title: Precise protein post-translational modifications modulate ABI5 activity.
abstract: Abscisic acid-insensitive 5 (ABI5), a plant basic leucine zipper (bZIP) transcription factor, has been revealed to be the key regulator in the abscisic acid (ABA) signaling pathway controlling seed dormancy, germination, plant growth, and flowering time. Recently, new evidence has come to light that a combination of different post-translational modifications (PTMs) might together control the stability and activity of ABI5. In this review, we highlight three types of PTM (protein phosphorylation/dephosphorylation, ubiquitination, and sumoylation) and their interactions that precisely regulate ABI5 signaling. ABI5 is the best-studied key molecule in the ABA signaling pathway with respect to PTMs; therefore, this review could serve as a model to guide post-translational studies of important regulators in other plant hormone signaling pathways.
authors.affiliation: State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Feifei
authors.initials: F
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, PR China.
authors.forename: Yaorong
authors.initials: Y
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Plant Genomics, National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: qxie@genetics.ac.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xie
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D050976:Basic-Leucine Zipper Transcription Factors / Q000378:metabolism*; D010766:Phosphorylation; D010937:Plant Growth Regulators / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D058207:Sumoylation; D054875:Ubiquitination
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D010937:Plant Growth Regulators; D010940:Plant Proteins; D000040:Abscisic Acid
keywords: (de-)phosphorylation; ABA signaling; ABI5; sumoylation; ubiquitination