title: Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine.
abstract: The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more potent than for prophylactic vaccines. Here, we report that compared to conventional alum adjuvant, aluminum oxide nanoparticles (nano-alum) may further enhance the anticancer effects of an immunotherapy that employs tumor cell vaccine (TCV). The average tumor size tends to be lower in animals that receive the combinational treatment of nano-alum and TCV. The anticancer cytotoxicity by the lymphocytes was also significantly higher in the treatment group that received both TCV and nano-alum. These results suggest that nano-alum may potentially serve as a potent immune adjuvant and have prospective applications in anticancer immunotherapy.
authors.affiliation: Peking Union Medical College Hospital, Beijing, 100730 China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Center of Nanoscience and Technology, Beijing, 100080 China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Duan
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Jin
authors.initials: J
authors.lastname: Ma
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Jiayan
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Institute of Physics, Chinese Academy of Sciences, Beijing, 100080 China.
authors.forename: Sishen
authors.initials: S
authors.lastname: Xie
authors.affiliation: Peking Union Medical College Hospital, Beijing, 100730 China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Peking Union Medical College Hospital, Beijing, 100730 China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Peking Union Medical College Hospital, Beijing, 100730 China.
authors.forename: Shuchang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Beijing TianTan Hospital, Beijing, 100050 China.
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Xu
authors.affiliation: National Center of Nanoscience and Technology, Beijing, 100080 China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005 China.
authors.forename: Xian-Da
authors.initials: XD
authors.lastname: Yang
keywords: Aluminum; Anticancer; Immune adjuvant; Nanoparticle