title: Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study.
abstract: OBJECTIVE
  To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics.
  
  
  METHODS
  The study entailed histopathological diagnoses carried out on paraffin blocks at the Department of Pathology of the Medical Hospital of Duzce University, Turkey, between 2005 and 2011. Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95was performed on tissue microarray using standard procedures. Each patient's age and gender as well as the tumour's grade, stage, diameter, ureteral surgical margins, vascular invasion, capsule invasion and subtype were assessed. In order to determine if the cases were still alive, relatives were telephoned and identity registration records were checked. SPSS 18 was used for statistical analysis.
  
  
  RESULTS
  There were 49 paraffin blocks in the study.Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026). There was a significant correlation between cluster of differentiation 95and the Fuhrman grade (p=0.050).
  
  
  CONCLUSIONS
  Expression of cluster of differentiation 95and cyclooxygenase-2 may be correlated with prognostic parameters in renal cell carcinoma and may also be associated with tumour progression.
authors.affiliation: Department of Pathology, Medical Faculty of Duzce University, Duzce, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
authors.affiliation: Department of Urology, Samsun Region Education and Research Hospital, Samsun, Turkey.
authors.forename: Hasan Riza
authors.initials: HR
authors.lastname: Aydin
authors.affiliation: Department of Biophysics, Medical Faculty, Duzce, Turkey.
authors.forename: Anzel
authors.initials: A
authors.lastname: Bahadir
authors.affiliation: Department of Pathology, Ataturk University of Medical Faculty, Erzurum, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Gündogdu
authors.affiliation: Department of Pathology, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Balta
authors.affiliation: Department of Pathology, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Sener
authors.affiliation: Department of Urology, Medical Faculty of Duzce University, Duzce, Turkey.
authors.forename: Muhammet Ali
authors.initials: MA
authors.lastname: Kayikci
authors.affiliation: Pathology Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Albayrak
authors.affiliation: Department of Pathology, Erzurum Region Education and Research Hospital, Erzurum, Turkey.
authors.forename: Fazli
authors.initials: F
authors.lastname: Erdogan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D046888:Tissue Array Analysis; D047368:Tumor Burden; D019014:fas Receptor / Q000378:metabolism*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: CD95, Cyclooxygenase-2, COX-2,  Prognosis, Renal cell carcinomas.