title: Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report.
abstract: Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast differentiation and activation. We aim to evaluate the association between SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) in the TNFRSF11B (OPG) gene, and osteoporosis in RA. We included 81 women with RA and 52 healthy subjects in a cross-sectional study, genotyped them, and measured bone mineral density (BMD) at the lumbar spine and the femoral neck. Mean age in RA was 50 ± 12 with disease duration of 12 ± 8 years. According to BMD results, 23 (33.3%) were normal and 46 (66.7%) had osteopenia/osteoporosis. We found a higher prevalence of C allele for C950T SNP in RA. Polymorphisms C209T and T245G did not reach statistical significance in allele distribution. Further studies including patients from other regions of Latin America with a multicenter design to increase the sample size are required to confirm our findings and elucidate if C950T SNP could be associated with osteoporosis in RA.
authors.affiliation: Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44100 Zapopan, JAL, Mexico.
authors.forename: Maria Guadalupe
authors.initials: MG
authors.lastname: Zavala-Cerna
authors.affiliation: Division de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico.
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Moran-Moguel
authors.affiliation: Division de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico.
authors.forename: Jesus Alejandro
authors.initials: JA
authors.lastname: Cornejo-Toledo
authors.affiliation: Programa de Becarios en Investigacion del Instituto Mexicano del Seguro Social, Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Norma Guadalupe
authors.initials: NG
authors.lastname: Gonzalez-Montoya
authors.affiliation: Division de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico.
authors.forename: Jose
authors.initials: J
authors.lastname: Sanchez-Corona
authors.affiliation: Division de Investigacion en Salud, UMAE, Hospital de Especialidades, CMNO, IMSS and Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Paramo
authors.affiliation: Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44100 Zapopan, JAL, Mexico ; Unidad de Investigacion en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente del Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico ; Servicio de Medicina Interna, Inmunologia y Reumatologia, Hospital General de Occidente, Secretaria de Salud Jalisco, 45170 Guadalajara, JAL, Mexico.
authors.forename: Arnulfo Hernan
authors.identifier: 0000-0003-3061-521X
authors.initials: AH
authors.lastname: Nava-Zavala
authors.affiliation: Unidad de Medicina Familiar 2, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, Mexico.
authors.forename: Erika Anita
authors.initials: EA
authors.lastname: Aguilar-Chavez
authors.affiliation: Departamento de Medicina Interna-Reumatologia, Hospital General de Zona 14, Instituto Mexicano del Seguro Social, 44860 Guadalajara, JAL, Mexico.
authors.forename: Miriam Fabiola
authors.initials: MF
authors.lastname: Alcaraz-Lopez
authors.affiliation: Programa de Becarios en Investigacion del Instituto Mexicano del Seguro Social, Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Alicia Guadalupe
authors.initials: AG
authors.lastname: Gonzalez-Sanchez
authors.affiliation: Departamento de Medicina Interna-Reumatologia del Hospital General Regional No. 110, Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Laura
authors.identifier: 0000-0002-6517-6344
authors.initials: L
authors.lastname: Gonzalez-Lopez
authors.affiliation: Unidad de Investigación en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente del Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Jorge Ivan
authors.identifier: 0000-0003-0001-3787
authors.initials: JI
authors.lastname: Gamez-Nava
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D015519:Bone Density / Q000235:genetics; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics*; D053244:Osteoprotegerin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D053245:RANK Ligand / Q000235:genetics; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C506030:TNFRSF11B protein, human