title: [Transport of dinitrosyl iron complexes into animal lungs].
abstract: Effective accumulation of binuclear dinitrosyl iron complexes with glutathione was shown after a subcutaneous para lymphatic injection of an aqueous solution of a dinitrosyl-iron complex into animal lung tissue at a single-dose of 2 micromoles per kilogram two times a day with a 2-h interval. Two hours later after the administration was repeated the concentration of these complexes was 16 micromoles per kilogram of tissue dropping down for the last two hours to 7 micromoles per kilogram of tissue. At one dose injection of binuclear dinitrosyl iron complexes with glutathione their concentration in 2 and 4 hours was two times lower than in the previous experiments. Presumably at the obtained concentration of dinitrosyl iron complexes a bactericidal effect in lungs can be observed against mycobacterium tuberculosis and rapidly proliferating lung tumors.
authors.forename: G N
authors.initials: GN
authors.lastname: Mojokina
authors.forename: N A
authors.initials: NA
authors.lastname: Elistratova
authors.forename: V D
authors.initials: VD
authors.lastname: Mikoyan
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001692:Biological Transport / Q000187:drug effects*; D003545:Cysteine / Q000097:blood; D004578:Electron Spin Resonance Spectroscopy; D005978:Glutathione / Q000008:administration & dosage* / Q000097:blood; D007501:Iron / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry; D009589:Nitrogen Oxides / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D009589:Nitrogen Oxides; C073661:dinitrosyl iron complex; D007501:Iron; D005978:Glutathione; D003545:Cysteine