title: Gender and ethnic differences in incidence and survival of lymphoid neoplasm subtypes in an Asian population: Secular trends of a population-based cancer registry from 1998 to 2012.
abstract: Descriptive epidemiology on incidence and survival by lymphoid neoplasm (LN) subtypes using the 2008 World Health Organisation (WHO) classification remained limited in Asia. The aim of this study was to evaluate whether gender and ethnic differences in incidence and survival of LN subtypes existed using the Singapore Cancer Registry (SCR) from 1998 to 2012. We derived age standardised incidence rates (ASIRs) by the direct standardisation method and 5-year relative survival (RSR) by the Ederer II method and period approach. Five-year observed survival (OS) was obtained for each ethnicity. Malays had the highest ASIR of total LNs among the three ethnicities for each time period. The largest increase in 5-year RSR subtypes was follicular lymphoma from 43.8% in 1998-2002 to 82.3% in 2008-2012; followed by chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma (SLL) from 48.1% in 1998-2002 to 77.9% in 2008-2012. Although males had higher incidence than females in each time period, females had greater 5-year RSR for follicular lymphoma (89.8% in 2008-2012 for females vs. 76.6% in 2008-2012 for males) and CLL/SLL (78.7% in 2008-2012 for females vs. 76.7% in 2008-2012 for males). All three ethnicities experienced an overall increase in 5-year OS for mature B-cell lymphoma, with Indians experiencing the greatest increase (37.1% in 1998-2002 to 61.1% in 2008-2012), followed by Malays (30.8% in 1998-2002 to 48.7% in 2008-2012) and then Chinese (36.4% in 1998-2002 to 51.3% in 2008-2012). Our study demonstrated that improved mature B-cell lymphoma survival was not only observed in the West, but also in Singapore.
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.|Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
authors.forename: Raymond Boon Tar
authors.initials: RB
authors.lastname: Lim
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.
authors.forename: En Yun
authors.initials: EY
authors.lastname: Loy
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.
authors.forename: Gek Hsiang
authors.initials: GH
authors.lastname: Lim
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.
authors.forename: Huili
authors.initials: H
authors.lastname: Zheng
authors.affiliation: National Registry of Diseases Office, Health Promotion Board, Singapore.
authors.forename: Khuan Yew
authors.initials: KY
authors.lastname: Chow
authors.affiliation: National Cancer Centre Singapore, SingHealth, Singapore.|Duke-National University of Singapore Graduate Medical School, Singapore.
authors.forename: Soon Thye
authors.initials: ST
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D005006:Ethnicity; D005260:Female; D006801:Humans; D015994:Incidence; D008223:Lymphoma / Q000453:epidemiology* / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012042:Registries; D012737:Sex Factors; D012846:Singapore / Q000453:epidemiology; D055815:Young Adult
keywords: Singapore; cancer registry; incidence; lymphoid neoplasm; lymphoma; survival