title: Immune reconstitution inflammatory syndrome in a patient with progressive multifocal leukoencephalopathy.
abstract: Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic infection of the central nervous system. A 52-year-old man with HIV infection, recently started on antiretroviral therapy, presented with symptoms of mental cloudiness, blurry vision and ataxia. MRI of the brain showed nodular perivascular space enhancement with surrounding vasogenic oedema and midline shift. A lumbar puncture revealed non-inflammatory cerebrospinal fluid and was positive for JC virus. As the patient developed worsening symptoms in the setting of initiation of antiretroviral therapy with immune recovery, a diagnosis of JC virus-associated immune reconstitution inflammatory syndrome (IRIS) was made. With recent literature on the use of CCR5 antagonist maraviroc in PML, our patient was started on maraviroc and noted to have improvement in PML IRIS. This is the first case of an HIV-positive patient successfully treated for PML IRIS with maraviroc, as verified by our literature review; also, our case has clinical implications in improving outcome in PML IRIS.
authors.affiliation: Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Lokesh
authors.initials: L
authors.lastname: Shahani
authors.affiliation: Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Minal
authors.initials: M
authors.lastname: Shah
authors.affiliation: Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Tavakoli-Tabasi
mesh_terms: D065100:CCR5 Receptor Antagonists / Q000627:therapeutic use*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D003510:Cyclohexanes / Q000627:therapeutic use*; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D007577:JC Virus / Q000276:immunology*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D000077592:Maraviroc; D008875:Middle Aged; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D014230:Triazoles; D000077592:Maraviroc