title: Nonsyndromic Synchronous Multifocal Central Giant Cell Granulomas of the Maxillofacial Region: Report of a Case.
abstract: Central giant cell granuloma (CGCG) is a benign proliferation of fibroblasts and multinucleated giant cells that almost exclusively occurs in the jaws. It commonly occurs in young adults showing a female predilection in the anterior mandible. Multifocal CGCGs in maxillofacial region are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as Noonan-like multiple giant cell lesion syndrome or other disorders. Only 10 cases of multifocal CGCGs in the maxillofacial region without any concomitant systemic disease have been reported in the English literature. Here, we report an unusual case of 36 year-old female presented with non-syndromic synchronous, multifocal CGCGs in the left posterior mandible and left posterior maxilla without any concomitant systemic disease. Relevant literature is reviewed and the incidence, clinical features, radiological features, differential diagnosis and management of CGCGs are discussed.
authors.affiliation: Professor, Department of Oral Medicine Radiology,Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
authors.forename: Anita
authors.initials: A
authors.lastname: Munde
authors.affiliation: Post Graduate Student, Department of Oral Medicine and Radiology, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Modi
authors.affiliation: Professor, Department of Pathology,Rural Medical College,Pravara Institute of MedicalSciences, Loni, Maharashtra, India.
authors.forename: Ravindra
authors.initials: R
authors.lastname: Karle
authors.affiliation: Assistant Professor, Department of Oral Medicine and Radiology,Rural Dental College,Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
authors.forename: Pranali
authors.initials: P
authors.lastname: Wankhede
authors.affiliation: Professor, Department of Oral Medicine and Radiology, Rural Dental College,Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
authors.forename: Safia
authors.initials: S
authors.lastname: Shoeb
keywords: Central giant cell granuloma; Mandible; Maxilla; Multifocal