title: Overexpressing components of the nuclear transport apparatus causes severe growth symptoms in tobacco leaves.
abstract: Regulating nucleo-cytoplasmic transport of RNA and protein is a key cellular control point. Perturbing the function of plant nuclear transport components can cause significant developmental defects and in this report we add an important line to this evidence. Overexpression of AtRAN1 or AtNUP62 in Nicotiana benthamiana causes significant damage to leaf tissue. This demonstrates that the precise control of nuclear transport is an important aspect of maintaining tissue integrity.
authors.affiliation: a Institute of Integrative Biology; University of Liverpool ; Liverpool , United Kingdom.
authors.forename: Clare
authors.initials: C
authors.lastname: Kemp
authors.forename: Alex
authors.initials: A
authors.lastname: Coleman
authors.forename: Graeme
authors.initials: G
authors.lastname: Wells
authors.forename: Geraint
authors.initials: G
authors.lastname: Parry
mesh_terms: D021581:Active Transport, Cell Nucleus; D029681:Arabidopsis Proteins / Q000378:metabolism; D027682:Cation Transport Proteins / Q000378:metabolism; D000079922:Copper Transport Proteins; D008562:Membrane Glycoproteins / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D018515:Plant Leaves / Q000254:growth & development; D030821:Plants, Genetically Modified; D016601:RNA-Binding Proteins; D014026:Nicotiana / Q000254:growth & development / Q000378:metabolism*; D020931:ran GTP-Binding Protein
chemical_list: D029681:Arabidopsis Proteins; C490178:At5g20010 protein, Arabidopsis; D027682:Cation Transport Proteins; D000079922:Copper Transport Proteins; D008562:Membrane Glycoproteins; D028861:Nuclear Pore Complex Proteins; D016601:RNA-Binding Proteins; C049312:nuclear pore protein p62; D020931:ran GTP-Binding Protein
keywords: NUP62; RAN1; nicotiana benthamiana; nuclear transport; nucleoporin; nucleus