title: Curative effect of sesame oil in a rat model of chronic kidney disease.
abstract: OBJECTIVE
  Chronic kidney disease causes a progressive and irreversible loss of renal function. We investigated the curative effect of sesame oil, a natural, nutrient-rich, potent antioxidant, in a rat model of chronic kidney disease.
  
  
  METHODS
  Chronic kidney disease was induced by subcutaneously injecting uni-nephrectomized rats with deoxycorticosterone acetate (DOCA) and 1% NaCl [DOCA/salt] in drinking water. Four weeks later, the rats were gavaged with sesame oil (0.5 or 1 mL/kg per day) for 7 days. Renal injury, histopathological changes, hydroxyl radical, peroxynitrite, lipid peroxidation, Nrf2, osteopontin expression, and collagen were assessed 24 h after the last dose of sesame oil.
  
  
  RESULTS
  Blood urea nitrogen, creatinine, urine volume, and albuminuria were significantly higher in the DOCA/salt treated rats than in control rats. Sesame oil significantly decreased these four tested parameters in DOCA/salt treated rats. In addition, creatinine clearance rate and nuclear Nrf2 expression were significantly decreased in the DOCA/salt treated rats compared to control rats. Sesame oil significantly decreased hydroxyl radical, peroxynitrite level, lipid peroxidation, osteopontin, and renal collagen deposition, but increased creatinine clearance rate and nuclear Nrf2 expression in DOCA/salt treated rats.
  
  
  CONCLUSIONS
  We conclude that supplementation of sesame oil mitigates DOCA/salt induced chronic kidney disease in rats by activating Nrf2 and attenuating osteopontin expression and inhibiting renal fibrosis in rats.
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Chuan-Teng
authors.initials: CT
authors.lastname: Liu
authors.affiliation: Department of Food and Beverage Services, Tainan University of Technology, Tainan, Taiwan.
authors.forename: Se-Ping
authors.initials: SP
authors.lastname: Chien
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Dur-Zong
authors.initials: DZ
authors.lastname: Hsu
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Periasamy
authors.affiliation: Department of Environmental and Occupational Health, National Cheng Kung University, Tainan, Taiwan.|Research Center for Environmental and Occupational Health and Preventive Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ming-Yie
authors.initials: MY
authors.lastname: Liu
mesh_terms: D000419:Albuminuria / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D064791:Desoxycorticosterone Acetate; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005355:Fibrosis; D017665:Hydroxyl Radical / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D009392:Nephrectomy; D053495:Osteopontin / Q000378:metabolism; D030421:Peroxynitrous Acid / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D051436:Renal Insufficiency, Chronic / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012715:Sesame Oil / Q000494:pharmacology*; D012965:Sodium Chloride; D013997:Time Factors
chemical_list: D000975:Antioxidants; D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat; C506897:Spp1 protein, rat; D053495:Osteopontin; D030421:Peroxynitrous Acid; D017665:Hydroxyl Radical; D012965:Sodium Chloride; D064791:Desoxycorticosterone Acetate; D012715:Sesame Oil; D003094:Collagen
keywords: Nrf2; chronic kidney disease; deoxycorticosterone acetate salt; osteopontin; sesame oil