title: Two SNPs of ATP-binding cassette B1 gene on the risk and prognosis of colorectal cancer.
abstract: We conducted a case-control study to investigate the role of ABCB1 C3435T and G2677T/A in the susceptibility and prognosis of colorectal cancer patients. A total of 316 patients with colorectal cancer and 316 controls were collected between January 2009 and January 2011. Genotyping of ABCB1 C3435T and G2677T/A was conducted by the methods of Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Conditional logistic regression analysis showed that subjects carrying CT and CC genotypes of ABCB1 C3435T were more frequently observed in colorectal cancer patients when compared with controls, and the adjusted ORs were 1.62 (1.05-2.52) and 2.05 (1.25-3.36), respectively. By Cox regression analysis, we found that the TT genotype of ABCB1 C3435T was significantly associated with shorter PFS and OS in patients with colorectal cancer when compared with CC genotype, with adjusted HR (95% CI) of 2.57 (1.14-6.04) and 2.54 (1.05-6.61), respectively. We found that the ABCB1 C3435T polymorphism could affect the susceptibility and clinical outcome of colorectal cancer patients.
authors.affiliation: Department of General Surgery, Zhujiang Hospital, Southern Medical University Guangzhou, China ; Department of General Surgery, The Affiliated Hospital of Inner Mongolia Medical University Huhhot, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Zonghai
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Zhujiang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Kehong
authors.initials: K
authors.lastname: Zheng
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Inner Mongolia Medical University Huhhot, China.
authors.forename: Haiping
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Inner Mongolia Medical University Huhhot, China.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Hu
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: ATP-binding cassette B1 gene; clinical outcome; colorectal cancer; susceptibility