title: Safety and Efficacy of Bimatoprost for Eyelash Growth in Postchemotherapy Subjects.
abstract: OBJECTIVE
  To evaluate long-term efficacy and safety of bimatoprost for treatment of chemotherapy-induced eyelash hypotrichosis.
  
  
  METHODS
  One-year, multicenter, double-masked, parallel-group study.
  
  
  METHODS
  Twenty-one centers in the United States and one center in the United Kingdom.
  
  
  METHODS
  This study randomized (3:1) 130 subjects to bimatoprost 0.03% or vehicle applied topically to upper eyelid margins for six months. All subjects used bimatoprost for a second six months.
  
  
  METHODS
  Responders for the primary composite end point achieved ≥1-grade improvement in Global Eyelash Assessment score and ≥3-point improvement in Confidence, Attractiveness, and Professionalism domain score of the Eyelash Satisfaction Questionnaire at Month 4. Secondary assessments included eyelash length, thickness, and darkness, using digital image analysis.
  
  
  RESULTS
  The responder rate was significantly higher with bimatoprost versus vehicle at Month 4 (37.5% vs. 18.2%; p=0.041) and Month 6 (46.9% vs. 18.2%; p=0.004). Significant improvements favoring bimatoprost occurred in eyelash length (p=0.008), thickness (p<0.001), or darkness (p=0.029) at Month 4, with similar results at Month 6 (p<0.001, length; p<0.001, thickness; p=0.002, darkness). Responder rates reached 61.5 percent at Month 12 for subjects continuing bimatoprost and 67.6 percent for those switched from vehicle to bimatoprost. Conjunctival hyperemia (16.7%) and punctate keratitis (9.4%) were the most common adverse events.
  
  
  CONCLUSIONS
  Bimatoprost provides rapid eyelash recovery, whether started shortly after chemotherapy (4 to 12 weeks) or delayed for six months, with minimal adverse events.
  
  
  BACKGROUND
  NCT00907426.
authors.affiliation: David Wirta and Associates, Newport Beach, California.
authors.forename: David
authors.initials: D
authors.lastname: Wirta
authors.affiliation: Baumann Cosmetic and Research Institute, Miami, Florida.
authors.forename: Leslie
authors.initials: L
authors.lastname: Baumann
authors.affiliation: Suzanne Bruce and Associates, PA, Houston, Texas.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Bruce
authors.affiliation: Allergan, Inc., Irvine, California.
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Ahluwalia
authors.affiliation: Allergan, Inc., Irvine, California.
authors.forename: Emily
authors.initials: E
authors.lastname: Weng
authors.affiliation: Allergan, Inc., Irvine, California.
authors.forename: Selena
authors.initials: S
authors.lastname: Daniels