title: Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69.
abstract: Two new meroterpenes, phenylpyropenes E (1) and F (2), together with seven known phenylpyropenes (3-5) and pyripyropenes (6-9) were isolated from the marine-derived fungus Penicillium concentricum ZLQ-69. Their structures including the absolute configurations were elucidated using a combination of spectroscopic methods and electronic circular dichroism calculation. Bioactivity evaluation showed that compounds 1 and 4 were cytotoxic to the MGC-803 cell line with IC50 values of 19.1 and 13.6 μM, respectively.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Lianqing
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Fu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Che
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Dehai
authors.initials: D
authors.lastname: Li
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Qianqun
authors.initials: Q
authors.lastname: Gu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D010407:Penicillium / Q000737:chemistry*; D013057:Spectrum Analysis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D013729:Terpenes; C000606977:phenylpyropene E