title: Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function.
abstract: OBJECTIVE
  To evaluate the association between arterial stiffness and inflammatory markers including C-reactive protein (CRP), pentraxin 3 (PTX3) and neutrophil-to-lymphocyte ratio (NLR) in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function.
  
  
  METHODS
  A total of 52 ADPKD patients [mean (SD) age 38.2 (12.8) years, 69.2 % were females] with preserved renal function and 25 healthy volunteers [mean (SD) age 35.5 (6.5) years, 48.0 % were females] were included. Data on patient characteristics, blood biochemistry, inflammatory markers [PTX3 (pg/mL), CRP (mg/dL) and NLR] and arterial stiffness [large artery elasticity index (LAEI) (mL/mmHg × 10) and small artery elasticity index (SAEI) (mL/mmHg × 100)] were recorded in patient and control groups. Correlation between inflammatory markers and arterial stiffness parameters was analysed in patients.
  
  
  RESULTS
  Overall, 42.3 % of ADPKD patients were hypertensive and 44.4 % were receiving renin-angiotensin-aldosterone system (RAAS) blockade therapy. Median levels for PTX3 [442.0 (20.0-4140.0) pg/mL vs. 220.5 (14.7-393.0) pg/mL, p < 0.001] and SAEI [4.90 (1.60-11.80) mL/mmHg × 100 vs. 6.45 (2.80-15.70) mL/mmHg × 10, p = 0.013] were significantly higher in ADPKD patients than in controls. PTX3 and CRP were not correlated with arterial elasticity, while NLR was significantly correlated with LAEI negatively (Rho = -0.278, p = 0.042).
  
  
  CONCLUSIONS
  In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity.
authors.affiliation: Department of Nephrology, Sevket Yılmaz Training and Research Hospital, Bursa, Turkey, cumabulentgul@gmail.com.
authors.forename: Cuma Bulent
authors.initials: CB
authors.lastname: Gul
authors.forename: Abdulmecit
authors.initials: A
authors.lastname: Yildiz
authors.forename: Alparslan
authors.initials: A
authors.lastname: Ersoy
authors.forename: Serdar
authors.initials: S
authors.lastname: Kahvecioglu
authors.forename: Burak
authors.initials: B
authors.lastname: Asiltas
authors.forename: Fatih
authors.initials: F
authors.lastname: Yildirim
authors.forename: Selime
authors.initials: S
authors.lastname: Ermurat
authors.forename: Saim
authors.initials: S
authors.lastname: Sag
authors.forename: Aysegul
authors.initials: A
authors.lastname: Oruc
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Gullulu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gullulu
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007249:Inflammation / Q000097:blood; D007677:Kidney Function Tests / Q000379:methods; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D016891:Polycystic Kidney, Autosomal Dominant / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D063177:Pulse Wave Analysis / Q000379:methods; D000683:Serum Amyloid P-Component / Q000032:analysis*; D013223:Statistics as Topic; D059289:Vascular Stiffness; D000099153:Pentraxins
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins