title: Immunological Profiling of Obesity.
abstract: It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity. Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity. This immunologic dysregulation has led to the development of the classical pro-inflammatory paradigm. However, since chronic inflammation associated with obesity is more than just the overproduction of pro-inflammatory cytokines, precise dissection requires beyond the classical pro-inflammatory cytokines. The purpose of this review is to summarize the immunological profiling of obesity for theragnostic convenience, focusing on the cytokine and adipokine network in obesity and the significance of the balance of Th1/Th2 immunity.
authors.affiliation: Department of Environmental Medical Biology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Rosa Mistica C
authors.initials: RM
authors.lastname: Ignacio
authors.affiliation: Department of Microbiology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Cheol-Su
authors.initials: CS
authors.lastname: Kim
authors.affiliation: Department of Microbiology, Yonsei University Wonju College of Medicine, Wonju, Korea ; Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Soo-Ki
authors.initials: SK
authors.lastname: Kim
keywords: Adipokine; Cytokine; Immune homeostasis; Immunological profiling; Obesity