title: Cross-talk between bile acids and intestinal microbiota in host metabolism and health.
abstract: Bile acid (BA) is de novo synthesized exclusively in the liver and has direct or indirect antimicrobial effects. On the other hand, the composition and size of the BA pool can be altered by intestinal microbiota via the biotransformation of primary BAs to secondary BAs, and subsequently regulate the nuclear farnesoid X receptor (FXR; NR1H4). The BA-activated FXR plays important roles in BA synthesis and metabolism, glucose and lipid metabolism, and even hepatic autophagy. BAs can also play a role in the interplays among intestinal microbes. In this review, we mainly discuss the interactions between BAs and intestinal microbiota and their roles in regulating host metabolism, and probably the autophagic signaling pathway.
authors.affiliation: College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China.
authors.forename: Yang-fan
authors.initials: YF
authors.lastname: Nie
authors.forename: Jun
authors.initials: J
authors.lastname: Hu
authors.forename: Xiang-hua
authors.initials: XH
authors.lastname: Yan
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D004764:Enterohepatic Circulation / Q000502:physiology*; D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D020239:Receptor Cross-Talk / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear; D000099150:Receptor, Farnesoid X-Activated
keywords: Autophagy; Bile acid (BA); Farnesoid X receptor (FXR); Host metabolism; Intestinal microbiota