title: Long-Term Outcome of IPAA in Patients Presenting with Fulminant Ulcerative Colitis: A Matched Cohort Study.
abstract: BACKGROUND
  Studies reveal that ileal pouch-anal anastomosis (IPAA) has long-term success. These reports, however, use well-selected cohorts and exclude patients presenting with fulminant colitis (FC). Herein, we aimed to characterize long-term functional outcomes in patients with fulminant ulcerative colitis (UC) undergoing IPAA.
  
  
  METHODS
  A prospective database identified patients who underwent IPAA between 1998 and 2008. Patients with FC and chronic UC were matched by age, gender, date of surgery, and follow-up duration. Clinical and laboratory parameters, immunomodulator use at the time of surgery, and functional outcomes were compared.
  
  
  RESULTS
  Forty patients with FC and 73 patients with chronic UC were identified. Preoperative albumin, hemoglobin, leukocyte count, and steroid dose were significantly different for those with FC. Average survey follow-up was 5.2 years for FC and 6.7 years for chronic UC patients. Functional outcomes were not significantly different. The 3-year fistula-free rate was 91.4 versus 98.6 % and the 3-year stricture-free rate was 79.3 versus 87.2 % for FC versus chronic UC patients, respectively.
  
  
  CONCLUSIONS
  Patients undergoing colectomy for FC secondary to UC have similar long-term functional outcomes after IPAA despite significantly worse presentation. This study confirms that IPAA is an appropriate and durable treatment for patients with FC.
authors.affiliation: Division of Subspecialty General Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA, fasen.geoffrey@mayo.edu.
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Fasen
authors.forename: T K
authors.initials: TK
authors.lastname: Pandian
authors.forename: Emily S
authors.initials: ES
authors.lastname: Pavey
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Dozois
authors.forename: Sarah Y
authors.initials: SY
authors.lastname: Boostrom
mesh_terms: D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects*; D003251:Constriction, Pathologic / Q000209:etiology; D003672:Defecation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects*; D012003:Rectal Fistula / Q000209:etiology*; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult