title: [Local level of neoangiogenesis factors in dynamics of experimental metastatic process in liver].
abstract: The aim--to study the dynamics content of VEGF-A, VEGF-R1, EGF and EGF-R1 in liver and spleen tissues from rats at different stages of liver metastases.
  
  
  METHODS
  We have designed a model of liver metastases in male rats. The content of growth factors was examined by ELISA at 1, 2 and 5 weeks of carcinogenesis in tissue of liver and tumors of spleen.
  
  
  RESULTS
  The content of growth factors increased in liver tissue at different stages of metastasis. The concentration of VEGF-A increased gradually from the 1st to 5th week carcinogenesis. The concentration of VEGF-R1 increased after 2 weeks and decreased slightly after 5 weeks of carcinogenesis. The level of all components of EGF/EGF-R1 increased after 2 weeks of carcinogenesis.
  
  
  CONCLUSIONS
  The following pathogenetic aspects of liver metastasis were defined: change in levels of VEGF-A/VEGF-R1 indicating the progressive development of the process of neoangiogenesis, and increased levels of EGF/EGF-R1 responsible for metastasis processes.
authors.forename: E M
authors.initials: EM
authors.lastname: Frantsiiants
authors.forename: I V
authors.initials: IV
authors.lastname: Kaplieva
authors.forename: L K
authors.initials: LK
authors.lastname: Trepitaki
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Pogorelova
authors.forename: I I
authors.initials: II
authors.lastname: Gorina
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D051381:Rats; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D013154:Spleen / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D013160:Splenic Neoplasms / Q000098:blood supply / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor