title: Surfactant protein B gene polymorphisms is associated with risk of bronchopulmonary dysplasia in Chinese Han population.
abstract: OBJECTIVE
  To investigate the relationship between Surfactant protein B (SP-B) gene polymorphisms and bronchopulmonary dysplasia (BPD) development in preterm infants of China Han ethnic population.
  
  
  METHODS
  SP-B gene polymorphisms were studied in 134 neonates who were born at <32 weeks of gestation, with the diagnosis of BPD and in a control group of 168 preterm infants without BPD. Genotyping for SP-B was performed by polymerase chain reaction (PCR) and gene sequencing.
  
  
  RESULTS
  In this study, three of the SNP genotypes, -18C/A, 1580C/T and 4564T/C were common identified in SP-B gene. The -18C/A genotype was found to be significantly associated with BPD (χ2=10.741, P<0.01), with P<0.01 for the dominant model (OR=1.712, 95% CI=1.228-2.3894) and the allelic model (OR=1.787, 95% CI=1.276-2.502). The 1580C/T genotype was found to be associated with BPD (χ2=7.014, P<0.05), with P<0.05 for the dominant model (OR=0.752, 95% CI=0.593-0.954) and P<0.01 for the allelic model (OR=0.706, 95% CI=0.548-0.909). The 4564T/C genotypes and alleles were found not to be associated with BPD (χ2=3.399 and 3.227, P>0.05).
  
  
  CONCLUSIONS
  SP-B -18C/A and 1580C/T polymorphisms are associated with BPD. The 1580C/T polymorphism was protective while the -18C/A polymorphism increased the risk for BPD. SP-B 4564T/C polymorphism is not associated with BPD.
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Li
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Xiangyong
authors.initials: X
authors.lastname: Kong
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Yupei
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Wei
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Song
authors.affiliation: Affiliated Bayi Children's Hospital, General Military Hospital of Beijing PLA Beijing, China.
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Feng
mesh_terms: D044466:Asian People / Q000235:genetics*; D001997:Bronchopulmonary Dysplasia / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D020641:Polymorphism, Single Nucleotide; D037701:Pulmonary Surfactant-Associated Protein B / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D037701:Pulmonary Surfactant-Associated Protein B
keywords: Surfactant protein B; bronchopulmonary dysplasia; gene polymorphism