title: Live birth after autograft of ovarian tissue cryopreserved during childhood.
abstract: Ovarian insufficiency is a major long-term adverse event, following the administration of a myeloablative conditioning regimen, and occurring in >80% of children and adolescents receiving such treatment for malignant or non-malignant disease. Cryopreservation of ovarian tissue is currently offered to preserve the fertility of these young patients. At least 35 live births have been reported after transplantation of cryopreserved ovarian tissue in adult patients, but the procedure remains unproven for ovarian tissue harvested at a prepubertal or pubertal age. We report here the first live birth after autograft of cryopreserved ovarian tissue in a woman with primary ovarian failure after a myeloablative conditioning regimen as part of a hematopoietic stem cell transplantation performed for homozygous sickle-cell anemia at age 14 years. This first report of successful fertility restoration after the graft of ovarian tissue cryopreserved before menarche offers reassuring evidence for the feasibility of the procedure when performed during childhood.
authors.affiliation: Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium idemeest@ulb.ac.be.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Demeestere
authors.affiliation: Gynecology Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Simon
authors.affiliation: Department of Hematology-Oncology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
authors.forename: Laurence
authors.initials: L
authors.lastname: Dedeken
authors.affiliation: Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Present address: Instituto Marqués, Assisted Reproduction Service, Manuel Girona 33, MASIA, 08034 Barcelona, Spain.
authors.forename: Federica
authors.initials: F
authors.lastname: Moffa
authors.affiliation: Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium Present address: Nivelles Hospital, Rue Samiette, 1400 Nivelles, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Tsépélidis
authors.affiliation: Department of Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
authors.forename: Cecile
authors.initials: C
authors.lastname: Brachet
authors.affiliation: Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Fertility Clinic, Department of Obstetrics and Gynaecology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Delbaere
authors.affiliation: Research Laboratory on Human Reproduction, Faculty of Medicine, Université Libre de Bruxelles (ULB), Campus Erasme, CP636, 808 route de Lennik, 1070 Brussels, Belgium Department of Endocrinology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Devreker
authors.affiliation: Department of Hematology-Oncology, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), 1020 Brussels, Belgium.
authors.forename: Alina
authors.initials: A
authors.lastname: Ferster
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000628:therapy; D064592:Autografts / Q000637:transplantation*; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D050498:Live Birth; D019653:Myeloablative Agonists / Q000009:adverse effects; D010053:Ovary / Q000637:transplantation*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced; D014182:Transplantation, Autologous
chemical_list: D019653:Myeloablative Agonists
keywords: childhood; fertility preservation; live birth; ovarian tissue cryopreservation; transplantation