title: Durability of highly cross-linked polyethylene in total hip and total knee arthroplasty.
abstract: This article reviews the history of the development of highly cross-linked polyethylene and provides an in-depth review of the clinical results regarding the durability of highly cross-linked polyethylene (HXLPE) used in total hip arthroplasty (THA) and total knee arthroplasty (TKA). The use of polyethylene as a bearing surface has contributed to the success of THA and TKA; however, polyethylene wear and osteolysis can lead to failure. Ongoing clinical and retrieval studies are required to analyze outcomes at longer-term follow-up.
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, Suite 3700, Boston, MA 02114, USA. Electronic address: NDion1@Partners.org.
authors.forename: Neil T
authors.initials: NT
authors.lastname: Dion
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, Suite 3700, Boston, MA 02114, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Bragdon
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, Suite 3700, Boston, MA 02114, USA.
authors.forename: Orhun
authors.initials: O
authors.lastname: Muratoglu
authors.affiliation: Department of Orthopaedic Surgery, Massachusetts General Hospital, 55 Fruit Street, Suite 3700, Boston, MA 02114, USA.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Freiberg
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000379:methods*; D019245:Compressive Strength; D003432:Cross-Linking Reagents; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D020959:Polyethylene; D011474:Prosthesis Design / Q000379:methods*; D011475:Prosthesis Failure; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D003432:Cross-Linking Reagents; D014810:Vitamin E; D020959:Polyethylene
keywords: Highly cross-linked polyethylene; Osteolysis; Total hip arthroplasty; Total knee arthroplasty; Vitamin E