title: Platelet-Rich Plasma and Deproteinized Bovine Bone Matrix in Maxillary Sinus Lift Surgery: A Split-Mouth Histomorphometric Evaluation.
abstract: OBJECTIVE
  The purpose of this split-mouth controlled study was to evaluate and compare the amount of vital bone after lateral sinus lift surgery using either a mixture of pure platelet concentrate and deproteinized bovine bone mineral (test group) or solely deproteinized bovine bone as grafting material (control group).
  
  
  METHODS
  Six patients with edentulous posterior maxilla and a residual ridge height of less than 4 mm were recruited in this study. Six months after grafting procedure, 2 bone biopsies per patient were taken bilaterally from the anterolateral sinus wall. Histological and histomorphometrical analysis was carried out.
  
  
  RESULTS
  A total of 10 sinus surgeries in 5 patients were analyzed. The mean percentage of vital bone was 22.72% ± 9.21% (range, 11.45%-33.30%) in the control group and 30.70% ± 7.89% (range, 18.30%-39.99%) in the test group.
  
  
  CONCLUSIONS
  The adjunct of pure platelet-rich plasma to deproteinized bovine bone mineral may enhance vital bone formation in the first 6 months after sinus floor augmentation. However, no statistically significant difference was found between groups (P = 0.18).
authors.affiliation: *Academic Researcher, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Health Research Centre, Milan, Italy. †Visiting Professor, Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Milan, Italy. ‡Visiting Professor, Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Implantology Research Centre, Milan, Italy. §Full Professor, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Head of Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Member Oral Health Research Centre, Milan, Italy. ¶Associate Professor, Director Oral Implantology Research Centre, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Department of Biomedical, Surgical and Dental Sciences, Director Oral Implantology Research Centre, Milan, Italy. ‖Visiting Professor, Department of Health, Animal Science and Food Safety, Milan, Italy. #Associate Professor, Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy; Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; Università degli Studi di Milano, Director Oral Health Research Centre, Milan, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Taschieri
authors.forename: Tiziano
authors.initials: T
authors.lastname: Testori
authors.forename: Stefano
authors.initials: S
authors.lastname: Corbella
authors.forename: Roberto
authors.initials: R
authors.lastname: Weinstein
authors.forename: Luca
authors.initials: L
authors.lastname: Francetti
authors.forename: Alessia
authors.initials: A
authors.lastname: Di Giancamillo
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Fabbro
mesh_terms: D000368:Aged; D000818:Animals; D001706:Biopsy; D001857:Bone Matrix / Q000378:metabolism*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D054893:Cone-Beam Computed Tomography; D003758:Dental Implantation, Endosseous / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053657:Platelet-Rich Plasma / Q000378:metabolism*; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D018786:Bone Substitutes