title: Astragalin Attenuates Allergic Inflammation in a Murine Asthma Model.
abstract: The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.
authors.affiliation: Department of Pharmacology, Shaanxi University of Chinese Medicine, Xianyang, China, 712046.
authors.forename: Jiping
authors.initials: J
authors.lastname: Liu
authors.forename: Yue
authors.initials: Y
authors.lastname: Cheng
authors.forename: Xiaoshuang
authors.initials: X
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Shuxian
authors.initials: S
authors.lastname: Chen
authors.forename: Zongmiao
authors.initials: Z
authors.lastname: Hu
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhou
authors.forename: Enhu
authors.initials: E
authors.lastname: Zhang
authors.forename: Shiping
authors.initials: S
authors.lastname: Ma
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001249:Asthma / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D044949:Kaempferols / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D044949:Kaempferols; D010047:Ovalbumin; C001579:astragalin