title: Fractional Microneedling Radiofrequency Treatment for Acne-related Post-inflammatory Erythema.
abstract: Post-inflammatory erythema is a common result of acne inflammation and is cosmetically unacceptable without effective treatment. Fractional microneedling radiofrequency (FMR) has potential for treatment of post-inflammatory erythema. The aim of this study was to evaluate the efficacy and safety of this treatment. A retrospective chart review was undertaken of 25 patients treated with 2 sessions of radiofrequency at 4-week intervals and 27 patients treated with oral antibiotics and/or topical agents. Efficacy was assessed through an investigator's global assessment of photographs, and the analysis of erythema with image analysis software and photometric devices. Histological changes resulting from the treatment were evaluated by skin biopsy. FMR treatment resulted in significant improvements in erythema with no severe adverse effects. Histological study revealed a reduction in vascular markers and inflammation. FMR is a safe and effective treatment for post-inflammatory erythema, with potential anti-inflammatory and anti-angiogenetic properties.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul 110-744, Korea.
authors.forename: Seonguk
authors.initials: S
authors.lastname: Min
authors.forename: Seon Yong
authors.initials: SY
authors.lastname: Park
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Yoon
authors.forename: Hyuck Hoon
authors.initials: HH
authors.lastname: Kwon
authors.forename: Dae Hun
authors.initials: DH
authors.lastname: Suh
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000175:diagnosis; D001706:Biopsy; D004867:Equipment Design; D004890:Erythema / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018836:Inflammation Mediators / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D009339:Needles; D017060:Patient Satisfaction; D061208:Pulsed Radiofrequency Treatment / Q000295:instrumentation / Q000379:methods*; D011846:Radio Waves; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D055815:Young Adult
chemical_list: C508606:CXCL8 protein, human; D018836:Inflammation Mediators; D016209:Interleukin-8; D016328:NF-kappa B; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A