title: [Inflammation and obesity (lipoinflammation)].
abstract: Obesity is a chronic disease with multiple origins. It is a widespread global phenomenon carrying potentially serious complications which requires a multidisciplinary approach due to the significant clinical repercussions and elevated health costs associated with the disease. The most recent evidence indicates that it shares a common characteristic with other prevalent, difficult-to-treat pathologies: chronic, low-grade inflammation which perpetuates the disease and is associated with multiple complications. The current interest in lipoinflammation or chronic inflammation associated with obesity derives from an understanding of the alterations and remodelling that occurs in the adipose tissue, with the participation of multiple factors and elements throughout the process. Recent research highlights the importance of some of these molecules, called pro-resolving mediators, as possible therapeutic targets in the treatment of obesity. This article reviews the evidence published on the mechanisms that regulate the adipose tissue remodelling process and lipoinflammation both in obesity and in the mediators that are directly involved in the appearance and resolution of the inflammatory process.
authors.affiliation: Centro de Investigación de Endocrinología y Nutrición Clínica. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valladolid. Universidad de Valladolid (Valladolid), España.. olatzizaola@yahoo.es.
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Centro de Investigación de Endocrinología y Nutrición Clínica. Servicio de Endocrinología y Nutrición. Hospital Clínico Universitario de Valladolid. Universidad de Valladolid (Valladolid), España.. olatzizaola@yahoo.es.
authors.forename: Daniel
authors.initials: D
authors.lastname: de Luis
authors.affiliation: Director Médico de PronoKal Group (Barcelona), España.. olatzizaola@yahoo.es.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Sajoux
authors.affiliation: Departamento de Bioquímica y Biología Molecular. Facultad de Biología. Universidad de Barcelona (Barcelona), España.. olatzizaola@yahoo.es.
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Domingo
authors.affiliation: Directora área científica. CROSSDATA-Punta Alta Comunicación (Barcelona), España.. olatzizaola@yahoo.es.
authors.forename: Montse
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D016207:Cytokines