title: Tissue Blood Flow During Remifentanil Infusion With Carbon Dioxide Loading.
abstract: The aim of this study was to investigate the effect of changes in end-tidal carbon dioxide tension (ETCO2) during remifentanil (Remi) infusion on oral tissue blood flow in rabbits. Eight male tracheotomized Japan White rabbits were anesthetized with sevoflurane under mechanical ventilation. The infusion rate of Remi was 0.4 μg/kg/min. Carbon dioxide was added to the inspired gas to change the inspired CO2 tension to prevent changes in the ventilating condition. Observed variables were systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), common carotid artery blood flow (CCBF), tongue mucosal blood flow (TBF), mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF). The CCBF, TBF, BBF, UBF, and LBF values were increased, while MBF was decreased, under hypercapnia, and vice versa. The BBF, UBF, and LBF values were increased, while the MBF value was decreased, under hypercapnia during Remi infusion, and vice versa. The BBF, MBF, UBF, and LBF values, but not the CCBF and TBF values, changed along with ETCO2 changes during Remi infusion.
authors.affiliation: Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kanbe
authors.affiliation: Senior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuura
authors.affiliation: Senior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Masataka
authors.initials: M
authors.lastname: Kasahara
authors.affiliation: Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ichinohe
mesh_terms: D000539:Alveolar Process / Q000098:blood supply; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D062186:Arterial Pressure / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001853:Bone Marrow / Q000098:blood supply; D019296:Capnography / Q000379:methods; D002245:Carbon Dioxide / Q000008:administration & dosage; D017536:Carotid Artery, Common / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006935:Hypercapnia / Q000503:physiopathology*; D008297:Male; D008334:Mandible / Q000098:blood supply; D008406:Masseter Muscle / Q000098:blood supply; D009055:Mouth / Q000098:blood supply*; D010880:Piperidines / Q000008:administration & dosage*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D000077208:Remifentanil; D012121:Respiration, Artificial / Q000379:methods; D014059:Tongue / Q000098:blood supply; D014139:Tracheostomy / Q000379:methods
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D002245:Carbon Dioxide; D000077208:Remifentanil
keywords: End-tidal carbon dioxide; Hypercapnia; Hypocapnia; Oral tissue blood flow; Remifentanil