title: Physiologic imaging in acute stroke: Patient selection.
abstract: Treatment of acute stroke is changing, as endovascular intervention becomes an important adjunct to tissue plasminogen activator. An increasing number of sophisticated physiologic imaging techniques have unique advantages and applications in the evaluation, diagnosis, and treatment-decision making of acute ischemic stroke. In this review, we first highlight the strengths, weaknesses, and possible indications for various stroke imaging techniques. How acute imaging findings in each modality have been used to predict functional outcome is discussed. Furthermore, there is an increasing emphasis on using these state-of-the-art imaging modalities to offer maximal patient benefit through IV therapy, endovascular thrombolytics, and clot retrieval. We review the burgeoning literature in the determination of stroke treatment based on acute, physiologic imaging findings.
authors.affiliation: Department of Neurological Surgery, Vanderbilt University School of Medicine, USA.
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Morgan
authors.affiliation: Meharry Medical College School of Medicine, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Stephens
authors.affiliation: Department of Neurological Surgery, Vanderbilt University School of Medicine, USA.
authors.forename: Scott L
authors.initials: SL
authors.lastname: Zuckerman
authors.affiliation: Vanderbilt University School of Medicine, USA.
authors.forename: Magarya S
authors.initials: MS
authors.lastname: Waitara
authors.affiliation: Department of Neurological Surgery, Vanderbilt University School of Medicine, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Morone
authors.affiliation: Department of Neurological Surgery, Vanderbilt University School of Medicine, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Dewan
authors.affiliation: Department of Neurosurgery, Icahn School of Medicine at Mouth Sinai, USA j.mocco@mountsinai.org.
authors.forename: J
authors.initials: J
authors.lastname: Mocco
mesh_terms: D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D018579:Patient Selection; D020521:Stroke / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
keywords: Stroke; angiography; multimodal imaging; patient selection; prospective studies; thrombolytic therapy