title: Sodium butyrate protects the intestinal barrier function in peritonitic mice.
abstract: OBJECTIVE
  Peritonitis is a commonly seen disease with high morbidity and mortality. It is prevalently considered that the impaired intestinal barrier during peritonitis is the access point of gut microbes into the blood system, and acts as the engine of the following systemic infection. In our previous study, we found that Sodium Butyrate (NaB) was protective on intestinal barrier function. In this study, we aim to evaluate the effects of NaB on overwhelming infection animal models of peritonitis.
  
  
  METHODS
  Mouse cecal ligation and puncture (CLP) model was used to study the effects of NaB on the intestinal barrier. Experimental animals were fed of NaB by gavage. Post-CLP mortality, gut permeability and intestinal histological alterations were studied.
  
  
  RESULTS
  Gastrointestinal NaB pharmacodynamics profiles after medication were studied. Measurements of NaB concentration in chyme showed significantly higher intestinal concentration of NaB in the NaB treated group than that of the control group. CLP-induced mortality was significantly decreased by oral NaB treatments. Gut permeability was largely increased after CLP, which was partially prevented by NaB feeding. Histological study showed that intestinal, especially ileal injury following peritonitis was substantially alleviated by NaB treatments. Moreover, tissue regeneration was also prompted by NaB.
  
  
  CONCLUSIONS
  NaB has a potential protective effect on intestinal barrier function in peritonitis.
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Han
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Song
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China.
authors.forename: Yunlei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China.
authors.forename: Yingmo
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Beijing Chao-Yang Hospital, Capital Medical University Beijing 100043, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
keywords: Sodium butyrate; intestinal barrier; peritonitis mice