title: The TF-miRNA Coregulation Network in Oral Lichen Planus.
abstract: Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa, some of which may finally develop into oral squamous cell carcinoma. Therefore, pinpointing the molecular mechanisms underlying the pathogenesis of OLP is important to develop efficient treatments for OLP. Recently, the accumulation of the large amount of omics data, especially transcriptome data, provides opportunities to investigate OLPs from a systematic perspective. In this paper, assuming that the OLP associated genes have functional relationships, we present a new approach to identify OLP related gene modules from gene regulatory networks. In particular, we find that the gene modules regulated by both transcription factors (TFs) and microRNAs (miRNAs) play important roles in the pathogenesis of OLP and many genes in the modules have been reported to be related to OLP in the literature.
authors.affiliation: Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Shierqiao Road 39, Chengdu, Sichuan 610072, China.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Zuo
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Di-Ping
authors.initials: DP
authors.lastname: Gong
authors.affiliation: Preclinical Medicine College, Chengdu University of Traditional Chinese Medicine, Shierqiao Road 37, Chengdu, Sichuan 610075, China.
authors.forename: Bi-Ze
authors.initials: BZ
authors.lastname: Li
authors.affiliation: Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Shierqiao Road 37, Chengdu, Sichuan 610075, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Shierqiao Road 37, Chengdu, Sichuan 610075, China.
authors.forename: Ling-Yue
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Fang-Yang
authors.initials: FY
authors.lastname: Shao
authors.affiliation: College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Shierqiao Road 37, Chengdu, Sichuan 610075, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D017676:Lichen Planus, Oral / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009061:Mouth Mucosa / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics*; D059467:Transcriptome / Q000235:genetics
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors