title: Histomorphometric Analysis of a Biopsy Harvested 10 Years After Maxillary Sinus Augmentation With Anorganic Bovine Bone Matrix and Plasma Rich in Growth Factors: A Case Report.
abstract: OBJECTIVE
  To evaluate the histologic and histomorphometric data 10 years after grafting of maxillary sinus in a case using anorganic bovine bone matrix (ABBM) and plasma rich in growth factors (PRGF).
  
  
  METHODS
  Histomorphometric measures were performed for newly formed bone, ABBM particles remnants, marrow spaces, and the presence of osteoblastic and osteoclastic activity.
  
  
  RESULTS
  Histologic analysis showed ABBM particles surrounded by new compact and mature vital bone. Osteocytes were noted within lacunae. Some osteoblastic and osteoclastic activity could be identified. The histomorphometric results were 21.7% of newly formed bone, 33.9% of ABBM, and 44% was composed of marrow spaces.
  
  
  CONCLUSIONS
  After 10 years postoperatively, the histologic evaluation of this case report demonstrated slow replacement of the ABBM particles by newly formed bone, even with the addition of PRGF. The residual ABBM particles were found in close contact to the newly formed bone.
authors.affiliation: *Former Resident, Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY; Periodontist and Oral Surgeon, Private Practice, Clínica Pardiñas, A Coruña, Spain. †Director of Clinical Research and Clinical Professor, Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY. ‡Assistant Clinical Professor, Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY; Associate Director of Periodontology & Implant Dentistry, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY.
authors.forename: Simón
authors.initials: S
authors.lastname: Pardiñas López
authors.forename: Stuart
authors.initials: S
authors.lastname: Froum
authors.forename: Ismael
authors.initials: I
authors.lastname: Khouly
mesh_terms: D000818:Animals; D001706:Biopsy; D001857:Bone Matrix / Q000637:transplantation*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D016348:Osseointegration / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology; D010518:Periodontitis / Q000473:pathology / Q000601:surgery*; D014183:Transplantation, Heterologous / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes