title: Asymmetric Reduction of Electron-Rich Ketones with Tethered Ru(II)/TsDPEN Catalysts Using Formic Acid/Triethylamine or Aqueous Sodium Formate.
abstract: The asymmetric transfer hydrogenation (ATH) of ketones under aqueous conditions using tethered Ru(II)/η(6)-arene/diamine catalysts is described, as is the ATH of electron-rich substrates containing amine and methoxy groups on the aromatic rings. Although such substrates are traditionally challenging ones for ATH, the tethered catalysts work very efficiently. In the case of amino-substituted ketones, aqueous conditions give excellent results; however, for methoxy-substituted substrates, the more established formic acid/triethylamine system gives superior results.
authors.affiliation: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Rina
authors.initials: R
authors.lastname: Soni
authors.affiliation: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Hall
authors.affiliation: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Mitchell
authors.affiliation: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Owen
authors.affiliation: Department of Chemistry, The University of Warwick, Coventry, CV4 7AL, United Kingdom.
authors.forename: Martin
authors.initials: M
authors.lastname: Wills