title: Treatment and Prevention of (Early) Osteoarthritis Using Articular Cartilage Repair-Fact or Fiction? A Systematic Review.
abstract: Early osteoarthritis (OA) is increasingly being recognized in patients who wish to remain active while not accepting the limitations of conservative treatment or joint replacement. The aim of this systematic review was to evaluate the existing evidence for treatment of patients with early OA using articular cartilage repair techniques. A systematic search was performed in EMBASE, MEDLINE, and the Cochrane collaboration. Articles were screened for relevance and appraised for quality. Nine articles of generally low methodological quality (mean Coleman score 58) including a total of 502 patients (mean age range = 36-57 years) could be included. In the reports, both radiological and clinical criteria for early OA were applied. Of all patients included in this review, 75% were treated with autologous chondrocyte implantation. Good short-term clinical outcome up to 9 years was shown. Failure rates varied from 8% to 27.3%. The conversion to total knee arthroplasty rate was 2.5% to 6.5%. Although a (randomized controlled) trial in this patient category with long-term follow-up is needed, the literature suggests autologous chondrocyte implantation could provide good short- to mid-term clinical outcome and delay the need for total knee arthroplasty. The use of standardized criteria for early OA and implementation of (randomized) trials with long-term follow-up may allow for further expansion of the research field in articular cartilage repair to the challenging population with (early) OA.
authors.affiliation: Department of Orthopaedics University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Tommy S
authors.initials: TS
authors.lastname: de Windt
authors.affiliation: Department of Orthopaedics University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Lucienne A
authors.initials: LA
authors.lastname: Vonk
authors.affiliation: Cartilage Research Unit, University of Gothenburg, Region Halland Orthopaedics, Hallands Hospital Kungsbacka, Kungsbacka, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Brittberg
authors.affiliation: Department of Orthopaedics University Medical Center Utrecht, Utrecht, Netherlands ; MIRA Institute for Biotechnology and Technical Medicine, University of Twente, Enschede, Netherlands.
authors.forename: Daniel B F
authors.initials: DB
authors.lastname: Saris
keywords: active patients; autologous chondrocyte implantation; cartilage repair; early osteoarthritis