title: Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue.
abstract: The α-α helix motif presents key recognition domains in protein-protein and protein-oligonucleotide binding, and is one of the most common super-secondary structures. Herein we describe the design, synthesis and structural characterization of an α-α hairpin analogue based on a tetra-coordinated Pd(II)bis-(iminoisoquinoline) complex as a template for the display of two α-helix mimics. This approach is exemplified by the attachment of two biphenyl peptidomimetics to reproduce the side-chains of theiandi+4residues of two helices.
authors.affiliation: Yale University, Department of Chemistry, P.O. Box 208107, New Haven, CT 06511.
authors.forename: Laura
authors.initials: L
authors.lastname: Nevola
authors.affiliation: Yale University, Department of Chemistry, P.O. Box 208107, New Haven, CT 06511.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Rodriguez
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, England.
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, England ; Yale University, Department of Chemistry, P.O. Box 208107, New Haven, CT 06511.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
keywords: alpha helix, side chain, GCN4; protein-protein interaction; structural mimicry