title: CYP1A1 genetic polymorphisms and uterine leiomyoma risk: a meta-analysis.
abstract: BACKGROUND
  Some studies assessed the association between CYP1A1 MspI and Ile462Val polymorphisms and uterine leiomyoma (UL) risk. However, the results were controversial. We did this meta-analysis to determine the association between CYP1A1 MspI and Ile462Val polymorphisms and UL risk.
  
  
  METHODS
  We searched databases containing PubMed, Springer Link, EMBASE, Chinese National Knowledge Infrastructure (CNKI) up to 11 October 2014. Pooled ORs and 95% CIs were used to assess the strength of the associations.
  
  
  RESULTS
  In total, 9 case-control studies with 2157 UL cases and 2197 healthy controls were included in this meta-analysis. CYP1A1 Ile462Val polymorphism was significantly associated with UL risk (OR = 2.29, 95% CI 1.75-2.99, P < 0.00001). In the subgroup analysis by race, significantly increased risks were found in the Asians (OR = 2.76, 95% CI 1.86-4.09, P < 0.00001) and Caucasians (OR = 1.87, 95% CI 1.30-2.68, P = 0.0007). However, MspI polymorphism was not significantly associated with UL risk (OR = 1.15, 95% CI 0.90-1.47, P = 0.27). In the subgroup analysis by race, no significant association was found in the Asians (OR = 1.15, 95% CI 0.86-1.54, P = 0.35).
  
  
  CONCLUSIONS
  In summary, the results of the meta-analysis suggested that CYP1A1 Ile462Val polymorphism was significantly associated with UL risk.
authors.affiliation: Department of Gynecology, The Peoples' Hospital of Xinjiang Urumqi 830001, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Gynecology, The Peoples' Hospital of Xinjiang Urumqi 830001, China.
authors.forename: Jiying
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Gynecology, The Peoples' Hospital of Xinjiang Urumqi 830001, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gynecology, The Peoples' Hospital of Xinjiang Urumqi 830001, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Gynecology, The Peoples' Hospital of Xinjiang Urumqi 830001, China.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Mayinuer
keywords: CYP1A1; Meta-analysis; polymorphism; uterine leiomyoma