title: From Semantic to Social Deficits: Dysfunction of the Nondominant Posterior Perisylvian Area in Schizophrenia.
abstract: Schizophrenia is characterized by profound deficits in social competence and functioning, independent from active psychotic symptoms at different stages of the disease. Social deficits in schizophrenia are clinically well characterized, but their neurobiological underpinnings are undetermined. This article reviews recent evidence supporting heritable deficits in a circuit necessary for appropriate naming of emotions and mental states in others, centered at the temporoparietal junction of the nondominant hemisphere. The clinical implications of this model are discussed, including the potential use of rehabilitation techniques oriented to recognition and naming of emotions and mental states as a necessary step for social rehabilitation.
authors.affiliation: From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN).
authors.forename: Salvador M
authors.initials: SM
authors.lastname: Guinjoan
authors.affiliation: From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN).
authors.forename: Delfina
authors.initials: D
authors.lastname: de Achával
authors.affiliation: From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN).
authors.forename: Mirta F
authors.initials: MF
authors.lastname: Villarreal
authors.affiliation: From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN).
authors.forename: Valeria
authors.initials: V
authors.lastname: Abusamra
authors.affiliation: From the Dept. of Neurology & Psychiatry, Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI) Teaching Unit, FLENI Instituto de Investigaciones "Raúl Carrea," School of Medicine (SMG, DdA, MFV), and Consejo Nacional de Investigaciones Científicas y Técnicas, Cátedra de Psicolingüística, Facultad de Filosofía y Letras (VA), University of Buenos Aires, Buenos Aires, Argentina; and the Dept. of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, University of Miami, Miami, FL (CBN).
authors.forename: Charles B
authors.initials: CB
authors.lastname: Nemeroff
mesh_terms: D002540:Cerebral Cortex / Q000503:physiopathology*; D004644:Emotions; D005149:Facial Expression; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D012938:Social Perception