title: Breast DCE-MRI Kinetic Heterogeneity Tumor Markers: Preliminary Associations With Neoadjuvant Chemotherapy Response.
abstract: The ability to predict response to neoadjuvant chemotherapy for women diagnosed with breast cancer, either before or early on in treatment, is critical to judicious patient selection and tailoring the treatment regimen. In this paper, we investigate the role of contrast agent kinetic heterogeneity features derived from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for predicting treatment response. We propose a set of kinetic statistic descriptors and present preliminary results showing the discriminatory capacity of the proposed descriptors for predicting complete and non-complete responders as assessed from pre-treatment imaging exams. The study population consisted of 15 participants: 8 complete responders and 7 non-complete responders. Using the proposed kinetic features, we trained a leave-one-out logistic regression classifier that performs with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.84 under the ROC. We compare the predictive value of our features against commonly used MRI features including kinetics of the characteristic kinetic curve (CKC), maximum peak enhancement (MPE), hotspot signal enhancement ratio (SER), and longest tumor diameter that give lower AUCs of 0.71, 0.66, 0.64, and 0.54, respectively. Our proposed kinetic statistics thus outperform the conventional kinetic descriptors as well as the classifier using a combination of all the conventional descriptors (i.e., CKC, MPE, SER, and longest diameter), which gives an AUC of 0.74. These findings suggest that heterogeneity-based DCE-MRI kinetic statistics could serve as potential imaging biomarkers for tumor characterization and could be used to improve candidate patient selection even before the start of the neoadjuvant treatment.
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Electronic address: ahmed.bilal@alumni.cmu.edu.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ashraf
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Bilwaj
authors.initials: B
authors.lastname: Gaonkar
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Mies
authors.affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Angela
authors.initials: A
authors.lastname: DeMichele
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Rosen
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: Despina
authors.initials: D
authors.lastname: Kontos