title: Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics.
abstract: In the present article, we demonstrate the delivery of anti-cancer drug to the cancer cells using biosynthesized gold and silver nanoparticles (b-AuNP & b-AgNP). The nanoparticles synthesized by using Butea monosperma (BM) leaf extract are thoroughly characterized by various analytical techniques. Both b-AuNP and b-AgNP are stable in biological buffers and biocompatible towards normal endothelial cells (HUVEC, ECV-304) as well as cancer cell lines (B16F10, MCF-7, HNGC2 & A549). Administration of nanoparticle based drug delivery systems (DDSs) using doxorubicin (DOX) [b-Au-500-DOX and b-Ag-750-DOX] shows significant inhibition of cancer cell proliferation (B16F10, MCF-7) compared to pristine drug. Therefore, we strongly believe that biosynthesized nanoparticles will be useful for the development of cancer therapy using nanomedicine approach in near future.
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Patra
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Sudip
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Ayan Kumar
authors.initials: AK
authors.lastname: Barui
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Ganguly
authors.affiliation: Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
authors.forename: Bojja
authors.initials: B
authors.lastname: Sreedhar
authors.affiliation: Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India. Electronic address: crpatra@iict.res.in.
authors.forename: Chitta Ranjan
authors.initials: CR
authors.lastname: Patra
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D031290:Butea; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry* / Q000493:pharmacokinetics; D055772:Green Chemistry Technology; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000378:metabolism; D012834:Silver / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D012834:Silver; D006046:Gold; D004317:Doxorubicin
keywords: Biocompatible; Butea monosperma; Cancer therapy; Drug delivery systems; Gold and silver nanoparticles; Green synthesis