title: Lymph Node Metastasis from Tall-Cell Thyroid Cancer Negative on 18F-FDG PET/CT and Detected by 18F-Choline PET/CT.
abstract: A 77-year-old woman underwent thyroidectomy and (131)I remnant ablation for tall-cell differentiated cancer (DTC) of the left lobe. Detectable Tg levels (4.1 μg/L) under TSH suppression, with undetectable serum Tg-antibody levels, prompted neck ultrasonography, which revealed a lymph node in the left laterocervical region and in the right retroclavicular region. (18)F-FDG PET/CT showed uptake by the left lymph node. (18)F-choline PET/CT showed increased uptake by both lymph nodes. Histopathology revealed DTC solid metastasis in the left lymph node and solid and cystic metastasis in the right one. (18)F-choline PET/CT can locate virulent DTC recurrence, thereby increasing (18)F-FDG PET/CT information.
authors.affiliation: From the *Nuclear Medicine Unit, †Pathology Unit, ‡Surgery Unit, and §Internal Medicine, Galliera Hospital, Genoa, Italy.
authors.forename: Arnoldo
authors.initials: A
authors.lastname: Piccardo
authors.forename: Michela
authors.initials: M
authors.lastname: Massollo
authors.forename: Roberto
authors.initials: R
authors.lastname: Bandelloni
authors.forename: Anselmo
authors.initials: A
authors.lastname: Arlandini
authors.forename: Luca
authors.initials: L
authors.lastname: Foppiani
mesh_terms: D000368:Aged; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008207:Lymphatic Metastasis; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; C516370:fluoromethylcholine; D019788:Fluorodeoxyglucose F18; D002794:Choline