title: Changed Serum Cytokine Profile in Mice in Response to Streptococcus A Culture.
abstract: Comparative analysis of serum cytokine profiles of CBA mice was carried out 1, 5, 24, and 48 h after intraperitoneal injection of killed culture of different streptococcus A types. The production of cytokines in response to different streptococcus types varied. The highest level was recorded in response to types 1M and 3T+M, more often detected in invasive streptococcal infection. The highest levels of IL-2 were recorded in response to 1M (47-fold increase in comparison with the control) and 3T+M streptococcus types (more than 10-fold increase). Injections of these types also led to an increase of IFN-γ level (15.6 and 11.3 times, respectively). The level of TNF-α increased less (3.6 times in response to 3T+M and 2.6 times in response to 1M type). The levels of IL-5, IL-10, and IL-12 increased 2-3-fold. Injections of 1T and 5M types led to just a 2-fold increase of cytokine levels. These data indicated induction of the immune response trend by mainly Th1 or mixed Th1/Th2 pattern in response to group A streptococcus antigens.
authors.affiliation: Laboratory of Microbiology of Latent Infections, Moscow, Russia, dansen@inbox.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Danilova
authors.forename: A A
authors.initials: AA
authors.lastname: Adzhieva
authors.forename: G A
authors.initials: GA
authors.lastname: Danilina
authors.forename: V G
authors.initials: VG
authors.lastname: Lunin
authors.forename: V I
authors.initials: VI
authors.lastname: Grabko
authors.forename: A G
authors.initials: AG
authors.lastname: Minko
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D000939:Epitopes / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000378:metabolism; D007249:Inflammation; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000097:blood / Q000378:metabolism; D007378:Interleukins / Q000097:blood / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D018716:Molecular Mimicry; D009206:Myocardium / Q000276:immunology; D065288:Serogroup; D013297:Streptococcus pyogenes / Q000145:classification / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D016207:Cytokines; D000939:Epitopes; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; C014689:streptococcal M protein; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor