title: A Compound Inhibits Biofilm Formation of Staphylococcus aureus from Streptomyces.
abstract: Biofilm is one virulence factor of bacteria. It contributes not only to bacterial adherence to many kinds of infection-establishing surfaces, but also to bacterial resistance against antimicrobial agents and antiseptic agents. Thus, inhibitors of bacterial biofilm formation should be useful in the prevention of infections. We found that a culture of Streptomyces sp. strain MC11024 showed inhibitory activity on biofilm formation by Staphylococcus aureus and isolated streptorubin B as an inhibitor of this formation in S. aureus. The biofilm formation of methicillin resistant S. aureus (MRSA) N315 was reduced to less than 30% at 1 µg/mL of streptorubin B, and at this concentration cell growth was not affected. Our study suggests that streptorubin B has the potential to be a leading compound of anti-infectious agents of S. aureus.
authors.affiliation: College of Pharmaceutical Sciences, Ritsumeikan University.
authors.forename: Naomoto
authors.initials: N
authors.lastname: Suzuki
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ohtaguro
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Motoshi
authors.initials: M
authors.lastname: Hirai
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsuo
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Yamada
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Imamura
authors.forename: Tomofusa
authors.initials: T
authors.lastname: Tsuchiya
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity; D056265:Microbial Interactions; D008826:Microbial Sensitivity Tests; D011353:Prodigiosin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; C528939:streptorubin B; D011353:Prodigiosin