title: First recovery of Rasamsonia argillacea species complex isolated in adolescent patient with cystic fibrosis in Slovenia--case report and review of literature.
abstract: We report the isolation of the emerging fungal pathogen Rasamsonia aegroticola, which belongs Rasamsonia argillacea species complex, from a respiratory sample of a patient with cystic fibrosis. This filamentous fungus, resembling members of a Penicillium and Paecilomyces spp., was identified by morphology and confirmed by DNA sequence analysis. Susceptibility pattern showed high minimal inhibitory concentration of voriconazole and amphotericin B but low minimal inhibitory concentration of caspofungin, micafungin and itraconazole.
authors.affiliation: Faculty of Medicine, Institute of microbiology and immunology, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Tadeja
authors.initials: T
authors.lastname: Matos
authors.affiliation: Faculty of Medicine, Institute of microbiology and immunology, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Tjaša
authors.initials: T
authors.lastname: Cerar
authors.affiliation: Unit of Pulmonary Diseases, Division of Paediatrics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Marina
authors.initials: M
authors.lastname: Praprotnik
authors.affiliation: Unit of Pulmonary Diseases, Division of Paediatrics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Uroš
authors.initials: U
authors.lastname: Krivec
authors.affiliation: Faculty of Medicine, Institute of microbiology and immunology, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Mateja
authors.initials: M
authors.lastname: Pirš
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000077336:Caspofungin; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology*; D054714:Echinocandins / Q000494:pharmacology; D032641:Eurotiales / Q000166:cytology / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009181:Mycoses / Q000150:complications* / Q000382:microbiology*; D010614:Pharynx / Q000382:microbiology; D017422:Sequence Analysis, DNA; D017524:Slovenia; D065819:Voriconazole / Q000494:pharmacology; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000666:Amphotericin B; D000077336:Caspofungin; D065819:Voriconazole
keywords: Rasamsonia (Geosmithia) argillacea species complex; Rasamsonia aegroticola; cystic fibrosis; emerging fungal pathogen