title: The Protective Effect of Puerarin on Myocardial Infarction Reperfusion Injury (MIRI): A Meta-Analysis of Randomized Studies in Rat Models.
abstract: BACKGROUND
  Although puerarin is generally considered as a protective agent for cardio-cerebrovascular diseases, the exact effect on reducing myocardial infarction reperfusion injury (MIRI) is not well understood. This study aimed to pool previous randomized controlled studies based on rat models to evaluate the effects of puerarin on MIRI.
  
  
  METHODS
  Relevant studies were searched among PubMed, Embase, Medline, and CNKI (China National Knowledge Infrastructure). To assess the therapeutic effects of protective effects of puerarin on myocardial infarction reperfusion injury, the outcome indicators which were reported in at least 3 original studies were extracted and pooled, including size of myocardial ischemia (MIS) and myocardial infarction (MIN), creatine kinase (CK), methylene dioxyamphetamine (MDA), and superoxide dismutase (SOD).
  
  
  RESULTS
  Administration of puerarin could effectively reduce the size of MIN after MIR (mean difference: -29.20, 95%CI: -44.90 to -13.51, p=0.0003). Puerarin directly led to decreased CK (mean difference: -6.89, 95%CI: -9.40 to -4.38, p=0.00001) and MDA (mean difference: -2.41, 95%CI: -3.14 to -1.68, p<0.00001) and increased serum SOD (mean difference: 63.97, 95%CI: 38.19 to 89.75, p<0.00001).
  
  
  CONCLUSIONS
  Puerarin might have a protective effect in myocardial tissues during MIRI through increasing SOD and decreasing CK and MDA. However, more animal studies and randomized controlled clinical trials are required to confirm these results.
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Huang
authors.initials: H
authors.lastname: Wenjun
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Wen
authors.initials: W
authors.lastname: Jing
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Tao
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Mao
authors.initials: M
authors.lastname: Ling
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Yang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Zeng
authors.initials: Z
authors.lastname: Xiaorong
authors.affiliation: Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, China (mainland).
authors.forename: Zhou
authors.initials: Z
authors.lastname: Rui
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007529:Isoflavones / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000517:prevention & control; D017202:Myocardial Ischemia / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000517:prevention & control*; D020011:Protective Agents / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007529:Isoflavones; D020011:Protective Agents; C033607:puerarin