title: [Sclerostin: a new biomarker of interest in nephrology].
abstract: Sclerostin is an osteocyte-specific glycoprotein secreted by the osteocyte and involved in the regulation of bone mass. High sclerostin levels are associated with osteoporosis, whereas low sclerostin levels are correlated with higher bone mineral density. It seems interesting to investigate a potential association between sclerostin levels and vascular calcifications since sclerostin is considered as a potent inhibitor of bone formation. In chronic kidney disease, serum sclerostin levels rise as renal function declines. Preliminary studies show a positive association between serum sclerostin and vascular calcification, but the link between sclerostin and survival of patients remains unclear in the absence of large-scale studies.
authors.affiliation: Université Lyon 1, Faculté de médecine, Inserm U1033 Physiopathologie, diagnostic et traitements des maladies osseuses et service de néphrologie-dialyse-nutrition, Centre hospitalier Lyon-Sud, France.
authors.forename: Solenne
authors.initials: S
authors.lastname: Pelletier
authors.affiliation: Nephrocare Tassin-Charcot, Sainte-Foy-Lès-Lyon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jean
authors.affiliation: Carmen, CENS, Université de Lyon et Service de néphrologie-dialyse-nutrition, Centre hospitalier Lyon-Sud, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Fouque
authors.affiliation: Université Lyon 1, Faculté de médecine, Inserm U1033 Physiopathologie, diagnostic et traitements des maladies osseuses et service de néphrologie-dialyse-nutrition, Centre hospitalier Lyon-Sud, France, Nephrocare Tassin-Charcot, Sainte-Foy-Lès-Lyon, France, Carmen, CENS, Université de Lyon et Service de néphrologie-dialyse-nutrition, Centre hospitalier Lyon-Sud, France.
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D005819:Genetic Markers / Q000502:physiology*; D006801:Humans; D009398:Nephrology; D051436:Renal Insufficiency, Chronic / Q000209:etiology*; D061205:Vascular Calcification / Q000209:etiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human
keywords: bone; sclerostin; vascular calcification