title: Biosynthesis of caffeine underlying the diversity of motif B' methyltransferase.
abstract: Caffeine (1,3,7-trimethylxanthine) and theobromine (3,7-dimethylxanthine) are well-known purine alkaloids in Camellia, Coffea, Cola, Paullinia, Ilex, and Theobroma spp. The caffeine biosynthetic pathway depends on the substrate specificity of N-methyltransferases, which are members of the motif B' methyl-transferase family. The caffeine biosynthetic pathways in purine alkaloid-containing plants might have evolved in parallel with one another, consistent with different catalytic properties of the enzymes involved in these pathways.
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Nakayama
authors.forename: Kouichi
authors.initials: K
authors.lastname: Mizuno
authors.forename: Misako
authors.initials: M
authors.lastname: Kato
mesh_terms: D020816:Amino Acid Motifs; D002110:Caffeine / Q000096:biosynthesis*; D014644:Genetic Variation; D008780:Methyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D002110:Caffeine; D008780:Methyltransferases