title: Development of Malignant Melanoma of the Orbit in Previous Radiation Field.
abstract: We present a case of a 40-year-old woman with a history of retinoblastoma in the left eye treated with enucleation and radiation therapy as an infant who recently developed worsening pain and exophthalmos in her right eye. Multimodality imaging demonstrated an enhancing, FDG-avid mass in the medial right orbit with associated bone destruction and extension into the ethmoid sinus. Pathologic analysis after excision showed a highly undifferentiated tumor consistent with melanoma. Although development of malignant melanoma in an irradiated field is rare, it should be considered in the differential, especially in childhood cancer survivors at increased risk of second malignant neoplasms.
authors.affiliation: From the Departments of *Radiology and †Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
authors.forename: Shamima
authors.initials: S
authors.lastname: Ahmed
authors.forename: Nicholas
authors.initials: N
authors.lastname: McDonald
authors.forename: Lindsey
authors.initials: L
authors.lastname: Lowder
authors.forename: Bruce
authors.initials: B
authors.lastname: Mahoney
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging* / Q000473:pathology; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18