title: High-Throughput and Rapid Screening of Low-Mass Hazardous Compounds in Complex Samples.
abstract: Rapid screening and identification of hazardous chemicals in complex samples is of extreme importance for public safety and environmental health studies. In this work, we report a new method for high-throughput, sensitive, and rapid screening of low-mass hazardous compounds in complex media without complicated sample preparation procedures. This method is achieved based on size-selective enrichment on ordered mesoporous carbon followed by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis with graphene as a matrix. The ordered mesoporous carbon CMK-8 can exclude interferences from large molecules in complex samples (e.g., human serum, urine, and environmental water samples) and efficiently enrich a wide variety of low-mass hazardous compounds. The method can work at very low concentrations down to part per trillion (ppt) levels, and it is much faster and more facile than conventional methods. It was successfully applied to rapidly screen and identify unknown toxic substances such as perfluorochemicals in human serum samples from athletes and workers. Therefore, this method not only can sensitively detect target compounds but also can identify unknown hazardous compounds in complex media.
authors.affiliation: †State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.|‡Department of Chemistry, Fuzhou University, Fuzhou 350002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: †State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: †State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: †State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: ‡Department of Chemistry, Fuzhou University, Fuzhou 350002, China.
authors.forename: Liangqia
authors.initials: L
authors.lastname: Guo
authors.affiliation: †State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
mesh_terms: D015386:Hazardous Substances / Q000032:analysis*; D057166:High-Throughput Screening Assays / Q000379:methods*; D057230:Limit of Detection; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D015386:Hazardous Substances