title: [Normative Database of Optical Coherence Tomography Parameters in Childhood].
abstract: BACKGROUND
  Optical coherence tomography is a technology that allows obtaining high resolution images of tissues in vivo, enabling the measurement of ocular structures, including the retinal nerve fiber layer and macular thickness. As a noninvasive test it's particularly useful in children, but its applicability is limited by the existence of normative values for adults only.
  
  
  OBJECTIVE
  To establish the pediatric normative values of retinal nerve fiber layer thickness and macular thickness and to investigate its relationship with sex, age, refraction, eye side and ocular dominance.
  
  
  METHODS
  Ophthalmologic examination and Cirrus HD-optical coherence tomography (Carl Zeiss Meditec) were carried out on 153 children aged 4 to 17 years old.
  
  
  RESULTS
  We obtained a mean retinal nerve fiber layer average thickness of 97.90 μm. No significant differences were detected between genders, however the eye side and ocular dominance had significant influence on retinal nerve fiber layer thickness. Retinal nerve fiber layer thickness increased significantly with more positive refraction. With the Macular Cube 512 x 128 protocol we found that the average central subfield showed the smallest thickness (250.35 μm) and boys had higher macular thickness.
  
  
  CONCLUSIONS
  The values of the retinal nerve fiber layer thickness and macular thickness obtained are comparable to recent studies. The distribution of retinal nerve fiber layer thickness in quadrants is in agreement with the normal distribution of retinal nerve fiber layer. Macular thickness proved to be higher in males (center field and inner ring), data consistent with previous studies.
  
  
  CONCLUSIONS
  We establish the normative retinal nerve fiber layer thickness and macular thickness in healthy Portuguese children. These data enhance the evaluation and interpretation of parameters obtained by optical coherence tomography in the diagnosis of pediatric disorders in clinical practice.
authors.affiliation: Serviço de Oftalmologia. Hospital de Braga. Braga. Portugal.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Queirós
authors.affiliation: Serviço de Oftalmologia. Hospital de Braga. Braga. Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Freitas
authors.affiliation: Serviço de Oftalmologia. Hospital de Braga. Braga. Portugal.
authors.forename: Sandra
authors.initials: S
authors.lastname: Guimarães
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008297:Male; D011174:Portugal; D012016:Reference Values; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence