title: Molecular mechanisms controlling the migration of striatal interneurons.
abstract: In the developing telencephalon, the medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While the molecular mechanisms controlling the migration of interneurons to the cortex have been extensively studied, very little is known about the nature of the signals that guide interneurons to the striatum. Here we report that the allocation of MGE-derived interneurons in the developing striatum of the mouse relies on a combination of chemoattractive and chemorepulsive activities. Specifically, interneurons migrate toward the striatum in response to Nrg1/ErbB4 chemoattraction, and avoid migrating into the adjacent cortical territories by a repulsive activity mediated by EphB/ephrinB signaling. Our results also suggest that the responsiveness of MGE-derived striatal interneurons to these cues is at least in part controlled by the postmitotic activity of the transcription factor Nkx2-1. This study therefore reveals parallel mechanisms for the migration of MGE-derived interneurons to the striatum and the cerebral cortex.
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: Verona
authors.initials: V
authors.lastname: Villar-Cerviño
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kappeler
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: Sandrina
authors.identifier: http://orcid.org/0000-0002-9652-1382
authors.initials: S
authors.lastname: Nóbrega-Pereira
authors.affiliation: Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, and.
authors.forename: Mark
authors.initials: M
authors.lastname: Henkemeyer
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: Luciano
authors.identifier: http://orcid.org/0000-0002-1297-7615
authors.initials: L
authors.lastname: Rago
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
authors.forename: M Angela
authors.initials: MA
authors.lastname: Nieto
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain, MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, London SE1 1UL, United Kingdom oscar.marin@kcl.ac.uk.
authors.forename: Oscar
authors.identifier: http://orcid.org/0000-0001-6264-7027
authors.initials: O
authors.lastname: Marín
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation; D002465:Cell Movement / Q000235:genetics*; D002525:Cerebellar Cortex / Q000166:cytology; D003342:Corpus Striatum / Q000166:cytology*; D004622:Embryo, Mammalian; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D066298:In Vitro Techniques; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation / Q000235:genetics; D009434:Neural Pathways / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D009924:Organ Culture Techniques; D036225:Receptor, EphB1 / Q000235:genetics / Q000378:metabolism; D036223:Receptor, EphB3 / Q000235:genetics / Q000378:metabolism; D066247:Receptor, ErbB-4 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013687:Telencephalon / Q000166:cytology / Q000196:embryology; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: C000614414:Nkx2-1 protein, mouse; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; C587689:ERBB4 protein, human; D036225:Receptor, EphB1; D036223:Receptor, EphB3; D066247:Receptor, ErbB-4
keywords: Eph; ErbB4; GABAergic; interneuron; migration; striatum