title: Efficacy and safety of misoprostol compared with the dinoprostone for labor induction at term: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy and safety of intravaginal misoprostol and the dinoprostone vaginal insert for labor induction at term.
  
  
  METHODS
  PubMed, EMBASE, MEDLINE, CNKI, EBSCO and the Cochrane Library were searched for articles published in English language from 2000 to 2014, Using the keywords misoprostol, dinoprostone, labor induction.
  
  
  RESULTS
  Eight of 436 studies (1669 women) identified met the criteria for meta-analysis. We assigned a quality rating to each included article. The use of misoprostol showed less oxytocin augmentation when compared with dinoprostone (RR = 0.78, 95% CI = 0.67-0.90). There was no difference in the risk of tachysystole (RR = 1.18, 95% CI = 0.78-1.79), uterine hyperstimulation (RR = 1.24, 95% CI = 0.75-2.06), vaginal delivery within 24 h (RR = 1.10, 95% CI = 1.00-1.20), cesarean delivery (RR = 0.84, 95% CI = 0.56-1.24), Neonatal Intensive Care Unit admission (RR = 0.86, 95% CI = 0.58-1.28), Apgar scores <7 in 5 min (RR = 1.18, 95% CI = 0.39-3.63) between misoprostol and dinoprostone.
  
  
  CONCLUSIONS
  Misoprostol compared with dinoprostone appears to show less oxytocin augmentation for labor induction at term. The other outcomes of both drugs were similar. However, these findings were based on small-scale trials. Further studies assessing the effectiveness and safety of misoprostol and dinoprostone in selected groups of patients are warranted.
authors.affiliation: a Department of Obstetric , The People's Liberation Army 174th Clinical College of Anhui Medical University , Xiamen , P.R. China .
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.affiliation: b Department of Ob/Gyn and Neonatal and Reproductive Medicine , The People's Liberation Army 174th Hospital , Xiamen , P.R. China .|c Medical College, Xiamen University, Xiang'an , Xiamen , P.R. China , and.
authors.forename: Jianlan
authors.initials: J
authors.lastname: Zheng
authors.affiliation: d The People's Liberation Army 174th Hospital , Xiamen , P.R. China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Wang
authors.affiliation: d The People's Liberation Army 174th Hospital , Xiamen , P.R. China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Fu
authors.affiliation: a Department of Obstetric , The People's Liberation Army 174th Clinical College of Anhui Medical University , Xiamen , P.R. China .
authors.forename: Li
authors.initials: L
authors.lastname: Hou
mesh_terms: D015232:Dinoprostone; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol; D010120:Oxytocics; D010121:Oxytocin / Q000032:analysis; D011247:Pregnancy; D047929:Term Birth
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin; D015232:Dinoprostone
keywords: Dinoprostone; labor induction; misoprostol