title: Recent progress in understanding the molecular mechanisms of radioresistance in Deinococcus bacteria.
abstract: The deleterious effects of ionizing radiation are a major concern of the modern world. In the last decades, outstanding interest has been given to developing new therapeutic tools designed for protection against the toxic effects of ionizing radiation. Deinococcus spp. are among the most radioresistant organisms on Earth, being able to survive extreme doses of radiation, 1000-fold higher than most vertebrates. The molecular mechanisms underlying DNA repair and biomolecular protection, which are responsible for the remarkable radioresistance of Deinococcus bacteria, have been a debatable subject for the last 60 years. This paper is focused on the most recent findings regarding the molecular background of radioresistance and on Deinococcus bacteria response to oxidative stress. Novel proteins and genes involved in the highly regulated DNA repair processes, and enzymatic and non- enzymatic antioxidant systems are presented. In addition, a recently proposed mechanism that may contribute to oxidative damage protection in Deinococcus bacteria is discussed. A better understanding of these molecular mechanisms may draw future perspectives for counteracting radiation-related toxicity.
authors.affiliation: Department of Industrial Drugs and Pharmaceutical Biotechnology, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6, Traian Vuia Str., 020956, Bucharest, Romania, alexandra.mntn@gmail.com.
authors.forename: Alexandra- Cristina
authors.initials: A
authors.lastname: Munteanu
authors.forename: Valentina
authors.initials: V
authors.lastname: Uivarosi
authors.forename: Adrian
authors.initials: A
authors.lastname: Andries
mesh_terms: D004260:DNA Repair / Q000502:physiology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D034301:Deinococcus / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D011836:Radiation Tolerance / Q000502:physiology*
chemical_list: D004269:DNA, Bacterial