title: Fibronectin glomerulopathy.
abstract: Fibronectin glomerulopathy occurs between the second and fifth decades of life in most patients, and it is known to be slowly progressive with mild proteinuria leading to kidney failure. The case of a 78-year-old woman with a rapid course of nephrotic syndrome due to fibronectin glomerulopathy is reported. She had proteinuria that rapidly increased to 6.8 g/day in a month and microscopic haematuria. A renal biopsy specimen showed lobular glomerulopathy and membranoproliferative glomerulonephritis-like lesions on light microscopy. There was scanty staining for immunoglobulins and complement. Electron microscopy revealed granular deposits with fibril formation. Immunohistochemistry of the fibronectin showed intense staining in the mesangium and peripheral loop. Therefore, this case was diagnosed as fibronectin glomerulopathy. The kidney function was rapidly decreasing, necessitating haemodialysis 2 months after renal biopsy. It is important to consider fibronectin glomerulopathy in the differential diagnosis of nephrotic syndrome in older people.
authors.affiliation: Department of Nephrology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Ikue
authors.initials: I
authors.lastname: Ishimoto
authors.affiliation: Department of Nephrology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Eisei
authors.initials: E
authors.lastname: Sohara
authors.affiliation: Department of Pathology, Graduate School of Medicine , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Eisaku
authors.initials: E
authors.lastname: Ito
authors.affiliation: Department of Nephrology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Okado
authors.affiliation: Department of Nephrology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Tatemitsu
authors.initials: T
authors.lastname: Rai
authors.affiliation: Department of Nephrology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University , Tokyo , Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uchida
keywords: fibronectin glomerulopathy; haemodialysis; nephrotic syndrome