title: Clinical effect of biapenem on nursing and healthcare-associated pneumonia (NHCAP).
abstract: The clinical effect of Biapenem (BIPM) on Nursing and Healthcare-associated pneumonia (NHCAP) was evaluated. One hundred and three NHCAP patients (Group B: 52 patients, Group C: 51 patients) to whom BIPM was administered were included in this study. Clinical effect, bacteriological effect, and adverse events were examined. Results revealed efficacy in 45 of 52 patients (efficacy rate: 86.5%) of NHCAP Group B, and 43 of 51 patients (efficacy rate: 84.3%) of NHCAP Group C, 88 of 103 patients (efficacy rate: 85.4%) as a whole. As for bacteriological effect, 10 (76.9%) of 13 Pseudomonas aeruginosa strains, 9 (90.0%) of 10 Klebsiella pneumoniae strains, 7 (87.5%) of 8 methicillin-sensitive Staphlococcus aureus strains, and 7 (100%) of 7 Streptococcus pneumonia strains were eradicated. As a whole, 38 (80.9%) of 47 strains were eradicated. Adverse events included drug fever and drug eruption in one patient each, and abnormal laboratory findings, including mild hepatic dysfunction in 18 patients and mild renal dysfunction in 5 patients. Based on the above, it was concluded that BIPM shows excellent clinical effect on NHCAP with fewer adverse events.
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan. Electronic address: n.okimoto@med.kawasaki-m.ac.jp.
authors.forename: Niro
authors.initials: N
authors.lastname: Okimoto
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawai
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katoh
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.
authors.forename: Toshikiyo
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Kurihara
authors.affiliation: Department of Genera Internal Medicine 1, Kawasaki Hospital, Kawasaki Medical School, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyashita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology; D011552:Pseudomonas Infections / Q000150:complications / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012720:Severity of Illness Index; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy*; D013845:Thienamycins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000890:Anti-Infective Agents; D013845:Thienamycins; C065257:biapenem
keywords: Biapenem; Carbapenms; Nursing and healthcare-associated pneumonia