title: Effects of chelated Zn/Cu/Mn on redox status, immune responses and hoof health in lactating Holstein cows.
abstract: To evaluate the effects of chelated Zn/Cu/Mn on redox status, immune responses and hoof health in lactating Holstein cows, 48 head in early lactation were divided into healthy or lame groups according to their gait score. Cows were fed the same amount of Zn/Cu/Mn as sulfate salts or in chelated forms for 180 days, and foot-and-mouth disease (FMD) vaccine was injected at day 90. The results showed that lame cows had lower antioxidant function, serum Zn/Mn levels, hair Cu levels, and hoof hardness. Moreover, increased antioxidant status, FMD antibody titers, serum and hair levels of Zn/Cu/Mn, and hoof hardness and decreased milk fat percent and arthritis biomarkers were observed in cows fed chelated Zn/Cu/Mn. In summary, supplementation with chelated Zn/Cu/Mn improved antioxidant status and immune responses, reduced arthritis biomarkers, and increased accumulation of Zn/Cu/Mn in the body and hoof hardness in dairy cows.
authors.affiliation: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhao
authors.affiliation: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
authors.forename: Zhong-Peng
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Institute of Dairy Science, Zhejiang University, Hangzhou 310029, China.
authors.forename: Jun-Hong
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Qingdao BoYu Farm Co., Ltd., Qingdao 266600, China.
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Xing
authors.affiliation: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
authors.forename: Zhen-Yong
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Wang
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D015913:Chelation Therapy / Q000662:veterinary*; D003300:Copper / Q000627:therapeutic use*; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D006724:Hoof and Claw; D007113:Immunity, Innate; D007794:Lameness, Animal / Q000188:drug therapy* / Q000209:etiology; D008345:Manganese / Q000627:therapeutic use*; D008715:Methionine / Q000031:analogs & derivatives / Q000627:therapeutic use; D010084:Oxidation-Reduction; D013431:Sulfates / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D013431:Sulfates; D008345:Manganese; C008391:alpha-hydroxy-gamma-methylmercaptobutyric acid; D003300:Copper; D008715:Methionine; D015032:Zinc
keywords: chelated trace mineral; healthy cow; hoof; lame cow; redox status