title: The catechol-o-methyltransferase Val¹⁵⁸Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.
abstract: The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition.
authors.affiliation: Brainnetome Center.
authors.forename: Xiaolong
authors.identifier: 0000000302627854
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1] Brainnetome Center [2] National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Wen
authors.identifier: 0000000291218296
authors.initials: W
authors.lastname: Qin
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: 1] Brainnetome Center [2] National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: 1] Brainnetome Center [2] National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China [3] Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia [4] Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
authors.forename: Tianzi
authors.initials: T
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002540:Cerebral Cortex / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D005260:Female; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D020534:Parahippocampal Gyrus / Q000378:metabolism / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase