title: Android fat distribution affects some hemostatic parameters in women with polycystic ovary syndrome compared with healthy control subjects matched for age and body mass index.
abstract: OBJECTIVE
  To correlate hemostatic parameters with clinical markers of fat distribution and laboratory variables in women with polycystic ovary syndrome (PCOS) compared with healthy control subjects.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary teaching hospital.
  
  
  METHODS
  Forty-five women with PCOS and 45 control women matched for age and body mass index (BMI).
  
  
  METHODS
  Clinical evaluation and venipuncture.
  
  
  METHODS
  Age, BMI, waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), Ferriman-Gallwey index, fasting glucose, fasting insulin, total testosterone, free testosterone (FT), thrombin-activatable fibrinolysis inhibitor (TAFI), D-dimer, plasminogen activator inhibitor (PAI) 1, and the parameters of thrombin generation test (TGT), including the lag time (Tlag), time to peak thrombin generation (Tmax), peak concentration (Cmax), and the area under the thrombin generation curve (TAUC).
  
  
  RESULTS
  In the PCOS group, BMI and WC correlated positively with TAFI, D-dimer, PAI-1, Cmax, and TAUC; HC with D-dimer and PAI-1; WHR with TAFI, D-dimer, and PAI-1; glucose with TAFI; insulin and homeostasis-model assessment of insulin resistance with PAI-1; and FT with Cmax and TAUC. Age correlated positively with D-dimer and PAI-1, and negatively with Tlag and Tmax. In the control group, there were no correlations between clinical markers of fat distribution and hemostatic parameters, but age and fasting glucose correlated positively with PAI-1, and FT with Tmax and TAUC.
  
  
  CONCLUSIONS
  In PCOS, android body fat distribution may directly affect hemostatic parameters, particularly in young and overweight women. Further studies are needed to establish a correlation between these results and an increase in thromboembolic risk.
authors.affiliation: Department of Gynecology and Obstetrics, School of Medical Sciences, University of Campinas, São Paulo, Brazil.
authors.forename: Maria Raquel Marques Furtado
authors.initials: MR
authors.lastname: de Mendonça-Louzeiro
authors.affiliation: Department of Internal Medicine, Hemostasis Laboratory, Blood Center, University of Campinas, São Paulo, Brazil.
authors.forename: Joyce Maria
authors.initials: JM
authors.lastname: Annichino-Bizzacchi
authors.affiliation: Department of Gynecology and Obstetrics, School of Medical Sciences, University of Campinas, São Paulo, Brazil. Electronic address: laguna.unicamp@gmail.com.
authors.forename: Cristina Laguna
authors.initials: CL
authors.lastname: Benetti-Pinto
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001823:Body Composition / Q000502:physiology; D001824:Body Constitution / Q000502:physiology; D050218:Body Fat Distribution / Q000379:methods*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D056128:Obesity, Abdominal / Q000453:epidemiology / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology / Q000378:metabolism*; D049629:Waist-Hip Ratio / Q000379:methods; D055815:Young Adult
keywords: Polycystic ovary syndrome; body fat distribution; fibrinolysis; hemostatic parameters; venous thrombosis