title: Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats.
abstract: Organotins (OTs) are environmental contaminants used as biocides in antifouling paints that have been shown to be endocrine disrupters. However, studies evaluating the effects of OTs accumulated in seafood (LNI) on reproductive health are particularly sparse. This study demonstrates that LNI leads to impairment in the reproductive tract of female rats, as the estrous cycle development, as well as for ovary and uterus morphology. Rats were treated with LNI, and their reproductive morphophysiology was assessed. Morphophysiological abnormalities, such as irregular estrous cycles, abnormal ovarian follicular development and ovarian collagen deposition, were observed in LNI rats. An increase in luminal epithelia and ERα expression was observed in the LNI uteri. Together, these data provide in vivo evidence that LNI are toxic for reproductive morphophysiology, which may be associated with risks to reproductive function.
authors.affiliation: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors.forename: Priscila L
authors.initials: PL
authors.lastname: Podratz
authors.affiliation: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Merlo
authors.affiliation: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Sena
authors.affiliation: Department of Biological Sciences, Federal University of Espírito Santo, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Morozesk
authors.affiliation: Department of Biological Sciences, Federal University of Espírito Santo, Brazil.
authors.forename: Marina M
authors.initials: MM
authors.lastname: Bonomo
authors.affiliation: Department of Biological Sciences, Federal University of Espírito Santo, Brazil.
authors.forename: Silvia T
authors.initials: ST
authors.lastname: Matsumoto
authors.affiliation: Department of Biological Sciences, Federal University of Espírito Santo, Brazil.
authors.forename: Mércia B
authors.initials: MB
authors.lastname: da Costa
authors.affiliation: Department of Biological Sciences, Federal University of Espírito Santo, Brazil.
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Zamprogno
authors.affiliation: Department of Chemistry, Federal University of Espírito Santo, Brazil.
authors.forename: Poliane A A
authors.initials: PA
authors.lastname: Brandão
authors.affiliation: Department of Chemistry, Federal University of Espírito Santo, Brazil.
authors.forename: Maria T W D
authors.initials: MT
authors.lastname: Carneiro
authors.affiliation: Department of Biochemistry and Molecular Biology, Federal University of Ceara, Brazil.
authors.forename: Emilio de C
authors.initials: Ede C
authors.lastname: Miguel
authors.affiliation: Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Miranda-Alves
authors.affiliation: Department of Morphology, Federal University of Espírito Santo, Brazil.
authors.forename: Ian V
authors.initials: IV
authors.lastname: Silva
authors.affiliation: Department of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: jbgraceli@gmail.com.
authors.forename: Jones B
authors.initials: JB
authors.lastname: Graceli
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D052244:Endocrine Disruptors / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005506:Food Contamination; D049851:Gastropoda; D009947:Organotin Compounds / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D017208:Rats, Wistar; D017747:Seafood / Q000009:adverse effects*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014874:Water Pollutants, Chemical / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D009947:Organotin Compounds; D014874:Water Pollutants, Chemical; D003094:Collagen
keywords: Endocrine disruption; Environmental contamination; Organotins accumulated in seafood; Reproductive toxicity