title: Two new phenylpropanoids and one new sesquiterpenoid from the bioactive fraction of Sambucus williamsii.
abstract: Two new phenylpropanoids, samwirin (1) and samwiphenol (2), and a new sesquiterpenoid, 2β,4β,10α-trihydroxy-1αH,5βH-guaia-6-ene (3), together with six known compounds were isolated from the bioactive fraction of Sambucus williamsii Hance. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D-NMR, MS, and CD spectral data. In vitro proliferation effects of all compounds on osteoblast-like UMR 106 cells were examined. Compounds 1, 4-9 significantly promoted cell proliferation. Compounds 5, 6, and 8 increased osteoblastic cell numbers separately by 24.3%, 25.2%, and 29.1% at 10(-10) M, 10(-10) M, and 10(-8) M, respectively.
authors.affiliation: a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Xiao
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Man-Sau
authors.initials: MS
authors.lastname: Wong
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010006:Osteoblasts / Q000187:drug effects; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027923:Sambucus / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000602118:2beta,4beta,10alpha-trihydroxy-1alphaH,5betaH-guaia-6-ene; D010666:Phenylpropionates; D012717:Sesquiterpenes; C000602116:samwiphenol; C000602115:samwirin
keywords: Caprifoliaceae; Sambucus williamsii; UMR 106 cells; phenylpropanoid; proliferation effects; sesquiterpenoid