title: Association between Cerebral Palsy or Death and Umbilical Cord Blood Magnesium Concentration.
abstract: OBJECTIVE
  This study aims to evaluate whether magnesium sulfate (MgSO4) infusion at the time of delivery or magnesium cord blood concentration is associated with cerebral palsy (CP) or death diagnosed by the age of 2 years.
  
  
  METHODS
  Secondary analysis of data from a randomized trial of MgSO4 versus placebo for prevention of CP or death among offspring of women with anticipated preterm delivery. This study cohort included singleton, nonanomalous fetuses, whose mothers received MgSO4 as neuroprophylaxis. The primary outcomes were CP or death diagnosed by the age of 2 years.
  
  
  RESULTS
  A total of 936 neonates (93 with CP or death, 843 controls) were included in the analysis. Infants in the group with CP or death had MgSO4 infusing at delivery at a similar frequency to that of controls (49 [52.7%] vs. 463 [54.9%], p = 0.68). Mean concentrations of cord blood magnesium, available for 596 neonates, also were not different between the two groups (2.7 ± 0.9 vs. 2.6 ± 0.9 mEq/L, p = 0.66, respectively). Multivariable analyses did not alter these findings.
  
  
  CONCLUSIONS
  Among the offspring of women exposed to MgSO4, in utero, neither MgSO4 infusion at the time of delivery nor magnesium cord blood concentration is associated with CP or death.
authors.affiliation: Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: Anna
authors.initials: A
authors.lastname: Palatnik
authors.affiliation: Department of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
authors.forename: Dwight J
authors.initials: DJ
authors.lastname: Rouse
authors.affiliation: Department of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors.forename: David M
authors.initials: DM
authors.lastname: Stamilio
authors.affiliation: Department of Obstetrics and Gynecology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: McPherson
authors.affiliation: Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
authors.forename: William A
authors.initials: WA
authors.lastname: Grobman
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008274:Magnesium / Q000097:blood*; D008278:Magnesium Sulfate / Q000627:therapeutic use; D008297:Male; D018743:Perinatal Care; D011247:Pregnancy; D055815:Young Adult
chemical_list: D008278:Magnesium Sulfate; D008274:Magnesium