title: Lipid profile response to weight loss program in overweight and obese patient is related with gender and age.
abstract: BACKGROUND
  The risk of developing cardiovascular disease (CVD) increases with age, however CVD is markedly higher in men than in no-menopausal women. There are few interventions where compare the different effects to lose weight on lipid profile between men and women.
  
  
  OBJECTIVE
  The aim of this study was to compare the response on the lipid profile by gender after a weight loss program, and determine whether there are differences by age group.
  
  
  METHODS
  One hundred eighty (96 women and 84 men) overweight and obese participants (BMI 25-34.9 kg/m2) aged 18-50 years were randomised into treatment groups. The intervention period was 22 weeks (in all cases 3 times/wk of training for 22 weeks and 2 weeks for pre and post evaluation). All subjects followed a hypocaloric diet (25-30% less energy intake). Energy intake, body composition) and blood lipid profile were recorded at baseline and after of treatment.
  
  
  RESULTS
  The response of HDL varied between men and women (p = 0.001). While in women it decreased (HDL: -2.94%, p = 0.02), HDL was elevated in men (HDL: 5% p = 0.02). After intervention men achieved decrease significantly LDL values a 6.65% more than women (p = 0.01). For TG concentrations there were significant differences between men and women in baseline however, only men had a significant chance in post-training measured (p = 0.001). TC showed significant differences between men and women in baseline (p = 0.013). After intervention, men and women showed a significant decreased to TC (p = 0.01).
  
  
  CONCLUSIONS
  Men achieve a positive greater change on lipid profile than women. In addition, the favorable lipid profile response decreases with increasing age.
authors.affiliation: Healthy Sciences Faculty. Camilo José Cela University. (Villanueva de la Cañada), Madrid. EFISAF Research Group. Technical University of Madrid, Spain.. blancaromeromoraleda@gmail.com.
authors.forename: Blanca
authors.initials: B
authors.lastname: Romero-Moraleda
authors.affiliation: Department of Health and Human Performance. School of Physical Activity and Sport Sciences. Technical University of Madrid, Madrid. EFISAF Research Group. Technical University of Madrid, Spain.. blancaromeromoraleda@gmail.com.
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Peinado Lozano
authors.affiliation: Department of Health and Human Performance. School of Physical Activity and Sport Sciences. Technical University of Madrid, Madrid.. blancaromeromoraleda@gmail.com.
authors.forename: Esther
authors.initials: E
authors.lastname: Morencos Martínez
authors.affiliation: Nutrition Department. University Hospital La Paz, Madrid.. blancaromeromoraleda@gmail.com.
authors.forename: Bricia
authors.initials: B
authors.lastname: López-Plaza
authors.affiliation: Nutrition Department. University Hospital La Paz, Madrid.. blancaromeromoraleda@gmail.com.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez Candela
authors.affiliation: Department of Health and Human Performance. School of Physical Activity and Sport Sciences. Technical University of Madrid, Madrid. EFISAF Research Group. Technical University of Madrid, Spain.. blancaromeromoraleda@gmail.com.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Calderón Montero
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000178:diet therapy / Q000628:therapy*; D050177:Overweight / Q000097:blood* / Q000178:diet therapy / Q000628:therapy*; D010806:Physical Education and Training; D012737:Sex Factors; D015431:Weight Loss; D061217:Weight Reduction Programs; D055815:Young Adult
chemical_list: D008055:Lipids