title: [Screening marine resources to find novel chemical inhibitors of disease-relevant protein kinases].
abstract: Since the early 1970's, investigators at Station Biologique de Roscoff (SBR), France, have been using marine organisms as models to describe molecular pathways conserved through evolution in mammalian cells (e.g. the cyclin-dependent kinases involved in the control of the cell division cycle). Some kinases are misregulated in various human pathologies, including cancers. Using a specialized screening approach, chemical libraries were analysed, using on-site facilities at Roscoff, in order to identify small chemical inhibitors of protein kinases. Eight chemical scaffolds produced by marine organisms were characterized as candidate drugs by our screening facility, some of which are being considered as chemical tools to pinpoint specific cellular functions of the targeted kinases. In this review, we describe our existing screening facilities and we discuss new perspectives related to marine bioprospecting.
authors.affiliation: CNRS/UPMC USR3151, plate-forme de criblage KISSf (kinase inhibitor specialized screening facility), station biologique de Roscoff, place Georges Teissier, CS 90074, 29688 Roscoff Cedex, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Baratte
authors.affiliation: CNRS/UPMC USR3151, plate-forme de criblage KISSf (kinase inhibitor specialized screening facility), station biologique de Roscoff, place Georges Teissier, CS 90074, 29688 Roscoff Cedex, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Serive
authors.affiliation: CNRS/UPMC USR3151, plate-forme de criblage KISSf (kinase inhibitor specialized screening facility), station biologique de Roscoff, place Georges Teissier, CS 90074, 29688 Roscoff Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bach
mesh_terms: D000047:Academies and Institutes; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms / Q000737:chemistry*; D001331:Automation; D002317:Cardiovascular Agents / Q000302:isolation & purification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery / Q000295:instrumentation / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods*; D004354:Drug Screening Assays, Antitumor / Q000295:instrumentation / Q000379:methods; D004463:Ecology; D005602:France; D006801:Humans; D008386:Marine Biology / Q000458:organization & administration; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011494:Protein Kinases / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D012371:Robotics
chemical_list: D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases