title: National Trends and In-hospital Complication Rates in More Than 1600 Hemispherectomies From 1988 to 2010: A Nationwide Inpatient Sample Study.
abstract: BACKGROUND
  Anatomic and functional hemispherectomies are relatively infrequent and technically challenging. The literature is limited by small samples and single institution data.
  
  
  OBJECTIVE
  We used the Nationwide Inpatient Sample (NIS) database to report on a large population of hemispherectomy patients and their in-hospital complication rates over a 23-year period.
  
  
  METHODS
  Between 1988 and 2010, we identified 304 pediatric hospitalizations in the NIS database where hemispherectomy was performed. Using the NIS weighting scheme, this inferred an estimated 1611 hospitalizations nationwide during this time period. Descriptive statistics were calculated on this inferred sample for patient and hospital characteristics and stratified by the presence of in-hospital complications. The adjusted odds of in-hospital complications and nonroutine discharge were estimated using multivariable models.
  
  
  RESULTS
  The mean age of the patients was 5.9 years; 46% were female, and 54% were white. In the inferred series, 909 hospitalizations (56%) encountered at least 1 in-hospital complication; 42% were surgery related, and 25% were related to the hospitalization itself. For every 1-year increase in age, there was a corresponding 8% increase in the odds of a nonroutine discharge, adjusting for other potential confounders (95% confidence interval: 1.01-1.16). The most common in-hospital complication was the need for a blood transfusion (30%), followed by meningitis (10%), hydrocephalus (8%), postoperative hematoma/stroke (8%), and adverse pulmonary event (8%). Thirty-three mortalities (2%) were inferred from this series.
  
  
  CONCLUSIONS
  This is the largest study to date examining hemispherectomy and associated in-hospital complication rates. This study supports early surgery in patients with medically intractable epilepsy and severe hemispheric disease.
authors.affiliation: *Department of Neurosurgery, University of California Irvine Medical Center, Orange, California; ‡Department of Biostatistics, Flatiron Health, New York, New York; §Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio; ¶Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio; ‖Geisinger Northeast and Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania; #Department of Neurology, Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Sumeet
authors.initials: S
authors.lastname: Vadera
authors.forename: Sandra D
authors.initials: SD
authors.lastname: Griffith
authors.forename: Benjamin P
authors.initials: BP
authors.lastname: Rosenbaum
authors.forename: Andreea
authors.initials: A
authors.lastname: Seicean
authors.forename: Varun R
authors.initials: VR
authors.lastname: Kshettry
authors.forename: Michael L
authors.initials: ML
authors.lastname: Kelly
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Weil
authors.forename: William
authors.initials: W
authors.lastname: Bingaman
authors.forename: Lara
authors.initials: L
authors.lastname: Jehi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D000069279:Drug Resistant Epilepsy / Q000601:surgery; D005260:Female; D038421:Hemispherectomy / Q000009:adverse effects* / Q000401:mortality / Q000639:trends*; D006760:Hospitalization / Q000706:statistics & numerical data; D006776:Hospitals, Pediatric; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D010351:Patient Discharge / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012959:Socioeconomic Factors; D014481:United States / Q000453:epidemiology