title: Health-related quality of life may deteriorate from adolescence to young adulthood after extremely preterm birth.
abstract: OBJECTIVE
  This study examined the development of health-related quality of life (HRQoL) and health from adolescence to adulthood after extremely preterm birth.
  
  
  METHODS
  We assessed a population-based cohort of extremely preterm-born (EPB) infants (gestational age of ≤28 weeks or birthweight of ≤1000 grams) and term-born (TB) controls at 17 and 24 years of age. They completed the Child Health Questionnaire-Child Form 87 at 17 years of age, the Short Form Health Survey-36 (SF-36) at 24 years of age and the Health Behaviour in School-aged Children-Symptom Checklist at both ages.
  
  
  RESULTS
  Of the 51 eligible EPB subjects, 46 (90%) were included and nine had severe neurosensory disabilities. On the whole, EPB and TB subjects gave their HRQoL and health similar ratings, but EPB subjects with disabilities reported poorer physical functioning at 17 and EPB subjects without disabilities reported lower scores on three of the eight SF-36 scales for social functioning and mental health and reported more psychological health complaints at 24. Differences remained in adjusted analyses. Changes from 17 to 24 years of age were minor in EPB subjects with disabilities.
  
  
  CONCLUSIONS
  Our comparison of EPB and TB subjects at the ages of 17 and 24 indicated that psychosocial HRQoL may deteriorate for EPB subjects when they enter adulthood.
authors.affiliation: Betanien University College, Bergen, Norway.
authors.forename: Berit
authors.initials: B
authors.lastname: Båtsvik
authors.affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Science, University of Bergen, Bergen, Norway.|Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
authors.forename: Bente J
authors.initials: BJ
authors.lastname: Vederhus
authors.affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: Thomas
authors.initials: T
authors.lastname: Halvorsen
authors.affiliation: Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.|Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway.|Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.
authors.forename: Tore
authors.initials: T
authors.lastname: Wentzel-Larsen
authors.affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.|Centre for Evidence-Based Practice, Bergen University College, Bergen, Norway.
authors.forename: Marit
authors.initials: M
authors.lastname: Graue
authors.affiliation: Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.|Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: Trond
authors.initials: T
authors.lastname: Markestad
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000523:psychology*; D008297:Male; D009664:Norway; D011788:Quality of Life; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Adolescence; Extremely premature infant; Health-related quality of life; Self-rated health; Young adulthood