title: Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system.
abstract: Herein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP). For this purpose, polyCD was synthesized and characterized, and its biocompatibility was assessed using fibroblast cytotoxicity tests. Moreover, the interactions between the guest PROP molecule and both polyCD and βCD were found to be spontaneous. Subsequently, PROP was encapsulated in uniaxial and coaxial polyCD/PMAA nanofibers. A lower PROP burst effect (reduction of approximately 50%) and higher modulation were observed from the coaxial than from the uniaxial fibers. Thus, the coaxial nanofibers could potentially be a useful strategy for developing a controlled release system for hydrophilic molecules.
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 31270-901 MG, Brazil.
authors.forename: Michele F
authors.initials: MF
authors.lastname: Oliveira
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 31270-901 MG, Brazil.
authors.forename: Diego
authors.initials: D
authors.lastname: Suarez
authors.affiliation: Departamento de Física, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa (UFV), Viçosa, 36570-000 MG, Brazil.
authors.forename: Júlio Cézar Barbosa
authors.initials: JC
authors.lastname: Rocha
authors.affiliation: Departamento de Física, Centro de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa (UFV), Viçosa, 36570-000 MG, Brazil.
authors.forename: Alvaro Vianna Novaes
authors.initials: AV
authors.lastname: de Carvalho Teixeira
authors.affiliation: Departamento de Odontologia Restauradora, Faculdade de Odontologia, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 31270-901 MG, Brazil.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Cortés
authors.affiliation: Instituto de Física e Química, Universidade Federal de Itajubá (UNIFEI), Itajubá, 37500-903 MG, Brazil. Electronic address: fredbsousa@gmail.com.
authors.forename: Frederico B
authors.initials: FB
authors.lastname: De Sousa
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, 31270-901 MG, Brazil.
authors.forename: Rubén D
authors.initials: RD
authors.lastname: Sinisterra
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D002478:Cells, Cultured; D018914:Cells, Immobilized; D002482:Cellulose / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005881:Gingiva / Q000166:cytology / Q000187:drug effects; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003505:Cyclodextrins; D011109:Polymethacrylic Acids; C041953:cyclodextrin polymer; C030613:polymethacrylic acid; D002482:Cellulose
keywords: Drug delivery system; Electrospinning; Poly-cyclodextrin; Polymeric nanofibers; Propranolol