title: Palladium-Catalyzed Domino Addition and Cyclization of Arylboronic Acids with 3-Hydroxyprop-1-yn-1-yl Phosphonates Leading to 1,2-Oxaphospholenes.
abstract: A novel and efficient palladium-catalyzed domino addition-cyclization of a wide range of arylboronic acids with various 3-hydroxyprop-1-yn-1-yl phosphonates has been developed, affording a convenient and powerful tool for the preparation of valuable 1,2-oxaphospholenes with mild reaction conditions, broad substrate applicability, and good to excellent yields. Mechanistic studies revealed that the reaction might involve Michael addition and nucleophilic substitution.
authors.affiliation: †Department of Chemical Biology, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Lv
authors.affiliation: ‡Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Gaobo
authors.initials: G
authors.lastname: Hu
authors.affiliation: §Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Dumei
authors.initials: D
authors.lastname: Ma
authors.affiliation: ‡Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Liu Leo
authors.initials: LL
authors.lastname: Liu
authors.affiliation: ‡Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Gao
authors.affiliation: †Department of Chemical Biology, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.|‡Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium
chemical_list: D001897:Boronic Acids; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010165:Palladium