title: [Oncotoxic proteins in cancer therapy: mechanisms of action].
abstract: Cancer therapeutics based on protein biomolecules that exhibit selective toxic of inhibiting effects towards tumor cells without affecting normal tissue, are gaining extensive attention in cancer research. This heterogenous group of proteins consists of several subgroups, among them, are engineered cancer antigen-specific antibodies that suppress tumor growth by blocking proliferation-inducing receptors, or by direct action of a covalently attached toxin. Another subgroup of anticancer proteins that also represents promising potential therapeutic agents is oncotoxic proteins that can selectively trigger proapoptotic signaling in cancer cells. The oncotoxic proteins target such commonly disturbed processes in tumor calls as enhanced cell proliferation, altered cell-cycle control, deficient apoptotic response, inhibited mitochondrial respiration and activated glycolysis. The introduction of oncotoxic proteins to the clinic might substantially widen and upgrade modern arsenal of anticancer therapeutics.
authors.forename: Y N
authors.initials: YN
authors.lastname: Lezhnin
authors.forename: J E
authors.initials: JE
authors.lastname: Kravchenko
authors.forename: E I
authors.initials: EI
authors.lastname: Frolova
authors.forename: P M
authors.initials: PM
authors.lastname: Chumakov
authors.forename: S P
authors.initials: SP
authors.lastname: Chumakov
mesh_terms: D000818:Animals; D000912:Antibodies, Neoplasm / Q000235:genetics / Q000627:therapeutic use*; D057134:Antibodies, Neutralizing / Q000235:genetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015202:Protein Engineering; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000912:Antibodies, Neoplasm; D057134:Antibodies, Neutralizing; D000970:Antineoplastic Agents