title: [EPHX1 Tyr113His polymorphism contributes to hepatocellular carcinoma risk: evidfnce from a meta-analysis].
abstract: To clarify the association between microsomal epoxide hydrolase gene (EPHX1) Tyr113His polymorphism and hepatocellular carcinoma (HCC) risk, a meta-analysis was performed. Overall, EPHX1 Tyr113His polymorphism was associated with increased risk of HCC. Subgroup analyses by status of Hardy-Weinberg equilibrium (HWE) in controls further confirmed this association. Through a literature search, 119 relevant records were identified, and 17 individual case-control studies from 13 publications were finally included, involving a total of 1,480 HCC cases and 2,564 controls. In subgroup analyses, increased associations were found in Asians, Caucasians, hepatitis B virus (HBV)- dominant areas, hepatitis C virus (HCV)-dominant areas, high-rate areas of HCC, and medium-rate areas of HCC, but not in Africans and low-rate areas of HCC, respectively. This meta-analysis suggests that EPHX1 Tyr113His polymorphism contributes to HCC risk.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: J X
authors.initials: JX
authors.lastname: Zhai
authors.forename: L M
authors.initials: LM
authors.lastname: Zhang
authors.forename: D W
authors.initials: DW
authors.lastname: Liu
authors.forename: X H
authors.initials: XH
authors.lastname: Liu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D004851:Epoxide Hydrolases / Q000235:genetics* / Q000378:metabolism; D006639:Histidine / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014443:Tyrosine / Q000235:genetics / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D014443:Tyrosine; D006639:Histidine; D004851:Epoxide Hydrolases; C522330:EPHX1 protein, human