title: A rapid, efficient, and facile solution for dental hypersensitivity: The tannin-iron complex.
abstract: Dental hypersensitivity due to exposure of dentinal tubules under the enamel layer to saliva is a very popular and highly elusive technology priority in dentistry. Blocking water flow within exposed dentinal tubules is a key principle for curing dental hypersensitivity. Some salts used in "at home" solutions remineralize the tubules inside by concentrating saliva ingredients. An "in-office" option of applying dense resin sealants on the tubule entrance has only localized effects on well-defined sore spots. We report a self-assembled film that was formed by facile, rapid (4 min), and efficient (approximately 0.5 g/L concentration) dip-coating of teeth in an aqueous solution containing a tannic acid-iron(III) complex. It quickly and effectively occluded the dentinal tubules of human teeth. It withstood intense tooth brushing and induced hydroxyapatite remineralisation within the dentinal tubules. This strategy holds great promise for future applications as an effective and user-friendly desensitizer for managing dental hypersensitivity.
authors.affiliation: POSTECH Ocean Science and Technology, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Dongyeop X
authors.initials: DX
authors.lastname: Oh
authors.affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Ekavianty
authors.initials: E
authors.lastname: Prajatelistia
authors.affiliation: Dental Research Institute and Department of Biomaterials Science, School of Dentistry, Seoul National University, Seoul 110-749, Korea.
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Ju
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Hyo
authors.initials: H
authors.lastname: Jeong Kim
authors.affiliation: Dental Research Institute and Department of Biomaterials Science, School of Dentistry, Seoul National University, Seoul 110-749, Korea.
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Baek
authors.affiliation: Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Hyung
authors.initials: H
authors.lastname: Joon Cha
authors.affiliation: Department of Dentistry, Anam Hospital, Korea University Medical Centre, Seoul 136-705, Korea.
authors.forename: Sang
authors.initials: S
authors.lastname: Ho Jun
authors.affiliation: Dental Research Institute and Department of Biomaterials Science, School of Dentistry, Seoul National University, Seoul 110-749, Korea.
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Ahn
authors.affiliation: 1] POSTECH Ocean Science and Technology, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea [2] School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea [3] School of Environmental Science and Engineering, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea.
authors.forename: Dong
authors.initials: D
authors.lastname: Soo Hwang
mesh_terms: D018929:Cell Culture Techniques; D003807:Dentin Sensitivity / Q000188:drug therapy*; D019234:Dentinal Fluid / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000737:chemistry; D010513:Periodontal Ligament / Q000166:cytology; D019999:Pharmaceutical Solutions / Q000008:administration & dosage* / Q000737:chemistry; D013634:Tannins / Q000737:chemistry; D014070:Tooth / Q000187:drug effects
chemical_list: D019999:Pharmaceutical Solutions; D013634:Tannins; D007501:Iron