title: Chronic consumption of an inositol-enriched carob extract improves postprandial glycaemia and insulin sensitivity in healthy subjects: A randomized controlled trial.
abstract: Inositols are thought to be mediators of the insulin signalling pathway. We assessed the effects of inositols on glycaemic control in fasting and postprandial states and evaluated lipoprotein profile and LDL particle size in healthy population.
  
  
  
  A 12-week double-blind clinical trial was performed with forty healthy subjects administered either an inositol-enriched beverage (IEB) -containing 2.23 g of inositols in 250 ml- or a sucrose-sweetened beverage (SB) twice a day. Anthropometric measurements, fasting glucose levels, insulin and HOMA-IR index, lipoprotein profile and postprandial glucose concentrations (measured using the continuous glucose monitoring system (CGMS)) were recorded throughout the intervention period.
  
  
  
  Following the 12-week trial subjects receiving the IEB exhibited a significant decrease in insulin, HOMA-IR and Apo B and an increase in LDL particle size, whereas the SB group showed increases in BMI and fasting glucose concentration. Analysis of postprandial glucose levels at breakfast, lunch and dinner revealed a mean reduction of glucose of ≈14% and a significant reduction in the area under the curve at 24 h after consumption of the IEB.
  
  
  
  Our results show that chronic IEB supplementation induces a significant improvement in carbohydrated metabolism parameters in healthy subjects.
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain.
authors.forename: Celia
authors.initials: C
authors.lastname: Bañuls
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Rovira-Llopis
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Falcón
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Veses
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Department of Medicine, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Monzó
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain; Department of Physiology, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain.
authors.forename: Víctor M
authors.initials: VM
authors.lastname: Víctor
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; CIBER CB06/04/0071 Research Group, CIBER Hepatic and Digestive Diseases, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain. Electronic address: milagros.rocha@uv.es.
authors.forename: Milagros
authors.initials: M
authors.lastname: Rocha
authors.affiliation: Service of Endocrinology, University Hospital Dr. Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Avda. Gaspar Aguilar 90, 46017 Valencia, Spain; Institute of Health Research INCLIVA, Av Blasco Ibáñez 17, 46010 Valencia, Spain; Department of Medicine, Faculty of Medicine, University of Valencia, Av Blasco Ibáñez 13, 46010 Valencia, Spain. Electronic address: hernandez_antmij@gva.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Hernández-Mijares
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control*; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D007294:Inositol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007333:Insulin Resistance; D053419:Lipoproteins, IDL / Q000097:blood / Q000737:chemistry; D008297:Male; D018670:Monitoring, Ambulatory; D010316:Particle Size; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D019518:Postprandial Period; D012639:Seeds / Q000737:chemistry; D013030:Spain / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D053419:Lipoproteins, IDL; D010936:Plant Extracts; C021730:pinitol; D007294:Inositol
keywords: Carob pod extract; Continuous glucose monitoring system; Healthy subjects; Inositols; LDL particle size; Pinitol