title: [Blunted erythropoietic response in the anemia of anorexia nervosa].
abstract: OBJECTIVE
  The cause of the anemia in anorexia nervosa (AN) has not been fully ascertained. Ferritin, folate and cobalamin values are usually within normal ranges. Anemia does not have a relationship with bone marrow changes and erythropoietin (EPO) levels have not been investigated. The objective of this study was to evaluate the EPO response in a small group of AN patients.
  
  
  METHODS
  EPO levels were measured in serum samples of 41 female AN patients (11 with anemia, and 30 with normal blood cell count). The adequacy of EPO response was assessed by comparing the increase observed in a group of normal weight patients with anemia.
  
  
  RESULTS
  EPO concentrations in anemic AN patients were higher than in non-anemic: 20.63mU/mL (4.04-28.46) vs 8.7mU/mL (3.9-20.93), P=.0088, but the increase in EPO was lower than expected (27.85mU/mL [17.7-118.9]), P=.014. BMI and the difference between actual and expected EPO were inversely correlated.
  
  
  CONCLUSIONS
  Inadequate EPO response may partly explain anemia in AN, but further studies are necessary.
authors.affiliation: Laboratorio de Hematología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España. Electronic address: jordijunca@comb.cat.
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.affiliation: Laboratorio de Hematología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Marc
authors.initials: M
authors.lastname: Sorigué
authors.affiliation: Laboratorio de Hematología, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Inés
authors.initials: I
authors.lastname: Rodríguez-Hernández
authors.affiliation: Laboratorio de Análisis Clínicos, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Marta
authors.initials: M
authors.lastname: Aldea
authors.affiliation: Laboratorio de Análisis Clínicos, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Granada
authors.affiliation: Servicio de Psiquiatría, Hospital Germans Trias i Pujol, Badalona, Barcelona, España.
authors.forename: Lluis
authors.initials: L
authors.lastname: Sánchez-Planell
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology*; D000856:Anorexia Nervosa / Q000097:blood / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D004921:Erythropoietin / Q000097:blood / Q000172:deficiency*; D005260:Female; D006801:Humans; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004921:Erythropoietin
keywords: Anemia; Anorexia nerviosa; Anorexia nervosa; Eritropoyetina; Erythropoietin