title: Copper-catalyzed ligand-free amidation of aryl iodides and amino acid amides to synthesize C3-(Z)-1H-benzo[e][1,4]diazepin-2(3H)-ones.
abstract: An effective synthetic method for C3-chiral 1,4-benzodiazepine-2-ones is described in this paper, reporting good yields and high enantioselectivity with a novel approach to an ipso-halo displacement-cyclization benzodiazepine route.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Road, Xuanwu District, Beijing, 100050, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Hu
authors.affiliation: Tsinghua-Peking Center for Life Sciences, Beijing, People's Republic of China.|Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian District, Beijing, 100084, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Road, Xuanwu District, Beijing, 100050, People's Republic of China. gangliu27@tsinghua.edu.cn.|Tsinghua-Peking Center for Life Sciences, Beijing, People's Republic of China. gangliu27@tsinghua.edu.cn.|Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Haidian District, Beijing, 100084, People's Republic of China. gangliu27@tsinghua.edu.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000577:Amides; D000596:Amino Acids; D007454:Iodides; D001569:Benzodiazepines; D003300:Copper
keywords: Amidation; C3-(Z)-1H-benzo[e][1, 4]diazepin-2(3H)-ones; Copper-catalyzed; Cyclization; Diazepinones