title: Metabolic regulation in model ascomycetes--adjusting similar genomes to different lifestyles.
abstract: The related yeasts Saccharomyces cerevisiae and Candida albicans have similar genomes but very different lifestyles. These fungi have modified transcriptional and post-translational regulatory processes to adapt their similar genomes to the distinct biological requirements of the two yeasts. We review recent findings comparing the differences between these species, highlighting how they have achieved specialized metabolic capacities tailored to their lifestyles despite sharing similar genomes. Studying this transcriptional and post-transcriptional rewiring may improve our ability to interpret phenotype from genotype.
authors.affiliation: Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada. Electronic address: malcolm.whiteway@concordia.ca.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Whiteway
authors.affiliation: Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Walters A
authors.initials: WA
authors.lastname: Tebung
authors.affiliation: Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Baharul I
authors.initials: BI
authors.lastname: Choudhury
authors.affiliation: Biology Department, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Ortiz
mesh_terms: D001203:Ascomycota / Q000235:genetics* / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism; D016681:Genome, Fungal; D008957:Models, Genetic; D046912:Multiprotein Complexes / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D046912:Multiprotein Complexes; D002244:Carbon
keywords: Candida albicans; Saccharomyces cerevisiae; fungal metabolism; transcriptional regulators; transcriptional rewiring