title: Genetic Variants Associated With Atrial Fibrillation and PR Interval Following Cardiac Surgery.
abstract: OBJECTIVE
  The authors hypothesized that genetic association between atrial fibrillation (AF)-associated and PR-associated genetic loci was biologically mediated through slower conduction velocities for some or all of these loci.
  
  
  METHODS
  Prospectively collected cohort study.
  
  
  METHODS
  Single tertiary care university hospital.
  
  
  METHODS
  A total of 1227 Caucasian patients who underwent coronary artery bypass grafting (CABG).
  
  
  METHODS
  A total of 677 single nucleotide polymorphisms previously associated with ambulatory AF or PR interval were tested for association with postoperative atrial fibrillation (poAF) and preoperative PR interval, maximum PR interval, maximum change in PR interval, and maximum change in PR interval from preoperative PR interval.
  
  
  RESULTS
  The incidence of new-onset poAF was 31%. All of the PR interval variables were longer in the poAF cohort. Two variants on 1q21 and 12 on 4q25 were associated with poAF after adjustment for false discovery rate (FDR), but no variants were associated with PR interval variables after adjustment for FDR. Several variants were associated with both poAF and PR interval variables at p<0.05, but none of them remained significant after adjusting for FDR.
  
  
  CONCLUSIONS
  It was found that patients with poAF have significantly longer PR interval. Genetic variants in both the 1q21 and 4q25 regions associate with poAF after CABG surgery, but the authors were unable to find association between these variants and PR interval after adjusting for FDR.
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: msigurdsson@partners.org.
authors.forename: Martin I
authors.initials: MI
authors.lastname: Sigurdsson
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Jochen D
authors.initials: JD
authors.lastname: Muehlschlegel
authors.affiliation: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Fox
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Mahyar
authors.initials: M
authors.lastname: Heydarpour
authors.affiliation: Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.affiliation: Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.affiliation: Division of Cardiovascular Anesthesia, Texas Heart Institute, St. Luke's Hospital, Houston, Texas.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Collard
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Stanton K
authors.initials: SK
authors.lastname: Shernan
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Simon C
authors.initials: SC
authors.lastname: Body
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D015331:Cohort Studies; D004562:Electrocardiography / Q000379:methods; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D011446:Prospective Studies
keywords: 1q21; 4q25; PR interval; atrial fibrillation; cardiac surgery; genomics