title: Polymorphisms in TP53 are associated with risk and survival of osteosarcoma in a Chinese population.
abstract: Osteosarcoma (OS) is the most frequent histological form of primary bone cancer in adolescence. TP53 is a tumor suppressor gene which is essential for regulating cell division and preventing tumor formation. The purpose of this study is to examine whether genetic mutations in the TP53 gene are associated with OS risk and survival in a Chinese population. Five polymorphisms in the TP53 gene were selected in a case-control study, including 210 OS patients and 420 cancer-free controls. We found that subjects carrying rs12951053 CC genotype and rs1042522 GG genotype were significantly associated with risk of OS [odds ratio (OR)=1.68, 95% confidence intervals (CI): 1.05-2.68; OR=1.89, 95% CI: 1.16-3.07] compared with subjects carrying the common genotypes. Results of haplotype analysis also showed that A-G-G-A-C haplotype (rs12951053, rs1042522, rs8064946, rs9895829 and rs12602273) conferred significant decreased risk of OS (OR=0.37, 95% CI: 0.19-0.72) compared with A-C-G-A-C haplotype. Besides, rs1042522 was an independent prognostic factor for OS with hazard radio (HR)=1.94 (95% CI: 1.03-3.65) in GG genotype than in CC genotype. Our data suggest that genetic mutations in the TP53 gene are associated with risk and survival of OS in Chinese population.
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Jiang-Ying
authors.initials: JY
authors.lastname: Ru
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cong
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Kang
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Tin
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, China.
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D001859:Bone Neoplasms / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics* / Q000401:mortality; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D055815:Young Adult
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
keywords: Osteosarcoma; TP53; haplotype; polymorphism; survival; susceptibility