title: Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.
abstract: OBJECTIVE
  Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was to clarify the expression of ZNF703 protein and its prognostic effect on HNSCC.
  
  
  METHODS
  Two hundred ten HNSCC patients from Sun Yat-Sen University Cancer Center with complete survival follow-up were included in this study. Tumor samples from primary sites were collected. The expression of the ZNF703 protein was tested by immunohistochemistry (IHC).
  
  
  RESULTS
  The high expression of ZNF703 in HNSCC tumor tissues was significantly higher than that of the matched noncancerous tissues (48.6% versus 11.6%, P < 0.001). ZNF703 overexpression was correlated with tumor position (laryngeal carcinoma) and recurrence (all P < 0.05). Multivariate analysis revealed that ZNF703 protein overexpression was an independent prognostic factor (P = 0.022, hazard ratio = 1.635, 95% CI 1.073-2.493) in HNSCC patients.
  
  
  CONCLUSIONS
  ZNF703 overexpression is associated with adverse prognosis in HNSCC, which might be a novel biomarker of HNSCC.
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yang
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Jiang
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Clinical Trial Center, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Neurology, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yong-An
authors.initials: YA
authors.lastname: Sun
authors.affiliation: Department of Medical Oncology, Guangxi Traditional Chinese Medical University, Ruikang Hospital, Nanning 530011, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Xin
authors.initials: X
authors.lastname: An
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Zhang
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Song
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Wang
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Zhong-Yu
authors.initials: ZY
authors.lastname: Yuan
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Rou-Jun
authors.initials: RJ
authors.lastname: Peng
authors.affiliation: Department of Oncology, Huizhou Municipal Central Hospital, Huizhou 516001, China.
authors.forename: Tan-Huan
authors.initials: TH
authors.lastname: Chen
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Colorectal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Li-Ren
authors.initials: LR
authors.lastname: Li
authors.affiliation: Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China ; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D011379:Prognosis; D016019:Survival Analysis; D015854:Up-Regulation
chemical_list: D002352:Carrier Proteins; C541016:ZNF703 protein, human