title: Pathophysiological mechanisms of acute pancreatitis define inflammatory markers of clinical prognosis.
abstract: Development of acute pancreatitis illustrates the need to understand the basic mechanisms of disease progression to drive the exploration of therapeutic options. Cytokines play a major role in the pathogenesis of acute pancreatitis as underlying systemic inflammatory response, tissue damage, and organ dysfunction. However, little is known about circulating concentrations of these inflammatory markers and their real impact on clinical practice. Experimental studies have suggested that the prognosis for acute pancreatitis depends on the degree of pancreatic necrosis and the intensity of multisystem organ failure generated by the systemic inflammatory response. This suggests an intricate balance between localized tissue damage with proinflammatory cytokine production and a systemic anti-inflammatory response that restricts the inappropriate movement of proinflammatory agents into the circulation. Implication of such mediators suggests that interruption or blunting of an inappropriate immune response has the potential to improve outcome. A detailed understanding of pathophysiological processes and immunological aspects in patients with acute pancreatitis is the basis for the development of therapeutic strategies that will provide significant reductions in morbidity and mortality.
authors.affiliation: From the *Department of Surgery, University Hospital; and Departments of †Immunology and ‡Pathology, Trakia University, Stara Zagora, Bulgaria.
authors.forename: Georgi A
authors.initials: GA
authors.lastname: Minkov
authors.forename: Krasimira S
authors.initials: KS
authors.lastname: Halacheva
authors.forename: Yovcho P
authors.initials: YP
authors.lastname: Yovtchev
authors.forename: Maya V
authors.initials: MV
authors.lastname: Gulubova
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D010179:Pancreas / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators