title: A five-membered lactone prodrug of CBI-based analogs of the duocarmycins.
abstract: The preparation, characterization and examination of the CBI-based 5-membered lactone5capable of serving as a prodrug or protein (antibody) conjugation reagent are disclosed along with its incorporation into the corresponding CC-1065 and duocarmycin analog6, and the establishment of their properties.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Mika
authors.initials: M
authors.lastname: Uematsu
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Brody
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
keywords: CBI; CC-1065; duocarmycin; prodrug