title: Immunological, Viral, Environmental, and Individual Factors Modulating Lung Immune Response to Respiratory Syncytial Virus.
abstract: Respiratory syncytial virus is a worldwide pathogen agent responsible for frequent respiratory tract infections that may become severe and potentially lethal in high risk infants and adults. Several studies have been performed to investigate the immune response that determines the clinical course of the infection. In the present paper, we review the literature on viral, environmental, and host factors influencing virus response; the mechanisms of the immune response; and the action of nonimmunological factors. These mechanisms have often been studied in animal models and in the present review we also summarize the main findings obtained from animal models as well as the limits of each of these models. Understanding the lung response involved in the pathogenesis of these respiratory infections could be useful in improving the preventive strategies against respiratory syncytial virus.
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
authors.forename: Silvia
authors.identifier: 0000-0002-1052-8189
authors.initials: S
authors.lastname: Vandini
authors.affiliation: Pediatrics and Neonatology Unit, Imola Hospital, Via Montericco 4, 40026 Imola, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bottau
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Faldella
authors.affiliation: Pediatrics and Neonatology Unit, Imola Hospital, Via Montericco 4, 40026 Imola, Italy.
authors.forename: Marcello
authors.identifier: 0000-0002-2586-314X
authors.initials: M
authors.lastname: Lanari
mesh_terms: D006801:Humans; D007113:Immunity, Innate; D008168:Lung / Q000473:pathology / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000473:pathology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology