title: Ovarian cancer mortality and industrial pollution.
abstract: We investigated whether there might be excess ovarian cancer mortality among women residing near Spanish industries, according to different categories of industrial groups and toxic substances. An ecologic study was designed to examine ovarian cancer mortality at a municipal level (period 1997-2006). Population exposure to pollution was estimated by means of distance from town to facility. Using Poisson regression models, we assessed the relative risk of dying from ovarian cancer in zones around installations, and analyzed the effect of industrial groups and pollutant substances. Excess ovarian cancer mortality was detected in the vicinity of all sectors combined, and, principally, near refineries, fertilizers plants, glass production, paper production, food/beverage sector, waste treatment plants, pharmaceutical industry and ceramic. Insofar as substances were concerned, statistically significant associations were observed for installations releasing metals and polycyclic aromatic chemicals. These results support that residing near industries could be a risk factor for ovarian cancer mortality.
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IIS Puerta de Hierro, Majadahonda, Spain. Electronic address: jgarcia@isciii.es.
authors.forename: Javier
authors.initials: J
authors.lastname: García-Pérez
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IIS Puerta de Hierro, Majadahonda, Spain. Electronic address: vicarvajal@isciii.es.
authors.forename: Virginia
authors.initials: V
authors.lastname: Lope
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IIS Puerta de Hierro, Majadahonda, Spain. Electronic address: glabente@isciii.es.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: López-Abente
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IIS Puerta de Hierro, Majadahonda, Spain. Electronic address: mariogonzalez@isciii.es.
authors.forename: Mario
authors.initials: M
authors.lastname: González-Sánchez
authors.affiliation: Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, Avda. Monforte de Lemos, 5, 28029 Madrid, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; IIS Puerta de Hierro, Majadahonda, Spain. Electronic address: pfernandezn@isciii.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernández-Navarro
mesh_terms: D000328:Adult; D000397:Air Pollution / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D007221:Industry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D015386:Hazardous Substances
keywords: BYM model; Endocrine disrupting chemicals; INLA; Industrial pollution; Ovarian cancer