title: Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.
abstract: Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
authors.forename: Clementina
authors.initials: C
authors.lastname: Mesaros
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Worth
authors.affiliation: 2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|5Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
authors.forename: Nathaniel W
authors.initials: NW
authors.lastname: Snyder
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|4A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
authors.forename: Melpo
authors.initials: M
authors.lastname: Christofidou-Solomidou
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|4A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
authors.forename: Anil
authors.initials: A
authors.lastname: Vachani
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|4A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Albelda
authors.affiliation: 1Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.|2Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Blair
mesh_terms: D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D010994:Pleura / Q000187:drug effects / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001194:Asbestos