title: Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art.
abstract: Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application.
authors.affiliation: a Department of Pharmaceutics and.
authors.forename: Mohammad Zaki
authors.initials: MZ
authors.lastname: Ahmad
authors.affiliation: b Department of Clinical Pharmacy , College of Pharmacy, Najran University , Najran , Kingdom of Saudi Arabia .
authors.forename: Saad Ahmed
authors.initials: SA
authors.lastname: Alkahtani
authors.affiliation: c Nanomedicine Research Lab, Faculty of Pharmacy , Jamia Hamdrad , New Delhi , India , and.
authors.forename: Sohail
authors.initials: S
authors.lastname: Akhter
authors.affiliation: c Nanomedicine Research Lab, Faculty of Pharmacy , Jamia Hamdrad , New Delhi , India , and.
authors.forename: Farhan Jalees
authors.initials: FJ
authors.lastname: Ahmad
authors.affiliation: c Nanomedicine Research Lab, Faculty of Pharmacy , Jamia Hamdrad , New Delhi , India , and.
authors.forename: Javed
authors.initials: J
authors.lastname: Ahmad
authors.affiliation: b Department of Clinical Pharmacy , College of Pharmacy, Najran University , Najran , Kingdom of Saudi Arabia .
authors.forename: Mohammad Shabib
authors.initials: MS
authors.lastname: Akhtar
authors.affiliation: b Department of Clinical Pharmacy , College of Pharmacy, Najran University , Najran , Kingdom of Saudi Arabia .
authors.forename: Nehal
authors.initials: N
authors.lastname: Mohsin
authors.affiliation: d Deparment of Pharmacology , College of Pharmacy, Najran University , Najran , Kingdom of Saudi Arabia.
authors.forename: Basel A
authors.initials: BA
authors.lastname: Abdel-Wahab
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003474:Curcumin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods* / Q000639:trends
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D003474:Curcumin
keywords: Cancer; cancer therapy; curcumin; curcumin nanoformulation; curcumin nanomedicine; nanoparticles