title: Efficacy and safety of intravenous nimodipine administration for treatment of hypertension in patients with intracerebral hemorrhage.
abstract: BACKGROUND
  Nicardipine (NC) is the most commonly used antihypertensive drug in neurological patients with hypertension. Although nimodipine (NM) is widely used to treat cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage, trials exploring its antihypertensive effect after intravenous administration in subjects with intracerebral hemorrhage (ICH) are scarce.
  
  
  METHODS
  A retrospective study was carried out to compare the safety and efficacy of NC and NM administered intravenously in patients with ICH. Therapeutic responses were assessed by achievement of goal blood pressure (BP); use of additional medications for BP control; proportion of time spent within goal; variability in BP; time to goal BP; number of dose adjustments; variability in ICH volume, Glasgow Coma Scale score, and intracranial pressure; and drug-related complications.
  
  
  RESULTS
  A total of 87 patients were eligible for analysis (n=46 [NC]; n=41 [NM]), and baseline characteristics between groups were similar. Both agents were effective in achieving goal BP during infusion, with 93.5% and 87.8% patients in the NC and NM groups achieving goal, respectively. Fewer additional medications were needed to control BP in the NC group. BP variability was similar and no differences were observed in the mean time to goal BP and mean numbers of dose adjustments between both groups. Interestingly, intracranial pressure declined (P=0.048) during NC administration but increased (P=0.066) after NM treatment. Finally, the incidences of hematoma expansion, neurological deterioration, and adverse drug events were similar in both groups.
  
  
  CONCLUSIONS
  NM is effective and safe for BP control in patients with ICH.
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.affiliation: Department of Anesthesiology, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Shunnan
authors.initials: S
authors.lastname: Ge
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Department of Emergency, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Boliang
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Li
keywords: blood pressure; intravenous infusion; nicardipine