title: [Effects of mono-, poly- and composite probiotics on the ulceration caused by restraint stress].
abstract: It was studied the effect of probiotic strains of Bifidobacterium animalis VKL, Bifidobacterium animalis VKB and Lactobacillus casei IMVB-7280, and their mixtures on erosive and ulcerative lesions of the gastric mucosa (GM) of rats. GM was induced by water-immersion restraint stress. It was found that investigated probiotics did not have gastroprotective properties under a single and seven-day prophylactic administration. However, multiprobiotics (polyprobiotic Bifidobacterium animalis VKL and Bifidobacterium animalis VKB and composite probiotic Bifidobacterium animalis VKL, Bifidobacterium animalis VKB and Lactobacillus casei IMVB-7280) reduced the erosive and ulcerative lesions and the intensity of bleeding in rat GM when given within 14 days. It was shown that one of the mechanisms of antiulcer preventive effect of the multistrain probiotics is the restoration of pro/antioxidant balance in the GM under the stress action. The obtained results show the effectiveness of poly- and composite probiotics in the gastric ulcer prevention.
authors.forename: O V
authors.initials: OV
authors.lastname: Virchenko
authors.forename: T M
authors.initials: TM
authors.lastname: Falalyeyeva
authors.forename: T V
authors.initials: TV
authors.lastname: Beregova
authors.forename: M Y
authors.initials: MY
authors.lastname: Spivak
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: O M
authors.initials: OM
authors.lastname: Demchenko
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D001644:Bifidobacterium / Q000502:physiology*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D006471:Gastrointestinal Hemorrhage / Q000178:diet therapy* / Q000209:etiology / Q000473:pathology; D007103:Immobilization / Q000009:adverse effects*; D007780:Lacticaseibacillus casei / Q000502:physiology*; D019936:Probiotics / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000178:diet therapy* / Q000209:etiology / Q000473:pathology; D013312:Stress, Physiological