title: High-capacity magnetic hollow porous molecularly imprinted polymers for specific extraction of protocatechuic acid.
abstract: Magnetic hollow porous molecularly imprinted polymers (HPMIPs) with high binding capacity, fast mass transfer, and easy magnetic separation have been fabricated for the first time. In this method, HPMIPs was firstly synthesized using protocatechuic acid (PCA) as template, 4-vinylpyridine (4-VP) as functional monomer, glycidilmethacrylate (GMA) as co-monomer, and MCM-48 as sacrificial support. After that, epoxide ring of GMA was opened for chemisorbing Fe3O4 nanoparticles to prepare magnetic HPMIPs. The results of characterization indicated that magnetic HPMIPs exhibited large surface area (548m(2)/g) with hollow porous structure and magnetic sensitivity (magnetic saturation at 2.9emu/g). The following adsorption characteristics investigation exhibited surprisingly higher adsorption capacity (37.7mg/g), and faster kinetic binding (25min) than any previously reported PCA imprinted MIPs by traditional or surface imprinting technology. The equilibrium data fitted well to Langmuir equation and the adsorption process could be described by pseudo-second order model. The selective recognition experiments also demonstrated the high selectivity of magnetic HPMIPs towards PCA over analogues. The results of the real sample analysis confirmed the superiority of the proposed magnetic HPMIPs for selective and efficient enrichment of trace PCA from complex matrices.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Electronic address: shuyshi@gmail.com.
authors.forename: Shuyun
authors.initials: S
authors.lastname: Shi
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Jiang
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. Electronic address: xqchen@csu.edu.cn.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D062385:Hydroxybenzoates / Q000302:isolation & purification*; D007700:Kinetics; D060328:Magnetic Phenomena; D054802:Molecular Imprinting; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D016062:Porosity
chemical_list: D062385:Hydroxybenzoates; D011108:Polymers; C009091:protocatechuic acid
keywords: Complex matrices; Hollow porous structure; Magnetic separation; Molecularly imprinted polymers; Protocatechuic acid