title: Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study.
abstract: The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C. pneumoniae and H. p ylori, osteoprotegerin (OPG), the receptor activator of nuclear factor kappa B ligand (RANKL), CrossLaps, and osteocalcin. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine at baseline and at follow-up 5.8 years later. There were no significant differences in age-adjusted bone turnover markers, OPG, RANKL, the RANKL/OPG ratio, and BMD between the C. p neumoniae and H. p ylori IgG seropositive and seronegative subjects (P > 0.05). Neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine or bone loss at the 5.8-year follow-up. In logistic regression analysis, neither C. p neumoniae nor H. p ylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss in postmenopausal women. In addition, chronic infection with C. p neumoniae or H. p ylori did not predict incident osteoporosis among this group of women.
authors.affiliation: Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Kalantarhormozi
authors.affiliation: The Persian Gulf Nuclear Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.affiliation: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Vahdat
authors.affiliation: Division of Endocrinology and Metabolism, University of Kansas Medical Center, Kansas City, KS, USA.
authors.forename: Kamyar
authors.initials: K
authors.lastname: Asadipooya
authors.affiliation: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Ostovar
authors.affiliation: Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Katayoun
authors.initials: K
authors.lastname: Raissi
authors.affiliation: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Darabi
authors.affiliation: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Shokrollah
authors.initials: S
authors.lastname: Farrokhi
authors.affiliation: Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Sina
authors.initials: S
authors.lastname: Dobaradaran
authors.affiliation: Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Farrokhnia
authors.affiliation: Department of Biochemistry, The Persian Gulf Marine Biotechnology Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran. inabipour@gmail.com.|The Persian Gulf Tropical Medicine Research Center, Boostan 19 Alley, Imam Khomeini St, 7514763448, Bushehr, Iran. inabipour@gmail.com.
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D015992:Body Mass Index; D023521:Chlamydophila Infections / Q000097:blood* / Q000473:pathology; D016993:Chlamydophila pneumoniae; D005260:Female; D005272:Femur Neck / Q000378:metabolism / Q000473:pathology; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000097:blood* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008161:Lumbosacral Region / Q000473:pathology; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood* / Q000473:pathology; D011446:Prospective Studies; D013131:Spine / Q000378:metabolism / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G
keywords: Bone mineral density; Chlamydia pneumoniae; Helicobacter pylori; Osteoporosis