title: Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics.
abstract: Computational fluid dynamics (CFD) was used to simulate air flow changes in reconstructed nasal passages based on magnetic resonance imaging (MRI) data from a previous clinical study of 0.05% Oxymetazoline (Vicks Sinex Micromist®). Total-pressure boundary conditions were uniquely applied to accommodate low patency subjects. Net nasal resistance, the primary simulation outcome, was determined using a parallel-circuit analogy and compared across treatments. Relative risk (RR) calculations show that for a 50% reduction in nasal resistance, subjects treated with Sinex® are 9.1 times more likely to achieve this after 8 hr, and 3.2 times more likely after 12 hr compared to Sham.
authors.forename: Aravind
authors.initials: A
authors.lastname: Kishore
authors.forename: Lauren
authors.initials: L
authors.lastname: Blake
authors.forename: Chengming
authors.initials: C
authors.lastname: Wang
authors.forename: Shan
authors.initials: S
authors.lastname: Ba
authors.forename: Gary
authors.initials: G
authors.lastname: Gross
mesh_terms: D006801:Humans; D057446:Hydrodynamics; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D014663:Nasal Decongestants / Q000494:pharmacology*; D059085:Nasal Sprays; D009666:Nose / Q000187:drug effects*; D010109:Oxymetazoline / Q000494:pharmacology*
chemical_list: D014663:Nasal Decongestants; D059085:Nasal Sprays; D010109:Oxymetazoline