title: The Association Between VEGF +936C/T and -634G/C Polymorphisms and Breast Cancer Susceptibility, Tumor Growth, and Metastases: Evidence From 20,728 Subjects.
abstract: The relation between the polymorphisms of vascular endothelial growth factor (VEGF) and breast cancer remains inconclusive. In our meta-analysis based on 10,340 breast cancer patients and 10,388 controls, we found breast cancer susceptibility was elevated in individuals carrying the VEGF +936C allele, especially in Asians, and the +936CC increases tumor growth. The G allele of -634G/C polymorphism reduces breast cancer susceptibility in Asians, and breast cancer patients of -634GG genotype has decreased tumor growth. These results suggest that both the VEGF +936C/T and -634G/C polymorphisms influence breast cancer susceptibility and tumor growth, instead of metastasis.
authors.affiliation: 1Department of Spine Surgery, PLA 425 Hospital , Sanya , China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Ma
authors.forename: Weiguo
authors.initials: W
authors.lastname: Hu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Yujing
authors.initials: Y
authors.lastname: Sun
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Teng
authors.forename: Qian
authors.initials: Q
authors.lastname: Qiao
mesh_terms: D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009362:Neoplasm Metastasis; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups / Q000208:ethnology / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Breast cancer; Meta-analysis; Polymorphisms; VEGF