title: Involvement of estrogen-related receptor-γ and mitochondrial content in intrauterine growth restriction and preeclampsia.
abstract: OBJECTIVE
  To measure mitochondrial content and the expression of estrogen-related receptor-γ (ERRγ, a major inducer of mitochondrial biogenesis) in placentas from women with intrauterine growth restriction (IUGR) associated or not with pre-eclampsia (PE), relative to control placentas.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Teaching hospital and university research laboratory.
  
  
  METHODS
  Thirty-nine placentas from women with IUGR, 8 IUGR+PE, and 30 controls.
  
  
  METHODS
  None.
  
  
  METHODS
  Mitochondrial DNA and protein content, gene and protein expression.
  
  
  RESULTS
  We observed significantly lower placental mitochondrial DNA and protein contents (associated with down-regulation of ERRγ expression) in IUGR and IUGR+PE placentas, relative to control placentas. Our results also revealed that the placental mitochondrial DNA content was directly correlated with fetal weight. Moreover, we observed significantly lower peroxisome proliferator-activated receptor-γ coactivator-1α and sirtuin 1 messenger RNA expression levels in IUGR+PE placentas, relative to control placentas.
  
  
  CONCLUSIONS
  The low mitochondrial DNA and protein contents observed in IUGR placentas are probably due to down-regulation of ERRγ expression. This finding suggests that ERRγ has a major role in the control of placental development.
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France. Electronic address: dorothee.poidatz@neuf.fr.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Poidatz
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France; Service de Biologie Médicale, Centre Hospitalier Intercommunal (CHI) de Poissy-St-Germain, Poissy, France.
authors.forename: Esther
authors.initials: E
authors.lastname: Dos Santos
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Duval
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France.
authors.forename: Hadia
authors.initials: H
authors.lastname: Moindjie
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France; Service de Biologie Médicale, Centre Hospitalier Intercommunal (CHI) de Poissy-St-Germain, Poissy, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Serazin
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France; Département de Biologie de la Reproduction, Cytogénétique, Gynécologie et Obstétrique, CHI de Poissy-St-Germain, Poissy, France.
authors.forename: François
authors.initials: F
authors.lastname: Vialard
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France; Service de Biochimie et Génétique Moléculaire, Hôpital A. Paré, Boulogne, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: De Mazancourt
authors.affiliation: Unité de Pathologie Cellulaire et Génétique - Equipe d'Accueil 2493, Université de Versailles-St. Quentin, Unité de Formation et de Recherche des Sciences de la Santé, Montigny le Bretonneux, France.
authors.forename: Marie-Noëlle
authors.initials: MN
authors.lastname: Dieudonné
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000096:biosynthesis*; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D011247:Pregnancy; D011960:Receptors, Estrogen / Q000096:biosynthesis*
chemical_list: D004272:DNA, Mitochondrial; C490917:ESRRG protein, human; D011960:Receptors, Estrogen
keywords: ERRγ; ESRRG; IUGR; estrogen-related receptor γ; mitochondrial biogenesis; preeclampsia