title: Hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus.
abstract: OBJECTIVE
  The primary objective of the treatment of diabetes mellitus is the attainment of glycemic control. Hyperglycemia increases oxidative stress which contributes to the progression of diabetic complications. Thus, the purpose of this study was to investigate the hypoglycemic and antioxidant effects of Daraesoon (Actinidia arguta shoot) in animal models of diabetes mellitus.
  
  
  METHODS
  Rats with streptozotocin-induced diabetes received an oral administration of a starch solution (1 g/kg) either with or without a 70% ethanol extract of Daraesoon (400 mg/kg) or acarbose (40 mg/kg) after an overnight fast and their postprandial blood glucose levels were measured. Five-week-old C57BL/6J mice were fed either a basal or high-fat/high-sucrose (HFHS) diet with or without Daraesoon extract (0.4%) or acarbose (0.04%) for 12 weeks after 1 week of adaptation to determine the effects of the chronic consumption of Daraesoon on fasting hyperglycemia and antioxidant status.
  
  
  RESULTS
  Compared to the control group, rats that received Daraesoon extract (400 mg/kg) or acarbose (40 mg/kg) exhibited a significant reduction in the area under the postprandial glucose response curve after the oral ingestion of starch. Additionally, the long-term consumption of Daraesoon extract or acarbose significantly decreased serum glucose and insulin levels as well as small intestinal maltase activity in HFHS-fed mice. Furthermore, the consumption of Daraesoon extract significantly reduced thiobarbituric acid reactive substances and increased glutathione levels in the livers of HFHS-fed mice compared to HFHS-fed mice that did not ingest Daraesoon.
  
  
  CONCLUSIONS
  Daraesoon effectively suppressed postprandial hyperglycemia via the inhibition of α-glucosidase in STZ-induced diabetic rats. Chronic consumption of Daraesoon alleviated fasting hyperglycemia and oxidative stress in mice fed a HFHS diet.
authors.affiliation: Department of Smart Food and Drugs, School of Food and Life Science, Inje University, 197 Inje-ro, Gimhae, 621-749, Korea.
authors.forename: Ah-Yeon
authors.initials: AY
authors.lastname: Lee
authors.affiliation: Food and Nutrition Research Team, Division of Research and Development, Hurom Co., Ltd., 158 Golden root-ro, Gimhae, Gyungnam, 621-844, Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kang
authors.affiliation: Department of Food and Nutrition, Inha University, 100 Inha-ro, Incheon, 402-823, Korea.
authors.forename: Eunok
authors.initials: E
authors.lastname: Choe
authors.affiliation: Department of Smart Food and Drugs, School of Food and Life Science, Inje University, 197 Inje-ro, Gimhae, 621-749, Korea.
authors.forename: Jung-In
authors.initials: JI
authors.lastname: Kim
keywords: Actinidia arguta shoot; antioxidant; diabetes; glucose; α-glucosidase