title: The effects of a low-salt diet on the efficacy of different antihypertensive drug regimens.
abstract: The objective of this study was to compare the antihypertensive effects of 3 types of antihypertensive drug regimens between different salt intake levels. The 180 patients with mild to moderate primary hypertension participating in this randomized, controlled clinical trial were randomly allocated to a low-salt diet (LSD) group or a non-low-salt diet (NLSD) group. Each group included 3 subgroups: a losartan 100 mg subgroup, a losartan 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg subgroup, and an irbesartan 150 mg/HCTZ 12.5 mg subgroup. The LSD group received a diet in which the sodium content was strictly controlled (2.3 g/day). After 2 months, the office blood pressure (BP), the 24-hour mean BP, and the morning BP were significantly reduced (P ≤ .01) in each group. No significant differences were observed between the 3 LSD subgroups (P > .05). In the NLSD group, the losartan 50 mg/HCTZ 12.5 mg subgroup, and the irbesartan 150 mg/HCTZ 12.5 mg subgroup exhibited identical antihypertensive efficacy (P > .05), and these groups were significantly different from the losartan 100 mg subgroup(P ≤ .05). The BP of the patients who received the LSD was further decreased compared with those who received the NLSD (P ≤ .05). Therefore, we concluded that this LSD exerts synergistic BP-reducing effects.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Chongqing Red Cross Hospital, Chongqing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Qiu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Du
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Song-Bai
authors.initials: SB
authors.lastname: Deng
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: She
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001713:Biphenyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004039:Diet, Sodium-Restricted; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D000077405:Irbesartan; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D013777:Tetrazoles; D006852:Hydrochlorothiazide; D000077405:Irbesartan; D019808:Losartan
keywords: hydrochlorothiazide; irbesartan; losartan; primary hypertension; salt