title: Cutaneous Immune Defenses Against Staphylococcus aureus Infections.
abstract: Staphylococcus aureus (S. aureus) is a virulent bacterium that abundantly colonizes inflammatory skin diseases. Since S. aureus infections occur in an impaired skin barrier, it is important to understand the protective mechanism through cutaneous immune responses against S. aureus infections and the interaction with Staphylococcal virulence factors. In this review, we summarize not only the pathogenesis and key elements of S. aureus skin infections, but also the cutaneous immune system against its infections and colonization. The information obtained from this area may provide the groundwork for further immunomodulatory therapies or vaccination strategies to prevent S. aureus infections.
authors.affiliation: Research Division for Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Korea;
authors.forename: Ji Hae
authors.initials: JH
authors.lastname: Choi
authors.affiliation: Research Division for Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Korea;
authors.forename: Ho Seong
authors.initials: HS
authors.lastname: Seo
authors.affiliation: Research Division for Biotechnology, Korea Atomic Energy Research Institute, Jeongeup, Korea;
authors.forename: Sang Young
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Department of Dermatology, University of California, San Francisco, and Northern California Institute for Research and Education, San Francisco, CA, USA.
authors.forename: Kyungho
authors.initials: K
authors.lastname: Park
keywords: Cutaneous immune system; Skin infection; Staphylococcus aureus