title: New and efficient approach for synthesis of novel bioactive [1,3,4]thiadiazoles incorporated with 1,3-thiazole moiety.
abstract: A series of novel 1,3,4-thiadiazoles incorporated with thiazole moiety was synthesized by reaction of 5-acetyl-2-benzoylimino-3-phenyl-1,3,4-thiadiazole thiosemicarbazone 2 with each of N-phenyl 2-oxo-propanehydrazonoyl chloride 3 and ethyl (N-aryl-hydrazono) chloroacetate 5 in dioxane in basic medium. Also, another series of 1,3,4-thiadiazole incorporated with thiazole moiety was prepared by reaction of 5-acetyl-2-benzoylimino-3-phenyl-1,3,4-thiadiazole thiocarbohydrazone with each of hydrazonoyl chlorides 3, 5 and 18 under the same reaction conditions. The mechanisms of the studied reactions were discussed and the assigned structure for each of the new products was identified via elemental and spectral data and by alternative method whenever possible. Moreover, the antimicrobial activity for some selected products was screened, and the results obtained exploring the high potency of some of the tested compounds compared with the employed standard bactericides and fungicide.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia. Electronic address: thoraya-f@hotmail.com.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
authors.forename: Magda A
authors.initials: MA
authors.lastname: Abdallah
authors.affiliation: Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukkarramah, Saudi Arabia.
authors.forename: Ghada S
authors.initials: GS
authors.lastname: Masaret
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt.
authors.forename: Zeinab A
authors.initials: ZA
authors.lastname: Muhammad
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D013830:Thiadiazoles; D013844:Thiazoles; C058949:1,3,4-thiadiazole
keywords: 1,3,4-thiadiazole; Antimicrobial activity; Carbonothioic dihydrazide; Hydrazonoyl chlorides; Thiazoles