title: A compact photometer based on metal-waveguide-capillary: application to detecting glucose of nanomolar concentration.
abstract: Trace analysis of liquid samples has wide applications in life science and environmental monitor. In this paper, a compact and low-cost photometer based on metal-waveguide-capillary (MWC) was developed for ultra-sensitive absorbance detection. The optical-path can be greatly enhanced and much longer than the physical length of MWC, because the light scattered by the rippled and smooth metal sidewall can be confined inside the capillary regardless of the incident-angle. For the photometer with a 7 cm long MWC, the detection limit is improved ~3000 fold compared with that of commercial spectrophotometer with 1 cm-cuvette, owing to the novel nonlinear optical-path enhancement as well as fast sample switching, and detecting glucose of a concentration as low as 5.12 nM was realized with conventional chromogenic reagent.
authors.affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Min
authors.initials: M
authors.lastname: Bai
authors.affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Hao
authors.affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Electronic Science and Technology, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wu
authors.affiliation: Jordan Valley Semiconductors UK Ltd, Shanghai 201206, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
mesh_terms: D015374:Biosensing Techniques; D004784:Environmental Monitoring; D005947:Glucose / Q000737:chemistry / Q000302:isolation & purification*; D008027:Light; D057230:Limit of Detection; D008670:Metals / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D008670:Metals; D005947:Glucose