title: MAPK8-mediated stabilization of SP1 is essential for RUNX1-RUNX1T1 - driven leukaemia.
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. alba.maiques-diaz@cruk.manchester.ac.uk, salvarez@nimgenetics.com.
authors.forename: Alba
authors.initials: A
authors.lastname: Maiques-Diaz
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Miriam
authors.initials: M
authors.lastname: Hernando
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Amanda
authors.initials: A
authors.lastname: Sánchez-López
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Rio-Machin
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Shrestha
authors.affiliation: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Mulloy
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Cigudosa
authors.affiliation: Molecular Cytogenetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. salvarez@nimgenetics.com.
authors.forename: Sara
authors.initials: S
authors.lastname: Alvarez
mesh_terms: D045744:Cell Line, Tumor; D050676:Core Binding Factor Alpha 2 Subunit / Q000502:physiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D048055:Mitogen-Activated Protein Kinase 8 / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000502:physiology*; D000075142:RUNX1 Translocation Partner 1 Protein; D016329:Sp1 Transcription Factor / Q000378:metabolism*
chemical_list: C107844:AML1-ETO fusion protein, human; D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; D000075142:RUNX1 Translocation Partner 1 Protein; D016329:Sp1 Transcription Factor; C108209:SP1 protein, human; D048055:Mitogen-Activated Protein Kinase 8
keywords: CDKN1A; MAPK8/JNK1; RUNX1/RUNX1T1; SP1; myeloid leukaemia