title: Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis.
abstract: Fractalkine (CX3C), a chemokine expressed by epithelial cells within normal and inflamed colorectal mucosa, induces leukocyte adhesion and migration via fractalkine receptor. The aim of this study was to investigate two single nucleotide polymorphisms of the fractalkine receptor gene as a risk factor both for the development and clinical findings of ulcerative colitis. In this study, 51 patients with ulcerative colitis (UC) and 80 controls were recruited. Genotypes of fractalkine receptorc.745G&gt;A (V249I) and c.839C&gt;T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p&gt;0.05). No statistically significant relationship was found between fractalkine receptor polymorphisms and clinical findings of UC. We observed no significant difference in fractalkine receptor polymorphism between patients and control group and no genotype-phenotype relation. Therefore, we concluded that fractalkine receptor polymorphisms may not contribute to the molecular pathogenesis of UC.
authors.affiliation: Ankara Yüksek İhtisas Research and Training Hospital, Department of gastroenterology. halesumer@yahoo.com.
authors.forename: Hale
authors.initials: H
authors.lastname: Gokcan
authors.forename: Erkan
authors.initials: E
authors.lastname: Yurtcu
authors.forename: Haldun
authors.initials: H
authors.lastname: Selcuk
authors.forename: Feride I
authors.initials: FI
authors.lastname: Sahin
mesh_terms: D000328:Adult; D000073883:CX3C Chemokine Receptor 1; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine