title: Hemolysis from ABO Incompatibility.
abstract: ABO incompatibility of red blood cells leads to brisk complement-mediated lysis, particularly in the setting of red cell transfusion. The ABO blood group is the most clinically significant blood group because of preformed immunoglobulin M (IgM) and IgG antibodies to ABO blood group antigens (isohemagglutinins) in everyone except group AB individuals. In addition to transfusion, ABO incompatibility can cause hemolysis in hematopoietic and solid organ transplantation, hemolytic disease of the newborn, and intravenous immunoglobulin infusion. It is important to prevent ABO incompatibility when possible and to anticipate complications when ABO incompatibility is unavoidable.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Daimon P
authors.initials: DP
authors.lastname: Simmons
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: wjsavage@partners.org.
authors.forename: William J
authors.initials: WJ
authors.lastname: Savage
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control*; D001788:Blood Grouping and Crossmatching / Q000379:methods; D017690:Cell Transplantation / Q000009:adverse effects; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D016378:Tissue Transplantation / Q000009:adverse effects; D065227:Transfusion Reaction
chemical_list: D000017:ABO Blood-Group System
keywords: ABH antigens; ABO blood group; Complement; Hemolysis; Isohemagglutinins; Major incompatibility; Minor incompatibility