title: Adult Hippocampal Neurogenesis, Aging and Neurodegenerative Diseases: Possible Strategies to Prevent Cognitive Impairment.
abstract: The adult brain of humans and other mammals continuously generates new neurons throughout life. However, this neurogenic capacity is limited to two brain areas, the dentate gyrus (DG of the hippocampus and the subventricular zone (SVZ of the lateral ventricle. Although the DG generates new neurons, its neurogenic capacity declines with age and neurodegenerative diseases such as Alzheimer's disease (AD and Huntington's disease (HD. This review focuses on the role of newly-born neurons in cognitive processes, and discusses some of the strategies proposed in humans and animals to enhance neurogenesis and counteract age-related cognitive deficits, such as physical exercise and intake of natural products like omega-3 fatty acids, curcumin and flavanols.
authors.affiliation: Department of Physiology, Biophysics and Neuroscience, Centro de Investigacion y de Estudios Avanzados del IPN, Av. IPN 2508 Col. San Pedro Zacatenco, Mexico, D.F. CP 07360. cvivar@fisio.cinvestav.mx.
authors.forename: Carmen
authors.initials: C
authors.lastname: Vivar
mesh_terms: D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D003072:Cognition Disorders / Q000517:prevention & control*; D003474:Curcumin / Q000494:pharmacology; D015444:Exercise; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D044948:Flavonols / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000473:pathology; D008019:Life Style; D019636:Neurodegenerative Diseases / Q000503:physiopathology / Q000517:prevention & control*; D055495:Neurogenesis / Q000187:drug effects / Q000502:physiology
chemical_list: D015525:Fatty Acids, Omega-3; D044948:Flavonols; D003474:Curcumin