title: Evaluation of Vitamin D Status in Newly Diagnosed Pemphigus Vulgaris Patients.
abstract: BACKGROUND
  Pemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin or mucosa. Since low vitamin D status has been linked to many immune disorders, we designed this study to compare the vitamin D status in PV patients with healthy controls.
  
  
  METHODS
  In this case-control study, vitamin D status of 32 newly diagnosed PV patients was compared with 36 healthy control subjects. All patients were selected from the specialized dermatology departments of Razi Hospital, Tehran University of Medical Sciences in a 2-year period (2009-2010). The severity of the disease was estimated according to Harman's scores. Serum concentration of 25(OH)D was measured by Roche Elecsys System. Data were analyzed by independent t-test.
  
  
  RESULTS
  Both groups were similar based on sex, age and body mass index. The mean duration of disease was 5.57±0.93 months. The mean oral and skin severities were 1.81±0.20 and 2.31±0.17 respectively, based on Harman's scores. Serum 25(OH)D was significantly lower in PV patients compared to controls (-8.90; 95% CI, 2.29-15.51 and P = 0.009). There was a negative correlation between vitamin D level and the oral severity of disease (r = -0.39 and P = 0.02).
  
  
  CONCLUSIONS
  PV patients had significantly lower serum level of 25(OH)D compared to healthy subjects which might contribute to worsen the disease. These data indicate the importance of improving vitamin D level in pemphigus patients.
authors.affiliation: 1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Zarei
authors.affiliation: 1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mohammad Hassan
authors.initials: MH
authors.lastname: Javanbakht
authors.affiliation: 2. Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Cheida
authors.initials: C
authors.lastname: Chams-Davatchi
authors.affiliation: 2. Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Daneshpazhooh
authors.affiliation: 3. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.affiliation: 1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Hoda
authors.initials: H
authors.lastname: DE-Rakhshanian
authors.affiliation: 1. Dept. of Cellular and Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Djalali
keywords: Calcitriol; Pemphigus vulgaris; Vitamin D