title: Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people.
abstract: Ability to taste Phenylthiocarbamide (PTC) a bitter molecule, is usually used to know the heritable characteristic in both genetic and physiological studies. So far, no research has yet attested whether PTC blindness relation with obesity and some nutrition behaviors of human. This study is the first attempt on a large scale to examine PTC sensitivity in healthy and overweight people in Turkish population to define in the perception of bitter senses which is associated with nutrition habits, body mass index, age, gender, and to be in stable weight. PTC taste perception was measured by tasting PTC solution filtered in a paper. The results showed that tasters were significantly more frequent (81,8%) than nontasters (18,2%) in all population. A higher proportion of nontasters were observed in the quite fat individual group (BMI >40kg/m(2)). Alterations explained these differences in basic taste sensitivity, age, gender, BMI, individuals' family obesity situations, vegetarian nourishment. Increased frequency of nontasters allele is evident with obesity condition. This could be due to lack of preference for nutrition among nontasters. So the phenotypic variation in PTC sensitivity is genetic in origin; it may represent an association with obesity, dietary habits, regular weight, gender, and age.
authors.affiliation: Department of Zootechnical and Animal Nutrition, Faculty of Veterinary, Cumhuriyet University, Sivas, Turkey.
authors.forename: SevgiDurna
authors.initials: S
authors.lastname: Dastan
authors.affiliation: Department of Molecular Biology and Genetics, Faculty of Science, Cumhuriyet University, Sivas, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Degerli
authors.affiliation: Department of Chemistry, Faculty of Arts and Science, Bingol University, Bingol, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Dastan
authors.affiliation: Tuzla Campus Vocational School of Health Services, Okan University, Akfirat, Tuzla, Istanbul, Turkey.
authors.forename: Fazilet
authors.initials: F
authors.lastname: Yildiz
authors.affiliation: Department of Biology, Faculty of Science, Cumhuriyet University, Sivas, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yildir
authors.affiliation: Department of Biology, Faculty of Science, Cumhuriyet University, Sivas, Turkey.
authors.forename: Yusuf Muhammed
authors.initials: YM
authors.lastname: Durna
authors.affiliation: Department of Biology, Faculty of Arts and Science, Firat University, Elazig, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Atessahin
authors.affiliation: Department of Biology, Faculty o-f Arts and Science, Gazi Osman Pasa University, Tokat, Turkey.
authors.forename: Tunay
authors.initials: T
authors.lastname: Karan
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D005247:Feeding Behavior; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000235:genetics; D009765:Obesity / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D010641:Phenotype; D010670:Phenylthiourea / Q000008:administration & dosage*; D012307:Risk Factors; D012737:Sex Factors; D055697:Taste Perception / Q000235:genetics*; D014421:Turkey; D015430:Weight Gain / Q000235:genetics; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D010670:Phenylthiourea