title: Matching Diabetes and Alcoholism: Oxidative Stress, Inflammation, and Neurogenesis Are Commonly Involved.
abstract: Diabetes and alcohol misuse are two of the major challenges in health systems worldwide. These two diseases finally affect several organs and systems including the central nervous system. Hippocampus is one of the most relevant structures due to neurogenesis and memory-related processing among other functions. The present review focuses on the common profile of diabetes and ethanol exposure in terms of oxidative stress and proinflammatory and prosurvival recruiting transcription factors affecting hippocampal neurogenesis. Some aspects around antioxidant strategies are also included. As a global conclusion, the present review points out some common hits on both diseases giving support to the relations between alcohol intake and diabetes.
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Jorge M
authors.initials: JM
authors.lastname: Barcia
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Miguel
authors.identifier: 0000-0003-3421-3699
authors.initials: M
authors.lastname: Flores-Bellver
authors.affiliation: Unidad Predepartamental de Medicina, Universitat Jaume I, 12071 Castellón de la Plana, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Muriach
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Sancho-Pelluz
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lopez-Malo
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Alba C
authors.initials: AC
authors.lastname: Urdaneta
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Natalia
authors.initials: N
authors.lastname: Martinez-Gil
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Atienzar-Aroca
authors.affiliation: Facultad de Medicina y Odontología, Universidad Católica de Valencia "San Vicente Mártir", C/Quevedo 2, 46001 Valencia, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Romero
mesh_terms: D000437:Alcoholism / Q000378:metabolism* / Q000503:physiopathology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D055495:Neurogenesis / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*