title: Use of common analgesics is not associated with ovarian cancer survival.
abstract: BACKGROUND
  Use of analgesics has been associated with lower risk of ovarian cancer, but, to date, very few studies have explored the association between analgesics and ovarian cancer survival.
  
  
  METHODS
  We examined the relationship between self-reported prediagnostic use of aspirin, ibuprofen, and acetaminophen and overall survival (OS), progression-free survival (PFS), ascites at the time of primary treatment, and persistence of disease after primary treatment among 699 women diagnosed with epithelial ovarian carcinoma. The associations between use of these medications and OS and PFS were estimated using Cox proportional hazards models. We utilized unconditional logistic regression models to estimate associations between medication use and presence of ascites and persistence of disease.
  
  
  RESULTS
  Prediagnostic intake of aspirin, both low-dose and regular-dose, ibuprofen, and acetaminophen was not associated with any of the outcomes of interest.
  
  
  CONCLUSIONS
  Our results indicate a lack of association between prediagnostic intake of selected analgesics and OS, PFS, presence of ascites at the time of primary treatment, and persistence of disease after primary treatment.
  
  
  CONCLUSIONS
  Prediagnostic intake of analgesics may not be associated with ovarian cancer outcomes.
authors.affiliation: Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.
authors.forename: Albina N
authors.initials: AN
authors.lastname: Minlikeeva
authors.affiliation: Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.
authors.forename: Jo L
authors.initials: JL
authors.lastname: Freudenheim
authors.affiliation: Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona.
authors.forename: Wei-Hsuan
authors.initials: WH
authors.lastname: Lo-Ciganic
authors.affiliation: Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Kevin H
authors.initials: KH
authors.lastname: Eng
authors.affiliation: Department of Cancer Prevention and Control, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Grace
authors.initials: G
authors.lastname: Friel
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania.
authors.forename: Brenda
authors.initials: B
authors.lastname: Diergaarde
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences and Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.affiliation: Department of Cancer Prevention and Control, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Rikki
authors.initials: R
authors.lastname: Cannioto
authors.affiliation: Department of Cancer Prevention and Control, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Emily
authors.initials: E
authors.lastname: Gower
authors.affiliation: Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: J Brian
authors.initials: JB
authors.lastname: Szender
authors.affiliation: Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Kassondra
authors.initials: K
authors.lastname: Grzankowski
authors.affiliation: Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York.
authors.forename: Kunle
authors.initials: K
authors.lastname: Odunsi
authors.affiliation: School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas.
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.affiliation: Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York. Department of Cancer Prevention and Control, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York. Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York. kirsten.moysich@roswellpark.org.
authors.forename: Kirsten B
authors.initials: KB
authors.lastname: Moysich
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis
chemical_list: D000700:Analgesics