title: DUB-ling down on B-cell malignancies.
abstract: In this issue of Blood, Peterson et al demonstrate that inhibition of both Usp9x and Usp24 results in efficient degradation of Mcl-1, induction of apoptosis, and inhibition of tumor growth in B-cell malignancies.
authors.affiliation: EMORY UNIVERSITY.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Boise
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003487:Cyanoacrylates / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy*; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy*; D011725:Pyridines / Q000494:pharmacology*; D043222:Ubiquitin Thiolesterase / Q000037:antagonists & inhibitors*
chemical_list: D003487:Cyanoacrylates; D004791:Enzyme Inhibitors; D011725:Pyridines; D043222:Ubiquitin Thiolesterase