title: Hydrous RuO2 nanoparticles as an efficient NIR-light induced photothermal agent for ablation of cancer cells in vitro and in vivo.
abstract: Metal oxides are receiving an incremental attention in recent years for their potential applications in ablation of cancer cells due to their efficient photothermal conversion and good biocompatibility, but the large sizes and poor photo-stability will seriously limit their practical application. Herein, hydrous RuO2 nanoparticles were synthesized by a facile hydrothermal treatment and surface-modified with polyvinylpyrrolidone (PVP) coating. PVP-coated RuO2 nanoparticles exhibit a well dispertion in saline solution, strong characteristic plasmonic absorption in NIR region, enhanced photothermal conversion efficiency of 54.8% and remarkable photo-stability under the irridation of an 808 nm laser. The nanoparticles were further employed as a new photothermal ablation agent for cancer cells which led rapidly to cellular deaths both in vitro and in vivo.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. hu.junqing@dhu.edu.cn.
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Xiao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Jiang
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Xijian
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qilong
authors.initials: Q
authors.lastname: Ren
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Qin
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D017975:Ruthenium Compounds; C029017:ruthenium dioxide