title: Towards a biological monitoring guidance value for acrylamide.
abstract: Acrylamide is classified as a potential human carcinogen and neurotoxicant. Biological monitoring is a useful tool for monitoring worker exposure. However, other sources of exposure to acrylamide (including cigarette smoke and diet) also need to be considered. This study has performed repeat measurements of the urinary mercapturic acids of acrylamide (AAMA) and its metabolite glycidamide (GAMA) and determined globin adducts in 20 production-plant workers at a UK acrylamide production facility. The relationship between biomarker levels and environmental monitoring data (air levels and hand washes) was investigated. Good correlations were found between all of the biomarkers (r(2)=0.86-0.91) and moderate correlations were found between the biomarkers and air levels (r(2) = 0.56-0.65). Our data show that urinary AAMA is a reliable biomarker of acrylamide exposure. Occupational hygiene data showed that acrylamide exposure at the company was well within the current UK Workplace Exposure Limit. The 90th percentile of urinary AAMA in non-smoking production-plant workers (537 μmol/mol creatinine (n = 59 samples)) is proposed as a possible biological monitoring guidance value. This 90th percentile increased to 798 μmol/mol if smokers were included (n = 72 samples). These values would be expected following an airborne exposure of less than 0.07 mg/m(3), well below the current UK workplace exposure limit of 0.3mg/m(3). Comparison of biomarker levels in non-occupationally exposed individuals suggests regional variations (between UK and Germany), possibly due to differences in diet.
authors.affiliation: Health & Safety Laboratory, Buxton SK17 9JN, UK. Electronic address: craig.sams@hsl.gsi.gov.uk.
authors.forename: C
authors.initials: C
authors.lastname: Sams
authors.affiliation: Health & Safety Laboratory, Buxton SK17 9JN, UK.
authors.forename: K
authors.initials: K
authors.lastname: Jones
authors.affiliation: Health & Safety Laboratory, Buxton SK17 9JN, UK.
authors.forename: N
authors.initials: N
authors.lastname: Warren
authors.affiliation: Health & Safety Laboratory, Buxton SK17 9JN, UK.
authors.forename: J
authors.initials: J
authors.lastname: Cocker
authors.affiliation: BASF Performance Products Plc, Bradford BD12 OJZ, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bell
authors.affiliation: BASF Performance Products Plc, Bradford BD12 OJZ, UK.
authors.forename: P
authors.initials: P
authors.lastname: Bull
authors.affiliation: BASF Performance Products Plc, Bradford BD12 OJZ, UK.
authors.forename: M
authors.initials: M
authors.lastname: Cain
mesh_terms: D000111:Acetylcysteine / Q000652:urine; D020106:Acrylamide / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D004784:Environmental Monitoring / Q000379:methods*; D004852:Epoxy Compounds / Q000652:urine; D006235:Hand Disinfection; D006801:Humans; D016273:Occupational Exposure / Q000592:standards*; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D004852:Epoxy Compounds; D020106:Acrylamide; C071834:glycidamide; D003404:Creatinine; D000111:Acetylcysteine
keywords: Acrylamide; Biological monitoring; Haemoglobin adduct; Mercapturic acid; Occupational exposure; Urine