title: A novel Peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity.
abstract: Deoxynivalenol (DON) is a type B trichothecene mycotoxin that is commonly detected in cereals and grains world-wide. The low-tolerated levels of this mycotoxin, especially in mono-gastric animals, reflect its bio-potency. The toxicity of DON is conventionally attributed to its ability to inhibit ribosomal protein biosynthesis, but recent advances in molecular tools have elucidated novel mechanisms that further explain DON's toxicological profile, complementing the diverse symptoms associated with its exposure. This article summarizes the recent findings related to novel mechanisms of DON toxicity as well as how structural modifications to DON alter its potency. In addition, it explores feasible ways of expanding our understating of DON-cellular targets and their roles in DON toxicity, clearance, and detoxification through the utilization of computational biology approaches.
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. yousef.hassan@agr.gc.ca.
authors.forename: Yousef I
authors.initials: YI
authors.lastname: Hassan
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. christina.watts@agr.gc.ca.
authors.forename: Christena
authors.initials: C
authors.lastname: Watts
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. xiu-zhen.li@agr.gc.ca.
authors.forename: Xiu-Zhen
authors.initials: XZ
authors.lastname: Li
authors.affiliation: Guelph Food Research Centre, Agriculture and Agri-Food Canada (AAFC), Guelph, ON N1G 5C9, Canada. Ting.Zhou@agr.gc.ca.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhou
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D016678:Genome; D006801:Humans; D010455:Peptides / Q000378:metabolism; D011485:Protein Binding; D014255:Trichothecenes / Q000737:chemistry / Q000633:toxicity*
chemical_list: D010455:Peptides; D014255:Trichothecenes; C007262:deoxynivalenol
keywords: computational biology; deoxynivalenol; enzyme; modification; toxicity