title: Experimental study of antitumour activity and effects on leukocyte count of intraperitoneal administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet in a rat model of ovarian cancer.
abstract: Survival of rats with advanced ovarian cancer after intraperitoneal (i.p.) administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet and effects of these treatment modalities on leukocyte count were evaluated in two independent series of experiments. Hyperthermic intraperitoneal chemoperfusion with dioxadet (15 mg/kg) provided median survival of rats of 49 days (95% CI 28-70), i.p. administration of dioxadet (1.5 mg/kg) of 28 days (95% CI 16-36; P = 0.020). Single i.p. injection of dioxadet caused a significant decrease in total number of leukocytes (17-52%), granulocytes (18-75%), lymphocytes (18-62%) and monocytes (12-46%) in the peripheral blood of tumour-bearing rats compared to untreated animals. After HIPEC with dioxadet, the total number of leukocytes, granulocytes, lymphocytes and monocytes in peripheral blood of rats remained significantly higher than the corresponding values in the group with dioxadet.
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.|b ITMO University , Saint-Petersburg , Russia.
authors.forename: Vladimir Grigorjevich
authors.initials: VG
authors.lastname: Bespalov
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.|b ITMO University , Saint-Petersburg , Russia.
authors.forename: Galina Sergeevna
authors.initials: GS
authors.lastname: Kireeva
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.|b ITMO University , Saint-Petersburg , Russia.
authors.forename: Olesya Alexandrovna
authors.initials: OA
authors.lastname: Belyaeva
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Konstantin Yurjevich
authors.initials: KY
authors.lastname: Senchik
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Alexandr Nikolaevich
authors.initials: AN
authors.lastname: Stukov
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Michail Alexandrovich
authors.initials: MA
authors.lastname: Maydin
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Alexandr Leonidovich
authors.initials: AL
authors.lastname: Semenov
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Georgy Ivanovich
authors.initials: GI
authors.lastname: Gafton
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Konstantin Dzhamiljevich
authors.initials: KD
authors.lastname: Guseynov
authors.affiliation: a N. N. Petrov Research Institute of Oncology of the Russian Ministry of Health , Saint-Petersburg , Russia.
authors.forename: Alexey Mikhailovich
authors.initials: AM
authors.lastname: Belyaev
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D010051:Ovarian Neoplasms / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014227:Triazines / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; C040269:dioxadet
keywords: Dioxadet; Granulocytes; HIPEC; Hyperthermic intraperitoneal chemoperfusion; Leukocytes; Lymphocytes; Monocytes; Ovarian cancer