title: Influence of intraocular astigmatism on the correction of myopic astigmatism by femtosecond laser small-incision lenticule extraction.
abstract: OBJECTIVE
  To evaluate the influence of the origin of astigmatism on the correction of myopia or myopic astigmatism by femtosecond laser small-incision lenticule extraction (SMILE).
  
  
  METHODS
  Ophthalmology Department, Eye and ENT Hospital, Shanghai, China.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Small-incision lenticule extraction was performed to correct myopia or myopic astigmatism. Ocular residual astigmatism (ORA) was determined by vector analysis using manifest refraction and Scheimpflug camera imaging of the anterior cornea. Patients were divided into 2 groups according to ORA (high >1.0 diopter [D]; low ≤1.0 D), and procedural efficacy was compared. Patients were examined preoperatively and 1, 3, and 6 months postoperatively.
  
  
  RESULTS
  This study comprised 122 right eyes of 122 patients. No significant difference was found in the preoperative manifest astigmatism (target-induced astigmatism [TIA]) between the low ORA group (n = 67) and high ORA group (n = 55). The mean postoperative manifest astigmatism was higher in the high ORA group at all postoperative timepoints (1 month: t = 2.182, P=.031; 3 months: t = 2.30, P=.023; 6 months: t = 2.193, P=.03). The mean index of success (postoperative astigmatism/TIA) was 0.68 in the high ORA group and 0.34 in the low ORA group 1 month postoperatively (t = 2.531, P=.013); 0.73 and 0.39, respectively, at 3 months (t = 2.689, P=.008); and 0.77 and 0.46, respectively, at 6 months (t = 2.105, P=.037).
  
  
  CONCLUSIONS
  Small-incision lenticule extraction was effective in correcting astigmatism but may be less effective in correcting ORA.
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Yishan
authors.initials: Y
authors.lastname: Qian
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Renyuan
authors.initials: R
authors.lastname: Chu
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Meiyan
authors.initials: M
authors.lastname: Li
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA. Electronic address: xingtaozhou@163.com.
authors.forename: Xingtao
authors.initials: X
authors.lastname: Zhou
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Olszewski
authors.affiliation: From the Department of Ophthalmology, Eye and ENT Hospital, Fudan University, and the Key Laboratory of Myopia of State Health Ministry (Qian, Huang, Chu, Zhao, Li, Zhou), Shanghai, China; the Department of Surgery (Olszewski), Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, and Johns Hopkins University School of Medicine (Wang), Baltimore, Maryland, USA.
authors.forename: Yutung
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001251:Astigmatism / Q000503:physiopathology*; D003315:Cornea / Q000503:physiopathology; D003319:Corneal Stroma / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D054140:Refractive Surgical Procedures; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult