title: Pyridoxine induced rosacea-like dermatitis.
abstract: Rosacea is a common chronic inflammatory cutaneous disease of unknown etiology, characterized by remissions and exacerbations, presenting with centrofacial erythema and telangiectasias. It affects mainly adults around the age of 30 years and classically predominates in females. The pathophysiology of rosacea has not yet been fully understood. Risk factors are positive family history, very light skin phototype, sun exposure and consumption of spicy food or alcohol. Recently, there has been some evidence that some drugs or vitamins could be potential factors that can aggravate rosacea or induce rosacea-like symptoms. In this context, we present a 53-year-old female developing rosacea-like dermatitis due to a fixed combination of isoniazid and pyridoxine, which she was receiving along with rifampicin for the treatment of pulmonary tuberculosis.
authors.forename: Saida
authors.initials: S
authors.lastname: Rezaković
authors.forename: Zrinka Bukvić
authors.initials: ZB
authors.lastname: Mokos
authors.forename: Zrinjka
authors.initials: Z
authors.lastname: Paštar
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects; D008875:Middle Aged; D011718:Pyrazinamide / Q000009:adverse effects; D011736:Pyridoxine / Q000009:adverse effects*; D012293:Rifampin / Q000009:adverse effects; D012393:Rosacea / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy; D014803:Vitamin B Complex / Q000009:adverse effects*
chemical_list: D000995:Antitubercular Agents; D004338:Drug Combinations; C087181:isoniazid, pyrazinamide, rifampin drug combination; D014803:Vitamin B Complex; D011718:Pyrazinamide; D011736:Pyridoxine; D007538:Isoniazid; D012293:Rifampin