title: Urinary 8-iso-prostaglandin F2α as a marker of metabolic risks in the general Japanese population: The ROAD study.
abstract: OBJECTIVE
  To determine whether 8-iso-prostaglandin F2α (8-iso-PGF2α) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia].
  
  
  METHODS
  This was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2α levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis.
  
  
  RESULTS
  8-iso-PGF2α was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2α level in participants aged ≤50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2α level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged ≥71 years, 8-iso-PGF2α was significantly associated with a greater number of MetS risks with higher IGT cut-offs.
  
  
  CONCLUSIONS
  Urinary 8-iso-PGF2α can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people.
authors.affiliation: Department of Public Health, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Kanae
authors.initials: K
authors.lastname: Mure
authors.affiliation: Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
authors.affiliation: Department of Public Health, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Marowa
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.affiliation: Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.affiliation: Department of Public Health, Wakayama Medical University School of Medicine, Wakayama, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Takeshita
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000652:urine; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000652:urine*; D008875:Middle Aged; D018384:Oxidative Stress; D012044:Regression Analysis; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost