title: Nasal manifestations of IgG4-related disease: A report of two cases.
abstract: IgG4-related disease (IgG4-RD) is a recently recognized clinical disease entity characterized by elevated serum IgG4, tumefaction, tissue infiltration of IgG4-positive plasma cells and fibrosis. IgG4-RD may occur, either synchronously or metachronously, in a variety of organs throughout the body. We describe herein two representative cases of the nasal manifestations of IgG4-RD, characterized by diffuse, crusty, erosive lesions on nasal mucosa. Oral steroid administration was effective in treating these nasal manifestations. We report a decrease in IgG4 positive plasma cell infiltrates in nasal mucosa biopsy specimens after steroid therapy, demonstrating that infiltration of IgG4-positive cells is reversible.
authors.affiliation: Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Japan. Electronic address: takoto@tmd.ac.jp.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohno
authors.affiliation: Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Arai
authors.affiliation: Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: Yurika
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology* / Q000473:pathology; D012220:Rhinitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012852:Sinusitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G
keywords: IgG4; IgG4-related disease; Immunoglobulin; Nasal manifestations; Rhinitis; Rhinosinusitis