title: Dietary bioactive peptides: Human studies.
abstract: Current opinion strongly links nutrition and health. Among nutrients, proteins, and peptides which are encrypted in their sequences and released during digestion could play a key role in improving health. These peptides have been claimed to be active on a wide spectrum of biological functions or diseases, including blood pressure and metabolic risk factors (coagulation, obesity, lipoprotein metabolism, and peroxidation), gut and neurological functions, immunity, cancer, dental health, and mineral metabolism. A majority of studies involved dairy peptides, but the properties of vegetal, animal, and sea products were also assessed. However, these allegations are mainly based on in vitro and experimental studies which are seldom confirmed in humans. This review focused on molecules which were tested in humans, and on the mechanisms explaining discrepancies between experimental and human studies.
authors.affiliation: a Service de Pédiatrie, CHU de Caen , Caen , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Bouglé
authors.affiliation: b STLO, UMR1253, INRA, Agrocamus Ouest , Rennes , France.
authors.forename: Saïd
authors.initials: S
authors.lastname: Bouhallab
mesh_terms: D000818:Animals; D004044:Dietary Proteins / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D019587:Dietary Supplements / Q000009:adverse effects; D004063:Digestion; D005285:Fermentation; D005511:Food Handling; D006801:Humans; D008460:Meat / Q000009:adverse effects; D008894:Milk Proteins / Q000009:adverse effects / Q000378:metabolism; D008954:Models, Biological; D010446:Peptide Fragments / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D010455:Peptides / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D011492:Protein Hydrolysates / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D055550:Protein Stability; D015203:Reproducibility of Results; D017747:Seafood / Q000009:adverse effects
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D010446:Peptide Fragments; D010455:Peptides; D011492:Protein Hydrolysates
keywords: Bioactive peptides; blood pressure; cancer; human; immunity; metabolism; minerals