title: High intensity focused ultrasound ablation for submucosal fibroids: A comparison between type I and type II.
abstract: OBJECTIVE
  The aim of this study was to compare high-intensity focused ultrasound (HIFU) treatment for type I and type II submucosal fibroids.
  
  
  METHODS
  From October 2011 to October 2013, 55 patients with submucosal fibroids were enrolled in this study. Based on submucosal fibroid classification, 27 patients were grouped as type I submucosal fibroids, and 28 patients were classified as type II submucosal fibroids. All patients received HIFU treatment and completed 1-, 6-, and 12-month follow-ups. Adverse effects were recorded.
  
  
  RESULTS
  There were no significant differences in the baseline characteristics between the two groups (p > 0.05). Using similar sonication power, sonication time, and acoustic energy, the non-perfused volume (NPV) ratio was 83.0 ± 17.3% in the type I group, and 92.0 ± 9.5% in the type II group. All the patients tolerated the procedure well, and no serious adverse events occurred. During the follow-up intervals, the treated fibroids shrank and fibroid-related symptoms were relieved. No other reinterventional procedures were performed during the follow-up period.
  
  
  CONCLUSIONS
  Based on our results with a small number of subjects, HIFU is suitable for both type I and type II submucosal fibroids. It seems that type II submucosal fibroids are more sensitive to HIFU ablation. Future studies with larger sample sizes and longer follow-up times to investigate the long-term results, including long-term symptom relief, pregnancy outcomes, and the recurrence rate as well as the reintervention rate are needed.
authors.affiliation: a Department of Ultrasound , Huanggang Central Hospital , Huanggang City , Hubei , China .
authors.forename: Bin
authors.initials: B
authors.lastname: Xie
authors.affiliation: b State Key Laboratory of Ultrasound Engineering in Medicine , Chongqing Medical University , Chongqing , China , and.|c Department of Obstetrics and Gynecology , Suining Central Hospital , Sichuan , China.
authors.forename: Cai
authors.initials: C
authors.lastname: Zhang
authors.affiliation: b State Key Laboratory of Ultrasound Engineering in Medicine , Chongqing Medical University , Chongqing , China , and.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Xiong
authors.affiliation: c Department of Obstetrics and Gynecology , Suining Central Hospital , Sichuan , China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: b State Key Laboratory of Ultrasound Engineering in Medicine , Chongqing Medical University , Chongqing , China , and.|c Department of Obstetrics and Gynecology , Suining Central Hospital , Sichuan , China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Huang
authors.affiliation: b State Key Laboratory of Ultrasound Engineering in Medicine , Chongqing Medical University , Chongqing , China , and.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000009:adverse effects; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D008875:Middle Aged; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000601:surgery*
keywords: Adverse effects; efficacy; high intensity focused ultrasound (HIFU); submucosal fibroid