title: Destabilization of Mutant p53 Proteins Suppresses Tumor Growth.
abstract: Sustained mutant p53 is required for tumor maintenance and is a therapeutic target in vivo.
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000188:drug therapy / Q000235:genetics; D009154:Mutation; D055550:Protein Stability / Q000187:drug effects; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D018841:HSP90 Heat-Shock Proteins; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53