title: Antimicrobial Resistance Profile and Genotypic Characteristics of Streptococcus suis Capsular Type 2 Isolated from Clinical Carrier Sows and Diseased Pigs in China.
abstract: Streptococcus suis serotype 2 is an important zoonotic pathogen. Antimicrobial resistance phenotypes and genotypic characterizations of S. suis 2 from carrier sows and diseased pigs remain largely unknown. In this study, 96 swine S. suis type 2, 62 from healthy sows and 34 from diseased pigs, were analyzed. High frequency of tetracycline resistance was observed, followed by sulfonamides. The lowest resistance of S. suis 2 for β-lactams supports their use as the primary antibiotics to treat the infection of serotype 2. In contrast, 35 of 37 S. suis 2 with MLSB phenotypes were isolated from healthy sows, mostly encoded by the ermB and/or the mefA genes. Significantly lower frequency of mrp+/epf+/sly+ was observed among serotype 2 from healthy sows compared to those from diseased pigs. Furthermore, isolates from diseased pigs showed more homogeneously genetic patterns, with most of them clustered in pulsotypes A and E. The data indicate the genetic complexity of S. suis 2 between herds and a close linkage among isolates from healthy sows and diseased pigs. Moreover, many factors, such as extensive use of tetracycline or diffusion of Tn916 with tetM, might have favored for the pathogenicity and widespread dissemination of S. suis serotype 2.
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Chunping
authors.initials: C
authors.lastname: Zhang
authors.affiliation: China Animal Disease Control Center, Beijing 100125, China.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Xuezheng
authors.initials: X
authors.lastname: Fan
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wen
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Shixin
authors.initials: S
authors.lastname: Xu
authors.affiliation: National Antimicrobial Resistance Monitoring Laboratory in Bacteria of Animal Origin, Department of Inspection Technology Research, China Institute of Veterinary Drug Control, Beijing 100081, China.
authors.forename: Yibao
authors.initials: Y
authors.lastname: Ning
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002681:China; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005838:Genotype; D013290:Streptococcal Infections / Q000188:drug therapy / Q000235:genetics* / Q000662:veterinary; D017011:Streptococcus suis / Q000187:drug effects / Q000235:genetics*; D013552:Swine
chemical_list: D000900:Anti-Bacterial Agents