title: Changes in energy metabolism after induction therapy in patients with severe or moderate ulcerative colitis.
abstract: We investigated the changes in energy expenditure during induction therapy in patients with severe or moderate ulcerative colitis. Thirteen patients (10 men, 3 women; mean age, 36.5 years) with ulcerative colitis admitted to the Shiga University Hospital were enrolled in this study. We measured the resting energy expenditure and respiratory quotients of these patients before and after induction therapy with indirect calorimetry. We analyzed the changes of nutritional status and serum inflammatory cytokine levels and also evaluated the relationship between energy metabolism and disease activity by using the Seo index and Lichtiger index. The resting energy expenditure was 26.3 ± 3.8 kcal/kg/day in the active stage and significantly decreased to 23.5 ± 2.4 kcal/kg/day after induction therapy (p<0.01). The resting energy expenditure changed in parallel with the disease activity index and C-reactive protein and inflammatory cytokine levels. The respiratory quotient significantly increased after induction therapy. Thus, moderate to severe ulcerative colitis patients had a hyper-metabolic status, and the energy metabolism of these patients significantly changed after induction therapy. Therefore, we recommend that nutritional management with 30-34 kcal/kg/day (calculated as measured resting energy expenditure × activity factor, 1.3) may be optimal for hospitalized ulcerative colitis patients.
authors.affiliation: Division of Clinical Nutrition,Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Mai
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Division of Clinical Nutrition,Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: Division of Clinical Nutrition,Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Azusa
authors.initials: A
authors.lastname: Takaoka
authors.affiliation: Division of Clinical Nutrition,Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Kurihara
authors.affiliation: Division of Clinical Nutrition,Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Iwakawa
authors.affiliation: Department of Gastroenterology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Bamba
authors.affiliation: Division of Endoscopy, Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Ban
authors.affiliation: Department of Gastroenterology, Shiga University of Medical Science, Seta-Tsukinowa, Otsu-shi, Shiga 520-2192, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
keywords: energy expenditure; indirect calorimetry; induction therapy; respiratory quotient; ulcerative colitis