title: Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients.
abstract: Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings.
authors.affiliation: Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil ; Intensive Care Unit, Emergency Medicine Discipline, Hospital das Clínicas, University of São Paulo, 05403-010 São Paulo, SP, Brazil ; Intensive Care Unit, Hospital Alemão Oswaldo Cruz, 01323-020 São Paulo, SP, Brazil.
authors.forename: Fernando G
authors.initials: FG
authors.lastname: Zampieri
authors.affiliation: Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Jacob
authors.affiliation: Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
authors.forename: Hermes V
authors.initials: HV
authors.lastname: Barbeiro
authors.affiliation: Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
authors.forename: Fabiano
authors.identifier: 0000-0003-2673-2202
authors.initials: F
authors.lastname: Pinheiro da Silva
authors.affiliation: Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
authors.forename: Heraldo P
authors.initials: HP
authors.lastname: de Souza