title: PRP Augmentation for ACL Reconstruction.
abstract: Current research is investigating new methods to enhance tissue healing to speed up recovery time and decrease the risk of failure in Anterior Cruciate Ligament (ACL) reconstructive surgery. Biological augmentation is one of the most exploited strategies, in particular the application of Platelet Rich Plasma (PRP). Aim of the present paper is to systematically review all the preclinical and clinical papers dealing with the application of PRP as a biological enhancer during ACL reconstructive surgery. Thirty-two studies were included in the present review. The analysis of the preclinical evidence revealed that PRP was able to improve the healing potential of the tendinous graft both in terms of histological and biomechanical performance. Looking at the available clinical evidence, results were not univocal. PRP administration proved to be a safe procedure and there were some evidences that it could favor the donor site healing in case of ACL reconstruction with patellar tendon graft and positively contribute to graft maturation over time, whereas the majority of the papers did not show beneficial effects in terms of bony tunnels/graft area integration. Furthermore, PRP augmentation did not provide superior functional results at short term evaluation.
authors.affiliation: II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Luca
authors.identifier: 0000-0001-6352-9671
authors.initials: L
authors.lastname: Andriolo
authors.affiliation: II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Berardo
authors.initials: B
authors.lastname: Di Matteo
authors.affiliation: Nano-Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Kon
authors.affiliation: II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0002-8136-0977
authors.initials: G
authors.lastname: Filardo
authors.affiliation: II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Giulia
authors.identifier: 0000-0002-6355-4786
authors.initials: G
authors.lastname: Venieri
authors.affiliation: II Orthopaedic and Traumatology Clinic, Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano No. 1/10, 40136 Bologna, Italy.
authors.forename: Maurilio
authors.initials: M
authors.lastname: Marcacci
mesh_terms: D016118:Anterior Cruciate Ligament / Q000503:physiopathology / Q000601:surgery*; D059549:Anterior Cruciate Ligament Reconstruction / Q000379:methods*; D006801:Humans; D017847:Patellar Ligament / Q000503:physiopathology / Q000601:surgery*; D053657:Platelet-Rich Plasma; D014945:Wound Healing / Q000502:physiology