title: Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities.
abstract: Two new heterodimeric sesquiterpenes, sterhirsutins C (1) and D (2), along with eight new sesquiterpenoid derivatives, sterhirsutins E--L (3-10), were isolated from the culture of Stereum hirsutum. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possessed an unprecedented chemical skeleton with a 5/5/5/6/9/4 fused ring system. Compound 10 is the first sesquiterpene coupled with a xanthine moiety. Compounds 1-10 showed cytotoxicity against K562 and HCT116 cell lines. Compound 9 induced autophagy in HeLa cells. Compound 5 inhibited the activation of IFNβ promoter in Sendai virus infected cells.
authors.affiliation: ‡University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Qiu-Yue
authors.initials: QY
authors.lastname: Qi
authors.forename: Jin-Wei
authors.initials: JW
authors.lastname: Ren
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Sun
authors.forename: Lu-Wei
authors.initials: LW
authors.lastname: He
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.forename: Qin-Miao
authors.initials: QM
authors.lastname: Sun
authors.forename: Yi-Jian
authors.initials: YJ
authors.lastname: Yao
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Yin
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005658:Fungi / Q000737:chemistry*; D045325:HCT116 Cells / Q000737:chemistry* / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology*; D016899:Interferon-beta / Q000737:chemistry* / Q000494:pharmacology; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D029082:Sendai virus / Q000737:chemistry* / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D018609:Tibet; D019820:Xanthine / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; C000602949:sterhirsutin C; C000602950:sterhirsutin D; D019820:Xanthine; D016899:Interferon-beta