title: Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT.
abstract: This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good (1)O2 yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.
authors.affiliation: Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine, UMR 7274, 1 rue Grandville BP 20451, Nancy Cedex, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Stallivieri
authors.forename: Florent
authors.initials: F
authors.lastname: Le Guern
authors.forename: Régis
authors.initials: R
authors.lastname: Vanderesse
authors.forename: Esme
authors.initials: E
authors.lastname: Meledje
authors.forename: Giulio
authors.initials: G
authors.lastname: Jori
authors.forename: Céline
authors.initials: C
authors.lastname: Frochot
authors.forename: Samir
authors.initials: S
authors.lastname: Acherar
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology; D009033:Culicidae / Q000187:drug effects* / Q000528:radiation effects*; D007814:Larva / Q000187:drug effects / Q000528:radiation effects; D008288:Malaria / Q000517:prevention & control*; D015394:Molecular Structure; D009032:Mosquito Control / Q000379:methods; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013472:Sunlight
chemical_list: D000962:Antimalarials; D011166:Porphyrins; D011726:Pyridinium Compounds; C572418:meso-tri(N-methyl-pyridyl)mono(N-dodecyl-pyridyl)porphine