title: Hyperuricemia as a Potential Determinant of Metabolic Syndrome.
abstract: Recent studies have focused on hyperuricemia as a modulator for metabolic syndrome. Hyperuricemia has reported in many studies as a causal marker in a higher prevalence of metabolic syndrome. In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. High level of uric acid has been associated with metabolic syndrome, type 2 diabetes and cardiovascular diseases. Hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders. This review focus on the role of uric acid in the development of metabolic syndrome and onthe possible pathophysiology.
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju.
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Yadav
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju.
authors.forename: Eun Soo
authors.initials: ES
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju.
authors.forename: Hong Min
authors.initials: HM
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Lee
authors.affiliation: Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju.
authors.forename: Eunhee
authors.initials: E
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju ; Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju.
authors.forename: Choon Hee
authors.initials: CH
authors.lastname: Chung
keywords: Hypertension; Hyperuricemia; Metabolic syndrome; Obesity; Uric acid