title: Regioselective Metal-Free Cross-Coupling of Quinoline N-Oxides with Boronic Acids.
abstract: A novel and operationally simple one-step C-H bond functionalization of quinoline N-oxides to 2-substituted quinolines was developed. This approach enables the regioselective functionalization under external oxidant- and metal-free conditions. The developed transformation represents the first application of the Petasis reaction in functionalization of heterocycles.
authors.affiliation: †Abteilung Chemische Biologie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|‡Fakultät für Chemie und Chemische Biologie, Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
authors.forename: Luis
authors.initials: L
authors.lastname: Bering
authors.affiliation: †Abteilung Chemische Biologie, Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.|‡Fakultät für Chemie und Chemische Biologie, Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany.
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003497:Cyclic N-Oxides / Q000737:chemistry*; D006860:Hydrogen Bonding; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D003497:Cyclic N-Oxides; D008670:Metals; D016877:Oxidants; D011804:Quinolines