title: C21 steroidal glycosides from the roots of Cynanchum saccatum.
abstract: Eight new C21 steroidal glycosides, named cynsaccatols A-H (1-8), along with two known analogs (9-10), were isolated from the roots of Cynanchum saccatum. Their structures were determined on the basis of detailed spectroscopic analysis, as well as HRESIMS. All compounds (1-10) were tested for their cytotoxicity in vitro using three human cancer cell lines (HepG2, Hela and U251), and compounds 1, 4, 5, 9, 10 showed weak inhibitory activities against different cell lines, respectively.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Rao
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: baocaili@hotmail.com.
authors.forename: Bao-Cai
authors.initials: BC
authors.lastname: Li
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. Electronic address: pli1978@hotmail.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D031105:Cynanchum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D013256:Steroids
keywords: Bioactivity; C(21) steroidal glycosides; Chemical constituent; Cynanchum saccatum; Cytotoxicity