title: Protective effects of polyethylene oxide on the vascular and organ function of rats with severe hemorrhagic shock.
abstract: This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock. The shocked rats were resuscitated with either Ringer's lactate solution or 20 ppm of PEO in Ringer's lactate solution for 1 h. It was found that infusion of PEO effectively improved the survival, metabolic acidosis, oxygen delivery, hyperlactacidemia, tissue perfusion, and inflammatory responses of rats subjected to hemorrhagic shock. In addition, we found, for the first time, that PEO showed protective effects on hepatic and renal injury, as evidenced by the significant decreases in the elevated levels of alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine caused by shock induction after infusion of PEO (p < 0.05, 60 min post-resuscitation by comparison with pre-resuscitation). All of these findings indicate that PEO exhibits strong therapeutic effects under conditions of severe hemorrhagic shock,which also provides theoretical and experimental bases for the clinical use of PEO.
authors.affiliation: Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.|Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.|Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.|Department of Kidney Transplantation, the Affiliated Hospital of Qingdao University, 1677 Wutaishan Road, Qingdao 266000, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects; D018836:Inflammation Mediators / Q000097:blood; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D017093:Liver Failure / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D020011:Protective Agents / Q000008:administration & dosage*; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D000077325:Ringer's Lactate; D012720:Severity of Illness Index; D012771:Shock, Hemorrhagic / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D007552:Isotonic Solutions; D020011:Protective Agents; D000077325:Ringer's Lactate; D019344:Lactic Acid; D011092:Polyethylene Glycols
keywords: choc hémorragique; drag-reducing polymers; hemorrhagic shock; lésion organique; microcirculation; organ damage; polyethylene oxide; polymères réducteurs de frottement; polyéthylène glycol; survival rate; taux de survie