title: Synchronous two distinct neuroendocrine lung cancer lesions.
abstract: The synchronous primary lung tumors is a rare condition and presented patient is the first reported case of simultaneous two distinct neuroendocrine lung cancer lesions in the same lobe. We present the case of a 55-year-old woman with synchronous two distinct neuroendocrine lung cancer lesions in the right upper lobe. Initially she showed no signs or symptoms related to lung lesions and was admitted to Thoracic Surgery Ward for the investigation of two oval, solitary pulmonary nodules (11 and 19 mm in diameter) detected on a chest X-ray performed three months earlier. The radiological imaging showed a variability of growth of both lesions (smaller tumor has enlarged while the larger one remained unchanged). After the CT-guided lung biopsy, patient underwent right upper lobectomy. Histological examination revealed a small cell carcinoma in one of the tumors and a large cell neuroendocrine carcinoma in the other one. The patient was discharged in good condition and lung inflation in chest X-ray and qualified for adjuvant chemotherapy with a combination of cisplatin and etoposide and the prophylactic cranial irradiation. Very important issues, having impact on outcome of patients with multiple lung tumours is differentiation whether the lesions are metastases or synchronous primary lung tumors and the optimal management of these patients.
authors.affiliation: Chair and Department of Thoracic Surgery, Faculty of Medicine and Dentistry Medical University of Silesia, Zabrze, Poland. m.adamek@e.pl.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Rydel
authors.forename: Damian
authors.initials: D
authors.lastname: Czyżewski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Stęplewska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zygo
authors.forename: Mariusz
authors.initials: M
authors.lastname: Adamek
mesh_terms: D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D018288:Carcinoma, Small Cell; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed