title: Bartonella quintana Aortitis in a Man with AIDS, Diagnosed by Needle Biopsy and 16S rRNA Gene Amplification.
abstract: A man with newly diagnosed AIDS presented with months of back pain and fever. Computed tomography (CT) results demonstrated aortitis with periaortic tissue thickening. DNA amplification of biopsy tissue revealed Bartonella quintana, and Bartonella serologies were subsequently noted to be positive. The patient improved with prolonged doxycycline and rifabutin treatment. This case illustrates how molecular techniques are increasingly important in diagnosing Bartonella infections.
authors.affiliation: Department of Medicine, Division of HIV/AIDS, University of California, San Francisco, San Francisco, California, USA sulggi.lee@ucsf.edu.
authors.forename: Sulggi A
authors.initials: SA
authors.lastname: Lee
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Sara K
authors.initials: SK
authors.lastname: Plett
authors.affiliation: Department of Medicine, Division of HIV/AIDS, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Luetkemeyer
authors.affiliation: Microbial Pathogenesis and Host Defense Program and Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Gina M
authors.initials: GM
authors.lastname: Borgo
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Ohliger
authors.affiliation: Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Miles B
authors.initials: MB
authors.lastname: Conrad
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA Department of Microbiology, University of Washington, Seattle, Washington, USA.
authors.forename: Brad T
authors.initials: BT
authors.lastname: Cookson
authors.affiliation: Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
authors.forename: Dhruba J
authors.initials: DJ
authors.lastname: Sengupta
authors.affiliation: Microbial Pathogenesis and Host Defense Program and Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Koehler
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D001025:Aortitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D018413:Bartonella quintana / Q000302:isolation & purification*; D001707:Biopsy, Needle; D016000:Cluster Analysis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D004318:Doxycycline / Q000627:therapeutic use; D020459:Genes, rRNA; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017828:Rifabutin / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014205:Trench Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D017828:Rifabutin; D004318:Doxycycline