title: With Cytometric Bead Assay, the Interleukin-10/HBV DNA Ratio Is an Early Predictor for Response to Interferon-α Treatment in Chronic Hepatitis B.
abstract: Both host immunity and hepatitis B virus (HBV) contribute to the therapeutic response to interferon (IFN)-α treatment in chronic hepatitis B (CHB) based on the immune modulation function to eliminate virus, while neither viral load nor cytokine alone could reflect the complex interaction between host immune response and virus. This study aimed at exploring a parameter of combined immunological and virological indexes to predict the response profile to IFN-α treatment in patients with CHB. Biochemical (alanine transaminase), virological (HBV DNA load, HBsAg, HBeAg), and immunological [IFN-γ, tumor necrosis factor (TNF), interleukin (IL)-2, IL-4, IL-6, and IL-10] indexes were dynamically monitored (at baseline, 2, 4, 8, 12, 24, 36, 48, and 72 weeks) in 41 patients who received a 48-week IFN-α treatment. First, we found that responders displayed an elevation in both Th1 and Th2 type cytokines from baseline to 4 weeks. What is more, the HBV DNA load at the baseline and IL-10 at 4 weeks showed significant differences between responders and nonresponders and were highly associated with the response to IFN-α treatment. More importantly, IL-10/HBV DNA was identified as a positive predictor for response to IFN-α treatment (odds ratio=5.785) by logistic regression analysis. We show here that the IL-10/HBV DNA ratio, a parameter of combined immunological and virological factors, can be useful in predicting the response to IFN-α treatment in CHB.
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Taotao
authors.initials: T
authors.lastname: Yan
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yingli
authors.initials: Y
authors.lastname: He
authors.affiliation: 2 Department of Infectious Diseases, Xi'an Children's Hospital , Xi'an, China .
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Tianyan
authors.initials: T
authors.lastname: Chen
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Ruitian
authors.initials: R
authors.lastname: Yi
authors.affiliation: 1 Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yingren
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers; D004279:DNA, Viral; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D016898:Interferon-alpha; D016753:Interleukin-10