title: Decreased pulmonary function in school children in Western Japan after exposures to Asian desert dusts and its association with interleukin-8.
abstract: The objective of the study was to investigate the influence of Asian dust storms (ADS) on pulmonary function of school children and the relationship of this effect with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children from April to May 2012 and in 384 of these children from March to May 2013. The data were analyzed for an association between ADS events and PEF by linear mixed models. Interleukin-8 transcriptional activity was assessed in THP-G8 cells stimulated by airborne particles collected on ADS days. Seven ADS days were identified: April 23 and 24, 2012; March 8 to 10, 2013; and March 19 and 20, 2013. Changes in PEF after ADS exposure were -8.17 L/min (95% confidence interval, -11.40 to -4.93) in 2012 and -1.17 L/min (-4.07 to 1.74) in 2013, and there was a significant difference between 2012 and 2013. Interleukin-8 transcriptional activity was significantly higher in 2012 at 10.6 ± 2.9-fold compared to 3.7 ± 0.4 in March 8 to 10, 2013, and 2.3 ± 0.2 in March 19 and 20, 2013. The influence of ADS events on pulmonary function of children differs with each ADS event and may be related to interleukin-8 production.
authors.affiliation: Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Masanari
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: Department of Data Science, Institute of Statistical Mathematics, Tokyo 190-8562, Japan.
authors.forename: Hisashi
authors.identifier: 0000-0002-2520-9949
authors.initials: H
authors.lastname: Noma
authors.affiliation: Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kurai
authors.affiliation: Department of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, Osakasayama 589-8511, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sano
authors.affiliation: Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8574, Japan.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Saito
authors.affiliation: Chromosome Engineering Research Center, Tottori University, Tottori 683-8504, Japan.
authors.forename: Satoshi
authors.identifier: 0000-0003-1153-0720
authors.initials: S
authors.lastname: Abe
authors.affiliation: Chromosome Engineering Research Center, Tottori University, Tottori 683-8504, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Chromosome Engineering Research Center, Tottori University, Tottori 683-8504, Japan.
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Oshimura
authors.affiliation: Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yamasaki
authors.affiliation: Department of Respiratory Medicine and Rheumatology, Tottori University Hospital, Yonago 683-8504, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
mesh_terms: D044466:Asian People; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D055867:Cyclonic Storms; D004391:Dust; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D007564:Japan; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D012129:Respiratory Function Tests; D014158:Transcription, Genetic
chemical_list: C508606:CXCL8 protein, human; D004391:Dust; D016209:Interleukin-8