title: Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.
abstract: Nonalcoholic fatty liver disease (NAFLD) progresses to nonalcoholic steatohepatitis, ultimately leading to cirrhosis and liver cancer. It is important to prevent this progression during the initial stages of hepatic fatty degeneration. Maltitol is a polyol produced by the hydrogenation of maltose. We investigated the efficacy of maltitol for treating hepatic fatty degeneration in C57BL/6 male mice using a high-fat diet model. Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia. With maltitol intake, sterol regulatory element-binding protein 1c (SREBP1c) mRNA expression was significantly decreased, and farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARα), and hydroxymethylglutaryl-Co reductase expressions were significantly higher in the liver. The increase in SREBP1c and suppression of FXR and PPARα expressions are correlated with NAFLD. Our results suggest that maltitol may prevent steatosis of NAFLD with a high-fat diet.
authors.affiliation: 1 Department of Integrative Medicine, Graduate School of Medicine, Osaka University , Osaka, Japan .
authors.forename: Hayato
authors.initials: H
authors.lastname: Urushima
authors.affiliation: 1 Department of Integrative Medicine, Graduate School of Medicine, Osaka University , Osaka, Japan .
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Sanada
authors.affiliation: 1 Department of Integrative Medicine, Graduate School of Medicine, Osaka University , Osaka, Japan .
authors.forename: Miki
authors.initials: M
authors.lastname: Sakaue
authors.affiliation: 2 Sumitomo Hospital , Osaka, Japan .
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
authors.affiliation: 1 Department of Integrative Medicine, Graduate School of Medicine, Osaka University , Osaka, Japan .
authors.forename: Toshinori
authors.initials: T
authors.lastname: Ito
authors.affiliation: 1 Department of Integrative Medicine, Graduate School of Medicine, Osaka University , Osaka, Japan .
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D015870:Gene Expression / Q000187:drug effects; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D006937:Hypercholesterolemia / Q000517:prevention & control; D006943:Hyperglycemia / Q000517:prevention & control; D008099:Liver / Q000737:chemistry; D008297:Male; D008320:Maltose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology* / Q000517:prevention & control*; D047493:PPAR alpha / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics; D013402:Sugar Alcohols / Q000008:administration & dosage* / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D006903:Hydroxymethylglutaryl CoA Reductases; D008320:Maltose; D047493:PPAR alpha; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D051780:Sterol Regulatory Element Binding Protein 1; D013402:Sugar Alcohols; D000099150:Receptor, Farnesoid X-Activated; C010745:maltitol
keywords: FXR; PPARα; SREBP1c; hepatic fatty degeneration; maltitol; polyol