title: Chemokines and their receptors play important roles in the development of hepatocellular carcinoma.
abstract: The chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Their functions in the immune system have been well elucidated and research during the last decades unveils their new roles in hepatocellular carcinoma (HCC). The chemokines and their receptors in the microenvironment influence the development of HCC by several aspects including: inflammation, effects on immune cells, angiogenesis, and direct effects on HCC cells. Regarding these aspects, pre-clinical research by targeting the chemokine system has yielded promising data, and these findings bring us new clues in the chemokine-based therapies for HCC.
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Liang
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Hu
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Ma
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Gao
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.affiliation: Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Zhong
keywords: Angiogenesis; Chemokine receptors; Chemokines; Hepatocellular carcinoma; Immune cells; Inflammation; Treatments; Tumor behaviors