title: Switchable Release of Entrapped Nanoparticles from Alginate Hydrogels.
abstract: Natural biological processes are intricately controlled by the timing and spatial distribution of various cues. To mimic this precise level of control, the physical sizes of gold nanoparticles are utilized to sterically entrap them in hydrogel materials, where they are subsequently released only in response to ultrasound. These nanoparticles can transport bioactive factors to cells and direct cell behavior on-demand.
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Cathal J
authors.initials: CJ
authors.lastname: Kearney
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Hadas
authors.initials: H
authors.lastname: Skaat
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Kennedy
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hu
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Max
authors.initials: M
authors.lastname: Darnell
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Raimondo
authors.affiliation: Harvard University School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, 40 Oxford St., Cambridge, MA 02138, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Mooney
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D013010:Sonication
chemical_list: D000464:Alginates; D055396:Bone Morphogenetic Protein 2; D004337:Drug Carriers; D006603:Hexuronic Acids; D020100:Hydrogels; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D006046:Gold; D020723:Glucuronic Acid
keywords: gold nanoparticles; on-demand release; self-healing alginate; ultrasound