title: Preclinical Murine Models for Lung Cancer: Clinical Trial Applications.
abstract: Murine models for the study of lung cancer have historically been the backbone of preliminary preclinical data to support early human clinical trials. However, the availability of multiple experimental systems leads to debate concerning which model, if any, is best suited for a particular therapeutic strategy. It is imperative that these models accurately predict clinical benefit of therapy. This review provides an overview of the current murine models used to study lung cancer and the advantages and limitations of each model, as well as a retrospective evaluation of the uses of each model with respect to accuracy in predicting clinical benefit of therapy. A better understanding of murine models and their uses, as well as their limitations may aid future research concerning the development and implementation of new targeted therapies and chemotherapeutic agents for lung cancer.
authors.affiliation: Departments of Oncology/Medicine, University of Calgary, 1331 29 Street NW, Calgary, AB, Canada T2N 4N2.
authors.forename: Amelia
authors.initials: A
authors.lastname: Kellar
authors.affiliation: Departments of Oncology/Medicine, University of Calgary, 1331 29 Street NW, Calgary, AB, Canada T2N 4N2.
authors.forename: Cay
authors.initials: C
authors.lastname: Egan
authors.affiliation: Departments of Oncology/Medicine, University of Calgary, 1331 29 Street NW, Calgary, AB, Canada T2N 4N2.
authors.forename: Don
authors.initials: D
authors.lastname: Morris
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D051379:Mice
chemical_list: D000970:Antineoplastic Agents