title: [Herpes simplex virus type 1 latency and reactivation: an update].
abstract: Following primary infections HSV-1 replicates productively in epithelial cells and enters sensory neurons via nerve termini. After retrograde transport the virus genome is delivered into the cell nucleus, where it establishes lifelong latent infections. During latency, the virus genome remains as a chromatinized episome expressing only a set of latency-associated transcripts (LAT) and a group of microRNAs that inhibit expression of key lytic viral functions. Periodically the virus can reactivate to reinitiate lytic, secondary infections at peripheral tissues. The ability to establish both lytic and latent infections relies on the coexistence in the virus genome of two alternative gene expression programs, under the control of epigenetic mechanisms. Latency is an adaptive phenotype that allows the virus to escape immune host responses and to reactivate and disseminate to other hosts upon recognizing danger signals such as stress, neurologic trauma or growth factor deprivation.
authors.affiliation: UVSQ-Inserm U1179 - End-icap, Handicap Neuromusculaire - Physiopathologie, Biothérapie et Pharmacologie appliquées, UFR des sciences de la santé Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, 2, avenue de la source de la Bièvre, 78180 Montigny-le-Bretonneux, France.
authors.forename: Alejandro M
authors.initials: AM
authors.lastname: Aranda
authors.affiliation: UVSQ-Inserm U1179 - End-icap, Handicap Neuromusculaire - Physiopathologie, Biothérapie et Pharmacologie appliquées, UFR des sciences de la santé Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, 2, avenue de la source de la Bièvre, 78180 Montigny-le-Bretonneux, France.
authors.forename: Alberto L
authors.initials: AL
authors.lastname: Epstein
mesh_terms: D002213:Capsid / Q000502:physiology; D003588:Cytopathogenic Effect, Viral / Q000502:physiology; D044127:Epigenesis, Genetic; D004847:Epithelial Cells / Q000821:virology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology; D012367:RNA, Viral / Q000502:physiology; D011984:Sensory Receptor Cells / Q000821:virology; D013312:Stress, Physiological; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology; D014775:Virus Activation / Q000502:physiology*; D053586:Virus Internalization; D017735:Virus Latency / Q000502:physiology*; D057074:Virus Release / Q000502:physiology; D014779:Virus Replication / Q000502:physiology
chemical_list: D035683:MicroRNAs; D012367:RNA, Viral; D014764:Viral Proteins; C477253:latency associated transcript, herpes simplex virus-1