title: Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys.
abstract: Five types of porous Nickel-Titanium (NiTi) alloy samples of different porosities and pore sizes were fabricated. According to compressive and fracture strengths, three groups of porous NiTi alloy samples underwent further cytocompatibility experiments. Porous NiTi alloys exhibited a lower Young's modulus (2.0 GPa ~ 0.8 GPa). Both compressive strength (108.8 MPa ~ 56.2 MPa) and fracture strength (64.6 MPa ~ 41.6 MPa) decreased gradually with increasing mean pore size (MPS). Cells grew and spread well on all porous NiTi alloy samples. Cells attached more strongly on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cell adhesion on porous NiTi alloys was correlated negatively to MPS (277.2 μm ~ 566.5 μm; p < 0.05). More cells proliferated on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cellular ALP activity on all porous NiTi alloy samples was higher than on control group and blank group (p < 0.05). The porous NiTi alloys with optimized pore size could be a potential orthopedic material.
authors.affiliation: Institute of Stomatological Research, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, The Peoples Republic of China.
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: Jian
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, The Peoples Republic of China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, The Peoples Republic of China.
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.affiliation: Dows Institute for Dental Research College of Dentistry, University of Iowa, Iowa city, Iowa, United States of America.
authors.forename: Clark
authors.initials: C
authors.lastname: Stanford
authors.affiliation: Department of Metallic Materials Science and Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, Guangdong, The Peoples Republic of China.
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: Department of Prosthodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong, The Peoples Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D002448:Cell Adhesion; D002460:Cell Line; D002465:Cell Movement; D049109:Cell Proliferation; D019245:Compressive Strength; D003722:Dental Alloys / Q000737:chemistry* / Q000378:metabolism; D055119:Elastic Modulus; D006801:Humans; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry* / Q000378:metabolism; D016062:Porosity; D014025:Titanium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D003722:Dental Alloys; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium; D000469:Alkaline Phosphatase