title: Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories.
abstract: Traumatic brain injury (TBI) is a major public health issue exacting a substantial personal and economic burden globally. With the advent of "big data" approaches to understanding complex systems, there is the potential to greatly accelerate knowledge about mechanisms of injury and how to detect and modify them to improve patient outcomes. High quality, well-defined data are critical to the success of bioinformatics platforms, and a data dictionary of "common data elements" (CDEs), as well as "unique data elements" has been created for clinical TBI research. There is no data dictionary, however, for preclinical TBI research despite similar opportunities to accelerate knowledge. To address this gap, a committee of experts was tasked with creating a defined set of data elements to further collaboration across laboratories and enable the merging of data for meta-analysis. The CDEs were subdivided into a Core module for data elements relevant to most, if not all, studies, and Injury-Model-Specific modules for non-generalizable data elements. The purpose of this article is to provide both an overview of TBI models and the CDEs pertinent to these models to facilitate a common language for preclinical TBI research.
authors.affiliation: 1 Department of Neurosurgery, University of Pennsylvania , Philadelphia, Pennsylvania.
authors.forename: Douglas H
authors.initials: DH
authors.lastname: Smith
authors.affiliation: 2 One Mind, Seattle, Washington.|3 National Institutes of Health, National Institute of Neurological Disorders and Stroke , Bethesda, Maryland.
authors.forename: Ramona R
authors.initials: RR
authors.lastname: Hicks
authors.affiliation: 1 Department of Neurosurgery, University of Pennsylvania , Philadelphia, Pennsylvania.
authors.forename: Victoria E
authors.initials: VE
authors.lastname: Johnson
authors.affiliation: 3 National Institutes of Health, National Institute of Neurological Disorders and Stroke , Bethesda, Maryland.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Bergstrom
authors.affiliation: 3 National Institutes of Health, National Institute of Neurological Disorders and Stroke , Bethesda, Maryland.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Cummings
authors.affiliation: 4 Department of Neurological Surgery, University of California , San Francisco, San Francisco, California.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Noble
authors.affiliation: 5 Department of Neurosurgery, University of California Los Angeles , Los Angeles, California.
authors.forename: David
authors.initials: D
authors.lastname: Hovda
authors.affiliation: 6 Department of Pediatrics, Neuroscience Center at Massachusetts General Hospital , Charlestown, Massachusetts.
authors.forename: Michael
authors.initials: M
authors.lastname: Whalen
authors.affiliation: 7 Operational & Undersea Medicine Directorate, Naval Medical Research Center , Silver Spring, Maryland.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Ahlers
authors.affiliation: 8 Department of Biomedical Engineering, Georgia Tech and Emory University , Atlanta, Georgia .
authors.forename: Michelle
authors.initials: M
authors.lastname: LaPlaca
authors.affiliation: 9 Walter Reed Army Institute of Research , Silver Spring, Maryland.
authors.forename: Frank C
authors.initials: FC
authors.lastname: Tortella
authors.affiliation: 10 Department of Neurosurgery, Harvard Medical School , Boston, Massachusetts.
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Duhaime
authors.affiliation: 11 Department of Neurological Surgery, University of Pittsburgh , Pittsburgh, Pennsyvania.
authors.forename: C Edward
authors.initials: CE
authors.lastname: Dixon
mesh_terms: D000818:Animals; D001753:Blast Injuries / Q000473:pathology; D020201:Brain Hemorrhage, Traumatic / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology; D065709:Common Data Elements; D019295:Computational Biology; D016208:Databases, Factual; D006801:Humans; D007753:Laboratories; D015201:Meta-Analysis as Topic; D023421:Models, Animal; D008959:Models, Neurological; D011634:Public Health; D012015:Reference Standards
keywords: common data elements; data dictionary; pre-clinical TBI models; traumatic brain injury