title: Silver-based wound dressings reduce bacterial burden and promote wound healing.
abstract: Various types of wound dressings have been designed for different purposes and functions. Controlling bacterial burden in a wound during the early phase is important for successful wound repair. Once bacterial burden is under control, the active promotion of wound healing is another important factor for efficient wound healing. This study investigated the potential of three silver-containing dressings, namely KoCarbonAg(®) , Aquacel(®) Ag and Acticoat 7, in reducing bacterial survival and promoting wound healing. The ability of these dressings to block the entry of bacteria from external environment and retain intrinsic bacteria was studied in vitro. In addition, the study used a rat model to compare the healing efficiencies of the three dressings and investigate the quantity of collagen synthesis in vivo. In vitro results indicated that the silver-containing dressings prevented bacterial growth in wounds by blocking the entry of external bacteria and by retaining the bacteria in the dressing. In vivo study indicated that reduction in bacterial burden accelerated wound healing. Wounds treated by the silver-containing dressings showed better healing than those treated with gauze. Moreover, KoCarbonAg(®) further accelerated wound healing by promoting collagen synthesis and arrangement.
authors.affiliation: Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
authors.forename: Yu-Hsin
authors.initials: YH
authors.lastname: Lin
authors.affiliation: R&D Center, Bio-medical Carbon Technology Co., Ltd., Taichung, Taiwan.
authors.forename: Wei-Shan
authors.initials: WS
authors.lastname: Hsu
authors.affiliation: R&D Center, Bio-medical Carbon Technology Co., Ltd., Taichung, Taiwan.
authors.forename: Wan-Yu
authors.initials: WY
authors.lastname: Chung
authors.affiliation: Department of Materials Science and Engineering, Feng Chia University, Taichung, Taiwan.
authors.forename: Tse-Hao
authors.initials: TH
authors.lastname: Ko
authors.affiliation: R&D Center, Bio-medical Carbon Technology Co., Ltd., Taichung, Taiwan.
authors.forename: Jui-Hsiang
authors.initials: JH
authors.lastname: Lin
mesh_terms: D000818:Animals; D001458:Bandages; D002056:Burns; D002266:Carboxymethylcellulose Sodium; D051381:Rats; D012834:Silver; D014945:Wound Healing
chemical_list: D012834:Silver; D002266:Carboxymethylcellulose Sodium
keywords: Bacterial burden; Collagen synthesis; KoCarbonAg®; Silver-containing dressing