title: Pancreatic cancer stem cells.
abstract: Studies are emerging in support of the cancer stem cells (CSCs) theory which considers that a tiny subset of cancer cells is exclusively responsible for the initiation and malignant behavior of a cancer. This cell population, also termed CSCs, possesses the capacity both to self-renew, producing progeny that have the identical tumorigenic potential, and to differentiate into the bulk of cancer cells, helping serve the formation of the tumor entities, which, altogether, build the hierarchically organized structure of a cancer. In this review, we try to articulate the complicated signaling pathways regulating the retention of the characteristics of pancreatic CSCs, and in the wake of which, we seek to offer insights into the CSCs-relevant targeted therapeutics which are, in the meantime, confronted with bigger challenges than ever.
authors.affiliation: Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai, 200233, China.
authors.forename: Ya-Yun
authors.initials: YY
authors.lastname: Zhu
authors.affiliation: Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai, 200233, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Yuan
keywords: CSC-targeted therapeutic; Pancreatic cancer; cancer stem cells; microRNA; signaling pathway