title: Gene expression profiling reveals a possible role for somatostatin in the innate immune response of the liver.
abstract: Somatostatin is a neuropeptide hormone that inhibits pituitary growth hormone (GH) release. Using microarray analysis of gene expression in the livers of wildtype control and somatostatin knockout mice, we have previously identified a panel of genes whose GH-dependent and sexually dimorphic expression patterns are significantly altered by the absence of somatostatin (1). Here, we provide methodological and analytical details of that study, the raw data of which is deposited in the Gene Expression Omnibus as data set GSE56520. In addition, we performed further gene ontology analysis of the data and found that the differential expression of a second subset of genes in the livers of somatostatin-knockout mice versus wildtype controls is likely independent of GH signaling and involved in the innate immune response.
authors.affiliation: Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI (JMA); Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI (JMA, MJL).
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Adams
authors.affiliation: Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI (JMA); Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI (JMA, MJL).
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Low
keywords: innate immune system; liver; microarray; somatostatin