title: Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia.
abstract: In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression profiles. In particular, we find some network modules as well as their miRNA regulators that play important roles in the development of OLK to oral cancer. Among these network modules, 91.67% of genes and 37.5% of miRNAs have been previously reported to be related to oral cancer in literature. The promising results demonstrate the effectiveness and efficiency of our proposed approach.
authors.affiliation: Department of Mathematics, Shanghai University, Shanghai 200444, China.
authors.forename: Guanghui
authors.identifier: 0000-0003-1495-4238
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: He
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Shaofang
authors.identifier: 0000-0003-2487-8195
authors.initials: S
authors.lastname: Yang
authors.affiliation: Shanghai Tenth People's Hospital, Middle Yanchang Road 30, Shanghai 200072, China.
authors.forename: Beimin
authors.identifier: 0000-0002-5834-1735
authors.initials: B
authors.lastname: Chen
authors.affiliation: Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Middle Yanchang Road 399, Shanghai 200072, China.
authors.forename: Min
authors.identifier: 0000-0002-6831-3033
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Mathematics, Shanghai University, Shanghai 200444, China.
authors.forename: Xin-Jian
authors.initials: XJ
authors.lastname: Xu
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D007972:Leukoplakia, Oral / Q000150:complications / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009062:Mouth Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D060066:Protein Interaction Maps / Q000235:genetics
chemical_list: D035683:MicroRNAs; D009363:Neoplasm Proteins