title: Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population.
abstract: BACKGROUND
  Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. To date, the predisposition of TREM-1 gene polymorphisms to septic shock has not been reported. This study was designed to investigate whether TREM-1 genomic variations are associated with the development of septic shock.
  
  
  METHODS
  We genotyped two TREM-1 single nucleotide polymorphisms (SNPs, rs2234237 and rs2234246) and evaluated the relationships between these SNPs and septic shock on susceptibility and prognosis.
  
  
  RESULTS
  TREM-1 rs2234246 A allele in the promoter region was significantly associated with the susceptibility of septic shock in recessive model (AA, OR=3.10, 95%CI 1.15 to 8.32, P=0.02), and in codominant model (AG, OR=0.72, 95%CI 0.43-1.19, P=0.02; AA, OR=2.71, 95%CI 1.00-7.42; P=0.03). However, in three inherited models (dominant model, recessive model, and codominant model), none of the assayed loci was significantly associated with the prognosis of septic shock. The non-survivor group demonstrated higher plasma IL-6 levels (99.7±34.7 pg/mL vs. 61.2±26.5 pg/mL, P<0.01) than the survivor group. Plasma concentrations of IL-6 among the three genotypes of rs2234246 were AA 99.4±48.9 pg/mL, AG 85.4±43 pg/mL, and GG 65.3±30.7 pg/mL (P<0.01). The plasma concentrations of IL-6 in patients with AA genotypes were significantly higher than those in patients with GG genotypes (P<0.01).
  
  
  CONCLUSIONS
  TREM-1 genetic polymorphisms rs2234246 may be significantly correlated only with susceptibility to septic shock in the Chinese Han population.
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Liang-Shan
authors.initials: LS
authors.lastname: Peng
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Gao-Sheng
authors.initials: GS
authors.lastname: Zhou
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Lie-Hua
authors.initials: LH
authors.lastname: Deng
authors.affiliation: Department of Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Hua-Guo
authors.initials: HG
authors.lastname: Yao
keywords: Association study; Septic shock; Single nucleotide polymorphisms; Triggering receptor expressed on myeloid cells-1