title: [Biomarkers of vascular calcifications: the osteoprotegerin/RANK/RANK L axis].
abstract: A better knowledge of physiopathologic phenomena responsible for vascular mineralization leads to emerging biological markers of vascular calcifications. In calcified arteries, the presence of bone matrix as well as osteoblast cells suggest that vascular calcification is an active and highly regulated process. The OPG/RANK/RANKL system is clearly of central significance in controlling vascular calcifications as in bone metabolism. Converging results suggest that circulating OPG determination should be a relevant marker of calcifications. The OPG/RANK/RANKL pathway also represents a potential therapeutic target in diseases associated with high bone resorption.
authors.affiliation: Service de biochimie, CHU de Montpellier, Université de Montpellier 1, Montpellier, France, U 1046 Inserm, Université de Montpellier 1, Montpellier, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bargnoux
authors.affiliation: Service de biochimie, CHU de Montpellier, Université de Montpellier 1, Montpellier, France, U 1046 Inserm, Université de Montpellier 1, Montpellier, France, Institut de recherche et de formation en dialyse, Montpellier, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
authors.affiliation: Unité de biochimie hormonale et nutritionnelle, Institut de biologie et pathologie, CHU Grenoble, Grenoble, France ; Inserm U1055, Grenoble, France.
authors.forename: Josiane
authors.initials: J
authors.lastname: Arnaud
authors.affiliation: Service de chimie médicale, CHU Sart Tilman, Université de Liège, Liège, Belgique.
authors.forename: Étienne
authors.initials: É
authors.lastname: Cavalier
authors.affiliation: Clinique universitaire de néphrologie, CHU Grenoble, Grenoble, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Zaoui
authors.affiliation: Service de néphrologie-dialyse-transplantation rénale, CHU Sart Tilman, Université de Liège, Liège, Belgique.
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.affiliation: Service de biochimie, CHU de Montpellier, Université de Montpellier 1, Montpellier, France, U 1046 Inserm, Université de Montpellier 1, Montpellier, France, Institut de recherche et de formation en dialyse, Montpellier, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.affiliation: Service de biochimie, CHU de Montpellier, Université de Montpellier 1, Montpellier, France, U 1046 Inserm, Université de Montpellier 1, Montpellier, France, Institut de recherche et de formation en dialyse, Montpellier, France, Unité de biochimie hormonale et nutritionnelle, Institut de biologie et pathologie, CHU Grenoble, Grenoble, France ; Inserm U1055, Grenoble, France, Service de chimie médicale, CHU Sart Tilman, Université de Liège, Liège, Belgique, Clinique universitaire de néphrologie, CHU Grenoble, Grenoble, France, Service de néphrologie-dialyse-transplantation rénale, CHU Sart Tilman, Université de Liège, Liège, Belgique.
mesh_terms: D015415:Biomarkers; D001842:Bone and Bones / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D053244:Osteoprotegerin / Q000502:physiology*; D053245:RANK Ligand / Q000502:physiology*; D061205:Vascular Calcification / Q000209:etiology*
chemical_list: D015415:Biomarkers; D053244:Osteoprotegerin; D053245:RANK Ligand; C506030:TNFRSF11B protein, human
keywords: bone; osteoprotegerin; receptor activator of NFkB ligand (RANKL); vascular calcification