title: Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta-analysis.
abstract: To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to Hodgkin lymphoma (HL), we conducted a systematic review and meta-analysis of published case-control studies. Of the variants examined more than once in candidate gene association studies, we identified 21 studies that reported on 12 polymorphic variants in 10 genes. Data were also extracted from a published genome wide association study to allow analysis of an additional 47 variants in a further 30 genes. Promising associations were seen in nine of the variants (p < 0.05). Given that the estimated false positive report probabilities (FPRPs) for all associations are high (i.e. FPRP > 0.2), these findings should be interpreted with caution. While studies of candidate polymorphisms may be an attractive means of identifying risk factors for HL, future studies should employ sample sizes adequately powered to identify variants having only modest effects on HL risk. Furthermore, because of aetiological heterogeneity within HL, stratification of genotyping according to age, tumour Epstein-Barr virus status and histology is essential. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
authors.forename: Amit
authors.initials: A
authors.lastname: Sud
authors.affiliation: German Cancer Research Center, Heidelberg, Germany.
authors.forename: Kari
authors.initials: K
authors.lastname: Hemminki
authors.affiliation: Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Houlston
mesh_terms: D016022:Case-Control Studies; D004260:DNA Repair; D005189:False Positive Reactions; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007107:Immune System; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011336:Probability; D012307:Risk Factors
keywords: Hodgkin lymphoma; candidate gene; genetic susceptibility; meta-analysis; polymorphism; systematic review