title: Renal involvement in idiopathic hypereosinophic syndrome.
abstract: The hypereosinophilic syndromes (HESs) are a group of disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. In idiopathic HES, the underlying cause of hypereosinophilia (HE) remains unknown despite thorough aetiological work-up. Kidney disease is thought to be rare in HES. Renal manifestations described include eosinophilic interstitial nephritis, various types of glomerulopathies, thrombotic microangiopathy (TMA) and electrolyte disturbances. The diagnosis must be made in time, because a recovery of renal function can be obtained if treatment is initiated promptly.
authors.affiliation: Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Shehwaro
authors.affiliation: Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
authors.forename: Anne Lyse
authors.initials: AL
authors.lastname: Langlois
authors.affiliation: Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
authors.forename: Victor
authors.initials: V
authors.lastname: Gueutin
authors.affiliation: Department of Nephrology , Pitie Salpetriere Hospital , Paris , France.
authors.forename: Hassane
authors.initials: H
authors.lastname: Izzedine
keywords: eosinophil; glomerulopathy; hypercalcaemia; thrombotic microangiopathy