title: Pancytopenia and cutaneous cryptococcosis as an indicator disease of acquired immune deficiency syndrome.
abstract: We present a case of pancytopenia and cutaneous cryptococcosis in a young girl with no complaints of fever, headache and vomiting. Fine-needle aspiration cytology and further investigation for pancytopenia revealed presence of Cryptococcus in skin and bone marrow aspirates. Fungal cultures of the skin aspirates, blood and bone marrow confirmed cryptococcal infection. Counselling and human immunodeficiency virus (HIV) test revealed the status of the patient to be retropositive. Although meningitis is the commonest manifestation of cryptococcosis among HIV-infected patients, rare cutaneous manifestation with pancytopenia but with no meningeal signs indicate the HIV status in an endemic area of penicilliosis, Manipur.
authors.affiliation: Department of Microbiology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
authors.forename: R
authors.initials: R
authors.lastname: Khuraijam
authors.forename: P
authors.initials: P
authors.lastname: Lungran
authors.forename: K
authors.initials: K
authors.lastname: Yoihenba
authors.forename: R S
authors.initials: RS
authors.lastname: Laishram
authors.forename: P
authors.initials: P
authors.lastname: Pukhrambam
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D044963:Biopsy, Fine-Needle; D001769:Blood / Q000382:microbiology; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000175:diagnosis* / Q000473:pathology*; D003454:Cryptococcus / Q000302:isolation & purification; D003881:Dermatomycoses / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D005260:Female; D006801:Humans; D010198:Pancytopenia / Q000175:diagnosis* / Q000473:pathology*; D055815:Young Adult