title: Cinnarizine: Comprehensive Profile.
abstract: Cinnarizine is a piperazine derivative with antihistaminic, antiserotonergic, antidopaminergic, and calcium channel-blocking activities. A comprehensive profile was performed on cinnarizine including its description and the different methods of analysis. The 1H NMR and 13C one- and two-dimensional NMR methods were used. In addition, infrared and mass spectral analyses were performed which all confirmed the structure of cinnarizine.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: nharess@ksu.edu.sa.
authors.forename: Nadia G
authors.initials: NG
authors.lastname: Haress
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D002936:Cinnarizine / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000737:chemistry; D004355:Drug Stability; D006634:Histamine H1 Antagonists / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D018377:Neurotransmitter Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D002121:Calcium Channel Blockers; D018492:Dopamine Antagonists; D006634:Histamine H1 Antagonists; D018377:Neurotransmitter Agents; D012702:Serotonin Antagonists; D002936:Cinnarizine
keywords: Antihistaminic; Cinnarizine; Metabolism; Pharmacokinetics; Pharmacology; Spectroscopy