title: Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression.
abstract: Bioflavonoids are known to induce cardioprotective effects by inhibiting vascular smooth muscle cell (VSMC) proliferation and migration. Kaempferol has been shown to inhibit VSMC proliferation. However, little is known about the effect of kaempferol on VSMC migration and the underlying molecular mechanisms. Our studies provide the first evidence that kaempferol inhibits VSMC migration by modulating the BMP4 signaling pathway and microRNA expression levels. Kaempferol activates the BMP signaling pathway, induces miR-21 expression and downregulates DOCK4, 5, and 7, leading to inhibition of cell migration. Moreover, kaempferol antagonizes the PDGF-mediated pro-migratory effect. Therefore, our study uncovers a novel regulatory mechanism of VSMC migration by kaempferol and suggests that miRNA modulation by kaempferol is a potential therapy for cardiovascular diseases.
authors.affiliation: Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 406-772, Republic of Korea.
authors.forename: Kwangho
authors.initials: K
authors.lastname: Kim
authors.forename: Sunghwan
authors.initials: S
authors.lastname: Kim
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Moh
authors.forename: Hara
authors.initials: H
authors.lastname: Kang
mesh_terms: D055415:Bone Morphogenetic Protein 4 / Q000502:physiology*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D044949:Kaempferols / Q000494:pharmacology*; D035683:MicroRNAs / Q000235:genetics*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: C525809:BMP4 protein, human; D055415:Bone Morphogenetic Protein 4; D044949:Kaempferols; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; C006552:kaempferol