title: Chenodeoxycholic acid attenuates ovalbumin-induced airway inflammation in murine model of asthma by inhibiting the T(H)2 cytokines.
abstract: Asthma is a complex highly prevalent airway disease that is a major public health problem for which current treatment options are inadequate. Recently, farnesoid X receptor (FXR) has been shown to exert anti-inflammatory actions in various disease conditions, but there have been no reported investigations of Chenodeoxycholic acid (CDCA), a natural FXR agonist, in allergic airway inflammation. To test the CDCA effectiveness in airway inflammation, ovalbumin (OVA)-induced acute murine asthma model was established. We found that lung tissue express FXR and CDCA administration reduced the severity of the murine allergic airway disease as assessed by pathological and molecular markers associated with the disease. CDCA treatment resulted in fewer infiltrations of cells into the airspace and peribronchial areas, and decreased goblet cell hyperplasia, mucus secretion and serum IgE levels which was increased in mice with OVA-induced allergic asthma. The CDCA treatment further blocked the secretion of TH2 cytokines (IL-4, IL-5 and IL-13) and proinflammatory cytokine TNF-α indicate that the FXR and its agonists may have potential for treating allergic asthma.
authors.affiliation: Department of Zoology, Yogi Vemana University, Kadapa, 516 003 A.P., India.
authors.forename: Firdose Begum
authors.initials: FB
authors.lastname: Shaik
authors.affiliation: Department of Biotechnology, Govt. College for Men, Kadapa, A.P., India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Panati
authors.affiliation: Department of Zoology, Yogi Vemana University, Kadapa, 516 003 A.P., India.
authors.forename: Vydyanath R
authors.initials: VR
authors.lastname: Narasimha
authors.affiliation: Department of Zoology, Yogi Vemana University, Kadapa, 516 003 A.P., India. Electronic address: nvramireddy@gmail.com.
authors.forename: Venkata Ramireddy
authors.initials: VR
authors.lastname: Narala
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control*; D001483:Base Sequence; D001991:Bronchitis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D016207:Cytokines / Q000037:antagonists & inhibitors*; D017931:DNA Primers; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000008:administration & dosage*; D018418:Th2 Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D016207:Cytokines; D017931:DNA Primers; D002635:Chenodeoxycholic Acid; D010047:Ovalbumin
keywords: Airway inflammation; Farnesoid X receptor; Nuclear receptor; T(H)2 cytokines