title: [Diagnostic value of neuronal auto-antibodies and neurodegeneration of central conduction tracts in exposure to metallic mercury vapors].
abstract: Stationary medical examination covered chemical production workers (47 individuals) with long length of service, exposed to metallic mercury vapors, and patients in remote stage of chronic mercury intoxication (51 individuals). The examination included registration of somatosensory evoked potentials and levels of neuronal antibodies. Analysis of results helped to reveal relationship between intensity of structural disorders involving central afferent conduction tracts and changes in levels of auto-antibodies to S-100 proteins, general myelin protein, myelin-associated glycoprotein--that can indicate general neurodegeneration process in central structures. Level of neuronal antibodies can serve as a unique marker of demyelination intensity of central conduction tracts under exposure to neurotoxic chemicals and considerably decrease cost of examination during regular medical checkup.
authors.forename: D V
authors.initials: DV
authors.lastname: Rusanova
authors.forename: G M
authors.initials: GM
authors.lastname: Bodienkova
authors.forename: O L
authors.initials: OL
authors.lastname: Lakhman
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001323:Autoantibodies; D006801:Humans; D008297:Male; D020262:Mercury Poisoning, Nervous System / Q000175:diagnosis*; D009434:Neural Pathways / Q000473:pathology*; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis*; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D000395:Air Pollutants, Occupational; D001323:Autoantibodies