title: Antimicrobial Efficacy of Extemporaneously Prepared Herbal Mouthwashes.
abstract: Natural products like plants and its components have been in use for treatment and cure of diseases all around the globe from ancient times much before the discovery of the current modern drugs. These substances from the nature are well known to contain components which have therapeutic properties and can also behave as precursors for the synthesis of potential drugs. The beneficial results from herbal drugs are well reported where their popularity in usage has increased across the globe. Subsequently developing countries are now recognizing the many positive advantages from their use which has engaged the expansion of R & D from herbal research. The flow on effect from this expansion has increased the awareness to develop new herbal products and the processes, throughout the entire world. Mouth washes and mouth rinses which have plant oils, plant components or extracts have generated particular attention. High prevalence of gingival inflammation and periodontal diseases, suggests majority of the patients practice inadequate plaque control. Of the currently available mouthwashes in the market, Chlorhexidine gluconate (CHX) has been investigated on a larger scale with much detail. CHX is associated with side effects like staining of teeth when used daily as well as the bitter taste of the mouthwash which leads to patient incompliance. The present research encompasses the antibacterial activity of extemporaneously prepared herbal mouthwash using natural herbs and therefore allows for the potential commercialization with in the herbal and pharmaceutical industries. Also, the present research article reviewed details of various existing patents of herbal mouthwashes which shows the trend of existing market and significance of emerging mouthwashes in both pharmaceutical and herbal industries. The antimicrobial activity of prepared mouthwashes was found to be effective against various strains of bacteria. It also suggests that the prepared herbal mouthwashes may provide an alternative to those containing chemical entities, with enhanced antimicrobial properties and better patient compliance.
authors.forename: Kamal
authors.initials: K
authors.lastname: Dua
authors.forename: Ravi
authors.initials: R
authors.lastname: Sheshala
authors.forename: Haider A
authors.initials: HA
authors.lastname: Al-Waeli
authors.forename: Gauarv
authors.initials: G
authors.lastname: Gupta
authors.affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. Dinesh_Kumar@imu.edu.my.
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Chellappan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D004059:Diffusion of Innovation; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D009067:Mouthwashes / Q000494:pharmacology*; D010330:Patents as Topic; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D028321:Plant Preparations; C010882:chlorhexidine gluconate; D002710:Chlorhexidine