title: The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin.
abstract: The excited triplet state of tanshinone I (Tan I) extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge was characterized by laser flash photolysis. The synergic effect of Tan I on the phototherapy of cancer cells with curcumin (Cur) was also investigated by MTT assay because the excited energy transfer from the triplet state of Tan I ((3)Tan I(∗)) to Cur occurred. At the same time, the characteristic absorption spectra of (3)Tan I(∗) were recorded, and its molar absorption coefficient and rate constants for several excited energy transfers were obtained. The photo-therapeutic effect of Cur is enhanced by combination with Tan I.
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China; Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Sun
authors.affiliation: Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai, China. Electronic address: qxw1123@126.com.
authors.forename: Qingxiu
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Tenth People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, PR China; Research Center for Translational Medicine at East Hospital, Tongji University, Shanghai, China. Electronic address: wsl@tongji.edu.cn.
authors.forename: ShiLong
authors.initials: S
authors.lastname: Wang
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D003474:Curcumin / Q000494:pharmacology*; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D004735:Energy Transfer; D006801:Humans; D007834:Lasers; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010782:Photolysis; D010789:Phototherapy / Q000379:methods; D027561:Salvia miltiorrhiza / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; C021751:tanshinone; D003474:Curcumin
keywords: Excited energy transfer; Laser flash photolysis; MTT assay; Rate constant; Synergic effect; Tanshinone I