title: Green Tea and Bone Marrow Transplantation: From Antioxidant Activity to Enzymatic and Multidrug-resistance Modulation.
abstract: Epigallocatechin-3-gallate (EGCG), the main flavonoid of green tea (GT), could play an active role in the prevention of oxidative-stress-related diseases, such as hematologic malignancies. Some effects of EGCG are not imputable to antioxidant activity, but involve modulation of antioxidant enzymes and uric acid (UA) levels. The latter is the major factor responsible of the plasma non-enzymatic antioxidant capacity (NEAC). However, hyperuricemia is a frequent clinical feature caused by tumor lysis syndrome or cyclosporine side effects, both before and after bone marrow transplantation (BMT). Besides this, food-drug interactions could be associated with GT consumption and could have clinical implications. The molecular mechanisms involved in the redox and drug metabolizing/transporting pathways were discussed, with particular reference to the potential role of GT and EGCG in BMT. Moreover, on reviewing data on NEAC, isoprostanes, uric acid, and various enzymes from human studies on GT, its extract, or EGCG, an increase in NEAC, without effect on isoprostanes, and contrasting results on UA and enzymes were observed. Currently, few and contrasting available evidences suggest caution for GT consumption in BMT patients and more studies are needed to better understand the potential impact of EGCG on oxidative stress and metabolizing/transporting systems.
authors.affiliation: a Department of Physiology and Pharmacology "V. Erspamer" , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Peluso
authors.affiliation: a Department of Physiology and Pharmacology "V. Erspamer" , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Maura
authors.initials: M
authors.lastname: Palmery
authors.affiliation: a Department of Physiology and Pharmacology "V. Erspamer" , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Annabella
authors.initials: A
authors.lastname: Vitalone
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D016026:Bone Marrow Transplantation; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018565:Food-Drug Interactions; D006801:Humans; D013662:Tea / Q000737:chemistry*; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D013662:Tea; D014527:Uric Acid; D002392:Catechin; C045651:epigallocatechin gallate
keywords: Green tea; antioxidant; bone marrow transplantation; hyperuricemia; multidrug resistance