title: Diagnostic Significance of Diffusion-Weighted MRI in Renal Cancer.
abstract: BACKGROUND
  This study aimed to investigate whether diffusion-weighted imaging (DWI) could contribute to the discrimination between benign and malignant renal cancer.
  
  
  METHODS
  We searched the PubMed electronic database for eligible studies. STATA 12.0 software was used for statistical analysis. The SMD and 95% CI were calculated.
  
  
  RESULTS
  Decreased ADC signal was seen in all renal cancer patients (cancer tissue versus normal tissue: SMD = 1.63 and 95% CI = 0.96~2.29, P < 0.001; cancer tissue versus benign tissue: SMD = 2.22 and 95% CI = 1.53~2.90 and P < 0.001, resp.). MRI machine type-stratified analysis showed that decreased ADC signal was found by all included MRI machine types in cancer tissues compared with benign cancer tissues (all P < 0.05). The ADC values of renal cancer patients were significantly lower than those of normal controls for all included P values (all P < 0.05), and there was a decreased ADC signal at b-500, b-600, b-1000, b-500, and 1000 gradients compared with benign cancer tissues (all P < 0.05).
  
  
  CONCLUSIONS
  Our study concluded that decreased ADC signal presented in DWI may be essential for the differential diagnosis of renal cancer.
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Li
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Rao
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Shi-Feng
authors.initials: SF
authors.lastname: Tian
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ju
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: An-Liang
authors.initials: AL
authors.lastname: Chen
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Ai-Lian
authors.initials: AL
authors.lastname: Liu
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Jilin University, Changchun, Jilin 130021, China.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography