title: Effect of donor age and parent-to-child transplant on living-related donor kidney transplantation: a single center's experience of 236 cases.
abstract: To study the impact of parent-to-child transplant and older donor age on recipients' post-transplant creatinine levels, a total of 236 patients who received living donor kidney transplantation were evaluated for kidney viability based on creatinine (Cr) level. Of the 236 pairings, 113 (48%) were parent-to-child followed by sibling transplants (66, 30%). Recipient Cr levels were significantly higher at 6 months and 3 years post-transplant in the parent-to-child transplants compared to other donor-recipient relationships. In addition, donor age (average age: 44.1 ± 11.5; range: 19-66) contributed to higher recipient post-transplant Cr levels (p < 0.01). Pre-transplant donor and recipient Cr levels tended to result in higher post-transplant Cr levels in recipients (p < 0.05). Multivariate logistic regression analysis revealed that the presence of both parent-to-child transplant and older donor significantly increased the risk of elevated post-transplant Cr levels in recipients with an estimated odds ratios ranging from 3.46 (95% CI: 1.71-6.98) at 6 months to 8.04 (3.14-20.56) at 3 years post-transplant. Donor age significantly affected transplant survival as measured by higher recipient post-transplant Cr levels. In addition, parent-to-child transplant pairings, along with older donor age, significantly increased the risk of elevated post-transplant Cr levels in recipients.
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Jiang
authors.initials: J
authors.lastname: Qiu
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Changxi
authors.initials: C
authors.lastname: Wang
authors.affiliation: b Department of Clinical Medicine , Sun Yet-sen Medical Academy of Sun Yat-sen University , Guangzhou , China.
authors.forename: Xianwei
authors.initials: X
authors.lastname: Liang
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Guodong
authors.initials: G
authors.lastname: Chen
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Qian
authors.initials: Q
authors.lastname: Fu
authors.affiliation: a Organ Transplant Department , The First Affiliated Hospital of Sun Yat-sen University , Guangzhou , China and.
authors.forename: Lizhong
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D064591:Allografts; D002648:Child; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D019520:Living Donors / Q000600:supply & distribution*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010287:Parent-Child Relations; D010290:Parents; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D035781:Siblings; D014181:Transplantation Immunology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003404:Creatinine
keywords: Kidney transplant; living donor; relatives; survival