title: Association of CRR9 locus with elevated risk of squamous cell carcinoma and basal cell carcinoma.
abstract: BACKGROUND
  Published studies have generated inconsistent results related to the contribution of CRR9 rs401681 C allele to the risk of developing non-melanoma skin cancer (NMSC), and it is the inconsistency that promoted us to undertake a meta-analysis to identify the degree of impact the C allele has on NMSC.
  
  
  METHODS
  The PubMed, Science Direct, Embase and Cochrane Library were thoroughly searched from the start of November 2013 to the end of April 2014 by using CRR9, polymorphism, skin cancer and their synonyms. Based on a total of 44,036 subjects, we calculated ORs and 95% CIs to measure the influence of the C allele on NMSC predisposition.
  
  
  RESULTS
  Overall, individuals carrying the risk C allele at rs401681 had 1.16 times (OR = 1.16, 95% CI: 1.10-1.21, heterogeneity: P = 0.298 and I2 = 0.166, Figure 2) greater risk of NMSC compared to the common T allele. In the further stratified analyses, we found a significant association between the C allele and BCC, Icelanders, and non-Icelanders.
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that the C allele at rs401681 is likely to modify the genetic predisposition to NMSC.
authors.affiliation: Department of Dermatology, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Jinqing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Yuejun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Wangzhou
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Xueyong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Burns and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University 569 Xinsi Road, Xi'an 710038, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
keywords: CRR9; Genetic risk; non-melanoma skin cancer