title: Orbital IgG4-Related Disease Detected by 11C-Methionine PET/CT.
abstract: A 64-year-old man presented with a complaint of left exophthalmos. Whole-body F-FDG PET/CT showed increased uptake in the soft tissue masses in the orbits, peripancreas, and left renal hilum. C-methionine (MET) PET/CT of the head and neck showed increased uptake in the orbits, and the SUVmax of the left orbital lesion was 7.0. The patient was finally diagnosed as IgG4-related disease by the results of increased serum IgG4 and the biopsy of the orbital lesion. Although C-MET is generally considered as a tumor-specific tracer, fibrous tissues of IgG4-related disease may be visualized by C-MET PET/CT.
authors.affiliation: From the *Department of Nuclear Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka; †Department of Nuclear Medicine, Faculty of Medicine, Saitama Medical University Hospital, Moroyama; ‡Department of Neuro-Oncology, Saitama International Medical Center, Saitama Medical University, Hidaka; §Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University Hospital, Moroyama; and ∥Department of Pathology, Saitama International Medical Center, Saitama Medical University, Hidaka, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Yamane
authors.forename: Akira
authors.initials: A
authors.lastname: Seto
authors.forename: Tomonari
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yokota
authors.forename: Chih-Ping
authors.initials: CP
authors.lastname: Li
authors.forename: Toshihide
authors.initials: T
authors.lastname: Mimura
authors.forename: Ichiei
authors.initials: I
authors.lastname: Kuji
mesh_terms: D001327:Autoimmune Diseases / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008297:Male; D008715:Methionine; D008875:Middle Aged; D064847:Multimodal Imaging; D009915:Orbit / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D002250:Carbon Radioisotopes; D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine