title: Hedgehog and Resident Vascular Stem Cell Fate.
abstract: The Hedgehog pathway is a pivotal morphogenic driver during embryonic development and a key regulator of adult stem cell self-renewal. The discovery of resident multipotent vascular stem cells and adventitial progenitors within the vessel wall has transformed our understanding of the origin of medial and neointimal vascular smooth muscle cells (SMCs) during vessel repair in response to injury, lesion formation, and overall disease progression. This review highlights the importance of components of the Hh and Notch signalling pathways within the medial and adventitial regions of adult vessels, their recapitulation following vascular injury and disease progression, and their putative role in the maintenance and differentiation of resident vascular stem cells to vascular lineages from discrete niches within the vessel wall.
authors.affiliation: Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Ciaran J
authors.initials: CJ
authors.lastname: Mooney
authors.affiliation: Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Roya
authors.initials: R
authors.lastname: Hakimjavadi
authors.affiliation: Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Emma
authors.initials: E
authors.lastname: Fitzpatrick
authors.affiliation: Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Eimear
authors.initials: E
authors.lastname: Kennedy
authors.affiliation: School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Dermot
authors.initials: D
authors.lastname: Walls
authors.affiliation: Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: David
authors.initials: D
authors.lastname: Morrow
authors.affiliation: Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Redmond
authors.affiliation: Vascular Biology and Therapeutics Laboratory, School of Biotechnology, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Cahill