title: Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology.
abstract: In the last few years, many prospective studies have demonstrated a clear association between obesity and cancers of the colon and rectum, breast in post-menopausal women, endometrium, kidney, oesophagus and pancreas. Obesity is also associated with a high risk of recurrence and cancer-related death. The pathophysiology of obesity involves various changes that may be implicated in the relationship between obesity and cancer, such as excess inflammatory cytokines and chronic inflammation, hyperinsulinaemia, insulin resistance, and raised leptin and oestrogens. The Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology have signed a cooperation agreement to work together towards reducing the impact of obesity in cancer. Preventing obesity prevents cancer.
authors.affiliation: Servicio de Endocrinología, Hospital del Mar, Passeig Marítim de la Barceloneta 25-29, 08003, Barcelona, Spain. AGoday@parcdesalutmar.cat.|IMIM Institut Mar de Investigacions Mediques, CiberOBN, Passeig Marítim de la Barceloneta 25-29, 08003, Barcelona, Spain. AGoday@parcdesalutmar.cat.
authors.forename: A
authors.initials: A
authors.lastname: Goday
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Barneto
authors.affiliation: Servicio de Endocrinología, Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: García-Almeida
authors.affiliation: Servicio de Oncología Médica, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Blasco
authors.affiliation: Servicio de Endocrinología, Hospital Arnau de Vilanova, Lleida, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lecube
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Grávalos
authors.affiliation: Servicio de Endocrinología, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Martínez de Icaya
authors.affiliation: Servicio de Oncología Médica, Consorcio Hospitalario Provincial de Castellón, Castelló de la Plana, Castellón, Spain.
authors.forename: R
authors.initials: R
authors.lastname: de las Peñas
authors.affiliation: Servicio de Endocrinología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Monereo
authors.affiliation: Servicio de Oncología Médica, Complejo Hospitalario de Pontevedra, Pontevedra, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Vázquez
authors.affiliation: Servicio de Endocrinología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Tenerife, Spain.
authors.forename: J E
authors.initials: JE
authors.lastname: Palacio
authors.affiliation: Servicio de Oncología Médica, Hospital Clínico Universitario San Carlos, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Segura
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D001943:Breast Neoplasms / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000453:epidemiology; D016207:Cytokines / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000453:epidemiology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009369:Neoplasms / Q000453:epidemiology* / Q000378:metabolism / Q000401:mortality; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000453:epidemiology; D012307:Risk Factors; D012955:Societies, Medical; D013030:Spain
chemical_list: D054392:Adipokines; D016207:Cytokines; D007328:Insulin; D007334:Insulin-Like Growth Factor I
keywords: Adipokines; BMI; Fatty acids; IGF1 and 2; Inflammatory cytokines; Insulin