title: Influence of mussels (Mytilus galloprovincialis) from polluted and non-polluted areas on some atherosclerosis indices in rats fed cholesterol.
abstract: The influence of diets supplemented with mussels, from polluted (MPoll) and non-polluted (MNPoll) areas, on some atherosclerosis indices in rats fed cholesterol (Chol) were studied. According to the results of our investigation in vitro, mussels from polluted areas had higher contents of proteins, metals and antioxidant compounds, mostly phenolics and higher antioxidant capacities. 28 male Wistar rats were divided into 4 groups of 7 and named Control, Chol, Chol/MPoll and Chol/MNPoll. The rats of the Control group received basal diet (BD) only, and the diets of the other 3 groups were supplemented with 1% of non-oxidized cholesterol (NOC), 1% of NOC and 5.6% of mussel dry matter (DM) from polluted and 1% of NOC and 5.6% of mussel DM from non-polluted areas for Chol, Chol/MPoll and Chol/MNPoll, respectively. The histology of the aorta and brain in rats fed cholesterol did not show any signs of atherosclerosis. Some differences were registered in the electrophoretic protein patterns of plasma in rats, with mussel-supplemented diets. In full plasma electrophoretic patterns of the Chol/MPoll diet group more proteins were detected than in both Chol and Control groups, and the differences were significant. In conclusion, in groups of rats fed cholesterol with mussels supplementation, a significant hindering in the rise of plasma lipid levels and also hindering in the decrease of plasma antioxidant activity were registered.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Hadassah Medical School, P.O. Box 12065, Jerusalem 91120, Israel. Electronic address: gorin@cc.huji.ac.il.
authors.forename: Shela
authors.initials: S
authors.lastname: Gorinstein
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Leontowicz
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Leontowicz
authors.affiliation: Chemical Faculty, Gdansk University of Technology, Gdansk 80952, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Namiesnik
authors.affiliation: National Medicines Institute, 00-725 Warsaw, Poland.
authors.forename: Zenon
authors.initials: Z
authors.lastname: Jastrzebski
authors.affiliation: Plant Breeding and Acclimatization Institute, Radzikow, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Drzewiecki
authors.affiliation: Department of Horticultural Science, Mokpo National University, Muan Jeonnam 534-729, South Korea.
authors.forename: Yong-Seo
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of Food Engineering, Mokpo National University, Muan Jeonnam 534-729, South Korea.
authors.forename: Kyung-Sik
authors.initials: KS
authors.lastname: Ham
authors.affiliation: Naju Foundation of Natural Dyeing Culture, Naju 520-931, South Korea.
authors.forename: Buk-Gu
authors.initials: BG
authors.lastname: Heo
authors.affiliation: Kaplan University Medical Center, Rehovot, Israel.
authors.forename: Simon
authors.initials: S
authors.lastname: Trakhtenberg
keywords: Atherosclerosis indices; Electrophoresis; Mussels; Polluted and non-polluted areas; Rats