title: Randomized clinical trial of the efficacy of dentifrices containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride over two years.
abstract: OBJECTIVE
  A double blind, randomized, unsupervised, parallel-group clinical trial was conducted on over 5,500 children in Sichuan Province, China. This clinical trial compared the anti-caries efficacy of two test dentifrices to that of a control dentifrice.
  
  
  METHODS
  The test dentifrices contained 1.5% arginine, 1450 ppm fluoride as sodium monofluorophosphate (MFP), and an insoluble calcium compound (either dicalcium phosphate or calcium carbonate). The positive control dentifrice contained 1450 ppm fluoride as sodium fluoride (NaF), in a silica base. The children were randomly assigned one of the toothpastes, and children residing in the same household were assigned the same dentifrice to use at home, twice a day.
  
  
  RESULTS
  Three calibrated dentists examined the children at baseline, as well as after one and two years of product use. After one year of product use, there were no statistically significant differences among the three groups with respect to decayed, missing, and filled teeth (DMFT) or to decayed, missing, and filled surfaces (DMFS). After two years of product use, subjects in the two test groups using the dentifrices containing 1.5% arginine, 1450 ppm fluoride as MFP, and an insoluble calcium compound had a statistically significant reduction in DMFT increments of 20.5% and in DMFS increments of 19.6% when compared to subjects in the group using the positive control dentifrice. After two years, there were no statistically significant differences with respect to DMFT or DMFS between the two groups using the dentifrices containing 1.5% arginine, 1450 ppm fluoride as MFP, and an insoluble calcium compound.
  
  
  CONCLUSIONS
  The use of the two test dentifrices demonstrated significant reductions in decayed, missing, and filled teeth and surfaces, however there was no statistically significant different between the two test dentifrices clinically after two years of using the toothpastes. The results of this two-year clinical investigation support the conclusion that dentifrices containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride as MFP provide superior protection against caries lesion cavitation compared to a positive control dentifrice containing only 1450 ppm fluoride as NaF.
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Yisi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Xianjun
authors.initials: X
authors.lastname: Jiang
authors.lastname: Hu Deyu
authors.forename: Luis R
authors.initials: LR
authors.lastname: Mateo
authors.forename: Boyce M
authors.initials: BM
authors.lastname: Morrison
authors.forename: Yun-Po
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use; D002648:Child; D002681:China; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010710:Phosphates / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000627:therapeutic use; D014099:Toothbrushing; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D003802:Dentifrices; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D001120:Arginine; C020243:calcium phosphate; D002119:Calcium Carbonate; D005459:Fluorides