title: Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.
abstract: Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
authors.affiliation: Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. kongyang@hku.hk.
authors.forename: Kongyang
authors.initials: K
authors.lastname: Ma
authors.affiliation: Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. lijingyi_tmmu@yahoo.com.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. fangyongfeitmmu@hotmail.com.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Pathology and Center of Infection and Immunology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China. liweilu@hku.hk.
authors.forename: Liwei
authors.initials: L
authors.lastname: Lu
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D051193:Toll-Like Receptors
keywords: B-1 B cells; Unc-93 Homolog B1 (C. elegans) (Unc93b1); anti-nuclear autoantibody (ANA); germinal center B cells (GC B cells); marginal zone B cells (MZ B cells); memory B cells; myeloid differentiation primary response gene 88 (MyD88); systemic lupus erythematosus (SLE); toll-like receptor (TLR); transitional B cells