title: Designed filamentous cell penetrating peptides: probing supramolecular structure-dependent membrane activity and transfection efficiency.
abstract: In this work, we will demonstrate a simple yet powerful strategy to assemble single-chain cationic peptides into macromolecular filamentous nanostructures with dramatically improved membrane activity, stability and transfection efficiency.
authors.affiliation: Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA. hdong@clarkson.edu.
authors.forename: Dawei
authors.initials: D
authors.lastname: Xu
authors.forename: Derek
authors.initials: D
authors.lastname: Dustin
authors.forename: Linhai
authors.initials: L
authors.lastname: Jiang
authors.forename: Damien S K
authors.initials: DS
authors.lastname: Samways
authors.forename: He
authors.initials: H
authors.lastname: Dong
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D057846:Cell-Penetrating Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry*; D014162:Transfection
chemical_list: D057846:Cell-Penetrating Peptides; D046911:Macromolecular Substances