title: Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese.
abstract: BACKGROUND
  Nuclear factor kappa B (NF-κB) pathway proteins play an important role in modulating inflammation and other carcinogenic processes. Polymorphisms within NF-κB pathway genes may influence cancer risk. This study aimed to examine the association between NFKB19-4 ATTG ins→del, NFKBIA 3' UTR A→G, -826CT and -881AG polymorphisms and prostate cancer risk among Chinese.
  
  
  METHODS
  The polymorphisms were genotyped via PCR-RFLP technique on 936 prostate cancer patients and 936 population-based healthy controls. Logistic regression model was used to measure the risk association present.
  
  
  RESULTS
  With the exception of NFKBIA 3' UTR polymorphism, the heterozygous and mutant genotypes of the other polymorphisms were significantly associated with prostate cancer risk. For NFKB1 polymorphism, a decreased risk was observed, with adjusted OR: 0.69; 95% CI: 0.44, 0.98; P=0.01 (heterozygous) and adjusted OR: 0.60; 95% CI: 0.37, 0.91; P=0.02 (mutant). NFKBIA -826CT and -881AG polymorphisms were in complete linkage disequilibrium and shared the same risk association, with adjusted OR: 1.34; 95% CI: 1.09, 1.62; P=0.02 (heterozygous) and adjusted OR: 2.83; 95% CI: 1.79, 4.50; P=0.01 (mutants). Interestingly, the impact of the NFKB1 polymorphism was not present in nonsmokers and younger (<60 years) subjects (P<0.05).
  
  
  CONCLUSIONS
  In conclusion, polymorphisms in NFKB1 and NFKBIA genes may modulate the risk of developing prostate cancer among Chinese.
authors.affiliation: Internal Medicine-Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland).
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Urology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland).
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland).
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.affiliation: Department of Urology, Bengbu Third People's Hospital, Bengbu, Anhui, China (mainland).
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland).
authors.forename: Juan
authors.initials: J
authors.lastname: Mei
authors.affiliation: Department of Urology, The People's Liberation Army 123rd Hospital China, Bengbu, Anhui, China (mainland).
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Urology, Bengbu First People's Hospital, Bengbu, Anhui, China (mainland).
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Internal Medicine-Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland).
authors.forename: Zi-An
authors.initials: ZA
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D000072000:NF-KappaB Inhibitor alpha; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011471:Prostatic Neoplasms / Q000235:genetics*
chemical_list: D020672:I-kappa B Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C000606204:NFKBIA protein, human; D000072000:NF-KappaB Inhibitor alpha