title: Intravenous GPIIb/IIIa Inhibitor for Secondary Prevention of Shunt Thrombosis in a Pediatric Patient.
abstract: Thrombosis occurs after aortopulmonary shunting in children despite the use of heparin and oral antiplatelet agents. We describe the use of an intravenous antiplatelet agent for secondary prevention of shunt thrombosis without adverse events. Platelet mapping was used to monitor the effects and demonstrated the rapid onset of platelet inhibition.
authors.affiliation: Department of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts. Electronic address: sitaram.emani@cardio.chboston.org.
authors.forename: Sirisha
authors.initials: S
authors.lastname: Emani
authors.affiliation: Department of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Kaza
authors.affiliation: Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Melvin
authors.initials: M
authors.lastname: Almodovar
authors.affiliation: Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Ravi
authors.initials: R
authors.lastname: Thiagarajan
authors.affiliation: Department of Cardiovascular Surgery, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Sitaram M
authors.initials: SM
authors.lastname: Emani
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D011859:Radiography; D055502:Secondary Prevention / Q000379:methods*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex