title: Gabarapl1 mediates androgen-regulated autophagy in prostate cancer.
abstract: Autophagy plays an important role in prostate cancer development. It promotes tumor cell survival and was found to be associated with androgen pathway. In the present study, we found that GABA(A) receptor-associated protein like 1 (Gabarapl1), a ubiquitin-like modifier, participates in the regulation of autophagy. Gabarapl1 is transcriptionally regulated by androgen receptor (AR) and has a repressive role in autophagy. Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of autophagy flux. Elevated Gabarapl1 also represses the proliferation of prostate cancer cells. In summary, our study provides evidence to show that Gabarapl1 is a mediator involved in androgen-regulated autophagy process.
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China.
authors.forename: Chong-Wei
authors.initials: CW
authors.lastname: Xie
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China.
authors.forename: You
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China.
authors.forename: Sheng-Lin
authors.initials: SL
authors.lastname: Liu
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China.
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Fang
authors.affiliation: Xinxiang Key Lab of Translational Cancer Research, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan, 453003, China. subing0218@gmail.com.|Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York, Buffalo, NY, 14214, USA. subing0218@gmail.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Su
authors.affiliation: Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China. zhangweispace@yeah.net.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics; D000728:Androgens / Q000235:genetics / Q000378:metabolism*; D001343:Autophagy / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D011944:Receptors, Androgen / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C410798:AR protein, human; D048868:Adaptor Proteins, Signal Transducing; D000728:Androgens; C430503:GABARAPL1 protein, human; D008869:Microtubule-Associated Proteins; D011944:Receptors, Androgen
keywords: Androgen; Autophagy; Gabarapl1; Prostate cancer