title: Acute exacerbation of rheumatoid interstitial lung disease during the maintenance therapy with certolizumab pegol.
abstract: We report a case involving a 68-year-old woman with rheumatoid arthritis (RA) with acute exacerbated interstitial lung disease (ILD) during certolizumab pegol maintenance therapy. She recovered quickly with steroid pulse therapy and was discharged without deterioration of basal pulmonary function. Immunoblot analysis demonstrated the circulating cleaved interleukin-1β at the phase of acute exacerbation of RA-associated ILD (RA-ILD) in this patient. The findings from this case suggested that the Nod-like receptor pyrin domain-containing protein 3 inflammasome is implicated in acute RA-ILD exacerbation.
authors.affiliation: a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.affiliation: a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Tsuji
authors.affiliation: b Department of Respiratory Medicine , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Hisatomi
authors.affiliation: a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Riyoko
authors.initials: R
authors.lastname: Shigeno
authors.affiliation: a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Yasumori
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: a Department of Rheumatology and Clinical Research Center , Nagasaki Medical Center , Omura, Nagasaki , Japan.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Iwanaga
authors.affiliation: c First Department of Internal Medicine , Nagasaki University School of Medicine , Sakamoto, Nagasaki , Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D000068582:Certolizumab Pegol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy*
chemical_list: D018501:Antirheumatic Agents; D000068582:Certolizumab Pegol
keywords: Certolizumab pegol; Inflammasome; Interleukin-1β; Interstitial lung disease; Rheumatoid arthritis