title: The influence of anti-TNF therapy on the magnetic resonance enterographic parameters of Crohn's disease activity.
abstract: OBJECTIVE
  Magnetic resonance enterography (MRE) is a useful tool in assessing the transmural and extraintestinal lesions in Crohn's disease (CD). However, the influence of anti-tumor necrosis factor (anti-TNF) therapy on MRE features of CD severity remains unknown. The purpose of the study was to assess the short- and long-term changes in MRE features of CD activity in relation to CD clinical course in patients treated with anti-TNF antibodies.
  
  
  METHODS
  The influence on the most important parameters of CD activity seen in MRE was assessed retrospectively using a validated score. Patients were treated with anti-TNF agents and the clinical, laboratory, and MRE CD activity was estimated at baseline, after the induction therapy and after 1 year of treatment.
  
  
  RESULTS
  71 patients were enrolled in a study. The change in CD clinical activity correlated significantly with fluctuations in MRE activity score (P < 0.0001, r = 0.5 for induction; P = 0.004, r = 0.7 for maintenance anti-TNF therapy, respectively). Bowel wall thickening, mesenteric lymphadenopathy, and fat wrapping with vascular proliferation were MRE parameters which changed significantly both after the induction and maintenance treatment in patients responding to the therapy. The change in MRE activity score was mostly pronounced during the first 3 months of treatment, when compared to the continuation of the therapy till week 52-54 (-6 points vs. -2 points, respectively; P = 0.0008).
  
  
  CONCLUSIONS
  Transmural and extraintestinal healing seen in MRE correlates with changes in CD clinical activity during anti-TNF therapy, thus MRE seems to be a useful tool in monitoring the efficacy of biological agents.
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland. piotr.eder@op.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Eder
authors.affiliation: Department of General Radiology, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Katulska
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Iwona
authors.initials: I
authors.lastname: Krela-Kaźmierczak
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Kamila
authors.initials: K
authors.lastname: Stawczyk-Eder
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Klimczak
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szymczak
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Linke
authors.affiliation: Department of Gastroenterology, Human Nutrition and Internal Diseases, Heliodor Swiecicki Clinical Hospital, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznan, Poland.
authors.forename: Liliana
authors.initials: L
authors.lastname: Łykowska-Szuber
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use*; D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab / Q000627:therapeutic use*; D007422:Intestines / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000068879:Adalimumab
keywords: Anti-tumor necrosis factor alpha therapy; Crohn’s disease; Magnetic resonance enterography