title: [Hypertension and cardiovascular risk associated with obstructive sleep apnea in adult in Guadeloupe (French West Indies)].
abstract: OBJECTIVE
  In Guadeloupe, data on the relationships between arterial hypertension and obstructive sleep apnea are unavailable. The aim of this study was: to assess the frequency of hypertension and non-dipper pattern evaluated by 48-hour ambulatory blood pressure monitoring in an adult population identified obstructive sleep apnea/non-obstructive sleep apnea during overnight polygraphy ; to determine the cardio-metabolic factors associated with obstructive sleep apnea.
  
  
  METHODS
  A cross-sectional study was realized at Pointe-à-Pitre Hospital. Patients were referred for suspected sleep apnea to sleep specialist and performed a nocturnal polygraphy. Diagnosis was confirmed if the apnea-hypopnea index was ≥ 5. We obtained two groups: sleep apnea/non-sleep apnea. All patients underwent 48-hour ambulatory blood pressure monitoring. The cardio-metabolic factors were identified and assessed (fasten level of hs-CRP and Homa-IR index).
  
  
  RESULTS
  A total of 204 patients were included. Mean age at diagnosis was 54 ± 10 years, 63% were women. OSA was present in 69.6% with a higher frequency in men than in women. Difference was not significant between the two groups for hypertension frequency (84.5% vs 77%; P=0.22), non-dipper pattern (77.5% vs 76%; P=0.79) and hs-CRP. Differences for age, snoring, body max index, mean waist circumference, Homa-IR index, obesity, dyslipidemia, and type 2 diabetes were significant.
  
  
  CONCLUSIONS
  Our data highlight raised frequency of cardiovascular metabolic factors in patients with obstructive sleep apnea and confirm their high cardiovascular risk.
authors.affiliation: Unité d'explorations cardiovasculaires, pôle cardiovasculaire, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe. Electronic address: rachel.brissac@chu-guadeloupe.fr.
authors.forename: R
authors.initials: R
authors.lastname: Billy Brissac
authors.affiliation: Laboratoire du sommeil, 97139 Les Abymes, Guadeloupe.
authors.forename: S
authors.initials: S
authors.lastname: Phiraï
authors.affiliation: Service de cardiologie, pôle cardiovasculaire, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
authors.forename: L
authors.initials: L
authors.lastname: Larifla
authors.affiliation: Service de cardiologie, pôle vasculaire, centre hospitalier de Basse-Terre, 97100 Basse-Terre, Guadeloupe.
authors.forename: A
authors.initials: A
authors.lastname: Atallah
authors.affiliation: Service de cardiologie, pôle cardiovasculaire, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
authors.forename: M
authors.initials: M
authors.lastname: Hedreville
authors.affiliation: Service de cardiologie, pôle vasculaire, centre hospitalier de Basse-Terre, 97100 Basse-Terre, Guadeloupe.
authors.forename: S
authors.initials: S
authors.lastname: Hedreville
authors.affiliation: Laboratoire du sommeil, 97100 Basse-Terre, Guadeloupe.
authors.forename: M
authors.initials: M
authors.lastname: Fassih
authors.affiliation: Service de pneumologie, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
authors.forename: G
authors.initials: G
authors.lastname: Cadelis
authors.affiliation: Cabinet de médecine générale, 97111 Morne-à-l'eau, Guadeloupe.
authors.forename: P
authors.initials: P
authors.lastname: Rhinan
authors.affiliation: Direction de la recherche clinique, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
authors.forename: V
authors.initials: V
authors.lastname: Hamony Soter
authors.affiliation: Direction de la recherche clinique, CHU de Pointe-à-Pitre, BP 465, 97159 Pointe-à-Pitre cedex, Guadeloupe.
authors.forename: L
authors.initials: L
authors.lastname: Foucan
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D019430:Guadeloupe / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications*
keywords: 48-hour ambulatory blood pressure monitoring; Apnée obstructive du sommeil; Arterial hypertension; Cardiovascular risk; Facteur; Factor; Frequency; Fréquence; Hypertension artérielle; Mesure ambulatoire pression artérielle 48heures; Obstructive sleep apnea; Polygraphie; Polygraphy; Risque cardiovasculaire