title: [Bilateral Optic Disc Edema Secondary to Amiodarone: Manifestation of an Iatrogenic Optic Neuropathy].
abstract: A 69-years-old male patient was treated with amiodarone 200mg/day over the passed two months for atrial fibrillation. He presented a sudden, painless and unilateral visual loss. Ophthalmologic evaluation revealed a bilateral optic disc edema. Neurological examination was otherwise unremarkable. After properly excluding increased intracranial pressure and giant cell arteritis, the main differential diagnosis was between nonarteritic anterior ischemic optic neuropathy and optic neuropathy secondary to amiodarone. The latter diagnosis was favored due to a presence of bilateral and simultaneous optic disc edema, gradual improvement of symptoms after discontinuation of the drug, and, mostly, by persistence of optic disc edema beyond 6 weeks. Of note, an acute presentation of this disorder is common. Amiodarone optic neuropathy is a rare but potentially serious cause of optic nerve dysfunction, and its discontinuation is usually warrant.
authors.affiliation: Serviço de Neurologia. Centro Hospitalar de São João. Porto. Portugal. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Andrade
authors.affiliation: Serviço de Oftalmologia. Centro Hospitalar de São João. Porto. Portugal. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
authors.forename: Olinda
authors.initials: O
authors.lastname: Faria
authors.affiliation: Serviço de Neurologia. Centro Hospitalar de São João. Porto. Portugal. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Guimarães
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D010211:Papilledema / Q000139:chemically induced*
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone