title: Cancer Stem Cell Markers Are Associated With Distant Hematogenous Liver Metastases But Not With Peritoneal Carcinomatosis in Colorectal Cancer.
abstract: Although peritoneal carcinomatosis (PC) displays advanced stage in colorectal cancer (CRC), most patients present without distant metastases. To analyze the expression of cancer stem cell markers immunohistochemistry for CD133, CD44 and β-catenin was applied to CRC with exclusive PC, exclusive hepatic metastasis and CRC with combined spread. Expression of cancer stem cell markers correlated with hematogeneous metastases to the liver and was absent in patients with exclusive PC. Thus, expression of cancer stem cell markers correlates with different patterns of metastatic spread in CRC. These data indicate that CRC with exclusive PC lack stem cell features needed for distant dissemination.
authors.affiliation: a Institute of Pathology , Ludwig-Maximilians-Universität München , Munich , Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Neumann
authors.affiliation: b Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery , Medical Center of the University of Munich , Munich , Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Löhrs
authors.affiliation: b Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery , Medical Center of the University of Munich , Munich , Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Albertsmeier
authors.affiliation: a Institute of Pathology , Ludwig-Maximilians-Universität München , Munich , Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Reu
authors.affiliation: b Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery , Medical Center of the University of Munich , Munich , Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Guba
authors.affiliation: b Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery , Medical Center of the University of Munich , Munich , Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Werner
authors.affiliation: a Institute of Pathology , Ludwig-Maximilians-Universität München , Munich , Germany.|c German Cancer Consortium (DKTK) , Heidelberg , Germany.|d German Cancer Research Center (DKFZ) , Heidelberg , Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kirchner
authors.affiliation: b Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery , Medical Center of the University of Munich , Munich , Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Angele
mesh_terms: D000071916:AC133 Antigen; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010455:Peptides / Q000032:analysis; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary*; D051176:beta Catenin / Q000032:analysis
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C497483:CD44 protein, human; C495270:CTNNB1 protein, human; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C000606023:PROM1 protein, human; D010455:Peptides; D051176:beta Catenin
keywords: CD133; CD44; Colorectal cancer; Liver metastasis; Peritoneal carcinomatosis; β-catenin