title: Brain natriuretic peptide levels variation after left atrial appendage occlusion.
abstract: OBJECTIVE
  To explore the variations of brain natriuretic peptide (BNP) secretion after left atrial appendage occlusion.
  
  
  BACKGROUND
  Left atrial appendage occlusion has been increasingly performed in the last few years, however little is known about the physiological consequences of left atrial appendage occlusion. Left atrial appendage regulates partially intravascular volume via release of brain natriuretic peptide. Brain natriuretic peptide levels have been related to increased risk of stroke in atrial fibrillation patients.
  
  
  METHODS
  Venous blood samples were obtained in consecutive patients undergoing left atrial appendage occlusion before, 24 hr after device implantation and at the first visit after discharge (45-60 days) for BNP measurement.
  
  
  RESULTS
  Left atrial appendage occlusion was performed in 34 patients with non-valvular atrial fibrillation and contraindication to long-term oral anticoagulation or at high-risk of bleeding. There were no differences in BNP levels between baseline and 24 hr after device implantation. However left atrial appendage closure resulted in a significant decrease in BNP levels at the first follow-up visit (45-60 days) compared to baseline measurements (759.90 pg ml(-1) vs. 636.90 pg ml(-1) , P = 0.013).
  
  
  CONCLUSIONS
  Left atrial appendage occlusion modifies BNP levels. These levels decrease after left atrial appendage occlusion. The clinical consequences of these findings need to be evaluated in further studies. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Cruz-Gonzalez
authors.affiliation: Cardiology Department, Gomez Ulla Hospital, Madrid, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Palazuelos Molinero
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Maria
authors.initials: M
authors.lastname: Valenzuela
authors.affiliation: Cardiology Department, Gomez Ulla Hospital, Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rada
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Jose Angel
authors.initials: JA
authors.lastname: Perez-Rivera
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Antonio
authors.initials: A
authors.lastname: Arribas Jimenez
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Tania
authors.initials: T
authors.lastname: Gabella
authors.affiliation: Gastroenterology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Ana Beatriz
authors.initials: AB
authors.lastname: Prieto
authors.affiliation: Neurology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Jorge
authors.initials: J
authors.lastname: Martín Polo
authors.affiliation: Cardiology Department, University Hospital of Salamanca, IBSAL, Salamanca, Espana.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Sánchez
mesh_terms: D000368:Aged; D020517:Atrial Appendage / Q000000981:diagnostic imaging / Q000601:surgery*; D001281:Atrial Fibrillation / Q000097:blood / Q000150:complications / Q000601:surgery*; D006328:Cardiac Catheterization / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000295:instrumentation*; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D055989:Septal Occluder Device; D013030:Spain / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D015996:Survival Rate / Q000639:trends
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: brain natriuretic peptide; left atrial appendage