title: Postprandial effects on arterial stiffness parameters in healthy young adults.
abstract: Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid-femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS.
authors.affiliation: University of California San Francisco, San Francisco, CA, USA Baylor College of Medicine, Houston, TX, USA Tyler.Murray@ucsf.edu.
authors.forename: Tyler
authors.initials: T
authors.lastname: Murray
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: Eric Y
authors.initials: EY
authors.lastname: Yang
authors.affiliation: Baylor College of Medicine, Houston, TX, USA The Methodist Hospital-Michael E Debakey Heart and Vascular Institute, Houston, TX, USA.
authors.forename: Gerd
authors.initials: G
authors.lastname: Brunner
authors.affiliation: Baylor College of Medicine, Houston, TX, USA Duke University Medical Center, Durham, NC, USA.
authors.forename: Anirudh
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Baylor College of Medicine, Houston, TX, USA Harris County Hospital District - Ben Taub General Hospital, Houston, TX, USA.
authors.forename: Nasser
authors.initials: N
authors.lastname: Lakkis
authors.affiliation: Baylor College of Medicine, Houston, TX, USA Harris County Hospital District - Ben Taub General Hospital, Houston, TX, USA.
authors.forename: Arunima
authors.initials: A
authors.lastname: Misra
authors.affiliation: Baylor College of Medicine, Houston, TX, USA The Methodist Hospital-Michael E Debakey Heart and Vascular Institute, Houston, TX, USA Michael E Debakey Veterans Affairs Hospital, Houston, TX, USA.
authors.forename: Salim S
authors.initials: SS
authors.lastname: Virani
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Hartley
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Morrisett
authors.affiliation: Baylor College of Medicine, Houston, TX, USA The Methodist Hospital-Michael E Debakey Heart and Vascular Institute, Houston, TX, USA.
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
authors.affiliation: Baylor College of Medicine, Houston, TX, USA The Methodist Hospital-Michael E Debakey Heart and Vascular Institute, Houston, TX, USA Michael E Debakey Veterans Affairs Hospital, Houston, TX, USA.
authors.forename: Vijay
authors.initials: V
authors.lastname: Nambi
mesh_terms: D000328:Adult; D000367:Age Factors; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D010865:Pilot Projects; D019518:Postprandial Period; D063177:Pulse Wave Analysis; D013997:Time Factors; D014463:Ultrasonography; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D004041:Dietary Fats
keywords: Arterial distension period; arterial stiffness; postprandial lipemia; pulse wave velocity