title: Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells.
abstract: The better definition of the mutual sustainment between neoplastic cells and immune system has been translated from the bench to the bedside acquiring value as prognostic factor. Additionally, it represents a promising tool for improving therapeutic strategies. In this context, myeloid-derived suppressor cells (MDSCs) have gained a central role in tumor developing with consequent therapeutic implications. In this review, we will focus on the biological and clinical impact of the study of MDSCs in the settings of lymphoid malignancies.
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Calogero
authors.initials: C
authors.lastname: Vetro
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Romano
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Ancora
authors.affiliation: Department of Radiology, University of Palermo , Palermo , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Coppolino
authors.affiliation: Department of Biological, Geological and Environmental Sciences, University of Catania , Catania , Italy.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Brundo
authors.affiliation: Department of Biological, Geological and Environmental Sciences, University of Catania , Catania , Italy ; National Research Council Institute for Agricultural and Forest Systems in the Mediterranean, National Research Council , Catania , Italy.
authors.forename: Salvatore A
authors.initials: SA
authors.lastname: Raccuia
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Puglisi
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Tibullo
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Piera
authors.initials: P
authors.lastname: La Cava
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Cesarina
authors.initials: C
authors.lastname: Giallongo
authors.affiliation: Division of Haematology, AOU "Policlinico - Vittorio Emanuele", University of Catania , Catania , Italy.
authors.forename: Nunziatina L
authors.initials: NL
authors.lastname: Parrinello
keywords: MDSCs; lymphoma; microenvironment; prognostication