title: Zebrafish as a Model for the Study of Human Myeloid Malignancies.
abstract: Myeloid malignancies are heterogeneous disorders characterized by uncontrolled proliferation or/and blockage of differentiation of myeloid progenitor cells. Although a substantial number of gene alterations have been identified, the mechanism by which these abnormalities interact has yet to be elucidated. Over the past decades, zebrafish have become an important model organism, especially in biomedical research. Several zebrafish models have been developed to recapitulate the characteristics of specific myeloid malignancies that provide novel insight into the pathogenesis of these diseases and allow the evaluation of novel small molecule drugs. This report will focus on illustrative examples of applications of zebrafish models, including transgenesis, zebrafish xenograft models, and cell transplantation approaches, to the study of human myeloid malignancies.
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan.
authors.forename: Jeng-Wei
authors.initials: JW
authors.lastname: Lu
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan.
authors.forename: Meng-Shan
authors.initials: MS
authors.lastname: Hsieh
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan.
authors.forename: Heng-An
authors.initials: HA
authors.lastname: Liao
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Institute of Preventive Medicine, National Defense Medical Center, No. 172 Dapu Road, New Taipei City 237, Taiwan ; Graduate Institute of Life Sciences, National Defense Medical Center, No. 161, Section 6, Minquan East Road, Taipei 114, Taiwan.
authors.forename: Yi-Jung
authors.initials: YJ
authors.lastname: Ho
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, No. 1 Chang-Te Street, Taipei 100, Taiwan ; Department of Laboratory Medicine, National Taiwan University Hospital, No. 7 Chung-Shan Southern Road, Taipei 100, Taiwan.
authors.forename: Liang-In
authors.initials: LI
authors.lastname: Lin
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D023041:Xenograft Model Antitumor Assays; D015027:Zebrafish / Q000235:genetics*