title: Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments.
abstract: Acne is a common and complex skin disease, with a very complex pathogenesis. Although in women the relationship between acne and insulin resistance is well known, in particular in women with PCOS, in males this relationship has been poorly investigated. In total, 20 subjects with an altered metabolic profile were considered for this study and randomized as follows: 10 patients were treated with metformin plus a hypocaloric diet for 6 months (group A), while 10 patients did not receive any treatment with metformin and were only followed up (group B). All patients of group A, after 6 months of metformin therapy, had a statistically significant improvement compared with patients in group B. Our study reveals the importance of diet and insulin resistance in acne pathogenesis, and underlines the possible use of metformin and diet as possible adjuvant therapy for male patients with acne.
authors.affiliation: Department of Clinical Medicine and Surgery, Section of Clinical Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fabbrocini
authors.affiliation: Department of Clinical Medicine and Surgery, Section of Clinical Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Izzo
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Faggiano
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Del Prete
authors.affiliation: Department of Clinical Medicine and Surgery, Section of Clinical Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Donnarumma
authors.affiliation: Department of Clinical Medicine and Surgery, Section of Clinical Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Marasca
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Marciello
authors.affiliation: Department of Medicine, Salerno, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Savastano
authors.affiliation: Department of Clinical Medicine and Surgery, Section of Clinical Dermatology, University of Naples Federico II, Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Monfrecola
authors.affiliation: Department of Molecular and Clinical Endocrinology and Oncology, University of Naples Federico II, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Colao
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D004038:Diet, Reducing; D005947:Glucose / Q000378:metabolism; D038321:Glycemic Index; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin; D005947:Glucose