title: A polyvinyl alcohol-functionalized sorbent for extraction and determination of aminoglycoside antibiotics in honey.
abstract: A novel highly hydrophilic sorbent simply prepared by coating polyvinyl alcohol (PVA) onto silica gel was used for extraction and determination of aminoglycoside antibiotics (AAs). The fabricated PVA coating is aimed to effectively protect core silica gel inside and offers good hydrophilic property. In combination of hydrophilic interaction chromatography tandem mass spectrometry, the performance of the sorbent was evaluated by selecting four model AAs (dihydrostreptomycin, streptomycin, kanamycin, spectinomycin). The sorbent was found to have effective adsorption ability to hydrophilic AAs, which was superior or comparable to those of commercial ones. Good recoveries (84-112%) of model AAs spiked in honey were obtained with good precision (<12.4%) and the limit of quantitation for the proposed method was in the range of 7.8-19.4ng/mL.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Shunli
authors.initials: S
authors.lastname: Ji
authors.affiliation: Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: zhangff@ecust.edu.cn.
authors.forename: Feifang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
mesh_terms: D000327:Adsorption; D000617:Aminoglycosides / Q000032:analysis* / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002845:Chromatography; D005504:Food Analysis / Q000295:instrumentation / Q000379:methods*; D006722:Honey / Q000032:analysis*; D057927:Hydrophobic and Hydrophilic Interactions; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D058428:Silica Gel / Q000737:chemistry; D053719:Tandem Mass Spectrometry
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D058428:Silica Gel; D011142:Polyvinyl Alcohol
keywords: Aminoglycoside antibiotics; HILIC; Honey; Polyvinyl alcohol; Sorbent