title: Microparticle entrapment for drug release from porous-surfaced bone implants.
abstract: Metallic bone implants face interfacial concerns, such as infection and insufficient bone formation. Combination of drug-loaded microparticles with the implant surface is a promising approach to reducing the concerns. The present study reports a simple method for this purpose. Drug-loaded chitosan and alginate microparticles were separately prepared by emulsion methods. Dry microparticles were introduced into porous titanium (Ti) coatings on Ti discs, and induced to agglomerate in pores by wetting with water. Agglomerates were stably entrapped in the pores: 77-82% retained in the coating after immersion in a water bath for 7 d. Discs carrying drug-loaded microparticles showed a rapid release within 6 h and a subsequent slow release up to 1 d. After coculture with Staphylococcus epidermidis for 24 h, the discs formed inhibition zones, confirming antibacterial properties. These suggest that the microparticle entrapment-based method is a promising method for reducing some of the bone-implant interfacial concerns.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu, Sichuan , China and.
authors.forename: Dongwei
authors.initials: D
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Dongqin
authors.initials: D
authors.lastname: Xiao
authors.forename: Tailin
authors.initials: T
authors.lastname: Guo
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Ma
authors.forename: Ke
authors.initials: K
authors.lastname: Duan
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wang
authors.forename: Xiong
authors.initials: X
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Feng
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018786:Bone Substitutes / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D004343:Drug Implants / Q000737:chemistry / Q000494:pharmacology; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D016062:Porosity; D013212:Staphylococcus epidermidis / Q000254:growth & development*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D006603:Hexuronic Acids; D020723:Glucuronic Acid
keywords: Antibiotics; bone implant; drug release; microparticles; surface