title: New Anti-Fibrotic Drug Candidates from Mangrove-Derived Streptomyces xiamenensis Suppressing Local Inflammation and Mechanical Stress in Hypertrophic Scars.
authors.affiliation: 1] State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [2] Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Key Laboratory of Systems Biomedicine, Shanghai, China.
authors.forename: Min-Juan
authors.initials: MJ
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Microbial Metabolism and School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000627:therapeutic use*; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology; D005355:Fibrosis; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D012867:Skin / Q000473:pathology*; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism*; D013314:Stress, Mechanical; D013329:Structure-Activity Relationship; D013912:Threonine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use; D053833:Wetlands
chemical_list: D001578:Benzopyrans; C582113:N-((3,4-dihydro-3-hydroxy-2-methyl-2-(4'-methyl-3'-pentenyl)-2H-1-benzopyran-6-yl)carbonyl)threonine; D013912:Threonine