title: TGFβ Induces a Pro-Bone Metastasis Program in Prostate Cancer.
abstract: PMEPA1 is induced by TGFβ and inhibits TGFβ signaling to suppress prostate cancer bone metastasis.
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; C412868:PMEPA1 protein, human; D016212:Transforming Growth Factor beta