title: The Use of Ozurdex (Dexamethasone Intravitreal Implant) During Anterior Segment Surgery in Patients with Chronic Recurrent Uveitis.
abstract: OBJECTIVE
  To describe the outcomes of concurrent Ozurdex implantation during anterior segment surgery in patients with chronic recurrent uveitis.
  
  
  METHODS
  Retrospective chart review. Data recorded from preoperative and 1-, 3-, and 6-month postoperative visits included visual acuity, intraocular pressure (IOP), medications, and clinical examination findings of inflammation.
  
  
  RESULTS
  Twelve patients (12 eyes) with chronic, recurrent noninfectious uveitis undergoing cataract extraction (n=9) or intraocular lens (IOL) explantation (n=3) were included. Mean duration of follow-up after Ozurdex implantation was 12.9 months. There was a significant reduction (n=10, P=0.02) in the average number of inflammation recurrences 6 months before surgery compared to 6 months after surgery with Ozurdex in affected eyes. IOP remained stable in the postoperative period. One patient undergoing anterior chamber IOL (ACIOL) explantation experienced migration of Ozurdex into the anterior chamber resulting in corneal edema that resolved after 1 month.
  
  
  CONCLUSIONS
  Ozurdex safely and effectively controlled postoperative inflammation in eyes with chronic recurrent uveitis when concurrently implanted during anterior segment surgery in our patients. Caution should be exercised in cases of IOL explantation, as Ozurdex use is now contraindicated in eyes with posterior capsule rupture and ACIOLs.
authors.affiliation: 1 Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School-Doctors Office Center , Newark, New Jersey.
authors.forename: Ashwinee P
authors.initials: AP
authors.lastname: Ragam
authors.affiliation: 1 Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School-Doctors Office Center , Newark, New Jersey.
authors.forename: Anton M
authors.initials: AM
authors.lastname: Kolomeyer
authors.affiliation: 1 Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School-Doctors Office Center , Newark, New Jersey.
authors.forename: Natasha V
authors.initials: NV
authors.lastname: Nayak
authors.affiliation: 1 Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School-Doctors Office Center , Newark, New Jersey.|2 Metropolitan Eye Research and Surgery Institute , Palisades Park, New Jersey.
authors.forename: David S
authors.initials: DS
authors.lastname: Chu
mesh_terms: D000328:Adult; D000867:Anterior Chamber / Q000601:surgery*; D002387:Cataract Extraction / Q000379:methods; D002908:Chronic Disease; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D058449:Intravitreal Injections / Q000379:methods*; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone