title: Sleep Disturbances in Depression.
abstract: Major depressive disorder is frequently accompanied by sleep disturbances such as insomnia or hypersomnia and polysomnographic sleep findings of increased rapid-eye-movement sleep and decreased slow wave sleep. For many patients, insomnia persists even after mood symptoms have been adequately treated. These patients have poorer outcomes than patients without sleep problems. These outcomes suggest that overlapping neural mechanisms regulate sleep and mood. Treatment of these patients can incorporate sedating antidepressants, nonbenzodiazepine γ-aminobutyric acid agonists, and cognitive behavioral therapy. Sleep restriction has been found to improve mood in depressed patients; however, the benefits typically disappear after recovery sleep.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Murphy
authors.affiliation: Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, 6001 Research Park Boulevard, Madison, WI 53719, USA; Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, B6/593 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA. Electronic address: mpeterson2@wisc.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Peterson
mesh_terms: D015897:Comorbidity; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy
keywords: Antidepressant; Cognitive behavioral therapy; Hypersomnia; Hypnotic; Insomnia; Major depressive disorder; Sleep