title: Real-Time High-Resolution Tandem Mass Spectrometry Identifies Furan Derivatives in Exhaled Breath.
abstract: The identification of chemical compounds in exhaled human breath is promising in the search for new biomakers of diseases. However, the analytical techniques used nowadays are not capable of achieving a robust identification, especially in real-time analysis. In this work, we show that real-time high-resolution tandem mass spectrometry (HRMS/MS) is suitable for the identification of biomarkers in exhaled breath. Using this approach, we identified a number of furan derivatives, compounds found in the exhalome whose nature and origin are not yet clearly understood. It is also shown that the combination of HRMS/MS with UHPLC allowed not only the identification of the furan derivatives but also the proper separation of their isomeric forms.
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Zurich CH-8093, Switzerland.
authors.forename: Diego
authors.initials: D
authors.lastname: García-Gómez
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Zurich CH-8093, Switzerland.
authors.forename: Lukas
authors.initials: L
authors.lastname: Bregy
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Zurich CH-8093, Switzerland.
authors.forename: César
authors.initials: C
authors.lastname: Barrios-Collado
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Zurich CH-8093, Switzerland.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Vidal-de-Miguel
authors.affiliation: Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Zurich CH-8093, Switzerland.
authors.forename: Renato
authors.initials: R
authors.lastname: Zenobi
mesh_terms: D001944:Breath Tests; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000032:analysis*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D005663:Furans