title: The knowledge system underpinning healthcare is not fit for purpose and must change.
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK ian.roberts@lshtm.ac.uk.
authors.forename: Ian
authors.initials: I
authors.lastname: Roberts
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Katharine
authors.initials: K
authors.lastname: Ker
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Phil
authors.initials: P
authors.lastname: Edwards
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Deirdre
authors.initials: D
authors.lastname: Beecher
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Daniela
authors.initials: D
authors.lastname: Manno
authors.affiliation: Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Sydenham
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D003625:Data Collection / Q000592:standards; D003695:Delivery of Health Care; D006801:Humans; D008490:Medical Informatics / Q000592:standards; D011642:Publications / Q000592:standards / Q000706:statistics & numerical data; D012196:Review Literature as Topic; D018401:Sample Size