title: Frey procedure for chronic pancreatitis: Evidence-based assessment of short- and long-term results in comparison to pancreatoduodenectomy and Beger procedure: A meta-analysis.
abstract: OBJECTIVE
  Patients with chronic pancreatitis often require surgical treatment. The aim of this study was to evaluate the published evidence for Frey procedure in patients with chronic pancreatitis.
  
  
  METHODS
  Literature search was undertaken to identify eligible studies until February 2015. Using meta-analytical techniques, Frey procedure was compared with pancreatoduodenectomy or Beger procedure, and the short- and long-term outcomes were analysed.
  
  
  RESULTS
  Twenty-three studies comprising a total of 800 patients were reviewed. The postoperative morbidity and mortality were 23.2% and 0.4% respectively. The percentage of postoperative pain-relief patients was 89.4%. New onset of diabetes and exocrine insufficiency was present in 17.3% and 30.7% of patients, respectively. Compared with pancreatoduodenectomy, Frey procedure had favorable outcomes in terms of operation time, blood transfusion, overall morbidity, length of hospital and intensive care unit stay, pancreatic function and quality of life. Compared with Beger procedure, Frey procedure had shorter operation time and lower morbidity.
  
  
  CONCLUSIONS
  Frey procedure is a safe and effective surgical procedure for chronic pancreatitis with dilated duct in the absence of neoplasia.
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: General Intensive Care Unit, Songjiang Central Hospital, First People's Hospital of Shanghai Jiaotong University, Shanghai, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Lupeng
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary & Pancreatovascular Surgery, First affiliated Hospital of Xiamen University, Xiamen, China.
authors.forename: Xiurong
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu Province, China. Electronic address: ymli1962@sina.cn.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Li
mesh_terms: D019317:Evidence-Based Medicine; D006801:Humans; D010180:Pancreatectomy / Q000379:methods; D010183:Pancreatic Ducts / Q000473:pathology; D016577:Pancreaticoduodenectomy / Q000009:adverse effects / Q000379:methods*; D010193:Pancreaticojejunostomy / Q000379:methods; D050500:Pancreatitis, Chronic / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000628:therapy; D016896:Treatment Outcome
keywords: Beger procedure; Chronic pancreatitis; Complication; Frey procedure; Meta-analysis; Pancreatoduodenectomy