title: Performance evaluation of developed polysulfone membrane hemodiafilters, ABH-F and ABH-P, in post- and pre-dilution hemodiafiltration.
abstract: ABH-F and ABH-P have been developed for hemodiafiltration (HDF) therapy. In this study, we evaluated the solute removal characteristics of the hemodiafilters in a bovine blood in vitro study. The hemodiafilters were examined for 120 min at various filtration flow rates (Q F) (31.2-250 mL/min) under a constant blood flow rate of 250 mL/min and constant dialysate flow rates of 500/250 mL/min in pre-dilution HDF (pre-HDF) and post-dilution HDF (post-HDF). Creatinine clearance in pre-HDF was approximately 85% of that in post-HDF because it was removed by molecular diffusion dominantly. The initial clearances of β2-microglobulin and α1-microglobulin increased with Q F and these values slightly and steeply decreased with time due to membrane fouling. Under a same Q F of 62.5 mL/min, higher clearance values in post-HDF were obtained compared with those in pre-HDF. All clearance values of ABH-P were higher than those of ABH-F under the same Q F. It seems that the ABH-P has a larger pore size of membrane than that in ABH-F. The creatinine and α1-microglobulin clearance values were obtained as highest at post-Q F62.5, the β2-microglobulin clearance values and transmembrane pressure were obtained as highest at pre-Q F250. Large solute clearances such as α1-microglobulin and albumin decreased with time in all HDF experiments. Time decay of large solute clearance values was observed in the HDF modality that had a higher clearance of the solute at 5 min later after the start of experiment.
authors.affiliation: Department of Clinical Engineering, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. sakiyama@twmu.ac.jp.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Sakiyama
authors.affiliation: Department of Clinical Engineering, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Yamamoto
authors.affiliation: Department of Clinical Engineering, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Isamu
authors.initials: I
authors.lastname: Ishimori
authors.affiliation: Department of Clinical Engineering, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: Department of Blood Purification, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
authors.affiliation: Department of Clinical Engineering, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Mineshima
mesh_terms: D000418:Albumins / Q000378:metabolism; D000510:Alpha-Globulins / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003404:Creatinine / Q000097:blood; D015314:Dialysis Solutions; D017583:Hemodiafiltration / Q000295:instrumentation*; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D000418:Albumins; D000510:Alpha-Globulins; D015314:Dialysis Solutions; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C016001:alpha-1-microglobulin; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700; D003404:Creatinine
keywords: Clearance; Hemodiafilter; Post-dilution HDF; Pre-dilution HDF; TMP