title: Organocatalytic routes toward substituted 1,2,3-triazoles.
abstract: The present feature article describes the different organocatalytic routes for the synthesis of substituted 1,2,3-triazoles. This methodology has recently gained much attention due to its many advantages like high regioselectivity, substrate scope, high yields, and access to novel molecules. The review is divided into 4 different sections based on the active intermediate of the triazole synthesis reactions. The mechanism of each approach is critically discussed and in addition, the advantages and disadvantages of each method are described with relevant examples.
authors.affiliation: Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium. wim.dehaen@chem.kuleuven.be.
authors.forename: Jubi
authors.initials: J
authors.lastname: John
authors.forename: Joice
authors.initials: J
authors.lastname: Thomas
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000588:Amines; D007659:Ketones; D014230:Triazoles