title: Prostate cancer stroma: an important factor in cancer growth and progression.
abstract: Reactive stromal changes that occur in different human cancers might play a role in local tumor spreading and progression. Studies done on various human cancers have shown activated stromal cell phenotypes, modified extracellular matrix (ECM) composition, and increased microvessel density. Furthermore, they exhibit biological markers consistent with stroma at the site of wound repair. In prostate cancer, stroma is composed of fibroblasts, myofibroblasts, endothelial cells and immune cells. Predominant cells in the tumorous stroma are, however, fibroblasts/ myofibroblasts. They are responsible for the synthesis, deposition and remodeling of the ECM. Epithelial tumorous cells, in interaction with stromal cells and with the help of various molecules of ECM, create a microenvironment suitable for cancer cell proliferation, movement, and differentiation. In this review, we discussed the role of different stromal components in prostate cancer as well as their potential prognostic and therapeutic significance.
authors.affiliation: Department of pathology, Sestre milosrdnice University Hospital, Zagreb. bozo.kruslin@kbcsm.hr.
authors.forename: Božo
authors.initials: B
authors.lastname: Krušlin
authors.forename: Monika
authors.initials: M
authors.lastname: Ulamec
authors.forename: Davor
authors.initials: D
authors.lastname: Tomas
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D005109:Extracellular Matrix / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D055806:Microvessels / Q000473:pathology; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000473:pathology*; D051381:Rats; D017154:Stromal Cells / Q000473:pathology*