title: [The functional aspects of bacterial CRISPR-cas systems and interactions between phages and its bacterial hosts--a review].
abstract: The roles of CRIPR-Cas systems in bacterial host protection against mobile genetic elements ( MGEs) are now well known, but there is mounting evidence that these systems modulate other processes, such as the genetic regulation of group behavior and virulence, DNA repair and genome evolution. Here, we reviewed the structure, types and mechanism of interference of CRISPR-Cas system as well as the additional functions of CRISPR-Cas beyond adaptive immunity. Furthermore, we discussed the mechanisms for phages to overcome bacterial CRISPR-Cas system, and the prospective evolution of interactions between phage and host.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Jianhe
authors.initials: J
authors.lastname: Sun
authors.forename: Yaxian
authors.initials: Y
authors.lastname: Yan
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000235:genetics / Q000276:immunology / Q000821:virology*; D001435:Bacteriophages / Q000502:physiology*; D064113:CRISPR-Cas Systems; D054884:Host-Pathogen Interactions