title: Characterization of Diterpenes from Euphorbia prolifera and Their Antifungal Activities against Phytopathogenic Fungi.
abstract: Euphorbia prolifera is a poisonous plant belonging to the Euphorbiaceae family. In this survey on plant secondary metabolites to obtain bioactive substances for the development of new antifungal agents for agriculture, the chemical constituents of the plant E. prolifera were investigated. This procedure led to the isolation of six new and two known diterpenes. Their structures, including absolute configurations, were elucidated on the basis of extensive NMR spectroscopic data analyses and time-dependent density functional theory ECD calculations. Biological screenings revealed that these diterpenes possessed antifungal activities against three phytopathogenic fungi. The results of the phytochemical investigation further revealed the chemical components of the poisonous plant E. prolifera, and biological screenings implied the extract or bioactive diterpenes from this plant may be regarded as candidate agents of antifungal agrochemicals for crop protection products.
authors.affiliation: †State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, People's Republic of China.|‡Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: §College of Pharmacy, Harbin University of Commerce, Harbin 150076, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Kang
authors.affiliation: †State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, People's Republic of China.|‡Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Cao
authors.affiliation: †State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, People's Republic of China.|‡Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Xiaocong
authors.initials: X
authors.lastname: Sun
authors.affiliation: ⊥Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Shujing
authors.initials: S
authors.lastname: Yu
authors.affiliation: ⊥Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: #Computational Centre for Molecular Science, College of Chemistry, Nankai University, Tianjin 300071, People's Republic of China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Sun
authors.affiliation: †State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, People's Republic of China.|‡Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China.|§College of Pharmacy, Harbin University of Commerce, Harbin 150076, People's Republic of China.
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D028481:Euphorbia / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010935:Plant Diseases / Q000382:microbiology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004224:Diterpenes; D010936:Plant Extracts
keywords: ECD calculations; Euphorbia prolifera; agrochemicals; antifungal activities; diterpenes