title: Two approaches to the model drug immobilization into conjugated polymer matrix.
abstract: The purpose of this study is to develop biocompatible and conducting coating being carrier of biologically active compounds with the potential use in neuroprosthetics. Conducting polypyrrole matrix has been used to immobilize and release model drugs, quercetin and ciprofloxacin. Two routes of immobilization are described: drugs have been incorporated in the polymer matrix in the course of the electropolymerization process or after polymerization, in the course of polymer oxidation. Using UV/Vis spectroscopic detection we demonstrate that both immobilization approaches display different drug-loading efficiencies. In the case of ciprofloxacin, drug incorporation following synthesis is a more efficient immobilization approach (final drug concentration: 43.3 (±9.5) μM/cm(2)), while for quercetin the highest loading is accomplished by drug incorporation during synthesis (final drug concentration: 29.1 (±5.9) μM/cm(2)). The process of drug incorporation results in the variation of surface morphology with respect to the method of immobilization as well as the choice of drug. The results prove that electrochemical methods are efficient procedures for making multifunctional polymer matrices which might be perspective bioactive coatings for implantable neuroprosthetic devices.
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M.Strzody 9, 44-100 Gliwice, Poland. Electronic address: katarzyna.krukiewicz@polsl.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krukiewicz
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M.Strzody 9, 44-100 Gliwice, Poland. Electronic address: anna.stokfisz@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Stokfisz
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M.Strzody 9, 44-100 Gliwice, Poland. Electronic address: jerzy.zak@polsl.pl.
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Zak
mesh_terms: D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D002939:Ciprofloxacin; D011794:Quercetin
keywords: Ciprofloxacin; Conjugated polymers; Controlled release; Drug immobilization; Polypyrrole; Quercetin