title: Crosslinking of alginic acid/chitosan matrices using polycarboxylic acids and their utilization for sodium diclofenac release.
abstract: Three different ratios of alginic acid/chitosan matrices of ratios 3/1, 1/1 and 1/2, respectively, were crosslinked in their dry state using citric acid (CA)/sodium hypophosphite (SHP) at different conditions controlling the crosslinking process such as citric acid concentration, citric acid/sodium hypophosphite molar ratio as well as time and temperature of reaction. Results indicate that such matrices were crosslinked efficiently on curing at 180°C for 9min in presence of CA/SHP ratio 1 and the citric acid concentration of 0.6 based on the weight of any matrices. The crosslinked matrices were characterized by investigating their swelling properties, FT-IR and thermalgravimetric analysis. Furthermore, such crosslinked matrices were tested as drug release for sodium diclofenac.
authors.affiliation: Textile Research Division, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: H M
authors.initials: HM
authors.lastname: Fahmy
authors.affiliation: Textile Research Division, National Research Centre, Dokki, Cairo, Egypt. Electronic address: fouda@trd-egypt.org.
authors.forename: Moustafa M G
authors.initials: MM
authors.lastname: Fouda
keywords: Alginic acid; Chitosan; Citric acid; Crosslinking; Drug release; Sodium diclofenac; Swelling properties