title: Long-chain n-3 PUFAs from fish oil enhance resting state brain glucose utilization and reduce anxiety in an adult nonhuman primate, the grey mouse lemur.
abstract: Decreased brain content of DHA, the most abundant long-chain n-3 polyunsaturated fatty acid (n-3 LCPUFA) in the brain, is accompanied by severe neurosensorial impairments linked to impaired neurotransmission and impaired brain glucose utilization. In the present study, we hypothesized that increasing n-3 LCPUFA intake at an early age may help to prevent or correct the glucose hypometabolism observed during aging and age-related cognitive decline. The effects of 12 months' supplementation with n-3 LCPUFA on brain glucose utilization assessed by positron emission tomography was tested in young adult mouse lemurs (Microcebus murinus). Cognitive function was tested in parallel in the same animals. Lemurs supplemented with n-3 LCPUFA had higher brain glucose uptake and cerebral metabolic rate of glucose compared with controls in all brain regions. The n-3 LCPUFA-supplemented animals also had higher exploratory activity in an open-field task and lower evidence of anxiety in the Barnes maze. Our results demonstrate for the first time in a nonhuman primate that n-3 LCPUFA supplementation increases brain glucose uptake and metabolism and concomitantly reduces anxiety.
authors.affiliation: Mécanismes Adaptatifs et Evolution, UMR 7179 CNRS-MNHN, Brunoy, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.affiliation: Mécanismes Adaptatifs et Evolution, UMR 7179 CNRS-MNHN, Brunoy, France CNRS, URA CEA CNRS 2210, Fontenay-aux-Roses, France.
authors.forename: Olène
authors.initials: O
authors.lastname: Dorieux
authors.affiliation: Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Christian-Alexandre
authors.initials: CA
authors.lastname: Castellano
authors.affiliation: Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Etienne
authors.initials: E
authors.lastname: Croteau
authors.affiliation: Mécanismes Adaptatifs et Evolution, UMR 7179 CNRS-MNHN, Brunoy, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Masson
authors.affiliation: CNRS, URA CEA CNRS 2210, Fontenay-aux-Roses, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Guillermier
authors.affiliation: Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Nadja
authors.initials: N
authors.lastname: Van Camp
authors.affiliation: LZ, Versailles, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guesnet
authors.affiliation: Microbiologie de l'Alimentation au Service de la Santé Humaine, INRA de Jouy en Josas, Jouy en Josas Cedex, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Alessandri
authors.affiliation: Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Cunnane
authors.affiliation: CNRS, URA CEA CNRS 2210, Fontenay-aux-Roses, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Dhenain
authors.affiliation: Mécanismes Adaptatifs et Evolution, UMR 7179 CNRS-MNHN, Brunoy, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001481:Basal Metabolism / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism* / Q000503:physiopathology; D016565:Cheirogaleidae; D019587:Dietary Supplements; D005106:Exploratory Behavior / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D005395:Fish Oils / Q000737:chemistry*; D005947:Glucose / Q000378:metabolism*; D008297:Male; D065852:Spatial Memory / Q000187:drug effects
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D005947:Glucose
keywords: brain glucose hypometabolism; long-chain n-3 polyunsaturated fatty acids; positron emission tomography imaging