title: Triglyceride to HDL-C ratio and increased arterial stiffness in apparently healthy individuals.
abstract: OBJECTIVE
  High triglycerides and low high density lipoprotein cholesterol are important cardiovascular risk factors. Triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) has been reported to be useful in predicting cardiovascular disease. Brachial-ankle pulse wave velocity (baPWV) is a valid and reproducible measurement by which to assess arterial stiffness and a surrogate marker of atherosclerosis. However, there is limited evidence about the relationship between them. Therefore, we tested the hypotheses that TG/HDL-C is associated with baPWV in healthy individuals.
  
  
  METHODS
  Fasting lipid profiles, baPWV and clinical data were measured in 1498 apparently healthy, medication-free subjects (926 men, 572 women) who participated in a routine health screening from 2011 to 2013. Participants were stratified into quartiles of TG/HDL-C ratio. BaPWV > 1400 cm/s was defined as abnormal baPWV, Multivariable logistic regression was used to identify associations of TG/HDL-C quartiles and baPWV, after adjusting for the presence of conventional cardiovascular risk factors.
  
  
  RESULTS
  In both genders, we observed positive relationships between TG/HDL-C quartiles and BMI, systolic BP, diastolic BP, fasting glucose, total cholesterol, LDL-C, triglycerides, uric acid, and percentages of high baPWV. Multivariable logistic regression revealed that baPWV abnormality OR value of the highest TG/HDL-C quartiles was 1.91 (95% CI: 1.11-3.30, P < 0.05) and 2.91 (95% CI: 1.02-8.30, P < 0.05) in male and female after adjusting for age, systolic BP, diastolic BP, BMI, fasting plasma glucose, LDL-C, uric acid and estimated glomerular filtration rate when compared with the lowest TG/HDL-C quartiles.
  
  
  CONCLUSIONS
  Increased TG/HDL-C was independently associated with baPWV abnormality in apparently healthy individuals.
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Wen
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Yu-Yu
authors.initials: YY
authors.lastname: Zhong
authors.affiliation: Department of Endocrinology, Jiangmen Central Hospital Jiangmen 529070, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Wen
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Chao-Qun
authors.initials: CQ
authors.lastname: Kuang
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Jie-Rong
authors.initials: JR
authors.lastname: Liao
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Pei-Shen
authors.initials: PS
authors.lastname: Wang
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Yue-Xia
authors.initials: YX
authors.lastname: Wu
authors.affiliation: Department of Nephrology, Jiangmen Central Hospital Jiangmen 529070, China.
authors.forename: Chu-Jun
authors.initials: CJ
authors.lastname: Ouyang
authors.affiliation: Department of Health Examination, Jiangmen Central Hospital Jiangmen, Guangdong, 529070, China.
authors.forename: Zhi-Jin
authors.initials: ZJ
authors.lastname: Chen
keywords: Arterial stiffness; pulse wave velocity; triglyceride to HDL-C Ratio