title: Anti-hyperalgesic and Anti-inflammatory Activity of Alternanthera Maritima Extract and 2″-O-α-L-rhamnopyranosylvitexin in Mice.
abstract: Alternanthera maritima are used in Brazilian popular medicine for the treatment of inflammatory and infectious diseases. Species of Alternanthera have demonstrated biological activities in previous scientific studies. The aim of this study was to determine whether the ethanol extract of the aerial parts of A. maritima (EEAM) and the isolated compound 2″-O-α-L-rhamnopyranosyl-vitexin inhibit mechanical hyperalgesia and parameters of inflammation in mice. The oral administration of EEAM significantly inhibited carrageenan (Cg)-induced paw edema and reduced leukocyte migration into the pleural cavity. 2″-O-α-L-rhamnopyranosylvitexin significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. Both EEAM and 2″-O-α-L-rhamnopyranosylvitexin significantly prevented the Cg-induced hyperalgesia. Local administration of 2″-O-α-L-rhamnopyranosylvitexin significantly prevented the Cg- and tumor necrosis factor (TNF)-induced hyperalgesia. In conclusion, this study demonstrated that EEAM is an anti-inflammatory and anti-hyperalgesic agent, and the results suggested that 2″-O-α-L-rhamnopyranosylvitexin is responsible for the effects of EEAM and the mechanism involves the TNF pathway.
authors.affiliation: College of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil.
authors.forename: Diana Figuereido
authors.initials: DF
authors.lastname: de Santana Aquino
authors.affiliation: College of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Piccinelli
authors.affiliation: College of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil.
authors.forename: Fabíola Lacerda Pires
authors.initials: FL
authors.lastname: Soares
authors.affiliation: Department of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, SP, Brazil.
authors.forename: Arielle Cristina
authors.initials: AC
authors.lastname: Arena
authors.affiliation: Institute of Biology, Department of Plant Biology, PPG BTPB, and PPG BV, University of Campinas (UNICAMP), 13083-970, Campinas, São Paulo, Brazil.
authors.forename: Marcos José
authors.initials: MJ
authors.lastname: Salvador
authors.affiliation: College of Health Science, Federal University of Grande Dourados, Dourados, 79825-070, MS, Brazil. candida2005@gmail.com.
authors.forename: Candida Aparecida Leite
authors.initials: CA
authors.lastname: Kassuya
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D047310:Apigenin / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D006930:Hyperalgesia / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D007980:Levodopa; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D010998:Pleurisy / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D004187:Disaccharides; D047309:Flavones; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007980:Levodopa; D047310:Apigenin; D002351:Carrageenan; C000609876:2''-O-rhamnopyranosylvitexin
keywords: 2″-O-α-L-rhamnopyranosyl-vitexin; alternanthera maritima; amaranthaceae; hyperalgesia; inflammation