title: The third line of treatment for metastatic prostate cancer patients: Option or strategy?
abstract: New agents for metastatic castration-resistant prostate cancer (CRPC) developed in the past 3 years include cabaziataxel (Cbz), abiraterone acetate (AA) and enzalutamide (E). In this review, the results of clinical studies in which one of these drugs is included as the third line of treatment are discussed. Our review suggests that AA and E have limited activity, while Cbz seems to retain its efficacy. Prospective studies that further examine sequential treatments are warranted.
authors.affiliation: Medical Oncology Unit, University of Siena, Viale Bracci 11, 53100 Siena, Italy. Electronic address: giandomenicoroviello@hotmail.it.
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Roviello
authors.affiliation: Medical Oncology Unit, University of Siena, Viale Bracci 11, 53100 Siena, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Petrioli
authors.affiliation: Medical Oncology Unit, University of Siena, Viale Bracci 11, 53100 Siena, Italy.
authors.forename: Letizia
authors.initials: L
authors.lastname: Laera
authors.affiliation: Medical Oncology Unit, Policlinico Umberto I Hospital, University of Rome, Via del Policlinico 155, 00161 Roma, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Francini
mesh_terms: D000069501:Abiraterone Acetate / Q000627:therapeutic use*; D001549:Benzamides; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009570:Nitriles; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D001549:Benzamides; D009570:Nitriles; D043823:Taxoids; D010669:Phenylthiohydantoin; C552428:cabazitaxel; C540278:enzalutamide; D000069501:Abiraterone Acetate
keywords: Abiraterone acetate; Cabazitaxel; Enzalutamide; Prostate cancer; Sequential therapy