title: Prospective Randomized Study of Sarpogrelate Versus Clopidogrel-based Dual Antiplatelet Therapies in Patients Undergoing Femoropopliteal Arterial Endovascular Interventions: Preliminary Results.
abstract: BACKGROUND
  Sarpogrelate is a selective 5-hydroxytryptamine (5-HT) receptor subtype 2A antagonist which blocks 5-HT induced platelet aggregation and proliferation of vascular smooth muscle cells. We compared the efficacy of sarpogrelate-based dual antiplatelet therapies for the prevention of restenosis and target lesion revascularization (TLR) rates comparing with that of clopidogrel after percutaneous endovascular interventions (EVIs) of femoropopliteal (FP) arterial lesions.
  
  
  METHODS
  This prospective, multicenter, randomized clinical trial recruited a total of 120 patients with successful EVI of FP lesions at seven centers across China between January 2011 and June 2012. Patients were randomized to receive either sarpogrelate (100 mg trice daily for 6 months, n = 63) or clopidogrel (75 mg once daily for 6 months, n = 57). All patients also received oral aspirin (100 mg once daily for 12 months). Clinical follow-up was conducted up to 12 months postprocedure.
  
  
  RESULTS
  There was no significant difference between the two groups in basic demographic data. The restenosis rate was higher in the clopidogrel group (22.80%) than in sarpogrelate group (17.50%), but there was no significant difference between these two groups (P = 0.465). The TLR rate, ipsilateral amputation rate, mortality in all-cause and bleeding rate were also similar in the two groups (P > 0.05).
  
  
  CONCLUSIONS
  Aspirin plus sarpogrelate is a comparable antithrombotic regimen to aspirin plus clopidogrel after EVI of FP arterial lesions. Dual antiplatelet therapies might play an important role in preventing restenosis after successful EVI of FP lesions.
authors.forename: Yue-Xin
authors.initials: YX
authors.lastname: Chen
authors.forename: Wen-Da
authors.initials: WD
authors.lastname: Wang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Song
authors.forename: Yong-Quan
authors.initials: YQ
authors.lastname: Gu
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Tian
authors.forename: He-Jie
authors.initials: HJ
authors.lastname: Hu
authors.forename: Ji-Chun
authors.initials: JC
authors.lastname: Zhao
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Li
authors.affiliation: Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100068, China.
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Liu
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D000077144:Clopidogrel; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000188:drug therapy; D011150:Popliteal Artery / Q000187:drug effects / Q000473:pathology; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013386:Succinates / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D012702:Serotonin Antagonists; D013386:Succinates; C064294:sarpogrelate; D000077144:Clopidogrel; D013988:Ticlopidine