title: Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum).
abstract: Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures were elucidated by analysis of spectroscopic data, as well as by single crystal X-ray analysis. The isolated compounds could not inhibit the apoptosis-regulating enzyme, caspase-3, while three of the compounds (2, 3 and 7) exhibited weak cytotoxic activity.
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. ngokpol@hotmail.com.
authors.forename: Suthatip
authors.initials: S
authors.lastname: Ngokpol
authors.affiliation: Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand. 13020202@cgi.ac.th.
authors.forename: Wittaya
authors.initials: W
authors.lastname: Suwakulsiri
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. sanya@cri.or.th.
authors.forename: Sanya
authors.initials: S
authors.lastname: Sureram
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. kriengsak@cri.or.th.
authors.forename: Kriengsak
authors.initials: K
authors.lastname: Lirdprapamongkol
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. thammarat.aree@gmail.com.
authors.forename: Thammarat
authors.initials: T
authors.lastname: Aree
authors.affiliation: Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. suthep.wiy@mahidol.ac.th.
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. 13020202@cgi.ac.th.|Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand. 13020202@cgi.ac.th.
authors.forename: Chulabhorn
authors.initials: C
authors.lastname: Mahidol
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. 13020202@cgi.ac.th.|Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand. 13020202@cgi.ac.th.|Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10400, Thailand. 13020202@cgi.ac.th.
authors.forename: Somsak
authors.initials: S
authors.lastname: Ruchirawat
authors.affiliation: Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand. prasat@cri.or.th.|Chulabhorn Graduate Institute, Chemical Biology Program, Laksi, Bangkok 10210, Thailand. prasat@cri.or.th.|Center of Excellence on Environmental Health and Toxicology (EHT), CHE, Ministry of Education, Bangkok 10400, Thailand. prasat@cri.or.th.
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010407:Penicillium / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D032901:Talaromyces / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007783:Lactones; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane
keywords: Penicillium minioluteum; Talaromyces minioluteus; caspase-3; cytotoxic activity; drimane; fungal metabolites; marine fungi; sesquiterpene