title: The influence of Sr content in calcium phosphate coatings.
abstract: In this study calcium phosphate coatings with different amounts of strontium (Sr) were prepared using a biomineralization method. The incorporation of Sr changed the composition and morphology of coatings from plate-like to sphere-like morphology. Dissolution testing indicated that the solubility of the coatings increased with increased Sr concentration. Evaluation of extracts (with Sr concentrations ranging from 0 to 2.37 μg/mL) from the HA, 0.06Sr, 0.6Sr, and 1.2Sr coatings during in vitro cell cultures showed that Sr incorporation into coatings significantly enhanced the ALP activity in comparison to cells treated with control and HA eluted media. These findings show that calcium phosphate coatings could promote osteogenic differentiation even in a low amount of strontium.
authors.affiliation: Department of Biomaterials, Institute for Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; BIOMATCELL, VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden.
authors.forename: Carl
authors.initials: C
authors.lastname: Lindahl
authors.affiliation: Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Shiuli
authors.initials: S
authors.lastname: Pujari-Palmer
authors.affiliation: Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hoess
authors.affiliation: Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Marjam
authors.initials: M
authors.lastname: Ott
authors.affiliation: BIOMATCELL, VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden; Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Engqvist
authors.affiliation: BIOMATCELL, VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden; Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala, Sweden. Electronic address: wei.xia@angstrom.uu.se.
authors.forename: Wei
authors.initials: W
authors.lastname: Xia
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D012995:Solubility; D013324:Strontium / Q000737:chemistry* / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C020243:calcium phosphate; D013324:Strontium
keywords: Calcium phosphate coatings; In vitro study; Ion release; Strontium