title: Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case-control study of gc globulin and bronchopulmonary dysplasia.
abstract: OBJECTIVE
  The pathophysiologies of bronchopulmonary dysplasia (BPD) are inflammation, infection, tissue damage, angiogenesis defects and genetic susceptibility. Because of the role of the vitamin D binding protein (Gc globulin) on these factors, we investigated the relationship between Gc globulin polymorphisms and BPD.
  
  
  METHODS
  This case-control study was performed with 160 neonates (⩽32 gestational ages, ⩽1500 g). PCR DNA sequence analyses were used for GC gene rs4588 and rs7041 single-nucleotide polymorphisms.
  
  
  RESULTS
  In the univariate analyses, it was observed that Gc2 was the only variant that was protective against BPD (Odd ratio (OR)=0.47, 95% coinfidence interval (CI)=0.24 to 0.89, P=0.020). In the multivariate analyses, Gc2 decreased the risk of disease (OR=0.15, 95% CI=0.029 to 0.79, P=0.026) independent of gestational age, birth weight, 5-min Appearance, Pulse, Grimace, Activity, and Respiration scores, respiratory distress syndrome and sepsis.
  
  
  CONCLUSIONS
  The Gc2 variant was, after adjusting for confounders, associated with a decrease in the frequency of BPD. Our study adds Gc globulin to the list of candidate genes that potentially contribute to the etiology of the disease.
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Neonatology Unit, Istanbul, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Serce Pehlevan
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Neonatology Unit, Istanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Karatekin
authors.affiliation: Burc Genetic Diagnosis Center, Istanbul, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Koksal
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Neonatology Unit, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Benzer
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Neonatology Unit, Istanbul, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Gursoy
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Pediatric Cardiology Unit, Istanbul, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Yavuz
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Neonatology Unit, Istanbul, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Ovali
mesh_terms: D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014421:Turkey; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D014809:Vitamin D-Binding Protein