title: Plasma fatty acid composition in French-Canadian children with non-alcoholic fatty liver disease: Effect of n-3 PUFA supplementation.
abstract: Non-alcoholic fatty liver disease (NAFLD) represents one of the most common causes of liver disease worldwide. As the NAFLD pathogenesis is associated with diet and lifestyle, the aims of the present work are to assess fatty acid (FA) composition in NAFLD young French-Canadian, to determine whether treatment with n-3 FA improves the plasma FA profile, and to define the time on the effectiveness of n-3 FA supplementation. Baseline characteristics of the NAFLD subjects show increased, anthropometric and biochemical parameters. Their plasma FA composition is characterized by a percent increase in total n-6 FA and a high proportion of saturated and total monounsaturated FA, as well as a decrease in Δ5 and increase in Δ6 desaturases. In conclusion, our results document for the first time the composition of plasma FAs in NAFLD young French Canadian and the efficacy of 3-month supplementation to improve the proportion of n-3 FA in their plasma.
authors.affiliation: Research Centre, CHU Sainte-Justine Montreal, Montreal, Quebec, Canada, H3T 1C5; Department of Nutrition, Université de Montreal, Montreal, Quebec, Canada, H3T 1A8; Institute of Nutraceuticals and Functional foods (INAF), Université Laval, Quebec, Quebec, Canada, G1V 0A6.
authors.forename: S
authors.initials: S
authors.lastname: Spahis
authors.affiliation: Research Centre, CHU Sainte-Justine Montreal, Montreal, Quebec, Canada, H3T 1C5; Department of Pediatrics, Université de Montreal, Montreal, Quebec, Canada, H3T 1C5.
authors.forename: F
authors.initials: F
authors.lastname: Alvarez
authors.affiliation: Research Centre, CHU Sainte-Justine Montreal, Montreal, Quebec, Canada, H3T 1C5; Department of Radiology, Université de Montreal, Montreal, Quebec, Canada, H3T 1C5.
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.affiliation: The Montreal Children's Hospital, McGill University Health Centre, Montreal Quebec, Canada, H3H 1P3.
authors.forename: N
authors.initials: N
authors.lastname: Ahmed
authors.affiliation: Centre de recherche Rhône-Alpes en nutrition humaine, Hôpital Edouard-Herriot, Faculté de Médicine, Université de Lyon-1, France.
authors.forename: N
authors.initials: N
authors.lastname: Peretti
authors.affiliation: Research Centre, CHU Sainte-Justine Montreal, Montreal, Quebec, Canada, H3T 1C5; Department of Nutrition, Université de Montreal, Montreal, Quebec, Canada, H3T 1A8; Institute of Nutraceuticals and Functional foods (INAF), Université Laval, Quebec, Quebec, Canada, G1V 0A6. Electronic address: emile.levy@recherche-ste-Justine.qc.ca.
authors.forename: E
authors.initials: E
authors.lastname: Levy
mesh_terms: D000293:Adolescent; D002648:Child; D019587:Dietary Supplements; D005227:Fatty Acids / Q000097:blood* / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000378:metabolism*; D011792:Quebec
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3
keywords: Fatty acids; NAFLD; Obesity; PUFA; Supplementation; n-3 fatty acids