title: The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats.
abstract: The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemia was achieved by abdominal aorta clamping, and all animals were sacrificed 24 h after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Ischemic fiber degeneration significantly reduced in the SNI + CA and SNI + MP groups, especially in the SNI + MP group, compared to the SNI group (p < 0.05). Beta amyloid protein expressions were significantly decreased in the SNI + CA group compared to the SNI group (p < 0.05). Our study revealed that coumaric acid treatment after ischemia/reperfusion in rat sciatic nerves reduced oxidative stress and axonal degeneration. Therefore, coumaric acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey. drmustafaguven@comu.edu.tr.
authors.forename: Mustafa
authors.identifier: http://orcid.org/0000-0001-8643-9775
authors.initials: M
authors.lastname: Guven
authors.affiliation: Department of Histology & Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Yuksel
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Muserref Hilal
authors.initials: MH
authors.lastname: Sehitoglu
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Medipol University, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tokmak
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Adem Bozkurt
authors.initials: AB
authors.lastname: Aras
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Tarik
authors.initials: T
authors.lastname: Akman
authors.affiliation: Department of Orthopaedic, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Umut Hatay
authors.initials: UH
authors.lastname: Golge
authors.affiliation: Department of Orthopaedic, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Ferdi
authors.initials: F
authors.lastname: Goksel
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.
authors.forename: Ergun
authors.initials: E
authors.lastname: Karavelioglu
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Cosar
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003373:Coumaric Acids / Q000494:pharmacology*; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008775:Methylprednisolone / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051266:Nuclear Respiratory Factor 1 / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D059348:Peripheral Nerve Injuries / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020426:Sciatic Neuropathy / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D003373:Coumaric Acids; D005938:Glucocorticoids; D018696:Neuroprotective Agents; D051266:Nuclear Respiratory Factor 1; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D008775:Methylprednisolone
keywords: coumaric acids; malondialdehyde; methylprednisolone; nuclear respiratory factor 1; reperfusion injury; sciatic nerve; superoxide dismutase