title: Antiangiogenic activity of mononuclear copper(II) polypyridyl complexes for the treatment of cancers.
abstract: A series of four new mononuclear copper(II) polypyridyl complexes (1-4) have been designed, developed, and thoroughly characterized by several physicochemical techniques. The CT-DNA binding properties of 1-4 have been investigated by absorption, emission spectroscopy, and viscosity measurements. All the complexes especially 1 and 4 exhibit cytotoxicity toward several cancer cell lines, suggesting their anticancer properties as observed by several in vitro assays. Additionally, the complexes show inhibition of endothelial cell (HUVECs) proliferation, indicating their antiangiogenic nature. In vivo chick embryo angiogenesis assay again confirms the antiangiogenic properties of 1 and 4. The formation of excessive intracellular ROS (H2O2 and O2(•-)) and upregulation of BAX induced by copper(II) complexes may be the plausible mechanisms behind their anticancer activities. The present study may offer a basis for the development of new transition metal complexes through suitable choice of ligands for cancer therapeutics by controlling tumor angiogenesis.
authors.forename: Penumaka
authors.initials: P
authors.lastname: Nagababu
authors.affiliation: ‡Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.forename: Bathini
authors.initials: B
authors.lastname: Thulasiram
authors.affiliation: §Department of Chemistry, National Dong Hwa University, Hualien, Taiwan ROC.
authors.forename: C Shobha
authors.initials: CS
authors.lastname: Devi
authors.affiliation: ∥Department of Chemistry, Osmania University, Tarnaka, Hyderabad 500007, Telangana State India.
authors.forename: S
authors.initials: S
authors.lastname: Satyanarayana
authors.affiliation: ‡Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
authors.forename: Bojja
authors.initials: B
authors.lastname: Sreedhar
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002453:Cell Cycle / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D053837:DNA Cleavage / Q000187:drug effects; D005434:Flow Cytometry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011485:Protein Binding; D011725:Pyridines / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011725:Pyridines; D017382:Reactive Oxygen Species; D003300:Copper; D004247:DNA; C427203:calf thymus DNA; C023666:pyridine