title: Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans.
abstract: Candida albicans, one of the pathogenic Candida species, causes high mortality rate in immunocompromised and high-risk surgical patients. In the last decade, only one new class of antifungal drug echinocandin was applied. The increased therapy failures, such as the one caused by multi-drug resistance, demand innovative strategies for new effective antifungal drugs. Synergistic combinations of antifungals and anti-virulence agents highlight the pragmatic strategy to reduce the development of drug resistant and potentially repurpose known antifungals, which bypass the costly and time-consuming pipeline of new drug development. Anti-virulence and synergistic combination provide new options for antifungal drug discovery by counteracting the difficulty or failure of traditional therapy for fungal infections.
authors.affiliation: a CAS Key Laboratory of Pathogenic Microbiology and Immunology; Institute of Microbiology; Chinese Academy of Sciences ; Beijing , China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Cui
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Tong
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000592:standards / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects* / Q000472:pathogenicity*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D002986:Clinical Trials as Topic; D025141:Drug Resistance, Fungal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests; D014774:Virulence / Q000187:drug effects
chemical_list: D000935:Antifungal Agents
keywords: Candida albicans; antifungal drug; drug resistance; synergy; virulence factors