title: Interleukin-8-producing primary cardiac undifferentiated sarcoma in a child with sustained fever.
abstract: We report the case of a 12-year-old boy with primary undifferentiated sarcoma of the left atrium. He had sustained fever during the clinical course and multiple lung and brain metastases. Chemotherapy and irradiation were ineffective; he died 41 days after hospitalization. On retrospective analysis, interleukin-8 (IL-8) was elevated; this was supported by immunohistochemistry and gene expression analysis of tumor samples. IL-8 continued to increase with tumor progression accompanied by elevated neutrophil count and C-reactive protein. IL-8 is involved in malignant tumor proliferation, migration, and angiogenesis and may have been related to the clinical condition and prognosis in the present case.
authors.affiliation: Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.|Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Ryu
authors.initials: R
authors.lastname: Yanagisawa
authors.affiliation: Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.|Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Division of Clinical Pathology, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ogiso
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hachiya
authors.affiliation: Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.|Department of Pediatric Intensive Care, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Fujihara
authors.affiliation: Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Morita
authors.affiliation: Division of Hematology/Oncology, Nagano Children's Hospital, Azumino, Japan.|Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakashita
authors.affiliation: Department of Pediatric Intensive Care, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Kitamura
authors.affiliation: Department of Pediatric Intensive Care, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Hikoro
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Fumie
authors.initials: F
authors.lastname: Nishijima
authors.affiliation: Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hayashi
authors.affiliation: Life Science Research Center, Nagano Children's Hospital, Azumino, Japan.|Department of Laboratory Medicine, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Eiko
authors.initials: E
authors.lastname: Hidaka
authors.affiliation: Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sano
authors.affiliation: Department of Pediatrics, Matsumoto Dental University School of Dentistry, Shiojiri, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Shiohara
authors.affiliation: Division of Pediatric Cardiology, Nagano Children's Hospital, Azumino, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yasukochi
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D004453:Echoencephalography; D017809:Fatal Outcome; D005334:Fever / Q000209:etiology; D006325:Heart Atria / Q000473:pathology*; D006338:Heart Neoplasms / Q000097:blood / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000097:blood* / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012509:Sarcoma / Q000097:blood / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8
keywords: interleukin-8; left atrium; metastasis; primary cardiac tumor; undifferentiated sarcoma