title: Is ionized oxygen negatively or positively charged more effective for carboxyhemoglobin reduction compare to medical oxygen at atmospheric pressure?
abstract: Carbon monoxide (CO) reversibly binds to hemoglobin forming carboxyhemoglobin (COHb). CO competes with O(2) for binding place in hemoglobin leading to tissue hypoxia. Already 30 % saturation of COHb can be deadly. Medical oxygen at atmospheric pressure as a therapy is not enough effective. Therefore hyperbaric oxygen O(2) inhalation is recommended. There was a question if partially ionized oxygen can be a better treatment at atmospheric pressure. In present study we evaluated effect of partially ionized oxygen produced by device Oxygen Ion 3000 by Dr. Engler in elimination of COHb in vitro experiments and in smokers. Diluted blood with different content of CO was purged with 5 l/min of either medicinal oxygen O(2), negatively ionized O(2) or positively ionized O(2) for 15 min, then the COHb content was checked. In vivo study, 15 smokers inhaled of either medicinal oxygen O(2) or negatively ionized O(2), than we compared CO levels in expired air before and after inhalation. In both studies we found the highest elimination of CO when we used negatively ionized O(2). These results confirmed the benefit of short inhalation of negatively ionized O(2), in frame of Ionized Oxygen Therapy (I O(2)Th/Engler) which could be used in smokers for decreasing of COHb in blood.
authors.affiliation: Department of Occupational Medicine and Clinical Toxicology, Faculty of Medicine, Pavol Jozef Safarik University and the L. Pasteur University Hospital, Košice, Slovakia. slavomir.perecinsky@upjs.sk.
authors.forename: S
authors.initials: S
authors.lastname: Perečinský
authors.forename: I
authors.initials: I
authors.lastname: Kron
authors.forename: I
authors.initials: I
authors.lastname: Engler
authors.forename: L
authors.initials: L
authors.lastname: Murínová
authors.forename: V
authors.initials: V
authors.lastname: Donič
authors.forename: M
authors.initials: M
authors.lastname: Varga
authors.forename: A
authors.initials: A
authors.lastname: Marossy
authors.forename: Ľ
authors.initials: Ľ
authors.lastname: Legáth
mesh_terms: D002249:Carbon Monoxide Poisoning / Q000628:therapy*; D006801:Humans; D007477:Ions / Q000627:therapeutic use*; D010100:Oxygen / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D007477:Ions; D010100:Oxygen