title: Deciphering the BRCA1 Tumor Suppressor Network.
abstract: The BRCA1 tumor suppressor protein is a central constituent of several distinct macromolecular protein complexes that execute homology-directed DNA damage repair and cell cycle checkpoints. Recent years have borne witness to an exciting phase of discovery at the basic molecular level for how this network of DNA repair proteins acts to maintain genome stability and suppress cancer. The clinical dividends of this investment are now being realized with the approval of first-in-class BRCA-targeted therapies for ovarian cancer and identification of molecular events that determine responsiveness to these agents. Further delineation of the basic science underlying BRCA network function holds promise to maximally exploit genome instability for hereditary and sporadic cancer therapy.
authors.affiliation: Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, and Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Departments of Cancer Biology and Pathology, Abramson Family Cancer Research Institute, and Basser Research Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Electronic address: rogergr@mail.med.upenn.edu.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D001940:Breast / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D042822:Genomic Instability; D006801:Humans; D058990:Molecular Targeted Therapy; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D060066:Protein Interaction Maps
chemical_list: D019313:BRCA1 Protein
keywords: BRCA1; BRCA2; DNA damage response; DNA repair; breast cancer