title: Blood-Brain Barrier Function and Biomarkers of Central Nervous System Injury in Rickettsial Versus Other Neurological Infections in Laos.
abstract: Blood-brain barrier (BBB) function and cerebrospinal fluid (CSF) biomarkers were measured in patients admitted to hospital with severe neurological infections in the Lao People's Democratic Republic (N = 66), including bacterial meningitis (BM; N = 9) or tuberculosis meningitis (TBM; N = 11), Japanese encephalitis virus (JEV; N = 25), and rickettsial infections (N = 21) including murine and scrub typhus patients. The albumin index (AI) and glial fibrillary acidic protein (GFAP) levels were significantly higher in BM and TBM than other diseases but were also raised in individual rickettsial patients. Total tau protein was significantly raised in the CSF of JEV patients. No differences were found between clinical or neurological symptoms, AI, or biomarker levels that allowed distinction between severe neurological involvement by Orientia tsutsugamushi compared with Rickettsia species.
authors.forename: Sabine
authors.initials: S
authors.lastname: Dittrich
authors.forename: Piyanate
authors.initials: P
authors.lastname: Sunyakumthorn
authors.forename: Sayaphet
authors.initials: S
authors.lastname: Rattanavong
authors.forename: Rattanaphone
authors.initials: R
authors.lastname: Phetsouvanh
authors.forename: Phonepasith
authors.initials: P
authors.lastname: Panyanivong
authors.forename: Amphonsavanh
authors.initials: A
authors.lastname: Sengduangphachanh
authors.forename: Phonelavanh
authors.initials: P
authors.lastname: Phouminh
authors.forename: Tippawan
authors.initials: T
authors.lastname: Anantatat
authors.forename: Anisone
authors.initials: A
authors.lastname: Chanthongthip
authors.forename: Sue J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Audrey
authors.initials: A
authors.lastname: Dubot-Pérès
authors.forename: Nicholas P J
authors.initials: NPJ
authors.lastname: Day
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Paris
authors.forename: Paul N
authors.initials: PN
authors.lastname: Newton
authors.forename: Gareth D H
authors.initials: GDH
authors.lastname: Turner
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D001812:Blood-Brain Barrier / Q000378:metabolism* / Q000382:microbiology; D002490:Central Nervous System / Q000382:microbiology / Q000473:pathology / Q000821:virology; D002648:Child; D004664:Encephalitis Virus, Japanese / Q000302:isolation & purification; D004672:Encephalitis, Japanese / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007812:Laos; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D012285:Orientia tsutsugamushi / Q000302:isolation & purification; D012281:Rickettsia / Q000302:isolation & purification; D012282:Rickettsia Infections / Q000175:diagnosis*; D012612:Scrub Typhus / Q000175:diagnosis; D014390:Tuberculosis, Meningeal / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers