title: Mercury Exposure and Endothelial Dysfunction: An Interplay Between Nitric Oxide and Oxidative Stress.
abstract: Vascular endothelium plays a vital role in the organization and function of the blood vessel and maintains homeostasis of the circulatory system and normal arterial function. Functional disruption of the endothelium is recognized as the beginning event that triggers the development of consequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. There is a growing data associating mercury exposure with endothelial dysfunction and higher risk of CVD. This review explores and evaluates the impact of mercury exposure on CVD and endothelial function, highlighting the interplay of nitric oxide and oxidative stress.
authors.affiliation: School of Sciences, Indira Gandhi National Open University, New Delhi, India swatiomanwar@gmail.com.
authors.forename: Swati
authors.initials: S
authors.lastname: Omanwar
authors.affiliation: Hamdard Institute of Medical Science and Research, Hamdard University, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Fahim
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000473:pathology*; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008628:Mercury / Q000633:toxicity*; D009569:Nitric Oxide / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D009569:Nitric Oxide; D008628:Mercury
keywords: NO; cardiovascular disease; endothelium; mercury; oxidative stress