title: Bile acid-induced cholemic nephropathy.
abstract: Kidney injury in deeply jaundiced patients became known as cholemic nephropathy. This umbrella term covers impaired renal function in cholestatic patients with characteristic histomorphological changes including intratubular cast formation and tubular epithelial cell injury. Cholemic nephropathy represents a widely underestimated but important cause of kidney dysfunction in patients with cholestasis and advanced liver disease. However, the nomenclature is inconsistent since there are numerous synonyms used; the underlying mechanisms of cholemic nephropathy are not entirely clear, and widely accepted diagnostic criteria are still missing. Consequently, the current article aims to summarize the present knowledge on the clinical and morphological characteristics, available preclinical models, derived potential pathomechanisms, and future diagnostic and therapeutic strategies in cholemic nephropathy. Furthermore, we provide a potential research agenda for this evolving field.
authors.affiliation: Research Unit for Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Krones
authors.forename: Martin
authors.initials: M
authors.lastname: Wagner
authors.forename: Kathrin
authors.initials: K
authors.lastname: Eller
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Rosenkranz
authors.forename: Michael
authors.initials: M
authors.lastname: Trauner
authors.forename: Peter
authors.initials: P
authors.lastname: Fickert
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D001647:Bile Acids and Salts / Q000378:metabolism*; D002779:Cholestasis / Q000150:complications* / Q000378:metabolism; D006530:Hepatorenal Syndrome / Q000209:etiology; D006801:Humans; D041781:Jaundice, Obstructive / Q000150:complications* / Q000378:metabolism; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology*; D009626:Terminology as Topic
chemical_list: D001647:Bile Acids and Salts