title: Study on the antibacterial mechanism of copper ion- and neodymium ion-modified α-zirconium phosphate with better antibacterial activity and lower cytotoxicity.
abstract: To improve the antibacterial activity of Cu(2+), a series of Cu(2+) and/or Nd(3+)-modified layered α-zirconium phosphate (ZrP) was prepared and characterized, and the antibacterial activities of the prepared Cu(2+) and/or Nd(3+)-modified ZrP on Gram-negative Escherichia coli were investigated. The results showed that the basal spacing of ZrP was not obviously affected by the incorporation of Cu(2+), but the basal spacing of the modified ZrP changed into an amorphous state with increasing additions of Nd(3+). An antibacterial mechanism showed that Cu(2+) and Nd(3+) could enter into E. coli cells, leading to changes in ion concentrations and leakage of DNA, RNA and protein. The Cu(2+)- and Nd(3+)-modified ZrP, combining the advantages of Cu(2+) and Nd(3+), displayed excellent additive antibacterial activity and lower cytotoxicity, suggesting the great potential application as an antibacterial powder for microbial control.
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, PR China; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors.forename: Jinglin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Xiaoyin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Hongxi
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Wen
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, PR China. Electronic address: tanshaozao@163.com.
authors.forename: Shaozao
authors.initials: S
authors.lastname: Tan
authors.affiliation: Department of Light Chemical Engineering, Guangdong Polytechnic, Foshan 528041, PR China. Electronic address: angelwu2006@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009354:Neodymium / Q000737:chemistry*; D014961:X-Ray Diffraction; D015040:Zirconium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C027006:zirconium phosphate; D009354:Neodymium; D003300:Copper; D015040:Zirconium
keywords: Antibacterial mechanism; Copper ion; Cytotoxicity; Neodymium ion; α-Zirconium phosphate