title: [Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke].
abstract: There are results of the determination of 10 polymorphisms of matrix Gla-protein system (gene MGP-T(-138)-->C (rs1800802), G(-7)-->A (rs1800801), Thr83-->Ala (rs4236), gene VDR-FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), gene GGCX-Arg325-->Gln (rs699664), gene VKORS1-T(2255)-->C (rs2359612), gene BMP-2-Ser37-->Ala (rs2273073)) into 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy individual is (control group). It is established that there is a connection between the IATS and polymorphic variants of genes MGP (G(-7)-->A) and VKORC1 (T(2255)-->C). The risk of IATS in carriers of minor allele A/A (G(-7)-->A polymorphism) in 2.6 times higher than in carriers of the major allele (G/A + G/G), and C/C genotype (T(2255)-->C polymorphism) in 2.2 times higher than the homozygotes of major allele. The coincidence of patients T/C and G/G, C/C and G/A genotypes, and A/A genotype (G(-7)-->A polymorphism) with any genotype T(2255)-->C polymorphism are increases the risk of IATS.
authors.forename: V Yu
authors.initials: VY
authors.lastname: Garbuzova
authors.forename: D A
authors.initials: DA
authors.lastname: Stroy
authors.forename: V E
authors.initials: VE
authors.lastname: Dosenko
authors.forename: Ye I
authors.initials: YI
authors.lastname: Dubovyk
authors.forename: A O
authors.initials: AO
authors.lastname: Borodenko
authors.forename: K A
authors.initials: KA
authors.lastname: Shimko
authors.forename: O A
authors.initials: OA
authors.lastname: Obukhova
authors.forename: O V
authors.initials: OV
authors.lastname: Ataman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics* / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000235:genetics*; D016022:Case-Control Studies; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D020767:Intracranial Thrombosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics; D012306:Risk; D020521:Stroke / Q000235:genetics* / Q000473:pathology; D064417:Vitamin K Epoxide Reductases / Q000235:genetics*; D000097568:Matrix Gla Protein
chemical_list: D055396:Bone Morphogenetic Protein 2; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D018167:Receptors, Calcitriol; D064417:Vitamin K Epoxide Reductases; D000097568:Matrix Gla Protein; C525718:BMP2 protein, human; C579457:VDR protein, human; C578523:VKORC1 protein, human