title: HELICOBACTER PYLORI PREVALENCE IN PATIENTS WITH CELIAC DISEASE: results from a cross-sectional study.
abstract: BACKGROUND
  Some previously published studies have suggested an inverse relationship between celiac disease and Helicobacter pylori, raising the possibility of the protective role Helicobacter pylori could have against celiac disease development. Nevertheless, this association is inconclusive.
  
  
  OBJECTIVE
  To determine the prevalence of Helicobacter pylori infection in celiac subjects.
  
  
  METHODS
  Between January 2013 and June 2014, patients over 18 years old undergoing upper endoscopy who required both gastric and duodenal biopsies were included for analysis. Enrolled subjects were divided in two groups: those with a diagnosis of celiac disease and those without a celiac disease diagnosis. Helicobacter pylori infection prevalence was compared between groups. Among celiac patients, endoscopic markers of villous atrophy as well as histological damage severity were compared between those with and without Helicobacter pylori infection.
  
  
  RESULTS
  Overall, 312 patients were enrolled. Seventy two of them had a diagnosis of celiac disease. Helicobacter pylori infection prevalence among celiac disease patients was 12.5%, compared to 30% in non-celiac patients [OR=0.33 (0.15-0.71)]. There was not a significant difference in terms of the severity of villous atrophy in patients with Helicobacter pylori infection compared to those without it. There was a slight increase in the prevalence of endoscopic markers in those Helicobacter pylori-negative celiac subjects.
  
  
  CONCLUSIONS
  Helicobacter pylori infection seems to be less frequent in celiac patients; among those celiac subjects with concomitant Helicobacter pylori infection, histological damage degree and presence of endoscopic markers suggesting villous atrophy seem to be similar to those without Helicobacter pylori infection.
authors.forename: Juan
authors.initials: J
authors.lastname: Lasa
authors.forename: Ignacio
authors.initials: I
authors.lastname: Zubiaurre
authors.forename: Guillermo
authors.initials: G
authors.lastname: Dima
authors.forename: Daniel
authors.initials: D
authors.lastname: Peralta
authors.forename: Luis
authors.initials: L
authors.lastname: Soifer
mesh_terms: D000328:Adult; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies