title: In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway.
abstract: Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.
authors.affiliation: Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
authors.forename: Marcia F
authors.initials: MF
authors.lastname: da Silva
authors.affiliation: Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
authors.forename: Alexandre Y
authors.initials: AY
authors.lastname: Saito
authors.affiliation: Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
authors.forename: Valnice J
authors.initials: VJ
authors.lastname: Peres
authors.affiliation: Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil.
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Oliveira
authors.affiliation: Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil amkatzin@icb.usp.br.
authors.forename: Alejandro M
authors.initials: AM
authors.lastname: Katzin
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D053898:Biosynthetic Pathways / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D004347:Drug Interactions; D005578:Fosfomycin / Q000031:analogs & derivatives / Q000494:pharmacology; D008288:Malaria / Q000188:drug therapy; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism; D000068296:Risedronic Acid / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology; D013729:Terpenes / Q000378:metabolism*; D014233:Tricarboxylic Acids / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D019086:Bridged Bicyclo Compounds, Heterocyclic; D012717:Sesquiterpenes; D013729:Terpenes; D014233:Tricarboxylic Acids; C075117:squalestatin 1; D005578:Fosfomycin; C024640:fosmidomycin; D000068296:Risedronic Acid; C037055:nerolidol