title: Assessment of Apoptotic Activity Dysregulation and Oxidative Stress in the Development of Epithelial Ovarian Cancer: A Case-Controlled Descriptive Analysis.
abstract: OBJECTIVE
  In the present study, we aimed to assess whether oxidative stress and apoptotic activity play a role in the development of epithelial ovarian cancer (EOC).
  
  
  METHODS
  The study group included patients with EOC (n = 26) and benign ovarian tumour (BOT) (n = 25), while 30 healthy women were employed as a control group. Venous blood samples were drawn to evaluate oxidative stress parameters and serum M30/M65 antigen levels before surgery. In addition, blood samples were taken for the second time on postoperative day 8 to analyse whether the postoperative tumour load was decreased.
  
  
  RESULTS
  When the groups were assessed regarding oxidative stress, the highest values were detected in patients with EOC. Serum M30/M65 levels were found to be higher in patients with EOC when compared to the other groups (p < 0.001). A significant decrease was determined in the M30/M65 levels of serum samples taken on postoperative day 8 from the patients in the EOC and BOT groups (p < 0.001).
  
  
  CONCLUSIONS
  Our results suggest that dysregulation of apoptotic activity could be effective in the development of ovarian tumoural tissue, whereas oxidative stress could be effective in malignant transformation.
authors.affiliation: Department of Gynaecology and Obstetrics, Harran University, Sanliurfa, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Incebiyik
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.forename: Nese Gul
authors.initials: NG
authors.lastname: Hilali
authors.forename: Aysun
authors.initials: A
authors.lastname: Camuzcuoglu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Seker
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053538:Keratin-18 / Q000097:blood*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood*; D010051:Ovarian Neoplasms / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D053538:Keratin-18