title: DNA damage and gene transcription: accident or necessity?
abstract: The extent to which DNA repair machinery facilitates gene activation remains poorly appreciated. A new study published in Cell Research reports a novel function of H2AX, a substrate of ATM and known DNA damage marker, in transcriptional initiation.
authors.affiliation: Center for Genomic Regulation (CRG), Dr Aiguader 88, E-08003, Barcelona, Spain; University Pompeu Fabra (UPF), E-08803, Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Beato
authors.affiliation: Center for Genomic Regulation (CRG), Dr Aiguader 88, E-08003, Barcelona, Spain; University Pompeu Fabra (UPF), E-08803, Barcelona, Spain.
authors.forename: Roni H
authors.initials: RH
authors.lastname: Wright
authors.affiliation: Center for Genomic Regulation (CRG), Dr Aiguader 88, E-08003, Barcelona, Spain; University Pompeu Fabra (UPF), E-08803, Barcelona, Spain.
authors.forename: Guillermo P
authors.initials: GP
authors.lastname: Vicent
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans
chemical_list: D006609:High Mobility Group Proteins; D006657:Histones