title: [Nanocerium restores the erythrocytes stability to acid hemolysis by inhibition of oxygen and nitrogen reactive species in old rats].
abstract: In experiments in vivo the effect of nanocerium (cerium oxide nanoparticles) on the stability of red blood cells to acid hemolysis, levels of both ROS and RNS generation and H2S pools in plasma and erythrocytes of old rats were investigated. In red blood cells of old rats the proton penetration into the matrix of erythrocytes showed a significant raising and the fate of labile "aging" erythrocytes in old animals compared with adult were up- regulated. These phenomena paralleled with significant up-regulation of ROS and RNS generation. Introduction for 14 days per os to old rats 0.1 mg/kg of nanocerium fully restored resistance of erythrocytes to acid hemolysis by ROS and RNS in both plasma and erythrocytes reduction. Nanocerium decreased the erythrocytes and, conversely, significantly increased the plasma's pools of H2S.
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsuruba
authors.forename: B S
authors.initials: BS
authors.lastname: Kopjak
authors.forename: V F
authors.initials: VF
authors.lastname: Sagach
authors.forename: N Ja
authors.initials: NJ
authors.lastname: Spivak
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000097:blood* / Q000473:pathology; D000818:Animals; D021461:Animals, Outbred Strains; D002478:Cells, Cultured; D002563:Cerium / Q000008:administration & dosage* / Q000378:metabolism; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000097:blood; D053758:Nanoparticles / Q000008:administration & dosage* / Q000378:metabolism; D009996:Osmotic Fragility / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D026361:Reactive Nitrogen Species / Q000037:antagonists & inhibitors* / Q000097:blood; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000097:blood
chemical_list: D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide; D006862:Hydrogen Sulfide