title: A three-component reaction for rapid access to underexplored 1,3-thiazine-2-thiones.
abstract: Driven by the shortage of known effective possibilities for the synthesis of 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones on the one hand and the promising potential of these structures as novel drug candidates on the other hand, synthetic access to 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones was developed. The desired products could be synthesized effectively and facilely starting from β-chlorovinyl aldehydes with the aid of a new MCR (multicomponent reaction). Furthermore, the 4-hydroxy-3,4-dihydro-2H-1,3-thiazine-2-thiones are shown to be appropriate substrates in the preparation of diverse annulated polycyclic systems.
authors.affiliation: Institut für Chemie, Carl von Ossietzky Universität Oldenburg, P. O. Box 2503, Carl-von-Ossietzky-Str. 9-11, 26111 Oldenburg, Germany. fabian.brockmeyer@uni-oldenburg.de.
authors.forename: Denis
authors.initials: D
authors.lastname: Kröger
authors.forename: Fabian
authors.initials: F
authors.lastname: Brockmeyer
authors.forename: Christoph
authors.initials: C
authors.lastname: Kahrs