title: A Very Rare Case -  Hairy Cell Leukemia in Patient with Sarcoidosis.
abstract: Although the coexistence of hairy cell leukemia with sarcoidosis has been reported in a few cases in the literature, in our case the patient had been diagnosed and followed about 10 years with sarcoidosis and massive splenomegaly. It has been demonstrated that T helper 1 cells exist in organs influenced by sarcoidosis. These cells produce IL-2 and IFN-γ and induce a nonspecific inflammatory response and granuloma formation. Also these cytokines may play a role in the development of hairy cell leukemia.Key words: hairy cell leukemia -  sarcoidosis - massive splenomegaly.
authors.forename: N
authors.initials: N
authors.lastname: Karadurmus
authors.forename: G
authors.initials: G
authors.lastname: Erdem
authors.forename: Y
authors.initials: Y
authors.lastname: Basaran
authors.forename: I
authors.initials: I
authors.lastname: Naharci
authors.forename: C
authors.initials: C
authors.lastname: Tasci
authors.forename: T
authors.initials: T
authors.lastname: Dogan
authors.forename: A
authors.initials: A
authors.lastname: Ifran
authors.forename: K
authors.initials: K
authors.lastname: Kaptan
authors.forename: K
authors.initials: K
authors.lastname: Saglam
authors.forename: C
authors.initials: C
authors.lastname: Beyan
mesh_terms: D000368:Aged; D016207:Cytokines; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D012507:Sarcoidosis / Q000150:complications / Q000276:immunology*; D013154:Spleen / Q000276:immunology*
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D007371:Interferon-gamma