title: Association of the Derived Neutrophil-Lymphocyte Ratio With Critical Limb Ischemia.
abstract: Neutrophil and leukocyte counts are laboratory parameters that reflect the systemic inflammatory response in patients with atherosclerotic diseases. Based on the means of these parameters, the derived neutrophil-lymphocyte ratio (dNLR) can be calculated. We investigated a possible association of critical limb ischemia (CLI) and the dNLR in patients with peripheral arterial disease (PAD). We performed a retrospective data analysis including 1995 patients with PAD treated at our department in the years 2005 to 2010. The cohort was divided into tertiles according to dNLR. Higher dNLR values were associated with an increased CLI rate. In the tertile with lowest dNLR, the CLI rate was 20.4%, in the second tertile the CLI rate was 26.1%, and in the third tertile the CLI rate was 36.1%. Statistical significance was shown using a Jonckheere-Terpstra test (P < .001). A high dNLR is associated with an increased rate of CLI in patients with PAD. This might be a useful parameter to highlight patients at increased risk of CLI.
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Klara
authors.initials: K
authors.lastname: Belaj
authors.affiliation: Division of Oncology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Pichler
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Gerald
authors.initials: G
authors.lastname: Hackl
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Rief
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Eller
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Hafner
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria.
authors.forename: Marianne
authors.initials: M
authors.lastname: Brodmann
authors.affiliation: Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria thomas.gary@medunigraz.at.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gary
mesh_terms: D000368:Aged; D005121:Extremities; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D018655:Lymphocyte Count / Q000379:methods; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D058729:Peripheral Arterial Disease / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors
keywords: critical limb ischemia; derived neutrophil–lymphocyte ratio; peripheral arterial disease