title: Differences in the prevalence and characteristics of metabolic syndrome in rheumatoid arthritis and osteoarthritis: a multicentric study.
abstract: The purpose of the study was to examine whether rheumatoid arthritis (RA) patients have higher prevalence of metabolic syndrome (MetS) than osteoarthritis (OA) patients in association with a higher level of chronic systemic inflammation in rheumatoid arthritis. A total of 583 RA and 344 OA outpatients were analyzed in this multicentric study. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. A 1.6-fold higher prevalence of MetS was found in patients with OA compared with the RA patients. Among the parameters of MetS, patients with OA had significantly higher levels of waist circumference, systolic blood pressure, fasting blood glucose and triglycerides, whereas HDL cholesterol and diastolic blood pressure values were similar in both groups of patients. Higher values of inflammatory markers [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR)] in MetS than in non-MetS patients and higher prevalence of MetS in patients with CRP level ≥5 mg/L in both RA and OA patients were found. In multivariate logistic regression analysis, significant predictors of MetS were type of arthritis (OA vs. RA; OR 2.5 [95 % CI 1.82-3.43]), age (OR 1.04 [95 % CI 1.03-1.06]) and ESR (OR 1.01; [95 % CI 1.00-1.01]). The significant association between OA and MetS was maintained in the regression model that controlled for body mass index (OR 1.87 [95 % CI 1.34-2.61]). The present analysis suggests that OA is associated with an increased risk of MetS, which may be due to a common underlying pathogenic mechanism.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, University of Zagreb School of Medicine, Av. G. Šuška 6, 10 040, Zagreb, Croatia. salamonlea@yahoo.com.
authors.forename: Lea
authors.initials: L
authors.lastname: Šalamon
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, University of Zagreb School of Medicine, Av. G. Šuška 6, 10 040, Zagreb, Croatia.
authors.forename: Jadranka
authors.initials: J
authors.lastname: Morović-Vergles
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Split University Hospital, University of Split School of Medicine, Spinčićeva 1, 21000, Split, Croatia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Marasović-Krstulović
authors.affiliation: Hospital for Cardiac, Pulmonary and Rheumatic Rehabilitation, Talassotherapia, Ul. Maršala Tita 188, 51410, Opatija, Croatia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Kehler
authors.affiliation: Department of Physical Medicine, Dubrava University Hospital, Av. G. Šuška 6, 10 040, Zagreb, Croatia.
authors.forename: Davorin
authors.initials: D
authors.lastname: Šakić
authors.affiliation: Department of Physical Medicine, Dubrava University Hospital, Av. G. Šuška 6, 10 040, Zagreb, Croatia.
authors.forename: Olga
authors.initials: O
authors.lastname: Badovinac
authors.affiliation: Department of Rehabilitation Medicine and Rheumatology, Split University Hospital, University of Split School of Medicine, Spinčićeva 1, 21000, Split, Croatia.
authors.forename: Tonko
authors.initials: T
authors.lastname: Vlak
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Clinical Hospital Center Rijeka, University of Rijeka School of Medicine, Krešimirova 42, 51000, Rijeka, Croatia.
authors.forename: Srđan
authors.initials: S
authors.lastname: Novak
authors.affiliation: Department for Rheumatology and Rehabilitation, Clinical Hospital Centre Rijeka, School of Medicine University of Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
authors.forename: Nives
authors.initials: N
authors.lastname: Štiglić-Rogoznica
authors.affiliation: Department of Rheumatic Diseases, Physical Medicine and Rehabilitation, GH ''Dr. Josip Benčević'', Andrije Štampara 42, 35000, Slavonski Brod, Croatia.
authors.forename: Marino
authors.initials: M
authors.lastname: Hanih
authors.affiliation: Department of Internal Medicine, Osijek University Hospital, Josipa Huttlera 4, 31000, Osijek, Croatia.
authors.forename: Dražen
authors.initials: D
authors.lastname: Bedeković
authors.affiliation: Department of Rheumatology, Physical and Rehabilitation, Medicine, ''Sisters of Charity'' Clinical Hospital Center, Referral Center for Spondyloarthropathies, Ministry of Health and Social Welfare, Vinogradska Cesta 29, 10000, Zagreb, Croatia.
authors.forename: Simeon
authors.initials: S
authors.lastname: Grazio
authors.affiliation: Department of Physical Medicine and Rehabilitation, Osijek University Hospital, Josipa Huttlera 4, 31000, Osijek, Croatia.
authors.forename: Mira
authors.initials: M
authors.lastname: Kadojić
authors.affiliation: Department of Internal Medicine, Osijek University Hospital, Josipa Huttlera 4, 31000, Osijek, Croatia.
authors.forename: Jasminka
authors.initials: J
authors.lastname: Milas-Ahić
authors.affiliation: Department of Internal Medicine, Osijek University Hospital, Josipa Huttlera 4, 31000, Osijek, Croatia.
authors.forename: Višnja
authors.initials: V
authors.lastname: Prus
authors.affiliation: Department for Rheumatology and Rehabilitation, Clinical Hospital Centre Rijeka, School of Medicine University of Rijeka, Krešimirova 42, 51000, Rijeka, Croatia.
authors.forename: Doris
authors.initials: D
authors.lastname: Stamenković
authors.affiliation: Department of Rehabilitation Medicine and Rheumatology, Split University Hospital, University of Split School of Medicine, Spinčićeva 1, 21000, Split, Croatia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Šošo
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, Zagreb Clinical Hospital Center, University of Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia.
authors.forename: Branimir
authors.initials: B
authors.lastname: Anić
authors.affiliation: Department of Rheumatology and Rehabilitation, Zagreb Clinical Hospital Center, University of Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia.
authors.forename: Ðurđica
authors.initials: Ð
authors.lastname: Babić-Naglić
authors.affiliation: Department of Pathophysiology, University of Zagreb School of Medicine, Šalata 3, 10000, Zagreb, Croatia.
authors.forename: Stjepan
authors.initials: S
authors.lastname: Gamulin
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D006801:Humans; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology* / Q000378:metabolism; D015995:Prevalence; D055105:Waist Circumference / Q000502:physiology
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: Inflammation; Metabolic syndrome; Osteoarthritis; Rheumatoid arthritis