title: A randomised clinical study to measure the anti-erosion benefits of a stannous-containing sodium fluoride dentifrice.
abstract: BACKGROUND
  To compare the enamel protection efficacy of stannous-containing sodium fluoride and sodium monofluorophosphate (MFP)/triclosan dentifrices marketed in India in an in situ erosion model with acidic challenge.
  
  
  METHODS
  This randomised and controlled, in situ, supervised, double-blind clinical trial employed a two-treatment, four-period crossover design, wherein subjects wore an appliance fitted with human enamel samples 6 h/day during each 10 day treatment period and swished twice daily with their assigned dentifrice slurry: Oral-B(®) Pro-Health (maximum 1,000 ppm F as sodium fluoride with stannous chloride) or Colgate(®) Strong Teeth with Cavity Protection (maximum 1,000 F as sodium MFP and triclosan). Subjects swished with 250 ml of orange juice over a 10 min period after each treatment and twice daily for the acidic erosive challenge. Enamel samples were measured for tooth surface loss using contact profilometry at baseline and day 10.
  
  
  RESULTS
  A total of 34 subjects were randomised to treatment; 32 subjects completed the final visit. Baseline profilometry measurements of the specimen surfaces were near zero within ± 0.3 μm, and no statistically significant difference (P > 0.48) on average was observed between the two test dentifrices. At day 10, the stannous-containing dentifrice demonstrated 88% less erosion (P < 0.0001) relative to the MFP/triclosan dentifrice. Estimated medians (95% confidence intervals) were 0.21 μm (0.17, 0.25) for the stannous-containing dentifrice versus 1.66 μm (1.39, 1.99) for the MFP/triclosan dentifrice. Both dentifrices were well-tolerated.
  
  
  CONCLUSIONS
  Compared with MFP/triclosan toothpaste, a stabilised stannous-containing sodium fluoride dentifrice gave statistically significantly greater protection against tooth enamel surface loss in situ following repeated acid erosive challenge.
authors.affiliation: Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: West
authors.affiliation: Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: Joon
authors.initials: J
authors.lastname: Seong
authors.affiliation: Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Macdonald
authors.affiliation: Procter and Gamble Company, Mason, OH, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: He
authors.affiliation: Procter and Gamble Company, Mason, OH, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Barker
authors.affiliation: Department of Oral and Dental Sciences, University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Hooper
keywords: Dentifrice; erosion; sodium fluoride; stannous fluoride; triclosan