title: Improved neurologic outcomes after cardiac arrest with combined administration of vasopressin, steroids, and epinephrine compared to epinephrine alone.
abstract: OBJECTIVE
  Is a vasopressin, steroid, and epinephrine (VSE) protocol for in-hospital cardiac arrest resuscitation associated with better survival to hospital discharge with favourable neurologic outcome compared to epinephrine alone? Article chosen Mentzelopoulos S, Malachias S, Konstantopoulos D, et al. Vasopressin, steroids, and epinephrine and neurologically favorable survival after in-hospital cardiac arrest: a randomized clinical trial. JAMA 2013;310:270-9.
  
  
  OBJECTIVE
  To determine if a VSE protocol during cardiopulmonary resuscitation with hydrocortisone administration in patients with postresuscitative shock at 4 hours after return of spontaneous circulation would improve survival to hospital discharge with favourable neurologic outcome.
authors.affiliation: 1Emergency Medicine Residency Program,McGill University Health Centre,Montreal,QC.
authors.forename: Tudor
authors.initials: T
authors.lastname: Botnaru
authors.affiliation: 1Emergency Medicine Residency Program,McGill University Health Centre,Montreal,QC.
authors.forename: Tawfeeq
authors.initials: T
authors.lastname: Altherwi
authors.affiliation: 2Department of Emergency Medicine,Sir Mortimer B. Davis Jewish General Hospital,Montreal,QC.
authors.forename: Jerrald
authors.initials: J
authors.lastname: Dankoff
mesh_terms: D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006323:Heart Arrest / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014667:Vasopressins / Q000008:administration & dosage*
chemical_list: D005938:Glucocorticoids; D014667:Vasopressins; D004837:Epinephrine