title: Electronic polymers in lipid membranes.
abstract: Electrical interfaces between biological cells and man-made electrical devices exist in many forms, but it remains a challenge to bridge the different mechanical and chemical environments of electronic conductors (metals, semiconductors) and biosystems. Here we demonstrate soft electrical interfaces, by integrating the metallic polymer PEDOT-S into lipid membranes. By preparing complexes between alkyl-ammonium salts and PEDOT-S we were able to integrate PEDOT-S into both liposomes and in lipid bilayers on solid surfaces. This is a step towards efficient electronic conduction within lipid membranes. We also demonstrate that the PEDOT-S@alkyl-ammonium:lipid hybrid structures created in this work affect ion channels in the membrane of Xenopus oocytes, which shows the possibility to access and control cell membrane structures with conductive polyelectrolytes.
authors.affiliation: 1] Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden [2] Current address: National ESCA Surface Analysis Center for Biomedical Problems, Department of Bioengineering, University of Washington, Seattle, WA, US-98195, United States.
authors.forename: Patrik K
authors.initials: PK
authors.lastname: Johansson
authors.affiliation: 1] Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden [2] Current address: Systems and Synthetic Biology, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-41296, Gothenburg, Sweden.
authors.forename: David
authors.initials: D
authors.lastname: Jullesson
authors.affiliation: Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Elfwing
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, SE-58185, Linköping, Sweden.
authors.forename: Sara I
authors.initials: SI
authors.lastname: Liin
authors.affiliation: Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden.
authors.forename: Chiara
authors.initials: C
authors.lastname: Musumeci
authors.affiliation: Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden.
authors.forename: Erica
authors.initials: E
authors.lastname: Zeglio
authors.affiliation: Department of Clinical and Experimental Medicine, Linköping University, SE-58185, Linköping, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Elinder
authors.affiliation: Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden.
authors.forename: Niclas
authors.initials: N
authors.lastname: Solin
authors.affiliation: Biomolecular and Organic Electronics, Department of Physics Chemistry and Biology, Linköping University, SE-58183, Linköping, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Inganäs
mesh_terms: D004583:Electrons; D008051:Lipid Bilayers; D008055:Lipids / Q000737:chemistry*; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D011108:Polymers / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D008055:Lipids; D008567:Membranes, Artificial; D011108:Polymers