title: The free and cued selective reminding test for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: A prospective longitudinal study.
abstract: Amnestic mild cognitive impairment (aMCI) patients carry a greater risk of conversion to Alzheimer's disease (AD). Therefore, the International Working Group (IWG) on AD aims to consider some cases of aMCI as symptomatic prodromal AD. The core diagnostic marker of AD is a significant and progressive memory deficit, and the Free and Cued Selective Reminding Test (FCSRT) was recommended by the IWG to test memory in cases of possible prodromal AD. This study aims to investigate whether the performance on the FCSRT would enhance the ability to predict conversion to AD in an aMCI group. A longitudinal study was conducted on 88 aMCI patients, and neuropsychological tests were analysed on the relative risk of conversion to AD. During follow-up (23.82 months), 33% of the aMCI population converted to AD. An impaired FCSRT TR was significantly associated with the risk of conversion to dementia, with a mean time to conversion of 25 months. The FCSRT demonstrates utility for detecting AD at its prodromal stage, thus supporting its use as a valid clinical marker.
authors.affiliation: Faculty of Psychology and Educational Sciences, University of Coimbra, Portugal.|Visual Neuroscience Laboratory, Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Portugal.
authors.forename: Raquel
authors.identifier: 0000-0003-1221-915X
authors.initials: R
authors.lastname: Lemos
authors.affiliation: Psychology and Health Research Unit (UIPES), Department of Psychological Sciences, ISPA - Instituto Universitário, Lisboa, Portugal.
authors.forename: João
authors.initials: J
authors.lastname: Marôco
authors.affiliation: Faculty of Psychology and Educational Sciences, University of Coimbra, Portugal.
authors.forename: Mário R
authors.initials: MR
authors.lastname: Simões
authors.affiliation: Neurology Department of the Coimbra Hospital and University Center, Portugal.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Santiago
authors.affiliation: Neurology Department of the Coimbra Hospital and University Center, Portugal.
authors.forename: José
authors.initials: J
authors.lastname: Tomás
authors.affiliation: Neurology Department of the Coimbra Hospital and University Center, Portugal.|Faculty of Medicine, University of Coimbra, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Santana
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000209:etiology*; D001057:Apolipoproteins E / Q000235:genetics; D060825:Cognitive Dysfunction / Q000235:genetics / Q000503:physiopathology*; D003463:Cues; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D001057:Apolipoproteins E
keywords: Alzheimer's disease; free and cued selective reminding test; longitudinal; memory; mild cognitive impairment