title: Circulating tumour cells in patients with lung cancer undergoing endobronchial cryotherapy.
abstract: Early diagnosis of lung cancer still poses a major issue, with a large proportion of patients diagnosed at late stages. Therapeutic options and treatment remain limited in these patients. In most cases only palliative therapies are available to alleviate any severe symptoms. Endobronchial cryotherapy (EC) is one form of palliative treatment offered to patients with obstructive airway tumours. Although successful, the impact on circulating tumour cell (CTCs) spread has not been investigated in detail. This study recruited 20 patients awaiting EC treatment. Baseline and post EC blood samples were analysed for presence of CTCs. Results showed an increase in CTCs following EC in 75% of patients. Significant increases were noticeable in some cases. Although EC is a well-accepted modality of treatment to alleviate symptoms, it may lead to an increase in CTCs, which in turn may have implications for tumour dissemination and metastatic spread.
authors.affiliation: Department of Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Dimple
authors.initials: D
authors.lastname: Chudasama
authors.affiliation: Department of Pathology, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rice
authors.affiliation: Department of Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, United Kingdom.
authors.forename: Gopal
authors.initials: G
authors.lastname: Soppa
authors.affiliation: Department of Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, United Kingdom. Electronic address: V.Anikin@rbht.nhs.uk.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Anikin
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000601:surgery; D002452:Cell Count; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods*; D017679:Cryotherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D010166:Palliative Care / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies
keywords: Circulating tumour cells; Endobronchial cryotherapy; Endobronchial tumours; ScreenCell