title: Induction of long-term oscillations in the γ frequency band by nAChR activation in rat hippocampal CA3 area.
abstract: The hippocampal neuronal network oscillation at γ frequency band (γ oscillation) is generated by the precise interaction between interneurons and principle cells. γ oscillation is associated with attention, learning and memory and is impaired in the diseased conditions such as Alzheimer's disease (AD) and schizophrenia. Nicotinic acetylcholine receptor (nAChR) plays an important role in the regulation of hippocampal neurotransmission and network activity. It is not known whether nicotine modulates plasticity of network activity at γ oscillations in the hippocampus. In this study we investigated the effects of nicotine on the long-term changes of KA-induced γ oscillations. We found that hippocampal γ oscillations can be enhanced by a low concentration of nicotine (1μM), such an enhancement lasts for hours after washing out of nicotine, suggesting a form of synaptic plasticity, named as long-term oscillation at γ frequency band (LTOγ). Nicotine-induced LTOγ was mimicked by the selective α4β2 but not by α7 nAChR agonist and was involved in N-methyl-d-aspartate (NMDA) receptor activation as well as depended on excitatory and inhibitory neurotransmission. Our results indicate that nAChR activation induced plasticity in γ oscillation, which may be beneficial for the improvement of cognitive deficiency in AD and schizophrenia.
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Ge
authors.affiliation: Department of Pathophysiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: J G
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China.
authors.forename: P P
authors.initials: PP
authors.lastname: Li
authors.affiliation: Key Laboratory of Brain Research of Henan Province, Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang 453003, Henan, PR China. Electronic address: Johnlu9000@hotmail.com.
authors.forename: C B
authors.initials: CB
authors.lastname: Lu
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000502:physiology*; D065818:Gamma Rhythm / Q000502:physiology*; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D009473:Neuronal Plasticity; D009538:Nicotine / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic / Q000502:physiology*
chemical_list: D018722:Nicotinic Agonists; D016194:Receptors, N-Methyl-D-Aspartate; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; D009538:Nicotine; D007608:Kainic Acid
keywords: hippocampus; long-term oscillation; neural network oscillation; nicotinic acetylcholine receptor