title: Correlation between biochemical indicators of blood lipid with cerebral vascular diseases.
abstract: OBJECTIVE
  The objective of this study was to investigate correlation of the changes in serum levels of cholesterol (chol), lipoprotein (a) (Lpa) and homocysteine (HCY) with incident cerebral infarction and cerebral hemorrhage.
  
  
  METHODS
  Data on a total of 418 patients (318 cerebral infarction events and 100 cerebral hemorrhage cases) were analyzed in this study. Serum chol and HCY levels were tested by means of GPO-PAP. Serum Lpa levels were measured using latex agglutination turbidimetry.
  
  
  RESULTS
  Patients with cerebral infarction showed significantly higher serum Lpa levels and anomaly ratio than those with cerebral hemorrhage (P<0.05), while no significant changes were identified for chol and HCY (P>0.05). Analyses by age indicated substantially increased Lpa concentration among cerebral infarction patients>60 years of age (P<0.05). No statistical significance was observed in other analyses carried out in the study.
  
  
  CONCLUSIONS
  These results demonstrate that Lpa concentration is clearly correlated with cerebral infarction incidence. Lpa may act as an independent risk factor and could be used as a biomarker for this disease.
authors.affiliation: Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
authors.forename: Jiarui
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Laboratory Medicine, 161 Hospital of PLA Wuhan 430010, Hubei, China.
authors.forename: Binjian
authors.initials: B
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008055:Lipids; D017270:Lipoprotein(a)
keywords: Cerebral infarction; cerebral hemorrhage; cholesterol; homocysteine; lipoprotein (a)