title: Characteristics and Prognosis of Allergic Proctocolitis in Infants.
abstract: OBJECTIVE
  The dietary protein proctocolitis, also known as allergic proctocolitis (AP), is characterized by the presence of mucoid, frothy, and bloody stools in an otherwise healthy infant. The aim of this study was to describe a group of children with AP, diagnosed according to the criterion-standard method, food challenge to provide clinicians with more information on typical presentation, and an overview on nutritional management strategies and prognosis.
  
  
  METHODS
  We collected data on infants with AP in our allergy and gastroenterology outpatient clinics. Any other conditions that may cause bloody diarrhea were ruled out. Skin prick tests and atopy patch tests were performed for diagnosis, and patients were studied for resolution. To the patients whose rectal bleeding did not recover with oligoantigenic maternal diet in addition to amino acid-based formula, endoscopic evaluation was performed to confirm the diagnosis and to exclude other reasons of rectal bleeding.
  
  
  RESULTS
  Sixty patients were diagnosed as having AP. The age of onset was 1.7 ± 1.32 months. All of the patients were triggered by milk, 6.6% with milk and egg, 3.3% with milk and chicken, 1.7% with milk and wheat, 1.7% with milk and potato, and 3.3% had multiple food allergy. 53.3% (n = 32) acquired tolerance by age 1, 25.0% (n = 15) by 2 years, 5% (n = 3) by 3, and 1.7% (n = 1) by 4 years.
  
  
  CONCLUSIONS
  Milk was a triggering factor for all of the patients. Resolution of AP is usually within 1 year but symptoms of some patients may continue even longer. An extension of the follow-up period is required according to our study.
authors.affiliation: *Department of Pediatric Allergy and Immunology †Department of Pediatric Gastroenterology, Ankara Children's Hematology Oncology Training and Research Hospital, Ankara ‡Department of Pediatric Allergy and Immunology, Mugla Sıtkı Kocman University, Mugla, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Kaya
authors.forename: Muge
authors.initials: M
authors.lastname: Toyran
authors.forename: Ersoy
authors.initials: E
authors.lastname: Civelek
authors.forename: Emine
authors.initials: E
authors.lastname: Misirlioglu
authors.forename: Ceyda
authors.initials: C
authors.lastname: Kirsaclioglu
authors.forename: Can N
authors.initials: CN
authors.lastname: Kocabas
mesh_terms: D017668:Age of Onset; D000818:Animals; D003876:Dermatitis, Atopic / Q000209:etiology; D004032:Diet / Q000009:adverse effects*; D004044:Dietary Proteins / Q000276:immunology*; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000150:complications*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008892:Milk / Q000276:immunology*; D016269:Milk Hypersensitivity / Q000097:blood / Q000150:complications; D011350:Proctocolitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D011379:Prognosis
chemical_list: D004044:Dietary Proteins; D007073:Immunoglobulin E