title: Patient reported outcomes of the -clinical use of a proprietary topical dry mouth product.
abstract: OBJECTIVE
  To present patient reported changes in oral symptoms in response to an open-label product trial conducted in patients self-identifying as having Sjögren's syndrome.
  
  
  METHODS
  A survey was conducted in conjunction with the Sjögren's Syndrome Foundation and 151 foundation members completed a survey rating their common oral symptoms, based upon the Vanderbilt Head and Neck Symptom Survey before and after use of the trial products, including rinse, -lozenges, gel, and spray.
  
  
  RESULTS
  Subjects reported multiple oral symptoms with the highest rated symptoms involving dry mouth with 80% of symptoms showing statistically significant reduction from pre- to posttest. The largest symptom reductions were in dry mouth symptoms and dietary problems.
  
  
  CONCLUSIONS
  Symptoms of dry mouth were improved with use of MedActive® products. Increased ease of taking oral medications also was reported. Improvement in mouth/throat pain was noted. Subjects reported considerable effect of the test product upon dry mouth and oral symptoms.
authors.affiliation: Diplomate, American Academy of Oral Medicine Collaborative Member, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles; Consultant, Division of Otolaryngology Head and Neck Surgery, City of Hope National Medical Center, CA.
authors.forename: Joel B
authors.initials: JB
authors.lastname: Epstein
authors.affiliation: Director of Research, Advocate Health Care, Chicago, IL.
authors.forename: Dana C
authors.initials: DC
authors.lastname: Villines
authors.affiliation: Diplomate, American Academy of Oral Medicine; Associate Professor and Chief of Oral Medicine, Department of Oral Medicine and Diagnostic Sciences, College of Dentistry University of Illinois at Chicago, Chicago, IL.
authors.forename: Herve Y
authors.initials: HY
authors.lastname: Sroussi
mesh_terms: D000287:Administration, Topical; D000368:Aged; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage*; D004338:Drug Combinations; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D000071066:Patient Reported Outcome Measures; D020442:Poloxamer / Q000008:administration & dosage*; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome; D014481:United States; D014987:Xerostomia / Q000188:drug therapy*
chemical_list: D004129:Dimethylpolysiloxanes; D004338:Drug Combinations; D004655:Emulsions; C000615751:Ultramulsion; D020442:Poloxamer; C501844:dimethicone
keywords: Sjögren's syndrome; dysguesia; mouth and throat pain; quality of life; salivation; xerostomia