title: Chemical Platforms for Peptide Vaccine Constructs.
abstract: Knowledge of the sequences and structures of proteins from pathogenic microorganisms has been put to great use in the field of protein chemistry for the development of peptide-based vaccines. These vaccine constructs include chemically tailored, shorter peptidic fragments that can induce high immunogenicity, thus shunning the allergenic and nonimmunogenic part of the antigens. Based on this concept, several different chemistries have been pursued to obtain novel platforms onto which antigenic epitopes can be tethered, with the aim to achieve a higher antibody response. In this regard, here we attempt to summarize the chemical strategies developed for the presentation of peptide epitopes.
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Suhas
authors.initials: S
authors.lastname: Ramesh
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Prabhakar
authors.initials: P
authors.lastname: Cherkupally
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Thavendran
authors.initials: T
authors.lastname: Govender
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Hendrik G
authors.initials: HG
authors.lastname: Kruger
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; School of Chemistry, Yachay Tech, Yachay City of Knowledge, Urcuqui, Ecuador; School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Barcelona, Spain; Department of Organic Chemistry, University of Barcelona, Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; School of Chemistry, Yachay Tech, Yachay City of Knowledge, Urcuqui, Ecuador. Electronic address: beatriz.garcia@upf.edu.
authors.forename: Beatriz G
authors.initials: BG
authors.lastname: de la Torre
mesh_terms: D016915:AIDS Vaccines / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D006678:HIV / Q000276:immunology*; D007252:Influenza Vaccines / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D009975:Orthomyxoviridae / Q000276:immunology*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D007252:Influenza Vaccines; D010455:Peptides; D014614:Vaccines, Synthetic
keywords: Chemical approaches; MAPs; Peptide epitopes; Synthesis; Vaccine