title: Selenium Catalyzed Oxidation of Aldehydes: Green Synthesis of Carboxylic Acids and Esters.
abstract: The stoichiometric use of hydrogen peroxide in the presence of a selenium-containing catalyst in water is here reported as a new ecofriendly protocol for the synthesis of variously functionalized carboxylic acids and esters. The method affords the desired products in good to excellent yields under very mild conditions starting directly from commercially available aldehydes. Using benzaldehyde as a prototype the gram scale synthesis of benzoic acid is described, in which the aqueous medium and the catalyst could be recycled at last five times while achieving an 87% overall yield.
authors.affiliation: Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy. sancineto.luca@gmail.com.
authors.forename: Luca
authors.initials: L
authors.lastname: Sancineto
authors.affiliation: Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy. caterinatidei@libero.it.
authors.forename: Caterina
authors.initials: C
authors.lastname: Tidei
authors.affiliation: Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy. luana.bagnoli@unipg.it.
authors.forename: Luana
authors.initials: L
authors.lastname: Bagnoli
authors.affiliation: Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy. francesca.marini@unipg.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Marini
authors.affiliation: Laboratório de Síntese Orgânica Limpa (LASOL), Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, Brazil. lenardao@ufpel.edu.br.
authors.forename: Eder J
authors.initials: EJ
authors.lastname: Lenardão
authors.affiliation: Group of Catalysis and Organic Green Chemistry, Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy. claudio.santi@unipg.it.
authors.forename: Claudio
authors.initials: C
authors.lastname: Santi
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis; D055772:Green Chemistry Technology; D010084:Oxidation-Reduction; D012643:Selenium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D004952:Esters; D012643:Selenium
keywords: aldehydes; carboxylic acids; catalysis; esters; green chemistry; hydrogen peroxide; oxidation; selenium