title: Natural killer cell immunosenescence in acute myeloid leukaemia patients: new targets for immunotherapeutic strategies?
abstract: Several age-associated changes in natural killer (NK) cell phenotype have been reported that contribute to the defective NK cell response observed in elderly patients. A remodelling of the NK cell compartment occurs in the elderly with a reduction in the output of immature CD56(bright) cells and an accumulation of highly differentiated CD56(dim) NK cells. Acute myeloid leukaemia (AML) is generally a disease of older adults. NK cells in AML patients show diminished expression of several activating receptors that contribute to impaired NK cell function and, in consequence, to AML blast escape from NK cell immunosurveillance. In AML patients, phenotypic changes in NK cells have been correlated with disease progression and survival. NK cell-based immunotherapy has emerged as a possibility for the treatment of AML patients. The understanding of age-associated alterations in NK cells is therefore necessary to define adequate therapeutic strategies in older AML patients.
authors.affiliation: Immunology Unit, University of Extremadura, Cáceres, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Sanchez-Correa
authors.affiliation: Department of Immunology, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Avenida Menendez Pidal s/n, 14004, Córdoba, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Campos
authors.affiliation: Department of Immunology, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Avenida Menendez Pidal s/n, 14004, Córdoba, Spain.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Pera
authors.affiliation: Department of Hematology, Hospital San Pedro de Alcantara, Cáceres, Spain.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Bergua
authors.affiliation: Department of Hematology, Hospital San Pedro de Alcantara, Cáceres, Spain.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Arcos
authors.affiliation: Department of Hematology, Hospital San Pedro de Alcantara, Cáceres, Spain.
authors.forename: Helena
authors.initials: H
authors.lastname: Bañas
authors.affiliation: Immunology Unit, University of Extremadura, Cáceres, Spain.|Stem Cell Therapy Unit, Minimally Invasive Surgery Centre Jesus Uson, Cáceres, Spain.
authors.forename: Javier G
authors.initials: JG
authors.lastname: Casado
authors.affiliation: Immunology Unit, University of Extremadura, Cáceres, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Morgado
authors.affiliation: Histology and Pathology Unit, Faculty of Veterinary, University of Extremadura, Cáceres, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Duran
authors.affiliation: Department of Immunology, IMIBIC, Reina Sofia University Hospital, University of Cordoba, Avenida Menendez Pidal s/n, 14004, Córdoba, Spain. rsolana@uco.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
authors.affiliation: Immunology Unit, University of Extremadura, Cáceres, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Tarazona
mesh_terms: D000208:Acute Disease; D000368:Aged; D000375:Aging / Q000276:immunology*; D019002:CD56 Antigen / Q000276:immunology / Q000378:metabolism; D006801:Humans; D000068884:Immunosenescence; D016219:Immunotherapy, Adoptive / Q000379:methods; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D007951:Leukemia, Myeloid / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D018448:Models, Immunological
chemical_list: D019002:CD56 Antigen
keywords: AML; Ageing; DNAM-1; NK cells; NKp30; NKp46