title: Prolonged Survival in a Case of Chemotherapy-Sensitive Gastric Cancer That Produced Alpha-Fetoprotein and Protein Induced by Vitamin K Antagonist-II.
abstract: The number of reported cases of alpha-fetoprotein (AFP)-producing gastric cancer has gradually increased, with a reported prevalence of 1.3-1.5% of all gastric cancer cases. However, reports of gastric cancer accompanied by elevated serum levels of both AFP and protein induced by vitamin K antagonist-II (PIVKA-II) are rare. The prognosis of AFP- and PIVKA-II-producing gastric cancer has been reported to be very poor because the tumor cells were considered to have a high malignant potential and the cancer progressed rapidly. We described a case of gastric cancer producing AFP and PIVKA-II in which chemotherapy was effective and resulted in prolonged survival, and these two tumor markers were useful for monitoring the treatment response. Routine health screening using upper abdominal ultrasonography revealed hepatic tumors in an apparently healthy 65-year-old man. Whole-body computed tomography (CT) revealed multiple hepatic tumors, and an esophagogastroduodenoscopy (EGD) revealed a Bormann type 3 tumor in the lower stomach. A biopsy specimen confirmed that the tumor was immunohistochemically positive for AFP, PIVKA-II, and human epidermal growth factor receptor 2. After chemotherapy, the gastric tumor appeared as a small elevated lesion on EGD, and CT revealed a remarkable reduction in the size of the metastatic liver tumors. The patient is still alive, 35 months after the initial chemotherapy.
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.affiliation: Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Emiko
authors.initials: E
authors.lastname: Takahashi
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Manami
authors.initials: M
authors.lastname: Amaike
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Mako
authors.initials: M
authors.lastname: Nohara
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagao
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Ebi
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Funaki
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Kasugai
keywords: Alpha-fetoprotein; Chemotherapy; Gastric cancer; Human epidermal growth factor receptor 2; Protein induced by vitamin K antagonist-II