title: ENDOCRINOLOGY AND ADOLESCENCE: Osteoporosis in children: diagnosis and management.
abstract: Osteoporosis in children can be primary or secondary due to chronic disease. Awareness among paediatricians is vital to identify patients at risk of developing osteoporosis. Previous fractures and backaches are clinical predictors, and low cortical thickness and low bone density are radiological predictors of fractures. Osteogenesis Imperfecta (OI) is a rare disease and should be managed in tertiary paediatric units with the necessary multidisciplinary expertise. Modern OI management focuses on functional outcomes rather than just improving bone mineral density. While therapy for OI has improved tremendously over the last few decades, this chronic genetic condition has some unpreventable, poorly treatable and disabling complications. In children at risk of secondary osteoporosis, a high degree of suspicion needs to be exercised. In affected children, further weakening of bone should be avoided by minimising exposure to osteotoxic medication and optimising nutrition including calcium and vitamin D. Early intervention is paramount. However, it is important to identify patient groups in whom spontaneous vertebral reshaping and resolution of symptoms occur to avoid unnecessary treatment. Bisphosphonate therapy remains the pharmacological treatment of choice in both primary and secondary osteoporosis in children, despite limited evidence for its use in the latter. The duration and intensity of treatment remain a concern for long-term safety. Various new potent antiresorptive agents are being studied, but more urgently required are studies using anabolic medications that stimulate bone formation. More research is required to bridge the gaps in the evidence for management of paediatric osteoporosis.
authors.affiliation: Department of Endocrinology and DiabetesBirmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
authors.forename: Vrinda
authors.initials: V
authors.lastname: Saraff
authors.affiliation: Department of Endocrinology and DiabetesBirmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK wolfgang.hogler@bch.nhs.uk.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Högler
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000856:Anorexia Nervosa / Q000150:complications; D000927:Anticonvulsants / Q000009:adverse effects; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000627:therapeutic use*; D002648:Child; D004164:Diphosphonates / Q000627:therapeutic use*; D019468:Disease Management; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D044342:Malnutrition / Q000150:complications; D010013:Osteogenesis Imperfecta / Q000175:diagnosis / Q000628:therapy; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D058866:Osteoporotic Fractures / Q000209:etiology / Q000517:prevention & control*; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D004164:Diphosphonates; D005938:Glucocorticoids; D014807:Vitamin D