title: Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs.
abstract: BACKGROUND
  Azithromycin may be an alternative adjunctive systemic antibiotic in non-surgical periodontal therapy.
  
  
  OBJECTIVE
  This study aims to identify randomized controlled trials evaluating non-surgical periodontal treatment of chronic and/or aggressive periodontitis supplemented with systemically administered azithromycin.
  
  
  METHODS
  A systematic literature search was performed for publications published by 31 March 2014 using electronic databases and hand search. Randomized controlled trials published in English or German language, with a follow-up ≥6 months were included. From 231 titles identified, nine publications were eligible for inclusion.
  
  
  RESULTS
  Among the studies included, showing some risk of bias, seven reported on patients with chronic periodontitis and two with aggressive periodontitis. Minor adverse events were described in five studies. A synthesis of results using a vote counting method was applied. Significant (p < 0.05) beneficial effects of azithromycin were shown in six studies for probing depth changes and in five studies for clinical attachment level changes.
  
  
  CONCLUSIONS
  In contrast to aggressive periodontitis patients, data from this analysis indicate a potential benefit of systemic azithromycin as adjunctive to non-surgical periodontal therapy in chronic periodontitis patients.
  
  
  CONCLUSIONS
  When contraindications for the standard antibiotics are present, azithromycin (AZM) may be considered as alternative systemically administered antibiotic drug in selected cases of chronic periodontitis.
authors.affiliation: Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland.
authors.forename: Sabrina L
authors.initials: SL
authors.lastname: Buset
authors.affiliation: Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland.
authors.forename: Nicola U
authors.initials: NU
authors.lastname: Zitzmann
authors.affiliation: Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland.
authors.forename: Roland
authors.initials: R
authors.lastname: Weiger
authors.affiliation: Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, CH-4056, Basel, Switzerland. clemens.walter@unibas.ch.
authors.forename: Clemens
authors.initials: C
authors.lastname: Walter
mesh_terms: D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology; D016032:Randomized Controlled Trials as Topic
chemical_list: D017963:Azithromycin
keywords: Aggressive periodontitis; Azithromycin; Chronic periodontitis; Periodontal debridement