title: The Clinical Features and Bacteriological Characterizations of Bone and Joint Tuberculosis in China.
abstract: Bone and Joint tuberculosis (BJTB) constitutes about 10% of total extra-pulmonary TB cases. Since the BJTB is a paucibacillary condition, there has been no systematic study on the bacterial characterization, especially the epidemiological feature. Here we collected the mycobacterial clinical isolates, analyzed the clinical features and the bacteriological characteristics from 113 BJTB cases reported in China. The mean age of the cases was 40.33 years while most of the patients fell into the 20-29 year age group; local pain was the most common onset symptom of BJTB cases; mean time from symptom onset to BJTB diagnosis was 13.16 months. 31 isolates were defined as drug resistant, including 15 multidrug resistant (MDR) and 2 extensively drug resistant (XDR) isolates according to the drug susceptibility test outcomes; after spoligotyping, 87.6% (99/113) isolates were categorized as Beijing family. In contrast to the isolates from pulmonary tuberculosis patients, here the MIRU-VNTR assay did not find anything significant. A prolonged time span for BJTB diagnosis highlights the requirement of paying further attention to BJTB infection in China. This study provides essential insights into the demographic and microbial characteristics of BJTB cases in China.
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Su-Ting
authors.initials: ST
authors.lastname: Chen
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedics, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing China 101149.
authors.forename: Wei-Jie
authors.initials: WJ
authors.lastname: Dong
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Gu
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Yun-Xu
authors.initials: YX
authors.lastname: Li
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Dong
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Ma
authors.affiliation: Department of Orthopaedics, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing China 101149.
authors.forename: Shi-Bing
authors.initials: SB
authors.lastname: Qin
authors.affiliation: National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-resistant Tuberculosis Research.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D001842:Bone and Bones / Q000382:microbiology* / Q000473:pathology; D002648:Child; D002681:China; D021901:DNA, Intergenic / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005260:Female; D006801:Humans; D007596:Joints / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D012189:Retrospective Studies; D014394:Tuberculosis, Osteoarticular / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D021901:DNA, Intergenic; D012336:RNA, Ribosomal, 16S; D012338:RNA, Ribosomal, 23S