title: Estimating the Impact of Reducing Under-Nutrition on the Tuberculosis Epidemic in the Central Eastern States of India: A Dynamic Modeling Study.
abstract: BACKGROUND
  Tuberculosis (TB) and under-nutrition are widespread in many low and middle-income countries. Momentum to prioritize under-nutrition has been growing at an international level, as demonstrated by the "Scaling Up Nutrition" movement. Low body mass index is an important risk factor for developing TB disease. The objective of this study was to project future trends in TB related outcomes under different scenarios for reducing under-nutrition in the adult population in the Central Eastern states of India.
  
  
  METHODS
  A compartmental TB transmission model stratified by body mass index was parameterized using national and regional data from India. We compared TB related mortality and incidence under several scenarios that represented a range of policies and programs designed to reduce the prevalence of under-nutrition, based on the experience and observed trends in similar countries.
  
  
  RESULTS
  The modeled nutrition intervention scenarios brought about reductions in TB incidence and TB related mortality in the Central Eastern Indian states ranging from 43% to 71% and 40% to 68% respectively, relative to the scenario of no nutritional intervention. Modest reductions in under-nutrition averted 4.8 (95% UR 0.5, 17.1) million TB cases and 1.6 (95% UR 0.5, 5.2) million TB related deaths over a period of 20 years of intervention, relative to the scenario of no nutritional intervention. Complete elimination of under-nutrition in the Central Eastern states averted 9.4 (95% UR 1.5, 30.6) million TB cases and 3.2 (95% UR 0.7-, 10.1) million TB related deaths, relative to the scenario of no nutritional intervention.
  
  
  CONCLUSIONS
  Our study suggests that intervening on under-nutrition could have a substantial impact on TB incidence and mortality in areas with high prevalence of under-nutrition, even if only small gains in under-nutrition can be achieved. Focusing on under-nutrition may be an effective way to reduce both rates of TB and other diseases associated with under-nutrition.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
authors.forename: Olivia
authors.initials: O
authors.lastname: Oxlade
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
authors.forename: Chuan-Chin
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Infectious Disease Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
authors.forename: Megan
authors.initials: M
authors.lastname: Murray
mesh_terms: D015992:Body Mass Index; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D044342:Malnutrition / Q000517:prevention & control; D008962:Models, Theoretical; D009752:Nutritional Status; D012307:Risk Factors; D015996:Survival Rate; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000401:mortality