title: Ascites and other incidental findings revealing undiagnosed systemic rheumatoid arthritis.
abstract: We describe a case of a 43-year-old man presenting to the gastroenterology outpatient department with exudative ascites. Mediastinal lymphadenopathy, pericardial effusion and pleural effusion were detected on further imaging. Further clinical examination revealed subcutaneous nodules on the left arm, which were confirmed to be rheumatoid nodules on histology. Inflammatory markers were elevated with positive serology for rheumatoid factor and anticyclic citrullinated protein antibody. Our investigations excluded tuberculosis, pancreatitis and malignancy in the patient. Following review by a rheumatologist, a diagnosis of systemic rheumatoid arthritis (RA) was made. Pleuritis and pericarditis are well recognised as extra-articular manifestation of RA. Ascites, however, is rarely recognised as a manifestation of RA. Our literature search revealed two other cases of ascites due to RA disease activity, and both patients had long-standing known RA. This case adds to the discussion on whether ascites and peritonitis should be classified as extra-articular manifestations of RA.
authors.affiliation: George Elliot Hospital, Nuneaton, UK.
authors.forename: Matthew Chak Hin
authors.initials: MC
authors.lastname: Szeto
authors.affiliation: George Elliot Hospital, Nuneaton, UK.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Disney
authors.affiliation: Department of Rheumatology, University Hospital Coventry and Warwickshire, Coventry, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Perkins
authors.affiliation: Department of Gastroenterology, George Elliot Hospital, Nuneaton, UK.
authors.forename: Gordon
authors.initials: G
authors.lastname: Wood
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D001201:Ascites / Q000209:etiology*; D006801:Humans; D033162:Incidental Findings; D008111:Liver Function Tests; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009288:Naproxen / Q000627:therapeutic use; D010490:Pericardial Effusion / Q000209:etiology; D010996:Pleural Effusion / Q000209:etiology; D011239:Prednisolone / Q000627:therapeutic use; D012017:Referral and Consultation; D012217:Rheumatoid Factor / Q000097:blood*; D012218:Rheumatoid Nodule / Q000150:complications / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; D009288:Naproxen; D012217:Rheumatoid Factor; D011239:Prednisolone; D008727:Methotrexate