title: Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects.
abstract: Jaundice is one of the notable markers of liver malfunction in our body, revealing a significant rise in the concentration of an endogenous yellow pigment bilirubin. We have described a method for measuring the optical spectrum of our conjunctiva and derived pigment concentration by using diffused reflection measurement. The method uses no prior model and is expected to work across the races (skin color) encompassing a wide range of age groups. An optical fiber-based setup capable of measuring the conjunctival absorption spectrum from 400 to 800 nm is used to monitor the level of bilirubin and is calibrated with the value measured from blood serum of the same human subject. We have also developed software in the LabVIEW platform for use in online monitoring of bilirubin levels in human subjects by nonexperts. The results demonstrate that relative absorption at 460 and 600 nm has a distinct correlation with that of the bilirubin concentration measured from blood serum. Statistical analysis revealed that our proposed method is in agreement with the conventional biochemical method. The innovative noncontact, low-cost technique is expected to have importance in monitoring jaundice in developing/underdeveloped countries, where the inexpensive diagnosis of jaundice with minimally trained manpower is obligatory.
authors.affiliation: S. N. Bose National Centre for Basic Sciences, Department of Chemical, Biological and Macromolecular Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Nabarun
authors.initials: N
authors.lastname: Polley
authors.affiliation: Jadavpur University Department of Physics, 188, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Srimoyee
authors.initials: S
authors.lastname: Saha
authors.affiliation: S. N. Bose National Centre for Basic Sciences, Department of Chemical, Biological and Macromolecular Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, IndiacBose Institute, Centre for Astroparticle Physics and Space Science, Block EN, Sector V.
authors.forename: Soumendra
authors.initials: S
authors.lastname: Singh
authors.affiliation: S. N. Bose National Centre for Basic Sciences, Department of Chemical, Biological and Macromolecular Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Jadavpur University Department of Physics, 188, Raja Subodh Chandra Mullick Road, Jadavpur, Kolkata 700032, India.
authors.forename: Sukhen
authors.initials: S
authors.lastname: Das
authors.affiliation: Calcutta Medical Research Institute, Suryodaya Eye Centre, 7/2, Diamond Harbour Road, Alipore, Kolkata 700027, India.
authors.forename: Bhaskar Roy
authors.initials: BR
authors.lastname: Choudhury
authors.affiliation: S. N. Bose National Centre for Basic Sciences, Department of Chemical, Biological and Macromolecular Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 098, India.
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Pal
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000032:analysis; D003228:Conjunctiva / Q000473:pathology; D004867:Equipment Design; D006801:Humans; D007565:Jaundice / Q000175:diagnosis* / Q000473:pathology*; D016014:Linear Models; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012984:Software
chemical_list: D001663:Bilirubin