title: FibroScan predicts ascites after liver resection for hepatitis B virus-related hepatocellular carcinoma: A prospective cohort study.
abstract: OBJECTIVE
  To assess the correlation of preoperative FibroScan value and postoperative ascites in patients undergoing liver resection for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC).
  
  
  METHODS
  A prospective study group of consecutive HBV-related HCC patients considered eligible for liver resection was conducted from 2012 to 2014 (N = 77). Liver stiffness measured by FibroScan was administrated to all patients. Patient's pre- and intra-operative variables were prospectively collected.
  
  
  RESULTS
  FibroScan was successfully performed in 75 patients. Postoperative ascites was observed in 13 patients. Univariate analyses suggested tumor size, high preoperative hepatitis B viral load, intraoperative blood loss, major hepatectomy and FibroScan value were potential risk factors for postoperative ascites. However, in multivariate analysis, only FibroScan value (OR = 1.506, 95%CI = 1.21-1.87) showed prognostic power. The best cut-off value of FibroScan value to predict postoperative ascites was 15.6 kpa with a sensitivity of 76.9% and a specificity of 98.4%. The corresponding area under the receiver operating curve was 0.902.
  
  
  CONCLUSIONS
  FibroScan value was a reliable surrogate marker for predicting postoperative ascites should be routinely performed in patients with HBV-related HCC undergoing liver resection.
authors.affiliation: Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.affiliation: Division of Ultrasonography, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: ccwentianfu@sohu.com.
authors.forename: Tian-Fu
authors.initials: TF
authors.lastname: Wen
authors.affiliation: Division of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, China.
authors.forename: Lu-Nan
authors.initials: LN
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000601:surgery / Q000821:virology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve
keywords: Ascites; FibroScan; Hepatocellular carcinoma; Liver resection