title: Refining the nuclear auxin response pathway through structural biology.
abstract: Auxin is a key regulator of plant growth and development. Classical molecular and genetic techniques employed over the past 20 years identified the major players in auxin-mediated gene expression and suggest a canonical auxin response pathway. In recent years, structural and biophysical studies clarified the molecular details of auxin perception, the recognition of DNA by auxin transcription factors, and the interaction of auxin transcription factors with repressor proteins. These studies refine the auxin signal transduction model and raise new questions that increase the complexity of auxin signaling.
authors.affiliation: Department of Biology, Washington University, St. Louis, MO 63130, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Korasick
authors.affiliation: Department of Biology, Washington University, St. Louis, MO 63130, USA. Electronic address: jjez@wustl.edu.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Jez
authors.affiliation: Department of Biology, Washington University, St. Louis, MO 63130, USA. Electronic address: strader@wustl.edu.
authors.forename: Lucia C
authors.initials: LC
authors.lastname: Strader
mesh_terms: D007210:Indoleacetic Acids / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism*; D010940:Plant Proteins / Q000235:genetics* / Q000378:metabolism; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D007210:Indoleacetic Acids; D010937:Plant Growth Regulators; D010940:Plant Proteins; D012097:Repressor Proteins; D014157:Transcription Factors