title: High-intensity focused ultrasound (HIFU) for adenomyosis: Two-year follow-up results.
abstract: OBJECTIVE
  To evaluate the long-term improvement of clinical symptoms of adenomyosis after treatment with ultrasound-guided high intensity focused ultrasound (USgHIFU).
  
  
  METHODS
  From January 2010 to December 2011, 350 patients with adenomyosis were treated with USgHIFU. Among the 350 patients, 224 of them completed the two years follow-up. The patients were followed up at 3 months, 1 year, and 2 years after HIFU treatment. Adverse effects and complications were recorded.
  
  
  RESULTS
  All patients completed HIFU ablation without severe postoperative complications. 203 of the 224 patients who showed varying degrees of dysmenorrhea before treatment had the symptom scores decreased significantly after treatment (P<0.001). The relief rate was 84.7%, 84.7%, and 82.3%, respectively at 3 months, 1 year, and 2 years after treatment. The menstrual volume in 109 patients with menorrhagia was significantly improved after treatment (P<0.001) with a relief rate of 79.8%, 80.7%, and 78.9%, respectively at 3 months, 1 year, and 2 years after HIFU treatment.
  
  
  CONCLUSIONS
  With its ability to sustain long-term clinical improvements, HIFU is a safe and effective treatment for adenomyosis.
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Lian
authors.initials: L
authors.lastname: Shui
authors.affiliation: Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Mao
authors.affiliation: Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099, PR China.
authors.forename: Ruitao
authors.initials: R
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China; Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121, PR China.
authors.forename: Kequan
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000, PR China. Electronic address: hejia0820@sina.com.cn.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, PR China. Electronic address: lianwzhang@yahoo.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D062788:Adenomyosis / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D004412:Dysmenorrhea / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D057086:High-Intensity Focused Ultrasound Ablation / Q000009:adverse effects; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
keywords: Adenomyosis; Adverse effect; Long-term follow-up; Ultrasound-guided high-intensity focused ultrasound