title: Two-way communication between the metabolic and cell cycle machineries: the molecular basis.
abstract: The relationship between cellular metabolism and the cell cycle machinery is by no means unidirectional. The ability of a cell to enter the cell cycle critically depends on the availability of metabolites. Conversely, the cell cycle machinery commits to regulating metabolic networks in order to support cell survival and proliferation. In this review, we will give an account of how the cell cycle machinery and metabolism are interconnected. Acquiring information on how communication takes place among metabolic signaling networks and the cell cycle controllers is crucial to increase our understanding of the deregulation thereof in disease, including cancer.
authors.affiliation: a Division of Molecular Oncology; The Netherlands Cancer Institute ; Amsterdam ; The Netherlands.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kaplon
authors.forename: Loes
authors.initials: L
authors.lastname: van Dam
authors.forename: Daniel
authors.initials: D
authors.lastname: Peeper
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
keywords: cell cycle; cyclin-dependent kinases; glycolysis; metabolism; nutrients; proliferation