title: [Enamel: a unique self-assembling in mineral world].
abstract: Enamel is a unique tissue in vertebrates, acellular, formed on a labile scaffolding matrix and hypermineralized. The ameloblasts are epithelial cells in charge of amelogenesis. They secrete a number of matrix proteins degraded by enzymes during enamel mineralization. This ordered cellular and extracellular events imply that any genetic or environmental perturbation will produce indelible and recognizable defects. The specificity of defects will indicate the affected cellular process. Thus, depending on the specificity of alterations, the teratogenic event can be retrospectively established. Advances in the field allow to use enamel defects as diagnostic tools for molecular disorders. The multifunctionality of enamel peptides is presently identified from their chemical roles in mineralization to cell signaling, constituting a source of concrete innovations in regenerative medicine.
authors.affiliation: Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France.
authors.forename: Guilhem
authors.initials: G
authors.lastname: Lignon
authors.affiliation: Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France - Centre de référence des malformations rares de la face et de la cavité buccale, CRMR-MAFACE, hôpital Rothschild, APHP, Paris, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: de la Dure-Molla
authors.affiliation: Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Dessombz
authors.affiliation: Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France - Centre de référence des malformations rares de la face et de la cavité buccale, CRMR-MAFACE, hôpital Rothschild, APHP, Paris, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Berdal
authors.affiliation: Laboratoire de physiopathologie orale moléculaire, Inserm UMRS 1138, centre de recherche des Cordeliers, université Paris Diderot-Paris 7, université Pierre et Marie Curie-Paris 6, université Paris Descartes-Paris 5, 15-21, rue de l'École de Médecine, 75270 Paris cedex 06, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Babajko
mesh_terms: D000565:Ameloblasts / Q000166:cytology / Q000378:metabolism; D000566:Amelogenesis / Q000502:physiology; D000818:Animals; D003743:Dental Enamel / Q000737:chemistry / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D003744:Dental Enamel Hypoplasia / Q000235:genetics / Q000503:physiopathology; D003746:Dental Enamel Proteins / Q000502:physiology; D017886:Durapatite / Q000737:chemistry; D004658:Enamel Organ / Q000502:physiology; D009050:Fluorosis, Dental / Q000209:etiology; D006801:Humans; D025202:Molecular Diagnostic Techniques; D054118:Nanospheres; D010447:Peptide Hydrolases / Q000502:physiology; D013723:Teratogens / Q000494:pharmacology; D014074:Tooth Calcification / Q000502:physiology
chemical_list: D003746:Dental Enamel Proteins; D013723:Teratogens; C109069:enamel matrix proteins; D017886:Durapatite; D010447:Peptide Hydrolases