title: Effects of angiotensin-converting enzyme inhibition and bradykinin peptides in rats with myocardial infarction.
abstract: OBJECTIVE
  Angiotensin-converting enzyme (ACE) inhibitors have been reported to decrease myocardial remodeling and faciliate cardiac function improvement in the setting myocardial infarction by affecting bradykinin. The purpose of this study was to evaluate the combination effects of perindopril and bradykinin (BK) in rats with myocardial infarction.
  
  
  METHODS
  Wistar Rats underwent to left anterior descending (LAD) coronary artery ligation were allocated into MI group (n=6); Perindopril group (n=7); Perindopril+BK group (n=7). An additional sham operation group (Sham group, n=6) were also established. After 4 weeks, the left ventricle function, myocardial tissue morphology, myocardial collagen volume faction, infracted ventricular wall thickness, myocardial infarction area and neovascular formation were evaluated.
  
  
  RESULTS
  Combination treatment with perindopril and BK were showed significant improvement on LVEDV, LVEF and LVFS than MI group. Moreover, a significant improvement on LVEF was found in Perindopril+BK group than Perindopril group but not on LVEDV and LVFS between these two groups. Furthermore, neo-vessel density was significantly increased in Perindopril+BK group than other groups while no significant improvement on vessel density was found after the treatment of perindopril. In addition, myocardial infarction thickness improvement was found in Perindopril and group than MI group while combination treatment with perindopril and BK can significant improve the myocardial infarction thickness than perindopril only.
  
  
  CONCLUSIONS
  Combination treatment with ACE inhibitor perindopril and BK can significantly improve the ventricle function in the rat model of myocardial infarction. Our data suggest BK can serve as adjuvant treatment in myocardial infarction treatment.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qu
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University Wuhan 430060, China.
authors.forename: Hongxin
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University Wuhan 430060, China ; Department of Anatomy, Basic Medical College of Wuhan University Wuhan 430071, China.
authors.forename: Yihao
authors.initials: Y
authors.lastname: Tian
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D020913:Perindopril / Q000494:pharmacology*; D017208:Rats, Wistar; D020127:Recovery of Function; D013318:Stroke Volume / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D043925:Angiogenesis Inducing Agents; D000806:Angiotensin-Converting Enzyme Inhibitors; D002316:Cardiotonic Agents; D010446:Peptide Fragments; D003094:Collagen; D001920:Bradykinin; D020913:Perindopril
keywords: Myocardial infarction; angiotensin-converting enzyme (ACE) inhibitors; bradykinin (BK); perindopril