title: Characterizing Bile Acid and Lipid Metabolism in the Liver and Gastrointestinal Tract of Mice.
abstract: Mouse models that mimic human diseases are invaluable tools to study and discover genetic and pharmacological therapies for human diseases. The protocols described in this article are intended to assess general clinical parameters in the context of the enterohepatic system under both normal and pathological conditions. Methods are presented for characterizing liver and intestinal function with a focus on bile acid and lipid metabolism in the gut-liver axis. Curr. Protoc. Mouse Biol. 1:289-321 © 2011 by John Wiley & Sons, Inc.
authors.affiliation: Institute of Food, Nutrition, and Health, ETH Zurich, Schwerzenbach, Switzerland.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Modica
authors.affiliation: Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Murzilli
authors.affiliation: Laboratory of Lipid Metabolism and Cancer, Department of Translational Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.|Clinica Medica "A. Murri," Department of Internal and Public Medicine, University Aldo Moro of Bari, Bari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moschetta
keywords: bile acids; gut-liver axis; nuclear receptors