title: Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.
abstract: Brown and beige adipose tissue is specialized for heat production and can be activated to reduce obesity and metabolic dysfunction in animals. Recent studies also have indicated that human brown fat activity levels correlate with leanness. This has revitalized interest in brown fat biology and has driven the discovery of many new regulators of brown fat development and function. This review summarizes recent advances in our understanding of the transcriptional mechanisms that control brown and beige fat cell development.
authors.affiliation: Institute for Diabetes, Obesity and Metabolism, Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA sealep@upenn.edu.
authors.forename: Patrick
authors.initials: P
authors.lastname: Seale
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D050156:Adipogenesis; D002001:Adipose Tissue, Brown / Q000502:physiology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D051792:Basic Helix-Loop-Helix Proteins / Q000502:physiology; D055419:Bone Morphogenetic Protein 7 / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D047495:PPAR gamma / Q000502:physiology; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012097:Repressor Proteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D000318:Adrenergic beta-Agonists; D051017:Apoptosis Regulatory Proteins; D051792:Basic Helix-Loop-Helix Proteins; D055419:Bone Morphogenetic Protein 7; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D047495:PPAR gamma; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C525819:BMP7 protein, human; C489923:EBF2 protein, human; C115117:KLF11 protein, human; C486497:PPARGC1A protein, human; C416371:PRDM16 protein, human; C000596710:Zfp516 protein, mouse