title: Tubal origin of ovarian endometriosis and clear cell and endometrioid carcinoma.
abstract: Current research has strongly proposed that contrary to prior beliefs, many ovarian epithelial cancers (OECs) do not, as their name suggests, originate in the ovaries. Recent findings regarding both high-grade and low-grade serous carcinomas has implicated the fallopian tube as a cell source for these OECs, but until now, there has been little insight into the cellular source for clear cell and endometrioid carcinomas. In this commentary review article, we aimed to discuss the new findings that support the possible contribution from the fallopian tube in clear cell and endometrioid carcinomas. Specifically, we have provided results that showcased ovarian surface epithelia (OSE) and ovarian epithelial inclusions (OEIs) as having mesothelial and tubal origins and have strongly recognized the secondary müllerian system and the ability for tubal epithelia to implant upon the ovarian surface as contributing to fallopian tube-derived OEIs (F-OEIs). We have provided initial indications of these F-OEIs and their relationship to endometriosis and then clear cell and endometrioid carcinomas and subsequently offer our new proposal of a probable tubal origin. This new proposal is a paradigm that drastically changes the understanding behind the origin of these OECs and has significant clinical implications in the near future.
authors.affiliation: Department of Obstetrics and Gynecology, Henan Provincial People's Hospital Zhengzhou, China ; Department of Pathology, University of Arizona College of Medicine Tucson, AZ.
authors.forename: Yiying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of Arizona College of Medicine Tucson, AZ ; Emory College of Arts and Science, Emory University Atlanta, GA.
authors.forename: Maggie
authors.initials: M
authors.lastname: Mang
authors.affiliation: Department of Obstetrics and Gynecology, Henan Provincial People's Hospital Zhengzhou, China ; Department of Pathology, University of Arizona College of Medicine Tucson, AZ.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University Shandong, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of Arizona College of Medicine Tucson, AZ.
authors.forename: Robert
authors.initials: R
authors.lastname: Klein
authors.affiliation: Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University Shandong, China.
authors.forename: Beihua
authors.initials: B
authors.lastname: Kong
authors.affiliation: Department of Pathology, University of Arizona College of Medicine Tucson, AZ ; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University Shandong, China ; Department of Obstetrics and Gynecology, University of Arizona Tucson, AZ ; Arizona Cancer Center, University of Arizona Tucson, AZ.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zheng
keywords: Fallopian tube; clear cell carcinoma; endometrioid carcinoma; endometriosis; secondary müllerian system