title: Doppler ultrasound measurement of resistance index in the diagnosis of prostate cancer.
abstract: Prostate cancer (PCa) remains the second leading cause of cancer diagnosis worldwide. Early diagnosis and treatment of PCa is critical since the long-term prognosis is excellent in patients with tumors confined to the prostate gland. The current meta-analysis investigates the diagnostic value of resistive index (RI) measurement using color Doppler ultrasound in patients with PCa. Electronic literature databases were exhaustively searched for relevant studies published prior to May 31, 2014. Nine studies met our predetermined inclusion criteria for the present meta-analysis. The methodologic quality of the selected studies was independently assessed by 2 reviewers based on Quality Assessment of Diagnostic Accuracy Studies tool. Our meta-analysis results showed that RI values were significantly higher in malignant prostate tissues compared to normal prostate tissues (standardized mean difference [SMD] 0.42, 95% confidence interval [CI] 0.12~0.73, p = 0.007) and benign prostate tissues (SMD 0.41, 95% CI 0.26~0.56, p<0.001). Subgroup analysis based on the diagnostic instruments used revealed that RI values were accurate in diagnosis of PCa when compared between malignant tissue vs normal tissue and malignant tissue vs benign tissue (all p<0.05). Taken together, our findings support the potential clinical applications of RI values in diagnosis of PCa.
authors.affiliation: Department of Urology, Hainan Provincial People`s Hospital, Hainan - PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Urology, Hainan Provincial People`s Hospital, Hainan - PR China.
authors.forename: Son
authors.initials: S
authors.lastname: Cen
authors.affiliation: Department of Urology, Hainan Provincial People`s Hospital, Hainan - PR China.
authors.forename: Xin-Li
authors.initials: XL
authors.lastname: Kang
authors.affiliation: Department of Urology, Hainan Provincial People`s Hospital, Hainan - PR China.
authors.forename: Wei Fu
authors.initials: WF
authors.lastname: Wang
authors.affiliation: Department of Urology, Hainan Provincial People`s Hospital, Hainan - PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, Xiangya Hospital Central South University, Hunan - PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
mesh_terms: D019160:Endosonography; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000473:pathology; D012007:Rectum; D012107:Research Design / Q000592:standards; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance