title: Genetic variability and distribution of Classical swine fever virus.
abstract: Classical swine fever is a highly contagious disease that affects domestic and wild pigs worldwide. The causative agent of the disease is Classical swine fever virus (CSFV), which belongs to the genus Pestivirus within the family Flaviviridae. On the genome level, CSFV can be divided into three genotypes with three to four sub-genotypes. Those genotypes can be assigned to distinct geographical regions. Knowledge about CSFV diversity and distribution is important for the understanding of disease dynamics and evolution, and can thus help to design optimized control strategies. For this reason, the geographical pattern of CSFV diversity and distribution are outlined in the presented review. Moreover, current knowledge with regard to genetic virulence markers or determinants and the role of the quasispecies composition is discussed.
authors.affiliation: Institute of Diagnostic Virology,Friedrich-Loeffler-Institut,Suedufer 10,17493 Greifswald-Insel Riems,Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Beer
authors.affiliation: Institute of Diagnostic Virology,Friedrich-Loeffler-Institut,Suedufer 10,17493 Greifswald-Insel Riems,Germany.
authors.forename: Katja V
authors.initials: KV
authors.lastname: Goller
authors.affiliation: Institute of Epidemiology,Friedrich-Loeffler-Institut,Suedufer 10,17493 Greifswald-Insel Riems,Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Staubach
authors.affiliation: Institute of Diagnostic Virology,Friedrich-Loeffler-Institut,Suedufer 10,17493 Greifswald-Insel Riems,Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Blome
mesh_terms: D000818:Animals; D006691:Classical Swine Fever / Q000821:virology*; D006692:Classical Swine Fever Virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D014644:Genetic Variation; D008969:Molecular Sequence Data; D013552:Swine; D014759:Viral Envelope Proteins / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D014759:Viral Envelope Proteins
keywords: Classical swine fever virus; genetic diversity; genotype distribution; quasispecies; virulence factors