title: Psychotic and depressive symptoms after gabapentin treatment.
abstract: Gabapentin, one of the antiepileptics, shows its effects via voltage-gated calcium channels. Sedation and mood elevation are among its side effects. The positive effects of antiepileptics such as valproate and carbamazepine as mood stabilizers have raised the hope that other antiepileptics may as well be efficacious in the treatment of mood disorders. However, relevant research data have not proven success of newer antiepileptics. This article presents the negative side effects of gabapentin such as psychotic and depressive symptoms, which occur shortly after its use. The use of gabapentin in mood disorders is discussed through these side effects.
authors.affiliation: Üsküdar University, Istanbul, Turkey alperevrensel@gmail.com.
authors.forename: Alper
authors.initials: A
authors.lastname: Evrensel
authors.affiliation: Üsküdar University, Istanbul, Turkey.
authors.forename: Barış Önen
authors.initials: BÖ
authors.lastname: Ünsalver
mesh_terms: D000588:Amines / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids / Q000009:adverse effects*; D003863:Depression / Q000139:chemically induced*; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects*
chemical_list: D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
keywords: Gabapentin; depression; psychosis; side effects