title: Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia.
abstract: OBJECTIVE
  To study the relationship between thioredoxin-interacting protein (TXNIP) and pancreatic β-cell function in patients with impaired glucose regulation and patients with both impaired glucose regulation and hypertriglyceridemia.
  
  
  METHODS
  We analyzed a population of 90 patients with impaired glucose regulation (IGR), 87 patients with IGR and hypertriglyceridemia, and 90 subjects with normal glucose tolerance (NGT). The levels of plasma TXNIP, a regulator of cellular oxidative stress, were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was used to evaluate insulin resistance in all subjects. In addition, two factors (HOMA for β-cell function [HOMA-β]) and first-phase insulin response [FPIR]) were used to evaluate pancreatic β-cell function. The correlations between the plasma levels of TXNIP, insulin resistance, and islet β-cell dysfunction were analyzed using Pearson's correlation analysis.
  
  
  RESULTS
  Compared with NGT, patients with IGR had significantly lower HOMA-β and FPIR, and higher plasma levels of TXNIP. Compared with the IGR group, patients with both IGR and hypertriglyceridemia had significantly lower HOMA-β and FPIR, and higher plasma levels of TXNIP. There was also a negative correlation between TXNIP and HOMA-β or FPIR, and a positive correlation between TXNIP and HOMA-IR.
  
  
  CONCLUSIONS
  These data showed that the level of TXNIP is increased in patients with IGR and patients with both IGR and hypertriglyceridemia, islet β-cell dysfunction was related to the increased TXNIP in IGR patients.
authors.affiliation: Internal Medicine Teaching and Research Room, Hebei Medical University Shijiazhuang 050017, Hebei, China.
authors.forename: Yong-Cai
authors.initials: YC
authors.lastname: Zhao
authors.affiliation: Department of Laboratory Medicine, University of California San Francisco 94143, CA.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Internal Medicine Teaching and Research Room, Hebei Medical University Shijiazhuang 050017, Hebei, China ; Department of Endocrinology, Hebei General Hospital Hebei Province, China.
authors.forename: Guang-Yao
authors.initials: GY
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Cangzhou Central Hospital Cangzhou 061001, Hebei Province, China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Li
keywords: Impaired glucose regulation; TXNIP; hypertriglyceridemia; β-cell dysfunction