title: Toxic proteins in plants.
abstract: Plants have evolved to synthesize a variety of noxious compounds to cope with unfavorable circumstances, among which a large group of toxic proteins that play a critical role in plant defense against predators and microbes. Up to now, a wide range of harmful proteins have been discovered in different plants, including lectins, ribosome-inactivating proteins, protease inhibitors, ureases, arcelins, antimicrobial peptides and pore-forming toxins. To fulfill their role in plant defense, these proteins exhibit various degrees of toxicity towards animals, insects, bacteria or fungi. Numerous studies have been carried out to investigate the toxic effects and mode of action of these plant proteins in order to explore their possible applications. Indeed, because of their biological activities, toxic plant proteins are also considered as potentially useful tools in crop protection and in biomedical applications, such as cancer treatment. Genes encoding toxic plant proteins have been introduced into crop genomes using genetic engineering technology in order to increase the plant's resistance against pathogens and diseases. Despite the availability of ample information on toxic plant proteins, very few publications have attempted to summarize the research progress made during the last decades. This review focuses on the diversity of toxic plant proteins in view of their toxicity as well as their mode of action. Furthermore, an outlook towards the biological role(s) of these proteins and their potential applications is discussed.
authors.affiliation: Ghent University, Dept. Molecular Biotechnology, Laboratory Biochemistry and Glycobiology, 9000 Gent, Belgium. Electronic address: Liuyi.Dang@UGent.be.
authors.forename: Liuyi
authors.initials: L
authors.lastname: Dang
authors.affiliation: Ghent University, Dept. Molecular Biotechnology, Laboratory Biochemistry and Glycobiology, 9000 Gent, Belgium. Electronic address: Elsjm.VanDamme@UGent.be.
authors.forename: Els J M
authors.initials: EJM
authors.lastname: Van Damme
mesh_terms: D000818:Animals; D006801:Humans; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology; D010944:Plants / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D010940:Plant Proteins
keywords: Biological activity; Biotechnological application; Mode of action; Plant defense; Plant protein; Toxicity