title: Distribution and drug resistance profile of methicillin-resistant Staphylococcus aureus after orthopaedic surgery.
abstract: This paper is aimed to comprehend clinical distribution and drug-resistance situation of methicillin-resistant Staphylococcus aureus. This study applied automatic microbe instrument Microscan W/A 96 for strain identification and drug susceptibility screening on the isolated strains. It was found that 312 MRSA strains were isolated in three years, which account for 58.1% of Staphylococcus aureus. MRSA were mainly focused in wound secretion, purulent sputum and prostatic fluid and a few of them were isolated from blood specimens; Endemic area distribution was mainly located in intensive care unit, neurosurgery, respiratory department, dermatology, orthopaedic burns and orthopaedics. MRSA strains showed high drug resistance of 82.37%~100% to most of the antibiotics including vancomycin, cotrimoxazole and rifampicin. Strain was 100% resistance towards ampicillin, amoxicillin/acid, cefalotin, cefazolin, tienam, benzylpenicillin, penicillin and tetracycline and 90% strains resisted clindamycin, cefotaxime, clarithromycin and gentamicin.
authors.affiliation: Department of Orthopedic Trauma, People's Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: Wen Chao
authors.initials: WC
authors.lastname: Song
authors.affiliation: Department of Orthopedic Trauma, People's Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: Si Sen
authors.initials: SS
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Trauma, People's Hospital of Zhengzhou, Zhengzhou City, Henan Province, China.
authors.forename: Yu Hong
authors.initials: YH
authors.lastname: Gong
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003428:Cross Infection / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D019637:Orthopedic Procedures / Q000009:adverse effects*; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents