title: DNA repair in hyperthermophilic and hyperradioresistant microorganisms.
abstract: The genome of a living cell is continuously under attack by exogenous and endogenous genotoxins. Especially, life at high temperature inflicts additional stress on genomic DNA, and very high rates of potentially mutagenic DNA lesions, including deamination, depurination, and oxidation, are expected. However, the spontaneous mutation rates in hyperthermophiles are similar to that in Escherichia coli, and it is interesting to determine how the hyperthermophiles preserve their genomes under such grueling environmental conditions. In addition, organisms with extremely radioresistant phenotypes are targets for investigating special DNA repair mechanisms in extreme environments. Multiple DNA repair mechanisms have evolved in all organisms to ensure genomic stability, by preventing impediments that result in genome destabilizing lesions.
authors.affiliation: Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Fukuoka, Fukuoka 812-8581, Japan. Electronic address: ishino@agr.kyushu-u.ac.jp.
authors.forename: Yoshizumi
authors.initials: Y
authors.lastname: Ishino
authors.affiliation: Radiation Microbiology Laboratory, Department of Life Sciences, Faculty of Life Sciences, Toyo University, 1-1-1 Izumino, Itakura, Gunma 374-0193, Japan.
authors.forename: Issay
authors.initials: I
authors.lastname: Narumi
mesh_terms: D001105:Archaea / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D004260:DNA Repair; D019641:DNA, Archaeal / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D034301:Deinococcus / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics; D016680:Genome, Bacterial / Q000528:radiation effects; D042822:Genomic Instability; D006358:Hot Temperature
chemical_list: D019641:DNA, Archaeal; D004269:DNA, Bacterial