title: Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging.
abstract: Core-shell upconversion nanoparticle@metal-organic framework (UCNP@MOF) nanostructures are constructed by coating hexagonal NaYF4 :Yb,Er nanoparticle (NP) cores with amino-functionalized iron carboxylate MOF shells. These nanostructures combine the near-infrared optical property of the UCNP cores and the T2 -magnetic response (MR) imaging property of the MOF shells. After surface modification, the core-shell nanostructures are demonstrated as high-resolution nanoprobes for targeted luminescence/MR imaging both in vitro and in vivo.
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Yantao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Jinglong
authors.initials: J
authors.lastname: Tang
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Liangcan
authors.initials: L
authors.lastname: He
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.affiliation: Key Laboratory of Nanosystem and Hierarchical Fabrication, Chinese Academy of Sciences, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Tang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D049449:Luminescence; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D009368:Neoplasm Transplantation; D011092:Polyethylene Glycols / Q000737:chemistry; D013057:Spectrum Analysis; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D058185:Magnetite Nanoparticles; D014867:Water; D011092:Polyethylene Glycols
keywords: biocompatibility; core-shell nanostructures; dual-mode targeted imaging; surface modification