title: [Role of metabolic lipases and lipotoxicity in the development of non-alcoholic steatosis and non-alcoholic steatohepatitis].
abstract: Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in developed countries, covering a spectrum of pathological conditions ranging from single steatosis to non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma. Its pathogenesis has been often interpreted by the "double-hit" hypothesis, where the lipid accumulation in the liver is followed by proinflammatory mediators inducing inflammation, hepatocellular injury and fibrosis. Nowadays, a more complex model suggests that free fatty acids and their metabolites could be the true lipotoxic agents that contribute to the development of NAFLD and hepatic insulin resistance, suggesting a central role for metabolic lipases in that process.
authors.affiliation: Grupo de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Departamento de Medicina y Cirugía, Universidad Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, España.
authors.forename: Alba
authors.initials: A
authors.lastname: Berlanga
authors.affiliation: Grupo de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Departamento de Medicina y Cirugía, Universidad Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, España.
authors.forename: Esther
authors.initials: E
authors.lastname: Guiu-Jurado
authors.affiliation: Grupo de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Departamento de Medicina y Cirugía, Universidad Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, España; Servicio de Medicina Interna, Hospital Universitario Joan XXIII, Tarragona, España.
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Porras
authors.affiliation: Grupo de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Departamento de Medicina y Cirugía, Universidad Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, España.
authors.forename: Gemma
authors.initials: G
authors.lastname: Aragonès
authors.affiliation: Grupo de recerca GEMMAIR (AGAUR)-Medicina Aplicada, Departamento de Medicina y Cirugía, Universidad Rovira i Virgili (URV), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, España; Servicio de Medicina Interna, Hospital Universitario Joan XXIII, Tarragona, España. Electronic address: tauguet.hj23.ics@gencat.cat.
authors.forename: Teresa
authors.initials: T
authors.lastname: Auguet
mesh_terms: D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D007333:Insulin Resistance; D008049:Lipase / Q000378:metabolism*; D050356:Lipid Metabolism / Q000502:physiology; D008099:Liver / Q000201:enzymology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000201:enzymology / Q000503:physiopathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000201:enzymology / Q000503:physiopathology*
chemical_list: D005230:Fatty Acids, Nonesterified; D018836:Inflammation Mediators; D008049:Lipase
keywords: Enfermedad del hígado graso no alcohólica; Lipasas metabólicas; Lipotoxicidad; Lipotoxicity, Non-alcoholic fatty liver disease; Metabolic lipases