title: Plasma adiponectin and carotid intima-media thickness in non-obese patients with type 2 diabetes.
abstract: OBJECTIVE
  We assessed the correlation between plasma adiponectin levels and carotid intima media thickness (IMT), as a marker of atherosclerosis, in non-obese patients with type 2 diabetes.
  
  
  METHODS
  The study group included 112 (60 males and 52 females) non-obese Egyptian patients with type 2 diabetes. Fasting plasma adiponectin was measured using ELISA technique. Carotid IMT was assessed using high-resolution color- coded Doppler ultrasonography. Forty age, sex and weight matched normal Egyptian subjects were included in the study as a control group.
  
  
  RESULTS
  A non-significant inverse correlation was found between plasma adiponectin levels and carotid IMT in the study group (p=0.054). Multiple regression analysis revealed that plasma adiponectin was not a determinant of carotid IMT in the study group (p=0.061).
  
  
  CONCLUSIONS
  The inverse relation between plasma adiponectin and carotid IMT in type 2 diabetes could be explained, at least partially, by obesity.
authors.affiliation: Internal Medicine Department, Cairo University, Egypt. Electronic address: aasemsaif@yahoo.com.
authors.forename: Aasem
authors.initials: A
authors.lastname: Saif
authors.affiliation: Vascular Laboratory, Cairo University, Egypt.
authors.forename: Alaa
authors.initials: A
authors.lastname: Abdelhamid
authors.affiliation: Internal Medicine Department, Cairo University, Egypt.
authors.forename: Maha
authors.initials: M
authors.lastname: Assem
authors.affiliation: Internal Medicine Department, Cairo University, Egypt.
authors.forename: Shrook
authors.initials: S
authors.lastname: Mousa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050197:Atherosclerosis / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000097:blood; D059168:Carotid Intima-Media Thickness; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; Atherosclerosis; Carotid intima–media thickness; Doppler ultrasonography; Type 2 diabetes