title: Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis.
abstract: BACKGROUND
  Results regarding the association between a-adducin (ADD1) gene and essential hypertension (EH) risk remain inconsistent. Therefore, we performed this meta-analysis to investigate this association.
  
  
  METHODS
  We comprehensively searched published literature from PubMed and Embase. All studies analyzing the association between ADD1 Gly460Trp polymorphism and EH risk were included. Fixed- or random-effects model was used to calculate pooled odds ratio (OR) with 95% confidence interval (CI).
  
  
  RESULTS
  Data synthesis showed an increased risk of EH in T allele variant carriers with Asian descent, for GG vs. TT (OR=0.750, 95%CI: 0.585-0.960; P=0.022), recessive model (OR=1.196, 95%CI: 1.009-1.418; P=0.039), dominant model (OR=0.826, 95%CI: 0.693-0.985; P=0.033), and allelic model (OR=0.859, 95%CI: 0.756-0.964; P=0.01), respectively. However, no statistical differences were observed in Blacks and Caucasians.
  
  
  CONCLUSIONS
  The findings showed the association of the T allele in ADD1 gene with EH susceptibility in Asians. However, well-designed studies involving gene-gene and gene-environment interactions should be considered in future.
authors.affiliation: Unit of General Practice, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Liao
authors.affiliation: Department of Neurology, Cheng Du Military General Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Weiwen
authors.initials: W
authors.lastname: Wang
authors.affiliation: Unit of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Neurology, Cheng Du Military General Hospital, Chengdu, Sichuan, China (mainland).
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Unit of General Practice, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Hua
authors.initials: H
authors.lastname: Dai
authors.affiliation: Unit of General Practice, West China Hospital of Sichuan University, Chengdu, Sichuan, China (mainland).
authors.forename: Yi
authors.initials: Y
authors.lastname: Lei
mesh_terms: D044466:Asian People / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D039781:PubMed; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D000099291:Adducins