title: Clinical Characteristics of Inpatients with Anaphylaxis in China.
abstract: OBJECTIVE
  To analyze the clinical characteristics of inpatients with anaphylaxis and the factors that influenced those characteristics.
  
  
  METHODS
  Using the patient records from 1990 to 2013 from three highly ranked Chinese hospitals, we retrospectively analyzed the characteristics of 108 inpatients with anaphylaxis (not anaphylaxis admitted).
  
  
  RESULTS
  The mean patient age was 42 ± 20 years old and male-to-female ratio was 1 : 1.3. The number of patients with anaphylaxis increased gradually, and cases diagnosed after 2005 accounted for 68.5% of the 108 total cases. The most common trigger was medications. The most common clinical manifestations included cutaneous, nervous, respiratory, circulatory, and digestive signs and symptoms. Male patients were more likely to experience loss of consciousness. Multisystem involvement was more likely to develop in patients with low BP, whereas it was uncommon in those with anaphylaxis induced by antibiotics or anesthetics. Epinephrine was used as the first-line treatment for 56 cases.
  
  
  CONCLUSIONS
  Inpatient with anaphylaxis was more common in female patients and the number increased gradually during the study period. The most common trigger was medications. Patients with low BP were prone to having multisystem involvement, whereas the cases of anaphylaxis induced by antibiotics and anesthetics were less likely to involve multiple organ systems.
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Respiratory Medicine, The General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
authors.forename: Han-Yi
authors.initials: HY
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Ju
authors.identifier: 0000-0001-5126-8777
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Jin-Lu
authors.initials: JL
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, The General Hospital of Chinese People's Liberation Army, Beijing 100853, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Respiratory Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Li
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Diao
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure; D002648:Child; D002675:Child, Preschool; D002681:China; D064420:Drug-Related Side Effects and Adverse Reactions / Q000188:drug therapy* / Q000503:physiopathology; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D004837:Epinephrine