title: Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase.
abstract: Malignant fibrous histiocytoma (MFH) of the breast and visceral organs is extremely rare. There is an incomplete understanding of the clinical pathology of the primary MFH originating from the breast and visceral organs, especially in comparison with other soft tissue sarcomas. As a consequence we searched and analyzed the clinical and pathological records of all the nine patients with diagnosed breast and visceral MFH in our hospital. Immunohistochemical staining was performed for ezrin and HMG-CoA reductase in these MFH cases and relevant mesenchymal sarcomas. The 9 MFH cases presented with nonspecific symptoms and imaging manifestations. 6 cases were classified as storiform-pleomorphic MFH, 2 cases as inflammatory MFH, and the remaining 1 case as giant cell MFH. The results showed that ezrin expression, as well as HMG-CoA reductase expression, was significantly stronger in MFH cases than other non-MFH sarcomas. Poor prognosis seemed to be associated with younger age. Certain characteristics and clinicopathologic features can help us making the diagnosis of MFH. In conclusion, our study provided the potential value of ezrin and HMG-CoA reductase for diagnosis and differential diagnosis of MFH located in the breast and visceral organs. More accurate prognostic information of this rare disease needed to be further investigated.
authors.affiliation: Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China ; Jiangsu Province's Key Medical Center for Liver Surgery Nanjing 210008, China ; Institute of Hepatobiliary Surgery, Nanjing University Nanjing 210008, China.
authors.forename: Jinyang
authors.initials: J
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China ; Jiangsu Province's Key Medical Center for Liver Surgery Nanjing 210008, China ; Institute of Hepatobiliary Surgery, Nanjing University Nanjing 210008, China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
authors.forename: Halmurat
authors.initials: H
authors.lastname: Obulkasim
authors.affiliation: Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Duan
authors.affiliation: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Deng
authors.affiliation: Nanjing University of Chinese Medicine Nanjing 210000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zou
authors.affiliation: Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China ; Jiangsu Clinical Medical Center of Digestive Disease Nanjing 210008, China ; Jiangsu Province's Key Medical Center for Liver Surgery Nanjing 210008, China ; Institute of Hepatobiliary Surgery, Nanjing University Nanjing 210008, China.
authors.forename: Yitao
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D003598:Cytoskeletal Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000175:diagnosis*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000032:analysis / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D014781:Viscera / Q000473:pathology; D000099149:Ezrin
chemical_list: D014408:Biomarkers, Tumor; D003598:Cytoskeletal Proteins; D006903:Hydroxymethylglutaryl CoA Reductases; D000099149:Ezrin
keywords: HMG-CoA reductase; Malignant fibrous histiocytoma; breast; ezrin; visceral organs