title: Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia.
abstract: Asphyxia during delivery produces long-term deficits in brain development. We investigated the neuroprotective effects of marine collagen peptides (MCPs), isolated from Chum Salmon skin by enzymatic hydrolysis, on male rats with perinatal asphyxia (PA). PA was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a water bath for 15 min. Caesarean-delivered pups were used as controls. PA rats were intragastrically administered with 0.33 g/kg, 1.0 g/kg and 3.0 g/kg body weight MCPs from postnatal day 0 (PND 0) till the age of 90-days. Behavioral tests were carried out at PND21, PND 28 and PND 90. The results indicated that MCPs facilitated early body weight gain of the PA pups, however had little effects on early physiological development. Behavioral tests revealed that MCPs facilitated long-term learning and memory of the pups with PA through reducing oxidative damage and acetylcholinesterase (AChE) activity in the brain, and increasing hippocampus phosphorylated cAMP-response element binding protein (p-CREB) and brain derived neurotrophic factor (BDNF) expression.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. bmuliyong58@126.com.
authors.forename: Linlin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. monydwh@163.com.
authors.forename: Wenhong
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. zhaojie0410@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. xuyajun@bjmu.edu.cn.|Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, No. 38 Xue Yuan Road, Hai Dian District, Beijing 100191, China. xuyajun@bjmu.edu.cn.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001238:Asphyxia Neonatorum / Q000188:drug therapy* / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003094:Collagen / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D017685:Oncorhynchus keta / Q000378:metabolism; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000737:chemistry; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents; D010455:Peptides; D003094:Collagen
keywords: marine collagen peptides; neurobehavioral development; perinatal asphyxia