title: Folate and nutrients involved in the 1-carbon cycle in the pretreatment of patients for colorectal cancer.
abstract: To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in non-treated patients with colorectal adenocarcinoma in a reference center for oncology in southeastern Brazil. In total, 195 new cases with colorectal adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency Questionnaire (FFQ). Blood samples from 161 patients were drawn for the assessment of serum folate. A moderate correlation was found between serum concentrations of folate, folate intake and the dietary folate equivalent (DFE) of synthetic supplements. Mulatto or black male patients with a primary educational level had a higher intake of dietary folate. Of patients obtaining folate from the diet alone or from dietary supplements, 11.00% and 0.10%, respectively, had intake below the recommended level. Of the patients using dietary supplements, 35% to 50% showed high levels of folic acid intake. There was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10% to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate choline intake. The considerable percentage of patients with folate intake above the recommended levels deserves attention because of the harmful effects that this nutrient may have in the presence of established neoplastic lesions.
authors.affiliation: Department of Pelvic Surgery, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo (SP) CEP 01509-010, Brazil. ariana_ferrari@hotmail.com.
authors.forename: Ariana
authors.initials: A
authors.lastname: Ferrari
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil. alinemartins2011@gmail.com.
authors.forename: Aline Martins
authors.initials: AM
authors.lastname: de Carvalho
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil. jsteluti@gmail.com.
authors.forename: Josiane
authors.initials: J
authors.lastname: Steluti
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil. jwliana_at@yahoo.com.br.
authors.forename: Juliana
authors.initials: J
authors.lastname: Teixeira
authors.affiliation: Department of Nutrition, School of Public Health, University of São Paulo, Av. Dr. Arnaldo 715, Consolação, São Paulo (SP) CEP 01246-904, Brazil. dirce.marchioni@gmail.com.
authors.forename: Dirce Maria Lobo
authors.initials: DM
authors.lastname: Marchioni
authors.affiliation: Department of Pelvic Surgery, A.C. Camargo Cancer Center, Rua Professor Antônio Prudente, 211, Liberdade, São Paulo (SP) CEP 01509-010, Brazil. samuel.aguiar.jr@gmail.com.
authors.forename: Samuel
authors.initials: S
authors.lastname: Aguiar
mesh_terms: D000368:Aged; D001938:Brazil; D057486:Carbon Cycle; D002794:Choline / Q000008:administration & dosage / Q000097:blood; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012256:Riboflavin / Q000097:blood; D011795:Surveys and Questionnaires; D014805:Vitamin B 12 / Q000097:blood; D025101:Vitamin B 6 / Q000097:blood
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D025101:Vitamin B 6; D005492:Folic Acid; D002794:Choline; D014805:Vitamin B 12; D012256:Riboflavin
keywords: 1-carbon cycle; colorectal carcinogenesis.; folate