title: Stereoselective Syntheses of α,β-Unsaturated γ-Amino Esters Through Phosphine-Catalyzed γ-Umpolung Additions of Sulfonamides to γ-Substituted Allenoates.
abstract: α,β-Unsaturated γ-amino esters can be synthesized efficiently and stereoselectively through phosphine-catalyzed γ-umpolung additions of sulfonamides to γ-substituted allenoates. The structures of the sulfonamide and γ-substituted allenoate partners can be varied to achieve a range of α,β-unsaturated γ-amino esters with potentially interesting chemical and biological properties.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569.
authors.forename: Qing-Fa
authors.initials: QF
authors.lastname: Zhou
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569.
authors.forename: Ohyun
authors.initials: O
authors.lastname: Kwon
keywords: phosphine; stereoselective synthesis; γ-substituted allenoate; γ-umpolung addition