title: [Automated measurement of biomarkers for the diagnosis of acute myocardial infarction].
abstract: BACKGROUND
  Cardiac biomarkers have a prominent role in the diagnosis of acute myocardial infarction.
  
  
  OBJECTIVE
  The aim of the authors was to study the diagnostic effectiveness of automated measurement of cardiac biomarkers.
  
  
  METHODS
  Myeloperoxidase, high-sensitivity C-reactive protein, myoglobin, heart-type fatty acid binding protein, creatine kinase, creatine kinase MB, high-sensitivity troponin I and T were measured.
  
  
  RESULTS
  The high-sensitivity troponin I was the most effective (area under curve: 0.86; 95% confidence interval: 0.77-0.95; p<0.001) for the diagnosis of acute myocardial infarction. Considering a critical value of 0.35 ng/mL, its sensitivity and specificity were 81%, and 74%, respectively. Combined evaluation of the high-sensitivity troponin T and I, chest pain, and the electrocardiogram gave the best results for separation of acute myocardial infarction from other diseases (correct classification in 62.5% and 98.9% of patients, respectively).
  
  
  CONCLUSIONS
  Until a more sensitive and specific cardiac biomarker becomes available, the best method for the diagnosis of acute myocardial infarction is to evaluate electrocardiogram and biomarker concentration and to repeat them after 3-6 hours.
authors.affiliation: Központi Laboratórium, Kanizsai Dorottya Kórház Nagykanizsa, Szekeres u. 2-8., 8800.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Kovács
authors.forename: Ibolya
authors.initials: I
authors.lastname: Kocsis
authors.forename: Marina
authors.initials: M
authors.lastname: Varga
authors.forename: Enikő
authors.initials: E
authors.lastname: Sárváry
authors.forename: György
authors.initials: G
authors.lastname: Bicsák
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000209:etiology*; D057205:Automation, Laboratory; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002637:Chest Pain / Q000209:etiology; D008078:Cholesterol, LDL / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood; D003937:Diagnosis, Differential; D004562:Electrocardiography; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D009211:Myoglobin / Q000097:blood; D009195:Peroxidase / Q000097:blood; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013997:Time Factors; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D009211:Myoglobin; D019210:Troponin I; D020107:Troponin T; D002097:C-Reactive Protein; D009195:Peroxidase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form
keywords: acute myocardial infarction; akut myocardialis infarctus; cardiac biomarkers; szívbiomarkerek