title: Relation of stem cell markers ALDH1 and CD44 with clinicopathological factors in urothelial carcinomas of urinary bladder.
abstract: Molecular studies are ongoing in regards to superficial urothelial carcinoma of the bladder (UCB) either to define targeted therapy or to better select aggressive therapy candidates and also to delineate the outcome of the disease. In this study, we aimed to present the impact of ALDH1 and CD44 as stem cell markers in tumorigenesis and their prognostic value in urothelial carcinoma. We investigated ALDH1 and CD44 immunohistochemically in paraffin-embedded material of 125 non-muscle-invasive (NMI) cases in 163 UCB patients. In the NMI-UCB subgroup, we found ALDH1 to be significantly correlated with all poor prognostic factors, including high stage (≥pT2), high grade, recurrence and progression development and poor survey (P=0.001) in contrast to CD44 expression (P>0.05). Although ALDH1 expression had a good correlation with a poor clinical course of UCB, it could be used as a molecular marker to determine the best treatment strategy and could contribute to the development of targeted therapies.
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Senol
authors.affiliation: Department of Urology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Asif
authors.initials: A
authors.lastname: Yildırım
authors.affiliation: Department of Medical Genetics, Istanbul Medeniyet University, Faculty of Medicine Istanbul, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akalin
authors.affiliation: Department of Urology, Istanbul Fatih Sultan Mehmet Training and Research Hospital Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Uruç
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Bengü
authors.initials: B
authors.lastname: Çobanoğlu
authors.affiliation: Department of Medical Genetics, Istanbul Medeniyet University, Faculty of Medicine Istanbul, Turkey.
authors.forename: Sarenur
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Ceyran
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Duygu
authors.initials: D
authors.lastname: Kösemetin
authors.affiliation: Department of Pathology, Istanbul Dr. Lütfi Kırdar Kartal Research and Training Hospital Istanbul, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Ece
authors.affiliation: Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Aydın
keywords: ALDH1; CD44; bladder carcinoma; prognostic value