title: Occurrence of respiratory symptoms in persons with restrictive ventilatory impairment compared with persons with chronic obstructive pulmonary disease: The PLATINO study.
abstract: Patients with chronic obstructive pulmonary disease (COPD) usually complain of symptoms such as cough, sputum, wheezing, and dyspnea. Little is known about clinical symptoms in individuals with restrictive ventilatory impairment. The aim of this study was to compare the prevalence and type of respiratory symptoms in patients with COPD to those reported by individuals with restrictive ventilatory impairment in the Proyecto Latinoamericano de Investigacion en Obstruccion Pulmonar study. Between 2002 and 2004, individuals ≥40 years of age from five cities in Latin America performed pre and post-bronchodilator spirometry and had their respiratory symptoms recorded in a standardized questionnaire. Among the 5315 individuals evaluated, 260 (5.1%) had a restrictive spirometric diagnosis (forced vital capacity (FVC) < lower limit of normal (LLN) with forced expiratory volume in the first second to forced vital capacity ratio (FEV1/FVC) ≥ LLN; American Thoracic Society (ATS)/European Respiratory Society (ERS) 2005) and 610 (11.9%) were diagnosed with an obstructive pattern (FEV1/FVC < LLN; ATS/ERS 2005). Patients with mild restriction wheezed more ((30.8%) vs. (17.8%); p < 0.028). No difference was seen in dyspnea, cough, and sputum between the two groups after adjusting for severity stage. The health status scores for the short form 12 questionnaire were similar in restricted and obstructed patients for both physical (48.4 ± 9.4 vs. 48.3 ± 9.8) and mental (50.8 ± 10.6 vs. 50.0 ± 11.5) domains. Overall, respiratory symptoms are not frequently reported by patients with restricted and obstructed patterns as defined by spirometry. Wheezing was more frequent in patients with restricted pattern compared with those with obstructive ventilatory defect. However, the prevalence of cough, sputum production, and dyspnea are not different between the two groups when adjusted by the same severity stage.
authors.affiliation: Pulmonary Rehabilitation Center of Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil nivia.nonato@uol.com.br.
authors.forename: Nívia L
authors.initials: NL
authors.lastname: Nonato
authors.affiliation: Pulmonary Rehabilitation Center of Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Oliver A
authors.initials: OA
authors.lastname: Nascimento
authors.affiliation: Instituto Nacional de Enfermedades Respiratórias, México.
authors.forename: Rogelio P
authors.initials: RP
authors.lastname: Padilla
authors.affiliation: Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: Maria M
authors.initials: MM
authors.lastname: de Oca
authors.affiliation: Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: Carlos
authors.initials: C
authors.lastname: Tálamo
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Valdivia
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
authors.forename: Carmen
authors.initials: C
authors.lastname: Lisboa
authors.affiliation: Universidad de la República, Montevideo, Uruguay.
authors.forename: Maria V
authors.initials: MV
authors.lastname: López
authors.affiliation: Harvard University, Cambridge, MA, USA.
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Celli
authors.affiliation: Universidade Federal de Pelotas, Pelotas, Brazil.
authors.forename: Ana Maria B
authors.initials: AM
authors.lastname: Menezes
authors.affiliation: Pulmonary Rehabilitation Center of Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: José R
authors.initials: JR
authors.lastname: Jardim
mesh_terms: D000328:Adult; D000368:Aged; D003371:Cough / Q000453:epidemiology* / Q000209:etiology; D004417:Dyspnea / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005541:Forced Expiratory Volume; D006304:Health Status; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology*; D012135:Respiratory Sounds / Q000209:etiology; D013147:Spirometry; D013183:Sputum / Q000378:metabolism*; D011795:Surveys and Questionnaires; D014797:Vital Capacity
keywords: COPD; Restrictive; cough; dyspnea; respiratory symptoms