title: Health Related Quality of Life in Indian Children with Cystic Fibrosis.
abstract: OBJECTIVE
  This study was devised to translate Cystic Fibrosis Questionnaire-Revised to Hindi and administer it to Indian children and adolescents diagnosed with cystic fibrosis.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  This study was carried out in cystic fibrosis patients attending Pediatric Chest Clinic of a tertiary-care hospital in Northern India from July 2012 to December 2012.
  
  
  METHODS
  45 children (6-13 years) and their parents, and 14 adolescents. Patients with unstable health in the past two weeks were excluded.
  
  
  METHODS
  Cystic Fibrosis Questionnaire- Revised translated in Hindi was administered. Clinical evaluation and scoring, throat swab cultures and spirometry were also done during the same visit.
  
  
  METHODS
  Health Related Quality of Life scores were the primary measures, and clinical scores, swab cultures and spirometry were secondary measures.
  
  
  RESULTS
  Cronbachs alpha ranged from 0.020-0.863.The Factor analysis indicated that most test-items correlated more with competing scales than the intended scales. Convergence between self and proxy-rating was found to be dependent on the domain. The Cystic Fibrosis Questionnaire- Revised scores correlated well with clinical scores (r=0.65,P=0.011), Pseudomonas spp culture data and pulmonary function tests. There was an inverse relation between Health Related Quality of Life scores and age at diagnosis (r=-0.339, P=0.02).
  
  
  CONCLUSIONS
  Hindi versions of Cystic Fibrosis Questionnaire- Revised: Child, Adolescent and Parents instruments will act as an important step towards data on Health Related Quality of Life of Indian patients with cystic fibrosis.
authors.affiliation: Departments of Pediatrics and *Biostatistics, All India Institute of Medical Sciences, New Delhi, India. Correspondence to: Dr SK Kabra, Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110 029, India. skkabra@hotmail.com.
authors.forename: Devika
authors.initials: D
authors.lastname: Kir
authors.forename: Sumita
authors.initials: S
authors.lastname: Gupta
authors.forename: George
authors.initials: G
authors.lastname: Jolly
authors.forename: M
authors.initials: M
authors.lastname: Kalaivani
authors.forename: Rakesh
authors.initials: R
authors.lastname: Lodha
authors.forename: S K
authors.initials: SK
authors.lastname: Kabra
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D011788:Quality of Life; D012720:Severity of Illness Index; D013147:Spirometry; D011795:Surveys and Questionnaires; D016896:Treatment Outcome