title: E-selectin and P-selectin expression in endothelium of leprosy skin lesions.
abstract: Leprosy is an infectious-contagious disease whose clinical evolution depends on the immune response pattern of the host. Adhesion molecules and leukocyte migration from blood to tissue are of the utmost importance for the recognition and elimination of infectious pathogens. Selectins are transmembrane glycoproteins that share a similar structural organization and can be divided into three types according to their site of expression. The biopsies were cut into 5μm thick sections and submitted to immunohistochemistry using antibodies against E-selectin and P-selectin. The number of E-selectin-positive cells was significantly higher in the tuberculoid form than in the lepromatous form. The immunostaining pattern of P-selectin differed from that of E-selectin. Analysis showed a larger number of endothelial cells expressing CD62P in the lepromatous form compared to the tuberculoid form. The presence of these adhesins in the endothelium contributing to or impairing the recruitment of immune cells to inflamed tissue and consequently influences the pattern of immune response and the clinical presentation of the disease.
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Juarez de
authors.initials: Jd
authors.lastname: Souza
authors.affiliation: Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
authors.forename: Jorge Rodrigues de
authors.initials: JR
authors.lastname: Sousa
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Kelly Emi
authors.initials: KE
authors.lastname: Hirai
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Luciana Mota
authors.initials: LM
authors.lastname: Silva
authors.affiliation: Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
authors.forename: Hellen Thais
authors.initials: HT
authors.lastname: Fuzii
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Leonidas Braga
authors.initials: LB
authors.lastname: Dias
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Francisca Regina Oliveira
authors.initials: FR
authors.lastname: Carneiro
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
authors.forename: Tinara Leila de Souza
authors.initials: TL
authors.lastname: Aarão
authors.affiliation: Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil. Electronic address: juarez@pesquisador.cnpq.br.
authors.forename: Juarez Antonio Simões
authors.initials: JA
authors.lastname: Quaresma
mesh_terms: D015815:Cell Adhesion Molecules; D019040:E-Selectin / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D015440:Leprosy, Lepromatous / Q000378:metabolism*; D015441:Leprosy, Tuberculoid / Q000378:metabolism*; D019007:P-Selectin / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin; C546936:SELE protein, human; C546937:SELP protein, human
keywords: Endothelium; Immunopathology; Leprosy