title: [Cystatin C as a mortality predictor in a hypertensive population in Extremadura, Spain].
abstract: OBJECTIVE
  Cystatin C has proven to be a useful parameter to evaluate renal and cardiovascular risk. Nevertheless, there are scanty reports on the utility of this test in the Spanish population. We performed a survey in a group of patients followed up in Primary Care settings.
  
  
  METHODS
  Prospective follow up of Primary Care attended patients recruited in 2008 and the first half of 2009. The sample included 142 subjects (mean age 64.2±14.6 years, 59.2% men). In all cases, cystatin C was determined and glomerular filtration rate (GFR) was estimated through the Hoek formula. Serum creatinine was also quantified as it was GFR estimated using CKD-EPI equation. The primary objective was a combination of death and major cardiovascular events incidence.
  
  
  RESULTS
  There were 29 events registered (4 of them were deaths) and 9 non cardiovascular deaths. The odds ratio for the primary objective was 5.74 for the last quartile of cystatin C distribution (>1mg/l) (P=.002), while it was 6.44 for cystatin C derived GFR (P=.008) and 5.59 for CKD-EPI estimated GFR (P=.002, Mantel-Haenszel test).
  
  
  CONCLUSIONS
  Cystatin C showed a good association with general mortality and the incidence of cardiovascular events in the Spanish population. Nevertheless, it was not better than the observed relationship with GFR, estimated from creatinine.
authors.affiliation: Centro de Salud José María Alvarez, Don Benito, Badajoz, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Garcia Gallego
authors.affiliation: Cátedra de Riesgo Cardiovascular, Facultad de Medicina, Universidad de Salamanca, Salamanca, España. Electronic address: nrrobles@yahoo.es.
authors.forename: Nicolás Roberto
authors.initials: NR
authors.lastname: Robles
authors.affiliation: Centro de Salud José María Alvarez, Don Benito, Badajoz, España.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Matias Orozco
authors.affiliation: Centro de Salud José María Alvarez, Don Benito, Badajoz, España.
authors.forename: Candido
authors.initials: C
authors.lastname: Mena
authors.affiliation: Servicio de Bioquímica Clínica, Hospital Don Benito-Villanueva de la Serena, Don Benito, Badajoz, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cidoncha
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000401:mortality; D002423:Cause of Death; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D015994:Incidence; D008875:Middle Aged; D009026:Mortality; D011379:Prognosis; D011446:Prospective Studies; D012306:Risk; D013030:Spain / Q000453:epidemiology
chemical_list: D055316:Cystatin C; D003404:Creatinine
keywords: Cardiovascular risk; Cistatina C; Cystatin C; Filtrado glomerular; Función renal; Glomerular filtration rate; Renal function; Riesgo cardiovascular