title: Basophils exhibit antibacterial activity through extracellular trap formation.
abstract: Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report, we provide evidence that, in spite of an apparent lack of phagocytic activity, basophils can kill bacteria through BET formation.
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Yousefi
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Morshed
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Amini
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Stojkov
authors.affiliation: Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Simon
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: von Gunten
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Kaufmann
authors.affiliation: Institute of Pharmacology, University of Bern, Bern, Switzerland.
authors.forename: H-U
authors.initials: HU
authors.lastname: Simon
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D001491:Basophils / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology*; D065206:Extracellular Traps / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000382:microbiology; D056747:Immunomodulation; D051379:Mice; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology
keywords: basophil extracellular trap; basophils; extracellular bacterial killing; innate immunity; phagocytosis