title: Green synthesis of gold nanoparticles and their anticancer activity.
abstract: As the nano revolution unfolds, it is imperative to integrate nanoscience and medicine. The secret gleaned from nature have led to the generation of biogenic technologies for the fabrication of advanced nanomaterials. Present investigation discloses the gold nanoparticles biosynthesizing capability of the flower of pharmacologically important treeCouroupita guianensis. Rapid, cost-effective, one-step process of synthesis has been achieved. Newly genre gold nanoparticles were characterized by involving UV-vis spectroscopy, FTIR, XRD, SEM, and TEM analysis. Interestingly, as a result of extensive screening on the application of newly synthesized gold nanoparticles their anticancer potential has been discovered using MTT assay, DNA fragmentation, apoptosis by DAPI staining, and comet assay for DNA damage.
authors.affiliation: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore, 632 115 India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Geetha
authors.affiliation: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore, 632 115 India.
authors.forename: Thirunavukkarasu
authors.initials: T
authors.lastname: Ashokkumar
authors.affiliation: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore, 632 115 India.
authors.forename: Selvaraj
authors.initials: S
authors.lastname: Tamilselvan
authors.affiliation: Centre for Ocean Research, Sathyabama University, Chennai, 600 119 India.
authors.forename: Kasivelu
authors.initials: K
authors.lastname: Govindaraju
authors.affiliation: Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai, Tamilnadu India.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sadiq
authors.affiliation: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore, 632 115 India.
authors.forename: Ganesan
authors.initials: G
authors.lastname: Singaravelu
keywords: Anticancer; Couroupita guianensis; DNA fragmentation; Gold nanoparticles