title: Complementary and Alternative Therapies for Autism Spectrum Disorder.
abstract: Background. Complementary and alternative medicine (CAM) represents a popular therapeutic option for patients with autism spectrum disorder (ASD). Unfortunately, there is a paucity of data regarding the efficacy of CAM in ASD. The aim of the present systematic review is to investigate trials of CAM in ASD. Material and Methods. We searched the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, CINAHL, Psychology and Behavioral Sciences Collection, Agricola, and Food Science Source. Results. Our literature search identified 2687 clinical publications. After the title/abstract screening, 139 publications were obtained for detailed evaluation. After detailed evaluation 67 studies were included, from hand search of references we retrieved 13 additional studies for a total of 80. Conclusion. There is no conclusive evidence supporting the efficacy of CAM therapies in ASD. Promising results are reported for music therapy, sensory integration therapy, acupuncture, and massage.
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Natascia
authors.identifier: 0000-0002-3128-1592
authors.initials: N
authors.lastname: Brondino
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Fusar-Poli
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Rocchetti
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Provenzani
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Barale
authors.affiliation: Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Via Bassi 21, 27100 Pavia, Italy.
authors.forename: Pierluigi
authors.identifier: 0000-0002-4602-2032
authors.initials: P
authors.lastname: Politi