title: Hepatic Transcriptome Responses in Mice (Mus musculus) Exposed to the Nafion Membrane and Its Combustion Products.
abstract: Nafion 117 membrane (N117), an important polymer electrolyte membrane (PEM), has been widely used for numerous chemical technologies. Despite its increasing production and use, the toxicity data for N117 and its combustion products remain lacking. Toxicity studies are necessary to avoid problems related to waste disposal in landfills and incineration that may arise. In this study, we investigated the histopathological alterations, oxidative stress biomarker responses, and transcriptome profiles in the liver of male mice exposed to N117 and its combustion products for 24 days. An ion-chromatography system and liquid chromatography system coupled to a hybrid quadrupole time-of-flight mass spectrometry were used to analyze the chemical compositions of these combustion products. The transcriptomics analysis identified several significantly altered molecular pathways, including the metabolism of xenobiotics, carbohydrates and lipids; signal transduction; cellular processes; immune system; and signaling molecules and interaction. These studies provide preliminary data for the potential toxicity of N117 and its combustion products on living organisms and may fill the information gaps in the toxicity databases for the currently used PEMs.
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
authors.forename: Mingbao
authors.initials: M
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
authors.forename: Ruijuan
authors.initials: R
authors.lastname: Qu
authors.affiliation: College of Agricultural and Environmental Sciences, Department of Crop and Soil Sciences, University of Georgia, Griffin, Georgia 30223, United States of America.
authors.forename: Mussie
authors.initials: M
authors.lastname: Habteselassie
authors.affiliation: College of Resources and Environmental Science, Nanjing Agriculture University, Nanjing 210046, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
authors.forename: Shaogui
authors.initials: S
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: College of Agricultural and Environmental Sciences, Department of Crop and Soil Sciences, University of Georgia, Griffin, Georgia 30223, United States of America.
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, P. R. China.
authors.forename: Zunyao
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D005465:Fluorocarbon Polymers / Q000737:chemistry / Q000633:toxicity*; D006256:Hazardous Waste; D017745:Incineration; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008567:Membranes, Artificial; D051379:Mice; D018384:Oxidative Stress; D059467:Transcriptome
chemical_list: D005465:Fluorocarbon Polymers; D006256:Hazardous Waste; D008567:Membranes, Artificial; C040402:perfluorosulfonic acid