title: Cerebral toxoplasmosis in a patient on methotrexate and infliximab for rheumatoid arthritis.
abstract: Cerebral toxoplasmosis is a rare disease predominantly found in immunocompromised hosts. However, cerebral toxoplasmosis has not been frequently described in association with the use of immunosuppressive medications. We herein report a case of cerebral toxoplasmosis in a 76-year-old Caucasian woman on methotrexate and infliximab for rheumatoid arthritis. The patient presented with right facial droop, slurred speech and difficulty walking. In addition to receiving methotrexate and infliximab and owning a cat, she had no other obvious risk factors. Imaging studies were not conclusive; however, brain biopsy confirmed the diagnosis. Serology was positive for anti-toxoplasma immunoglobulin G. Cerebral toxoplasmosis should be included in the differential diagnosis of patients under immunosuppressive medication who present with neurological manifestations.
authors.affiliation: Research Department, HealthEast Care System, USA.
authors.forename: Swaroopa
authors.initials: S
authors.lastname: Pulivarthi
authors.forename: Rwoof A
authors.initials: RA
authors.lastname: Reshi
authors.forename: Carl T
authors.initials: CT
authors.lastname: McGary
authors.forename: Murali Krishna
authors.initials: MK
authors.lastname: Gurram
mesh_terms: D000368:Aged; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002415:Cats; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000069285:Infliximab / Q000009:adverse effects / Q000627:therapeutic use*; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
chemical_list: D007166:Immunosuppressive Agents; D000069285:Infliximab; D008727:Methotrexate