title: Temperature-Sensitive Intracellular Traffic of α2C-Adrenergic Receptor.
abstract: α(2C)-Adrenergic receptor (α(2C)-AR) is the least characterized adrenergic receptor subtype and still very little is known about the intracellular traffic properties and pathophysiological roles of this receptor. α(2C)-AR has an atypical subcellular localization. At 37 °C, in the vascular smooth muscle cells and in fibroblasts, the receptor is poorly localized at the plasma membrane and accumulates inside the cell. Exposure to lower temperatures stimulates α(2C)-AR transport to the cell surface. This particular intracellular trafficking of α(2C)-AR is significant in the pathology of Raynaud phenomenon. In this brief review, I will present general information on the tissue distribution and cellular localization of α(2C)-AR. Also, I will discuss the mechanisms involved in the receptor transport by focusing on the trafficking motifs and on the molecular chaperones.
authors.affiliation: Department of Pharmacology, College of Medicine, Howard University, Washington, District of Columbia, USA. Electronic address: catalin.filipeanu@howard.edu.
authors.forename: Catalin M
authors.initials: CM
authors.lastname: Filipeanu
mesh_terms: D000074183:ATPases Associated with Diverse Cellular Activities; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D004265:DNA Helicases / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D064448:Filamins / Q000378:metabolism; D057809:HEK293 Cells; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D008969:Molecular Sequence Data; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011928:Raynaud Disease / Q000378:metabolism* / Q000503:physiopathology; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D013696:Temperature; D014018:Tissue Distribution
chemical_list: D002352:Carrier Proteins; C578661:FLNC protein, human; D064448:Filamins; D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D018341:Receptors, Adrenergic, alpha-2; D000074183:ATPases Associated with Diverse Cellular Activities; D004265:DNA Helicases; C486549:RUVBL1 protein, human
keywords: Intracellular traffic; Molecular chaperones; Raynaud phenomenon; Temperature-sensitive; α(2C)-Adrenergic receptor