title: Phase-Shifted PFH@PLGA/Fe3O4 Nanocapsules for MRI/US Imaging and Photothermal Therapy with near-Infrared Irradiation.
abstract: Photothermal therapy (PTT) utilizes photothermal conversion reagents to generate heat energy from absorbed light to effectively treat various malignant diseases. This approach has attracted broad and increasing interest in cancer treatment. Near-infrared (NIR)-induced PTT is particularly attractive because of its minimal absorbance by normal tissue and relatively deep tissue penetration. To improve the efficacy of PTT, we have developed nanocapsules encapsulating superparamagnetic iron oxide (Fe3O4) as synergistic agents for NIR-induced PTT. In this study, phase-shift and NIR photoabsorbing poly(lactic-co-glycolic acid) (PLGA) nanocapsules (perfluorohexane (PFH)@PLGA/Fe3O4) were fabricated for MRI/US dual-modal imaging-guided PTT. The multifunctional nanocapsules can be used not only to increase the local tumor temperature by absorbing the NIR energy but also as bimodal contrast agents for both MRI and US imaging. Such nanocapsules can be converted into microbubbles under NIR irradiation, which produces excellent contrast for US imaging and enhanced cancer ablation. We refer to the nanocapsule phase transition process induced by the infrared lamp as NIR radiation droplet vaporization (NIRDV).
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Weixiang
authors.initials: W
authors.lastname: Song
authors.affiliation: ‡Department of Ultrasound, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Ran
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Ronghui
authors.initials: R
authors.lastname: Wang
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Yao
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Yuanyi
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: †Second Affiliated Hospital, Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, P.R. China.
authors.forename: Pan
authors.initials: P
authors.lastname: Li
mesh_terms: D045744:Cell Line, Tumor; D005466:Fluorocarbons / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D019344:Lactic Acid / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D057054:Molecular Imaging / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry*; D010789:Phototherapy / Q000379:methods*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014463:Ultrasonography
chemical_list: D005466:Fluorocarbons; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C078626:perflexane
keywords: near-infrared; phase-shift; photothermal therapy