title: A Modified One-Stage Early Correction of Blepharophimosis Syndrome Using Tutopatch Slings.
abstract: OBJECTIVE
  To investigate the efficacy of a one-stage early correction of blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), using bovine pericardium derived membrane (TUTOPATCH(®)) for the frontalis suspension.
  
  
  METHODS
  We prospectively studied 12 eyes from 6 patients (median age 14 months) affected by BPES with severe ptosis. All patients were submitted to a one-stage early correction of ptosis (frontalis suspension with TUTOPACH(®)) and telecanthus and epicanthus inversus. Upper margin reflex distance (MRD), nasal inner intercanthal distance (IICD), horizontal fissure length (HFL), and IICD/HFL ratio were evaluated using photographs.
  
  
  RESULTS
  The Wilcoxon signed-rank test showed a statistically significant difference between pre- and post-operative MRD, IICD, HFL, and the IICD/HFL ratio.
  
  
  CONCLUSIONS
  An early TUTOPATCH-assisted frontalis suspension, together with the correction of telecanthus and epicanthus inversus, is an effective procedure for BPES cases with severe ptosis.
authors.affiliation: Institute of Ophthalmology, Policlinico Gemelli, Catholic University of Sacred Heart , Rome , Italy and.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Savino
authors.forename: Erika
authors.initials: E
authors.lastname: Mandarà
authors.forename: Luigi
authors.initials: L
authors.lastname: Calandriello
authors.forename: Anna
authors.initials: A
authors.lastname: Dickmann
authors.forename: Sergio
authors.initials: S
authors.lastname: Petroni
mesh_terms: D016569:Blepharophimosis / Q000601:surgery*; D019882:Blepharoplasty / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012868:Skin Abnormalities / Q000601:surgery*; D013577:Syndrome; D016896:Treatment Outcome; D014564:Urogenital Abnormalities / Q000601:surgery*
keywords: Blepharophimosis-ptosis-epicanthus inversus syndrome; bovine pericardium derived membrane (TUTOPATCH®); eyelid frontalis suspension