title: Frequency of Human Papillumavirus among Women with High-Grade Squamous Intraepithelial Lesions and Invasive Cervical Cancer Attending Shahid Beheshti University of Medical Sciences Clinics, Tehran, Iran.
abstract: BACKGROUND
  The previous studies reported some information about prevalence release of high-risk HPV types in HSIL or cervical cancer globally and in Iran, however, this information is not enough for final judgment about vaccination against HPV or any screening program. The aim of the present study was to assess the HPV type distribution in HSIL and ICC specimens of women attending Shahid Beheshti University of Medical Sciences teaching hospitals, Tehran, Iran for treatment during 10 years.
  
  
  METHODS
  This retrospective- descriptive study evaluated the HPV type distribution of pathologic specimens of Iranian women with invasive cervical cancer (ICC) and high-grade squamous cell intraepithelial lesions (HSIL). Formalin-fixed tumor biopsies that were retrieved from women presenting with histological confirmation for ICC and 17 pathologic confirmation for HSIL specimens.
  
  
  RESULTS
  The most frequently identified HPV type 16 among both groups, women with invasive cervical cancer (4-2.18%) and women with High Grade Squamous Intraepithelial Lesion (29.41%), followed by HPV18, HPV31 and 26. HPV16 and / or 18 accounted for 82.2% of all infected samples.
  
  
  CONCLUSIONS
  The dominance of HPV16 over other high-risk types might be even higher than in a region with low HPV exposure. However, there was no strong evidence for any judgment that show to the policy makers; which one is cost-effectiveness and feasibility for cervical cancer prevention in Iran, vaccination, screening or both? More population based study and national meta-analysis needed for better understanding of HPV prevalence and HPV DNA patterns in Iran.
authors.affiliation: 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Khodakarami
authors.affiliation: 2. Dept. of Pathology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Afshin
authors.initials: A
authors.lastname: Moradi
authors.affiliation: 3. Dept. of Oncology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Mirzaei
authors.affiliation: 4. Dept. of Obstetrics/Gynecology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Farah
authors.initials: F
authors.lastname: Farzaneh
authors.affiliation: 5. Dept., of Epidemiology, Health & Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Yavari
authors.affiliation: 1. Cancer Research Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
authors.forename: Mohamad Esmaeil
authors.initials: ME
authors.lastname: Akbari
keywords: Human papillomavirus; Invasive cervical cancer; Iran; Squamous intraepithelial lesions