title: Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission.
abstract: Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, we aimed to define humoral immune correlates of risk of mother-to-child transmission (MTCT) of HIV-1, including responses associated with protection in the RV144 vaccine trial. Eighty-three untreated, HIV-1-transmitting mothers and 165 propensity score-matched nontransmitting mothers were selected from the Women and Infants Transmission Study (WITS) of US nonbreastfeeding, HIV-1-infected mothers. In a multivariable logistic regression model, the magnitude of the maternal IgG responses specific for the third variable loop (V3) of the HIV-1 envelope was predictive of a reduced risk of MTCT. Neutralizing Ab responses against easy-to-neutralize (tier 1) HIV-1 strains also predicted a reduced risk of peripartum transmission in secondary analyses. Moreover, recombinant maternal V3-specific IgG mAbs mediated neutralization of autologous HIV-1 isolates. Thus, common V3-specific Ab responses in maternal plasma predicted a reduced risk of MTCT and mediated autologous virus neutralization, suggesting that boosting these maternal Ab responses may further reduce HIV-1 MTCT.
authors.forename: Sallie R
authors.initials: SR
authors.lastname: Permar
authors.forename: Youyi
authors.initials: Y
authors.lastname: Fong
authors.forename: Nathan
authors.initials: N
authors.lastname: Vandergrift
authors.forename: Genevieve G
authors.initials: GG
authors.lastname: Fouda
authors.forename: Peter
authors.initials: P
authors.lastname: Gilbert
authors.forename: Robert
authors.initials: R
authors.lastname: Parks
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Jaeger
authors.forename: Justin
authors.initials: J
authors.lastname: Pollara
authors.forename: Amanda
authors.initials: A
authors.lastname: Martelli
authors.forename: Brooke E
authors.initials: BE
authors.lastname: Liebl
authors.forename: Krissey
authors.initials: K
authors.lastname: Lloyd
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Yates
authors.forename: R Glenn
authors.initials: RG
authors.lastname: Overman
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.forename: Kaylan
authors.initials: K
authors.lastname: Whitaker
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.forename: Jamie
authors.initials: J
authors.lastname: Pritchett
authors.forename: Erika
authors.initials: E
authors.lastname: Solomon
authors.forename: Emma
authors.initials: E
authors.lastname: Friberg
authors.forename: Dawn J
authors.initials: DJ
authors.lastname: Marshall
authors.forename: John F
authors.initials: JF
authors.lastname: Whitesides
authors.forename: Thaddeus C
authors.initials: TC
authors.lastname: Gurley
authors.forename: Tarra
authors.initials: T
authors.lastname: Von Holle
authors.forename: David R
authors.initials: DR
authors.lastname: Martinez
authors.forename: Fangping
authors.initials: F
authors.lastname: Cai
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Shi-Mao
authors.initials: SM
authors.lastname: Xia
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Lu
authors.forename: Raul
authors.initials: R
authors.lastname: Louzao
authors.forename: Samantha
authors.initials: S
authors.lastname: Wilkes
authors.forename: Saheli
authors.initials: S
authors.lastname: Datta
authors.forename: Marcella
authors.initials: M
authors.lastname: Sarzotti-Kelsoe
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Liao
authors.forename: Guido
authors.initials: G
authors.lastname: Ferrari
authors.forename: S Munir
authors.initials: SM
authors.lastname: Alam
authors.forename: David C
authors.initials: DC
authors.lastname: Montefiori
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Denny
authors.forename: M Anthony
authors.initials: MA
authors.lastname: Moody
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Tomaras
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
mesh_terms: D016915:AIDS Vaccines / Q000494:pharmacology; D057134:Antibodies, Neutralizing / Q000097:blood; D000918:Antibody Specificity; D000956:Antigens, Viral; D015331:Cohort Studies; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000635:transmission*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D016015:Logistic Models; D015999:Multivariate Analysis; D010446:Peptide Fragments / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D012307:Risk Factors
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D000956:Antigens, Viral; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D007074:Immunoglobulin G; D010446:Peptide Fragments