title: Report of Allergic Reaction After Application of Botulinum Toxin.
abstract: Botulinum toxin is a widely used treatment with satisfactory results, and it is relatively safe in the doses used for cosmetic procedures. The authors report a case of allergic reaction to Chinese botulinum toxin serotype A (CBTX-A). Although this is a rare adverse event, it is nonetheless clinically relevant to healthcare professionals. A 44-year-old woman presented to the authors' hospital complaining of dynamic wrinkles. CBTX-A was used to treat her. Minutes after application, she developed urticarial plaques proximal to the injection site. The patient had an allergic reaction, as documented by a positive skin test, which was controlled by the administration of antihistamines and systemic corticosteroids. This report is intended to guide healthcare professionals faced with this type of adverse event regarding how to proceed without hindering the delivery and effectiveness of the treatment. When performed by a qualified health professional, this treatment brings excellent results in the vast majority of cases.
  
  
  METHODS
  5 Risk.
authors.affiliation: Department of Dermatology, University of São Paulo, São Paulo, Brazil.
authors.forename: Mariana Figueiroa
authors.initials: MF
authors.lastname: Careta
authors.affiliation: Department of Dermatology, University of São Paulo, São Paulo, Brazil.
authors.forename: Livia
authors.initials: L
authors.lastname: Delgado
authors.affiliation: Department of Dermatology, University of São Paulo, São Paulo, Brazil.
authors.forename: Régia
authors.initials: R
authors.lastname: Patriota
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects*; D003357:Cosmetic Techniques / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage; D006801:Humans; D007273:Injections, Intramuscular; D007428:Intradermal Tests; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D012074:Remission Induction; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome; D014581:Urticaria / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D006633:Histamine Antagonists; D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A