title: Correlation of serum alanine aminotransferase and aspartate aminotransferase with coronary heart disease.
abstract: OBJECTIVE
  This study aimed to explore the relationship between different risk factors (especially serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and coronary heart disease (CHD).
  
  
  METHODS
  A total of 610 inpatients were recruited. Initial coronary angiography (CAG) was performed to evaluate the severity of coronary lesions. On the basis of findings from CAG, patients were divided into control group (n=260) and CHD group (n=350). Logistic regression analysis was employed for the evaluation of clinical characteristics and biochemical parameters, aiming to explore the relationship between risk factors (including AST and ALT) and CHD.
  
  
  RESULTS
  Results showed type 2 diabetes, hypertension, dyslipidemia, smoking and family history of CHD were clinical risk factors of CHD. Laboratory examinations showed the serum levels of triglycerides, low-density lipoprotein, AST and ALT in CHD group were significantly higher than those in control group (P<0.05). Of these parameters, the AST was 50.98±8.12 U/L in CHD group and 20.14±3.94 U/L in control group (P<0.01); the ALT was 42.31±8.34 U/L in CHD group and 18.25±6.38 U/L in control group (P<0.01).
  
  
  CONCLUSIONS
  The serum levels of AST and ALT in CHD patients are higher than those in controls. High serum AST and ALT are biochemical markers which can be used to predict the severity of CHD and are also independent risk factors of CHD.
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ming
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University Shanghai 200072, China.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Xu
keywords: Alanine aminotransferase; aspartate aminotransferase; coronary heart disease; risk