title: The extracellular matrix and insulin resistance.
abstract: The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling as a result of injury and repair. Over the past decade, mounting evidence in humans and rodents suggests that ECM remodeling is associated with diet-induced insulin resistance in several metabolic tissues. In addition, integrin receptors for the ECM have also been implicated in the regulation of insulin action. This review addresses what is currently known about the ECM, integrins, and insulin action in the muscle, liver, and adipose tissue. Understanding how ECM remodeling and integrin signaling regulate insulin action may aid in the development of new therapeutic targets for the treatment of insulin resistance and type 2 diabetes (T2D).
authors.affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Williams
authors.affiliation: Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
authors.forename: Li
authors.initials: L
authors.lastname: Kang
authors.affiliation: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA; Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, TN, USA. Electronic address: david.wasserman@vanderbilt.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Wasserman
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D016023:Integrins / Q000378:metabolism; D009765:Obesity / Q000378:metabolism
chemical_list: D016023:Integrins
keywords: extracellular matrix; glucose homeostasis; insulin resistance; integrins; liver; muscle