title: Relationship Between Pattern Electroretinogram, Frequency-Domain OCT, and Automated Perimetry in Chronic Papilledema From Pseudotumor Cerebri Syndrome.
abstract: OBJECTIVE
  We evaluated the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes with visual field (VF) loss and resolved papilledema from pseudotumor cerebri syndrome (PTC) and controls, to compare PERG and optical coherence tomography (OCT) with regard to discrimination ability, and to assess the correlation between PERG, frequency domain OCT (FD-OCT), and VF measurements.
  
  
  METHODS
  The VFs and full-field stimulation PERGs based on 48 and 14-min checks were obtained from patients with PTC (n = 24, 38 eyes) and controls (n = 26, 34 eyes). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and correlation coefficients were determined.
  
  
  RESULTS
  Compared to controls, PERG N95 and P50+N95 amplitude measurements with 48-minute checks were significantly reduced in eyes with resolved papilledema from PTC. Both PERG N95 amplitude and OCT parameters were able to discriminate papilledema eyes from controls with a similar performance. Significant correlations, ranging from 0.25 (P < 0.05) to 0.43 (P < 0.01) were found between PERG amplitude values and OCT-measured macular ganglion cell layer thickness, RNFL thickness, and total retinal thickness. The PERG amplitude also was significantly associated with VF sensitivity loss with correlation coefficients ranging from 0.24 (P < 0.05) and 0.35 (P < 0.01).
  
  
  CONCLUSIONS
  The PERG measurements were able to detect neural loss in PTC eyes with resolved papilledema and were reasonably well correlated with OCT measurements and VF parameters. Thus, PERG may be a useful tool in the monitoring of retinal neural loss in eyes with active papilledema from PTC.
authors.affiliation: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33) University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Clara L
authors.initials: CL
authors.lastname: Afonso
authors.affiliation: Department of Psychology, Columbia University, New York, New York, United States 3Department of Neurobiology and Behavior, Columbia University, New York, New York, United States.
authors.forename: Ali S
authors.initials: AS
authors.lastname: Raza
authors.affiliation: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33) University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: André C
authors.initials: AC
authors.lastname: Kreuz
authors.affiliation: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33) University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hokazono
authors.affiliation: Department of Ophthalmology, Federal University of Juiz de Fora, Minas Gerais, Brazil.
authors.forename: Leonardo P
authors.initials: LP
authors.lastname: Cunha
authors.affiliation: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33) University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Maria K
authors.initials: MK
authors.lastname: Oyamada
authors.affiliation: Division of Ophthalmology and Laboratory of Investigation in Ophthalmology (LIM 33) University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Mário L R
authors.initials: ML
authors.lastname: Monteiro
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D010211:Papilledema / Q000175:diagnosis* / Q000209:etiology*; D011446:Prospective Studies; D011559:Pseudotumor Cerebri / Q000150:complications*; D041623:Tomography, Optical Coherence; D058609:Visual Field Tests