title: An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes.
abstract: An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes was developed. The transformation employs only AgSCF3 and KI in situ generated active nucleophilic trifluoromethylthio species and cleanly occurs in up to quantitative yield at room temperature, thereby providing an unprecedentedly easy entry to various α-SCF3-substituted ketones/arylmethanes.
authors.affiliation: Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 20025, P.R. China. lfdeng@msn.com.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
authors.forename: Fangxia
authors.initials: F
authors.lastname: Zhu
authors.forename: Haoyue
authors.initials: H
authors.lastname: Xiang
authors.forename: Xing
authors.initials: X
authors.lastname: Xu
authors.forename: Lianfu
authors.initials: L
authors.lastname: Deng
authors.forename: Chunhao
authors.initials: C
authors.lastname: Yang
mesh_terms: D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008697:Methane / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D013438:Sulfhydryl Compounds; D008697:Methane