title: Maintenance periodontal therapy after systemic antibiotic and regenerative therapy of generalized aggressive periodontitis. A case report with 10-year follow-up.
abstract: Aggressive periodontitis (AgP) is an inflammatory disease characterized by rapid attachment loss and bone destruction. This case report presents the 10-year results in a subject with generalized AgP treated by a regenerative periodontal therapeutic approach and the adjunctive use of antibiotics, following a systematic maintenance periodontal therapy. The use of enamel matrix derivatives (EMD) and adjunctive antibiotic therapy to treat AgP yielded improvements in clinical parameters and radiographic bony fill. This combined therapeutic approach following a systematic supportive periodontal therapy supports the long-term maintenance of teeth with previous advanced periodontal defects, demonstrating successful stability after 10-years follow-up. Clinical Relevance: The combined treatment protocol using EMD plus adjunctive antibiotic therapy, associated with a systematic supportive periodontal therapy, benefits the long-term maintenance of teeth with previous advanced periodontal defects in subjects presenting AgP, supporting this approach as an alternative in the treatment of AgP.
authors.forename: Sergio Júnior
authors.initials: SJ
authors.lastname: Siqueira
authors.forename: Fernanda Vieira
authors.initials: FV
authors.lastname: Ribeiro
authors.forename: Karina Teixeira
authors.initials: KT
authors.lastname: Villalpando
authors.forename: Fabiano Ribeiro
authors.initials: FR
authors.lastname: Cirano
authors.forename: Suzana Peres
authors.initials: SP
authors.lastname: Pimentel
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000517:prevention & control*; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000601:surgery; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003746:Dental Enamel Proteins / Q000627:therapeutic use; D004338:Drug Combinations; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D013357:Subgingival Curettage / Q000379:methods; D013524:Surgical Flaps / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D003746:Dental Enamel Proteins; D004338:Drug Combinations; C109069:enamel matrix proteins; D008795:Metronidazole; D000658:Amoxicillin