title: Development of optical biosensor technologies for cardiac troponin recognition.
abstract: Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events. The cardiac troponin concentration level in blood has been shown to rise rapidly for 4-10 days after onset of AMI, making it an attractive approach for a long diagnosis window for detection. The extremely low clinical sensing range of cardiac troponin levels consequently makes the methods of detection highly sensitive. In this review, by taking into consideration optical methods applied for cardiac troponin detection, we discuss the most commonly used methods of optical immunosensing and provide an overview of the various diagnostic cardiac troponin immunosensors that have been employed for determination of cardiac troponin over the last several years.
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address: abdolrahim@aut.ac.ir.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Abdolrahim
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rabiee
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Sanaz Naghavi
authors.initials: SN
authors.lastname: Alhosseini
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Tahriri
authors.affiliation: Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Yazdanpanah
authors.affiliation: Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, WI 53201, USA; Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood*; D055095:Optics and Photonics / Q000379:methods*; D014336:Troponin / Q000097:blood*
chemical_list: D014336:Troponin