title: Association study of dopamine transporter gene (DAT1) variable tandem repeat sequence (VNTR) with obsessive-compulsive disorder in Chinese Han Population.
abstract: OBJECTIVE
  Multiple evidence suggests an involvement of the dopamine neurotransmitter system in Obsessive-compulsive disorder (OCD). Therefore, we explore the association of 3'UTR region of 40 bp variable tandem repeat (VNTR) polymorphism in Dopamine Transporter Gene (DAT1) in Chinese Han population.
  
  
  METHODS
  A total of 305 OCD patients and 435 healthy individuals were recruited for the study. OCD was diagnosed with the Forth Edition (DSM-IV) diagnostic criteria. After polymerase chain reaction of VNTR was used to evaluate the 40 bp VNTR polymorphism in DAT1, a case-control association analysis was performed by the χ(2) test.
  
  
  RESULTS
  The results showed that no association was found between OCD patients and controls for the genotype distribution (X(2) =0.743, P=0.690, df=2) as well as allelic (X(2)=0.172, P=0.678, OR=0.928, 95% Cl=0.885-1.224) distribution.
  
  
  CONCLUSIONS
  Our data suggest that the 40 bp VNTR polymorphism in DAT1 may not be associated with susceptibility to OCD in the Chinese Han population studied. However, this result needed to be replicated from different populations.
authors.affiliation: Clinical Laboratory, The Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Medical College, Qingdao University Qingdao, 266021, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Reproductive Medicine Centre, The Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Xiuming
authors.initials: X
authors.lastname: Tang
authors.affiliation: The Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Quanchen
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, 266003, China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, Pingyi Hospital Chinese Medicine Shandong, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Gui
authors.affiliation: Department of Psychiatry, Medical College, Qingdao University Qingdao, 266021, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University Qingdao, 266003, China ; Genetic Laboratory, The Affiliated Hospital of Qingdao University Qingdao 266003, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
keywords: 40 bp VNTR; DAT1; OCD; association analysis; susceptibility