title: CETSA: a target engagement assay with potential to transform drug discovery.
authors.affiliation: Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Tomtebodavägen 23A, 171 65 Solna, Sweden.
authors.forename: Annika Jenmalm
authors.initials: AJ
authors.lastname: Jensen
authors.affiliation: Pelago Bioscience AB, Nobels väg 3, 17165 Solna, Sweden.
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez Molina
authors.affiliation: Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Tomtebodavägen 23A, 171 65 Solna, Sweden.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lundbäck
mesh_terms: D016503:Drug Delivery Systems; D055808:Drug Discovery; D006358:Hot Temperature; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations
keywords: CETSA; R&D efficiency; cellular thermal shift assay; phenotypic-based drug-discovery; target engagement; target-based drug-discovery