title: Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy.
abstract: The purpose of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal-type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery ± radiotherapy (RT).
  
  
  
  Patients with ITAC who underwent endoscopic surgery ± RT at 2 tertiary centers were retrospectively reviewed. Overall survival (OS) and event-free survival were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed.
  
  
  
  One hundred-sixty-nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five-year OS and event-free survival were 68.9% and 63.6%, respectively. Advanced pT classification, high-grade, and positive surgical margins were independently predictive of poor survival.
  
  
  
  Endoscopic surgery ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E996-E1003, 2016.
authors.affiliation: Unit of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Nicolai
authors.affiliation: Unit of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Schreiber
authors.affiliation: Unit of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bolzoni Villaret
authors.affiliation: Unit of Otorhinolaryngology, University of Brescia, Brescia, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Lombardi
authors.affiliation: Unit of Pathology, University of Brescia, Brescia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Morassi
authors.affiliation: Unit of Epidemiology and Public Health, University of Brescia, Brescia, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Raffetti
authors.affiliation: Unit of Epidemiology and Public Health, University of Brescia, Brescia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Donato
authors.affiliation: Unit of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Battaglia
authors.affiliation: Unit of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Turri-Zanoni
authors.affiliation: Unit of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bignami
authors.affiliation: Unit of Otorhinolaryngology, Insubria University, Varese, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Castelnuovo
mesh_terms: D000230:Adenocarcinoma / Q000628:therapy*; D000368:Aged; D018572:Disease-Free Survival; D004724:Endoscopy; D005005:Ethmoid Sinus / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies
keywords: endoscopic surgery; endoscopy; ethmoid; intestinal-type adenocarcinoma; sinonasal tumors