title: TAFRO syndrome: 2 cases and review of the literature.
abstract: Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome and have reviewed another eighteen previously reported cases. Histological findings of the lymph nodes and levels of interleukin 6 (IL-6) and vascular endothelial growth factor in both serum/plasma and effusions are important characteristics for diagnosing this syndrome.
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Mikako
authors.initials: M
authors.lastname: Kawashima
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Usui
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Mori
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamauchi
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kajita
authors.affiliation: b Pathology division, Gifu University Hospital , Gifu , Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kito
authors.affiliation: b Pathology division, Gifu University Hospital , Gifu , Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: c Center of General Internal Medicine and Rheumatology, Gifu Municipal Hospital , Gifu , Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Fujioka
authors.affiliation: c Center of General Internal Medicine and Rheumatology, Gifu Municipal Hospital , Gifu , Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ishizuka
authors.affiliation: a Department of General Internal Medicine , Gifu University Hospital , Gifu , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
mesh_terms: D000328:Adult; D005871:Castleman Disease / Q000175:diagnosis*; D004487:Edema / Q000175:diagnosis*; D005334:Fever / Q000175:diagnosis*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007564:Japan; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D013577:Syndrome; D013921:Thrombocytopenia / Q000175:diagnosis*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Anasarca; Fever; Organomegaly; Reticulin fibrosis; Thrombocytopenia