title: Efficacy comparison between cryoablation and radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter: a meta-analysis.
abstract: We perform this meta-analysis to compare the efficacy and safety of cryoablation versus radiofrequency ablation for patients with cavotricuspid valve isthmus dependent atrial flutter. By searching EMBASE, MEDLINE, PubMed and Cochrane electronic databases from March 1986 to September 2014, 7 randomized clinical trials were included. Acute (risk ratio[RR]: 0.93; P = 0.14) and long-term (RR: 0.94; P = 0.08) success rate were slightly lower in cryoablation group than in radiofrequency ablation group, but the difference was not statistically significant. Additionally, the fluoroscopy time was nonsignificantly reduced (weighted mean difference[WMD]: -2.83; P = 0.29), whereas procedure time was significantly longer (WMD: 25.95; P = 0.01) in cryoablation group compared with radiofrequency ablation group. Furthermore, Pain perception during the catheter ablation was substantially less in cryoablation group than in radiofrequency ablation group (standardized mean difference[SMD]: -2.36; P < 0.00001). Thus, our meta-analysis demonstrated that cryoablation and radiofrequency ablation produce comparable acute and long-term success rate for patients with cavotricuspid valve isthmus dependent atrial flutter. Meanwhile, cryoablation ablation tends to reduce the fluoroscopy time and significantly reduce pain perception in cost of significantly prolonged procedure time.
authors.affiliation: Department of Cardiology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai, 200092, China.
authors.forename: Yi-He
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Respiratory, the second affiliated hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Neurology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai, 200092, China.
authors.forename: Cheng-Long
authors.initials: CL
authors.lastname: Xie
authors.affiliation: Department of Dermatology, the second affiliated hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Xinhua Hospital affiliated to the Medical School of Shanghai Jiaotong University, 1665 Kongjiang Road, Shanghai, 200092, China.
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001282:Atrial Flutter / Q000209:etiology* / Q000628:therapy*; D017115:Catheter Ablation / Q000009:adverse effects / Q000379:methods; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D058748:Pain Perception; D016896:Treatment Outcome; D014261:Tricuspid Valve / Q000473:pathology*