title: Gold-Catalyzed Reactions via Cyclopropyl Gold Carbene-like Intermediates.
abstract: Cycloisomerizations of 1,n-enynes catalyzed by gold(I) proceed via electrophilic species with a highly distorted cyclopropyl gold(I) carbene-like structure, which can react with different nucleophiles to form a wide variety of products by attack at the cyclopropane or the carbene carbons. Particularly important are reactions in which the gold(I) carbene reacts with alkenes to form cyclopropanes either intra- or intermolecularly. In the absence of nucleophiles, 1,n-enynes lead to a variety of cycloisomerized products including those resulting from skeletal rearrangements. Reactions proceeding through cyclopropyl gold(I) carbene-like intermediates are ideally suited for the bioinspired synthesis of terpenoid natural products by the selective activation of the alkyne in highly functionalized enynes or polyenynes.
authors.affiliation: †Institute of Chemical Research of Catalonia (ICIQ), Av Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Dorel
authors.affiliation: †Institute of Chemical Research of Catalonia (ICIQ), Av Països Catalans 16, 43007 Tarragona, Spain.|‡Departament de Química Analítica i Química Orgánica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Echavarren