title: Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.
abstract: Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.
authors.affiliation: Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou, 11527, Athens, Greece, zcournia@bioacademy.gr.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Cournia
authors.forename: Toby W
authors.initials: TW
authors.lastname: Allen
authors.forename: Ioan
authors.initials: I
authors.lastname: Andricioaei
authors.forename: Bruno
authors.initials: B
authors.lastname: Antonny
authors.forename: Daniel
authors.initials: D
authors.lastname: Baum
authors.forename: Grace
authors.initials: G
authors.lastname: Brannigan
authors.forename: Nicolae-Viorel
authors.initials: NV
authors.lastname: Buchete
authors.forename: Jason T
authors.initials: JT
authors.lastname: Deckman
authors.forename: Lucie
authors.initials: L
authors.lastname: Delemotte
authors.forename: Coral
authors.initials: C
authors.lastname: Del Val
authors.forename: Ran
authors.initials: R
authors.lastname: Friedman
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Gkeka
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Hege
authors.forename: Jérôme
authors.initials: J
authors.lastname: Hénin
authors.forename: Marina A
authors.initials: MA
authors.lastname: Kasimova
authors.forename: Antonios
authors.initials: A
authors.lastname: Kolocouris
authors.forename: Michael L
authors.initials: ML
authors.lastname: Klein
authors.forename: Syma
authors.initials: S
authors.lastname: Khalid
authors.forename: M Joanne
authors.initials: MJ
authors.lastname: Lemieux
authors.forename: Norbert
authors.initials: N
authors.lastname: Lindow
authors.forename: Mahua
authors.initials: M
authors.lastname: Roy
authors.forename: Jana
authors.initials: J
authors.lastname: Selent
authors.forename: Mounir
authors.initials: M
authors.lastname: Tarek
authors.forename: Florentina
authors.initials: F
authors.lastname: Tofoleanu
authors.forename: Stefano
authors.initials: S
authors.lastname: Vanni
authors.forename: Sinisa
authors.initials: S
authors.lastname: Urban
authors.forename: David J
authors.initials: DJ
authors.lastname: Wales
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Smith
authors.forename: Ana-Nicoleta
authors.initials: AN
authors.lastname: Bondar
mesh_terms: D000818:Animals; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D026901:Membrane Transport Proteins