title: Synthesis of N-Vinyl Nitrones via 1,4-Conjugate Elimination.
abstract: A number of structurally and electronically diverse N-vinyl nitrones have been synthesized by a two-step method. The sequence consists of condensation of an α-chloroaldehyde or an α-phenoxy- or α-acetoxy ketone with a substituted benzyl hydroxylamine to provide the corresponding nitrone. Treatment of these species with a base induces a 1,4-elimination to provide the desired N-vinyl nitrone in good to excellent yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Michael
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States.
authors.forename: Katelyn M
authors.initials: KM
authors.lastname: Chando
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309, United States.
authors.forename: Tarek
authors.initials: T
authors.lastname: Sammakia