title: Subjective cognitive concerns, amyloid-β, and neurodegeneration in clinically normal elderly.
abstract: OBJECTIVE
  To determine whether neuroimaging biomarkers of amyloid-β (Aβ) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals.
  
  
  METHODS
  A total of 257 participants underwent Pittsburgh compound B PET, PET with fluorodeoxyglucose (18)F, and structural MRI, as well as a battery of neuropsychological measures including several questionnaires regarding SCC. Individuals were classified into 4 biomarker groups: biomarker negative (Aβ-/ND-), amyloidosis alone (Aβ+/ND-), amyloidosis plus ND (Aβ+/ND+), and ND alone (Aβ-/ND+).
  
  
  RESULTS
  Both Aβ and ND were independently associated with greater SCC controlling for objective memory performance. By contrast, neither Aβ nor ND was associated with objective memory performance controlling for SCC. Further examination revealed greater SCC in individuals with Aβ or ND positivity compared to biomarker-negative individuals. In addition, greater SCC predicted Aβ positivity when controlling for ND status.
  
  
  CONCLUSIONS
  When individuals were grouped by biomarker status, those who were positive on Aβ or ND had the highest report of SCC compared to biomarker-negative individuals. Findings were consistent when SCC was used to predict Aβ positivity. Taken together, results suggest that both Aβ and ND are associated with SCC, independent of objective memory performance. Enrichment of individuals with SCC may increase likelihood of Aβ and ND markers in potential participants for secondary prevention trials.
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA. ramariglio@partners.org.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: Amariglio
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Mormino
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Alison C
authors.initials: AC
authors.lastname: Pietras
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Gad A
authors.initials: GA
authors.lastname: Marshall
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Vannini
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Johnson
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.affiliation: From the Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital (R.E.A., A.C.P., G.A.M., P.V., K.A.J., R.A.S., D.M.R.), and the Departments of Neurology (R.E.A., E.C.M., G.A.M., P.V., K.A.J., R.A.S., D.M.R.) and Radiology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Dorene M
authors.initials: DM
authors.lastname: Rentz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000378:metabolism*; D049268:Positron-Emission Tomography
chemical_list: D016229:Amyloid beta-Peptides