title: [The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase].
abstract: Novel non-competitive inhibitors of HIV RT were synthesized by alkylation of 6-substituted purines with different 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. The structure-activity relationship within the synthesized compounds was studied.
authors.forename: V V
authors.initials: VV
authors.lastname: Komissarov
authors.forename: V T
authors.initials: VT
authors.lastname: Valuev-Elliston
authors.forename: O N
authors.initials: ON
authors.lastname: Ivanova
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: A M
authors.initials: AM
authors.lastname: Kritzyn
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D011687:Purines; D018894:Reverse Transcriptase Inhibitors; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase