title: Mitochondria-Targeted Protective Compounds in Parkinson's and Alzheimer's Diseases.
abstract: Mitochondria are cytoplasmic organelles that regulate both metabolic and apoptotic signaling pathways; their most highlighted functions include cellular energy generation in the form of adenosine triphosphate (ATP), regulation of cellular calcium homeostasis, balance between ROS production and detoxification, mediation of apoptosis cell death, and synthesis and metabolism of various key molecules. Consistent evidence suggests that mitochondrial failure is associated with early events in the pathogenesis of ageing-related neurodegenerative disorders including Parkinson's disease and Alzheimer's disease. Mitochondria-targeted protective compounds that prevent or minimize mitochondrial dysfunction constitute potential therapeutic strategies in the prevention and treatment of these central nervous system diseases. This paper provides an overview of the involvement of mitochondrial dysfunction in Parkinson's and Alzheimer's diseases, with particular attention to in vitro and in vivo studies on promising endogenous and exogenous mitochondria-targeted protective compounds.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, 28040 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernández-Moriano
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, 28040 Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: González-Burgos
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University Complutense of Madrid, 28040 Madrid, Spain.
authors.forename: M Pilar
authors.initials: MP
authors.lastname: Gómez-Serranillos
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D020011:Protective Agents