title: Epstein-Barr virus latent membrane protein 2A mediated activation of Sonic Hedgehog pathway induces HLA class Ia downregulation in gastric cancer cells.
abstract: One of the immune evasion strategies manifested by malignant cells is the downregulation of the Human Leukocyte Antigen (HLA). HLA Class I (HLA- A, -B, -C) present endogenous peptides including viral and tumor antigens to cytotoxic T lymphocytes for immune mediated destruction. We have found the Epstein Barr Virus (EBV) Latent Membrane Protein 2A (LMP2A) to be responsible for this HLA downregulation in gastric cancer cells. Our results further indicate the Sonic Hedgehog pathway; primarily Gli1 to bring about the LMP2A mediated decrease in HLA expression.
authors.affiliation: Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064, India.
authors.forename: Anindita
authors.initials: A
authors.lastname: Deb Pal
authors.affiliation: Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064, India. Electronic address: subrata.banerjee@saha.ac.in.
authors.forename: Subrata
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D045744:Cell Line, Tumor; D015536:Down-Regulation; D004847:Epithelial Cells / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis*; D054884:Host-Pathogen Interactions; D006801:Humans; D014157:Transcription Factors / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; C400551:GLI1 protein, human; D015395:Histocompatibility Antigens Class I; D014157:Transcription Factors; D014763:Viral Matrix Proteins; D000071676:Zinc Finger Protein GLI1
keywords: Epstein Barr Virus; Gastric Cancer; Gli1; Human Leukocyte Antigen; LMP2A; Sonic Hedgehog pathway