title: SecA: a potential antimicrobial target.
abstract: There is a consensus in the medical profession of the pressing need for novel antimicrobial agents due to issues related to drug resistance. In practice, solutions to this problem to a large degree lie with the identification of new and vital targets in bacteria and subsequently designing their inhibitors. We consider SecA a very promising antimicrobial target. In this review, we compile and analyze information available on SecA to show that inhibition of SecA has a multitude of consequences. Furthermore, we discuss issues critical to the design and evaluation of SecA inhibitors.
authors.affiliation: Department of Chemistry, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Arpana S
authors.initials: AS
authors.lastname: Chaudhary
authors.affiliation: Department of Chemistry, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Weixuan
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Biology, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Jinshan
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Biology, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Phang C
authors.initials: PC
authors.lastname: Tai
authors.affiliation: Department of Chemistry, Center for Diagnostics & Therapeutics, & Center for Biotechnology & Drug Design, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D000069816:SEC Translocation Channels; D000081416:SecA Proteins
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins