title: Antidepression medication improves quality of life in elderly patients with benign prostatic hyperplasia and depression.
abstract: We aim to explore the influence of an antidepression medication on symptom scores and quality of life in elderly patients with benign prostatic hyperplasia accompanied by depression. We conducted a randomized controlled clinical trial which included 94 elderly patients with benign prostatic hyperplasia accompanied by depression in Xuan Wu Hospital and Beijing Boai Hospital during August 2008 to May 2012. The study was designed to compare outcomes related to patient quality of life (QoL). The patients were randomly assigned to one of two groups, consisting of a control group (n = 47) and a therapy group (n = 47), and were followed up for 3 months. The pre-treatment and post-treatment changes among patients in the two groups were compared using their respective IPSS symptom scores, HAM-D scores, and scores on the Short Form 36 Health Survey. Following treatment, the patient IPSS symptom scores in the therapy group were significantly lower than those in the control group (10.74 ± 4.72 vs. 16.42 ± 8.09, respectively; t = 4.157, P < 0.05). Additionally, each measured dimension of QoL was significantly higher in the therapy group [total score (69.12 ± 3.92) vs. (61.30 ± 3.51), P < 0.05]. The results show antidepression medication can improve the symptoms and quality of life among elderly patients with benign prostatic hyperplasia accompanied by depression. Our findings suggest that an antidepression medication should be included when treating elderly patients with benign prostatic hyperplasia.
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Emergency, Three Gorges University People's Hospital, The First People's Hospital of Yichang Yichang 443000, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Emergency, Beijing Boai Hospital, China Rehabilitation Research Center Beijing 100068, China.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Qian
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Jieyu
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Geriatrics, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
keywords: Benign prostatic hyperplasia; depression; elderly; quality of life; symptom score