title: Preliminary study of FMO1, FMO5, CYP21, ESR1, PLIN2 and SULT2A1 as candidate gene for compounds related to boar taint.
abstract: An association study between polymorphisms of six genes and boar taint related compounds androstenone, skatole and indole was performed in a boar population (n=370). Significant association (P<0.05) was detected for SNP of FMO5 (g.494A>G) with all boar taint compounds, SNP of CYP21 (g.3911T>C) with skatole and indole, and SNP of ESR1 (g.672C>T) with androstenone and indole. mRNA expression of CYP21 and ESR1 was higher in CAB (castrated boar) compared to non-castrated boars; whereas, the expression of FMO5 and ESR1 was higher in LBT (low boar taint) compared to HBT (high boar taint) in liver tissue. FMO5, CYP21 and ESR1 proteins were less detectable in HBT compared with LBT and CAB in liver tissues. These findings suggest that FMO5, CYP21 and ESR1 gene variants might have effects on the boar taint compounds.
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: cneu@itw.uni-bonn.de.
authors.forename: Christiane
authors.initials: C
authors.lastname: Neuhoff
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany; Department of Animal Production and Technology, Faculty of Animal Science, Bogor Agricultural University, 16680 Bogor, Indonesia. Electronic address: agun@itw.uni-bonn.de.
authors.forename: Asep
authors.initials: A
authors.lastname: Gunawan
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: omer2081@hotmail.com.
authors.forename: Malik Omar
authors.initials: MO
authors.lastname: Farooq
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany; Department of Animal Science, Faculty of Agriculture, Erciyes University, 38039 Kayseri, Turkey. Electronic address: ucin@itw.uni-bonn.de.
authors.forename: Mehmet Ulas
authors.initials: MU
authors.lastname: Cinar
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: cgro@itw.uni-bonn.de.
authors.forename: Christine
authors.initials: C
authors.lastname: Große-Brinkhaus
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: ssud@itw.uni-bonn.de.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Sahadevan
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: lfri@itw.uni-bonn.de.
authors.forename: Luc
authors.initials: L
authors.lastname: Frieden
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: dtes@itw.uni-bonn.de.
authors.forename: Dawit
authors.initials: D
authors.lastname: Tesfaye
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: etho@itw.uni-bonn.de.
authors.forename: Ernst
authors.initials: E
authors.lastname: Tholen
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: cloo@itw.uni-bonn.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Looft
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: ksch@itw.uni-bonn.de.
authors.forename: Karl
authors.initials: K
authors.lastname: Schellander
authors.affiliation: Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, 53115 Bonn, Germany. Electronic address: judd@itw.uni-bonn.de.
authors.forename: Muhammad Jasim
authors.initials: MJ
authors.lastname: Uddin
mesh_terms: D000736:Androstenes / Q000737:chemistry; D000818:Animals; D047628:Estrogen Receptor alpha / Q000235:genetics*; D063427:Food Quality; D060005:Genotyping Techniques; D007211:Indoles / Q000737:chemistry; D008099:Liver / Q000378:metabolism; D008297:Male; D008460:Meat / Q000032:analysis*; D010105:Oxygenases / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012862:Skatole / Q000737:chemistry; D013255:Steroid 21-Hydroxylase / Q000235:genetics*; D015238:Sulfotransferases / Q000235:genetics; D013552:Swine / Q000235:genetics*
chemical_list: D000736:Androstenes; D047628:Estrogen Receptor alpha; D007211:Indoles; D012333:RNA, Messenger; C000214:androst-16-en-3-one; C030374:indole; D012862:Skatole; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); D013255:Steroid 21-Hydroxylase; D015238:Sulfotransferases; C028152:alcohol sulfotransferase
keywords: Association; Boar taint; Gene polymorphism; Genetic marker