title: [Health evaluation of indoor air carcinogens: first addendum to the basic scheme. Communication from the German Committee on Indoor Guidelines].
abstract: According to the German Committee on Indoor Guidelines valid data on the usual occurrence of a carcinogenic substance in indoor air (e. g. the 95(th) percentile or reference value) and its exposure-risk relationship must be available for health evaluation. Depending on the mechanism of action of the substance the Committee decides which dose-response relationship is appropriate.Given a valid exposure-risk relationship the concentration of an indoor air carcinogen associated with a theoretical cancer risk of 10(-6) following lifetime exposure has to be estimated. The obtained concentration has to be compared to its reference value.If the concentration obtained from the exposure-risk relationship exceeds the reference value, it will be used as a risk-related guideline. If the concentration of the reference value is associated with a cancer risk above 10(-6), the reference value will be used as preliminary guideline.
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis*; D002273:Carcinogens / Q000032:analysis*; D004777:Environment; D004784:Environmental Monitoring / Q000592:standards*; D005858:Germany; D033161:Government Regulation; D017410:Practice Guidelines as Topic; D014241:Trichloroethylene / Q000032:analysis*
chemical_list: D002273:Carcinogens; D014241:Trichloroethylene