title: Human adenovirus type 8 epidemic keratoconjunctivitis with large corneal epithelial full-layer detachment: an endemic outbreak with uncommon manifestations.
abstract: Epidemic viral conjunctivitis is a highly contagious disease that is encountered year-round. The causative agents are mainly adenoviruses and enteroviruses. It occurs most commonly upon infection with subgroup D adenoviruses of types 8, 19, or 37. For common corneal involvement of human adenovirus type 8 epidemic keratoconjunctivitis, full-layer epithelial detachment is rarely seen. Herein, we report three cases of epidemic keratoconjunctivitis during an outbreak which manifested as large corneal epithelial full-layer detachment within a few days. The lesions healed without severe sequelae under proper treatment. The unique manifestation of this outbreak may indicate the evolution of human adenovirus type 8.
authors.affiliation: Department of Ophthalmology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
authors.forename: Yueh-Chang
authors.initials: YC
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
authors.forename: Nancy
authors.initials: N
authors.lastname: Chen
authors.affiliation: Taiwan CDC Collaborating Laboratories of Virology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ; Department of Laboratory Medicine, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ; Graduate Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan.
authors.forename: I-Tsong
authors.initials: IT
authors.lastname: Huang
authors.affiliation: Taiwan CDC Collaborating Laboratories of Virology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Yang
authors.affiliation: Department of Ophthalmology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
authors.forename: Chin-Te
authors.initials: CT
authors.lastname: Huang
authors.affiliation: Taiwan CDC Collaborating Laboratories of Virology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ; Department of Laboratory Medicine, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ; Graduate Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan ; Department of Laboratory Diagnosis, Tzu-Chi University, Hualien, Taiwan.
authors.forename: Li-Kuang
authors.initials: LK
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ; Department of Ophthalmology and Visual Science, Tzu-Chi University, Hualien, Taiwan ; Department of Ophthalmology, Mennonite Christian Hospital, Hualien, Taiwan.
authors.forename: Min-Muh
authors.initials: MM
authors.lastname: Sheu
keywords: EKC; HAdV-8; cornea; epidemic viral conjunctivitis; virology