title: [New metabolic index in the diagnosis of insulin resistance in patients with nonalcoholic fatty liver disease].
abstract: Early diagnosis of insulin resistance (IR) in patients with non-alcoholic fatty liver disease (NAFLD) is relevant in connection with the possibility of timely correction and the primary prevention of cardiovascular disease.
  
  
  OBJECTIVE
  To evaluate the diagnostic significance of the new metabolic index (MI) in the early diagnosis of IR in patients with NAFLD.
  
  
  METHODS
  In 494 patients with ultrasonographic evidence of NAFLD have been studied lipid and carbohydrate metabolism. Indirect methods of assessment of IR were analyzed and we proposed a new MI.
  
  
  CONCLUSIONS
  NAFLD is accompanied by a progression of metabolic disorders and atherogenic dyslipidemia, disorders of carbohydrate metabolism, changes in the functional state of the liver. In the early stages of IR for the initial isolate changes of carbohydrates and lipid metabolism MI index is more sensitive to the existing violations, and with the progression of changes in laboratory parameters observed its gradual increase.
  
  
  CONCLUSIONS
  MI can be recommended in clinical practice for screening IR in NAFLD patients for further in-depth examination.
authors.forename: G E
authors.initials: GE
authors.lastname: Roĭtberg
authors.forename: O O
authors.initials: OO
authors.lastname: Sharkhun
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Dorosh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D050260:Carbohydrate Metabolism; D003627:Data Interpretation, Statistical; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014280:Triglycerides