title: Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis.
abstract: BACKGROUND
  Neutrophil CD64 (nCD64) expression appears to be a promising marker of bacterial infections. The aim of this meta-analysis was to assess the accuracy of nCD64 expression for the diagnosis of sepsis in critically ill adult patients.
  
  
  METHODS
  We systematically searched PubMed, Embase, ISI Web of Knowledge, and the Cochrane Library for literature published between database inception and 19 May 2014, as well as reference lists of identified primary studies. Studies were included if they included assessment of the accuracy of nCD64 expression for sepsis diagnosis in adult patients and provided sufficient information to construct a 2×2 contingency table.
  
  
  RESULTS
  A total of 8 studies comprising 1986 patients fulfilled the inclusion criteria for the final analysis. The pooled sensitivity and specificity were 0.76 (95 % confidence interval [CI], 0.73-0.78) and 0.85 (95 % CI, 0.82-0.87), respectively. The positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 8.15 (95 % CI, 3.82-17.36), 0.16 (95 % CI, 0.09-0.30), and 60.41 (95 % CI, 15.87-229.90), respectively. The area under the summary receiver operating characteristic curve of nCD64 expression with Q* value were 0.95 (Q* =0.89).
  
  
  CONCLUSIONS
  On the basis of our meta-analysis, nCD64 expression is a helpful marker for early diagnosis of sepsis in critically ill patients. The results of the test should not be used alone to diagnose sepsis, but instead should be interpreted in combination with medical history, physical examination, and other test results.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Changjiang Road 10, Yuzhong District, Chongqing, China. kingb@tmmu.edu.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. lizhongyunde@126.com.
authors.forename: Zhong-Yun
authors.initials: ZY
authors.lastname: Li
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Changjiang Road 10, Yuzhong District, Chongqing, China. zengling_1025@126.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Zeng
authors.affiliation: The 153 Central Hospital of PLA Jinan Military Region, Zhengzhou, Henan Province, China. zhanganqiang@126.com.
authors.forename: An-Qiang
authors.initials: AQ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Changjiang Road 10, Yuzhong District, Chongqing, China. qiangwei2@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Changjiang Road 10, Yuzhong District, Chongqing, China. clgwjm@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Changjiang Road 10, Yuzhong District, Chongqing, China. hellojjx@126.com.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Jiang
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016638:Critical Illness / Q000453:epidemiology; D005786:Gene Expression Regulation; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*; D017452:Receptors, IgG / Q000096:biosynthesis* / Q000097:blood*; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG