title: The Use of Chemical-Chemical Interaction and Chemical Structure to Identify New Candidate Chemicals Related to Lung Cancer.
abstract: Lung cancer causes over one million deaths every year worldwide. However, prevention and treatment methods for this serious disease are limited. The identification of new chemicals related to lung cancer may aid in disease prevention and the design of more effective treatments. This study employed a weighted network, constructed using chemical-chemical interaction information, to identify new chemicals related to two types of lung cancer: non-small lung cancer and small-cell lung cancer. Then, a randomization test as well as chemical-chemical interaction and chemical structure information were utilized to make further selections. A final analysis of these new chemicals in the context of the current literature indicates that several chemicals are strongly linked to lung cancer.
authors.affiliation: College of Life Science, Shanghai University, Shanghai, 200444, People's Republic of China; College of Information Engineering, Shanghai Maritime University, Shanghai, 201306, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Shanghai, 201203, People's Republic of China.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.
authors.forename: Xiangyin
authors.initials: X
authors.lastname: Kong
authors.affiliation: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.affiliation: College of Life Science, Shanghai University, Shanghai, 200444, People's Republic of China.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Cai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001152:Arsenicals / Q000494:pharmacology; D001599:Berberine / Q000494:pharmacology; D063646:Carcinogenesis / Q000187:drug effects / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism; D003078:Colchicine / Q000494:pharmacology; D003630:Daunorubicin / Q000494:pharmacology; D004077:Digoxin / Q000494:pharmacology; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D011241:Prednisone / Q000494:pharmacology; D055752:Small Cell Lung Carcinoma / Q000188:drug therapy* / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D001599:Berberine; D014212:Tretinoin; D010042:Ouabain; D004077:Digoxin; C020300:monomethylarsonic acid; D003078:Colchicine; D011241:Prednisone; D003630:Daunorubicin