title: Heterogeneous bovine acellular dermal matrix for mucosal repair in reconstructive surgery for laryngeal and hypopharyngeal carcinoma.
abstract: BACKGROUND
  We performed this study to explore the clinical effects of a heterogeneous bovine acellular dermal matrix (ADM) used for repairing mucosal defects in reconstructive surgery following resection for laryngeal and hypopharyngeal carcinoma.
  
  
  METHODS
  A summary analysis was carried out on the surgical data of 93 patients who underwent reconstructive surgery using a heterogeneous bovine ADM following resection of laryngeal and hypopharyngeal carcinoma. The patients underwent an electronic laryngoscope review.
  
  
  RESULTS
  After 3-6 months, the repaired mucosa had replaced the mucosal defects in 88 patients who had undergone stage I reconstruction, recovering local function. Due to infection, 3 patients had a laryngeal fistula and 2 patients had a pharyngeal fistula; the fistula incidence rate was 5.4%. 86 patients underwent successful tracheal extubation (extubation rate, 92.5%). The duration from tracheotomy to extubation was 8-31 days; the average duration was 10.4 days.
  
  
  CONCLUSIONS
  The heterogeneous bovine ADM is a new, safe, and effective material for reconstructive surgery. In patients with large mucosal defects, it avoids the trauma caused by flap repair.
authors.affiliation: Department of Otorhinolaryngology, Head & Neck Surgery, Xiangya Hospital of Central South University, Changsha, China.
authors.forename: Jian
authors.initials: J
authors.lastname: He
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Liao
authors.forename: Huatao
authors.initials: H
authors.lastname: Quan
authors.forename: Jing
authors.initials: J
authors.lastname: Kang
authors.forename: Yaoyun
authors.initials: Y
authors.lastname: Tang
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002417:Cattle; D044964:Cervicoplasty / Q000379:methods*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000601:surgery*; D007820:Laryngeal Mucosa / Q000601:surgery*; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged