title: Controllable release from high-transition temperature magnetoliposomes by low-level magnetic stimulation.
abstract: High-transition temperature liposomes with embedded coated magnetite nanoparticles were prepared using the thin lipid film hydration method in order to obtain magnetoliposomes not sensitive to temperature increase (at least up to 50°C). Accordingly, drug can be released from such magnetoliposomes using a low-level electromagnetic field as triggering agent, while no delivery would be obtained with temperature increase within the physiological acceptable range. The hypothesized release mechanism involves mechanical stress of the liposome membrane due to nanoparticles oscillations and it is investigated by means of a numerical model evaluated using multiphysics simulations. The carrier content was repetitively released by switching on and off a 20kHz, 60A/m magnetic field. The results indicated high reproducibility of cycle-to-cycle release induced by the magnetic-impelled motions driving to the destabilization of the bilayer rather than the liposome phase transition or the destruction of the liposome structure.
authors.affiliation: Department of Drug Chemistry and Technology, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Romina
authors.initials: R
authors.lastname: Spera
authors.affiliation: Department of Information Engineering, Electronics and Telecommunications, "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Apollonio
authors.affiliation: Department of Information Engineering, Electronics and Telecommunications, "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: Liberti
authors.affiliation: Department of Information Engineering, Electronics and Telecommunications, "Sapienza" University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Paffi
authors.affiliation: Technical Unit of Radiation Biology and Human Health, Enea Research Center, Via Anguillarese 301, 00123 Rome, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Merla
authors.affiliation: Technical Unit of Radiation Biology and Human Health, Enea Research Center, Via Anguillarese 301, 00123 Rome, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Pinto
authors.affiliation: Department of Drug Chemistry and Technology, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy. Electronic address: stefania.petralito@uniroma1.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Petralito
mesh_terms: D000465:Algorithms; D002152:Calorimetry, Differential Scanning; D004553:Electric Conductivity; D006358:Hot Temperature; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D060526:Magnetic Fields; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008956:Models, Chemical; D013053:Spectrophotometry; D055672:Static Electricity; D044366:Transition Temperature
chemical_list: D008055:Lipids; D008081:Liposomes; D058185:Magnetite Nanoparticles
keywords: Alternating magnetic field; Drug delivery; High-transition temperature magnetoliposomes; Stimuli-responsive carriers