title: Spatial Analysis of Multiple Sclerosis Disease in Tehran Metropolitan Zone, Iran, 2001-2012.
abstract: BACKGROUND
  Multiple Sclerosis (MS) is a disease with high disabling disorders and considerable social and economic impacts. This study was conducted to analyze the spatial distribution of MS disease in Tehran, Iran during 2001-2012.
  
  
  METHODS
  The existing information in the MS patients' medical files who had registered in Iranian MS Society (IMSS), located in Tehran office, was used for analysis. The relationship between diseases incidences in 22 zones of Tehran based on estimated socio-economic status (SES) of each zone was evaluated. High and low clustering approach was used in order to investigate the disease's distribution pattern meanwhile, Getis Ord's Gi test and Hot Spot analysis approach has been used to detect high risk zones of the disease.
  
  
  RESULTS
  A total of 6027 MS patients were registered between 2001- 2012 which 4580 (%75.99) were women. During the study period, zone number 6 figured as the most high risk zone for the disease (P<0.1). A heterogeneous distribution was shown for the disease. Cumulative incidence of the disease in northern zones (101.73 per 100,000 inhabitants) was two times more of Southern zones (53.79 per 100,000 inhabitants). There seems to be a direct linear relationship between estimated incidence rate of the disease in each zones with the level of SES (P<0.001).
  
  
  CONCLUSIONS
  Heterogeneous geographical distribution of MS and its higher estimated incidence for northern zones in Tehran may be because of higher SES and other factors in mentioned zones. It is recommended to consider the surveillance with long-term and cost-effective interventional strategies along with disease in high risk zones.
authors.affiliation: 1. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of MedicalSciences , Tehran, Iran.
authors.forename: Mahbubeh
authors.initials: M
authors.lastname: Saei
authors.affiliation: 1. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of MedicalSciences , Tehran, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Holakouie-Naieni
authors.affiliation: 2. Dept. of Epidemiology, Pasteur Institute of Iran , Tehran, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Mostafavi
authors.affiliation: 3. Sina MS Research Center, Dept. of Neurology, Sina Hospital, Tehran University of Medical Sciences , Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
authors.affiliation: 1. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of MedicalSciences , Tehran, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Mahmoodi
authors.affiliation: 1. Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of MedicalSciences , Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Mansournia
authors.affiliation: 4. Dept. of Geography and Urban Planning, School of Geography, University of Tehran , Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Hosseini
keywords: Geographic information system (GIS); Multiple sclerosis; Spatial analysis