title: [Morphological characteristic dysplastic features on colonic adenomas].
abstract: Morphological changes of tubular adenomas with severe dysplasia are charachterized by low level of cytodifferentiation, epithelial cells intensive proliferation, detected by 3Н-Thymidine and markedly reduction of goblet cells. Functional activity of tumor parenchyma decreases with change in ATP-ase activity. The quantity of young form fibroblasts is markedly increased in adenomous stroma, which caused a disturbance of fibrillogenesis. The local immunologic response was suppressed, the activity of T-suppressors was increased. The morphology of endotheliocytes and vascular network was changed. It is concluded that, adenomas with severe dysplasia are the risk factors for the carcinoma "in situ" development; microadenomas and adenomas are the essence of a single pathological process based on dysplastic changes. It is suggested that colonic microadenomas, are the causes the rudiments of forthcoming adenoma, and in some cases may lead to malignization.
authors.affiliation: I. Javakhishvili State University, A. N. Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Gvamichava
authors.affiliation: I. Javakhishvili State University, A. N. Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Machavariani
authors.affiliation: I. Javakhishvili State University, A. N. Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Gachechiladze
authors.affiliation: I. Javakhishvili State University, A. N. Natishvili Institute of Morphology, Tbilisi, Georgia.
authors.forename: L
authors.initials: L
authors.lastname: Gogiashvili
mesh_terms: D000236:Adenoma / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D012307:Risk Factors