title: [Chemerin: a pro-inflammatory adipokine involved in the reproduction function?].
abstract: Chemerin is a pro-inflammatory adipokine secreted and expressed predominantly by adipocytes. Chemerin is initially involved in the regulation of the immune system, the adipogenesis and the energy metabolism. However, several recent studies show that this adipokine and its receptors are present in the gonads. In vitro, chemerin reduces steroidogenesis in ovarian and testicular cells in rodents and humans. Chemerin and its receptors are also present in the placenta. Chemerin plays an important role in the regulation of fetal and maternal metabolism, fetal growth and metabolic homeostasis during pregnancy. This review describes the role of chemerin in metabolism and reproduction.
authors.affiliation: Unité de physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-université François Rabelais de Tours, 37380 Nouzilly, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Reverchon
authors.affiliation: Unité de physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-université François Rabelais de Tours, 37380 Nouzilly, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Ramé
authors.affiliation: Unité de physiologie de la reproduction et des comportements, UMR 6175 INRA-CNRS-université François Rabelais de Tours, 37380 Nouzilly, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Dupont
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D050156:Adipogenesis / Q000502:physiology; D054392:Adipokines / Q000502:physiology*; D000818:Animals; D018925:Chemokines / Q000502:physiology*; D002630:Chemotactic Factors / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006066:Gonads / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation / Q000503:physiopathology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology; D051379:Mice; D008958:Models, Molecular; D009765:Obesity / Q000503:physiopathology; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011499:Protein Processing, Post-Translational; D051381:Rats; D019707:Receptors, Chemokine / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*
chemical_list: D054392:Adipokines; D018925:Chemokines; D002630:Chemotactic Factors; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; C560738:Rarres2 protein, rat; D019707:Receptors, Chemokine; C523686:chemerin protein, mouse