title: Chronic airway obstruction after successful treatment of tuberculosis and its impact on quality of life.
abstract: METHODS
  Tuberculosis (TB) clinic in Tijuana, México.
  
  
  BACKGROUND
  Chronic airway obstruction (CAO) can be a sequella of pulmonary tuberculosis (PTB), independently of smoking history.
  
  
  OBJECTIVE
  To determine the prevalence of CAO in subjects recently recorded as cured after treatment of PTB, and its impact on quality of life.
  
  
  METHODS
  Cross-sectional study.
  
  
  RESULTS
  Overall, 34.3% of patients with a history of PTB had non-reversible CAO, defined as FEV1 <70% post-bronchodilator. Subjects with CAO had significantly more radiographic fibrocavitary sequellae on chest X-rays, more extensive changes (1.8 ± 0.8 affected quadrants vs. 1.3 ± 0.6, P = 0.04), more residual lung cavities (1.4 ± 0.8 vs. 0.5 ± 0.7, P = 0.002), and greater mediastinal retraction (42.4% vs. 16.7%, P = 0.026). The mean COPD Assessment Test score for subjects with CAO was 15.1 ± 10.4. The prevalence of irreversible CAO using the lower limit of normal criteria was higher (40%) than that calculated with fixed ratio criteria (34.3%).
  
  
  CONCLUSIONS
  Functional abnormalities are frequently already present at the end of treatment for PTB; patients with CAO are often symptomatic and experience a significant impact on quality of life.
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General Tijuana, Instituto de Servicios de Salud Pública, Tijuana, Mexico; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico.
authors.forename: I Laniado
authors.initials: IL
authors.lastname: de la Mora
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General Tijuana, Instituto de Servicios de Salud Pública, Tijuana, Mexico; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico.
authors.forename: D
authors.initials: D
authors.lastname: Martínez-Oceguera
authors.affiliation: Clínica y Laboratorio de Tuberculosis, Hospital General Tijuana, Instituto de Servicios de Salud Pública, Tijuana, Mexico; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana, Baja California, Mexico; Sistema Nacional de Investigadores, Consejo Nacional De Ciencia y Tecnología, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Laniado-Laborín
mesh_terms: D000328:Adult; D000554:Ambulatory Care Facilities; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000453:epidemiology; D011788:Quality of Life; D012129:Respiratory Function Tests; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000453:epidemiology*