title: The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects.
abstract: In addition to estrogen dependence, endometriosis is characterized by chronic pelvic inflammation. The impact of the chronic pelvic inflammatory state on other organ systems and women's health is unclear. Endometriosis associated chronic inflammation and potential adverse health effects across the lifespan render it imperative for renewed research vigor into the identification of novel biomarkers of disease and therapeutic options. Herein we propose a number of opportunities for research and development of new therapeutics to address the unmet needs in the treatment of endometriosis per se and its ancillary risks for other diseases in women across the lifespan.
authors.affiliation: Cardiovascular & Metabolic Diseases, Medical Strategy & Science, Quintiles, Inc., 5927 S. Miami Boulevard, Morrisville, NC 27560, USA ; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Hughes
authors.affiliation: Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada L8S 4L8.
authors.forename: W G
authors.initials: WG
authors.lastname: Foster
authors.affiliation: Department of Reproductive Medicine, University of California-San Diego, San Diego, CA 92093-0633, USA.
authors.forename: S K
authors.identifier: 0000-0002-8046-9807
authors.initials: SK
authors.lastname: Agarwal
mesh_terms: D004715:Endometriosis / Q000150:complications / Q000503:physiopathology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D017699:Pelvic Pain / Q000150:complications / Q000503:physiopathology*; D011788:Quality of Life; D016387:Women's Health
chemical_list: D004967:Estrogens