title: [Relationship between blood pressure, heart rate and cardiac autonomic dysfunction in non-diabetic obese patients].
abstract: BACKGROUND
  Some studies suggest that a high heart rate (HR) would be predictive of the incidence of an elevated blood pressure (BP). Cardiac autonomic dysfunction (CAD) affects a high proportion of obese patients. CAD could be involved in BP increase. Our aim was to examine the relationship between CAD, HR and BP in obese patients without known diabetes.
  
  
  METHODS
  We included 428 overweight or obese patients. CAD was assessed by analyzing HR variations during three standard tests (Valsalva, deep breathing, lying-to-standing), which are mostly dependent on vagal control. An oral load in glucose was performed and the Matsuda index was calculated.
  
  
  RESULTS
  The population was separated in 4 groups according to the grade of CAD (no or only one abnormal test, 2 or 3 abnormal tests) and HR (< or ≥ 75 bpm). Age was similar in the four groups. Systolic (P=0.05), diastolic (P<0.005) and mean BP (P<0.001) differed significantly between the 4 groups, and was the highest in the group of patients who had 2 or 3 abnormal tests and HR ≥ 75 bpm. Matsuda index differed across the groups (P=0.018) and was the lowest in this group.
  
  
  CONCLUSIONS
  These data indicate that among overweight or obese patients with a defect in cardiac vagal activity BP is elevated only in those with a high heart rate, which is indicative of a more marked insulin resistance and probably an excess in sympathetic activity.
authors.affiliation: Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France. Electronic address: isabela.banu@jvr.aphp.fr.
authors.forename: I
authors.initials: I
authors.lastname: Banu
authors.affiliation: Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
authors.forename: M T
authors.initials: MT
authors.lastname: Nguyen
authors.affiliation: Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Hamo-Tchatchouang
authors.affiliation: Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Cosson
authors.affiliation: Service d'endocrinologie-diabétologie-nutrition, hôpital Jean-Verdier, Assistance publique-Hôpitaux de Paris, CRNH-IdF, université Paris-Nord, avenue du 14-Juillet, 93143 Bondy cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Valensi
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure; D003920:Diabetes Mellitus; D005260:Female; D006321:Heart / Q000294:innervation* / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*
keywords: Cardiac autonomic dysfunction; Dysfonction autonome cardiaque; Fréquence cardiaque; Heart rate; Hypertension; Hypertension artérielle; Insulin resistance; Insulinorésistance; Obesity; Obésité