title: [Simvastatin's effect on insulin resistance in rats with diabetes mellitus].
abstract: The aim of this experimental study was to estimate the effect of Simvastatin on glycemic variability-related insulin resistance in the course of diabetes mellitus (DM) in rats. Fifty seven male Wistar rats were divided into four groups: I - rats with diabetes mellitus and glycemic variability treated with Simvastatin (20 mg/kg body weight, intragastral during 8 weeks); II - placebo-treated rats with DM and glycemic variability; III - placebo treated rats with DM and IV - nondiabetic control rats. DM was induced by feeding rats with high-fat diet (61%) during five weeks and low-dose of Streptozotocin (30 mg/kg, intraperitoneally). Daily glucose excursions were stimulated by feeding animals twice a day. We measured fasting blood glucose, glycated hemoglobin (HbA1c), insulin and HOMAIR was calculated. Higher insulin resistance in diabetic rats is related to greater daily glycemic variability. In our study was installed significant increasing HOMAIR in diabetics rats with glycemic excursions comparison with the control. Our results showed that the simvastatin-treatment decreases the indices glycemic variability and HOMA in diabetic rats with glycemic excursions.
authors.affiliation: West Kazakhstan State Medical University, Aktobe, Kazakhstan; Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: S
authors.initials: S
authors.lastname: Iskakova
authors.affiliation: West Kazakhstan State Medical University, Aktobe, Kazakhstan; Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Zharmakhanova
authors.affiliation: West Kazakhstan State Medical University, Aktobe, Kazakhstan; Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Y
authors.initials: Y
authors.lastname: Bekmukhambetov
authors.affiliation: West Kazakhstan State Medical University, Aktobe, Kazakhstan; Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Dworacka
authors.affiliation: West Kazakhstan State Medical University, Aktobe, Kazakhstan; Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Dworacki
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D051381:Rats; D019821:Simvastatin / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019821:Simvastatin