title: Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
abstract: The pathogenesis of neurodegenerative diseases involves altered activity of proteolytic systems and accumulation of protein aggregates. Autophagy is an intracellular process in which damaged organelles and long-lived proteins are degraded and recycled for maintaining normal cellular homeostasis. Disruption of autophagic activity in neurons leads to modify the cellular homeostasis, causing deficient elimination of abnormal and toxic protein aggregates that promotes cellular stress and death. Therefore, induction of autophagy has been proposed as a reasonable strategy to help neurons to clear abnormal protein aggregates and survive. This review aims to give an overview of some of the main modulators of autophagy that are currently being studied as possible alternatives in the search of therapies that slow the progression of neurodegenerative diseases, which are incurable to date.
authors.forename: Rosa Ana
authors.initials: RA
authors.lastname: González-Polo
authors.forename: Elisa
authors.initials: E
authors.lastname: Pizarro-Estrella
authors.forename: Sokhna M S
authors.initials: SM
authors.lastname: Yakhine-Diop
authors.forename: Mario
authors.initials: M
authors.lastname: Rodríguez-Arribas
authors.forename: Rubén
authors.initials: R
authors.lastname: Gómez-Sánchez
authors.forename: José M Bravo-San
authors.initials: JM
authors.lastname: Pedro
authors.affiliation: Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, Departamento de Bioquimica y Biologia Molecular y Genetica. Universidad de Extremadura, F. Enfermeria y Terapia Ocupacional, 10003 Caceres, Spain. jfuentes@unex.es.
authors.forename: José M
authors.initials: JM
authors.lastname: Fuentes
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects* / Q000502:physiology*; D004195:Disease Models, Animal; D005502:Food; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D000077185:Resveratrol; D020123:Sirolimus / Q000494:pharmacology; D013095:Spermidine / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology*; D013454:Sulfoxides; D014199:Trehalose / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D017879:Isothiocyanates; D013267:Stilbenes; D013454:Sulfoxides; D014635:Valproic Acid; D008094:Lithium; D014199:Trehalose; C016766:sulforaphane; D000077185:Resveratrol; D013095:Spermidine; D020123:Sirolimus