title: Efficacy of adjunctive mitomycin C in transcanalicular diode laser dacryocystorhinostomy in different age groups.
abstract: OBJECTIVE
  To evaluate the efficacy of adjunctive mitomycin C (MMC) in transcanalicular multidiode laser dacryocystorhinostomy (TCL-DCR) in different age groups.
  
  
  METHODS
  Ninety-six eyes of 96 patients who underwent TCL-DCR for the treatment of nasolacrimal duct obstruction were included in this retrospective, comparative study. Patients were divided into 4 groups based on age and intraoperative use of MMC: group 1, TCL-DCR without MMC in the 20- to 44-year age group; group 2, TCL-DCR with MMC in the 20- to 44-year age group; group 3, TCL-DCR without MMC in the 45- to 76-year age group; group 4, TCL-DCR with MMC in the 45- to 76-year age group. The postoperative evaluation consisted of calculating and comparing the success rates between groups.
  
  
  RESULTS
  Success rates at the final visit were 50% for group 1, 66.66% for group 2, 79.16% for group 3, and 84.61% for group 4. The differences between group 1 and group 4, and group 1 and group 3, were significant (p = 0.01 and p = 0.038, respectively). Logistic regression showed that age group had significant effect on success rate (p = 0.013). However, use of MMC had no significant effect on success rate (p = 0.23).
  
  
  CONCLUSIONS
  The success rates of the TCL-DCR with MMC application were found to be higher than those of TCL-DCR without MMC in different age groups. However, the differences did not reach statistical significance. In addition, our study demonstrated that age may be a significant factor influencing the surgical outcome of TCL-DCR.
authors.affiliation: Ophthalmology Department, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul - Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Kar
authors.affiliation: Ophthalmology Department, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul - Turkey.
authors.forename: Yildiray
authors.initials: Y
authors.lastname: Yildirim
authors.affiliation: Ophthalmology Department, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul - Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Topal
authors.affiliation: Ophthalmology Department, Kasımpaşa Military Hospital, Istanbul - Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Çolakoğlu
authors.affiliation: Ophthalmology Department, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul - Turkey.
authors.forename: Melih Hamdi
authors.initials: MH
authors.lastname: Ünal
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003608:Dacryocystorhinostomy / Q000379:methods*; D005260:Female; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000188:drug therapy / Q000628:therapy*; D054023:Lasers, Semiconductor / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D009301:Nasolacrimal Duct / Q000187:drug effects* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin