title: Are there any causes for increased thyroid volume in women with prolactinoma?
abstract: OBJECTIVE
  The aim of this study was to evaluate thyroid volume in women with prolactinoma and investigate the relationship between anabolic hormones [insulin, insulin like growth factor (IGF-1), estrogen] and thyroid volume in the patients.
  
  
  METHODS
  Sixty-three euthyroid women with prolactinoma and 60 healthy euthyroid women were included. Serum prolactin (PRL), thyroid-stimulating hormone (TSH), thyroxine (free T4), free tri-iodothyronine (free T3), insulin resistance (IR) which was estimated by the homeostasis model assessment, thyroidal microsome (anti-TPO), antithyroglobulin antibodies (TgAb), estradiol (E2), and insulin like growth factor (IGF-1) were evaluated, and thyroid volume was calculated by B-mode doppler USG.
  
  
  RESULTS
  The mean thyroid volume was significantly higher in women with prolactinoma (82.5±15.1mL) than in healthy women (76±15.1mL)(P=0.014), but no correlation was found between thyroid volume and serum PRL levels (P=0.967). There were also no differences between thyroid volume, anabolic hormones (E2, IGF-1), and insulin resistance in women with prolactinoma (P=0.776, P=0.786, P=0.647, respectively).
  
  
  CONCLUSIONS
  Our study did not show an association between anabolic hormones and increased thyroid volume in women with prolactinoma.
authors.affiliation: Department of Endocrinology and Metabolism Disease, Darica Farabi State Hospital, Darica, Kocaeli, Turkey. Electronic address: bercemay@gmail.com.
authors.forename: Berçem Ayçiçek
authors.initials: BA
authors.lastname: Doğan
authors.affiliation: Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Tuğba
authors.initials: T
authors.lastname: Taşcı
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes, Endocrine and Obesity Branch, National Institutes of Health, 20892 Bethesda, MD, USA.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Arduç
authors.affiliation: Endocrinology and Metabolism Disease, Dicle University, Diyarbakır, Turkey.
authors.forename: Mazhar
authors.initials: M
authors.lastname: Müslüm Tuna
authors.affiliation: Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.affiliation: Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey; Endocrinology and Metabolism Disease, Hitit university, Çorum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Güler
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000473:pathology*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D014284:Triiodothyronine; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013972:Thyrotropin; D013974:Thyroxine
keywords: Anabolic hormones; Hormones anabolisantes; Prolactinoma; Prolactinome; Thyroid volume; Volume thyroïdien