiliation: Division of Laboratory Medicine, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Flaviano
authors.initials: F
authors.lastname: Di Paola
authors.affiliation: Division of Diagnostic and Operative Endoscopy, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: D'Angelo
authors.affiliation: Division of Pathology, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Tatangelo
authors.affiliation: Division of Laboratory Medicine, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Barchiesi
authors.affiliation: Division of Laboratory Medicine, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Rizzo
authors.affiliation: Division of Pathology, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Cantile
authors.affiliation: Division of Pathology, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.affiliation: Division of Laboratory Medicine, National Institute of Tumors G. Pascale Foundation, Institute for Hospitalization and Treatment for Scientific Purposes, Naples I‑80131, Italy.
authors.forename: Ernesta
authors.initials: E
authors.lastname: Cavalcanti
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood* / Q000175:diagnosis* / Q000473:pathology; D016481:Helicobacter Infections / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D012698:Serologic Tests; D013270:Stomach / Q000382:microbiology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis / Q000473:pathology