title: Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction.
abstract: OBJECTIVE
  Carbohydrate metabolism disorders (CMD) significantly impact the development and progression of all forms of ischemic heart disease, and inflammation is regarded as a general pathogenetic link between CMD and ischemic heart disease.
  
  
  METHODS
  A total of 601 patients with ST segment elevation myocardial infarction (MI) (STEMI), admitted within 24 hours from the onset of symptoms during 1 year, were included in this registry study. The blood levels of inflammation markers were measured at days 10-14 with further follow up at 1 year.
  
  
  RESULTS
  The analysis of acute-phase percutaneous coronary intervention impact on the 1-year outcomes showed that endovascular revascularization significantly improved the 1-year prognosis of STEMI patients both with and without CMD. The analysis of inflammation markers showed significantly higher levels of interleukin (IL)-6 and sCD40L in MI patients with diabetes mellitus, and impaired glucose tolerance. Additionally, the patients with impaired glucose tolerance had significantly higher IL-12 levels. In the diabetic MI patients, the odds ratio of a poor 1-year outcome was high for patients with a high Killip classification of acute heart failure upon admission.
  
  
  CONCLUSIONS
  Persistent inflammation in STEMI patients with CMD undergoing percutaneous coronary intervention might be responsible for vascular complications within 1 year after MI. Comorbid diabetes mellitus or impaired glucose tolerance can amplify the significance of the inflammatory response for the development of adverse 1-year outcomes.
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation ; State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical Academy of the Russian Ministry of Health, Kemerovo, Russian Federation.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Belenkova
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation ; State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical Academy of the Russian Ministry of Health, Kemerovo, Russian Federation.
authors.forename: Viktoria
authors.initials: V
authors.lastname: Karetnikova
authors.affiliation: State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical Academy of the Russian Ministry of Health, Kemerovo, Russian Federation.
authors.forename: Aleksey
authors.initials: A
authors.lastname: Diachenko
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Gruzdeva
authors.affiliation: State Budgetary Healthcare Institution Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Blagoveshchenskaya
authors.affiliation: State Budgetary Healthcare Institution Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Molodtsova
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation.
authors.forename: Evgenya
authors.initials: E
authors.lastname: Uchasova
authors.affiliation: Federal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian Federation ; State Budgetary Educational Institution of Higher Professional Education Kemerovo State Medical Academy of the Russian Ministry of Health, Kemerovo, Russian Federation.
authors.forename: Olga
authors.initials: O
authors.lastname: Barbarash
keywords: carbohydrate metabolism disorders; inflammation percutaneous coronary intervention