title: Characterization of novel composite alginate chitosan-carrageenan nanoparticles for encapsulation of BSA as a model drug delivery system.
abstract: The objective of this research project was to develop a nanoparticle drug delivery system using the biopolymer chitosan as the base component. The nanoparticles were produced through ionotropic gelation by flush mixing chitosan with counterions carrageenan and alginate. The nanoparticles were generated under a range of conditions to determine the effect of pH, chitosan concentration, carrageenan concentration, and alginate concentration on the nanoparticle characteristics of particle diameter, zeta potential, and particle size distribution. The encapsulation and controlled release of BSA from chitosan nanoparticles was also evaluated. The encapsulation of BSA was used as a model system for the controlled drug delivery from composite nanoparticles. The release profile indicated an initial burst in the first few hours of the trial, followed by a slower steady release over time. According to Korsmeyer-Peppas model, the release profile followed fickian diffusion.
authors.forename: Landi
authors.initials: L
authors.lastname: Cheng
authors.forename: Cody
authors.initials: C
authors.lastname: Bulmer
authors.affiliation: Department of Chemical and Biochemical Engineering, the University of Western Ontario, London, Ontario, N6A 5B9, Canada. amarg@uwo.ca.
authors.forename: Argyrios
authors.initials: A
authors.lastname: Margaritis
mesh_terms: D000464:Alginates / Q000737:chemistry; D002351:Carrageenan / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D048271:Chitosan / Q000737:chemistry; D003692:Delayed-Action Preparations; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles; D010316:Particle Size; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D012710:Serum Albumin, Bovine; D020723:Glucuronic Acid; D002351:Carrageenan; D048271:Chitosan