title: Increased CD1D polymorphism: identification of two novel alleles, CD1D*03 and *04, in individuals from Morocco.
abstract: Two novel CD1D alleles were identified in unrelated individuals from Morocco. They differ each from the common CD1D*01 allele by one nucleotide substitution in exon 2 resulting in one amino acid change in the G-ALPHA1-LIKE domain. According to the IMGT unique numbering for G domain, CD1D*03 has one nucleotide transition c136 > t in codon 46, with an arginine-to-cysteine amino acid change (R46 > C) in the D-STRAND, whereas CD1D*04 has one transition c98 > t in codon 33, with a threonine-to-methionine amino acid change (T33 > M) in the C-STRAND. This suggests that CD1D is more polymorphic than previously assumed.
authors.affiliation: CNR, Institute of Translational Pharmacology (IFT), UOS L'Aquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Aureli
authors.affiliation: Laboratoire d'Immunologie, Institut National d'Hygiene, Rabat, Morocco.
authors.forename: K
authors.initials: K
authors.lastname: Oumhani
authors.affiliation: CNR, Institute of Translational Pharmacology (IFT), UOS L'Aquila, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Del Beato
authors.affiliation: CNR, Institute of Translational Pharmacology (IFT), UOS L'Aquila, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Di Rocco
authors.affiliation: Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tessitore
authors.affiliation: Laboratoire d'Immunologie, Institut National d'Hygiene, Rabat, Morocco.
authors.forename: R
authors.initials: R
authors.lastname: El Aouad
authors.affiliation: CNR, Institute of Translational Pharmacology (IFT), UOS L'Aquila, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Piancatelli
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D055610:Antigens, CD1d / Q000235:genetics*; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D009018:Morocco; D011110:Polymorphism, Genetic; D011487:Protein Conformation; D017422:Sequence Analysis, DNA
chemical_list: D055610:Antigens, CD1d; C526877:CD1D protein, human