title: Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin.
abstract: RESULTS
  Oleuropein promoted cultured human follicle dermal papilla cell proliferation and induced LEF1 and Cyc-D1 mRNA expression and β-catenin protein expression in dermal papilla cells. Nuclear accumulation of β-catenin in dermal papilla cells was observed after oleuropein treatment. Topical application of oleuropein (0.4 mg/mouse/day) to C57BL/6N mice accelerated the hair-growth induction and increased the size of hair follicles in telogenic mouse skin. The oleuropein-treated mouse skin showed substantial upregulation of Wnt10b, FZDR1, LRP5, LEF1, Cyc-D1, IGF-1, KGF, HGF, and VEGF mRNA expression and β-catenin protein expression.
  
  
  CONCLUSIONS
  These results demonstrate that topical oleuroepin administration induced anagenic hair growth in telogenic C57BL/6N mouse skin. The hair-growth promoting effect of oleuropein in mice appeared to be associated with the stimulation of the Wnt10b/β-catenin signaling pathway and the upregulation of IGF-1, KGF, HGF, and VEGF gene expression in mouse skin tissue.
authors.affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, Seoul, South Korea.
authors.forename: Tao
authors.initials: T
authors.lastname: Tong
authors.affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, Seoul, South Korea.
authors.forename: Nahyun
authors.initials: N
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Brain Korea 21 PLUS Project, Yonsei University, Seoul, South Korea.
authors.forename: Taesun
authors.initials: T
authors.lastname: Park
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation; D018859:Hair Follicle / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D057888:Iridoid Glucosides; D039823:Iridoids / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015854:Up-Regulation; D060449:Wnt Signaling Pathway
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D057888:Iridoid Glucosides; D039823:Iridoids; C002769:oleuropein