title: Uterine Cystic Adenomyosis: A Disease of Younger Women.
abstract: OBJECTIVE
  We adopted a life-cycle approach to further our understanding of the natural history of the cystic forms of uterine adenomyosis first described by Cullen in 1908.
  
  
  METHODS
  Scopus and PubMed were searched for all terms referring to cystic variant of adenomyosis or adenomyoma. References found in major publications were also included in the review.
  
  
  RESULTS
  With the introduction of non-invasive imaging techniques, a number of cases of cystic variants of adenomyosis have been reported. Progressive, severe, medication-resistant dysmenorrhea is the main clinical feature but delay in diagnosis remains problematic. The life-cycle approach demonstrates that cystic adenomyosis is more relevant to adolescent and young adulthood. Congenital müllerian and wolffian cysts and the uterus-like masses are more frequent in women >30 years of age. The latter is frequently located outside the uterus and may represent a form of endometriosis rather than adenomyosis. Differential diagnosis includes ovarian cysts and congenital uterine anomalies. Menstruation suppression with continuous oral contraceptive pill with ultrasonographic monitoring of cyst regression may prove successful in the young woman, but surgical excision using minimally invasive endoscopy is highly effective. The various terms used in literature to describe these lesions cause considerable confusion. Here we propose a classification into 3 subtypes and standardized reporting criteria to enable comparison.
  
  
  CONCLUSIONS
  Endometrial lined myometrial cysts are almost specific to adolescent and young women. We propose a new classification system.
authors.affiliation: Catholic University of Leuven, Leuven, Belgium. Electronic address: ivo.brosens@med.kuleuven.be.
authors.forename: Ivo
authors.initials: I
authors.lastname: Brosens
authors.affiliation: Leuven Institute for Fertility and Embryology, Leuven, Belgium.
authors.forename: Stephan
authors.initials: S
authors.lastname: Gordts
authors.affiliation: Reproductive Sciences Section, University of Leicester and University Hospitals of Leicester, Leicester, UK.
authors.forename: Marwan
authors.initials: M
authors.lastname: Habiba
authors.affiliation: Department of Gynecology, Obstetrics and Urology, Sapienza University, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Benagiano
mesh_terms: D062788:Adenomyosis / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D000293:Adolescent; D003277:Contraceptives, Oral, Combined; D003560:Cysts / Q000145:classification / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D003277:Contraceptives, Oral, Combined
keywords: Adolescent; Cystic adenomyosis; Dysmenorrhea; Myometrial cyst