title: Ternary metal complexes of guaifenesin drug: Synthesis, spectroscopic characterization and in vitro anticancer activity of the metal complexes.
abstract: The coordination behavior of a series of transition metal ions named Cr(III), Fe(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with a mono negative tridentate guaifenesin ligand (GFS) (OOO donation sites) and 1,10-phenanthroline (Phen) is reported. The metal complexes are characterized based on elemental analyses, IR, (1)H NMR, solid reflectance, magnetic moment, molar conductance, UV-vis spectral studies, mass spectroscopy, ESR, XRD and thermal analysis (TG and DTG). The ternary metal complexes were found to have the formulae of [M(GFS)(Phen)Cl]Cl·nH2O (M=Cr(III) (n=1) and Fe(III) (n=0)), [M(GFS)(Phen)Cl]·nH2O (M=Mn(II) (n=0), Zn(II) (n=0) and Cu(II) (n=3)) and [M(GFS)(Phen)(H2O)]Cl·nH2O (M=Co(II) (n=0), Ni(II) (n=0) and Cd(II) (n=4)). All the chelates are found to have octahedral geometrical structures. The ligand and its ternary chelates are subjected to thermal analyses (TG and DTG). The GFS ligand, in comparison to its ternary metal complexes also was screened for their antibacterial activity on gram positive bacteria (Bacillus subtilis and Staphylococcus aureus), gram negative bacteria (Escherichia coli and Neisseria gonorrhoeae) and for in vitro antifungal activity against (Candida albicans). The activity data show that the metal complexes have antibacterial and antifungal activity more than the parent GFS ligand. The complexes were also screened for its in vitro anticancer activity against the Breast cell line (MFC7) and the results obtained show that they exhibit a considerable anticancer activity.
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: W H
authors.initials: WH
authors.lastname: Mahmoud
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: N F
authors.initials: NF
authors.lastname: Mahmoud
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: G G
authors.initials: GG
authors.lastname: Mohamed
authors.affiliation: Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt. Electronic address: elsonbatisch@yahoo.com.
authors.forename: A Z
authors.initials: AZ
authors.lastname: El-Sonbati
authors.affiliation: Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: El-Bindary
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006140:Guaifenesin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics; D028561:Transition Elements / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D028561:Transition Elements; D006140:Guaifenesin
keywords: 1,10-Phenanthroline; Biological activity and anticancer activity; Guaifenesin; Ternary metal complexes; Thermal and spectroscopic analyses