title: Imaging Genomics of Glioblastoma: Biology, Biomarkers, and Breakthroughs.
abstract: Glioblastoma is regarded as the most aggressive and most common primary malignant brain tumor in adults. Despite advancements in chemotherapy and radiotherapy, prognosis and overall survival of glioblastoma patients remain dismal. Recently, progresses in genetic profiling have increased our understanding of the underlying heterogenous molecular nature of this aggressive tumor. Several prognostic and predictive molecular biomarkers have been identified that have been linked to patient's survival and response to treatment, respectively. Imaging genomics represents a novel entity in clinical sciences that bidirectionally links imaging features with underlying molecular profile and thus can serve as a surrogate for noninvasive genomic correlation, prediction, and identification.
authors.affiliation: From the *Department of Diagnostic and Radiology, University of Texas, MD Anderson Cancer Center; †Department of Neurosurgery and Baylor College of Medicine; and ‡ Department of Cancer Systems Imaging, University of Texas, MD Anderson Cancer Center, Houston, TX.
authors.forename: Safwan
authors.initials: S
authors.lastname: Moton
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elbanan
authors.forename: Pascal O
authors.initials: PO
authors.lastname: Zinn
authors.forename: Rivka R
authors.initials: RR
authors.lastname: Colen
mesh_terms: D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D023281:Genomics / Q000379:methods*; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D014408:Biomarkers, Tumor