title: Higher Prevalence and Distinct Features of Herpes Zoster Infection in Children than Adults with Systemic Lupus Erythematosus.
abstract: Herpes zoster infection was significantly more often observed in children (10%, N = 362) than in adults (4%, N = 1830). At herpes zoster infection diagnosis, disease activity score (8 vs. 3, P = 0.002) was higher in children, and fever (43% vs. 12%, P < 0.0001), nephritis (45% vs. 25%, P = 0.038), anti-double-stranded DNA autoantibodies (76% vs. 15%, P < 0.0001) and low C4 (48% vs. 22%, P = 0.017) were more often observed in children versus adults. Post herpetic neuralgia was less common in children than adults (3% vs. 24%, P =0.005).
authors.affiliation: From the *Division of Rheumatology, and †Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Natali W S
authors.initials: NW
authors.lastname: Gormezano
authors.forename: Clovis A
authors.initials: CA
authors.lastname: Silva
authors.forename: Carini I
authors.initials: CI
authors.lastname: Otsuzi
authors.forename: Diego L
authors.initials: DL
authors.lastname: Barros
authors.forename: Mariana A
authors.initials: MA
authors.lastname: da Silva
authors.forename: Adriana M E
authors.initials: AM
authors.lastname: Sallum
authors.forename: Sandra
authors.initials: S
authors.lastname: Pasoto
authors.forename: Rosa M R
authors.initials: RM
authors.lastname: Pereira
authors.forename: Eloisa
authors.initials: E
authors.lastname: Bonfá
mesh_terms: D000328:Adult; D002648:Child; D006562:Herpes Zoster / Q000150:complications / Q000453:epidemiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology / Q000821:virology; D015995:Prevalence; D012189:Retrospective Studies