title: Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh.
abstract: Vibrio cholerae, the cause of cholera, induces both innate and adaptive immune responses in infected humans. Leptin is a hormone that plays a role in both metabolism and mediating immune responses. We characterized leptin levels in 11 children with cholera in Bangladesh, assessing leptin levels on days 2, 7, 30, and 180 following cholera. We found that patients at the acute stage of cholera had significantly lower plasma leptin levels than matched controls, and compared with levels in late convalescence. We then assessed immune responses to V. cholerae antigens in 74 children with cholera, correlating these responses to plasma leptin levels on day 2 of illness. In multivariate analysis, we found an association between day 2 leptin levels and development of later anti-cholera toxin B subunit (CtxB) responses. This finding appeared to be limited to children with better nutritional status. Interestingly, we found no association between leptin levels and antibody responses to V. cholerae lipopolysaccharide, a T cell-independent antigen. Our results suggest that leptin levels may be associated with cholera, including the development of immune responses to T cell-dependent antigens.
authors.forename: Brie
authors.initials: B
authors.lastname: Falkard
authors.forename: Taher
authors.initials: T
authors.lastname: Uddin
authors.forename: M Arifur
authors.initials: MA
authors.lastname: Rahman
authors.forename: Molly F
authors.initials: MF
authors.lastname: Franke
authors.forename: Amena
authors.initials: A
authors.lastname: Aktar
authors.forename: Muhammad Ikhtear
authors.initials: MI
authors.lastname: Uddin
authors.forename: Taufiqur Rahman
authors.initials: TR
authors.lastname: Bhuiyan
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Leung
authors.forename: Richelle C
authors.initials: RC
authors.lastname: Charles
authors.forename: Regina C
authors.initials: RC
authors.lastname: Larocque
authors.forename: Jason B
authors.initials: JB
authors.lastname: Harris
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Calderwood
authors.forename: Firdausi
authors.initials: F
authors.lastname: Qadri
authors.forename: Edward T
authors.initials: ET
authors.lastname: Ryan
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D001459:Bangladesh; D002675:Child, Preschool; D002771:Cholera / Q000097:blood*; D002772:Cholera Toxin / Q000276:immunology; D006760:Hospitalization; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D020738:Leptin / Q000097:blood*; D008070:Lipopolysaccharides / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D041241:Vibrio cholerae O1 / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D020738:Leptin; D008070:Lipopolysaccharides; D002772:Cholera Toxin