title: Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation.
abstract: The photo-generated closed-ring isomer of bis(5-methyl-2-phenylthiazoyl)perfluorocyclopentene shows cytotoxicity to Madin-Darby canine kidney (MDCK) cells through a caspase cascade and induces apoptosis of cells.
authors.affiliation: Department of Materials Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga 520-2194, Japan. uchida@rins.ryukoku.ac.jp.
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Okuda
authors.forename: Yukimi
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kodama
authors.forename: Kimio
authors.initials: K
authors.lastname: Sumaru
authors.forename: Kana
authors.initials: K
authors.lastname: Morishita
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kanamori
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamazoe
authors.forename: Kengo
authors.initials: K
authors.lastname: Hyodo
authors.forename: Shohei
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Miyatake
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokojima
authors.forename: Sinichiro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kingo
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D020169:Caspases / Q000378:metabolism*; D003517:Cyclopentanes / Q000737:chemistry* / Q000633:toxicity; D004285:Dogs; D005466:Fluorocarbons / Q000737:chemistry* / Q000633:toxicity; D007536:Isomerism; D061985:Madin Darby Canine Kidney Cells; D011108:Polymers / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D003517:Cyclopentanes; D005466:Fluorocarbons; D011108:Polymers; C521095:perfluorocyclopentene; D020169:Caspases