title: Can the ductus venosus doppler predict the hemoglobinopathies?
abstract: OBJECTIVE
  The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (week-day) in pregnant women with hemoglobinopaties and its relation with fetal outcomes.
  
  
  METHODS
  A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed.
  
  
  RESULTS
  The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 ± 0.7) than control group (10.67 ± 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 ± 1.66, 8.90 ± 0.81, 2.97 ± 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (β = 1.07, P = 0.001), S/D (β = 2.61, P = 0.001) and reverse 'a' wave (β = 2.46, P = 0.004).
  
  
  CONCLUSIONS
  Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.
authors.affiliation: Antakya State Hospital, Obstetrics and Gynecology Clinic Hatay, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Karateke
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Dilek Benk
authors.initials: DB
authors.lastname: Silfeler
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Güngören
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Raziye Keskin
authors.initials: RK
authors.lastname: Kurt
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Ayşe Güler
authors.initials: AG
authors.lastname: Okyay
authors.affiliation: Department of Medical Physiology, Medical Faculty, Mustafa Kemal University Hatay, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.affiliation: Kadirli State Hospital, Biochemistry Clinic Osmaniye, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Ulutas
authors.affiliation: Kadirli State Hospital, Obstetrics and Gynecology Clinic Osmaniye, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Un
authors.affiliation: Department of Physical Medicine and Rehabilitation, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Paksoy
authors.affiliation: Department of Obstetrics and Gynecology, Mustafa Kemal University, Faculty of Medicine Hatay, Turkey.
authors.forename: Ali Ulvi
authors.initials: AU
authors.lastname: Hakverdi
keywords: Hemoglobinopathies; ductus venosus doppler; ultrasonography