title: Neurodevelopmental evaluation of children with cyanotic congenital heart disease.
abstract: BACKGROUND
  The aim of the study was to perform a neurodevelopmental evaluation of the children with cyanotic congenital heart disease and to determine the factors that affect the neurodevelopmental status.
  
  
  METHODS
  The study was performed in the Pediatric Cardiology Department of Behcet Uz Children's Hospital between February and August 2013. Children between the age of six to forty-two months were included in the study and were evaluated in three groups (two patient groups and the control group). In group A, patients with isolated cyanotic congenital heart disease were enrolled. Group B consisted of the patients with cyanotic congenital heart disease with other concomitant diseases. Group C included the healthy control group. For the neurodevelopmental evaluation Bayley Scale of Infant Development- II (BSID-II) was used. Mental Developmental Index (MDI) and Psychmotor Developmental Index (PDI) scores were calculated. Factors possibly effective on neurodevelopment were evaluated.
  
  
  RESULTS
  Thirty eight patients (32 in group A and 6 in group B) and 33 healthy subjects in group C were included in the study. Mean age of the patient group was 22.5±11.2 months. In group A mean MDI Score (82.5±14.7) was significantly lower than group C (92.3±6.9) (P=0.001). Similarly mean PDI Score in group A (82.0±18.2) was found significantly lower than group C (92.5±7.4) (P=0.003). When group A and B were compared, mean MDI and PDI scores were lower in group B, but the difference was not statistically significant. For group A, according to the psychomotor development index, 41.6% of the patients were found to be mildly to severely retarded. In terms of the mental development index, 34.4% of the patients had moderate or mild retardation. The sex, socioeconomic status, gestational age, birth weight, comorbidities, history of surgery and reoperation, length of stay in intensive care unit were not found influential on the MDI and PDI scores of the patients.
  
  
  CONCLUSIONS
  Mental-motor retardation is frequently encountered in children with cyanotic congenital heart disease. These patients may benefit from motor, language, speech, developmental and educational therapies. For this reason, these children have to be under regular follow up for neurodevelopmental status.
authors.affiliation: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: İlksen Z
authors.initials: İZ
authors.lastname: Yilmaz
authors.affiliation: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey - bariserdur@yahoo.com.
authors.forename: Baris
authors.initials: B
authors.lastname: Erdur
authors.affiliation: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Ozbek
authors.affiliation: Department of Pediatric Cardiology, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Timur
authors.initials: T
authors.lastname: Mese
authors.affiliation: Department of Pediatrics, Dokuz Eylul University, School of Medicine, Izmir, Turkey.
authors.forename: Utku
authors.initials: U
authors.lastname: Karaarslan
authors.affiliation: Department of Pediatrics, Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Genel
mesh_terms: D016022:Case-Control Studies; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003490:Cyanosis / Q000150:complications / Q000151:congenital*; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey