title: Compare and contrast: a cross-national study across UK, USA and Greek experts regarding return of incidental findings from clinical sequencing.
abstract: Return of incidental findings (IFs) from clinical sequencing has become a hotly debated topic over the past year. Efforts are being made by several bodies to provide guidance at both national and international levels; however, no studies comparing attitudes of experts across different countries have been published so far. Our goal was to investigate attitudes towards return of IFs from clinical sequencing across UK, USA and Greek experts. Thirty in-depth interviews were conducted with genetics and genomic experts with different backgrounds. Our study revealed more differences when experts were compared according to their professional background than their country. General principles guiding the decision-making and the feedback process were common across all experts but the details of integrating these tests might vary as different professionals reported different needs and attitudes.
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, UK.
authors.forename: Elli G
authors.initials: EG
authors.lastname: Gourna
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, UK.
authors.forename: Natalie
authors.initials: N
authors.lastname: Armstrong
authors.affiliation: Department of Health Sciences, University of Leicester, Leicester, UK.
authors.forename: Susan E
authors.identifier: http://orcid.org/0000-0002-2995-1673
authors.initials: SE
authors.lastname: Wallace
mesh_terms: D059472:Exome / Q000235:genetics; D005104:Expert Testimony; D006115:Greece; D006801:Humans; D033162:Incidental Findings; D007258:Informed Consent; D017422:Sequence Analysis, DNA / Q000379:methods*; D006113:United Kingdom; D014481:United States