title: Zoledronic Acid for the Treatment of Children With Refractory Central Giant Cell Granuloma.
abstract: There are no approved medical therapies for the treatment of pediatric central giant cell granuloma (CGCG), a benign but potentially aggressive tumor of the jaw. Zoledronic acid (ZA), a third-generation bisphosphonate, has been used in CGCG occurring in adults. We describe 4 patients with CGCG treated with ZA, 3 of whom achieved resolution of disease up to 4 years of follow-up. Our experience suggests that ZA may be considered as treatment for pediatric CGCG.
authors.affiliation: *Keck School of Medicine, University of Southern California †Division of Hematology, Oncology, and Blood and Marrow Transplantation ‡Division of Plastic Surgery, Children's Hospital Los Angeles, Los Angeles, CA §Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
authors.forename: May C
authors.initials: MC
authors.lastname: Chien
authors.forename: Leo
authors.initials: L
authors.lastname: Mascarenhas
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hammoudeh
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004164:Diphosphonates / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D005260:Female; D006101:Granuloma, Giant Cell / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid