title: Pharmacological evaluation of nasal delivery of selegiline hydrochloride-loaded thiolated chitosan nanoparticles for the treatment of depression.
abstract: The aim of the present study was to investigate the propensity of thiolated chitosan nanoparticles (TCNs) to enhance the nasal delivery of selegiline hydrochloride. TCNs were synthesized by the ionic gelation method. The particle size distribution (PDI), entrapment efficiency (EE), and zeta potential of modified chitosan (CS) nanoparticles were found to be 215 ± 34.71 nm, 70 ± 2.71%, and + 17.06 mV, respectively. The forced swim and the tail suspension tests were used to evaluate the anti-depressant activity, in which elevated immobility time was found to reduce on treatment. TCNs seem to be promising candidates for nose-to-brain delivery in the evaluation of antidepressant activity.
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Singh
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Muzamil
authors.initials: M
authors.lastname: Rashid
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Supandeep Singh
authors.initials: SS
authors.lastname: Hallan
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Neelesh Kumar
authors.initials: NK
authors.lastname: Mehra
authors.affiliation: b Department of Pharmacology , I.S.F. College of Pharmacy , Moga, Punjab , India.|c Brain Research Laboratory, Department of Pharmacology , Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) , Puncak Alam , Malaysia.
authors.forename: Atish
authors.initials: A
authors.lastname: Prakash
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D003863:Depression / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D012642:Selegiline; D048271:Chitosan
keywords: depression; nasal delivery; selegiline hydrochloride; thiolated chitosan nanoparticles