title: Associations between plasma total homocysteine, blood pressure stages and pulse wave velocity in Chinese rural community population.
abstract: The aim of the study was to examine the associations among plasma total homocysteine (tHcy) and blood pressure (BP) stages and brachial-ankle pulse wave velocity (ba-PWV) in a Chinese rural community population. In this cross-sectional study, 2148 rural community subjects with normotension and mild hypertension (HTN) were classified into four groups according to ba-PWV level. Multivariate regression showed that ba-PWV was significantly and independently correlated with tHcy (β = 5.32, p < 0.001) in the entire study population. Moreover, ba-PWV showed a significant increase with increasing plasma tHcy level in subjects with both high normal BP and grade 1 HTN (p < 0.05). Compared with optimal BP stage, ba-PWV was significantly associated with high normal BP stage (β = 193, p < 0.001) and grade 1 HTN (β = 413, p < 0.001).There was a statistical interaction effect between high normal BP stage and optimal BP stage (p = 0.045). The similar result was found between subjects with optimal BP and those with grade 1 HTN (p = 0.037). In conclusion, tHcy was independently correlated with ba-PWV in subjects with high normal BP and grade 1 HTN. High normal BP and grade 1 HTN may worsen the impact of tHcy on arterial stiffness in a Chinese rural community population.
authors.affiliation: a Department of Cardiology , Chinese People's Liberation Army General Hospital , Beijing , China.
authors.forename: Geng
authors.initials: G
authors.lastname: Qian
authors.affiliation: a Department of Cardiology , Chinese People's Liberation Army General Hospital , Beijing , China.
authors.forename: Long-Huan
authors.initials: LH
authors.lastname: Zeng
authors.affiliation: a Department of Cardiology , Chinese People's Liberation Army General Hospital , Beijing , China.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: a Department of Cardiology , Chinese People's Liberation Army General Hospital , Beijing , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.affiliation: a Department of Cardiology , Chinese People's Liberation Army General Hospital , Beijing , China.
authors.forename: Yun-Dai
authors.initials: YD
authors.lastname: Chen
authors.affiliation: b Department of Cardiology , Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China.
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Zheng
authors.affiliation: b Department of Cardiology , Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China.
authors.forename: Xin-Chun
authors.initials: XC
authors.lastname: Yang
authors.affiliation: c Institute of Biomedicine, Anhui Medical University , Hefei , China.
authors.forename: Xi-Ping
authors.initials: XP
authors.lastname: Xu
authors.affiliation: d Department of Cardiology and Heart Center , Peking University First Hospital , Beijing , China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Huo
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001794:Blood Pressure; D002681:China; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D012424:Rural Population
chemical_list: D006710:Homocysteine
keywords: Homocysteine; hypertension; pulse wave velocity