title: The Relationship between the p.V37I Mutation in GJB2 and Hearing Phenotypes in Chinese Individuals.
abstract: The most common cause of nonsyndromic autosomal recessive hearing loss is mutations in GJB2. The mutation spectrum and prevalence of mutations vary significantly among ethnic groups, and the relationship between p.V37I mutation in GJB2 and the hearing phenotype is controversial. Among the 3,864 patients in this study, 106 (2.74%) had a homozygous p.V37I variation or a compound p.V37I plus other GJB2 pathogenic mutation, a frequency that was significantly higher than that in the control group (600 individuals, 0%). The hearing loss phenotype ranged from mild to profound in all patients with the homozygous p.V37I variation or compound p.V37I plus other GJB2 pathogenic mutation. There was no difference in the distribution of the hearing level in the group with the homozygous p.V37I variation and the group with the compound p.V37I variation plus pathogenic mutation. Most patients (66.04%) with the V37I-homozygous variation or p.V37I plus other pathogenic mutation had a mild or moderate hearing level. This study found a definite relationship between p.V37I and deafness, and most patients who carried the pathogenic combination with p.V37I mutation had mild or moderate hearing loss. Therefore, otolaryngologists should consider that the milder phenotype might be caused by the GJB2 p.V37I mutation.
authors.affiliation: Department of Otolaryngology, PLA General Hospital, Do.28 Fuxing Road, Beijing, People's Republic of China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, Hainan Branch of PLA General Hospital, Haitang Bay, Sanya, People's Republic of China.
authors.forename: Bangqing
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology, PLA General Hospital, Do.28 Fuxing Road, Beijing, People's Republic of China.
authors.forename: Guojian
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, PLA General Hospital, Do.28 Fuxing Road, Beijing, People's Republic of China; Department of Otolaryngology, Hainan Branch of PLA General Hospital, Haitang Bay, Sanya, People's Republic of China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Otolaryngology, PLA General Hospital, Do.28 Fuxing Road, Beijing, People's Republic of China.
authors.forename: Pu
authors.initials: P
authors.lastname: Dai
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D005260:Female; D034381:Hearing Loss / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D017630:Connexins; C000607042:GJB2 protein, human; D000072259:Connexin 26