title: Patients with chronic rhinosinusitis and simultaneous bronchial asthma suffer from significant extraesophageal reflux.
abstract: BACKGROUND
  The aim of this study was to determine the severity of extraesophageal reflux (EER) in patients with various degrees of chronic rhinosinusitis (CRS), and particularly in patients with simultaneous bronchial asthma.
  
  
  METHODS
  Patients with different severity of CRS were invited to participate in the study. Group I consisted of patients with CRS without nasal polyps or bronchial asthma; group II consisted of patients with CRS with nasal polyps but without bronchial asthma; group III consisted of patients with CRS with nasal polyps and bronchial asthma. The age, gender, Reflux Symptom Index, severity of EER evaluated using the Restech system, and number of previous functional endoscopic sinus surgeries (FESSs) were compared between groups.
  
  
  RESULTS
  A total of 90 patients (30 in each group) were recruited for the study. Pathological EER was significantly often present in group III when compared with group I and group II in all parameters analyzed (RYAN score, number of EER episodes, total percentage of time below pH 5.5). Furthermore, patients from group III had undergone more surgeries in the past.
  
  
  CONCLUSIONS
  Patients with CRS with nasal polyps and simultaneous bronchial asthma suffer from significant EER. Antireflux therapy can be recommended for these patients. However, the effect has to be confirmed in further studies.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Ostrava, Ostrava, Czech Republic.|Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Karol
authors.initials: K
authors.lastname: Zeleník
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Ostrava, Ostrava, Czech Republic.|Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Matoušek
authors.affiliation: Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.|Department of Gastroenterology, Vítkovice Hospital, Ostrava, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Formánek
authors.affiliation: Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.|Department of Gastroenterology, Vítkovice Hospital, Ostrava, Czech Republic.
authors.forename: Ondřej
authors.initials: O
authors.lastname: Urban
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Ostrava, Ostrava, Czech Republic.|Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Komínek
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology*; D002170:Canada; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000453:epidemiology*; D015995:Prevalence; D012220:Rhinitis / Q000453:epidemiology*; D012720:Severity of Illness Index; D012852:Sinusitis / Q000453:epidemiology*; D055815:Young Adult
keywords: antireflux therapy; bronchial asthma; chronic rhinosinusitis; extraesophageal reflux; oropharyngeal pH monitoring