title: Quality and Outcomes of Treatment of Hypercalcemia of Malignancy.
abstract: Using a nationwide database, 4,874 patients with hypercalcemia of malignancy were identified. The in-hospital mortality rate was 6.8%. Overall, 1,971 (40.4%) patients received pamidronate and 1,399 (28.7%) received zoledronic acid during hospitalization. Calcitonin was utilized in 1,337 (27.4%) patients while glucocorticoids were administered to 1,311 (26.9%). Use of contraindicated medications was noted in 136 (2.8%) patients who received thiazide diuretics and 12 (0.2%) who received lithium. Tumor site, presence of bone metastases, and severity of illness were predictors of treatment. There was no association between treatment with bisphosphonates, calcitonin, or glucocorticoids and morbidity or mortality.
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.|b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Wright
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.|b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.|d Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , USA .
authors.forename: Ana I
authors.initials: AI
authors.lastname: Tergas
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.|d Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , USA .
authors.forename: Cande V
authors.initials: CV
authors.lastname: Ananth
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.|b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Burke
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.|b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.
authors.forename: June Y
authors.initials: JY
authors.lastname: Hou
authors.affiliation: a Department of Obstetrics and Gynecology , Columbia University , New York , USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.|d Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , USA .|e Department of Medicine, College of Physicians and Surgeons , Columbia University , New York , USA.
authors.forename: Alfred I
authors.initials: AI
authors.lastname: Neugut
authors.affiliation: d Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , USA .
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Richards
authors.affiliation: b Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons , Columbia University , New York , USA.|c New York Presbyterian Hospital , New York , USA.|d Department of Epidemiology, Mailman School of Public Health , Columbia University , New York , USA .|e Department of Medicine, College of Physicians and Surgeons , Columbia University , New York , USA.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary; D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D000077268:Pamidronate; D011787:Quality of Health Care; D016896:Treatment Outcome; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D004232:Diuretics; D005938:Glucocorticoids; D007093:Imidazoles; D000077211:Zoledronic Acid; D002116:Calcitonin; D000077268:Pamidronate
keywords: Calcium; Hypercalcemia; Malignancy