title: Seroprevalence of past dengue virus infection among children and adolescents in Singapore.
abstract: We conducted a pediatric seroprevalence study of dengue virus (DENV) infection in Singapore, a dengue endemic city-state. Residual sera from 1,200 Singapore residents aged 1-17 years seen in two hospitals between 2008 and 2010 were tested for anti-DENV IgG antibodies. The overall seroprevalence was 10.4% (95%CI: 8.7-12.1%). There had been a marked decline in seroprevalence in the 15-19-year age group over the last three decades, while the prevalence in the 1-5-year olds (12.6%) was significantly higher than that of the 1996-1997 pediatric survey (0.8%). The overall dengue seroprevalence in children and adolescents remained low.
authors.affiliation: Epidemiology & Disease Control Division, Ministry of Health, Singapore.
authors.forename: Li Wei
authors.initials: LW
authors.lastname: Ang
authors.affiliation: Communicable Diseases Division, Ministry of Health, Singapore.
authors.forename: Jeffery
authors.initials: J
authors.lastname: Cutter
authors.affiliation: Epidemiology & Disease Control Division, Ministry of Health, Singapore.
authors.forename: Lyn
authors.initials: L
authors.lastname: James
authors.affiliation: Communicable Diseases Division, Ministry of Health, Singapore.|Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
authors.forename: Kee Tai
authors.initials: KT
authors.lastname: Goh
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D016036:Seroepidemiologic Studies; D012846:Singapore / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
keywords: dengue; epidemics; pediatric; seroprevalence