title: T-ALL: Home Is where the CXCL12 Is.
abstract: T cell acute lymphoblastic leukemia (T-ALL) is caused by mutations affecting cell survival, proliferation, and differentiation. In addition to requiring these mutations, Passaro and colleagues and Pitt and colleagues in this issue of Cancer Cell demonstrate that T-ALL initiating cells residing in bone marrow depend on the CXCR4/CXCL12 signaling axis for disease maintenance and progression.
authors.affiliation: VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; KU Leuven Center for Human Genetics, 3000 Leuven, Belgium. Electronic address: charles.debock@cme.vib-kuleuven.be.
authors.forename: Charles E
authors.initials: CE
authors.lastname: de Bock
authors.affiliation: VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; KU Leuven Center for Human Genetics, 3000 Leuven, Belgium. Electronic address: jan.cools@cme.vib-kuleuven.be.
authors.forename: Jan
authors.initials: J
authors.lastname: Cools
mesh_terms: D000818:Animals; D054377:Chemokine CXCL12 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology*; D011725:Pyridines / Q000494:pharmacology*; D019718:Receptors, CXCR4 / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12; D011725:Pyridines; D019718:Receptors, CXCR4