title: The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients.
abstract: OBJECTIVE
  Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT).
  
  
  METHODS
  We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed.
  
  
  RESULTS
  The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group.
  
  
  CONCLUSIONS
  These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Kuo-Shu
authors.initials: KS
authors.lastname: Tang
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Ying-Hsien
authors.identifier: 0000-0002-7127-0046
authors.initials: YH
authors.lastname: Huang
authors.affiliation: Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Chao-Long
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Li-Tung
authors.identifier: 0000-0001-7403-288X
authors.initials: LT
authors.lastname: Huang
authors.affiliation: Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Jiin-Haur
authors.initials: JH
authors.lastname: Chuang
authors.affiliation: Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
authors.forename: Mao-Meng
authors.initials: MM
authors.lastname: Tiao
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001656:Biliary Atresia / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D002374:Catalase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008099:Liver / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D004272:DNA, Mitochondrial; D008315:Malondialdehyde; D002374:Catalase; D005978:Glutathione