title: Phthalimide-Conjugated Ligands Promote Selective Protein Destabilization.
abstract: Phthalimide conjugates induce destabilization of target proteins such as BRD4 in vitro and in vivo.
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D001381:Azepines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018797:Cell Cycle Proteins; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics; D008024:Ligands; D009687:Nuclear Proteins / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D010797:Phthalimides / Q000737:chemistry*; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D044767:Ubiquitin-Protein Ligases; D000092468:Bromodomain Containing Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001381:Azepines; D018797:Cell Cycle Proteins; D008024:Ligands; D009687:Nuclear Proteins; D010447:Peptide Hydrolases; D010797:Phthalimides; D046988:Proteasome Endopeptidase Complex; D014157:Transcription Factors; D014230:Triazoles; D044767:Ubiquitin-Protein Ligases; C561695:(+)-JQ1 compound; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C502543:CRBN protein, human; C037432:phthalimidine