title: Microtubule-depolymerizing kinesins in the regulation of assembly, disassembly, and length of cilia and flagella.
abstract: Defects in ciliary assembly, maintenance, and signaling are associated with various human diseases and developmental disorders, termed ciliopathies. Eukaryotic flagella and cilia (interchangeable terms) are microtubule-based organelles. Thus, microtubule dynamics and microtubule-dependent transport are predicted to affect the structural integrity and functionality of cilia profoundly. Kinesin-2 is well known for its role in intraflagellar transport to transport ciliary precursors and signaling molecules. Recently, microtubule-depolymerizing kinesins found in kinesin-8, -13, and -14A families have emerged as regulators of cilia. We first discuss ciliary kinesins identified in the flagellar or ciliary proteome, and then focus on the function and regulation of microtubule-depolymerizing kinesins. Lastly, we review the recent advances of microtubule-depolymerizing kinesins in controlling ciliary assembly, disassembly, and length.
authors.affiliation: MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Zhangfeng
authors.initials: Z
authors.lastname: Hu
authors.affiliation: MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Yinwen
authors.initials: Y
authors.lastname: Liang
authors.affiliation: MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Meng
authors.affiliation: School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of Protein Science, School of Life Sciences, Tsinghua University, Beijing, China.
authors.forename: Junmin
authors.initials: J
authors.lastname: Pan
mesh_terms: D000818:Animals; D001692:Biological Transport; D002923:Cilia / Q000502:physiology*; D005407:Flagella / Q000502:physiology*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D008870:Microtubules / Q000502:physiology*
chemical_list: D016547:Kinesins
keywords: Cilia and flagella; Depolymerizing kinesin; Flagellar assembly; Flagellar disassembly; Flagellar length control; Microtubule