title: Synthesis of Nanogels via Cell Membrane-Templated Polymerization.
abstract: The synthesis of biomimetic hydrogel nanoparticles coated with a natural cell membrane is described. Compared to the existing strategy of wrapping cell membranes onto pre-formed nanoparticle substrates, this new approach forms the cell membrane-derived vesicles first, followed by growing nanoparticle cores in situ. It adds significant controllability over the nanoparticle properties and opens unique opportunities for a broad range of biomedical applications.
authors.affiliation: Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.|Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Ronnie H
authors.initials: RH
authors.lastname: Fang
authors.affiliation: Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
authors.affiliation: Department of Nanoengineering and Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000737:chemistry; D004910:Erythrocyte Membrane / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008813:Mice, Inbred ICR; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011094:Polyethyleneimine / Q000138:chemical synthesis* / Q000737:chemistry; D058105:Polymerization
chemical_list: D003497:Cyclic N-Oxides; D000080385:Nanogels; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine; C003959:TEMPO
keywords: cell membranes; in situ polymerization; macromolecular inhibitors; nanogel; red blood cells