title: Molecular drivers of lobular carcinoma in situ.
abstract: Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecules, such as PIK3CA and c-src, are consistently altered in LCIS. This review focuses on the molecular drivers of lobular carcinoma, a more complete understanding of which may give perspective on which LCIS lesions progress, and which will not, thus having immense clinical implications.
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. logangre@pitt.edu.|Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. logangre@pitt.edu.
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Logan
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. dabbdj@upmc.edu.|Department of Pathology, Magee-Womens Hospital, Pittsburgh, PA, 15213, USA. dabbdj@upmc.edu.
authors.forename: David J
authors.initials: DJ
authors.lastname: Dabbs
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. lucaspc@upmc.edu.|Department of Pathology, Magee-Womens Hospital, Pittsburgh, PA, 15213, USA. lucaspc@upmc.edu.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Lucas
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. jankowitzr@upmc.edu.|Division of Medical Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. jankowitzr@upmc.edu.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Jankowitz
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. browndd2@upmc.edu.|Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. browndd2@upmc.edu.
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Brown
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. clarkbz@upmc.edu.|Department of Pathology, Magee-Womens Hospital, Pittsburgh, PA, 15213, USA. clarkbz@upmc.edu.
authors.forename: Beth Z
authors.initials: BZ
authors.lastname: Clark
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. oesterreichs@upmc.edu.|Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. oesterreichs@upmc.edu.
authors.forename: Steffi
authors.initials: S
authors.lastname: Oesterreich
authors.affiliation: Womens Cancer Research Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, 15213, USA. mcauliffepf@upmc.edu.|Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. mcauliffepf@upmc.edu.
authors.forename: Priscilla F
authors.initials: PF
authors.lastname: McAuliffe
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D002278:Carcinoma in Situ; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011379:Prognosis; D015398:Signal Transduction