title: Trends in perinatal deaths from 2010 to 2013 in the Guatemalan Western Highlands.
abstract: BACKGROUND
  While progress has been made in reducing neonatal mortality in Guatemala, stillbirth and maternal mortality rates remain high, especially among the indigenous populations, which have among the highest adverse pregnancy-related mortality rates in Guatemala.
  
  
  METHODS
  We conducted a prospective study in the Western Highlands of Guatemala from 2010 through 2013, enrolling women during pregnancy with follow-up through 42-days postpartum. All pregnant women were identified and enrolled by study staff in the clusters in the Chimaltenango region for which we had 4 years of data. Enrolment usually occurred during the antenatal period; women were also visited following delivery and 42-days postpartum to collect outcomes. Measures of antenatal and delivery care were also obtained.
  
  
  RESULTS
  Approximately four thousand women were enrolled annually (3,869 in 2010 to 4,570 in 2013). The stillbirth rate decreased significantly, from 22.0 per 1000 births (95% CI 16.6, 29.0) in 2010 to 16.7 (95% CI 13.5, 20.6) in 2013 (p-value 0.0223). The perinatal mortality rate decreased from 43.9 per 1,000 births (95% CI 36.0, 53.6) to 31.6 (95% CI 27.2, 36.7) (p-value 0.0003). The 28-day neonatal mortality rate decreased from 28.9 per 1000 live births (95% CI 25.2, 33.2) to 21.7 (95% CI 17.5, 26.9), p-value 0.0004. The maternal mortality rate was 134 per 100,000 in 2010 vs. 113 per 100,000 in 2013. Over the same period, hospital birth rates increased from 30.0 to 50.3%.
  
  
  CONCLUSIONS
  In a relatively short time period, significant improvements in neonatal, fetal and perinatal mortality were noted in an area of Guatemala with a history of poor pregnancy outcomes. These changes were temporally related to major increases in hospital-based delivery with skilled birth attendants, as well as improvements in the quality of delivery care, neonatal care, and prenatal care.
authors.forename: Ana
authors.initials: A
authors.lastname: Garces
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Mcclure
authors.forename: K
authors.initials: K
authors.lastname: Hambidge
authors.forename: Nancy F
authors.initials: NF
authors.lastname: Krebs
authors.forename: Lester
authors.initials: L
authors.lastname: Figueroa
authors.forename: Marta
authors.initials: M
authors.lastname: Aguilar
authors.forename: Janet L
authors.initials: JL
authors.lastname: Moore
authors.forename: Robert L
authors.initials: RL
authors.lastname: Goldenberg
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006166:Guatemala / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007226:Infant Mortality / Q000639:trends; D007231:Infant, Newborn; D008427:Maternal Health Services / Q000592:standards; D008428:Maternal Mortality / Q000639:trends; D054238:Perinatal Mortality / Q000639:trends*; D011247:Pregnancy; D011446:Prospective Studies; D011787:Quality of Health Care; D012042:Registries; D050497:Stillbirth / Q000453:epidemiology; D055815:Young Adult