title: Manganese-Catalyzed Aerobic Oxytrifluoromethylation of Styrene Derivatives Using CF3SO2Na as the Trifluoromethyl Source.
abstract: A mild and practical protocol for manganese-catalyzed aerobic oxytrifluoromethylation of olefinic bonds of styrene derivatives using CF3SO2Na (Langlois' reagent) as the CF3 source is described. A distinguishing feature of this method is the generation of trifluoromethyl radicals from CF3SO2Na using the simple manganese salt/O2 system. The reaction proceeds under ambient conditions, free of added peroxide initiators, and provides moderate to good selectivities for alcohol versus ketone product.
authors.affiliation: ‡Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Yingle
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: ‡Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, United States.
authors.forename: David A
authors.initials: DA
authors.lastname: Vicic
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D008345:Manganese / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D020058:Styrene / Q000138:chemical synthesis*; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000475:Alkenes; D013450:Sulfones; D008345:Manganese; D020058:Styrene