title: The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases.
abstract: The end of twentieth century has introduced some changes into T helper (Th) cells division. The identification of the new subpopulation of T helper cells producing IL-17 modified model of Th1-Th2 paradigm and it was named Th17. High abilities to stimulate acute and chronic inflammation made these cells ideal candidate for crucial player in development of autoimmune disorders. Numerous publications based on animal and human models confirmed their pivotal role in pathogenesis of human systemic and organ-specific autoimmune diseases. These findings made Th17 cells and pathways regulating their development and function a good target for therapy. Therapies based on inhibition of Th17-dependent pathways are associated with clinical benefits, but on the other hand are frequently inducing adverse effects. In this review, we attempt to summarize researches focused on the importance of Th17 cells in development of human autoimmune diseases as well as effectiveness of targeting IL-17 and its pathways in pre-clinical and clinical studies.
authors.affiliation: Centre for Innovative Research in Medical and Natural Sciences, Medical Faculty, University of Rzeszów, Rzeszow, Poland. jacek.tabarkiewicz@gmail.com.
authors.forename: Jacek
authors.initials: J
authors.lastname: Tabarkiewicz
authors.affiliation: Centre for Innovative Research in Medical and Natural Sciences, Medical Faculty, University of Rzeszów, Rzeszow, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pogoda
authors.affiliation: Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Karczmarczyk
authors.affiliation: Department of Clinical Immunology, Medical University of Lublin, Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Pozarowski
authors.affiliation: Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Giannopoulos
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D058408:Th1-Th2 Balance; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17
keywords: Autoimmune diseases; IL-17; Th17; Therapy