title: Effects of Malva sylvestris and Its Isolated Polysaccharide on Experimental Ulcerative Colitis in Rats.
abstract: Malva sylvestris is an edible plant that is consumed as a herbal supplement for its antiulcer and colon cleansing properties in traditional Persian medicine. This study was designed to evaluate its effects on ulcerative colitis, which is a chronic gastrointestinal inflammation. Colitis was induced by rectal instillation of acetic acid solution. Rats in different groups received aqueous, n-hexane, or ethanolic fractions of the plant before induction of colitis. Isolated polysaccharide of plant was also tested in 2 groups before and after induction of colitis. Macroscopic and microscopic evaluation of colitis showed that the aqueous fraction was very effective in preventing the inflammation and efficacy was lower for ethanolic and n-hexane fractions. Polysaccharide was effective in reducing signs of inflammation, especially as pretreatment. These beneficial effects provide evidences that this plant can be suggested for patients with this disease to improve their health condition or to reduce adverse effects of their medication.
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Hamedi
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Rezaei
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Negar
authors.initials: N
authors.lastname: Azarpira
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Jafarpour
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran ahmadi_f@sums.ac.ir.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ahmadi
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000473:pathology*; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D028501:Malva / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides
keywords: Malva sylvestris; experimental colitis; inflammation; inflammatory bowel disease; polysaccharide