title: A new Bayesian model applied to cytogenetic partial body irradiation estimation.
abstract: A new zero-inflated Poisson model is introduced for the estimation of partial body irradiation dose and fraction of body irradiated. The Bayes factors are introduced as tools to help determine whether a data set of chromosomal aberrations obtained from a blood sample reflects partial or whole body irradiation. Two examples of simulated cytogenetic radiation exposure data are presented to demonstrate the usefulness of this methodology in cytogenetic biological dosimetry.
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK Departament de Matemàtiques, Universitat Autònoma de Barcelona, Barcelona, Spain manuel.higueras-hernaez@phe.gov.uk.
authors.forename: Manuel
authors.initials: M
authors.lastname: Higueras
authors.affiliation: Departament de Matemàtiques, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Puig
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Ainsbury
authors.affiliation: Grigoriev Institute for Medical Radiology of the National Academy of Medical Science of Ukraine, Kharkiv, Ukraine.
authors.forename: Volodymyr A
authors.initials: VA
authors.lastname: Vinnikov
authors.affiliation: Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Rothkamm
mesh_terms: D001499:Bayes Theorem; D016026:Bone Marrow Transplantation; D002470:Cell Survival / Q000235:genetics* / Q000528:radiation effects; D020732:Cytogenetic Analysis / Q000379:methods*; D006801:Humans; D058958:Organs at Risk / Q000528:radiation effects*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D014916:Whole-Body Irradiation