title: Neuromyelitis optica with linear enhancement of corpus callosum in brain magnetic resonance imaging with contrast: a case report.
abstract: BACKGROUND
  Neuromyelitis optica is a demyelinating disease of the central nervous system with various patterns of brain lesions. Corpus callosum may be involved in both multiple sclerosis and neuromyelitis optica. Previous case reports have demonstrated that callosal lesions in neuromyelitis optica are usually large and edematous and have a heterogeneous intensity showing a "marbled pattern" in the acute phase. Their size and intensity may reduce with time or disappear in the chronic stages.
  
  
  METHODS
  In this report, we describe a case of a 25-year-old Caucasian man with neuromyelitis optica who presented clinically with optic neuritis and myelitis. His brain magnetic resonance imaging demonstrated linear enhancement of the corpus callosum. Brain images with contrast agent added also showed linear ependymal layer enhancement of the lateral ventricles, which has been reported in this disease previously.
  
  
  CONCLUSIONS
  Linear enhancement of corpus callosum in magnetic resonance imaging with contrast agent could help in diagnosing neuromyelitis optica and differentiating it from other demyelinating disease, especially multiple sclerosis.
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran. msahari@sina.tums.ac.ir.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sahraian
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran. Abdorrezamoghadasi@gmail.com.
authors.forename: Abdorreza Naser
authors.initials: AN
authors.lastname: Moghadasi
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran. Mahsa.owji@gmail.com.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Owji
authors.affiliation: MS Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran. hodanaghshineh@yahoo.com.
authors.forename: Hoda
authors.initials: H
authors.lastname: Naghshineh
authors.affiliation: Department of Neurology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71103, USA. aminag@lsuhsc.edu.
authors.forename: Alireza
authors.initials: A
authors.lastname: Minagar
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001931:Brain Mapping; D003287:Contrast Media; D003337:Corpus Callosum / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D003287:Contrast Media; D001379:Azathioprine