title: Pediatric Lichen Planopilaris: Clinicopathologic Study of Four New Cases and a Review of the Literature.
abstract: Lichen planopilaris (LPP) is a rare form of cicatricial alopecia that has occasionally been reported in children. Because of the limited number of patients reported, little information is available about demographic characteristics, clinical presentation, or treatment options for these patients. A retrospective chart review of LPP cases in patients under 18 years of age from 1976 to 2013 was performed to further define clinicopathologic features of pediatric LPP. Four pediatric LPP patients ages 13 to 16 years were identified (three male, one female). One patient had scalp pruritus and one had other cutaneous findings of lichen planus (LP). Perifollicular scale and scarring were the most common physical examination findings, although changes mimicking those of alopecia areata were observed. Three patients were treated with topical or intralesional steroids. One patient was treated with minocycline. Histopathologic findings included perifollicular interface and perifollicular fibrosis in all cases. There was focal interfollicular interface in two cases and mild dermal mucin in one case. LPP is exceedingly rare in children. It may be misdiagnosed as alopecia areata in children because of the lack of symptoms and other features of LP. There should be a high index of suspicion for LPP in children with alopecia that is unresponsive to standard treatment or who have findings that are atypical for more common childhood alopecias.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Christensen
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lehman
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota.|Department of Pediatrics, Mayo Clinic, Rochester, Minnesota.
authors.forename: Megha M
authors.initials: MM
authors.lastname: Tollefson
mesh_terms: D000293:Adolescent; D000506:Alopecia Areata / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D001707:Biopsy, Needle; D002990:Clobetasol / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008010:Lichen Planus / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008911:Minocycline / Q000008:administration & dosage; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D014221:Triamcinolone; D002990:Clobetasol; D008911:Minocycline