title: [Are we on the verge of lung-cancer screening in the Netherlands?].
abstract: Previous studies of low-dose computed tomography (CT) screening for lung cancer have shown a decrease in lung-cancer-related deaths. Data from the NELSON trial, using new thresholds for defining a positive test, resulted in less over-diagnosis without a decrease in test-specific sensitivity. However, in our opinion it is still too early to implement screening in the Netherlands. Further development of the optimal screening algorithm based on defined volumetric thresholds and stratified by personal characteristics such as age, smoking habits, gender and comorbidities, will probably result in a better balance between the harms and benefits of lung-cancer screening to individuals and society.
authors.affiliation: OLVG, afd. Longziekten, Amsterdam.
authors.forename: Arthur A J
authors.initials: AA
authors.lastname: Smit
authors.forename: Arifa
authors.initials: A
authors.lastname: Moons-Pasic
authors.forename: Paul
authors.initials: P
authors.lastname: Bresser
mesh_terms: D003362:Cost-Benefit Analysis; D055088:Early Detection of Cancer; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000191:economics; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D009426:Netherlands; D012307:Risk Factors; D012907:Smoking; D014057:Tomography, X-Ray Computed