title: Report: Osteocyte enhancement function of bisphosphonates in prosthetic replacement.
abstract: Aseptic loosening after prosthetic replacement is the primary cause of shortened service life and lowered stability of prosthesis, and increased revision rate after joint replacement. Factors of causing the loosening of joint prosthesis include mechanical factors and biological factors. The mechanical effect of bisphosphonates (BP) is quite obvious, which can enhance osteocyte function, accelerate the generation of new bone and lower bone resorption activity of osteoclast and macrophage. In animal experiment and adjuvant therapy of patients after joint replacement, BP also shows up the functions of reducing osteolysis induced by wear debris, preventing stress shielding and interface fretting and enhancing bone density. This paper elaborated the mechanism of BP adjusting bone metabolism, and analyzed the action principle and the vital function of it in prosthetic replacement. It has proved that BP can effectively reduce the early peri-prosthesis bone absorption after total hip replacement and improve bone mass peri-prosthesis. It is currently the significant choice of preventing bone lose of peri-prosthesis after operation.
authors.affiliation: Joint Department of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Joint Department of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Shangzeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Rheumatism Bone Disease Department of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Qingliang
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Joint Department of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Spinal Department of Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China.
authors.forename: A-fou
authors.initials: AF
authors.lastname: Ran
mesh_terms: D000818:Animals; D019643:Arthroplasty, Replacement / Q000009:adverse effects / Q000295:instrumentation*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016723:Bone Remodeling / Q000187:drug effects*; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007595:Joint Prosthesis; D010011:Osteocytes / Q000187:drug effects* / Q000378:metabolism; D011475:Prosthesis Failure; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates