title: Will Women Diagnosed with Breast Cancer Provide Biological Samples for Research Purposes?
abstract: BACKGROUND
  Little is known about the response rates for biological sample donation and attitudes towards control recruitment, especially in younger women. The goals of this pilot study were to determine in women recently diagnosed with breast cancer, the proportion of cases willing to provide biological samples and for purposes of control recruitment, contact information for friends or colleagues.
  
  
  METHODS
  A population-based sample of breast cancer cases (n = 417, 25-74 years) was recruited from the Ontario Cancer Registry in 2010 and self-administered questionnaires were completed to determine willingness to provide samples (spot or 24-hr urine, saliva, blood) and contact information for friends/colleagues for control recruitment. Using Χ2 analyses of contingency tables we evaluated if these proportions varied by age group (<45 and 45+) and other factors such as ethnicity, education, income, body mass index (BMI), smoking status and alcohol consumption.
  
  
  RESULTS
  Cases were willing to provide blood samples, by visiting a clinic (62%) or by having a nurse visit the home (61%). Moreover, they would provide saliva (73%), and morning or 24-hr urine samples (66% and 52%). Younger cases (≤45) were 3 times (OR) more likely more than older cases to agree to collect morning urine (95% CI: 1.15-8.35). Only 26% of cases indicated they would provide contact information of friends or work colleagues to act as controls. Educated cases were more likely to agree to provide samples, and cases who consumed alcohol were more willing to provide contact information. Ethnicity, income, BMI and smoking had little effect on response rates.
  
  
  CONCLUSIONS
  Reasonable response rates for biological sample collection should be expected in future case controls studies in younger women, but other methods of control selection must be devised.
authors.affiliation: Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada; Occupational Cancer Research Centre, Toronto, Ontario, M5G 1X3, Canada.
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Harris
authors.affiliation: Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada; Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, M5S 3E2, Canada.
authors.forename: Beatrice A
authors.initials: BA
authors.lastname: Boucher
authors.affiliation: Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Cotterchio
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001290:Attitude; D018070:Biological Specimen Banks; D001943:Breast Neoplasms / Q000473:pathology* / Q000523:psychology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D018579:Patient Selection; D010865:Pilot Projects; D013048:Specimen Handling / Q000379:methods / Q000523:psychology*; D011795:Surveys and Questionnaires