title: Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington's Disease Mouse Model R6/2.
abstract: Huntington's disease (HD) is a neurodegenerative illness, where selective neuronal loss in the brain caused by expression of mutant huntingtin protein leads to motor dysfunction and cognitive decline in addition to peripheral metabolic changes. In this study we confirm our previous observation of impairment of lactate-based hepatic gluconeogenesis in the transgenic HD mouse model R6/2 and determine that the defect manifests very early and progresses in severity with disease development, indicating a potential to explore this defect in a biomarker context. Moreover, R6/2 animals displayed lower blood glucose levels during prolonged fasting compared to wild type animals.
authors.affiliation: Section of Neurogenetics, Institute of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Signe Marie Borch
authors.initials: SM
authors.lastname: Nielsen
authors.affiliation: Section of Neurogenetics, Institute of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lis
authors.initials: L
authors.lastname: Hasholt
authors.affiliation: Section of Neurogenetics, Institute of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Nørremølle
authors.affiliation: The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark.
authors.forename: Knud
authors.initials: K
authors.lastname: Josefsen