title: A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids.
abstract: A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.
authors.affiliation: School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. s.p.marsden@leeds.ac.uk a.s.nelson@leeds.ac.uk.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Foley
authors.forename: Richard G
authors.initials: RG
authors.lastname: Doveston
authors.forename: Ian
authors.initials: I
authors.lastname: Churcher
authors.forename: Adam
authors.initials: A
authors.lastname: Nelson
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Marsden
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000596:Amino Acids; D053961:Azabicyclo Compounds; D001381:Azepines; D011725:Pyridines