title: Association of pneumococcal conjugate vaccination with rates of ventilation tube insertion in Denmark: population-based register study.
abstract: OBJECTIVE
  To examine if the introduction of pneumococcal conjugate vaccine (PCV) in Denmark was associated with a decrease in the rate of ventilation tube (VT) insertions performed by office-based practising ear, nose and throat (ENT) specialists.
  
  
  METHODS
  Population-based register study based on prospectively collected data.
  
  
  METHODS
  Central Denmark Region. Data on VT insertions performed by any office-based practising ENT specialist in the region were collected from the National Health Service Registry.
  
  
  METHODS
  All children below the age of 2 years with a first-time VT insertion from 2001 through 2011.
  
  
  METHODS
  Age-stratified and gender-stratified standardised incidence rates of first-time VT insertion, and incidence rate ratio for PCV period 2008-2011 compared with pre-PCV period 2001-2007.
  
  
  RESULTS
  The annual incidence rate of first-time VT insertion in small children increased steadily from 64/1000 person-years in 2001 to 100/1000 person-years in 2011. The incidence rate ratio was 1.27 (95% CI 1.24 to 1.30) in the PCV period compared with the pre-PCV period.
  
  
  CONCLUSIONS
  The introduction of PCV into the Danish childhood immunisation programme in 2007 was not associated with a subsequent decrease in the rate of VT insertions among children below the age of 2 years. Instead, the rate continued to rise, as before the introduction of PCV.
  
  
  BACKGROUND
  Danish Data Protection Agency: 2007-58-0010.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Christina
authors.initials: C
authors.lastname: Groth
authors.affiliation: Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Reimar W
authors.initials: RW
authors.lastname: Thomsen
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus C, Denmark.
authors.forename: Therese
authors.initials: T
authors.lastname: Ovesen
mesh_terms: D000367:Age Factors; D003718:Denmark; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008876:Middle Ear Ventilation / Q000706:statistics & numerical data*; D010033:Otitis Media / Q000628:therapy*; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D011446:Prospective Studies; D012042:Registries; D012737:Sex Factors; D014611:Vaccination; D018074:Vaccines, Conjugate / Q000008:administration & dosage
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate
keywords: EPIDEMIOLOGY; PRIMARY CARE