title: Anhedonia in combat veterans with penetrating head injury.
abstract: Anhedonia is a common symptom following traumatic brain injury. The neural basis of anhedonia is poorly understood, but believed to involve disturbed reward processing, rather than the loss of sense of pleasure. This analysis was undertaken to determine if injury to specific regions of prefrontal cortex (PFC) result in anhedonia. A CT-based lesion analysis was undertaken in 192 participants of the Vietnam Head Injury Study, most with penetrating head injury. Participants were divided into left and right ventrolateral prefrontal, bilateral ventromedial prefrontal, and other injury locations. Anhedonia was measured by self-report in each group using the four-item anhedonia subscale score of the Beck Depression Inventory-II. Individuals with right ventrolateral injury reported greater severity of anhedonia compared to those with injury in the left ventrolateral region. These findings support an association between injury in the right ventrolateral PFC and anhedonia.
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Lewis
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Krueger
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.|West London Mental Health Trust and Imperial College, London, UK.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Raymont
authors.affiliation: Expert Image Analysis, Potomac, MD, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Solomon
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Knutson
authors.affiliation: Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
authors.forename: Aron K
authors.initials: AK
authors.lastname: Barbey
authors.affiliation: Draper Laboratories, Cambridge, MA, USA.
authors.forename: Joshua C
authors.initials: JC
authors.lastname: Poore
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. WassermannE@ninds.nih.gov.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Wassermann
authors.affiliation: National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.|Rehabilitation Institute of Chicago, Chicago, IL, USA.|Northwestern University, Chicago, IL, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Grafman
mesh_terms: D059445:Anhedonia; D015331:Cohort Studies; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000453:epidemiology; D005500:Follow-Up Studies; D020197:Head Injuries, Penetrating / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000293:injuries*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000453:epidemiology; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000000981:diagnostic imaging / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014728:Veterans; D047829:Vietnam Conflict
keywords: Anhedonia; Depression; Motivational anhedonia; Reward; Traumatic brain injury; Ventrolateral prefrontal cortex