title: An efficient synthesis and in vitro antibacterial evaluation of ruthenium-quinolinol complexes.
abstract: A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy & time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence.
authors.affiliation: Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
authors.forename: Mahima
authors.initials: M
authors.lastname: Malipeddi
authors.affiliation: Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
authors.forename: Chirag
authors.initials: C
authors.lastname: Lakhani
authors.affiliation: Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India.
authors.forename: Mohit
authors.initials: M
authors.lastname: Chhabra
authors.affiliation: Pharmaceutical Chemistry Division, School of Advance Sciences, VIT University, Vellore 632014, Tamilnadu, India. Electronic address: priyankar.paira@vit.ac.in.
authors.forename: Priyankar
authors.initials: P
authors.lastname: Paira
authors.affiliation: School of Biosciences and Technology, VIT University, Vellore 632014, Tamilnadu, India. Electronic address: rvidya@vit.ac.in.
authors.forename: R
authors.initials: R
authors.lastname: Vidya
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D006912:Hydroxyquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D006912:Hydroxyquinolines; D012428:Ruthenium
keywords: Antibacterial assay; Fluorescent complex; Ruthenium–quinolinol complex