title: Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012.
abstract: The success of treating a wide variety of pediatric diseases with HSCT, hematologic malignancies in particular, has resulted in an increased number of long-term survivors. This study is the first large-scale, multicentre report that describes the evolution of pediatric HSCTs in China during the period of 1998-2012. Of all 1052 patients, 266 cases were treated with autologous HSCs and 786 used allogeneic HSCs. The disease indications for HSCTs mainly included leukemias, lymphoma, solid tumors, and non-malignant disorders. The total number of HSCTs, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five-yr OS and DFS rate of 34.5 ± 14.3% and 20.7 ± 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five-yr OS and DFS rates were 82.8 ± 4% and 80.7 ± 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCTs in China over the past 14 yr.
authors.affiliation: Navy General Hospital, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.affiliation: Shanghai Children's Medical Center, Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Beijing Children's Hospital, Beijing, China.
authors.forename: Maoquan
authors.initials: M
authors.lastname: Qin
authors.affiliation: Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Jianpei
authors.initials: J
authors.lastname: Fang
authors.affiliation: Prince of Wales Hospital, Hong Kong, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Li
authors.affiliation: West China Second University Hospital of Sichuan University, Chengdu, China.
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Guangzhou Women and Children Medical Center, Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Beijing Tongren Hospital, Beijing, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Huang
authors.affiliation: Children's Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
authors.affiliation: Zhe Jiang University School of Medicine Children Hospital, Hangzhou, China.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Soochow University Affiliated Children's Hospital, Suzhou, China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Hu
authors.affiliation: Capital Institute of Pediatics, Beijing, China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Li
authors.affiliation: Wuhan Union Hospital, Wuhan, China.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Navy General Hospital, Beijing, China.
authors.forename: Zuo
authors.initials: Z
authors.lastname: Luan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects; D018572:Disease-Free Survival; D005260:Female; D005843:Geography; D006086:Graft vs Host Disease / Q000453:epidemiology*; D019337:Hematologic Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D061349:Unrelated Donors
keywords: cord blood; graft-versus-host disease; hematopoietic stem cell transplantation; survival