title: Serum paraoxonase and arylesterase values as antioxidants in healthy premature infants at fasting and posprandial times.
abstract: OBJECTIVE
  Newborn infants, particularly preterm infants, are at greater risk of oxidative stress because of an imbalance between high oxidant loads and immature antioxidant defenses. In several studies, the activities of serum paraoxonase (PON) and arylesterase (ARE) have been found to decline in patients under increased oxidative stress. We investigated the relationships between PON-1 and ARE with fasting and postprandial in premature newborns in this study.
  
  
  METHODS
  Serum paraoxonase-1 and arylesterase levels were investigated in premature infants less than 37 weeks, after birth while they were fasting and postprandial.
  
  
  RESULTS
  The paraoxonase-1 and arylesterase values of infants in fasting were significantly lower than the values in postprandial (for paraoxonase-1, p = 0.034, 0.002, and 0.002, respectively; for arylesterase, p < 0.001, 0.002, and p < 0.001, respectively).
  
  
  CONCLUSIONS
  In premature infants, paraoxonase-1 and arylesterase values are increased in postprandial and reduced in fasting, showing that these neonates are subjected to oxidative stress. Thus, starting feeding as soon as possible in premature newborns is vital to protect them from oxidative damage.
authors.affiliation: Department of Neonatal Intensive Care Unit, Erzurum District Training and Research Hospital, Erzurum, Turkey. omerkilic7@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Kahveci
authors.forename: F
authors.initials: F
authors.lastname: Laloglu
authors.forename: O
authors.initials: O
authors.lastname: Kilic
authors.forename: M
authors.initials: M
authors.lastname: Ciftel
authors.forename: A
authors.initials: A
authors.lastname: Yildirim
authors.forename: Z
authors.initials: Z
authors.lastname: Orbak
authors.forename: V
authors.initials: V
authors.lastname: Ertekin
authors.forename: E
authors.initials: E
authors.lastname: Laloglu
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human