title: Nramp1 and Other Transporters Involved in Metal Withholding during Infection.
abstract: During the course of infection, many natural defenses are set up along the boundaries of the host-pathogen interface. Key among these is the host response to withhold metals to restrict the growth of invading microbes. This simple act of nutritional warfare, starving the invader of an essential element, is an effective means of limiting infection. The physiology of metal withholding is often referred to as "nutritional immunity," and the mechanisms of metal transport that contribute to this host response are the focus of this review.
authors.affiliation: From the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 wessling@hsph.harvard.edu.
authors.forename: Marianne
authors.initials: M
authors.lastname: Wessling-Resnick
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism; D001692:Biological Transport; D027682:Cation Transport Proteins / Q000502:physiology*; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007501:Iron / Q000378:metabolism; D008345:Manganese / Q000378:metabolism; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D027682:Cation Transport Proteins; D007501:Iron; D008345:Manganese; D000099173:Natural Resistance-associated Macrophage Protein 1
keywords: DMT1; Slc11a1; Slc11a2; Slc30a10; Slc39a14; Slc40a1; Zip14; ferroportin; hypermanganesemia; iron; manganese; membrane protein; metal homeostasis; nutritional immunity; transport