title: Disorders of sexual development.
abstract: Disorders of sexual development (DSDs) are a group of disorders in which there is discordance between anatomic or hormonal sex and sex chromosome complement. These disorders present with ambiguity in the newborn period and require prompt evaluation to determine the underlying cause for treatment and appropriate sex assignment of the infant. Neonatologists should confer with a multidisciplinary team for the diagnostic evaluation and management of patients with DSDs. This article provides a review of normal sexual development, algorithms used for evaluating infants with ambiguous genitalia, and conditions that can present with ambiguous genitalia in the newborn period.
authors.affiliation: Division of Pediatric Endocrinology, Baylor College of Medicine, Texas Children's Hospital, 6701 Fannin Street, Houston, TX 77030, USA. Electronic address: mccann@bcm.edu.
authors.forename: Bonnie
authors.initials: B
authors.lastname: McCann-Crosby
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Texas Children's Hospital, 6701 Fannin Street, Houston, TX 77030, USA.
authors.forename: V Reid
authors.initials: VR
authors.lastname: Sutton
mesh_terms: D012734:Disorders of Sex Development / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D014943:Global Health; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn
keywords: Ambiguous genitalia; Disorders of sexual development (DSDs); Neonates; Sex assignment