title: A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.
abstract: OBJECTIVE
  Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations.
  
  
  METHODS
  To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region.
  
  
  RESULTS
  Our data indicated that 18p11.32 (rs1992269, P = 9.77 × 10(-7)), CNTNAP2 (rs802571, P = 1.26 × 10(-6)), and 12q24.23 (rs11613092, P = 6.85 × 10(-6)) were suggestive loci for susceptibility to LOAD.
  
  
  CONCLUSIONS
  We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.
authors.affiliation: aLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama bDepartment of Medicine and Clinical Science cDepartment of Neuropsychiatry dDepartment of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka eDepartment of Psychiatry, Osaka University Graduate School of Medicine, Osaka fNational Hospital Organization Yamato Mental Medical Center, Nara gDepartment of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama hDepartment of Psychiatry, Juntendo University School of Medicine, Tokyo iChoju Medical Institute, Fukushimura Hospital jDepartment of Psychiatry, Fujita Health University School of Medicine, Aichi kDepartment of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ohara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Aoki
authors.forename: Yuta
authors.initials: Y
authors.lastname: Fuyuno
authors.forename: Kyota
authors.initials: K
authors.lastname: Ashikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Morihara
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Kouzin
authors.initials: K
authors.lastname: Kamino
authors.forename: Etsuko
authors.initials: E
authors.lastname: Oshima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Okahisa
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Akatsu
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Akira
authors.initials: A
authors.lastname: Monji
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kiyohara
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Kanba
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002887:Chromosomes, Human, Pair 18; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D007564:Japan; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide
chemical_list: C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins