title: Dual effect of red wine on liver redox status: a concise and mechanistic review.
abstract: Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotective effects, mainly due to the antioxidant effect of resveratrol, one of its polyphenolic compounds. In this paper, the potential molecular mechanisms through which the protective effects of resveratrol counteract the oxidative effect of ethanol and the way as this dual effect impacts liver oxidative stress are reviewed. Mechanistic evaluation of modulation of oxidative signaling pathways by ethanol and resveratrol may explain the pathogenesis of various liver diseases and ultimately to disclose possible pharmacological therapies.
authors.affiliation: UCIBIO-REQUIMTE, Laboratory of Histology and Embryology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal. psilva@icbas.up.pt.
authors.forename: Paula
authors.identifier: http://orcid.org/0000-0001-7204-6006
authors.initials: P
authors.lastname: Silva
authors.affiliation: UCIBIO-REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
authors.forename: Eduarda
authors.initials: E
authors.lastname: Fernandes
authors.affiliation: UCIBIO-REQUIMTE, Department of Biological Sciences, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira no. 228, 4050-313, Porto, Portugal. felixdc@ff.up.pt.
authors.forename: Félix
authors.initials: F
authors.lastname: Carvalho
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000517:prevention & control*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D059808:Polyphenols / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014920:Wine
chemical_list: D000975:Antioxidants; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol
keywords: Ethanol; Liver; Oxidative stress; Redox signaling; Resveratrol; Wine