title: Vasopressin regulation of sodium transport in the distal nephron and collecting duct.
abstract: Arginine vasopressin (AVP) is released from the posterior pituitary gland during states of hyperosmolality or hypovolemia. AVP is a peptide hormone, with antidiuretic and antinatriuretic properties. It allows the kidneys to increase body water retention predominantly by increasing the cell surface expression of aquaporin water channels in the collecting duct alongside increasing the osmotic driving forces for water reabsorption. The antinatriuretic effects of AVP are mediated by the regulation of sodium transport throughout the distal nephron, from the thick ascending limb through to the collecting duct, which in turn partially facilitates osmotic movement of water. In this review, we will discuss the regulatory role of AVP in sodium transport and summarize the effects of AVP on various molecular targets, including the sodium-potassium-chloride cotransporter NKCC2, the thiazide-sensitive sodium-chloride cotransporter NCC, and the epithelial sodium channel ENaC.
authors.affiliation: Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport (InterPrET), Aarhus University, Aarhus, Denmark;
authors.forename: M L A
authors.initials: ML
authors.lastname: Kortenoeven
authors.affiliation: Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark; and.
authors.forename: N B
authors.initials: NB
authors.lastname: Pedersen
authors.affiliation: Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: L L
authors.initials: LL
authors.lastname: Rosenbaek
authors.affiliation: Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport (InterPrET), Aarhus University, Aarhus, Denmark; robert.a.fenton@biomed.au.dk.
authors.forename: R A
authors.initials: RA
authors.lastname: Fenton
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D027682:Cation Transport Proteins / Q000378:metabolism*; D006801:Humans; D017136:Ion Transport; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D009318:Natriuresis; D009399:Nephrons / Q000378:metabolism*; D017483:Receptors, Vasopressin / Q000378:metabolism; D065667:Renal Elimination; D065608:Renal Reabsorption; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism*
chemical_list: D027682:Cation Transport Proteins; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin; D012964:Sodium
keywords: vasopressin