title: Sleep in Autism Spectrum Disorders.
abstract: Autism spectrum disorders (ASD) are common neurodevelopmental conditions, affecting 1 in 68 children. Sleep disturbance, particularly insomnia, is very common in children diagnosed with ASD, with evidence supporting overlapping neurobiological and genetic underpinnings. Disturbed sleep exacerbates core and related ASD symptoms and has a substantial negative impact on the entire family. Treatment of sleep disturbance holds promise for ameliorating many of the challenging behavioral symptoms that children with ASD and their families face. Behavioral and pharmacological studies indicate promising approaches to treating sleep disturbances in this population. Awareness of treatment options is particularly important as parents and clinicians may believe that sleep disturbance is part of autism and refractory to therapy. In addition, autism symptoms refractory to treatment with conventional psychiatric medications may improve when sleep is addressed. Additional evidence-based studies are needed, including those that address the underlying biology of this condition.
authors.affiliation: Sleep Disorders Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Olivia J
authors.initials: OJ
authors.lastname: Veatch
authors.affiliation: Department of Developmental Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Angela C
authors.initials: AC
authors.lastname: Maxwell-Horn
authors.affiliation: Sleep Disorders Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Beth A
authors.initials: BA
authors.lastname: Malow
keywords: Autism; Behavioral Therapy; Biochemistry; Diagnosis; Genetics; Neurodevelopmental Disorders; Pediatric Sleep Disorders; Pharmacotherapy