title: A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers.
abstract: We report here the rational design of the first chlorin-based nanoscale metal-organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient (1)O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.
authors.affiliation: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.
authors.forename: Kuangda
authors.initials: K
authors.lastname: Lu
authors.affiliation: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.
authors.forename: Chunbai
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lin
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003106:Colon / Q000187:drug effects / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use*; D026082:Singlet Oxygen / Q000737:chemistry
chemical_list: D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen; C006969:chlorin