title: Quantitative CT assessment of bone mineral density in dogs with hyperadrenocorticism.
abstract: Canine hyperadrenocorticism (HAC) is one of the most common causes of general osteopenia. In this study, quantitative computed tomography (QCT) was used to compare the bone mineral densities (BMD) between 39 normal dogs and 8 dogs with HAC (6 pituitary-dependent hyperadrenocorticism [PDH]; pituitary dependent hyperadrenocorticism, 2 adrenal hyperadrenocorticism [ADH]; adrenal dependent hyperadrenocorticism) diagnosed through hormonal assay. A computed tomogaraphy scan of the 12th thoracic to 7th lumbar vertebra was performed and the region of interest was drawn in each trabecular and cortical bone. Mean Hounsfield unit values were converted to equivalent BMD with bone-density phantom by linear regression analysis. The converted mean trabecular BMDs were significantly lower than those of normal dogs. ADH dogs showed significantly lower BMDs at cortical bone than normal dogs. Mean trabecular BMDs of dogs with PDH using QCT were significantly lower than those of normal dogs, and both mean trabecular and cortical BMDs in dogs with ADH were significantly lower than those of normal dogs. Taken together, these findings indicate that QCT is useful to assess BMD in dogs with HAC.
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Donghoon
authors.initials: D
authors.lastname: Lee
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Youngjae
authors.initials: Y
authors.lastname: Lee
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Wooshin
authors.initials: W
authors.lastname: Choi
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Jinhwa
authors.initials: J
authors.lastname: Chang
authors.affiliation: Laboratories of Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Ji-Houn
authors.initials: JH
authors.lastname: Kang
authors.affiliation: Laboratories of Clinical Pathology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Ki-Jeong
authors.initials: KJ
authors.lastname: Na
authors.affiliation: Department of Medical Imaging, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea.
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Chang
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D015519:Bone Density; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004285:Dogs / Q000502:physiology; D005260:Female; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D012016:Reference Values; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000662:veterinary*
keywords: bone mineral density; dog; hyperadrenocorticism; quantitative computed tomography