title: Regulation of Muscle Satellite Cell Function in Tissue Homeostasis and Aging.
abstract: Age-related muscle decline is associated with functional impairment of satellite cells (SCs). Conflicting data suggest dysregulation of cell-extrinsic or -intrinsic factors can independently contribute to such impairment. Here, we emphasize the importance of identifying nodes that integrate these factors into feed-forward circuits, which could provide targets for therapeutic intervention.
authors.affiliation: Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: asacco@sanfordburnham.org.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Sacco
authors.affiliation: Development, Aging and Regeneration Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Epigenetics and Regenerative Medicine, IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, Rome, Italy. Electronic address: lpuri@sanfordburnham.org.
authors.forename: Pier Lorenzo
authors.initials: PL
authors.lastname: Puri
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D006706:Homeostasis; D006801:Humans; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology*; D015398:Signal Transduction