title: Development of Chiral Spiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of β-Alkyl-β-Ketoesters.
abstract: The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of β-alkyl-β-ketoesters, producing chiral β-alkyl-β-hydroxyesters with excellent enantioselectivities (95-99.9% ee) and turnover numbers of up to 355,000.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn.
authors.forename: Deng-Hui
authors.initials: DH
authors.lastname: Bao
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Wu
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn.
authors.forename: Chao-Lun
authors.initials: CL
authors.lastname: Liu
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn. jhxie@nankai.edu.cn.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn. qlzhou@nankai.edu.cn.
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
keywords: asymmetric catalysis; hydrogenation; iridium; ketoesters; spiro ligands