title: Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury.
abstract: Ischemia-reperfusion (I/R) injury is one of the major causes of high morbidity, disability, and mortality in the world. I/R injury remains a complicated and unresolved situation in clinical practice, especially in the field of solid organ transplantation. Hydrogen sulfide (H2S) is the third gaseous signaling molecule and plays a broad range of physiological and pathophysiological roles in mammals. H2S could protect against I/R injury in many organs and tissues, such as heart, liver, kidney, brain, intestine, stomach, hind-limb, lung, and retina. The goal of this review is to highlight recent findings regarding the role of H2S in I/R injury. In this review, we present the production and metabolism of H2S and further discuss the effect and mechanism of H2S in I/R injury.
authors.affiliation: Medical College of Henan University, Kaifeng, Henan 475004, China.
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Medical College of Henan University, Kaifeng, Henan 475004, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Medical College of Henan University, Kaifeng, Henan 475004, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Neurology, Institute of Neurological Disorders, The First Affiliated Hospital of Henan University, Kaifeng 475001, China.
authors.forename: Mengzhou
authors.initials: M
authors.lastname: Xue
authors.affiliation: Medical College of Henan University, Kaifeng, Henan 475004, China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Ji
authors.affiliation: Medical College of Henan University, Kaifeng, Henan 475004, China.
authors.forename: Yanzhang
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity
chemical_list: D006862:Hydrogen Sulfide