title: Association of angiotensin ІІ type 1 receptor (A1166C) polymorphism with breast cancer risk: An update meta-analysis.
abstract: OBJECTIVE
  Previous studies on the relationship between angiotensin ІІ type 1 receptor (AT1R) gene (A1166C) polymorphism and breast cancer did not reach the same conclusion. In the present study, we aimed to further evaluate the relationship between the AT1R gene A1166C polymorphism and breast cancer risk.
  
  
  METHODS
  We selected five case-control studies related to AT1R gene A1166C polymorphism and breast cancer by searching PubMed, EMBase, Chinese Biomedical Literature Database, Chinese CNKI, Web of Science, and the Wanfang database. We utilized Q-test and I(2) test to detect the heterogeneity between each study. A random-effects model (I(2) > 50%; p < 0.10) or a fixed-effects model (I(2) < 50%; p > 0.10) was utilized to merge the odds ratio (OR) and 95% confidence interval (CI) during the meta- analyses.
  
  
  RESULTS
  The present study included 972 patients with breast cancer and 1336 cancer-free control subjects. By meta-analysis, we found A1166C polymorphism was associated with decreased risk for breast cancer in Caucasian population in an additive model (C vs. T: OR = 0.77, 95% CI: 0.62-0.96, p = 0.02). However, we did not find associations in other genetic models (AC+CC vs. AA: OR = 0.78, 95% CI: 0.50-1.22, p = 0.28; CC vs. AA+AC: OR = 1.64, 95% CI: 0.94-2.85, p = 0.08).
  
  
  CONCLUSIONS
  We concluded that AT1R gene A1166C polymorphism was associated with reduced risk for breast cancer.
authors.affiliation: Department of Oncology, 88 Hospital of PLA, Tai'an, People's Republic of China.
authors.forename: Fangguo
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, Suncun Hospital of Shandong Xinwen Mining Group, Xintai, People's Republic of China.
authors.forename: Guiling
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Radiotherapy, Shandong University Affiliated Jinan Central Hospital, Ji'nan, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Dou
authors.affiliation: Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, People's Republic of China xxy3169@163.com.
authors.forename: Xinyun
authors.initials: X
authors.lastname: Xu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D044140:Receptor, Angiotensin, Type 1
keywords: Breast cancer; angiotensin ІІ type 1 receptor; gene polymorphism; meta-analysis