title: Spatio-temporal analysis of female breast cancer incidence in Shenzhen, 2007-2012.
abstract: BACKGROUND
  Breast cancer is a leading tumor with a high mortality in women. This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.
  
  
  METHODS
  The data on breast cancer incidence were obtained from the Shenzhen Cancer Registry System. To describe the temporal trend, the average annual percentage change (AAPC) was analyzed using a joinpoint regression model. Spatial autocorrelation and a retrospective spatio-temporal scan approach were used to detect the spatio-temporal cluster distribution of breast cancer cases.
  
  
  RESULTS
  Breast cancer ranked first among different types of cancer in women in Shenzhen between 2007 and 2012 with a crude incidence of 20.0/100,000 population. The age-standardized rate according to the world standard population was 21.1/100,000 in 2012, with an AAPC of 11.3%. The spatial autocorrelation analysis showed a spatial correlation characterized by the presence of a hotspot in south-central Shenzhen, which included the eastern part of Luohu District (Donghu and Liantang Streets) and Yantian District (Shatoujiao, Haishan, and Yantian Streets). Five spatio-temporal cluster areas were detected between 2010 and 2012, one of which was a Class 1 cluster located in southwestern Shenzhen in 2010, which included Yuehai, Nantou, Shahe, Shekou, and Nanshan Streets in Nanshan District with an incidence of 54.1/100,000 and a relative risk of 2.41; the other four were Class 2 clusters located in Yantian, Luohu, Futian, and Longhua Districts with a relative risk ranging from 1.70 to 3.25.
  
  
  CONCLUSIONS
  This study revealed the spatio-temporal cluster pattern for the incidence of female breast cancer in Shenzhen, which will be useful for a better allocation of health resources in Shenzhen.
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P. R. China. zhbsmail@126.com.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Zhou
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong, 518054, P. R. China. liushenglb@126.com.
authors.forename: Sheng-Yuan
authors.initials: SY
authors.lastname: Liu
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P. R. China. szleilin@qq.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Lei
authors.affiliation: Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong, 518054, P. R. China. ccdcchenzw@126.com.
authors.forename: Zhong-Wei
authors.initials: ZW
authors.lastname: Chen
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P. R. China. pengji126@126.com.
authors.forename: Ji
authors.initials: J
authors.lastname: Peng
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P. R. China. szyyz@china.com.
authors.forename: Ying-Zhou
authors.initials: YZ
authors.lastname: Yang
authors.affiliation: Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P. R. China. liuxl36@126.com.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Liu
mesh_terms: D001943:Breast Neoplasms; D002681:China; D005260:Female; D006801:Humans; D015994:Incidence; D012189:Retrospective Studies; D062206:Spatial Analysis; D062211:Spatio-Temporal Analysis