title: Screening of patients with bronchopulmonary diseases using methods of infrared laser photoacoustic spectroscopy and principal component analysis.
abstract: A human exhaled air analysis by means of infrared (IR) laser photoacoustic spectroscopy is presented. Eleven healthy nonsmoking volunteers (control group) and seven patients with chronic obstructive pulmonary disease (COPD, target group) were involved in the study. The principal component analysis method was used to select the most informative ranges of the absorption spectra of patients' exhaled air in terms of the separation of the studied groups. It is shown that the data of the profiles of exhaled air absorption spectrum in the informative ranges allow identifying COPD patients in comparison to the control group.
authors.affiliation: Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, RussiabTomsk State University, University Administration, 36 Lenina Avenue, Tomsk 634050, Russia.
authors.forename: Yury V
authors.initials: YV
authors.lastname: Kistenev
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Karapuzikov
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Nadezhda Yu
authors.initials: NY
authors.lastname: Kostyukova
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Marina K
authors.initials: MK
authors.lastname: Starikova
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Boyko
authors.affiliation: Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, Russia.
authors.forename: Ekaterina B
authors.initials: EB
authors.lastname: Bukreeva
authors.affiliation: Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, Russia.
authors.forename: Anna A
authors.initials: AA
authors.lastname: Bulanova
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, RussiadNovosibirsk State University, 2 Pirogova Street, Novosibirsk 630090, Russia.
authors.forename: Dmitry B
authors.initials: DB
authors.lastname: Kolker
authors.affiliation: Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, Russia.
authors.forename: Dmitry A
authors.initials: DA
authors.lastname: Kuzmin
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Zenov
authors.affiliation: Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia.
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Karapuzikov
mesh_terms: D000328:Adult; D001944:Breath Tests / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D061088:Photoacoustic Techniques / Q000379:methods*; D025341:Principal Component Analysis / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000378:metabolism; D013055:Spectrophotometry, Infrared / Q000379:methods*; D055549:Volatile Organic Compounds / Q000032:analysis / Q000737:chemistry; D055815:Young Adult
chemical_list: D055549:Volatile Organic Compounds