title: Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature.
abstract: Oxaliplatin is a common chemotherapy drug, used mainly for colon and gastric cancer. Most common side effects are peripheral sensory neuropathy, hematological toxicity, and allergic reactions. A less common side effect is pulmonary toxicity, characterized mainly by interstitial pneumonitis. The incidence of this side effect is unknown, but the toxicity can be fatal. Twenty-six cases of pulmonary toxicity have been described in the literature, seven in the setting of adjuvant treatment. We describe two fatal cases of pulmonary injury related to oxaliplatin and a review of the literature.
authors.affiliation: Division of Oncology, Rambam Health Care Campus, 3109601 Haifa, Israel.
authors.forename: Mor
authors.initials: M
authors.lastname: Moskovitz
authors.affiliation: Division of Oncology, Rambam Health Care Campus, 3109601 Haifa, Israel.
authors.forename: Mira
authors.initials: M
authors.lastname: Wollner
authors.affiliation: Division of Oncology, Rambam Health Care Campus, 3109601 Haifa, Israel.
authors.forename: Nissim
authors.initials: N
authors.lastname: Haim