title: Evaluation of primary open-angle glaucoma clinical practice guidelines.
abstract: OBJECTIVE
  To evaluate the methodologic quality of 3 primary open-angle glaucoma (POAG) clinical practice guidelines (CPGs).
  
  
  METHODS
  The CPGs were assessed with the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument.
  
  
  METHODS
  Four authors (A.M.W., C.M.W., B.K.Y., D.J.W.) performed independent assessments of POAG CPGs.
  
  
  METHODS
  POAG CPGs published by the American Academy of Ophthalmology (AAO), Canadian Ophthalmological Society (COS), and National Institute for Health and Care Excellence (NICE) were appraised using the AGREE II instrument's 6 domains (Scope and Purpose, Stakeholder Involvement, Rigor of Development, Clarity of Presentation, Applicability, and Editorial Independence) and Overall Assessment score summarizing guideline quality across all domains.
  
  
  RESULTS
  Scores ranged from 28% to 85% for the AAO CPG, 51% to 96% for the COS CPG, and 55% to 97% for the NICE CPG. Intraclass correlation coefficients for the reliability of mean scores for the AAO, COS, and NICE CPGs were 0.89, 0.86, and 0.74; 95% CIs were 0.80 to 0.95, 0.74 to 0.93, and 0.51 to 0.87, respectively. The strongest domains were Scope and Purpose (AAO, COS, NICE) and Clarity of Presentation (COS, NICE). The weakest domains were Stakeholder Involvement (AAO, COS) and Editorial Independence (AAO, COS, NICE).
  
  
  CONCLUSIONS
  Future POAG CPGs can be improved by addressing potential conflicts of interest within the development group, ensuring transparency of guideline development methodology, and involving all relevant stakeholders in guideline development and review.
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>
authors.forename: Annie M
authors.initials: AM
authors.lastname: Wu
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>
authors.forename: Connie M
authors.initials: CM
authors.lastname: Wu
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>
authors.forename: Benjamin K
authors.initials: BK
authors.lastname: Young
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Wu
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>
authors.forename: Allison
authors.initials: A
authors.lastname: Chen
authors.affiliation: Departments of Ophthalmology, Pathology, and Cell Biology, Morsani College of Medicine, Tampa, Fl.
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Margo
authors.affiliation: Section of Ophthalmology, Providence VA Medical Center; Division of Ophthalmology, Warren Alpert Medical School of Brown University; Division of Ophthalmology, Rhode Island Hospital, Providence, RI?>. Electronic address: paul_greenberg@brown.edu.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Greenberg
mesh_terms: D000047:Academies and Institutes / Q000592:standards*; D002170:Canada; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D009316:National Institutes of Health (U.S.) / Q000592:standards*; D009885:Ophthalmology / Q000592:standards*; D017410:Practice Guidelines as Topic / Q000592:standards*; D011786:Quality Control; D011787:Quality of Health Care / Q000592:standards; D012955:Societies, Medical / Q000592:standards*; D014065:Tonometry, Ocular; D014481:United States