title: Rehabilitation in patients with radically treated respiratory cancer: A randomised controlled trial comparing two training modalities.
abstract: BACKGROUND
  The evidence on the effectiveness of rehabilitation in lung cancer patients is limited. Whole body vibration (WBV) has been proposed as an alternative to conventional resistance training (CRT).
  
  
  METHODS
  We investigated the effect of radical treatment (RT) and of two rehabilitation programmes in lung cancer patients. The primary endpoint was a change in 6-min walking distance (6MWD) after rehabilitation. Patients were randomised after RT to either CRT, WBVT or standard follow-up (CON). Patients were evaluated before, after RT and after 12 weeks of intervention.
  
  
  RESULTS
  Of 121 included patients, 70 were randomised to either CON (24), CRT (24) or WBVT (22). After RT, 6MWD decreased with a mean of 38m (95% CI 22-54) and increased with a mean of 95m (95% CI 58-132) in CRT (p<0.0001), 37m (95% CI -1-76) in WBVT (p=0.06) and 1m (95% CI -34-36) in CON (p=0.95), respectively. Surgical treatment, magnitude of decrease in 6MWD by RT and allocation to either CRT or WBVT were prognostic for reaching the minimally clinically important difference of 54m increase in 6MWD after intervention.
  
  
  CONCLUSIONS
  RT of lung cancer significantly impairs patients' exercise capacity. CRT significantly improves and restores functional exercise capacity, whereas WBVT does not fully substitute for CRT.
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium. Electronic address: Bihiyga.Salhi@UGent.be.
authors.forename: Bihiyga
authors.initials: B
authors.lastname: Salhi
authors.affiliation: Department of Respiratory Medicine, AZ Sint Jan, Bruges, Belgium.
authors.forename: Christel
authors.initials: C
authors.lastname: Haenebalcke
authors.affiliation: Department of Respiratory Medicine, CHU St Pierre, Brussels, Belgium.
authors.forename: Silvia
authors.initials: S
authors.lastname: Perez-Bogerd
authors.affiliation: Department of Respiratory Medicine, CHU Sart Tilman, Liège, Belgium.
authors.forename: Mai D
authors.initials: MD
authors.lastname: Nguyen
authors.affiliation: Department of Respiratory Medicine, CHU St Pierre, Brussels, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ninane
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium.
authors.forename: Thomas L A
authors.initials: TL
authors.lastname: Malfait
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium.
authors.forename: Karim Y
authors.initials: KY
authors.lastname: Vermaelen
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium.
authors.forename: Veerle F
authors.initials: VF
authors.lastname: Surmont
authors.affiliation: Biostatistical Unit, Faculty of Medicine, Ghent University, Belgium.
authors.forename: Georges
authors.initials: G
authors.lastname: Van Maele
authors.affiliation: Biostatistical Unit, Faculty of Medicine, Ghent University, Belgium.
authors.forename: Roos
authors.initials: R
authors.lastname: Colman
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium.
authors.forename: Eric
authors.initials: E
authors.lastname: Derom
authors.affiliation: Department of Respiratory Medicine, Ghent University Hospital, Belgium; Thoracic Oncology, Antwerp University Hospital, Belgium.
authors.forename: Jan P
authors.initials: JP
authors.lastname: van Meerbeeck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000534:rehabilitation* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life; D055070:Resistance Training; D012129:Respiratory Function Tests; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Exercise; Lung cancer; Pulmonary rehabilitation; Radical treatment; Resistance training; Whole body vibration