title: Human serum biomarker detection based on a cascade signal amplification strategy by a DNA molecule machine.
abstract: A convenient method is presented that employs a DNA machine for protein biomarker detection. The detection limit is 400 times lower compared to the method without a DNA machine. This study provides a promising method that could realize most protein biomarker detections without the corresponding aptamers, using a DNA machine for signal amplification.
authors.affiliation: School of Chemistry and Chemical Engineering of Linyi University, Linyi 276005, P. R. China. shushzhang@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xin
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.forename: Shusheng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D017430:Prostate-Specific Antigen / Q000097:blood; D013050:Spectrometry, Fluorescence
chemical_list: D052157:Aptamers, Nucleotide; D015415:Biomarkers; D004247:DNA; D017430:Prostate-Specific Antigen