title: Targeting roles of inflammatory microenvironment in lung cancer and metastasis.
abstract: Inflammatory cells and mediators are essential components in tumor microenvironment and play decisive roles in the initiation, proliferation, survival, promotion, invasion, or metastasis of lung cancer. Clinical and epidemiologic studies suggested a strong association between inflammation and lung cancer and an influence of immune surveillances and tumor responses to chemotherapeutic drugs, although roles of inflammation in lung cancer remain unclear. The present review outlined roles of inflammation in lung cancer, with particular focus on inflammatory components, types, biomarkers, or principal mechanisms by which the inflammation contributes to the development of lung cancer. The cancer-associated inflammatory cells (CICs) should be furthermore defined and include cancer-specific and interacted cells with inflammatory or inflammation-like characteristics, e.g., innate or adaptive immune cells and cancer tissue cells. We also discuss targeting potentials of inflammation in the prevention and treatment of lung cancer. The diversity of cancer-related inflammatory microenvironment is instrumental to design novel therapeutic approaches for lung cancer.
authors.affiliation: Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Biomedical Research Center, Fudan University, Shanghai, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Shi
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.forename: Jiayan
authors.initials: J
authors.lastname: Hou
authors.forename: Bijun
authors.initials: B
authors.lastname: Zhu
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Min
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Zhang
authors.forename: Dongli
authors.initials: D
authors.lastname: Song
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Cheng
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology*; D009362:Neoplasm Metastasis / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor