title: X-ray structurally characterized sensors for ratiometric detection of Zn(2+) and Al(3+) in human breast cancer cells (MCF7): development of a binary logic gate as a molecular switch.
abstract: A very simple molecule derived from salicylaldehyde and N-phenyl ethylenediamine (L1) functions as dual-mode ratiometric fluorescence "turn on" sensors for Zn(2+) and Al(3+) at two different wavelengths. The sensing is based on the combined effect of inhibition of excited-state intra-molecular proton transfer (ESIPT), CH=N isomerization and chelation-enhanced fluorescence (CHEF). Moreover, the [L1-Zn(2+)] system functions as a better Al(3+) sensor where Al(3+) ratiometrically displaces Zn(2+) from the [L1-Zn(2+)] complex. Emission wavelength dependent differentiation of Zn(2+) and Al(3+) using L1 allows us to develop a binary logic gate that functions as a molecular switch. L1 efficiently detects Zn(2+) and Al(3+) in human breast cancer cells (MCF7) while the [L1-Zn(2+)] complex specifically detects Al(3+) in the said cells.
authors.affiliation: Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, India. ddas100in@yahoo.com.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Ghosh
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000535:Aluminum / Q000032:analysis*; D001940:Breast / Q000737:chemistry / Q000473:pathology; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D002412:Cations / Q000032:analysis; D002614:Chelating Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D005029:Ethylenediamines / Q000737:chemistry*; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D061848:Optical Imaging; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000032:analysis*
chemical_list: D000447:Aldehydes; D002412:Cations; D002614:Chelating Agents; D005029:Ethylenediamines; D005456:Fluorescent Dyes; C013243:salicylaldehyde; C031234:ethylenediamine; D000535:Aluminum; D015032:Zinc