title: Study of Posterior Reversible Encephalopathy Syndrome in Children With Acute Lymphoblastic Leukemia After Induction Chemotherapy.
abstract: Increasing occurrence of posterior reversible encephalopathy syndrome has been reported in children with acute lymphoblastic leukemia. However, the etiology of posterior reversible encephalopathy syndrome is not clear. To study the possible pathogenetic mechanisms and treatment of this complication, we reported 11 cases of pediatric acute lymphoblastic leukemia who developed posterior reversible encephalopathy syndrome after induction chemotherapy. After appropriate treatment, the clinical symptoms of posterior reversible encephalopathy syndrome in most cases disappeared even though induction chemotherapy continued. During the 1-year follow-up, no recurrence of posterior reversible encephalopathy syndrome was observed. Although the clinical and imaging features of posterior reversible encephalopathy syndrome may be diverse, posterior reversible encephalopathy syndrome should be recognized as a possible important complication of acute lymphoblastic leukemia when neurologic symptoms appear. In line with previous reports, our study also indicated that posterior reversible encephalopathy syndrome was reversible when diagnosed and treated at an early stage. Thus, the occurrence of posterior reversible encephalopathy syndrome should be considered and investigated to optimize the early induction scheme of acute lymphoblastic leukemia treatment.
authors.affiliation: Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Tang
authors.affiliation: Department of Internal Medicine, Children's Hospital Affiliated to Soochow University, Suzhou, China jianmei0512@163.com.
authors.forename: Jian-Mei
authors.initials: JM
authors.lastname: Tian
authors.affiliation: Radiology Department, Children's Hospital Affiliated to Soochow University, Suzhou, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Sheng
authors.affiliation: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: Shao-Yan
authors.initials: SY
authors.lastname: Hu
authors.affiliation: Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China.
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Radiology Department, Children's Hospital Affiliated to Soochow University, Suzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D060828:Induction Chemotherapy / Q000009:adverse effects* / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D054038:Posterior Leukoencephalopathy Syndrome / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: acute lymphoblastic leukemia; childhood; induction chemotherapy; magnetic resonance imaging (MRI); posterior reversible encephalopathy syndrome