title: Effect of Shenzhu Guanxin Recipe () on patients with angina pectoris after percutaneous coronary intervention: A prospective, randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of a combination therapy using Chinese medicine (CM) Shenzhu Guanxin Recipe (, SGR) and standard Western medicine treatment (SWMT) in patients with angina pectoris after percutaneous coronary intervention (PCI).
  
  
  METHODS
  Double-blind randomized controlled trial was used in this experimental procedure. One hundred and eighty-seven patients with coronary heart disease receiving SWMT after PCI were randomly assigned to the treatment (SGR) and control (placebo) groups. Outcome measures including angina pectoris score (APS), CM symptom score, and Seattle Angina Questionnaire (SAQ) score were evaluated in 1, 2, 3 and 12 months, and the death rate, restenosis and other emergency treatments were observed. The mixed-effects models were employed for the data analysis.
  
  
  RESULTS
  In the treatment group, a larger within-treatment effect size (d=1.74) was found, with a 76.7% reduction in APS from pretreatment to 12-month follow-up assessment compared with the control group (d=0.83, 53.8% symptom reduction); betweentreatment (BT) effect size was d=0.66. CM symptom scores included an 18.3% reduction in the treatment group (d=0.46), and a 16.1% decrease in the control group (d=0.31); d=0.62 for BT effect size. In regard to scores of SAQ, the BT effect size of cognition level of disease was larger in the treatment group (d=0.63), followed by the level of body limitation of activity (d=0.62), condition of angina pectoris attacks (d=0.55), satisfaction level of treatments (d=0.31), and steady state of angina pectoris (d=0.30). Two cardiovascular related deaths and one incidental death were recorded in the control and treatment groups, respectively. No significant difference in any cardiovascular event (including death toll, frequency of cardiovascular hospitalization or emergency room visits) was found between the two groups.
  
  
  CONCLUSIONS
  The combination therapy of SGR and SWMT is effective and safe in patients with angina pectoris after PCI when compared with SWMT alone.
authors.affiliation: Cardiovascular Department, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, China.
authors.forename: Dan-Ping
authors.initials: DP
authors.lastname: Xu
authors.forename: Huan-Lin
authors.initials: HL
authors.lastname: Wu
authors.forename: Tao-Hua
authors.initials: TH
authors.lastname: Lan
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Sheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Lin
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Chao-Yang
authors.initials: CY
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000601:surgery*; D003710:Demography; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D023381:Endpoint Determination; D005260:Female; D006801:Humans; D008297:Male; D062645:Percutaneous Coronary Intervention; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C000605766:shenzhu guanxin