title: [Investigations on the acute, carrageenan-induced inflammatory reaction and pharmacology of orally administered sodium salicylate in turkeys].
abstract: The complex mechanisms of acute inflammation have been subject to veterinary investigations since a long time. However, knowledge on the role of specific inflammatory mediators, as well as pharmacokinetics (PK) and -dynamics (PD) of non-steroidal anti-inflammatory drugs (NSAID) in birds is limited. The objective of this work therefore was to establish a modified tissue cage-model to investigate the acute, carrageenan-mediated inflammatory response, as well as plasma and exudate-kinetics and the antiphlogistic effect of orally administered sodium salicylate on the elicited inflammatory reaction in turkeys. Within the class Aves, comparable studies have so far only been published in chicken. Following bilateral subcutaneous implantation of carrageenan-treated synthetic sponges in the lateral thoracic region, sodium salicylate was administered orally at a dose of 50 mg/kg body weight (BW; therapy group) twice daily on three consecutive days, while a control group received drinking water as a placebo (n = 24 per group). Combined PK and PD of sodium salicylate were evaluated on the basis of salicylate- and prostaglandin (PG) E2-plasma- and -exudate-concentrations, exudate volumes, as well as leukocyte exudate counts. Sodium salicylate was readily absorbed from the gastrointestinal tract and accumulated in the inflammatory exudate. At 4, 6, and 10 h after first application, sodium salicylate significantly reduced PG E2-concentrations in the inflammatory exudate when compared to the control group, whereas leukocyte exudate counts increased over time in both study groups, unaffected by sodium salicylate The described modified tissue cage-model can be beneficial for further research on the pathophysiology of avian inflammatory processes and the investigation of the combined pharmacodynamics and -kinetics of drugs in birds of adequate size.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Cramer
authors.forename: Volker
authors.initials: V
authors.lastname: Schmidt
authors.forename: Andreas
authors.initials: A
authors.lastname: Richter
authors.forename: Herbert
authors.initials: H
authors.lastname: Fuhrmann
authors.forename: Getu
authors.initials: G
authors.lastname: Abraham
authors.forename: Maria-Elisabeth
authors.initials: ME
authors.lastname: Krautwald-Junghanns
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002351:Carrageenan; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D007958:Leukocyte Count; D011201:Poultry Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D012980:Sodium Salicylate / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014422:Turkeys
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan; D012980:Sodium Salicylate