title: A near-infrared emissive Al(3+) sensing platform for specific detection in solution, cells and probing DNase activity.
abstract: A new tricarbocyanine-based chemosensor exhibited a dramatic Al(3+)-specific fluorescence turn-on response in the near-infrared (NIR) region. The receptor was found to be highly selective towards Al(3+) over other metal ions in physiological condition. The sensor was non-toxic and could thus be employed as an imaging probe for detecting intracellular Al(3+) in live cells. Interestingly, upon interaction with DNA in solution, the L-Al(3+) ensemble rendered tracking of DNase activity in solution through a systematic reduction in the fluorescence emission intensity.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Barun K
authors.initials: BK
authors.lastname: Datta
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Durairaj
authors.initials: D
authors.lastname: Thiyagarajan
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.
authors.forename: Chirantan
authors.initials: C
authors.lastname: Kar
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781039, India. Electronic address: aramesh@iitg.ernet.in.
authors.forename: Aiyagari
authors.initials: A
authors.lastname: Ramesh
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. Electronic address: gdas@iitg.ernet.in.
authors.forename: Gopal
authors.initials: G
authors.lastname: Das
mesh_terms: D000535:Aluminum / Q000032:analysis*; D000818:Animals; D002417:Cattle; D003851:Deoxyribonucleases / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D057230:Limit of Detection; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D012996:Solutions; D000535:Aluminum; D003851:Deoxyribonucleases
keywords: Al(3+) sensor; Cell imaging; DNase activity sensing; Near-infrared fluorescence