title: Thrombospondin-1 and Pathogenesis of Age-Related Macular Degeneration.
abstract: The cardinal features of age-related macular degeneration (AMD) are the accumulation of subretinal debris, subretinal inflammation, neovascularization, and degeneration of the photoreceptors and retinal pigment epithelium (RPE). Thrombospondin-1 (TSP-1) is a major matricellular protein that is physiologically expressed in the RPE and choroid, but severely diminished in eyes with AMD. TSP-1 plays an important role in phagocytosis, potently inhibits neovascularization, and mediates immune suppression and immune privilege. The lack of TSP-1 could have a central role in the pathogenesis of AMD as it is implicated in the major pathways that seem to be deficient in the disease. We here give an overview of the major functions of TSP-1 and how it could intervene in AMD pathogenesis.
authors.affiliation: 1 Sorbonne Universités , UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France .|2 CNRS , UMR_7210, Paris, France .|3 INSERM , U968, Paris, France .
authors.forename: Michael
authors.initials: M
authors.lastname: Housset
authors.affiliation: 1 Sorbonne Universités , UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris, France .|2 CNRS , UMR_7210, Paris, France .|3 INSERM , U968, Paris, France .|4 Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, DHU ViewMaintain, INSERM-DHOS CIC 1423 , Paris, France .
authors.forename: Florian
authors.initials: F
authors.lastname: Sennlaub
mesh_terms: D000818:Animals; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D019700:Thrombospondin 1 / Q000378:metabolism*
chemical_list: D019700:Thrombospondin 1