title: A novel C₂₅ sterol peroxide from the endophytic fungus Phoma sp. EA-122.
abstract: A novel C₂₅ sterol peroxide, phomasterol A (1), together with two known compounds (2-3), was isolated from the endophytic fungus Phoma sp. EA-122. The structure of phomasterol A (1) was elucidated by MS, 1D, and 2D NMR data analyses. Phomasterol A (1) was evaluated for its inhibitory activities against protein-tyrosine phosphatases MEG2 and PTP1Bc, showing moderate activities with identical IC₅₀ values of 25 μM.
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Chen
authors.forename: Qiong-Ying
authors.initials: QY
authors.lastname: Fan
authors.forename: He-Ping
authors.initials: HP
authors.lastname: Chen
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000037:antagonists & inhibitors; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010545:Peroxides; D013261:Sterols; C000602058:phomasterol A; C516607:PTPN1 protein, human; C447615:PTPN9 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D054558:Protein Tyrosine Phosphatases, Non-Receptor