title: Design of modified xanthan mini-matrices for monitoring oral discharge of highly soluble Soluplus®-glibenclamide dispersion.
abstract: In this work, Soluplus(®) was used as a hydrophilic carrier for the preparation of solid dispersion (SD) of a model BCS class II drug, glibenclamide by applying hot melting process and microwave irradiation in combination. Increasing the concentration of carrier relative to drug significantly increased the drug solubility, which corresponded to a maximum 75 fold increase at a drug:carrier ratio of 1:7. Scanning electron microscopy, differential scanning calorimetry, and x-ray diffraction analyses confirmed complete amorphization of the drug in SD. In animal study, about two fold reductions in hyperglycemic level were achieved by SD compared to pure drug. SD-loaded O-carboxymethyl xanthan mini-matrices controlled the release of drug into gastro-luminal fluid over longer duration. The drug release corroborated with pH-dependent swelling behavior of the matrices and approximated anomalous diffusion mechanism. This study proved the potential of Soluplus(®)-based dispersion in improving the clinical performance of the drug, especially when embedded in modified xanthan mini-matrices.
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
authors.forename: Paromita
authors.initials: P
authors.lastname: Bakshi
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
authors.forename: Sayantan
authors.initials: S
authors.lastname: Sadhukhan
authors.affiliation: Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India. Electronic address: sabya245@rediffmail.com.
authors.forename: Sabyasachi
authors.initials: S
authors.lastname: Maiti
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001786:Blood Glucose / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005905:Glyburide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011817:Rabbits; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001786:Blood Glucose; D004337:Drug Carriers; D007004:Hypoglycemic Agents; D011135:Polysaccharides, Bacterial; D011145:Polyvinyls; C572167:polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; D011092:Polyethylene Glycols; D005905:Glyburide; C002563:xanthan gum
keywords: Carboxymethyl xanthan gum; Controlled drug release; Hypoglycemic activity; Microwave-irradiation; Solid dispersion; Soluplus(®)