title: Complete Endoscopic Thyroidectomy via Oral Vestibular Approach Versus Areola Approach for Treatment of Thyroid Diseases.
abstract: BACKGROUND
  Natural orifice translumenal endoscopic surgery (NOTES(®); American Society for Gastrointestinal Endoscopy [Oak Brook, IL] and Society of American Gastrointestinal and Endoscopic Surgeons [Los Angeles, CA]) is gaining interest because it allows operations without skin incisions. The aim of this study was to evaluate the feasibility, safety, and cosmetic results of endoscopic thyroidectomy via the oral vestibular approach (ETOVA) compared with endoscopic thyroidectomy via the areola approach (ETAA) in patients with thyroid diseases.
  
  
  METHODS
  Eighty-two patients with thyroid diseases were randomized to receive either ETOVA (n=41) or ETAA (n=41). Perioperative and follow-up data were assessed.
  
  
  RESULTS
  The surgery was completed in all cases, and all patients were followed up for at least 1 year. There were no differences between the two groups in operation time, blood loss, or postoperative hospital stay. Respective pain scores were 1.7 versus 2.1 and 0.6 versus 0.8 on Days 1 and 3, respectively, postoperatively. The white blood cell counts and C-reactive protein levels were not significantly different between the two groups. Complications were the same in both groups. Oral incision scars were invisible in the ETOVA group. Rates of skin traction sensation on the surgical field were lower in the ETOVA group than in the ETAA group at 3 and 6 months postoperatively (53.7% versus 80.5% and 24.4% versus 46.3%, respectively). The respective satisfaction score was 9.61 versus 9.22 (P=.021). No recurrent cases were observed in the study.
  
  
  CONCLUSIONS
  Both the ETOVA and the ETAA procedures are feasible for thyroid diseases. The ETOVA eliminated skin incision scars and gained better cosmetic results in the short-term follow-ups, and the trauma was the same between the two approaches. However, more cases and longer-term follow-ups are needed for confirmation.
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Jingge
authors.initials: J
authors.lastname: Yang
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Cunchuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Jinyi
authors.initials: J
authors.lastname: Li
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Wah
authors.initials: W
authors.lastname: Yang
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Guo
authors.initials: G
authors.lastname: Cao
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Hong-Meng
authors.initials: HM
authors.lastname: Wong
authors.affiliation: 1 Department of General Surgery, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Hening
authors.initials: H
authors.lastname: Zhai
authors.affiliation: 2 Department of Stomatology, First Affiliated Hospital of Jinan University , Guangzhou, China .
authors.forename: Weijun
authors.initials: W
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000601:surgery; D002921:Cicatrix; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D061646:Operative Time; D013959:Thyroid Diseases / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult