title: Candida albicans chronic colonisation in cystic fibrosis may be associated with inhaled antibiotics.
abstract: Candida albicans is increasingly recognised as a coloniser of the respiratory tract in cystic fibrosis (CF) patients. Yet, the potential role, if any, of the micro-organism in the progress of the disease remains unclear. In this study, we investigated the association between inhaled antibiotics and C. albicans chronic colonisation in patients with CF. A cohort of 121 CF patients born from 1988 to 1996 was, respectively, studied. The medical records of each patient were reviewed from the first time they attended the CF Centre until the occurrence of C. albicans chronic colonisation or their last visit for the year 2010. Chronic colonisation was defined as the presence of C. albicans in more than 50% of cultures in a given year. A number of possible confounders were included in the multivariate logistic regression analysis to identify an independent association between inhaled antibiotics and C. albicans chronic colonisation. Fifty-four (44.6%) of the 121 patients enrolled in the study developed chronic colonisation by the micro-organism. Multivariate logistic regression analysis determined the independent effect of inhaled antibiotic treatment on the odds of chronic colonisation (OR 1.112, 95% CI [1.007-1.229], P = 0.036). Candida albicans chronic colonisation may be associated with the duration of inhaled antibiotic treatment.
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Noni
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Katelari
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.|Pulmonology Unit, 1st Department of Pediatrics, Medical School, University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Kaditis
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Theochari
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Ioulia
authors.initials: I
authors.lastname: Lympari
authors.affiliation: Department of Microbiology, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Helen
authors.initials: H
authors.lastname: Alexandrou-Athanassoulis
authors.affiliation: Department of Cystic Fibrosis, "Aghia Sophia" Children's Hospital, Athens, Greece.
authors.forename: Stavros-Eleftherios
authors.initials: SE
authors.lastname: Doudounakis
authors.affiliation: Department of Critical Care, Medical School, University of Athens, University Hospital "Attikon", Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Dimopoulos
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002176:Candida albicans / Q000254:growth & development*; D002648:Child; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D055991:Health Records, Personal; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D012137:Respiratory System / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents
keywords: Candida albicans; Cystic fibrosis; colonisation; inhaled antibiotics; yeast