title: A comparison of portal vein embolization with poly(2-hydroxyethylmethacrylate) and a histoacryl/lipiodol mixture in patients scheduled for extended right hepatectomy.
abstract: To determine whether PHEMA [poly(2-hydroxyethylmethacrylate)] is suitable for portal vein embolization in patients scheduled to right hepatectomy and whether it is as effective as the currently used agent (a histoacryl/lipiodol mixture). Two groups of nine patients each scheduled for extended right hepatectomy for primary or secondary hepatic tumor, had right portal vein embolization in an effort to induce future liver remnant (FLR) hypertrophy. One group had embolization with PHEMA, the other one with the histoacryl/lipiodol mixture. In all patients, embolization was performed using the right retrograde transhepatic access. Embolization was technically successful in all 18 patients, with no complication related to the embolization agent. Eight patients of either group developed FLR hypertrophy allowing extended right hepatectomy. Likewise, one patient in each group had recanalization of a portal vein branch. Histology showed that both embolization agents reach the periphery of portal vein branches, with PHEMA penetrating somewhat deeper into the periphery. PHEMA has been shown to be an agent suitable for embolization in the portal venous system comparable with existing embolization agent (histoacryl/lipiodol mixture).
authors.affiliation: Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. Jan.Peregrin@seznam.cz.
authors.forename: J H
authors.initials: JH
authors.lastname: Peregrin
authors.forename: R
authors.initials: R
authors.lastname: Janoušek
authors.forename: D
authors.initials: D
authors.lastname: Kautznerová
authors.forename: M
authors.initials: M
authors.lastname: Oliverius
authors.forename: E
authors.initials: E
authors.lastname: Sticová
authors.forename: M
authors.initials: M
authors.lastname: Přádný
authors.forename: J
authors.initials: J
authors.lastname: Michálek
mesh_terms: D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods*; D004659:Enbucrilate / Q000494:pharmacology / Q000627:therapeutic use; D004998:Ethiodized Oil / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology / Q000627:therapeutic use*; D011169:Portal Vein / Q000187:drug effects*
chemical_list: D011102:Polyhydroxyethyl Methacrylate; D004998:Ethiodized Oil; D004659:Enbucrilate