title: Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp(3))-H Functionalization.
abstract: Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C(sp(3))-H functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Niu
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
authors.forename: Wannian
authors.initials: W
authors.lastname: Zhao
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
authors.forename: Yingcai
authors.initials: Y
authors.lastname: Ding
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Bian
authors.affiliation: ‡Mississippi State University, Mississippi State, Mississippi 39762, United States.
authors.forename: Charles U
authors.initials: CU
authors.lastname: Pittman
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu 212013, China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhou
authors.affiliation: §Department of Chemistry and Chemical Biology, Indiana University Purdue University, Indianapolis, Indiana 46202, United States.
authors.forename: Haibo
authors.initials: H
authors.lastname: Ge
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D055808:Drug Discovery; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D047309:Flavones / Q000737:chemistry*
chemical_list: D003374:Coumarins; D004987:Ethers; D047309:Flavones