title: Radical Prostatectomy for Locally Advanced Prostate Cancer: Current Status.
abstract: In the past, prostate cancer (PC) could only be detected clinically, and delayed diagnosis of locally advanced or metastatic disease at presentation was common. Prostate-specific antigen testing and magnetic resonance imaging led to PC detection in a much earlier stage. However, controversy about the best treatment for locally advanced PC remains. Recent refinements in surgery and radiation therapy have improved outcomes, but no comparative study has yet conclusively determined superiority of one option over the other. In this review, we present the most recent evidence about the role of radical prostatectomy for locally advanced PC treatment from a surgeon's perspective.
authors.affiliation: Surgical Uro-Oncology Department, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil. Electronic address: elineyferreirafaria@yahoo.com.br.
authors.forename: Eliney F
authors.initials: EF
authors.lastname: Faria
authors.affiliation: Division of Surgery, Department of Urology, University of Texas, MD Anderson Cancer Center, Houston, TX.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Chapin
authors.affiliation: Surgical Uro-Oncology Department, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil.
authors.forename: Roberto L
authors.initials: RL
authors.lastname: Muller
authors.affiliation: Surgical Uro-Oncology Department, Barretos Cancer Hospital, Barretos, Sao Paulo, Brazil.
authors.forename: Roberto D
authors.initials: RD
authors.lastname: Machado
authors.affiliation: Urology Department, Sao Paulo University (Ribeirao Preto), Ribeirao Preto, Sao Paulo, Brazil.
authors.forename: Rodolfo B
authors.initials: RB
authors.lastname: Reis
authors.affiliation: Division of Surgery, Department of Urology, University of Texas, MD Anderson Cancer Center, Houston, TX.
authors.forename: Surena F
authors.initials: SF
authors.lastname: Matin
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*