title: Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat diet.
abstract: BACKGROUND
  Seeking better quality of life, the number of studies on functional foods and disease prevention is growing fast. Whole red grape juice (WRGJ) and red wine (RW) stand out, which are rich in polyphenols, showing antioxidant and anti-inflammatory activity.
  
  
  OBJECTIVE
  To evaluate the effect of WRGJ and RW intake and resveratrol solution (RS) on blood pressure and fat liver deposition of rats fed with high-fat diet.
  
  
  METHODS
  During 60 days, 50 Rattus norvegicus Wistar Albino adults were divided into: control group (CG)--balanced diet, hyperlipidic group (HG), red wine group (RWG), grape juice group (JGG) and resveratrol group (RG)--hyperlipidic diet. Feed and water were offered ad libttum to all groups. WRGJ, RW and RS were offered daily to JG, WG and RG, respectively. Blood pressure was measured using tail plestimograph. The animals were anesthetized, sacrificed and the liver was removed, weighed and fat was extracted using Soxhlet extractor.
  
  
  RESULTS
  No difference in weight gain, feed intake, liver weight and diastolic blood pressure among groups was observed. However, systolic blood pressure (mmHg) and liver fat concentration (g%) were lower (p<0.05) in JGG than in HG, WG and RG, but similar to CG.
  
  
  CONCLUSIONS
  The daily consumption of WRGJ minimizes the effects of high-fat diet on systolic blood pressure and prevents nonalcoholic fatty infiltration in the liver of animals, which was not observed in the consumption of RW or resveratrol solution.
authors.affiliation: Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Masters student.. teresabd@gmail.com.
authors.forename: Teresa
authors.initials: T
authors.lastname: Palmisciano Bedê
authors.affiliation: Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Undergraduate research student.. aclaudinhauff@gmail.com.
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Pascoal
authors.affiliation: Great River University (UNIGRANRIO). Undergraduate research student.. lucasfhas@gmail.com.
authors.forename: Lucas
authors.initials: L
authors.lastname: Hauaji Facó
authors.affiliation: Great River University (UNIGRANRIO). Undergraduate research student.. edu.s.c_1234@hotmail.com.
authors.forename: Eduardo
authors.initials: E
authors.lastname: de Salvo Castro
authors.affiliation: Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Doctorate student.. vaniamattoso@yahoo.com.br.
authors.forename: Vânia
authors.initials: V
authors.lastname: Mattoso
authors.affiliation: Rio de Janeiro Federal State University (UNIRIO). Nutrition School. Departament of Aplicated Nutrition.. julifd@gmail.com.
authors.forename: Juliana
authors.initials: J
authors.lastname: Furtado Dias
authors.affiliation: Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Nutrition School. Department of Nutrition and Dietetics, Brazil.. vilma.blondet@gmail.com.
authors.forename: Vilma
authors.initials: V
authors.lastname: Blondet de Azeredo
mesh_terms: D000818:Animals; D001628:Beverages; D001794:Blood Pressure / Q000187:drug effects*; D059305:Diet, High-Fat; D005260:Female; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy / Q000517:prevention & control; D059808:Polyphenols / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027843:Vitis; D014920:Wine
chemical_list: D059808:Polyphenols