title: Aortic Intima-Media Thickness as an Early Marker of Atherosclerosis in Children With Inflammatory Bowel Disease.
abstract: OBJECTIVE
  The aims of this study were to determine the presence of endothelial dysfunction by measuring aortic intima-media thickness (aIMT) and carotid intima-media thickness (cIMT) and to evaluate the role of traditional risk factors for premature atherosclerosis in children with inflammatory bowel disease (IBD).
  
  
  METHODS
  Thirty-four children with IBD (25 Crohn disease [CD] and 9 ulcerative colitis [UC]; mean age 11.1 years) and 27 healthy subjects matched for sex and age were enrolled. In all of the patients, demographic characteristics and risk factors for atherosclerosis (age, sex, body mass index, blood pressure, dyslipidemia, active and passive smoking, and family history for cardiovascular diseases), CD and UC clinical activity scores, and inflammatory markers were evaluated. aIMT and cIMT were measured by high-resolution B-mode ultrasound.
  
  
  RESULTS
  aIMT was significantly higher in patients than in controls (P < 0.0005). No significant differences were found for cIMT, although the carotid thickness was higher in patients with IBD than in healthy subjects. At a univariate analysis, inflammatory markers levels and tobacco smoking exposure were significantly related to higher aIMT values, whereas in a multivariate regression model, the inflammatory status was the only independent variable correlated with high aIMT.
  
  
  CONCLUSIONS
  aIMT is an earlier marker of preclinical atherosclerosis than cIMT in young children with active IBD. The inflammatory status and the smoking exposure are significantly correlated with the premature endothelial dysfunction. These data emphasize the importance of controlling the chronic intestinal inflammation and endorsing smoke-free environments for children and adolescents with IBD.
authors.affiliation: *Pediatric Gastroenterology and Liver Unit, Department of Pediatrics †Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Aloi
authors.forename: Luciana
authors.initials: L
authors.lastname: Tromba
authors.forename: Valentina
authors.initials: V
authors.lastname: Rizzo
authors.forename: Giulia
authors.initials: G
authors.lastname: D'Arcangelo
authors.forename: Anna
authors.initials: A
authors.lastname: Dilillo
authors.forename: Sara
authors.initials: S
authors.lastname: Blasi
authors.forename: Fortunata
authors.initials: F
authors.lastname: Civitelli
authors.forename: Dimitra
authors.initials: D
authors.lastname: Kiltzanidi
authors.forename: Adriano
authors.initials: A
authors.lastname: Redler
authors.forename: Franca
authors.initials: F
authors.lastname: Viola
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000473:pathology*; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D015415:Biomarkers; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008297:Male; D012307:Risk Factors
chemical_list: D015415:Biomarkers