title: Modified STOP-BANG questionnaire to predict obesity hypoventilation syndrome in obese subjects with obstructive sleep apnea.
abstract: OBJECTIVE
  The STOP-BANG questionnaire (SBQ) has never been studied in the context of its ability to predict obesity hypoventilation syndrome (OHS). Our aim was to evaluate the predictive performance of the original and modified SBQs for OHS in obese subjects with obstructive sleep apnea (OSA).
  
  
  METHODS
  Demographics, polysomnographic data, body mass index (BMI), Epworth Sleepiness Scale (ESS) scores, arterial blood gases, spirometric measurements, and SBQ scores were recorded. The modified SBQ was created by dividing BMI into ranges and adding the serum bicarbonate ranges.
  
  
  RESULTS
  The study included 196 obese subjects, of whom 17 had normal polysomnography. Of the remaining subjects, 105 had pure OSA and 74 had OHS with OSA. Both the original and modified SBQs scores were higher for the OHS subjects than for those with pure OSA (p < 0.001). An original SBQ score of ≥6 gave a satisfactory discrimination for OHS diagnosis (sensitivity 71.6 %, specificity 59.1 %, positive predictive value (PPV) 55.2 %, and negative predictive value (NPV) 74.7 %). The diagnostic OR for an original SBQ score of ≥6 for predicting OHS was 3.7. The sensitivity and NPV were increased for the modified SBQ (sensitivity 89.2 %, specificity 47.6 %, PPV 54.6 %, NPV 86.2 %), and the OR was 7.5. Both the original and modified SBQ scores were moderately correlated with ESS, AHI, ODI, lowest SpO2, and sleep time spent with SpO2 <90 %.
  
  
  CONCLUSIONS
  The modified SBQ can be used to screen for OHS in obese subjects.
authors.affiliation: Istanbul Faculty of Medicine, Department of Pulmonary Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Zuleyha
authors.initials: Z
authors.lastname: Bingol
authors.affiliation: Department of Pulmonary Medicine, Istanbul Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Pıhtılı
authors.affiliation: Istanbul Faculty of Medicine, Department of Pulmonary Medicine, Istanbul University, Istanbul, Turkey. kiyanesen@gmail.com.|Istanbul Tip Fakultesi, Gogus Hastaliklari Anabilim Dali, Istanbul Universitesi, 34360, Capa, Istanbul, Turkey. kiyanesen@gmail.com.
authors.forename: Esen
authors.initials: E
authors.lastname: Kıyan
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D010845:Obesity Hypoventilation Syndrome / Q000175:diagnosis*; D017286:Polysomnography; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis*; D013223:Statistics as Topic; D011795:Surveys and Questionnaires
keywords: Obesity; Obesity hypoventilation syndrome; STOP-BANG questionnaire