title: Clinical Analysis of Adverse Drug Reactions between Vincristine and Triazoles in Children with Acute Lymphoblastic Leukemia.
abstract: BACKGROUND
  Vincristine (VCR) is a major chemotherapy drug for treatment of childhood acute lymphoblastic leukemia (ALL). Triazole antifungal drugs (AFD) are the main agents for the prevention/treatment of invasive fungal infection (IFI), a common complication during the treatment of ALL. This study investigated the adverse drug reactions (ADRs) between VCR and AFD.
  
  
  METHODS
  A retrospective study was performed on 68 children with ALL (39 boys and 29 girls, median age: 5 years) who were treated with VCR chemotherapy (a total of 136 cases, including both induction and reinduction phases) from January 2012 to December 2013 in our hospital. These cases were divided into 4 groups: the control group without AFD prevention/treatment (n=44), the Itra group receiving itraconazole oral solution (n=44), the Fluc group receiving intravenous fluconazole (n=42), and the Vori group receiving voriconazole oral tablets (n=6). The ADRs in each group was recorded and compared.
  
  
  RESULTS
  The incidence of ADRs in the Itra and Vori groups were significantly higher compared with the Fluc and the control group (P<0.05). The incidence of ADRs in the Itra group was significantly higher than that in the Vori group, whereas there was no difference in the incidence between the Fluc and control group.
  
  
  CONCLUSIONS
  Given the lower incidence of ADRs between VCR and fluconazole compared with voriconazole or itraconazole, it is relatively safer to use fluconazole in ALL patients receiving VCR chemotherapy. The occurrence of ADRs should be closely monitored when triazoles must be administered concomitantly with VCR.
authors.affiliation: Department of Pediatric Hematology and Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Lihua
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pediatric Hematology and Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Lihua
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Pediatric Hematology and Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Xinxin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pediatric Hematology and Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Pediatric Hematology and Oncology, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015725:Fluconazole / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use; D065819:Voriconazole / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D017964:Itraconazole; D014750:Vincristine; D015725:Fluconazole; D065819:Voriconazole