title: Minimal invasive treatments for liver malignancies.
abstract: Minimal invasive therapies have proved useful in the management of primary and secondary hepatic malignancies. The most relevant aspects of all these therapies are their minimal toxicity profiles and highly effective tumor responses without affecting the normal hepatic parenchyma. These unique characteristics coupled with their minimally invasive nature provide an attractive therapeutic option for patients who previously may have had few alternatives. Combination of these therapies might extend indications to bring curative treatment to a wider selected population. The results of various ongoing combination trials of intraarterial therapies with targeted therapies are awaited to further improve survival in this patient group. This review focuses on the application of ablative and intra-arterial therapies in the management of hepatocellular carcinoma and hepatic colorectal metastasis.
authors.affiliation: European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. Electronic address: franco.orsi@ieo.it.
authors.forename: Franco
authors.initials: F
authors.lastname: Orsi
authors.affiliation: European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Varano
mesh_terms: D000818:Animals; D003452:Cryosurgery; D053672:Electrochemotherapy; D004621:Embolization, Therapeutic; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D019060:Minimally Invasive Surgical Procedures
keywords: Ablative therapies; HIFU; Hepatic colorectal metastasis; Liver malignancy; Minimally invasive treatment