title: Adipose tissue redistribution caused by an early consumption of a high sucrose diet in a rat model.
abstract: BACKGROUND
  Obesity is a major public health problem worldwide. The quantity and site of accumulation of adipose tissue is of great importance for the physiopathology of this disease.
  
  
  OBJECTIVE
  The aim of this study was to assess the effect of a high carbohydrate diet on adipose tissue distribution.
  
  
  METHODS
  Male Wistar rats, control (CONT) and high sucrose diet (HSD; 30% sucrose in their drinking water), were monitored during 24 weeks and total energy and macronutrient intake were estimated by measuring daily average consumption. A bioelectrical impedance procedure was performed at 22 weeks of treatment to assess body compartments and systolic arterial blood pressure was measured. Serum was obtained and retroperitoneal adipose tissue was collected and weighed.
  
  
  RESULTS
  HSD ingested less pellets and beverage, consuming less lipids and proteins than CONT, but the same amount of carbohydrates. Retroperitoneal adipose tissue was more abundant in HSD. Both groups were normoglycemic; triglycerides, adiponectin and leptin levels were higher, while total cholesterol and HDL-cholesterol were lower in HSD; insulin, HOMA index and systolic blood pressure had a tendency of being higher in HSD.
  
  
  CONCLUSIONS
  This model presents dyslipidemia and a strong tendency for insulin resistance and hypertension. Even though there was no difference in body compartments between groups, retroperitoneal adipose tissue was significantly increased in HSD. This suggests that a rearrangement of adipose tissue distribution towards the abdominal cavity takes place as a result of chronic high sucrose consumption, which contributes to a higher risk of suffering from metabolic and chronic degenerative diseases.
authors.affiliation: Laboratory of Nutrigenomics and Nutrigenetics, National Institute of Genomic Medicine. Periférico Sur #4809, Col. Arenal Tepepan, Tlalpan, C.P. 14610.. ash.castellanos@outlook.com.
authors.forename: Ashley Kate
authors.initials: AK
authors.lastname: Castellanos Jankiewicz
authors.affiliation: Laboratory of Nutrigenomics and Nutrigenetics, National Institute of Genomic Medicine. Periférico Sur #4809, Col. Arenal Tepepan, Tlalpan, C.P. 14610. National School of Biological Sciences, National Polytechnic Institute. Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Miguel Hidalgo, C.P. 11340.. sofiam2205@gmail.com.
authors.forename: Sofía Montserrat
authors.initials: SM
authors.lastname: Rodríguez Peredo
authors.affiliation: Department of Endocrinology, National Institute of Cardiology "Ignacio Chávez". Juan Badiano #1, Col. Sección XVI, Tlalpan, C.P. 14080.. gccardosos@yahoo.com.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Cardoso Saldaña
authors.affiliation: Department of Reproductive Biology, National Institute of Medical Sciences and Nutrition "Salvador Zurbirán". Vasco de Quiroga #15, Col. Sección XVI, Tlalpan, C.P. 14080.. eulisesd@yahoo.com.
authors.forename: Eulises
authors.initials: E
authors.lastname: Díaz Díaz
authors.affiliation: Laboratory of Nutrigenomics and Nutrigenetics, National Institute of Genomic Medicine. Periférico Sur #4809, Col. Arenal Tepepan, Tlalpan, C.P. 14610.. etejero@inmegen.gob.mx.
authors.forename: María Elizabeth
authors.initials: ME
authors.lastname: Tejero Barrera
authors.affiliation: Laboratory of Nutrigenomics and Nutrigenetics, National Institute of Genomic Medicine. Periférico Sur #4809, Col. Arenal Tepepan, Tlalpan, C.P. 14610.. ldelbosque@inmegen.gob.mx.
authors.forename: Laura
authors.initials: L
authors.lastname: del Bosque Plata
authors.affiliation: Department of Cardiovascular Biomedicine, National Institute of Cardiology "Ignacio Chávez". Juan Badiano #1, Col. Sección XVI, Tlalpan, C.P. 14080. Mexico D.F.. roxcarbo@gmail.com.
authors.forename: Roxana
authors.initials: R
authors.lastname: Carbó Zabala
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001823:Body Composition; D050218:Body Fat Distribution; D004032:Diet / Q000009:adverse effects*; D004435:Eating; D017097:Electric Impedance; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000009:adverse effects*
chemical_list: D008055:Lipids; D013395:Sucrose