title: Highly enantioselective asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones.
abstract: A mild catalyst system for the synthesis of chiral amino alcohols via asymmetric transfer hydrogenation (ATH) of α-phthalimide ketones has been developed by using a chiral Ru-TsDPEN complex as the catalyst in DMF/MeOH at 40 °C. The reaction exhibits high reaction activity and excellent enantioselectivity where up to 96% yield and 99% ee of the product were obtained.
authors.affiliation: Department of Chemistry, Xuzhou Medical College, Jiangsu, Xuzhou 221004, P.R. China. xuzhou@xzmc.edu.cn.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Songlei
authors.initials: S
authors.lastname: Zhu
authors.forename: Rongli
authors.initials: R
authors.lastname: Zhang
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry; D005029:Ethylenediamines / Q000737:chemistry; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010797:Phthalimides / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D005029:Ethylenediamines; D007659:Ketones; D009942:Organometallic Compounds; D010797:Phthalimides; D012997:Solvents; C520782:ruthenium-(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine; C037431:phthalimide