title: The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis.
abstract: Many studies have reported the association between tumor necrosis factor-α (TNF-α)-238 polymorphism and digestive system cancer susceptibility, but the results were inconclusive. We performed a meta-analysis to derive a more precise estimation of the relationship between TNF-α-238 G/A polymorphism and digestive system cancer risk. Pooled analysis for the TNF-α-238 G/A polymorphism contained 26 studies with a total of 4849 cases and 8567 controls. The meta-analysis observed a significant association between TNF-α-238 G/A polymorphism and digestive system cancer risk in the overall population (GA vs GG: OR 1.19, 95 % CI 1.00-1.40, P heterpgeneity = 0.016; A vs G: OR 1.19, 95 % CI 1.03-1.39, P heterpgeneity = 0.015; dominant model: OR 1.20, 95 % CI 1.02-1.41, P heterpgeneity = 0.012). In the analysis of the ethnic subgroups, however, similar results were observed only in the Asian population, but not in the Caucasian population. Therefore, this meta-analysis suggests that TNF-α-238 G/A polymorphism is associated with a significantly increased risk of digestive system cancer. Further large and well-designed studies are needed to confirm these findings.
authors.affiliation: Department of Gastroenterology, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, 830011, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Hui
authors.affiliation: Department of Emergency, Urumchi First People's Hospital, Urumchi, 830000, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Infectious Diseases, The Second Affiliated Hospital of Xinjiang Medical University, Urumchi, 830011, China. jiangying_med@sina.com.|Department of Infectious Diseases, The Second Affiliated Hospital of Xinjiang Medical University, No. 38, Lane 2, Nanhu East Road, Urumchi, 830000, China. jiangying_med@sina.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D044466:Asian People; D004067:Digestive System Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Digestive system cancer; Meta-analysis; Polymorphism; Tumor necrosis factor-α