title: Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
abstract: In recent issues of Molecular Cell, two reports identify that K63-linked RagA polyubiquitination and subsequent recruitment of GATOR1, a complex with GAP activity toward RagA/B GTPases, can attenuate amino acid-induced mTORC1 signaling.
authors.affiliation: Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. Electronic address: dfingar@umich.edu.
authors.forename: Diane C
authors.initials: DC
authors.lastname: Fingar
mesh_terms: D000818:Animals; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D046912:Multiprotein Complexes; D044767:Ubiquitin-Protein Ligases; D058570:TOR Serine-Threonine Kinases; D020559:Monomeric GTP-Binding Proteins