title: Novel iron-based phosphate binders in patients with chronic kidney disease.
abstract: OBJECTIVE
  Management of hyperphosphatemia remains an integral component in the care of patients with chronic kidney disease on dialysis. In addition to dietary restriction and dialysis, oral phosphate binders remain a key strategy in the control of serum phosphorus levels in this population. We review two new oral phosphate binders that are currently marketed in the United States.
  
  
  RESULTS
  Sucroferric oxyhydroxide was approved by the U.S. Food and Drug Administration (FDA) in November 2013. A recent international, multicenter study found the drug to be efficacious and noninferior to sevelamer carbonate in magnitude of serum phosphate control. This was achieved with a significantly reduced daily pill burden for sucroferric oxyhydroxide. A second novel agent, ferric citrate was approved by the FDA in September, 2014. The drug was found to have similar phosphate control efficacy to active comparators and was superior to placebo. In addition, the drug delivers a significant amount of iron, resulting in improved erythropoietic parameters. Both drugs had diarrhea as a fairly frequent side-effect.
  
  
  CONCLUSIONS
  These new phosphate binders offer alternatives to currently available agents. Both have interesting properties that may make them particularly useful in clinical practice.
authors.affiliation: aDivision of Kidney Diseases and Hypertension, Department of Medicine, North Shore University Hospital bLong Island Jewish Medical Center, Hofstra North Shore-LIJ School of Medicine, Great Neck, New York, USA.
authors.forename: Hitesh H
authors.initials: HH
authors.lastname: Shah
authors.forename: Azzour D
authors.initials: AD
authors.lastname: Hazzan
authors.forename: Steven
authors.initials: S
authors.lastname: Fishbane
mesh_terms: D002614:Chelating Agents / Q000627:therapeutic use*; D006801:Humans; D054559:Hyperphosphatemia / Q000188:drug therapy*; D007501:Iron / Q000378:metabolism*; D010710:Phosphates / Q000097:blood*; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy*
chemical_list: D002614:Chelating Agents; D010710:Phosphates; D007501:Iron