title: [Dermo-hypodermitis caused by group B Streptococcus in infants under 3 months of age: A retrospective study in two hospitals].
abstract: BACKGROUND
  Very few studies describe group B streptococcal dermo-hypodermitis in newborns.
  
  
  OBJECTIVE
  To describe the incidence, clinical characteristics, and course of group B streptococcal dermo-hypodermitis in infants less than 3 months old.
  
  
  METHODS
  Infants under 3 months of age, hospitalized for group B streptococcal dermo-hypodermitis at Robert Debré University Hospital, Paris, France, and at Orsay Hospital, Orsay, France, between January 2002 and August 2013, were included in a retrospective study.
  
  
  RESULTS
  Five infants were included in this study. All the infections occurred late. Dermo-hypodermitis accounted for 7% of the overall late-onset group B streptococcal infections during the same period. Four patients were male and had a risk factor of maternal-fetal infection (prematurity/hypotrophy). Four patients had specific clinical signs of dermo-hypodermitis with septic shock features on admission. One patient had meningitis and associated parotitis. Group B Streptococcus was isolated from blood culture of all patients. Serotype III Streptococcus was identified in four cases. The duration of intravenous antibiotic therapy varied from 7 to 23 days and the total duration of antibiotic therapy was between 14 and 44 days. The progression was favorable for all the infants, with no recurrence.
  
  
  CONCLUSIONS
  Dermo-hypodermitis in infants under 3 months of age is rare but could be an early indicator of group B streptococcal bacteremia and/or sepsis. Early diagnosis of this severe complication and appropriate antibiotic therapy are critical.
authors.affiliation: Service des urgences pédiatriques, hôpital Necker-Enfants-Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France. Electronic address: anne-laure.tarbe-de-saint-hardouin@nck.aphp.fr.
authors.forename: A-L
authors.initials: AL
authors.lastname: Tarbé de Saint Hardouin
authors.affiliation: Laboratoire de microbiologie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.affiliation: Laboratoire de biologie clinique, centre hospitalier d'Orsay, 4, place du Général-Leclerc, 91401 Orsay, France.
authors.forename: V
authors.initials: V
authors.lastname: Esteve
authors.affiliation: Service de pédiatrie générale et de néonatologie, centre hospitalier d'Orsay, 4, place du Général-Leclerc, 91401 Orsay, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Msélati
authors.affiliation: Inserm UMR 1123, service de pédiatrie générale, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Université Paris Diderot, sorbonne Paris Cité, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lorrot
authors.affiliation: Département de l'information médicale, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Blachier
authors.affiliation: Université Paris Diderot, sorbonne Paris Cité, Paris, France; Service de néonatologie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
authors.affiliation: Laboratoire de microbiologie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Université Paris Diderot, sorbonne Paris Cité, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bonacorsi
authors.affiliation: Inserm UMR 1123, service de pédiatrie générale, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France; Université Paris Diderot, sorbonne Paris Cité, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Faye
mesh_terms: D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D017192:Skin Diseases, Bacterial / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D013290:Streptococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D013292:Streptococcus agalactiae