title: Biomarkers for personalized medicine in GI cancers.
abstract: Gastrointestinal malignancies are a major health care challenge due to the high incidence and overall poor outcome. A biomarker is a molecular characteristic of a tumor that may be utilized in the initial risk assessment and the subsequent management of the patient. This review focuses on the most pertinent prognostic and predictive biomarkers used in the clinical management of gastric, pancreas, and colon cancer. The available assays, limitations and clinical use for each biomarker are reviewed. The clinical trials evaluating novel biomarkers in GI cancers are discussed.
authors.affiliation: Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
authors.forename: Shuang Yin
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL, USA.
authors.forename: Shuang Qin
authors.initials: SQ
authors.lastname: Zhang
authors.affiliation: Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
authors.forename: Ganji Purnachandra
authors.initials: GP
authors.lastname: Nagaraju
authors.affiliation: Department of Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA. Electronic address: bassel.el-rayes@emoryhealthcare.org.
authors.forename: Bassel F
authors.initials: BF
authors.lastname: El-Rayes
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D057285:Precision Medicine / Q000379:methods*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarkers; Colorectal cancer; Gastric cancer; Gastrointestinal malignancy; Pancreatic cancer; Personalized medicine