title: The diffusion tensor imaging (DTI) component of the NIH MRI study of normal brain development (PedsDTI).
abstract: The NIH MRI Study of normal brain development sought to characterize typical brain development in a population of infants, toddlers, children and adolescents/young adults, covering the socio-economic and ethnic diversity of the population of the United States. The study began in 1999 with data collection commencing in 2001 and concluding in 2007. The study was designed with the final goal of providing a controlled-access database; open to qualified researchers and clinicians, which could serve as a powerful tool for elucidating typical brain development and identifying deviations associated with brain-based disorders and diseases, and as a resource for developing computational methods and image processing tools. This paper focuses on the DTI component of the NIH MRI study of normal brain development. In this work, we describe the DTI data acquisition protocols, data processing steps, quality assessment procedures, and data included in the database, along with database access requirements. For more details, visit http://www.pediatricmri.nih.gov. This longitudinal DTI dataset includes raw and processed diffusion data from 498 low resolution (3 mm) DTI datasets from 274 unique subjects, and 193 high resolution (2.5 mm) DTI datasets from 152 unique subjects. Subjects range in age from 10 days (from date of birth) through 22 years. Additionally, a set of age-specific DTI templates are included. This forms one component of the larger NIH MRI study of normal brain development which also includes T1-, T2-, proton density-weighted, and proton magnetic resonance spectroscopy (MRS) imaging data, and demographic, clinical and behavioral data.
authors.affiliation: Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD, USA.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Walker
authors.affiliation: Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD, USA.
authors.forename: Lin-Ching
authors.initials: LC
authors.lastname: Chang
authors.affiliation: Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD, USA.
authors.forename: Amritha
authors.initials: A
authors.lastname: Nayak
authors.affiliation: Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD, USA.
authors.forename: M Okan
authors.initials: MO
authors.lastname: Irfanoglu
authors.affiliation: Washington University in St. Louis, Department of Psychiatry, Saint Louis, MO, USA.
authors.forename: Kelly N
authors.initials: KN
authors.lastname: Botteron
authors.affiliation: Department of Child Psychiatry, University of California in Los Angeles, Los Angeles, CA, USA.
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: McKinstry
authors.affiliation: Departments of Neurology, Psychiatry and Radiology, Boston Children's Hospital, Boston, MA, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rivkin
authors.affiliation: The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
authors.forename: Dah-Jyuu
authors.initials: DJ
authors.lastname: Wang
authors.affiliation: Clinical Neuroscience Research Branch, Division of Translational Research, NIMH, NIH, Bethesda, MD, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Rumsey
authors.affiliation: Program on Pediatric Imaging and Tissue Sciences, NICHD, NIH, Bethesda, MD, USA. Electronic address: cp1a@nih.gov.
authors.forename: Carlo
authors.initials: C
authors.lastname: Pierpaoli
mesh_terms: D000293:Adolescent; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development*; D001927:Brain Diseases / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005006:Ethnicity; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D033181:Information Dissemination; D008137:Longitudinal Studies; D009316:National Institutes of Health (U.S.); D011786:Quality Control; D012016:Reference Values; D012959:Socioeconomic Factors; D014481:United States; D055815:Young Adult
keywords: DTI; Database; Diffusion; Longitudinal; MRI; Multicenter; NIH; Pediatric