title: Dysfunction of the ubiquitin-proteasome system in atherosclerotic cardiovascular disease.
abstract: The ubiquitin-proteasome system (UPS) is an integral part of the protein metabolism and protein quality control in eukaryotic cells. It is involved in a number of biological processes of significance for vascular biology and pathology such as oxidative stress, inflammation, foam cell formation, and apoptosis. This review summarizes both indirect and direct lines of evidence for a role of the UPS in atherosclerosis from the initiation to the progression and complication stage and concludes with a future perspective.
authors.affiliation: The Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, MN, USA.
authors.forename: Feilong
authors.initials: F
authors.lastname: Wang
authors.affiliation: The Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, MN, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Lerman
authors.affiliation: The Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Rochester, MN, USA.
authors.forename: Joerg
authors.initials: J
authors.lastname: Herrmann
keywords: Atherosclerosis; inflammation; oxidative stress; proteasome; ubiquitin