title: Rituximab-associated interstitial lung disease in fibrillary glomerulonephritis.
abstract: Rituximab (RTX) is a chimeric monoclonal antibody against CD20+ B cells increasingly used to treat kidney disorders. RTX-induced pulmonary disease has been reported in patients treated for haematological disorders, and a few cases have been observed in patients with underlying rheumatological conditions. We report a case of non-infectious interstitial pneumonitis associated with RTX use in a 49-year-old patient with primary (fibrillary) glomerulonephritis. As typically observed, discontinuation of the drug and prompt initiation of glucocorticoids led to resolution of pulmonary manifestations. However, fatalities have been reported and nephrologists treating glomerulonephritis patients with RTX should be aware of the existence of this potentially lethal complication.
authors.affiliation: Nephrology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain ; REDINREN.
authors.forename: Valeria
authors.initials: V
authors.lastname: Sainz-Prestel
authors.affiliation: Nephrology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain ; REDINREN.
authors.forename: Jesus
authors.initials: J
authors.lastname: Hernandez-Perez
authors.affiliation: Nephrology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain ; REDINREN.
authors.forename: Jorge
authors.initials: J
authors.lastname: Rojas-Rivera
authors.affiliation: Pathology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain ; ICU , IIS-Fundación Jimenez Diaz/UAM , Madrid , Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Milicua-Muñoz
authors.affiliation: Nephrology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Egido
authors.affiliation: Nephrology , IIS-Fundación Jimenez Diaz/UAM/IRSIN , Madrid , Spain ; REDINREN.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
keywords: adverse effects; biological; glomerulonephritis; lung