title: Reduced noise susceptibility in littermate offspring from heterozygous animals of the German waltzing guinea pig.
abstract: The German waltzing guinea pig is a spontaneously mutated strain with severe auditory and vestibular impairment caused by a so far unknown genetic mutation. The animals are born deaf and show a circling behavior. The heterozygote animals of this guinea pig strain have functionally normal hearing and balance. However, these animals have, in earlier studies, shown an increased resistance to noise compared with normal wild-type guinea pigs. In the present study, we explored the functional hearing with auditory brainstem response thresholds before and at different time points after noise exposure. Symptom-free littermates from heterozygote couples of the German waltzing guinea pigs were exclusively used for the study, which, after the hearing test, were sent back for breeding to confirm their genotype (i.e. heterozygote or normal). The aim of this paper was to ascertain that the previously shown reduced susceptibility to noise trauma in the heterozygote animals of the German waltzing guinea pig was also evident when littermates were used as control animals. The findings are important for further analysis of the heterozygote animals of this strain and for future investigations of the underlying mechanisms behind the diverse susceptibility to exposures of loud sound.
authors.affiliation: aUnit of Audiology, Department of Clinical Science, Intervention and Technology, Karolinska Institute bDepartment of Neuroscience, Karolinska Institutet cDepartment of Audiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Åsa
authors.initials: Å
authors.lastname: Skjönsberg
authors.forename: Paula
authors.initials: P
authors.lastname: Mannström
mesh_terms: D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001947:Breeding; D004198:Disease Susceptibility; D016057:Evoked Potentials, Auditory, Brain Stem / Q000235:genetics*; D005260:Female; D006168:Guinea Pigs / Q000235:genetics*; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006579:Heterozygote; D008297:Male; D019956:Stereotypic Movement Disorder / Q000235:genetics; D013997:Time Factors