title: CorMatrix Extracellular Matrix Used for Valve Repair in the Adult: Is There De Novo Valvular Tissue Seen?
abstract: Decellularized extracellular matrix from porcine intestinal submucosa is available as an approved material for the repair of tissues including cardiac structures. Although pathologic findings of explanted CorMatrix (CorMatrix Cardiovascular, Inc, Roswell, GA) used for valvular repair have been reported in the pediatric population, there is a paucity of data in the adult population. Herein, we report the histologic changes in explanted CorMatrix from 2 adults at 10 and 18 months post-implant.
authors.affiliation: Division of Cardiology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada.
authors.forename: Adriana
authors.initials: A
authors.lastname: Luk
authors.affiliation: Division of Cardiovascular Surgery, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada.
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.affiliation: Division of Cardiovascular Surgery, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Cusimano
authors.affiliation: Division of Cardiovascular Surgery, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada.
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
authors.affiliation: Department of Pathology, Toronto General Hospital/University Health Network, Toronto, Ontario, Canada. Electronic address: jagdish.butany@uhn.ca.
authors.forename: Jagdish
authors.initials: J
authors.lastname: Butany
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001705:Bioprosthesis; D005109:Extracellular Matrix / Q000637:transplantation*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011474:Prosthesis Design; D013552:Swine