title: Anti-diabetic effect of 2,5-dimethoxy(4-methoxyphenyl)benzamide.
abstract: This study was undertaken to identify new anti-diabetic substances, and we successfully identified the new potent anti-diabetic agent 2,5-dimethoxy(4-methoxyphenyl)benzamide (DMPB). The glucose uptake of C2C12 muscle cells more than doubled following treatment with 50 μM DMPB. This compound also enhanced the expressions of pAMPK, pACC, and pAKT, which are target proteins for glucose uptake improvement in C2C12 cells. Moreover, DMPB increased the transcriptional activity of the peroxisome proliferator-activated receptor in HEK 293 kidney cells. These results suggest that DMPB has potential as an anti-diabetic substance.
authors.forename: Jin Taek
authors.initials: JT
authors.lastname: Hwang
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
authors.forename: Sang Yoon
authors.initials: SY
authors.lastname: Choi
mesh_terms: D000840:Anisoles / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D057809:HEK293 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D009132:Muscles / Q000166:cytology / Q000187:drug effects; D047495:PPAR gamma / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: C000601309:2,5-dimethoxy(4-methoxyphenyl)benzamide; D000840:Anisoles; D001549:Benzamides; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D005947:Glucose