title: Early Dengue Virus Infection in Human Skin: A Cycle of Inflammation and Infectivity.
abstract: Early events during dengue virus (DENV) infection remain poorly understood. In this issue, Schaeffer and colleagues employ ex vivo human skin cells to investigate viral infection. They show that skin-resident immune cells are infected by DENV and that their infectability is increased in the inflammatory skin conditions (especially those in which IL-4 is released) that accompany the mosquito bites transmitting the virus.
authors.affiliation: Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
authors.forename: Matthew O
authors.initials: MO
authors.lastname: Ivory
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
authors.forename: James C
authors.initials: JC
authors.lastname: Birchall
authors.affiliation: Departments of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, Cardiff University and University Hospital of Wales, Heath Park, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
authors.forename: Vincent
authors.initials: V
authors.lastname: Piguet
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology*; D003716:Dengue Virus / Q000472:pathogenicity*; D000078404:Epidermal Cells; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism*; D017193:Skin Diseases, Viral / Q000378:metabolism*
chemical_list: D015847:Interleukin-4