title: Viral Agents of Diarrhea in Young Children in Two Primary Health Centers in Edo State, Nigeria.
abstract: Enteric viruses have been shown to be responsible for diarrhea among children during their early childhood. This study was carried out to determine the prevalence of rotavirus, adenovirus, and norovirus infection in young children with diarrhea in two primary health centers in Edo State, Nigeria. A total of 223 stool specimens were collected from children aged 0-36 months with clinical signs of diarrhea and 59 apparently healthy age-matched children as control. These specimens were investigated for three viral agents using immunochromatographic technique (ICT). The overall results showed that at least one viral agent was detected in 95/223 (42.6%) of the children with diarrhea while the control had none. The prevalence of rotavirus was 28.3%, adenovirus 19.3%, and norovirus 3.6%. There was a significant association between age group and infection (P < 0.0001). Seasonal pattern of enteric viruses was not statistically significant (P = 0.17). The overall coinfection rate was 7.6% and rotavirus-adenovirus coinfection had the highest with 5.4%. Rotavirus was the most prevalent viral agent. Coinfections are not uncommon among the population studied. The most commonly associated clinical symptom of viral diarrhea in this study was vomiting. Viral diagnostic tests are advocated for primary health care facilities in this locality.
authors.affiliation: Department of Medical Microbiology, University of Benin Teaching Hospital, PMB 1111, Benin City 300283, Nigeria.
authors.forename: Paul Erhunmwunse
authors.initials: PE
authors.lastname: Imade
authors.affiliation: Department of Microbiology, Faculty of Life Sciences, University of Benin, PMB 1154, Benin City 300283, Nigeria.
authors.forename: Nosakhare Odeh
authors.initials: NO
authors.lastname: Eghafona