title: Association between colchicine resistance and vitamin D in familial Mediterranean fever.
abstract: Although colchicines are the only effective treatment of familial Mediterranean fever (FMF), resistance to colchicines (CR) which is observed in up to 30% of the patients is still a problem. Clinically, resistance to colchicine is defined as three or more attacks within the last 6 months period while using ≥2 mg/day colchicine. Previous studies have shown decreased vitamin D levels in FMF patients compared with healthy controls. The aim of this study is to evaluate whether vitamin D levels differ between CR and non-CR FMF patients. This study included 64 FMF patients who were being followed in Nephrology Clinic of Samsun Research and Education Hospital for at least 1 year. FMF was diagnosed according to the criteria defined by Livneh et al. Serum 25-hydroxy vitamin D (25-OHD) concentration (ng/mL) was detected in all FMF patients who were not in an acute attack period. From 64 patients 29 were accepted as CR. Mean 25-OHD level was 9.39 ± 1.00 ng/mL in CR patients and 18.48 ± 1.09 ng/mL in colchicine responsive patients (p < 0.001). Plasma vitamin D levels were significantly lower in colchicine resistant patients. Vitamin D deficiency may be a factor in etiopathogenesis of CR. Studies in larger patient samples that particularly evaluate the response to vitamin D replacement in CR FMF patients are needed.
authors.affiliation: a Department of Nephrology , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Ismail
authors.initials: I
authors.lastname: Ozer
authors.affiliation: b Department of Endocrinology and Metabolism , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Turkan
authors.initials: T
authors.lastname: Mete
authors.affiliation: c Department of Medical Genetics , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Ozlem
authors.initials: O
authors.lastname: Turkeli Sezer
authors.affiliation: d Department of Medical Genetics , Sevket Yilmaz Training and Research Hospital , Bursa , Turkey .
authors.forename: Guyem
authors.initials: G
authors.lastname: Kolbasi Ozgen
authors.affiliation: e Department of General Surgery , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Gultekin Ozan
authors.initials: GO
authors.lastname: Kucuk
authors.affiliation: f Department of Nephrology , School of Medicine, Ondokuz Mayis University , Samsun , Turkey , and.
authors.forename: Coskun
authors.initials: C
authors.lastname: Kaya
authors.affiliation: b Department of Endocrinology and Metabolism , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Elif
authors.initials: E
authors.lastname: Kilic Kan
authors.affiliation: b Department of Endocrinology and Metabolism , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey .
authors.forename: Gulhan
authors.initials: G
authors.lastname: Duman
authors.affiliation: g Department of Internal Medicine , Samsun Training and Research Hospital, Ministry of Health , Samsun , Turkey.
authors.forename: Hacer Pinar
authors.initials: HP
authors.lastname: Ozturk Kurt
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003078:Colchicine / Q000008:administration & dosage*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D000071198:Pyrin; D016896:Treatment Outcome; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D000071198:Pyrin; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D003078:Colchicine
keywords: Colchicines; familial Mediterranean fever; resistance to colchicines; vitamin D