title: [Cutaneous manifestations of leukemia].
abstract: BACKGROUND
  To describe the type and frequency of cutaneous manifestations of leukemia.
  
  
  METHODS
  Observational, descriptive study. We included patients over 16 years of age, with confirmed diagnosis of leukemia from the Hematology and Dermatology Departments of the outpatient clinic and from in-patients. Patients with bone marrow transplantation were excluded. A complete history and physical examination of the skin and appendages was performed, with biopsy and cultures if required. The cutaneous manifestations were classified as infection or drug-related, leukemic infiltration, associated dermatosis to leukemia and non-specific lesions. Descriptive statistics was employed.
  
  
  RESULTS
  We included 142 patients (62 females, 80 males) with the following diagnoses: acute myeloid leukemia (n=36), acute lymphoblastic leukemia (n=52), chronic myeloid leukemia (n=21), chronic lymphocitic leukemia (n=30) and hairy cells leukemia (n=3). 42% of patients (n=60) presented some dermatoses. There were 36 non-specific dermatoses, 21 drug-related, 20 infectious, 3 infiltrative and none associated.
  
  
  CONCLUSIONS
  Cutaneous manifestations directly related to leukemia are frequent, being the non-specific ones, the most commonly observed. However, a thorough dermatologic examination is important in these patients as part of an overall evaluation.
authors.affiliation: Departamento de Dermatología, Hospital de Especialidades, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Distrito Federal. dra.npd@hotmail.com.
authors.forename: Nancy
authors.initials: N
authors.lastname: Pulido-Díaz
authors.forename: Gabriela
authors.initials: G
authors.lastname: Medina
authors.forename: Nymrod
authors.initials: N
authors.lastname: Palomino
authors.forename: Fidelio
authors.initials: F
authors.lastname: Peralta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017254:Leukemic Infiltration / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents
keywords: Dermatology; Leukemia; Stem cells