title: A pilot survey on obstetric complications in pregnant women with a history of repeated embryo implantation failure and those undergoing single local endometrial injury.
abstract: OBJECTIVE
  To assess if a history of repeated implantation failure (RIF) or local endometrial injury (LEI) for RIF affects the pregnancy course in women who conceived in the subsequent in vitro fertilization (IVF)-embryo/blastocyst transfer (ET/BT) cycle.
  
  
  METHODS
  Of 42 pregnant women with a history of three consecutive failed ET/BT cycles with negative pregnancy tests, 11 patients had a clinical pregnancy in the immediate subsequent ET/BT cycle following (the RIF group), whereas 31 patients had a clinical pregnancy in the subsequent ET/BT cycle following single curettage LEI in the proliferative phase of the preceding spontaneous cycle (the RIF/LEI group). Information on the obstetric complications were retrieved from medical records and compared with that of women who had a live birth in the first ET/BT attempt (the control group). Results: The clinical pregnancy rate, ongoing pregnancy rate, and live birth rate were significantly higher in the RIF/LEI group than in the RIF group (p < 0.010). There were no significant differences in the incidence of pregnancy of unknown location, ectopic pregnancy, miscarriage, stillbirth, preterm birth, premature rupture of the membranes, placenta previa, placental abruption, preeclampsia, pregnancy-induced hypertension, gestational diabetes, fetal growth restriction, caesarean section, and blood transfusion were similar between the three groups (p > 0.31).
  
  
  CONCLUSIONS
  In this pilot survey, neither a history of RIF nor LEI intervention for RIF increased the incidence of obstetric complications in the women who conceived in the subsequent ET/BT cycle.
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: K
authors.initials: K
authors.lastname: Kitaya
authors.forename: N
authors.initials: N
authors.lastname: Amano
authors.forename: M
authors.initials: M
authors.lastname: Kobatake
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: M
authors.initials: M
authors.lastname: Funabiki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology; D000328:Adult; D001755:Blastocyst; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000009:adverse effects*; D004717:Endometrium / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D050498:Live Birth; D010865:Pilot Projects; D010923:Placenta Previa / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D018873:Pregnancy Rate; D047928:Premature Birth / Q000453:epidemiology