title: Intelligent system design for bionanorobots in drug delivery.
abstract: A nanorobot is defined as any smart structure which is capable of actuation, sensing, manipulation, intelligence, and swarm behavior at the nanoscale. In this study, we designed an intelligent system using fuzzy logic for diagnosis and treatment of tumors inside the human body using bionanorobots. We utilize fuzzy logic and a combination of thermal, magnetic, optical, and chemical nanosensors to interpret the uncertainty associated with the sensory information. Two different fuzzy logic structures, for diagnosis (Mamdani structure) and for cure (Takagi-Sugeno structure), were developed to efficiently identify the tumors and treat them through delivery of effective dosages of a drug. Validation of the designed system with simulated conditions proved that the drug delivery of bionanorobots was robust to reasonable noise that may occur in the bionanorobot sensors during navigation, diagnosis, and curing of the cancer cells. Bionanorobots represent a great hope for successful cancer therapy in the near future.
authors.affiliation: Biomedical Engineering, University of Guelph, Guelph, Ontario Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Fletcher
authors.affiliation: Mechanical Engineering, University of Guelph, Guelph, Ontario Canada.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Biglarbegian
authors.affiliation: Biomedical Engineering, University of Guelph, Guelph, Ontario Canada ; BioNano Laboratory, School of Engineering, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 Canada.
authors.forename: Suresh
authors.initials: S
authors.lastname: Neethirajan
keywords: Bionanorobot; Control system; Drug delivery; Fuzzy logic; Nanomedicine