title: Application of concentrated growth factors in reconstruction of bone defects after removal of large jaw cysts--the two cases report.
abstract: BACKGROUND
  Coagulation and blood clot formation in bone defects is sometimes followed by retraction of a blood clot and serum extrusion, thus producing peripheral serum-filled spaces between bony wall and coagulum. This can result in a higher incidence of postoperative complications. Stabilization of blood coagulum, which enables successful primary healing, may be accomplished by autotransplantation, allotransplantation, xenotransplantation, or application of autologous platelet concentrate and concentrated growth factors (CGF). Case report. Two patients with large cystic lesions in the upper and lower jaw were presented. In both patients postoperative bony defects were filled with autologous fibrin rich blocks containing CGF. Postoperative course passed uneventfully.
  
  
  CONCLUSIONS
  Application of fibrin rich blocks containing CGF is one of the possible methods for reconstruction of bone defects. CGF can be applied alone or mixed with a bone graft. The method is relatively simple, without risk of transmissible and allergic diseases and economically feasible.
authors.forename: Siniga
authors.initials: S
authors.lastname: Mirković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Djurdjević-Mirković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Pugkar
mesh_terms: D000328:Adult; D001861:Bone Regeneration / Q000187:drug effects; D054893:Cone-Beam Computed Tomography / Q000379:methods; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use*; D007570:Jaw Cysts / Q000175:diagnosis / Q000601:surgery; D008297:Male; D063168:Mandibular Osteotomy / Q000009:adverse effects* / Q000379:methods; D063166:Maxillary Osteotomy / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000295:instrumentation / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D036341:Intercellular Signaling Peptides and Proteins