title: Pasta containing tartary buckwheat sprouts prevents DNA damage in spontaneously hypertensive rats.
abstract: Recent studies have shown that DNA damage occurs more often in hypertensive patients than non-hypertensive individuals. Here, we analyzed the in vivo effect of pasta containing 30% of tartary buckwheat sprouts (TBSP) on spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (WKY) to elucidate if TBSP could have an anti-genotoxic effect in hypertensive animal models. Both SHRs and WKY rats were divided into two groups and fed for six weeks with 5 g of TBSP and durum wheat flour commercial pasta, respectively. Our results showed that a diet rich in TBSP has anti-genotoxic effect. Indeed, SHRs fed with TBSP exhibited a significant decrease in DNA damage (38%) and more efficient DNA repair (84%) compared to SHRs fed with commercial pasta.
authors.affiliation: Department of Ecological and Biological Sciences (DEB), Laboratory of Cellular and Molecular Nutrition, Tuscia University , Viterbo , Italy and.
authors.forename: Roberta
authors.initials: R
authors.lastname: Meschini
authors.forename: Silvia
authors.initials: S
authors.lastname: Filippi
authors.forename: Romina
authors.initials: R
authors.lastname: Molinari
authors.forename: Lara
authors.initials: L
authors.lastname: Costantini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bonafaccia
authors.forename: Nicolò
authors.initials: N
authors.lastname: Merendino
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D004032:Diet; D019612:Fagopyrum / Q000737:chemistry; D005433:Flour / Q000032:analysis; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018520:Plant Shoots / Q000737:chemistry; D011794:Quercetin / Q000494:pharmacology; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012431:Rutin / Q000494:pharmacology; D012639:Seeds; D014908:Triticum
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D010936:Plant Extracts; D012431:Rutin; D004247:DNA; D011794:Quercetin
keywords: Antioxidants; DNA damage; DNA oxidative damage; functional food; phenols