title: Hypercholesterolemia and Hypertension: Two Sides of the Same Coin.
abstract: The aim of this review article is to summarize the current knowledge about mechanisms that connect blood pressure regulation and hypercholesterolemia, the mutual interaction between hypertension and hypercholesterolemia, and their influence on atherosclerosis development. Our research shows that at least one-third of the population of Western Europe has hypertension and hypercholesterolemia. Several biohumoral mechanisms could explain the relationship between hypertension and hypercholesterolemia and the association between these risk factors and accelerated atherosclerosis. The most investigated mechanisms are the renin-angiotensin-aldosterone system, oxidative stress, endothelial dysfunction, and increased production of endothelin-1. Arterial hypertension is frequently observed in combination with hypercholesterolemia, and this is related to accelerated atherosclerosis. Understanding the mechanisms behind this relationship could help explain the benefits of therapy that simultaneously reduce blood pressure and cholesterol levels.
authors.affiliation: Clinic for Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.|Medical School of Belgrade, University of Belgrade, Belgrade, Serbia.
authors.forename: Branislava
authors.initials: B
authors.lastname: Ivanovic
authors.affiliation: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic", Belgrade, Serbia. marijana_tadic@hotmail.com.
authors.forename: Marijana
authors.initials: M
authors.lastname: Tadic
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D050197:Atherosclerosis / Q000453:epidemiology / Q000503:physiopathology; D001794:Blood Pressure; D019332:Endothelin-1 / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000378:metabolism; D008055:Lipids / Q000097:blood; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D019332:Endothelin-1; D000960:Hypolipidemic Agents; D018836:Inflammation Mediators; D008055:Lipids