title: Impact of V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 Gene Polymorphisms Upon Susceptibility to Autoimmune Diseases: A Meta-Analysis.
abstract: V-ets erythroblastosis virus E26 oncogene homolog 1 (ETS1) is recognized as a gene of risk to autoimmune diseases (ADs). Two single nucleotide polymorphisms (SNPs) in ETS1 (rs1128334 G>A and rs10893872 T>C) were considered associated with ADs risk. However, the results remain conflicting.We performed a meta-analysis to evaluate more precise estimations of any relationship. We searched PubMed, OvidSP, and Chinese National Knowledge Infrastructure databases (papers published prior to September 12, 2014) and extracted data from eligible studies. Meta-analysis was performed using the STATA 12.0 software. Random effect model or fixed effect model were chosen according to the study heterogeneities.A total of 11 studies including 7359 cases (9660 controls) for rs1128334 and 8 studies including 5419 cases (7122 controls) for rs10893872 were involved in this meta-analysis. Overall, our results showed that there were significant associations for rs1128334 with AD risk in 5 genetic models, both in pooled analysis and in systemic lupus erythematous (SLE) subgroup, and in 3 genetic models of the uveitis subgroup. Although for rs10893872, the results showed that there were significant associations in allele model both in pooled analysis and in SLE subgroup. As a conclusion, this meta-analysis demonstrated that these 2 SNPs (rs1128334 and rs10893872) in ETS1 were associated with ADs risk.
authors.affiliation: From the School of Biotechnology (YZ), Southern Medical University, Guangzhou, China; Department of Physiology and Biophysics (ML, FH), Virginia Commonwealth University School of Medicine, Richmond, VA; Nanfang Hospital (JL, WL, XN, CL), Southern Medical University, Guangzhou; Department of Intensive Care Unit (ZM), Chinese PLA General Hospital, Beijing; First College of Clinical Medicine (NZ), Shandong University of Traditional Chinese Medicine, Jinan, China; Department of Medicine (LZ), Virginia Commonwealth University, Richmond, VA; The Eye Hospital (JZ), Wenzhou Medical University, Wenzhou; and School of Traditional Chinese Medicine (XN, CL), Southern Medical University, Guangzhou, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Miao
authors.initials: M
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Fiza
authors.initials: F
authors.lastname: Hashmi
authors.forename: Zhi
authors.initials: Z
authors.lastname: Mao
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Weiran
authors.initials: W
authors.lastname: Lv
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zheng
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Nie
authors.forename: Changzheng
authors.initials: C
authors.lastname: Li
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics*
chemical_list: C494041:ETS1 protein, human; D050784:Proto-Oncogene Protein c-ets-1