title: Detection of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis patients undergoing total knee arthroplasty.
abstract: Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disorder and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) is regarded as a serological marker for diagnosing early and late RA. In the present study, we aimed to determine the levels of anti-CCP Ab in serum, synovial tissue (ST) and synovial fluid (SF) in RA patients undergoing total knee arthroplasty (TKA). 23 patients were included. Rheumatoid factor (RF) and anti-CCP Ab in serum were detected prior to surgery and then at 1, 3, 6 and 12 months after TKA. Synovial samples were obtained by knee arthroscopy and used for anti-CCP detection. One month after TKA, anti-CCP levels were significantly reduced (P < 0.01) in RA patients. However, their levels were not significantly different between pre-surgery and 1 year post-surgery (P > 0.05). Furthermore, anti-CCP levels in ST were much higher than in serum. These findings suggest that RA patients should continue antirheumatic therapy after TKA. ST is the preferred place for the synthesis of anti-CCP Ab.
authors.affiliation: Department of Orthopedics, Ningxia People's Hospital 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
authors.forename: Chong-Jun
authors.initials: CJ
authors.lastname: Guo
authors.affiliation: Department of Orthopedics, Ningxia People's Hospital 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
authors.forename: Jin-Han
authors.initials: JH
authors.lastname: Lv
authors.affiliation: Department of Orthopedics, Ningxia People's Hospital 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Niu
authors.affiliation: School of Clinical Medicine, Ningxia Medical University Yinchuan 750004, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Orthopedics, General Hospital of Ningxia Medical University Yinchuan 750004, People's Republic of China.
authors.forename: Shou-Xuan
authors.initials: SX
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, Ningxia People's Hospital 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Li
authors.affiliation: School of Clinical Medicine, Ningxia Medical University Yinchuan 750004, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: School of Clinical Medicine, Ningxia Medical University Yinchuan 750004, People's Republic of China.
authors.forename: Long
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Orthopedics, General Hospital of Ningxia Medical University Yinchuan 750004, People's Republic of China.
authors.forename: Qun-Hua
authors.initials: QH
authors.lastname: Jin
keywords: Rheumatoid arthritis; anti-CCP antibody; synovial tissue; total knee arthroplasty