title: Blood Pressure Reduction in the Acute Phase of an Ischemic Stroke Does Not Improve Short- or Long-Term Dependency or Mortality: A Meta-Analysis of Current Literature.
abstract: The purpose of this study was to perform a meta-analysis of current literature to determine whether lowering blood pressure (BP) during the acute phase of an ischemic stroke improves short- and long-term outcomes. PubMed, Cochrane, and Embase were searched until September 5, 2014 using combinations of the search terms: blood pressure reduction, reduced blood pressure, lowering blood pressure, ischemic stroke, acute stroke, and intra-cerebral hemorrhage. Inclusion criteria were randomized controlled trial and patients with acute stroke (ischemic or hemorrhagic) treated with an antihypertensive agent or placebo. Outcome measures were change in systolic and diastolic BP (SBP, DBP) after treatment, and short- and long-term dependency and mortality rates. A total of 459 studies were identified, and ultimately 22 studies were included in the meta-analysis. The total number of participants in the treatment groups was 5672 (range, 6-2308), and in the control groups was 5416 (range, 6-2033). In most studies, more than 50% of the participants were males and the mean age was more than 60 years. The mean follow-up time ranged from 5 days to 12 months. As expected, treatment groups had a greater decrease in BP than control groups, and this effect was seen with different classes of antihypertensive drugs. Short-term and long-term dependency rates were similar between treatment and control groups (short-term dependency: pooled odds ratio [OR] = 1.041, 95% confidence interval [CI]: 0.936-1.159, P = 0.457; long-term dependency: pooled OR = 1.013, 95% CI: 0.915-1.120, P = 0.806). Short-term or long-term mortality was similar between the treatment and control groups (short-term mortality: pooled OR = 1.020, 95% CI: 0.749-1.388, P = .902; long-term mortality: pooled OR = 1.039, 95% CI: 0.883-1.222, P = 0.644). Antihypertensive agents effectively reduce BP during the acute phase of an ischemic stroke, but provide no benefit with respect to short- and long-term dependency and mortality.
authors.affiliation: From the Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (RZ, F-DL, SW, J-LP, X-XT, BZ, Q-TZ, QY, X-LS, W-TL, YZ, Y-SL, J-JS, LS, J-RL); and Shanghai 85th Hospital of PLA, Shanghai, China (MZ).
authors.forename: Rong
authors.initials: R
authors.lastname: Zhao
authors.forename: Feng-Di
authors.initials: FD
authors.lastname: Liu
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Peng
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Tao
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.forename: Qi-Ting
authors.initials: QT
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Yao
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Shen
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Liu
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Su
authors.forename: Liang
authors.initials: L
authors.lastname: Shu
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Jian-Ren
authors.initials: JR
authors.lastname: Liu
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications* / Q000401:mortality*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D011379:Prognosis; D020521:Stroke / Q000150:complications* / Q000401:mortality*; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents