title: A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer.
abstract: Several published studies identified associations of a number of polymorphisms with a variety of survival outcomes in colorectal cancer. In this study, we aimed to explore 102 previously reported common genetic polymorphisms and their associations with overall survival (OS) and disease-free survival (DFS) in a colorectal cancer patient cohort from Newfoundland (n = 505). Genotypes were obtained using a genomewide SNP genotyping platform. For each polymorphism, the best possible genetic model was estimated for both overall survival and disease-free survival using a previously published approach. These SNPs were then analyzed under their genetic models by Cox regression method. Correction for multiple comparisons was performed by the False Discovery Rate (FDR) method. Univariate analysis results showed that RRM1-rs12806698, IFNGR1-rs1327474, DDX20-rs197412, and PTGS2-rs5275 polymorphisms were nominally associated with OS or DFS (p < 0.01). In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes. We conclude that polymorphisms investigated in this study are not associated with OS or DFS in our colorectal cancer patient cohort.
authors.affiliation: Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6 ; Discipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Sevtap
authors.identifier: 0000-0002-7324-938X
authors.initials: S
authors.lastname: Savas
authors.affiliation: Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9.
authors.forename: Jingxiong
authors.initials: J
authors.lastname: Xu
authors.affiliation: Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Salem
authors.initials: S
authors.lastname: Werdyani
authors.affiliation: Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Shestopaloff
authors.affiliation: Clinical Epidemiology Unit, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Dicks
authors.affiliation: Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Jane
authors.initials: J
authors.lastname: Green
authors.affiliation: Clinical Epidemiology Unit, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Patrick
authors.initials: P
authors.lastname: Parfrey
authors.affiliation: Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
authors.forename: Roger
authors.initials: R
authors.lastname: Green
authors.affiliation: Department of Biostatistics, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9 ; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7.
authors.forename: Wei
authors.identifier: 0000-0002-0257-8856
authors.initials: W
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics*; D055541:DEAD Box Protein 20 / Q000235:genetics*; D018572:Disease-Free Survival; D000091342:Endoplasmic Reticulum Chaperone BiP; D005260:Female; D056726:Genetic Association Studies; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D000091342:Endoplasmic Reticulum Chaperone BiP; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; C120168:DDX20 protein, human; D055541:DEAD Box Protein 20