title: Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age.
abstract: Oxidative stress is a major determinant of human aging and common hallmark of age-related diseases. A protective role against free radicals accumulation was shown for thioredoxin reductase TrxR1, a key antioxidant selenoprotein. The variability of encoding gene (TXNRD1) was previously found associated with physical status at old age and extreme survival in a Danish cohort. To further investigate the influence of the gene variability on age-related physiological decline, we analyzed 9 tagging SNPs in relation to markers of physical (Activity of Daily Living, Hand Grip, Chair stand, and Walking) and cognitive (Mini Mental State Examination) status, in a Southern-Italian cohort of 64-107 aged individuals. We replicated the association of TXNRD1 variability with physical performance, with three variants (rs4445711, rs1128446, and rs11111979) associated with physical functioning after 85 years of age (p < 0.022). In addition, we found two SNPs borderline influencing longevity (rs4964728 and rs7310505) in our cohort, the last associated with health status and survival in Northern Europeans too. Overall, the evidences of association in a different population here reported extend the proposed role of TXNRD1 gene in modulating physical decline at extreme ages, further supporting the investigation of thioredoxin pathway in relation to the quality of human aging.
authors.affiliation: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Dato
authors.affiliation: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
authors.forename: Francesco
authors.identifier: 0000-0001-8325-4812
authors.initials: F
authors.lastname: De Rango
authors.affiliation: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
authors.forename: Paolina
authors.initials: P
authors.lastname: Crocco
authors.affiliation: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0003-4701-9748
authors.initials: G
authors.lastname: Passarino
authors.affiliation: Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy.
authors.forename: Giuseppina
authors.identifier: 0000-0002-4264-4184
authors.initials: G
authors.lastname: Rose
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D000975:Antioxidants / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008136:Longevity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011594:Psychometrics; D011788:Quality of Life; D054481:Thioredoxin Reductase 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D000975:Antioxidants; C516124:TXNRD1 protein, human; D054481:Thioredoxin Reductase 1