title: Comparative analysis of the Mycoplasma capricolum subsp. capricolum GM508D genome reveals subrogation of phase-variable contingency genes and a novel integrated genetic element.
abstract: Mycoplasma capricolum subspecies capricolum is both a pathogen of small ruminants and a model recipient organism for gene transplantation and synthetic biology. With the availability of the complete genome of the type strain California kid (released in 2005), a draft genome of strain GM508D was determined to investigate genomic variation in this subspecies. Differences in mobile genetic element location and complement, catabolic pathway genes, contingency loci, surface antigen genes and type II restriction-modification systems highlight the plasticity and diversity within this taxon.
authors.affiliation: Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA calcuttm@missouri.edu.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Calcutt
authors.affiliation: Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Mark F
authors.initials: MF
authors.lastname: Foecking
mesh_terms: D000940:Antigenic Variation; D023061:Gene Order; D005798:Genes, Bacterial; D014644:Genetic Variation; D016680:Genome, Bacterial; D020071:Interspersed Repetitive Sequences; D008969:Molecular Sequence Data; D045623:Mycoplasma capricolum / Q000235:genetics*; D017422:Sequence Analysis, DNA
keywords: Mycoplasma capricolum; antigenic variation; comparative genomics; mobile genetic element; restriction–modification; surface antigen