title: Effect of atovastatin treatment on porcine circovirus 2 infection in BALB/c mice.
abstract: The HMG-CoA reductase (HMGCR) pathway is an important metabolic route, which is not only present in almost every organism, but also involves virus infection. It has recently been shown that expression levels of IFN-responsive genes were significantly increased in HMGCR-downregulated cells and HMGCR inhibitor-treated cells. The aim of this study was to determine whether inhibition of HMGCR by atovastatin would significantly affect Porcine circovirus type 2 (PCV2) infection and immunological reaction in BALB/c mice. The results showed atovastatin significantly stimulated PCV2 replication in vivo. Immunological reaction in atovastatin-treated mice was also significantly enhanced during PCV2 infection. Atovastatin also enhanced PCV2-induced illness in mice. The results of this study will provide new insight into the role of atovastatin in PCV2 infection.
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Ouyang
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Fuwang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Peng
authors.affiliation: The Chinese Peoples' Liberation Army 208 Hospital, Changchun, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.affiliation: Heping Campus, Jilin University, Changchun, Jilin, China.
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Boyu
authors.initials: B
authors.lastname: Li
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Daxing
authors.initials: D
authors.lastname: Pang
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Changchun, Jilin, China.
authors.forename: Linzhu
authors.initials: L
authors.lastname: Ren
mesh_terms: D000818:Animals; D000069059:Atorvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D018173:Circoviridae Infections / Q000188:drug therapy* / Q000276:immunology; D017925:Circovirus / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000069059:Atorvastatin
keywords: BALB/c mice; HMG-CoA reductase (HMGCR); atovastatin; infection; porcine circovirus 2 (PCV2)