title: Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort.
abstract: OBJECTIVE
  The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.
  
  
  METHODS
  Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].
  
  
  RESULTS
  In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].
  
  
  CONCLUSIONS
  During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest, Hungary veghzsuzsi@gmail.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Vegh
authors.affiliation: Gastrounit, Medical Section, Hvidovre University Hospital, Hvidovre, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Burisch
authors.affiliation: Gastroenterology Department, Slagelse University Hospital, Slagelse, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: Pedersen
authors.affiliation: Nicosia private practice, Cyprus.
authors.forename: I
authors.initials: I
authors.lastname: Kaimakliotis
authors.affiliation: IBD Centre ISCARE, Charles University, Prague, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Duricova
authors.affiliation: IBD Centre ISCARE, Charles University, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Bortlik
authors.affiliation: Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
authors.forename: K Kofod
authors.initials: KK
authors.lastname: Vinding
authors.affiliation: Department of Medicine, Amager Hospital, Amager, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Avnstrøm
authors.affiliation: Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.affiliation: Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
authors.forename: K R
authors.initials: KR
authors.lastname: Nielsen
authors.affiliation: First Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: K H
authors.initials: KH
authors.lastname: Katsanos
authors.affiliation: First Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: E V
authors.initials: EV
authors.lastname: Tsianos
authors.affiliation: Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Lakatos
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: D
authors.initials: D
authors.lastname: Schwartz
authors.affiliation: Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Odes
authors.affiliation: UO Gastroenterologia, Azienda Ospedaliera-Università di Padova, Padova, Italy On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: D'Incà
authors.affiliation: Degenza Breve Internistica e Centro M.I.C.I.-Azienda Ospedaliera Arcispedale S Maria Nuova, Reggio Emilia, Italy On behalf of the EpiCom Northern Italy centre based in Crema, Cremona, Firenze, Forlì & Padova and Reggio Emilia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Beltrami
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: G
authors.initials: G
authors.lastname: Kiudelis
authors.affiliation: Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: L
authors.initials: L
authors.lastname: Kupcinskap
authors.affiliation: Department of Gastroenterology, State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
authors.forename: A
authors.initials: A
authors.lastname: Jucov
authors.affiliation: Department of Gastroenterology, State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.
authors.forename: S
authors.initials: S
authors.lastname: Turcan
authors.affiliation: Hospital de Vale de Sousa, Porto, Portugal.
authors.forename: L F
authors.initials: LF
authors.lastname: Barros
authors.affiliation: Department of Gastroenterology, Hospital de São João, Porto, Portugal Department of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal MedInUP-Centre for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Magro
authors.affiliation: Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Lazar
authors.affiliation: Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Goldis
authors.affiliation: Department of Gastroenterology, Grupo de Investigación en Patología Digestiva, Instituto de Investigación Biomedica [IBI], Xerencia de Xestión Integrada de Vigo, SERGAS, Vigo, Spain.
authors.forename: L
authors.initials: L
authors.lastname: de Castro
authors.affiliation: Department of Gastroenterology, Grupo de Investigación en Patología Digestiva, Instituto de Investigación Biomedica [IBI], Xerencia de Xestión Integrada de Vigo, SERGAS, Vigo, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Hernandez
authors.affiliation: Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: O
authors.initials: O
authors.lastname: Niewiadomski
authors.affiliation: Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Bell
authors.affiliation: Department C, Gastroenterology Section, Herlev and Gentofte Hospital, Hellerup, Denmark.
authors.forename: E
authors.initials: E
authors.lastname: Langholz
authors.affiliation: Gastro Unit, Medical Section, North Zealand Hospital, University of Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Munkholm
authors.affiliation: First Department of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: P L
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia / Q000453:epidemiology; D003082:Colectomy / Q000706:statistics & numerical data*; D003131:Combined Modality Therapy; D016208:Databases, Factual; D005060:Europe / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: Inflammatory bowel diseases; hospitalization; surgery