title: Effect of transforming growth factor-β1 869C/T polymorphism and radiation pneumonitis.
abstract: BACKGROUND
  The Transforming growth factor-β1 (TGFβ1) 869C/T polymorphism was associated with radiation pneumonitis (RP) susceptibility. However, the results remained controversial. Thus, a meta-analysis was conducted.
  
  
  METHODS
  Relevant studies were systematically searched by using the NCBI, Medline, Web of Science and Embase databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models.
  
  
  RESULTS
  There was a significant association between TGFβ1 869C/T polymorphism and RP susceptibility (OR=1.77; 95% CI, 1.27-2.47; P=0.0007).
  
  
  CONCLUSIONS
  This study suggested that TGFβ1 869C/T polymorphism was a risk factor of RP.
authors.affiliation: Department of Respiratory Medicine, Dongying People's Hospital of Shandong Province Dongying 257091, Shandong, China.
authors.forename: Yingtian
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China.
authors.forename: Xingguang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Qianfo Mountain Hospital of Shandong University Jinan 250014, Shandong, China.
authors.forename: Xiyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Dongying People's Hospital of Shandong Province Dongying 257091, Shandong, China.
authors.forename: Deyong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Jiang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D017564:Radiation Pneumonitis / Q000175:diagnosis / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
keywords: Radiation pneumonitis; meta-analysis; polymorphism; transforming growth factor