title: Myeloperoxidase genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children.
abstract: OBJECTIVE
  The aim of this study was to investigate the myeloperoxidase (MPO) -463G>A polymorphism in Kawasaki disease (KD) patients, and the relationship between gene polymorphism and MPO levels.
  
  
  METHODS
  A total of 334 KD children and 492 sex-matched controls were assayed for polymorphism analysis. TaqMan assays were used for genotyping. MPO was measured in 37 KD patients and 42 febrile controls.
  
  
  RESULTS
  A significant linear trend of KD risk was found to be related to the G/G genotype (plinear trend= 0.032). The combined genotypes (G/A and A/A) of MPO -463G>A were associated with a significantly decreased KD risk compared to the G/G genotype [adjusted odds ratios (AOR) = 0.71, 95% confidence interval (CI): 0.52-0.99, p = 0.040]. In addition, KD patients with A allele were associated with a significantly decreased KD risk as compared to those with G allele (AOR = 0.73, 95% CI: 0.54-0.98, p = 0.033). MPO levels were significantly elevated in KD patients in preintravenous immunoglobulin (pre-IVIG) stage compared to febrile controls (p = 0.002). KD patients in pre-IVIG stage had significantly higher MPO levels than febrile controls in terms of G/G genotype (p = 0.003) and G allele (p < 0.001). KD patients with A allele had significantly lower MPO levels than those with G allele in post-IVIG acute stage (p = 0.042). However, there was no significant difference of individual MPO change for KD patients from pre- to post-IVIG stage in terms of genotypes (p = 0.837) or alleles (p = 0.631).
  
  
  CONCLUSIONS
  Our results suggest that G allele of MPO -463G>A polymorphism is a potential genetic marker for KD risk in Taiwanese children.
authors.affiliation: Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan; Shu-Zen College of Medicine and Management, Kaohsiung, Taiwan. Electronic address: kenpenweng@yahoo.com.tw.
authors.forename: Ken-Pen
authors.initials: KP
authors.lastname: Weng
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
authors.forename: Kai-Sheng
authors.initials: KS
authors.lastname: Hsieh
authors.affiliation: Department of Nursing, Fooyin University, Kaohsiung, Taiwan.
authors.forename: Shih-Hui
authors.initials: SH
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
authors.forename: Huang-Wei
authors.initials: HW
authors.lastname: Wu
authors.affiliation: Department of Pediatrics, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
authors.forename: Jen-Hung
authors.initials: JH
authors.lastname: Chien
authors.affiliation: Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chu-Chuan
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, and National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chia-Wan
authors.initials: CW
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Antai Tian-Sheng Memorial Hospital, Pingtung, Taiwan.
authors.forename: Shan-Fu
authors.initials: SF
authors.lastname: Ou
authors.affiliation: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Sin-Jhih
authors.initials: SJ
authors.lastname: Huang
authors.affiliation: Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address: lpger@vghks.gov.tw.
authors.forename: Luo-Ping
authors.initials: LP
authors.lastname: Ger
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D009195:Peroxidase / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013624:Taiwan
chemical_list: D009195:Peroxidase
keywords: Kawasaki disease; myeloperoxidase; polymorphism