title: Impaired phenotype of circulating endothelial microparticles in chronic heart failure patients: Relevance to body mass index.
abstract: OBJECTIVE
  The objective of the study was to investigate the relationship of circulating endothelial-derived microparticls (EMP) pattern with body mass index (BMI) in CHF patients.
  
  
  METHODS
  The study retrospectively evolved 153 patients (86 males) who were underwent multispiral contrast-enhanced computed tomography angiography or conventional angiographic examination of coronary arteries. Flowcytometry analysis for quantifying the number of EMPs was used at baseline.
  
  
  RESULTS
  Using C-statistics for models with CHF, BMI, and circulating biomarkers (NT-pro-BNP, OPG and adiponectin) as continuous variables we found that adding of BMI to the based model (NYHA class of CHF) improved the relative IDI by 12.5% for increased CD31+/annexin V+ EMPs to CD62E+ EMPs ratio. When we used other model constructed on entering variables IDI appears to be improved up to 5.8% for increased EMPs (available for NT-pro-BNP as continuous variable). Three biomarkers (NYHA class of CHF+NT-pro-BNP+OPG) and four biomarkers (NYHA class of CHF+NT-pro-BNP+OPG+adiponectin) could not significantly improve predictive model based on combination of BMI and NYHA class of CHF for increased CD31+/annexin V+ EMPs to CD62E+ EMPs ratio.
  
  
  CONCLUSIONS
  We suggested that lower BMI is significant predictor for impaired phenotype of circulating EMPs in CHF patients.
authors.affiliation: Internal Medicine Department, State Medical University, 26, Mayakovsky Av., Zaporozhye 69035, Ukraine. Electronic address: dr_berezin@mail.ru.
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Berezin
authors.affiliation: State Medical University, Clinical Pharmacology Department, Zaporozhye, Ukraine.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Kremzer
mesh_terms: D015992:Body Mass Index; D055252:Cell-Derived Microparticles / Q000473:pathology*; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Biomarkers; Body mass index; Chronic heart failure; Endothelial-derived microparticles; Inflammation