title: Copper-catalysed ring-opening trifluoromethylation of cyclopropanols.
abstract: A copper-catalysed ring-opening trifluoromethylation reaction of cyclopropanols has been developed. Various β-trifluoromethyl ketones are obtained in good to excellent yields under mild reaction conditions. The present method also exhibits good functional-group compatibility. The mechanism of this new ring-opening trifluoromethylation reaction was investigated by radical trapping reactions.
authors.affiliation: School of Medical Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, P. R. China. daijj@hfut.edu.cn hjxu@hfut.edu.cn.
authors.forename: Xia-Ping
authors.initials: XP
authors.lastname: He
authors.forename: Yong-Jin
authors.initials: YJ
authors.lastname: Shu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Dai
authors.forename: Wen-Man
authors.initials: WM
authors.lastname: Zhang
authors.forename: Yi-Si
authors.initials: YS
authors.lastname: Feng
authors.forename: Hua-Jian
authors.initials: HJ
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008745:Methylation
chemical_list: D004988:Ethers, Cyclic; D006845:Hydrocarbons, Fluorinated; C043657:cyclopropanol; D003300:Copper