title: Prenatal risk stratification of severe small-for-gestational-age infants: a Japanese multicenter study.
abstract: OBJECTIVE
  To establish a prenatal prognostic classification of severe small-for-gestational-age (SGA) infants based on gestational age and fetal findings.
  
  
  METHODS
  A retrospective cohort study of 366 singleton infants (birth weight <3rd percentile) delivered between 22 and 34 weeks' gestation at nine tertiary perinatal centers. A decision tree model was developed for the prediction of death or severe morbidity.
  
  
  RESULTS
  There were 35 infants with poor outcome. Prematurity was the most powerful factor in those born before 27.9 weeks' gestation, while oligohydramnios was the most powerful factor in those born at 27.9 weeks or after. The rate of poor outcome in infants born before 25.1 weeks, between 25.1 and 27.9 weeks, at 27.9 weeks or after with oligohydramnios, at 27.9 weeks or after without oligohydramnios, was 53.9%, 18.2%, 13.6% and 3.2%, respectively.
  
  
  CONCLUSIONS
  Risk stratification based on gestation of 25 weeks, 28 weeks and oligohydramnios may aid in prognosis of severe SGA infants.
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan .
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan .
authors.forename: Nagayoshi
authors.initials: N
authors.lastname: Umehara
authors.affiliation: b Department of Maternal and Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan .
authors.forename: Jun
authors.initials: J
authors.lastname: Sasahara
authors.affiliation: c Department of Maternal and Fetal Medicine, Miyagi Children's Hospital , Sendai , Japan .
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Ozawa
authors.affiliation: d Department of Obstetrics and Gynecology, Showa University , Tokyo , Japan .
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Ichizuka
authors.affiliation: e Department of Obstetrics and Gynecology, Kyorin University , Tokyo , Japan .
authors.forename: Kei
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: f Department of Obstetrics and Gynecology, The Jikei University School of Medicine , Tokyo , Japan .
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Tanemoto
authors.affiliation: g Department of Obstetrics and Gynecology, Kanagawa Children's Medical Center , Yokohama , Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.affiliation: h Department of Obstetrics, Seirei Hamamatsu General Hospital , Hamamatsu , Japan .
authors.forename: Takeshi
authors.initials: T
authors.lastname: Murakoshi
authors.affiliation: i Department of Obstetrics, Hyogo Prefectural Kobe Children's Hospital , Kobe , Japan , and.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kiyoshi
authors.affiliation: j Department of Biostatics, Yokohama City University , Yokohama , Japan.
authors.forename: Mari S
authors.initials: MS
authors.lastname: Oba
authors.affiliation: b Department of Maternal and Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health , Osaka , Japan .
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.affiliation: a Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo , Japan .
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
mesh_terms: D000328:Adult; D001034:Apgar Score; D015331:Cohort Studies; D003663:Decision Trees; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D020300:Intracranial Hemorrhages / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D007969:Leukomalacia, Periventricular / Q000453:epidemiology; D016104:Oligohydramnios / Q000453:epidemiology; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment
keywords: Oligohydramnios; SGA; prognosis; risk stratification