title: AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease.
abstract: CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by macrophages in lymphoid and inflamed tissues. The expression of this protein is transcriptionally controlled by LXRs, members of the nuclear receptor family that play major roles in lipid homeostasis. Research undertaken over the last decade has uncovered critical roles of CD5L as a PRR of bacterial and fungal components and in the control of key mechanisms in inflammatory responses, with involvement in processes, such as infection, atherosclerosis, and cancer. In this review, we summarize the current knowledge of CD5L, its roles at the intersection between lipid homeostasis and immune response, and its potential use as a diagnostic biomarker in a variety of diseases, such as TB and liver cirrhosis.
authors.affiliation: *Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Sanjurjo
authors.affiliation: *Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
authors.forename: Gemma
authors.initials: G
authors.lastname: Aran
authors.affiliation: *Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
authors.forename: Nerea
authors.initials: N
authors.lastname: Roher
authors.affiliation: *Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.
authors.forename: Annabel F
authors.initials: AF
authors.lastname: Valledor
authors.affiliation: *Innate Immunity Group, Health Sciences Research Institute Germans Trias i Pujol, Badalona, Spain; Evolutive Immunology Group, Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Nuclear Receptor Group, Department of Physiology and Immunology, School of Biology, University of Barcelona, Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain mrsarrias@igtp.cat.
authors.forename: Maria-Rosa
authors.initials: MR
authors.lastname: Sarrias
mesh_terms: D051017:Apoptosis Regulatory Proteins; D050197:Atherosclerosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology; D050356:Lipid Metabolism / Q000235:genetics / Q000276:immunology; D008103:Liver Cirrhosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D000071518:Liver X Receptors; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D057093:Orphan Nuclear Receptors / Q000235:genetics / Q000276:immunology; D020033:Protein Isoforms / Q000235:genetics / Q000276:immunology; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology
chemical_list: D051017:Apoptosis Regulatory Proteins; C492821:CD5L protein, human; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D020033:Protein Isoforms; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
keywords: SRCR domain; Spα; cancer; macrophage; metabolic disease