title: Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst.
abstract: A one-pot two-step reaction (Knoevenagel condensation - reduction of the double bond) has been developed using calcium hydride as a reductant in the presence of a supported noble metal catalyst. The reaction between carbonyl compounds and active methylene compounds such as methylcyanoacetate, 1,3-dimethylbarbituric acid, dimedone and the more challenging dimethylmalonate, affords the corresponding monoalkylated products in moderate to good yields (up to 83%) with minimal reduction of the starting carbonyl compounds.
authors.affiliation: Equipe Catalyse Synthèse Environnement, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Université de Lyon, Université Claude Bernard-Lyon 1, Bâtiment Curien, 43 boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France. estelle.metay@univ-lyon1.fr.
authors.forename: Carole
authors.initials: C
authors.lastname: Guyon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Duclos
authors.forename: Marc
authors.initials: M
authors.lastname: Sutter
authors.forename: Estelle
authors.initials: E
authors.lastname: Métay
authors.forename: Marc
authors.initials: M
authors.lastname: Lemaire