title: Behavioral and neurodevelopmental precursors to binge-type eating disorders: support for the role of negative valence systems.
abstract: BACKGROUND
  Pediatric loss-of-control (LOC) eating is a robust behavioral precursor to binge-type eating disorders. Elucidating precursors to LOC eating and binge-type eating disorders may refine developmental risk models of eating disorders and inform interventions.
  
  
  METHODS
  We review evidence within constructs of the Negative Valence Systems (NVS) domain, as specified by the Research Domain Criteria framework. Based on published studies, we propose an integrated NVS model of binge-type eating-disorder risk.
  
  
  RESULTS
  Data implicate altered corticolimbic functioning, neuroendocrine dysregulation, and self-reported negative affect as possible risk factors. However, neuroimaging and physiological data in children and adolescents are sparse, and most prospective studies are limited to self-report measures.
  
  
  CONCLUSIONS
  We discuss a broad NVS framework for conceptualizing early risk for binge-type eating disorders. Future neural and behavioral research on the developmental trajectory of LOC and binge-type eating disorders is required.
authors.affiliation: Department of Medical and Clinical Psychology,Uniformed Services University of the Health Sciences,Bethesda,MD,USA.
authors.forename: A
authors.initials: A
authors.lastname: Vannucci
authors.affiliation: Section on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Nelson
authors.affiliation: Section on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Bongiorno
authors.affiliation: Section on Development and Affective Neuroscience of the National Institute of Mental Health,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Pine
authors.affiliation: Section on Growth and Obesity,Program in Developmental Endocrinology and Genetics,Eunice Kennedy Shriver National Institute of Child Health and Human Development,National Institutes of Health (NIH),DHHS,Bethesda,MD,USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Yanovski
authors.affiliation: Department of Medical and Clinical Psychology,Uniformed Services University of the Health Sciences,Bethesda,MD,USA.
authors.forename: M
authors.initials: M
authors.lastname: Tanofsky-Kraff
mesh_terms: D000293:Adolescent; D000375:Aging; D056912:Binge-Eating Disorder / Q000235:genetics*; D002648:Child; D005247:Feeding Behavior / Q000523:psychology*; D059647:Gene-Environment Interaction; D006801:Humans
keywords: Binge eating; Research Domain Criteria (RDoC); development; eating disorders; loss of control eating