title: Functional topography of the human entorhinal cortex.
abstract: Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans.
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
authors.forename: Tobias
authors.identifier: http://orcid.org/0000-0001-6498-1846
authors.initials: T
authors.lastname: Navarro Schröder
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
authors.forename: Koen V
authors.initials: KV
authors.lastname: Haak
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
authors.forename: Nestor I
authors.initials: NI
authors.lastname: Zaragoza Jimenez
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Beckmann
authors.affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
authors.forename: Christian F
authors.initials: CF
authors.lastname: Doeller
mesh_terms: D000328:Adult; D000818:Animals; D003071:Cognition / Q000502:physiology; D063132:Connectome; D018728:Entorhinal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051379:Mice; D008959:Models, Neurological; D065854:Spatial Navigation / Q000502:physiology
keywords: entorhinal cortex; fMRI; human; medial temporal lobe; neuroscience