title: Divergent behavior of mucosal memory T cells.
abstract: Memory CD4 T cells are strategically positioned at mucosal surfaces to initiate a robust adaptive immune response. The detection of specific antigen via the T-cell receptor causes these memory T cells to unleash a potent antimicrobial response that includes rousing local innate immune populations for tissue-specific defense. Paradoxically, these same memory T cells can also be stimulated by nonantigen-specific signals that are generated by the activity of local innate immune cells. This versatility of mucosal memory T cells in both the initiation and the sensing of local innate immunity could be a vitally important asset during pathogen defense but alternatively could be responsible for initiating and maintaining chronic inflammation in sensitive mucosal tissues.
authors.affiliation: Department of Anatomy, Physiology, and Cell Biology, Center for Comparative Medicine, UC Davis, Davis, California, USA.
authors.forename: O H
authors.initials: OH
authors.lastname: Pham
authors.affiliation: Department of Anatomy, Physiology, and Cell Biology, Center for Comparative Medicine, UC Davis, Davis, California, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: McSorley
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009298:Nasal Polyps / Q000276:immunology*; D053724:Receptors, Interleukin-18 / Q000276:immunology*; D053219:Receptors, Tumor Necrosis Factor, Member 25 / Q000276:immunology*
chemical_list: D053724:Receptors, Interleukin-18; D053219:Receptors, Tumor Necrosis Factor, Member 25