title: A porphyrin photosensitized metal-organic framework for cancer cell apoptosis and caspase responsive theranostics.
abstract: A photosensitized and caspase-responsive multifunctional nanoprobe was designed by assembling a porphyrin, a folate targeting-motif and a dye-labelled peptide in a metal-organic framework (MOF) cage, which significantly increases the singlet oxygen quantum yield of porphyrin by 6.2 times, and achieves high efficient cancer therapy and in situ therapeutic monitoring with caspase-3 activation. The integration of theranostic functions in a single nanocarrier holds great promise in precision cancer diagnosis and treatment.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. jpl@nju.edu.cn hxju@nju.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianping
authors.initials: J
authors.lastname: Lei
authors.forename: Fengjiao
authors.initials: F
authors.lastname: Ma
authors.forename: Pinghua
authors.initials: P
authors.lastname: Ling
authors.forename: Jintong
authors.initials: J
authors.lastname: Liu
authors.forename: Huangxian
authors.initials: H
authors.lastname: Ju
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D009942:Organometallic Compounds / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000633:toxicity*; D011166:Porphyrins / Q000737:chemistry* / Q000633:toxicity; D026082:Singlet Oxygen / Q000378:metabolism; D000068936:Theranostic Nanomedicine
chemical_list: D004337:Drug Carriers; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen; D053148:Caspase 3