title: The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging.
abstract: Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets.
authors.affiliation: Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Health School, University of Vale do Rio dos Sinos (UNISINOS), Sao Leopoldo, Brazil. Electronic address: gceruttim@unisinos.br.
authors.forename: Guilherme Cerutti
authors.initials: GC
authors.lastname: Muller
authors.affiliation: Institute of Geriatrics and Gerontology (IGG), PUCRS, Porto Alegre, Brazil.
authors.forename: Maria Gabriela Valle
authors.initials: MG
authors.lastname: Gottlieb
authors.affiliation: Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Luz Correa
authors.affiliation: Institute of Geriatrics and Gerontology (IGG), PUCRS, Porto Alegre, Brazil.
authors.forename: Irênio
authors.initials: I
authors.lastname: Gomes Filho
authors.affiliation: Health Sciences Center, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
authors.affiliation: Laboratory of Immunosenescence, Institute of Biomedical Research, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
authors.forename: Moisés Evandro
authors.initials: ME
authors.lastname: Bauer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000821:virology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000821:virology; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology; D012737:Sex Factors; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology / Q000821:virology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000914:Antibodies, Viral; D017127:Glycation End Products, Advanced; C508600:IL6 protein, human; D015850:Interleukin-6; D017392:Thiobarbituric Acid Reactive Substances; D002097:C-Reactive Protein
keywords: Antioxidant power; Cytomegalovirus; Immune risk profile; Immunosenescence; Inflammation; Oxidative stress