title: Primary lymphoepithelioma-like hepatocellular carcinoma: report of a locally advanced case and review of literature.
abstract: Lymphoepithelioma-like hepatocellular carcinoma is rare, which has been recognized as a variant of hepatocellular carcinoma. Here we report a locally advanced case of lymphoepithelioma-like hepatocellular carcinoma. A 50-year-old man with chronic hepatitis B virus infection presented with a single mass in the liver and two enlarged lymph nodes in retroperitoneum suspected to be hepatocellular carcinoma with lymph node metastasis. After discussion by multidisciplinary team, the patient underwent hepatectomy of VIII segment and dissection of two enlarged lymph nodes. One month after the operation, pre-chemotherapy abdominal computed tomography (CT) showed retroperitoneal enlarged lymph nodes, considered as local recurrence. Therefore, 3 cycles of oxaliplatin and tegafur gimeracil oteracil potassium capsule and 3 cycles of paclitaxel and cisplatin were offered, and post-chemotherapy abdominal CT revealed disease remained stable. The patient has been alive for 6 months since performance of surgery. Our report suggests that even locally advanced lymphoepithelioma-like hepatocellular carcinoma may have a good prognosis and operation and postoperative chemotherapy may benefit the patient.
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, The 9th Clinical Medical College of Peking University and Clinical Cancer Center of Capital Medical University China.
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: An
authors.affiliation: Department of Hepatobiliary Surgery, China-Japan Friendship Hospital China.
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: Liu
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Zheng
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: Rong
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Wang
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Fa-Qiang
authors.initials: FQ
authors.lastname: Liu
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Fei
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Abdominal Surgery, Cancer Hospital Chinese Academy of Medical Sciences China.
authors.forename: Jian-Xiong
authors.initials: JX
authors.lastname: Wu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000628:therapy / Q000821:virology; D003131:Combined Modality Therapy; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged
keywords: Hepatocellular carcinoma; hepatectomy; lymphoepithelioma-like carcinoma