title: The effect of occlusion therapy on motion perception deficits in amblyopia.
abstract: There is growing evidence for deficits in motion perception in amblyopia, but these are rarely assessed clinically. In this prospective study we examined the effect of occlusion therapy on motion-defined form perception and multiple-object tracking. Participants included children (3-10years old) with unilateral anisometropic and/or strabismic amblyopia who were currently undergoing occlusion therapy and age-matched control children with normal vision. At the start of the study, deficits in motion-defined form perception were present in at least one eye in 69% of the children with amblyopia. These deficits were still present at the end of the study in 55% of the amblyopia group. For multiple-object tracking, deficits were present initially in 64% and finally in 55% of the children with amblyopia, even after completion of occlusion therapy. Many of these deficits persisted in spite of an improvement in amblyopic eye visual acuity in response to occlusion therapy. The prevalence of motion perception deficits in amblyopia as well as their resistance to occlusion therapy, support the need for new approaches to amblyopia treatment.
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of British Columbia, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. Electronic address: giaschi@mail.ubc.ca.
authors.forename: Deborah
authors.initials: D
authors.lastname: Giaschi
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of British Columbia, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. Electronic address: cmcchapman@gmail.com.
authors.forename: Christine
authors.initials: C
authors.lastname: Chapman
authors.affiliation: Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada. Electronic address: kmeier@psych.ubc.ca.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Meier
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of British Columbia, 4480 Oak Street, Vancouver, BC V6H 3V4, Canada. Electronic address: sathyasrinarasimhan16@neco.edu.
authors.forename: Sathyasri
authors.initials: S
authors.lastname: Narasimhan
authors.affiliation: Department of Psychology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, Canada. Electronic address: dregan@yorku.ca.
authors.forename: David
authors.initials: D
authors.lastname: Regan
mesh_terms: D000293:Adolescent; D000550:Amblyopia / Q000503:physiopathology / Q000628:therapy*; D000704:Analysis of Variance; D015858:Anisometropia / Q000503:physiopathology; D001458:Bandages; D002648:Child; D005260:Female; D005556:Form Perception; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D011446:Prospective Studies; D012683:Sensory Deprivation / Q000502:physiology*; D013285:Strabismus / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology
keywords: Amblyopia; Motion perception; Motion-defined form; Multiple-object tracking; Occlusion therapy; Visual development