title: Acanthosis nigricans: A fold (intertriginous) dermatosis.
abstract: Acanthosis nigricans (AN) is a mucocutaneous disorder that is characterized by focal or diffuse hyperkeratotic, surfaces, which are symmetrically distributed hyperpigmented lesions of the skin. It rarely affects mucosal surfaces like oral cavities. Although it is commonly seen in adolescents, AN is also increasingly seen in children who are obese. Recent studies have found that AN can be a cutaneous indicator of insulin resistance and malignancy. Acanthosis nigricans has been associated with type 2 diabetes mellitus, obesity, endocrinopathies, drugs, and malignancies.
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey. Electronic address: zekayikutlubay@hotmail.com.
authors.forename: Zekayi
authors.initials: Z
authors.lastname: Kutlubay
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Engin
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Orkhan
authors.initials: O
authors.lastname: Bairamov
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Tüzün
mesh_terms: D000052:Acanthosis Nigricans / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007333:Insulin Resistance; D007402:Intertrigo / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy