title: Design, Degradation Mechanism and Long-Term Cytotoxicity of Poly(L-lactide) and Poly(Lactide-co-ϵ-Caprolactone) Terpolymer Film and Air-Spun Nanofiber Scaffold.
abstract: Degradable nanofiber scaffold is known to provide a suitable, versatile and temporary structure for tissue regeneration. However, synthetic nanofiber scaffold must be properly designed to display appropriate tissue response during the degradation process. In this context, this publication focuses on the design of a finely-tuned poly(lactide-co-ϵ-caprolactone) terpolymer (PLCL) that may be appropriate for vascular biomaterials applications and its comparison with well-known semi-crystalline poly(l-lactide) (PLLA). The degradation mechanism of polymer film and nanofiber scaffold and endothelial cells behavior cultured with degradation products is elucidated. The results highlights benefits of using PLCL terpolymer as vascular biomaterial compared to PLLA.
authors.affiliation: Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval, 1065, avenue de la Médecine, Québec City, Canada, G1V 0A6.|Axe Médecine Régénératrice, Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10, rue de l'Espinay, Québec City, Canada, G1L 3L5.|Laboratoire de Physique et Mécanique Textile, Université de Haute Alsace, École Nationale Supérieure d'Ingénieurs du Sud Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, France.
authors.forename: Gad
authors.initials: G
authors.lastname: Sabbatier
authors.affiliation: Department of Mining-Metallurgy Engineering and Materials Science, School of Engineering, University of the Basque Country (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao, Spain.
authors.forename: Aitor
authors.initials: A
authors.lastname: Larrañaga
authors.affiliation: Axe Médecine Régénératrice, Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10, rue de l'Espinay, Québec City, Canada, G1L 3L5.
authors.forename: Andrée-Anne
authors.initials: AA
authors.lastname: Guay-Bégin
authors.affiliation: Department of Mining-Metallurgy Engineering and Materials Science, School of Engineering, University of the Basque Country (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernandez
authors.affiliation: Laboratoire de Physique et Mécanique Textile, Université de Haute Alsace, École Nationale Supérieure d'Ingénieurs du Sud Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Diéval
authors.affiliation: Laboratoire de Physique et Mécanique Textile, Université de Haute Alsace, École Nationale Supérieure d'Ingénieurs du Sud Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Durand
authors.affiliation: Department of Mining-Metallurgy Engineering and Materials Science, School of Engineering, University of the Basque Country (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao, Spain.
authors.forename: Jose-Ramon
authors.initials: JR
authors.lastname: Sarasua
authors.affiliation: Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval, 1065, avenue de la Médecine, Québec City, Canada, G1V 0A6. gaetan.laroche@gmn.ulaval.ca.|Axe Médecine Régénératrice, Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10, rue de l'Espinay, Québec City, Canada, G1L 3L5. gaetan.laroche@gmn.ulaval.ca.
authors.forename: Gaétan
authors.initials: G
authors.lastname: Laroche
mesh_terms: D002152:Calorimetry, Differential Scanning; D002448:Cell Adhesion / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002850:Chromatography, Gel; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008970:Molecular Weight; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000494:pharmacology*; D012501:Saphenous Vein / Q000166:cytology; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011091:Polyesters; C033616:poly(lactide); C062968:lactide-caprolactone copolymer
keywords: Poly(lactide-co-ϵ-caprolactone); biodegradable; biomaterials; nanofibers; polylactides