title: [Galectins, a class of unconventional lectins].
abstract: Galectins constitute a family of soluble animal lectins defined by their evolutionary conserved carbohydrate recognition domain and their affinity for β-galactosides containing glycoconjugates. Each galectin is characterized by a specific spatio-temporal distribution and a unique set of ligands and molecular partners. Interestingly, galectins are found both extracellularly and intracellularly and modulate various cellular processes. Knock-out mutant mice for galectins-1, 3 or 7 are viable but display a wide range of defects under various stress conditions. Indeed, galectins are multifunctional proteins involved in cell-cell and cell-extracellular matrix interactions, organization of membrane domains, cell signalling and also in intracellular trafficking, apoptosis, regulation of cell cycle. Galectins represent potential therapeutic targets, especially in the context of cancer and inflammatory diseases.
authors.affiliation: Institut Jacques Monod, UMR 7592 CNRS, université Paris-Diderot, équipe morphogenèse, homéostasie et pathologies, 15, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors.forename: Tamara
authors.initials: T
authors.lastname: Advedissian
authors.affiliation: Institut Jacques Monod, UMR 7592 CNRS, université Paris-Diderot, équipe morphogenèse, homéostasie et pathologies, 15, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors.forename: Frédérique
authors.initials: F
authors.lastname: Deshayes
authors.affiliation: Institut Jacques Monod, UMR 7592 CNRS, université Paris-Diderot, équipe morphogenèse, homéostasie et pathologies, 15, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Poirier
authors.affiliation: Équipe ingénierie moléculaire et glycobiologie, UMR CNRS 6286, unité fonctionnalité et ingénierie des protéines, faculté des sciences et techniques de Nantes, 2, rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Grandjean
authors.affiliation: Institut Jacques Monod, UMR 7592 CNRS, université Paris-Diderot, équipe morphogenèse, homéostasie et pathologies, 15, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors.forename: Mireille
authors.initials: M
authors.lastname: Viguier
mesh_terms: D056704:Adaptive Immunity / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001665:Binding Sites; D002448:Cell Adhesion / Q000502:physiology; D002468:Cell Physiological Phenomena; D015195:Drug Design; D019143:Evolution, Molecular; D037161:Galectins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007239:Infections / Q000276:immunology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy; D005810:Multigene Family; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy; D011134:Polysaccharides / Q000378:metabolism; D017434:Protein Structure, Tertiary; D012326:RNA Splicing / Q000502:physiology; D013347:Subcellular Fractions / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D037161:Galectins; D011134:Polysaccharides