title: Current perspectivesin pathogenesis and antimicrobial resistance of enteroaggregative Escherichia coli.
abstract: Enteroaggregative Escherichia coli (EAEC) is an emerging pathogen that causes acute and persistent diarrhea in children and adults. While the pathogenic mechanisms of EAEC intestinal colonization have been uncovered (including bacterial adhesion, enterotoxin and cytotoxin secretion, and stimulation of mucosal inflammation), those of severe extraintestinal infections remain largely unknown. The recent emergence of multidrug resistant EAEC represents an alarming public health threat and clinical challenge, and research on the molecular mechanisms of resistance is urgently needed.
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, PR China.
authors.forename: Haishen
authors.initials: H
authors.lastname: Kong
authors.affiliation: Department of Laboratory Medicine, SGCC Occupational Disease Prevention and Treatment Hospital, Jiande, 311600, PR China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hong
authors.affiliation: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, PR China. Electronic address: zylixf@126.com.
authors.forename: Xuefen
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents
keywords: Enteroaggregative Escherichia coli; Escherichia coli; Multidrug-resistant; Pathogenicity