title: The Role of Microvesicles Derived from Mesenchymal Stem Cells in Lung Diseases.
abstract: Microvesicles (MVs) are membrane vesicles that are released by many types of cells and have recently been considered important mediators of cell-to-cell communication. MVs serve as a vehicle to transfer proteins and messenger RNA and microRNA (miRNA) to distant cells, which alters the gene expression, proliferation, and differentiation of the recipient cells. Several studies have demonstrated that mesenchymal stem cells (MSCs) have the capacity to reverse acute and chronic lung injury in different experimental models through paracrine mechanisms. This paracrine action may be partially accounted for by MVs that are derived from MSCs. MSC-derived MVs may confer a stem cell-like phenotype to injured cells with the consequent activation of self-regenerative programmers. In this review, we summarize the characteristics and biological activities of MSC-derived MVs, and we describe their potential in novel therapeutic approaches in regenerative medicine to repair damaged tissues. Additionally, we provide an overview of studies that have assessed the role of MSC-derived MVs in lung diseases, including the mechanisms that may account for their therapeutic potential. Finally, we discuss the clinical use of MSC-derived MVs with several suggestions for enhancing their therapeutic efficiency.
authors.affiliation: Department of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Medical College, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, China ; Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, China.
authors.forename: Chonghui
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Medical College, Beijing, China.
authors.forename: Liangan
authors.initials: L
authors.lastname: Chen
mesh_terms: D002450:Cell Communication / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D006801:Humans; D008171:Lung Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D055370:Lung Injury / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D019899:Paracrine Communication / Q000235:genetics