title: A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin.
abstract: In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at C-4' and C-7 in 2 were selectively protected by chloromethyl methyl ether after the reaction conditions were optimized, then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups.
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. zhangwei20131405@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. dongzexi1215@163.com.
authors.forename: Ze-Xi
authors.initials: ZX
authors.lastname: Dong
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. guting1992@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Gu
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. linianguang@njutcm.edu.cn.
authors.forename: Nian-Guang
authors.initials: NG
authors.lastname: Li
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. zpx20130901@126.com.
authors.forename: Peng-Xuan
authors.initials: PX
authors.lastname: Zhang
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. 15150513147@163.com.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Wu
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. yushaopeng0405@163.com.
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Yu
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. yupingtang@njutcm.edu.cn.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.affiliation: National and Local Collaborative Engineering Center of Chinese Medicinal Resources, Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. jpyang-0828@163.com.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Yang
authors.affiliation: Department of Organic Chemistry, China Pharmaceutical University, Nanjing 211198, China. sszh163@163.com.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Shi
mesh_terms: D047310:Apigenin / Q000737:chemistry*; D001711:Biotransformation; D047309:Flavones / Q000138:chemical synthesis*; D005965:Glucuronates / Q000737:chemistry*; D006801:Humans; D008738:Methyl Ethers / Q000737:chemistry; D008745:Methylation; D012996:Solutions
chemical_list: C000603945:6-O-methylscutellarein; D047309:Flavones; D005965:Glucuronates; D008738:Methyl Ethers; D012996:Solutions; C484876:scutellarin; C073317:chloromethyl methyl ether; D047310:Apigenin; C458179:scutellarein
keywords: 6-O-methylscutellarein; metabolite; scutellarein; scutellarin; synthesis