title: The association between endometrial polyps and metabolic syndrome: a case-control study.
abstract: BACKGROUND
  Endometrial polyps are common benign gynaecologic disorders. The etiopathogenesis of this condition remains unclear, however obesity is an important risk factor for the development of endometrial polyps.
  
  
  OBJECTIVE
  The aim of the study was to evaluate a possible association between endometrial polyps and clinical parameters of metabolic syndrome (MetS).
  
  
  METHODS
  Forty-five women with endometrial polyps (study group) and 45 without (control group) were included in this cross-sectional study. The main parameters evaluated between the groups were age, BMI (body mass index), waist circumference (WC), blood pressure, serum lipid profiles, fasting glucose levels and homeostatic model assessment of insulin resistance (HOMA-IR).
  
  
  RESULTS
  There was a significant difference between the groups in terms of BMI, WC, insulin levels and HOMA-IR (P < 0.05). The MetS was present in 32 (71.1%) of women in the study group and in 6 (13.3%) in the control group (P < 0.001). Logistic regression demonstrated that MetS was a significant risk factor for endometrial polyps. ROC curve analysis also showed that MetS was the most significant discriminative risk factor in the study group with an AUC of 0.789 (0.691-0.887; CI 95%).
  
  
  CONCLUSIONS
  Our study suggests that there may be a relationship between endometrial polyps, MetS and insulin resistance. Further studies are required to explain the role of this relationship in the pathogenesis of the disease.
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Nazlı Topfedaisi
authors.initials: NT
authors.lastname: Özkan
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Ali İrfan
authors.initials: Aİ
authors.lastname: Güzel
authors.affiliation: Department of Cardiology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Selçuk
authors.initials: S
authors.lastname: Özkan
authors.affiliation: Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Mahmut Nedim
authors.initials: MN
authors.lastname: çİçek
mesh_terms: D000328:Adult; D000367:Age Factors; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D011127:Polyps / Q000453:epidemiology*; D012372:ROC Curve; D012307:Risk Factors; D014591:Uterine Diseases / Q000453:epidemiology*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008055:Lipids
keywords: endometrial polyps; insulin resistance; metabolic syndrome; risk factors