title: Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
abstract: A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals. The present study aimed to examine the antidepressant-like effect and the possible mechanisms of resveratrol, a naturally occurring polyphenol of phytoalexin family, on depressive-like behavior induced by repeated corticosterone injections in mice. Mice were injected subcutaneously (s.c.) with 40mg/kg corticosterone (CORT) chronically for 21days. Resveratrol and fluoxetine were administered 30min prior to the CORT injection. After 21-days treatment with respective drugs, behavioral and biochemical parameters were estimated. Since brain derived neurotrophic factor (BDNF) has been implicated in antidepressant activity of many drugs, we also evaluated the effect of resveratrol on BDNF in the hippocampus. Three weeks of CORT injections in mice resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test and tail suspension test. Further, there was a significant increase in serum corticosterone level and a significant decrease in hippocampus BDNF level in CORT-treated mice. Treatment of mice with resveratrol significantly ameliorated all the behavioral and biochemical changes induced by corticosterone. These results suggest that resveratrol produces an antidepressant-like effect in CORT-induced depression in mice, which is possibly mediated by rectifying the stress-based hypothalamic-pituitary-adrenal (HPA) axis dysfunction paradigm and upregulation of hippocampal BDNF levels.
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Syed Hamid
authors.initials: SH
authors.lastname: Ali
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Rajaram Mohanrao
authors.initials: RM
authors.lastname: Madhana
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Athira
authors.initials: A
authors.lastname: K V
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India. Electronic address: ishreddy4@gmail.com.
authors.forename: Eshvendar Reddy
authors.initials: ER
authors.lastname: Kasala
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Lakshmi Narendra
authors.initials: LN
authors.lastname: Bodduluru
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Sathish
authors.initials: S
authors.lastname: Pitta
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Jalandhar Reddy
authors.initials: JR
authors.lastname: Mahareddy
authors.affiliation: Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Bhangagarh, Guwahati 781032, Assam, India; Department of Pharmacology, Gauhati Medical College, Bhangagarh, Guwahati 781032, Assam, India.
authors.forename: Mangala
authors.initials: M
authors.lastname: Lahkar
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D003345:Corticosterone / Q000009:adverse effects* / Q000097:blood; D003863:Depression / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D013267:Stilbenes; D000077185:Resveratrol; D003345:Corticosterone
keywords: BDNF; Corticosterone; Depressive-like behavior; HPA axis; Hippocampus; Resveratrol