title: Childhood Hepatosplenic T-cell Lymphoma with Skin Involvement.
abstract: BACKGROUND
  Hepatosplenic T-cell lymphoma is a rare malignancy in childhood.
  
  
  METHODS
  A 12-year-old boy who presented a pyrexia of unknown origin, multiple skin and lesions and marked hepatosplenomegaly.
  
  
  METHODS
  Bone marrow aspirate cytology showed no blast cells. Splenectomy was done, and spleen showed infiltration with atypical lymphoid cells positive for CD3, CD8 and T-cell-restricted intracellular antigen.
  
  
  RESULTS
  The skin rash of patient subsided with chemotherapy.
  
  
  CONCLUSIONS
  Skin involvement may be an unusual clinical manifestation of hepatosplenic T-cell lymphoma.
authors.affiliation: Department of Pediatric Hematology Oncology and Key Laboratory of Birth Defect and Related Disease of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Correspondence to: Dr Qiang Li, No. 20, Sec. 3, Ren Min Nan Lu, Chengdu, 610041, China. 18681373671@163.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Guo
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Zhu
mesh_terms: D002648:Child; D006801:Humans; D008113:Liver Neoplasms; D016399:Lymphoma, T-Cell; D008297:Male; D012867:Skin / Q000473:pathology*; D013160:Splenic Neoplasms