title: Magnetic Resonance Imaging, Digital Mammography, and Sonography: Tumor Characteristics and Tumor Biology in Primary Setting.
abstract: The use of imaging in the arena of primary treatment for breast cancer is gaining importance as a technique for assessing response to chemotherapy as well as assessing the underlying tumor biology. Both mammography and ultrasound have traditionally been used, in addition to clinical evaluation, to evaluate response to treatment although they have shed little light on the underlying biological processes. Functional magnetic resonance imaging techniques have the ability to assess response to treatments in addition to providing valuable information on changes in tumor perfusion, vascular permeability, oxygenation, cellularity, proliferation, and metabolism both at baseline and after treatment. This noninvasive method of evaluating cellular function is of importance both as endpoints for clinical trials and to our understanding of the biological mechanisms of cancer.
authors.affiliation: Academic Oncology Unit (DKW, AM) and Paul Strickland Scanner Centre (ARP), Mount Vernon Cancer Centre, Northwood, UK.
authors.forename: David K
authors.initials: DK
authors.lastname: Woolf
authors.affiliation: Academic Oncology Unit (DKW, AM) and Paul Strickland Scanner Centre (ARP), Mount Vernon Cancer Centre, Northwood, UK.
authors.forename: Anwar R
authors.initials: AR
authors.lastname: Padhani
authors.affiliation: Academic Oncology Unit (DKW, AM) and Paul Strickland Scanner Centre (ARP), Mount Vernon Cancer Centre, Northwood, UK. amakris@nhs.net.
authors.forename: Andreas
authors.initials: A
authors.lastname: Makris
mesh_terms: D001940:Breast / Q000187:drug effects / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods*; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*