title: 1,4,5-Trihydroxy-7-methoxy-9H-fluoren-9-one, a new cytotoxic compound from Dendrobium chrysotoxum.
abstract: A new compound, 1,4,5-trihydroxy-7-methoxy-9H-fluoren-9-one, has been isolated together with two known fluorenones, dendroflorin and denchrysan A, from the whole plant of Dendrobium chrysotoxum, a plant of Dendrobium genus, used as a health-food. The structure of the fluorenones has been determined on the basis of spectroscopic studies. The isolated compounds were evaluated in vitro for their inhibitory ability against the growth of human leukaemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer SGC-7901. All three fluorenones displayed selective cytotoxicity against BEL-7402 with IC50 values of 1.49, 0.97 and 1.38μg/ml, respectively.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650092, China. Electronic address: ygchen48@gmail.com.
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650092, China.
authors.forename: Yupeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Yunnan Key Laboratory of Pharmacology for Natural Products Research, Kunming Medical College, Kunming 650031, China. Electronic address: qingchenhh@yeah.net.
authors.forename: Chen
authors.initials: C
authors.lastname: Qing
authors.affiliation: Yunnan Key Laboratory of Pharmacology for Natural Products Research, Kunming Medical College, Kunming 650031, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650092, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650092, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
keywords: 1,4,5-Trihydroxy-7-methoxy-9H-fluoren-9-one; Cytotoxicity; Dendrobium chrysotoxum; Fluorenones; Orchidaceae