title: Liposomes incorporating cyclodextrin-drug inclusion complexes: Current state of knowledge.
abstract: Cyclodextrins (CDs) are cyclic oligosaccharides, consisting of glucopyranose units, which are able to form host-guest inclusion complexes with lipophilic molecules. The ability of CD to increase drug solubility may be used to increase drug entrapment in the aqueous compartment of liposomes and liposomes can protect CD/drug inclusion complexes until drug release. Liposomes are phospholipid vesicles composed of lipid bilayers enclosing one or more aqueous compartments. They have been widely used as safe and effective carriers for both hydrophilic and lipophilic drugs. However, lipophilic drugs incorporated in the membrane bilayers can be rapidly released, which limits the effectiveness of this drug delivery system. The coupling of both delivery systems by encapsulating CD/drug inclusion complex into liposomes is proposed to circumvent the drawbacks of each separate system. Here, we review the literature regarding the encapsulation of CD/drug inclusion complex into conventional, deformable and double loaded liposomes. The review highlights the characteristics of these systems and presents the advantages and disadvantages of each one.
authors.affiliation: Faculty of Sciences, Bioactive Molecules Research Group, Doctoral School of Sciences and Technologies, Lebanese University, Lebanon.
authors.forename: Riham
authors.initials: R
authors.lastname: Gharib
authors.affiliation: Faculty of Sciences, Bioactive Molecules Research Group, Doctoral School of Sciences and Technologies, Lebanese University, Lebanon. Electronic address: greigegeorges@yahoo.com.
authors.forename: Hélène
authors.initials: H
authors.lastname: Greige-Gerges
authors.affiliation: Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), ULCO, F-59140 Dunkerque, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Fourmentin
authors.affiliation: Laboratoire d'Automatique et de Génie des Procédés, Université Claude Bernard Lyon I, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Charcosset
authors.affiliation: Faculty of Sciences, Bioactive Molecules Research Group, Doctoral School of Sciences and Technologies, Lebanese University, Lebanon.
authors.forename: Lizette
authors.initials: L
authors.lastname: Auezova
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D065546:Drug Liberation; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D003505:Cyclodextrins; D008081:Liposomes; D004364:Pharmaceutical Preparations
keywords: Cyclodextrin; Drug-in-cyclodextrin-in-liposomes; Liposomes