title: Valsartan.
abstract: Valsartan is an antihypertensive drug which selectively inhibits angiotensin receptor type II. Generally, valsartan is available as film-coated tablets. This review summarizes thermal analysis, spectroscopy characteristics (UV, IR, MS, and NMR), polymorphism forms, impurities, and related compounds of valsartan. The methods of analysis of valsartan in pharmaceutical dosage forms and in biological fluids using spectrophotometer, CE, TLC, and HPLC methods are discussed in details. Both official and nonofficial methods are described. It is recommended to use LC-MS method for analyzing valsartan in complex matrices such as biological fluids and herbal preparations; in this case, MRM is preferred than SIM method.
authors.affiliation: Research & Development, Bernofarm Pharmaceutical Company, Buduran-Sidoarjo, Indonesia.
authors.forename: Febry
authors.initials: F
authors.lastname: Ardiana
authors.affiliation: Faculty of Pharmacy, Airlangga University, Dharmawangsa Dalam, Surabaya, Indonesia.
authors.lastname: Suciati
authors.affiliation: Faculty of Pharmacy, Airlangga University, Dharmawangsa Dalam, Surabaya, Indonesia. Electronic address: gunawanindrayanto@yahoo.com.
authors.forename: Gunawan
authors.initials: G
authors.lastname: Indrayanto
mesh_terms: D047228:Angiotensin II Type 1 Receptor Blockers / Q000737:chemistry*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D006801:Humans; D015394:Molecular Structure; D013678:Technology, Pharmaceutical / Q000379:methods; D013777:Tetrazoles / Q000737:chemistry*; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry; D000068756:Valsartan
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine
keywords: Assay; Bioanalysis; Chromatography; Impurities; Polymorphs; Related compound; Spectroscopy; Valsartan