title: In Vitro and In Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus.
abstract: Oscillations in hippocampal local field potentials (LFP) reflect the coordinated, rhythmic activity of constituent interneuronal and principal cell populations. Quantifying changes in oscillatory patterns and power therefore provides a powerful metric through which to infer mechanisms and functions of hippocampal network activity at the mesoscopic level, bridging single-neuron studies to behavioral assays of hippocampal function. Here, complementary protocols that enable mechanistic analyses of oscillation generation in vitro (in slices and a whole hippocampal preparation) and functional analyses of hippocampal circuits in behaving mice are described. Used together, these protocols provide a comprehensive view of hippocampal phenotypes in mouse models, highlighting oscillatory biomarkers of hippocampal function and dysfunction. Curr. Protoc. Mouse Biol. 2:273-294 © 2012 by John Wiley & Sons, Inc.
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: L H
authors.initials: LH
authors.lastname: Forsyth
authors.affiliation: Pfizer Applied Neurophysiology Group, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Witton
authors.affiliation: Pfizer Applied Neurophysiology Group, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: J T
authors.initials: JT
authors.lastname: Brown
authors.affiliation: Pfizer Applied Neurophysiology Group, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: A D
authors.initials: AD
authors.lastname: Randall
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: M W
authors.initials: MW
authors.lastname: Jones
keywords: LFP; electrophysiology; gamma rhythm; in vitro; in vivo; slice; theta rhythm