title: Effectiveness of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: an echocardiographic study of left ventricular remodeling.
abstract: OBJECTIVE
  The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. The aim of this study was to evaluate the effectiveness of isolated coronary artery bypass graft combined with bone marrow mononuclear cells (BMMNC) delivered through graft vessels to improve left ventricular remodeling of patients with previous myocardial infarction and chronic heart failure using echocardiography.
  
  
  METHODS
  Patients with previous myocardial infarction and chronic heart failure were randomly allocated to one of the two groups: CABG only (18 patients), or CABG with BMMNC transplantation (24 patients). Echocardiographic parameters were measured on B-mode imaging, 3D imaging and color flow imaging. RESULTS Post-operative LVEDD (end-diastolic dimension of left ventricle), LVESD (end-systolic dimension of left ventricle), LVEDV (end-diastolic volume of left ventricle), LVESV (end-systolic volume of left ventricle), LVEDVI (LVEDV indexed to body surface area), LVESVI (LVESV indexed to body surface area), LV-mass (mass of left ventricle) and LV-massI (LV-mass indexed to body surface area) were significantly improved compared with those obtained prior to operation in CABG+BMMNC group (al p<0.05). The same parameters were not significantly different pre- and postoperative in the CABG group (al p>0.05). Postoperative mitral regurgitation score was not significantly different from those prior to operation in both groups (al p>0.05). In Chi-square tests, LVEDD, LVESD, LVEDV, LVESV, LVEDVI, LVESVI, LV-mass, LV-massI were determinants of the left ventricular remodeling.
  
  
  CONCLUSIONS
  The improvement of left ventricular remodeling in CABG+BMMNC group was better than in the CABG group and this improvement was verified by echocardiography.
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Fujian
authors.initials: F
authors.lastname: Duan
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Qi
authors.affiliation: Department of Cardiovascular Surgery, Fuwai Hospital & Cardiovascular Institute, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Xiuzhang
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China. fuwaiwanghao@126.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Echocardiography, Chinese Academy of Medical Sciences & Tsinghua University, Peking Union Medical College, Beijing, China.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Wang
mesh_terms: D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D001026:Coronary Artery Bypass; D005260:Female; D006333:Heart Failure / Q000601:surgery*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery*; D016896:Treatment Outcome; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000502:physiology*