title: IL-33 and Thymic Stromal Lymphopoietin in mast cell functions.
abstract: Thymic Stromal Lymphopoietin (TSLP) and Interleukin 33 (IL-33) are two cytokines released by cells that are in proximity to our environment, e.g., keratinocytes of the skin and epithelial cells of the airways. Pathogens, allergens, chemicals and other agents induce the release of TSLP and IL-33, which are recognized by mast cells. TSLP and IL-33 affect several mast cell functions, including growth, survival and mediator release. These molecules do not directly induce exocytosis, but cause release of de novo synthesized lipid mediators and cytokines. TSLP and IL-33 are also implicated in inflammatory diseases where mast cells are known to be an important part of the pathogenesis, e.g., asthma and atopic dermatitis. In this chapter we describe and discuss the implications of TSLP and IL-33 on mast cell functions in health and disease.
authors.affiliation: Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin, Berlin, Germany. Electronic address: drrohitsaluja@gmail.com.
authors.forename: Rohit
authors.initials: R
authors.lastname: Saluja
authors.affiliation: Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Zoltowska
authors.affiliation: University of Groningen, Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Maria Elizabeth
authors.initials: ME
authors.lastname: Ketelaar
authors.affiliation: Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. Electronic address: gunnar.p.nilsson@ki.se.
authors.forename: Gunnar
authors.initials: G
authors.lastname: Nilsson
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism; D000067596:Interleukin-33 / Q000378:metabolism*; D008407:Mast Cells / Q000166:cytology* / Q000378:metabolism; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D000067596:Interleukin-33; D000094632:Thymic Stromal Lymphopoietin
keywords: Allergic asthma; Atopic dermatitis; IL-33; Mast cell; TSLP