title: Spontaneous Regression of Pulmonary Lymphoepithelioma-Like Carcinoma.
abstract: The spontaneous regression of lung cancer is extremely rare. We encountered a case of a 70-year-old man with pulmonary lymphoepithelioma-like carcinoma that regressed without receiving anticancer therapy. The patient had depression during tumor regression, however, and was treated with a serotonin-selective reuptake inhibitor. On histologic examination, CD3(+), CD4(+), and CD8(+) lymphocytes were found to have infiltrated around the tumor. Thus, the serotonin-selective reuptake inhibitor may have activated these lymphocytes to cause spontaneous tumor regression.
authors.affiliation: Division of General Thoracic Surgery, Kohka Public Hospital, Shiga, Japan. Electronic address: kawaguchi1228@yahoo.co.jp.
authors.forename: Yo
authors.initials: Y
authors.lastname: Kawaguchi
authors.affiliation: Division of General Thoracic Surgery, Kohka Public Hospital, Shiga, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Fujita
authors.affiliation: Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Shiga, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Hanaoka
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000175:diagnosis*; D000368:Aged; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D014057:Tomography, X-Ray Computed