title: Open Lung Biopsy Among Critically Ill, Mechanically Ventilated Patients. A Metaanalysis.
abstract: BACKGROUND
  Open lung biopsy may be performed to guide therapy in mechanically ventilated patients with diagnostic uncertainty regarding etiology of pulmonary infiltrates. Current evidence for open lung biopsy in mechanically ventilated patients comes from single-center case series.
  
  
  OBJECTIVE
  We performed a metaanalysis of case series to determine diagnoses, complications, and changes in therapy after lung biopsy in critically ill patients requiring mechanical ventilation.
  
  
  METHODS
  We searched Medline for case series of lung biopsies in critically ill patients requiring mechanical ventilation. We pooled results of individual case series using random effects metaanalysis models to obtain summary proportions.
  
  
  RESULTS
  We identified 14 case series including a total of 512 mechanically ventilated patients with 530 histopathological diagnoses. The most common diagnoses were "fibrosis/pneumonitis" (n = 155, 25%; 95% confidence interval [CI], 14-37%) and infection (n = 113, 20%; 95% CI, 15-27%). Viruses were the most commonly identified infectious etiology identified on open lung biopsy, representing 50% of potential pathogens. Diffuse alveolar damage was present in a minority of specimens (n = 100, 16%; 95% CI, 8-25%). Therapeutic changes after lung biopsy occurred in 399 patients (78%; 95% CI, 64-81%). Procedure-related complications occurred in 29% of patients (95% CI, 25-33%), most commonly persistent air leak. Mortality among mechanically ventilated patients after diagnostic open lung biopsy was 54%.
  
  
  CONCLUSIONS
  Among mechanically ventilated patients with respiratory failure of unclear etiology, lung biopsy yielded a wide range of diagnoses and was associated with a change in therapy in most patients.
authors.affiliation: 1 Department of Internal Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts; and.
authors.forename: Alexandra K
authors.initials: AK
authors.lastname: Wong
authors.affiliation: 2 Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts.
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Walkey
mesh_terms: D001706:Biopsy; D016638:Critical Illness / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000601:surgery*; D012121:Respiration, Artificial / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology*
keywords: acute respiratory distress syndrome; biopsy; diffuse pulmonary infiltrate; humans; respiratory failure