title: Henoch-Schönlein purpura in a renal transplant recipient with prior IgA nephropathy following influenza vaccination.
abstract: Henoch-Schönlein purpura (HSP) is a systemic small-vessel leucocytoclastic vasculitis with deposition of immune complexes containing Immunoglobulin A (IgA). IgA Nephropathy (IgAN) is a glomerulonephritis caused by mesangial deposition of IgA. The onset of HSP, but not IgAN, has been linked to influenza vaccination. We report the first case of HSP with glomerular involvement, in a renal transplant recipient following influenza vaccination. The patient had prior end-stage renal failure (ESRF) secondary to IgAN, without clinical evidence of IgAN recurrence after transplantation. This is of clinical relevance as influenza vaccination is regarded safe, effective, and recommended after renal transplantation. Nephrologists should be aware of the potential for influenza vaccination to have adverse effects in renal transplant recipients, especially if the primary renal disease is HSP or IgAN.
authors.affiliation: Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand.
authors.forename: Andrew
authors.initials: A
authors.lastname: McNally
authors.affiliation: Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand.
authors.forename: David
authors.initials: D
authors.lastname: McGregor
authors.affiliation: Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand.
authors.forename: Martin
authors.initials: M
authors.lastname: Searle
authors.affiliation: Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand.
authors.forename: John
authors.initials: J
authors.lastname: Irvine
authors.affiliation: Department of Nephrology , Christchurch Hospital, Canterbury District Health Board , Christchurch , New Zealand.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Cross
keywords: Henoch–Schönlein purpura (HSP); Immunoglobulin A nephropathy (IgAN); influenza vaccination; renal transplant