title: Effects of dexmedetomidine pretreatment on heme oxygenase-1 expression and oxidative stress during one-lung ventilation.
abstract: OBJECTIVE
  This study aimed to explore effects of dexmedetomidine pretreatment on heme oxygenase-1 (HO-1) expression and oxidative stress during one-lung ventilation (OLV) in lung cancer patients.
  
  
  METHODS
  Fifty patients with lung carcinoma (ASA I-II, 40-65 years old, body mass index [BMI]<30 kg/m2) undergoing pulmonary lobectomy were enrolled. They were divided randomly into two equal groups before anaesthesia induction to receive either intravenous injection of 1 μg/kg dexmedetomidine for 20 min (Dexmedetomidine) or not (Control).
  
  
  RESULTS
  The results showed no difference in heart rate (HR), mean arterial pressure (MAP) and bispectral index (BIS) between the two groups, as well as liquid intake and output volume (LIO), duration of OLV and time from surgery beginning to excision of pathological tissues (P>0.05). Levels of tumor necrosis factor (TNF-α) and malondialdehyde (MDA) in Dexmedetomidine group were lower than that of Control at OLV 60 and 90 (P<0.05). Superoxide dismutase (SOD) activity and the expression level of HO-1 were higher in Dexmedetomidine group than in Control (P<0.05).
  
  
  CONCLUSIONS
  Dexmedetomidine pretreatment could upregulated expression of HO-1 in lung tissue and reduce oxidative stress and inflammation during OLV. Thus dexmedetomidine played a role in protecting lung injury by promoting HO-1 expression.
authors.affiliation: Department of Anesthesiology, Qianfo Mountain Hospital of Shandong University Jinan 250014, China ; Department of Anesthesiology, Taian Central Hospital Taian 271000, China.
authors.forename: Shenqiang
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Anesthesiology, Qianfo Mountain Hospital of Shandong University Jinan 250014, China.
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Taian Central Hospital Taian 271000, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Nephrology, Mount Tai Hospital of Shandong Province Taian 271000, China.
authors.forename: Aiping
authors.initials: A
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000601:surgery*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D051547:Heme Oxygenase-1 / Q000096:biosynthesis; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D011013:Pneumonectomy
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
keywords: Dexmedetomidine; heme oxygenase-1; one-lung ventilation; oxidative stress