title: Thermodynamic insights into drug-surfactant interactions: Study of the interactions of naporxen, diclofenac sodium, neomycin, and lincomycin with hexadecytrimethylammonium bromide by using isothermal titration calorimetry.
abstract: The success of drug delivery depends on the efficiency of the route of administration, which in turn relies on properties of the drug and its transport vehicle. A quantitative knowledge of association of drugs with transport vehicles is lacking when the latter are in the category of self assembled structures. The work reported in this manuscript addresses the mechanism of partitioning of naproxen, diclofenac sodium, neomycin and lincomycin in the micelles of hexadecytrimethylammonium bromide and that is quantitatively based on the measurement of thermodynamic parameters of interactions by using isothermal titration calorimetry. The addressed mechanism of partitioning is based on the identification of the type of interactions of these drugs with the surfactant micelles and monomers, along with the effect of the former on the micellization properties of the surfactant. The conclusions are based on the interpretation of the values of partitioning constant, standard molar enthalpy change, standard molar entropy change and the stoichiometry of the interaction. The results of this study have implications for deriving guidelines for the target oriented synthesis of new drugs that are to be used for effective delivery via micellar media.
authors.affiliation: University of Mumbai, Department of Atomic Energy, Centre for Excellence in Basic Sciences, Santacruz (E), Mumbai 400 098, India. Electronic address: sinjan.choudhary@cbs.ac.in.
authors.forename: Sinjan
authors.initials: S
authors.lastname: Choudhary
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India. Electronic address: paurnima@chem.iitb.ac.in.
authors.forename: Paurnima
authors.initials: P
authors.lastname: Talele
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India. Electronic address: nandk@chem.iitb.ac.in.
authors.forename: Nand
authors.initials: N
authors.lastname: Kishore
mesh_terms: D002151:Calorimetry / Q000379:methods*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry*; D004008:Diclofenac / Q000737:chemistry; D008034:Lincomycin / Q000737:chemistry; D008823:Micelles; D009288:Naproxen / Q000737:chemistry; D009355:Neomycin / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D002593:Cetrimonium Compounds; D008823:Micelles; D004364:Pharmaceutical Preparations; D013501:Surface-Active Agents; D004008:Diclofenac; D009288:Naproxen; D008034:Lincomycin; D009355:Neomycin; D000077286:Cetrimonium
keywords: Drug delivery; Drug-partitioning; Isothermal titration calorimetry, Cationic surfactant; Micelles