title: Elevated expression of HABP1 is correlated with metastasis and poor survival in breast cancer patients.
abstract: Hyaluronan-binding protein 1 (HABP1) is a protein with high affinity for HA, and has been reported to be upregulated in cancer cells. In this study, we show that silencing HABP1 inhibits proliferation, and suppresses the migration and invasion ability of breast cancer cell lines. In addition, silencing HABP1 remarkably slows down tumor growth in mice. We examined the correlation between HABP1 expression and clinicopathological parameters using immunohistochemistry in patients with breast cancer. The results indicate that HABP1 is overexpressed in cancer tissue, and its high levels are related to lymph node metastasis (P = 0.032) and tumor stage (P = 0.041). Moreover, high HABP1 expression is correlated with poor overall survival in breast cancer patients (P = 0.018), and is a signifi cant independent prognostic indicator. Our fi ndings suggest that HABP1 regulates proliferation and migration of breast cancer cells. HABP1 may be a useful independent predictor of outcomes in patients with breast cancer.
authors.affiliation: Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Niu
authors.affiliation: Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Yashuang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Da
authors.initials: D
authors.lastname: Pang
authors.affiliation: Department of Breast Surgery, The Affiliated Tumor Hospital of Harbin Medical University Harbin, Heilongjiang 150081, China.
authors.forename: Yanbo
authors.initials: Y
authors.lastname: Chen
keywords: HABP1; breast cancer; metastasis