title: [The comparative study of specificity of test-systems in diagnostic of HIV-infection on categories of samples of blood serum of pregnant women].
abstract: The detection of false positive serological reactions (FPSR) on HIV-infection under screening examination of pregnant women is an actual problem of practical health care. The original observations testify that under analysis of the same samples of blood serum of pregnant women using screening immune enzyme test-systems of various manufacturers the unmatched data concerning FPSR can be obtained. The purpose of this study was to implement comparative evaluation of specificity of immune enzyme test-systems of three different manufacturers: "DS-IFA-HIV-AGAT-SCREEN" ("Diagnostic Systems"), "Genscreen Ultra HIV Ag-Ab" "Bio Rad" France) and "The CombiBest HIV-1,2 AG/AT" ("Vector-Best" Novosibirsk). The sampling of 440 samples of blood serums of pregnant women from various medical institutions of Nizhnii Novgorod was analyzed. The results of the study demonstrated that FPSR were detected in all test-systems and at that spectrum of samples differed. The identical specificity of compared test-systems amounted to 98.64%. The alternative approach to FPSR to HIV issue under screening examinations of pregnant women was proposed. The proposed mode consisted of consistent application of two test-systems of fourth generation with different format of setup of reaction.
authors.forename: I N
authors.initials: IN
authors.lastname: Sharipova
authors.forename: N M
authors.initials: NM
authors.lastname: Khodak
authors.forename: V F
authors.initials: VF
authors.lastname: Puzirev
authors.forename: A N
authors.initials: AN
authors.lastname: Burkov
authors.forename: T I
authors.initials: TI
authors.lastname: Ulanova
mesh_terms: D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D008403:Mass Screening; D011247:Pregnancy; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D012698:Serologic Tests / Q000379:methods*
chemical_list: D011933:Reagent Kits, Diagnostic