title: Adrenomedullin-RAMP2 System in Vascular Endothelial Cells.
abstract: Vascular endothelial cells play key roles in maintaining vascular and organ homeostasis. Adrenomedullin (AM), originally identified as a vasodilating peptide, is now recognized to be a pleiotropic molecule involved in both circulatory homeostasis and the pathogenesis of cardiovascular diseases. We have reported that knockout mice deficient in AM or receptor activity-modifying protein 2 (RAMP2), an AM-receptor accessory protein, show vascular endothelial cell deformities that are embryonically lethal. To directly clarify the pathophysiological functions of the vascular AM-RAMP2 system, we generated vascular endothelial cell-specific RAMP2 knockout mice. Using these mice, we found that the AM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood. This review highlights the functions of AM-RAMP2 in vascular endothelial cells.
authors.affiliation: Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science. 2) Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Nagano, Japan.
authors.forename: Teruhide
authors.initials: T
authors.lastname: Koyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sakurai
authors.forename: Akiko
authors.initials: A
authors.lastname: Kamiyoshi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Ichikawa-Shindo
authors.forename: Hisaka
authors.initials: H
authors.lastname: Kawate
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shindo
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D042783:Endothelial Cells / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D018345:Mice, Knockout; D058263:Receptor Activity-Modifying Protein 2 / Q000032:analysis / Q000502:physiology*
chemical_list: C545503:RAMP2 protein, human; D058263:Receptor Activity-Modifying Protein 2; D053607:Adrenomedullin