title: Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases.
abstract: Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson&#39;s disease, especially through the so called gut-brain axis.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Herrera
authors.forename: Ana M
authors.initials: AM
authors.lastname: Espinosa-Oliva
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Oliva-Martin
authors.forename: Alejandro
authors.initials: A
authors.lastname: Carrillo-Jimenez
authors.forename: Jose L
authors.initials: JL
authors.lastname: Venero
authors.affiliation: Departamento de Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, 41012- Sevilla, SPAIN, and Instituto de Biomedicina de Sevilla (IBiS-Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla. 41013-Sevilla, Spain. depablos@us.es.
authors.forename: Rocio M
authors.initials: RM
authors.lastname: de Pablos
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D002908:Chronic Disease; D019587:Dietary Supplements; D004660:Encephalitis / Q000503:physiopathology; D005767:Gastrointestinal Diseases / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017628:Microglia / Q000473:pathology / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases