title: Disrupted resting-state attentional networks in T2DM patients.
abstract: Although Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for dementia, the neural mechanisms that underlie cognitive impairment in T2DM remain unclear. This study uses resting-state functional magnetic resonance imaging (fMRI) to examine attention network alterations in T2DM and their relationships to impaired cognitive performance. Data-driven independent component analysis was applied to resting-state fMRI data from 38 T2DM patients and 32 healthy controls to identify the dorsal attention network (DAN) and ventral attention network (VAN). Correlations were then determined among the resting-state functional connectivity (rsFC), clinical data, and neuropsychological scores. The T2DM patients exhibited decreased rsFC in the left middle frontal gyrus (MFG) and bilateral inferior parietal lobe (IPL) of the DAN, as well as the left IPL and right MFG/IFG of the VAN. In addition, the rsFC of the left MFG was inversely correlated with the Trail Making Test-B scores; the rsFC of the left IPL was positively correlated with the Digit Span Test scores but negatively correlated with HbA1c; and the rsFC in the right precuneus was positively associated with cognitive performance (without Bonferroni correction). In conclusion, T2DM affects resting-state attentional networks, which may be related to reduced attention and a hyperglycemic state.
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.|Medical school of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.|Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, USA, 19104.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wang
authors.affiliation: Center for functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, USA, 19104.
authors.forename: Hengyi
authors.initials: H
authors.lastname: Rao
authors.affiliation: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA, 19104.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Spaeth
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Pin
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Cai
authors.affiliation: Department of Endocrinology, affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing, China, 210009.
authors.forename: Haixia
authors.initials: H
authors.lastname: Sun
mesh_terms: D000368:Aged; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D003071:Cognition / Q000502:physiology; D003704:Dementia / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human