title: Catalytic asymmetric desymmetrization of N-arylmaleimides: efficient construction of both atom chirality and axial chirality.
abstract: The catalytic asymmetric Michael addition/desymmetrization reaction of N-(2-t-butylphenyl)maleimides with unprotected 3-substituted-2-oxindoles was successfully realized using a chiral N,N'-dioxide-Sc(III) complex, leading to succinimides with two kinds of stereogenic elements—atom chirality and axial chirality—in up to 99% yield, 99% ee and >19 : 1 d.r.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China. xmfeng@scu.edu.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Zhang
authors.forename: Yulong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Qian
authors.initials: Q
authors.lastname: Yao
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng