title: Antifungal activity of extracts and isolated compounds from Buchenavia tomentosa on Candida albicans and non-albicans.
abstract: OBJECTIVE
  This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species.
  
  
  METHODS
  The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated.
  
  
  RESULTS
  Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata.
  
  
  CONCLUSIONS
  Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata.
authors.affiliation: Oral Biopathology Graduate Program, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.
authors.forename: Guilherme R
authors.initials: GR
authors.lastname: Teodoro
authors.affiliation: Department of Orthodontics & Pediatric Dentistry, Araraquara Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.
authors.forename: Fernanda L
authors.initials: FL
authors.lastname: Brighenti
authors.affiliation: Department of Pediatric Dentistry, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.
authors.forename: Alberto C Botazzo
authors.initials: AC
authors.lastname: Delbem
authors.affiliation: Department of Pediatric Dentistry, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil.
authors.forename: Ádina Cléia B
authors.initials: ÁC
authors.lastname: Delbem
authors.affiliation: Faculdade de Ciências da Saúde, Universidade do Vale do Paraíba (UNIVAP), São José dos Campos, São Paulo, Brazil.
authors.forename: Sonia
authors.initials: S
authors.lastname: Khouri
authors.affiliation: Department of Environmental Engineering, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.|Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Aline Vidal L
authors.initials: AV
authors.lastname: Gontijo
authors.affiliation: Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Aislan Crf
authors.initials: AC
authors.lastname: Pascoal
authors.affiliation: Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Salvador
authors.affiliation: Oral Biopathology Graduate Program, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.|Department of Environmental Engineering, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil.
authors.forename: Cristiane Y
authors.initials: CY
authors.lastname: Koga-Ito
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D002175:Candida / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D029764:Combretaceae / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D013057:Spectrum Analysis
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts
keywords: Candida albicans; Candida non-albicans; antifungal agents; natural compounds