title: Synthesis of (+)-Antroquinonol: An Antihyperglycemic Agent.
abstract: The total synthesis of antroquinonol has been accomplished through Suzuki-Miyaura cross-coupling and Barton-McCombie reaction, and the α,β-unsaturation was achieved through selenylation and oxidation protocols. In vitro and in vivo studies on the glucose-lowering properties of antroquinonol indicate that it is a potential antidiabetic agent.
authors.affiliation: †Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Rohidas S
authors.initials: RS
authors.lastname: Sulake
authors.affiliation: †Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Hsiao-Han
authors.initials: HH
authors.lastname: Lin
authors.affiliation: ‡Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Chia-Yu
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: ‡Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Ching-Feng
authors.initials: CF
authors.lastname: Weng
authors.affiliation: †Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan.
authors.forename: Chinpiao
authors.initials: C
authors.lastname: Chen
mesh_terms: D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D014451:Ubiquinone; C545357:antroquinonol