title: Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale.
abstract: In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Rungatscher
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Tessari
authors.affiliation: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Stranieri
authors.affiliation: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Solani
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Linardi
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Milani
authors.affiliation: Section of General Pathology, Department of Pathology and Diagnostics, University of Verona, 37126 Verona, Italy.
authors.forename: Alessio
authors.initials: A
authors.lastname: Montresor
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, 37126 Verona, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Merigo
authors.affiliation: Department of Neurological and Movement Sciences, University of Verona, 37126 Verona, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Salvetti
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Tiziano
authors.initials: T
authors.lastname: Menon
authors.affiliation: Department of Surgery, Division of Cardiac Surgery, University of Verona, 37126 Verona, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0001-5371-5761
authors.initials: G
authors.lastname: Faggian
mesh_terms: D000818:Animals; D005112:Extracorporeal Circulation; D007249:Inflammation / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism*; D023421:Models, Animal; D010106:Oxygenators