title: Closing the gap between brain banks and proteomics to advance the study of neurodegenerative diseases.
abstract: Neurodegenerative diseases (NDs), such as Alzheimer's disease and Parkinson's disease, are among the most debilitating neurological disorders, and as life expectancy rises quickly around the world, the scientific and clinical challenges of dealing with them will also increase dramatically, putting increased pressure on the biomedical community to come up with innovative solutions for the understanding, diagnosis, and treatment of these conditions. Despite several decades of intensive research, there is still little that can be done to prevent, cure, or even slow down the progression of NDs in most patients. There is an urgent need to develop new lines of basic and applied research that can be quickly translated into clinical application. One way to do this is to apply the tools of proteomics to well-characterized samples of human brain tissue, but a closer partnership must still be forged between proteomic scientists, brain banks, and clinicians to explore the maximum potential of this approach. Here, we analyze the challenges and potential benefits of using human brain tissue for proteomics research toward NDs.
authors.affiliation: Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil.|Discipline of Geriatrics, University of Sao Paulo Medical School, Sao Paulo, Brazil.
authors.forename: Renata Elaine
authors.initials: RE
authors.lastname: Paraizo Leite
authors.affiliation: Physiopathology in Aging Lab/Brazilian Aging Brain Study Group-LIM22, University of Sao Paulo Medical School, Sao Paulo, Brazil.|Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA.
authors.forename: Lea
authors.initials: L
authors.lastname: Tenenholz Grinberg
mesh_terms: D001921:Brain / Q000378:metabolism*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology*; D040901:Proteomics / Q000379:methods*
keywords: Brain bank; Human brain; Neurodegenerative diseases; Neuroproteomics