title: Magnetic Hyperthermia Ablation of Tumors Using Injectable Fe₃O₄/Calcium Phosphate Cement.
abstract: In this work, we have developed an injectable and biodegradable material using CPC containing Fe3O4 nanoparticles for minimally invasive and efficiently magnetic hyperthermia ablation of tumors. When exposed to an alternating magnetic field, the MCPC could quickly generate heat. The temperature of PBS and the excised bovine liver increased with the MCPC weight, iron content, and time. The ablated liver tissue volume for 0.36 g of 10% MCPC was 0.2 ± 0.03, 1.01 ± 0.07, and 1.96 ± 0.19 cm(3), respectively, at the time point of 60, 180, and 300 s. In our in vivo experiment, the MCPC could be directly injected into the center of the tumors under the guidance of ultrasound imaging. The formed MCPC was well-restricted within the tumor tissues without leakage, and the tumors were completely ablated by 0.36 g of 10% injectable MCPC after 180 s of induction heating.
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Xu
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Jinshun
authors.initials: J
authors.lastname: Xu
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zuo
authors.affiliation: ‡State Key Laboratory of High-Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-Xi Road, Shanghai 200050, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: §Department of Forensic Medicine, Chongqing Medical University, Chongqing, 400000 PR China.
authors.forename: Minzhu
authors.initials: M
authors.lastname: Zhao
authors.affiliation: §Department of Forensic Medicine, Chongqing Medical University, Chongqing, 400000 PR China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Li
authors.affiliation: ∥Affiliated Stomatological Hospital of Chongqing Medical University,Chongqing, 400000 PR China.
authors.forename: Jinlin
authors.initials: J
authors.lastname: Song
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Hongyun
authors.initials: H
authors.lastname: Zhao
authors.affiliation: †Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 PR China.
authors.forename: Zhechuan
authors.initials: Z
authors.lastname: Mei
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D002417:Cattle; D006979:Hyperthermia, Induced / Q000379:methods*; D007267:Injections; D008099:Liver / Q000473:pathology; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D019047:Phantoms, Imaging; D013817:Thermography
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D058185:Magnetite Nanoparticles; C020243:calcium phosphate
keywords: biodegradable; calcium phosphate cement; injectable; magnetic hyperthermia ablation; tumor