title: Excluding T Cells: Is β-Catenin the Full Story?
abstract: Spranger and colleagues reported recently in Nature an inverse relationship between melanoma intrinsic β-catenin signaling and intratumoral T cell infiltration, providing an explanation for potential mechanisms of T cell exclusion. Further insights are needed into the mechanisms leading to a lack of T cell infiltration of cancers and primary immune resistance.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Siwen
authors.initials: S
authors.lastname: Hu-Lieskovan
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA.
authors.forename: Blanca
authors.initials: B
authors.lastname: Homet Moreno
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Surgery, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Medical and Molecular Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center (JCCC) at UCLA, Los Angeles, CA 90095, USA. Electronic address: aribas@mednet.ucla.edu.
authors.forename: Antoni
authors.initials: A
authors.lastname: Ribas
mesh_terms: D000818:Animals; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000503:physiopathology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology*; D051176:beta Catenin / Q000276:immunology*
chemical_list: D051176:beta Catenin