title: Risk of Atherosclerosis in Patients with Ataxia Telangiectasia.
abstract: OBJECTIVE
  Evaluate the nutritional status, plasma concentration of vitamin E and markers of cardiovascular risk in ataxia telangiectasia (AT) patients.
  
  
  METHODS
  Cross-sectional study with 13 patients with AT and 22 healthy controls, evaluating the following factors: nutritional status, food intake, lipid profile, plasma concentration of vitamin E, malondialdehyde and high sensitivity C-reactive protein, linking them with atherosclerosis risk in AT patients.
  
  
  RESULTS
  Average age was 14.6 in the AT group, 30.8% were malnourished and 23.1% had stunting. A greater impairment of lean body mass was found in these patients. Concentrations of triglycerides (TG), total cholesterol (CT), LDL-c, non-HDL cholesterol (NHDL-c) were significantly higher in patients and HDL-c, lower. Vitamin E/total lipids and vitamin E/TG ratios were lower in the AT group, and significant inverse correlation between these ratios and NHDL-c, CT/HDL-c, and LDL-c/HDL-c, log TG/HDL-c was observed in the AT group. Alanine aminotransferase correlated directly and significantly with NHDL-c, CT/HDL-c and LDL-c/HDL-c, in patients.
  
  
  CONCLUSIONS
  The alterations of lipid metabolism biomarkers suggestive of atherosclerotic risk of male AT patients coupled with lower vitamin E/total lipids ratio and low lean body mass may complicate the clinical course of the disease and emphasizes the importance of multidisciplinary care, routine monitoring of cardiovascular biomarkers and appropriate nutritional guidance.
authors.forename: Itana Gomes Alves
authors.initials: IGA
authors.lastname: Andrade
authors.forename: Beatriz Tavares
authors.initials: BT
authors.lastname: Costa-Carvalho
authors.forename: Rosangela
authors.initials: R
authors.lastname: da Silva
authors.forename: Sonia
authors.initials: S
authors.lastname: Hix
authors.forename: Cristiane
authors.initials: C
authors.lastname: Kochi
authors.forename: Fabíola Isabel
authors.initials: FI
authors.lastname: Suano-Souza
authors.forename: Roseli Oselka Saccardo
authors.initials: ROS
authors.lastname: Sarni
mesh_terms: D000293:Adolescent; D000328:Adult; D001260:Ataxia Telangiectasia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D050197:Atherosclerosis / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006130:Growth Disorders / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008499:Medical Records; D018384:Oxidative Stress; D015995:Prevalence; D012306:Risk; D012737:Sex Factors; D013851:Thinness / Q000150:complications* / Q000453:epidemiology; D014811:Vitamin E Deficiency / Q000150:complications* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers