title: Association of genetic polymorphisms in HTR3A and HTR3E with diarrhea predominant irritable bowel syndrome.
abstract: OBJECTIVE
  The present study aims to investigate the relationship between genetic polymorphisms in HTR3A and HTR3E and diarrhea predominant irritable bowel syndrome (D-IBS) in a Chinese population.
  
  
  METHODS
  We enrolled 500 D-IBS patients and 500 age- and sex-matched healthy control subjects to detect the genotypes in HTR3A and HTR3B gene by using of PCR-RFLP method.
  
  
  RESULTS
  There were significant difference between the D-IBS patients and the health control subjects in the distribution of genotype and allele of rs1062613 in HTR3A gene. As regarding rs62625044 in HTR3E gene, we found there was a significant different between the case and the control group in the distribution of GA genotype and A allele in female but not in male.
  
  
  CONCLUSIONS
  The present study suggested that there are associations of D-IBS risk with genetic polymorphisms in HTR3A and HTR3E.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, Shaanxi Province, P. R. China ; Department of Gastroenterology, Affiliated Hospital of Yan'an University Yan'an 716000, Shaanxi Province, P. R. China.
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, Shaanxi Province, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Yan'an University Yan'an 716000, Shaanxi Province, P. R. China.
authors.forename: Yi-Chao
authors.initials: YC
authors.lastname: Feng
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Yan'an University Yan'an 716000, Shaanxi Province, P. R. China.
authors.forename: Guang-Rong
authors.initials: GR
authors.lastname: Dai
authors.affiliation: Department of Gastroenterology, Affiliated Hospital of Yan'an University Yan'an 716000, Shaanxi Province, P. R. China.
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Du
keywords: Diarrhea predominant irritable bowel syndrome; HTR3A; HTR3E; gene; polymorphism