title: miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas.
abstract: The aim of this study was to compare the clinicopathological significance of miR-200a/miR-141 and miR-205 expression in endometrioid carcinomas (ECs) versus nonendometrioid carcinomas (NECs) and to assess their correlation with hormone receptor status. miR-200a/miR-141 and miR-205 expression in 154 endometrial cancers was determined by qRT-PCR. The status of estrogen and progesterone receptor (ER/PR) was assessed using immunohistochemistry. miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. The expression level of miR-200a was significantly higher in NECs than in ECs (P=0.025). Furthermore, there was a trend that NECs with worse clinicopathological variables had a higher miR-200a expression, while an inverse trend existed in ECs. miR-205 upregulation occurred frequently in NECs without lymph node metastases (P=0.030), whereas such association was not present in ECs. Interestingly, In ECs, miR-200a/miR-141 upregulation occurred frequently in the hormone receptor positive subgroups than the negative subgroups (P<0.05). Similarly, the expression level of miR-205 was higher in the hormone receptor positive subgroups and the association between miR-205 and PR reached statistical significance (P=0.024). In contrast, in NECs, a negative correlation was found between miR-200a/miR-141 and ER or PR status. Meanwhile, in ECs, miR-200a upregulation correlated with prolonged survival in the ER positive subgroup (P=0.046), whereas an inverse trend existed in the ER negative subgroup. Our findings suggest that miR-200a/miR-141 and miR-205 increased significantly in ECs and in NECs. However, they might behave differently in ECs versus NECs. miR-200a/miR-141 and miR-205 might be associated with hormone receptor status in endometrial cancer and may possess prognostic impacts.
authors.affiliation: Department of Pathology, Peking University First Hospital Beijing, China ; Department of Pathology, Xinjiang Medical University, Cancer Hospital Urumqi, Xinjiang Uygur Autonomous Region, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Pathology, Peking University First Hospital Beijing, China.
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Si
authors.affiliation: Department of Pathology, Xinjiang Medical University, Cancer Hospital Urumqi, Xinjiang Uygur Autonomous Region, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Li
authors.affiliation: Department of Pathology, Peking University First Hospital Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Gynecology and Obstetrics, Peking University First Hospital Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Xinjiang Medical University, Cancer Hospital Urumqi, Xinjiang Uygur Autonomous Region, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Peking University First Hospital Beijing, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Pathology, Peking University First Hospital Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics / Q000401:mortality; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D011960:Receptors, Estrogen / Q000096:biosynthesis / Q000235:genetics; D011980:Receptors, Progesterone / Q000096:biosynthesis / Q000235:genetics; D015854:Up-Regulation
chemical_list: D035683:MicroRNAs; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C533895:MIRN141 microRNA, human; C533896:MIRN200 microRNA, human; C534425:MIR205, human
keywords: ER; Endometrial carcinoma; PR; miR-200a/miR-141; miR-205