title: Normocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism.
abstract: Normocalcemic primary hyperparathyroidism (NC-PHPT) is a variant of hyperparathyroidism, characterized by normal serum calcium levels, high parathyroid hormone (PTH) and normal 25-OH vitamin D status. The present study aimed to compare complications related to hyperparathyroidism in patients with NC-PHPT and hypercalcemic PHPT (HC-PHPT). We retrospectively evaluated the records of 307 PHPT patients between January 2010 and March 2013. We excluded patients with impaired renal function and liver failure. All patients underwent a biochemical and hormonal examination including serum glucose, albumin, total calcium, phosphorus, creatinine, lipoproteins, PTH and 25-OH vitamin D. Nephrolithiasis and bone mineral density were documented based on a review of the medical records. The study population consisted of 36 (12 %) males and 271 (88 %) females with a mean age of 53.3 ± 9.5 years (29-70 years). Twenty-three of the patients were diagnosed with NC-PHPT (group 1) and 284 were diagnosed with HC-PHPT (group 2). There were no significant differences in terms of age, gender, prevalence of hypertension, low bone mineral density and kidney stones between the groups. The mean thyroid-stimulating hormone (TSH) and low-density lipoprotein (LDL) levels were significantly higher in group 1 than in group 2. Our study found that patients with NC-PHPT have similar several complications as patients with HC-PHPT. NC-PHPT patients have higher TSH levels despite being within the normal range, and higher LDL-C levels than patients with HC-PHPT. However, this relationship needs to be clarified in future studies with larger cohorts.
authors.affiliation: Department of Endocrinology and Metabolism, Dicle University School of Medicine, Sur, Diyarbakır, Turkey. tunamazhar@gmail.com.
authors.forename: Mazhar Müslüm
authors.identifier: http://orcid.org/0000-0001-5975-7786
authors.initials: MM
authors.lastname: Tuna
authors.affiliation: Endocrinology and Metabolism Department, Dışkapı Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çalışkan
authors.affiliation: Endocrinology and Metabolism Department, Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ünal
authors.affiliation: Endocrinology and Metabolism Department, Dışkapı Training and Research Hospital, Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Demirci
authors.affiliation: Endocrinology and Metabolism Department, Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Berçem Ayçiçek
authors.initials: BA
authors.lastname: Doğan
authors.affiliation: Endocrinology and Metabolism Department, Hitit University School of Medicine, Çorum, Turkey.
authors.forename: Kerim
authors.initials: K
authors.lastname: Küçükler
authors.affiliation: Endocrinology and Metabolism Department, Dışkapı Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Özbek
authors.affiliation: Endocrinology and Metabolism Department, Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Berker
authors.affiliation: Endocrinology and Metabolism Department, Dışkapı Training and Research Hospital, Ankara, Turkey.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibaşı
authors.affiliation: Endocrinology and Metabolism Department, Hitit University School of Medicine, Çorum, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Güler
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications / Q000628:therapy; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications / Q000628:therapy; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood*
chemical_list: D008077:Lipoproteins, LDL; D013972:Thyrotropin
keywords: Kidney stones; Normocalcemia; Osteoporosis; Parathormone; Primary hyperparathyroidism