title: Draft genome sequences of three NDM-1-producing Enterobacteriaceae species isolated from Brazil.
abstract: The emergence of multidrug-resistant Enterobacteriaceae strains producing carbapenemases, such as NDM-1, has become a major public health issue due to a high dissemination capacity and limited treatment options. Here we describe the draft genome of three NDM-1-producing isolates: Providencia rettgeri (CCBH11880), Enterobacter hormaechei subsp. oharae (CCBH10892) and Klebsiella pneumoniae (CCBH13327), isolated in Brazil. Besides blaNDM-1, resistance genes to aminoglycosides [aadA1, aadA2, aac(6')-Ib-cr] and quinolones (qnrA1, qnrB4) were observed which contributed to the multidrug resistance profile. The element ISAba125 was found associated to the blaNDM-1 gene in all strains.
authors.affiliation: Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Polyana Silva
authors.initials: PS
authors.lastname: Pereira
authors.affiliation: Departamento de Bioquímica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Rodolpho Mattos
authors.initials: RM
authors.lastname: Albano
authors.affiliation: Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Marise Dutra
authors.initials: MD
authors.lastname: Asensi
authors.affiliation: Laboratório de Pesquisa em Infecção Hospitalar, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Ana Paula D'Alincourt
authors.initials: AP
authors.lastname: Carvalho-Assef
mesh_terms: D001483:Base Sequence; D001938:Brazil; D024881:Drug Resistance, Bacterial / Q000235:genetics; D004754:Enterobacter / Q000201:enzymology / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D011532:Providencia / Q000201:enzymology / Q000235:genetics*; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases; C552864:beta-lactamase NDM-1