title: Primary Enteropathy-Associated T-Cell Lymphoma Type 2: An Emerging Entity?
abstract: Intestinal T-cell lymphoma is a rare hematological malignancy that can present as primary intestinal lymphoma or as a manifestation of systemic disease. Primary involvement accounts for approximately 0.1% to 0.5% of all colorectal neoplasms. It is an aggressive disease with a poor prognosis and low survival rate. Inflammatory bowel disease, celiac disease, immunosuppression, and infectious etiologies, such as Epstein-Barr and human T-lymphotropic viruses, have been reported as risk factors, but no direct causal link has been established. Herein, we examine the case of a Hispanic man 69 years of age diagnosed with positive CD3, CD7, CD8, CD43, and Bcl-2 diffuse primary colorectal T-cell lymphoma. The patient did not exhibit a concomitant autoimmune or genetic disease. Because of the patient's history of polyps, surveillance colonoscopy was performed and the diagnosis was confirmed.
authors.affiliation: VA Caribbean Healthcare System, 10 Casia Street, San Juan, PR 00921. Doris.Toro@va.gov.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Grigg-Gutierrez
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Estremera-Marcial
authors.forename: William W
authors.initials: WW
authors.lastname: Caceres
authors.forename: Doris H
authors.initials: DH
authors.lastname: Toro
mesh_terms: D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D058527:Enteropathy-Associated T-Cell Lymphoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male