title: Synthesis of bio-based thermoplastic polyurethane elastomers containing isosorbide and polycarbonate diol and their biocompatible properties.
abstract: A new family of highly elastic polyurethanes (PUs) partially based on renewable isosorbide were prepared by reacting hexamethylene diisocyanate with a various ratios of isosorbide and polycarbonate diol 2000 (PCD) via a one-step bulk condensation polymerization without catalyst. The influence of the isorsorbide/PCD ratio on the properties of the PU was evaluated. The successful synthesis of the PUs was confirmed by Fourier transform-infrared spectroscopy and (1)H nuclear magnetic resonance. The resulting PUs showed high number-average molecular weights ranging from 56,320 to 126,000 g mol(-1) and tunable Tg values from -34 to -38℃. The thermal properties were determined by differential scanning calorimetry and thermogravimetric analysis. The PU films were flexible with breaking strains from 955% to 1795% at from 13.5 to 54.2 MPa tensile stress. All the PUs had 0.9-2.8% weight lost over 4 weeks and continual slow weight loss of 1.1-3.6% was observed within 8 weeks. Although the cells showed a slight lower rate of proliferation than that of the tissue culture polystyrene as a control, the PU films were considered to be cytocompatible and nontoxic. These thermoplastic PUs were soft, flexible and biocompatible polymers, which open up a range of opportunities for soft tissue augmentation and regeneration.
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.
authors.forename: So-Yeon
authors.initials: SY
authors.lastname: Oh
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea.
authors.forename: Min-Sil
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
authors.affiliation: Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center, Dankook University Graduate School, Chungnam, South Korea msgong@dankook.ac.kr.
authors.forename: Myoung-Seon
authors.initials: MS
authors.lastname: Gong
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D020724:Elastomers / Q000138:chemical synthesis*; D007547:Isosorbide / Q000737:chemistry*; D051379:Mice; D011076:Polycarboxylate Cement / Q000737:chemistry*; D011140:Polyurethanes / Q000138:chemical synthesis*; D066244:Proton Magnetic Resonance Spectroscopy; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D020724:Elastomers; D011076:Polycarboxylate Cement; D011140:Polyurethanes; C005506:polycarbonate; D007547:Isosorbide
keywords: Isosorbide; biocompatibility; poly(carbonate diol); polyurethane; thermoplastic elastomer