title: Abnormal metabolic pattern associated with cognitive impairment in Parkinson's disease: a validation study.
abstract: Cognitive deficits in Parkinson's disease (PD) have been associated with a specific metabolic covariance pattern. Although the expression of this PD cognition-related pattern (PDCP) correlates with neuropsychological performance, it is not known whether the PDCP topography is reproducible across PD populations. We therefore sought to identify a PDCP topography in a new sample comprised of 19 Dutch PD subjects. Network analysis of metabolic scans from these individuals revealed a significant PDCP that resembled the original network topography. Expression values for the new PDCP correlated (P=0.001) with executive dysfunction on the Frontal Assessment Battery (FAB). Subject scores for the new PDCP correlated (P<0.001) with corresponding values for the original pattern, which also correlated (P<0.005) with FAB scores in this patient group. For further validation, subject scores for the new PDCP were computed in an independent group of 86 American PD patients. In this cohort, subject scores for the new and original PDCP topographies were closely correlated (P<0.001); significant correlations between pattern expression and cognitive performance (P<0.05) were observed for both PDCP topographies. These findings suggest that the PDCP is a replicable imaging marker of PD cognitive dysfunction.
authors.affiliation: Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Sanne K
authors.initials: SK
authors.lastname: Meles
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: Chris C
authors.initials: CC
authors.lastname: Tang
authors.affiliation: Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Teune
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Rudi A
authors.initials: RA
authors.lastname: Dierckx
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Dhawan
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mattis
authors.affiliation: Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Klaus L
authors.initials: KL
authors.lastname: Leenders
authors.affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography; D011859:Radiography