title: Accelerated RBC senescence as a novel pathologic mechanism of blood stasis syndrome in traditional East Asian medicine.
abstract: Blood stasis syndrome (BSS) is an important pathologic condition in traditional East Asian medicine, characterized by multiple signs and symptoms, including sublingual varicosis, angiotelectasis, slow and choppy pulse, local fixed pain, nyctalgia, menstrual cramps, dark-purple tongue and infra-orbital darkness. However, recent studies have been restricted to the circulatory disorder and could not suggest the pathologic core to explain all of the characteristics of BSS. Here, we review the current research on the senescence of red blood cells (RBCs), focusing on the correlation between the pathologic properties of senescent RBCs and BSS-specific manifestations. The accumulation of senescent RBCs and their products induce pathological conditions that affect blood flow resistance and cause thrombosis, vasoconstriction and methemoglobinemia. These pathological alterations are identical to the characteristics of BSS, therefore supporting the hypothesis that accelerated RBC aging could be considered as a novel pathologic mechanism of BSS.
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine Daejeon, South Korea.
authors.forename: Sooseong
authors.initials: S
authors.lastname: You
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine Daejeon, South Korea.
authors.forename: Bongki
authors.initials: B
authors.lastname: Park
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine Daejeon, South Korea.
authors.forename: Myeong Soo
authors.initials: MS
authors.lastname: Lee
keywords: Blood stasis syndrome; red blood cell; senescence