title: The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities.
abstract: Significant advances have been made over the past 25 years in our understanding of the most common adult solid tumors such as breast, colon, lung and prostate cancer. Much less is known about childhood solid tumors because they are rare and because they originate in developing organs during fetal development, childhood and adolescence. It can be very difficult to study the cellular origins of pediatric solid tumors in developing organs characterized by rapid proliferative expansion, growth factor signaling, developmental angiogenesis, programmed cell death, tissue reorganization and cell migration. Not only has the etiology of pediatric cancer remained elusive because of their developmental origins, but it also makes it more difficult to treat. Molecular targeted therapeutics that alter developmental pathway signaling may have devastating effects on normal organ development. Therefore, basic research focused on the mechanisms of development provides an essential foundation for pediatric solid tumor translational research. In this article, we describe new resources available for the developmental biology and oncology research communities. In a companion paper, we present the detailed characterization of an orthotopic xenograft of a pediatric solid tumor derived from sympathoadrenal lineage during development.
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Stewart
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Federico
authors.affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Asa
authors.initials: A
authors.lastname: Karlstrom
authors.affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Anang
authors.initials: A
authors.lastname: Shelat
authors.affiliation: Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Andras
authors.initials: A
authors.lastname: Sablauer
authors.affiliation: Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pappo
authors.affiliation: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: michael.dyer@stjude.org.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Dyer
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D045744:Cell Line, Tumor; D002648:Child; D002675:Child, Preschool; D057890:Epigenomics; D005818:Genetic Engineering; D023281:Genomics; D018197:Hepatoblastoma / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008545:Melanoma / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D058990:Molecular Targeted Therapy / Q000639:trends; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism; D012516:Osteosarcoma / Q000378:metabolism; D012175:Retinoblastoma / Q000378:metabolism; D012208:Rhabdomyosarcoma / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000378:metabolism
keywords: Childhood solid tumors; Epigenomics; Genetically engineered mouse models; Genomics; Xenograft