title: Neonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy.
abstract: Neonatal seizures are associated with morbidity and mortality. Hypoxic-ischemic encephalopathy (HIE) is the most common cause of seizures in newborns. Neonatal animal models suggest that therapeutic hypothermia can reduce seizures and epileptiform activity in the setting of hypoxia-ischemia, however data from human studies have conflicting results. In this research highlight, we will discuss the findings of our recent study that demonstrated a decreased seizure burden in term newborns with moderate HIE treated with hypothermia.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA ; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Dawn
authors.initials: D
authors.lastname: Gano
authors.affiliation: School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Orbach
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Sonia L
authors.initials: SL
authors.lastname: Bonifacio
authors.affiliation: Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA ; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Glass
keywords: hypoxic-ischemic encephalopathy; newborn; seizure; therapeutic hypothermia