title: Optimized core-shell Au@Ag nanoparticles for label-free Raman determination of trace Rhodamine B with cancer risk in food product.
abstract: A simple and reliable method based on surface-enhanced Raman scattering (SERS) with a portable Raman system is described for sensitive determination of trace levels of Rhodamine B (RB) in hot sauce samples. The sodium salt of phytic acid (IP6) stabilized Au@Ag core-shell bimetallic nanoparticles are constructed and used as SERS substrate, yielding high Raman enhancement of RB. The limit of detection for RB in water is 5 nM (2 ppb), which is below China Exit and Entry Inspection and Quarantine Bureau's tolerance level of 5 ppb. Also, the proposed easy assay of IP6-Au@Ag NPs combining with portable Raman system could be applied for on-site monitoring RB in hot sauce.
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China. Electronic address: gxy2012@shnu.edu.cn.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Guo
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Shuyue
authors.initials: S
authors.lastname: Fu
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Tianxi
authors.initials: T
authors.lastname: Yang
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wen
authors.affiliation: The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors and Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China. Electronic address: haifengyang@yahoo.com.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Yang
mesh_terms: D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000737:chemistry / Q000209:etiology*; D012235:Rhodamines / Q000737:chemistry*; D012307:Risk Factors; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D012235:Rhodamines; D012834:Silver; D006046:Gold; C029773:rhodamine B
keywords: Ag–Au bimetal; Core–shell nanostructure; Raman probe; Rhodamine B