title: New 2-arylbenzofuran metabolite from cell cultures of Morus alba.
abstract: A new 2-arylbenzofuran compound, 5-dehydroxy-moracin U (1), along with 10 known compounds (2-11), were isolated from cell cultures of Morus alba. Their structures were elucidated on the basis of extensive spectroscopic analyses. The anti-inflammatory activity assay of 1-8 showed that 2 and 8 exhibited significant inhibitory effect on LPS-induced NO production with the values of 76.4% and 98.7% at 10(- 5) M, respectively.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of MateriaMedica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tao
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yu
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Dai
mesh_terms: D000893:Anti-Inflammatory Agents; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D009569:Nitric Oxide / Q000096:biosynthesis; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry
chemical_list: C000602158:5-dehydroxy-moracin U; D000893:Anti-Inflammatory Agents; D001572:Benzofurans; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide
keywords: 2-arylbenzofuran; Morus alba; anti-inflammatory activity; cell cultures