title: Calcium homeostasis disruption - a bridge connecting cadmium-induced apoptosis, autophagy and tumorigenesis.
abstract: Calcium and cadmium are divalent metals and have similar chemical properties. Both can enter cells through, albeit different, channels, or through protein-dependent permeation. However, cadmium disturbs the calcium homeostasis by inhibiting calcium channels and/or related proteins. Cadmium can also alter membrane phospholipid concentrations, and so induce a calcium homeostasis disorder. The altered calcium homeostasis induced by cadmium results in cell apoptosis, autophagy or tumorigenesis. In this review, calcium homeostasis disruption is summarized as a bridge connecting cadmium-induced apoptosis, autophagy, and tumorigenesis.
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, China.
authors.forename: Xuehai
authors.initials: X
authors.lastname: Zhou
authors.forename: Weiming
authors.initials: W
authors.lastname: Hao
authors.forename: Haifeng
authors.initials: H
authors.lastname: Shi
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
authors.forename: Qinggang
authors.initials: Q
authors.lastname: Xu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001343:Autophagy / Q000187:drug effects*; D002104:Cadmium / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism*; D063646:Carcinogenesis / Q000139:chemically induced*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans
chemical_list: D002104:Cadmium; D002118:Calcium