title: Recent advances in research of natural and synthetic bioactive quinolines.
abstract: Many natural products that consist of quinoline core are found to be bioactive and the versatility of quinoline and its derivatives have attracted great attention in the field of drug development. As a result, in recent years, many green and sustainable synthetic approaches for the synthesis of structurally diverse quinolines have been developed. This review covers four main aspects, namely bioactive quinoline alkaloids, the biological activity and mechanism of action of quinoline-based compounds as well as various quinoline syntheses.
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Po-Yee
authors.initials: PY
authors.lastname: Chung
authors.affiliation: Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Zhao-Xiang
authors.initials: ZX
authors.lastname: Bian
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Ho-Yuen
authors.initials: HY
authors.lastname: Pun
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Dessy
authors.initials: D
authors.lastname: Chan
authors.affiliation: Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Albert Sun-Chi
authors.initials: AS
authors.lastname: Chan
authors.affiliation: Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Johnny Cheuk-On
authors.initials: JC
authors.lastname: Tang
authors.affiliation: State Key Laboratory of Chirosciences, Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D011804:Quinolines