title: Animal Models--Decoding the Molecular Biology of Oral Cancer.
abstract: Animal models have long been used to understand the initiation and progression of carcinogenesis, including that of oral mucosa.(1) One of the earliest models used was the chemical-induced oral cancer model, among which the Syrian Hamster check pouch was preferred for its ideal anatomical location and physiological features.(2) Salley et al(3) demonstrated that the cheek pouch mucosa underwent gradual changes from hyperplasia, carcinoma in situ to squamous cell carcinoma when exposed to polycyclic hydrocarbon 9, 10 dimethyl-1,2, benzanthracene (DMBA). Morris(4) standardized the dosage of carcinogen to 0.5% solution of DMBA in acetone and established that 5-week old animals were ideal to induce tumor with minimum time lag and maximum yield. Lin et al(5) demonstrated the synergistic effect of arecaidine with DMBA.
authors.affiliation: Associate Professor, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Shankargouda
authors.initials: S
authors.lastname: Patil
authors.affiliation: Professor and Head, Department of Oral Pathology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
authors.forename: Roopa
authors.initials: R
authors.lastname: Rao
authors.forename: Thirumal
authors.initials: T
authors.lastname: Raj
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D045744:Cell Line, Tumor; D003043:Cocarcinogenesis / Q000235:genetics; D006224:Cricetinae; D004195:Disease Models, Animal; D018450:Disease Progression; D051379:Mice; D008967:Molecular Biology; D009062:Mouth Neoplasms / Q000235:genetics*; D009368:Neoplasm Transplantation; D009857:Oncogenes / Q000235:genetics; D051381:Rats
chemical_list: D002273:Carcinogens