title: Prolonged remission in a child with chronic myeloid leukemia following Parvo virus B19 (B19V) infection.
abstract: Parvovirus B19 (B19V) has been associated with a wide spectrum of clinico-pathological disorders in human beings depending upon the host immunity. The present report describes a child with chronic myeloid leukemia ( CML) on hydroxyurea in haematological remission, who developed profound erythroid suppression following B19V infection requiring multiple transfusions and withdrawal of hydroxyurea. Despite being off-therapy the child remained in complete clinical and haematological remission till anti B19V antibodies appeared. This case illustrates the ability of B19V infection in suppressing neoplastic myeloid clone, a phenomenon not described earlier.
authors.affiliation: Department of Pediatrics, Division of Pediatric Hematology-Oncology, King George's Medical University, Lucknow, Uttar Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: N Roy
authors.initials: NR
authors.lastname: Moulik
authors.forename: J
authors.initials: J
authors.lastname: Kishore
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Jain
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D006801:Humans; D007181:Inclusion Bodies, Viral; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology*; D008297:Male; D008853:Microscopy; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D012075:Remission, Spontaneous
chemical_list: D000914:Antibodies, Viral