title: [Relation between structure and function, of the cerebral artery "carotid" in laboratory rat submitted to atherogenic diet].
abstract: OBJECTIVE
  The aim of our investigation was the study of the pathophysiology of the carotid artery in cases of nutritional stress in male atheroresistant Wistar rats.
  
  
  METHODS
  Were administered daily by gavage to experimental rats a high fat diet consisting of peanut oil, cholesterol (3%) and sodium cholate (1%). Throughout this experiment, we conducted monitoring of some biochemical parameters and the morpho-histopathology of the carotid cerebral artery. The results obtained are compared to those of control rats in the same experimental conditions.
  
  
  RESULTS
  We found that this fat diet resulted in experimental rats disruption of biochemical tests and tissular and cellular alterations in carotid wall. Indeed, the biochemical examination shows a significant increase of the parameters studied. Morphological examination revealed thickening of the carotid wall and histopathological examination of this artery, highlights the installation of a vascular remodeling from thickening of the intima-media to the installation of a probable atherosclerosis accompanied by a possible hyalinization and a net fibrosis.
  
  
  CONCLUSIONS
  At the end of this study, although notes that our fat diet could cause a metabolic disorder that can cause multiple tissue and cell damage observed in cerebral artery "carotid" of atheroresistant rats.
authors.affiliation: École nationale supérieur vétérinaire, BP 161 Hacène Badi, E L Harrach, Alger, Algérie; Laboratoire de biologie, physiologie animale et signalisation cellulaire, École normale supérieure Kouba, BP 92 Kouba, 1600 Alger, Algérie. Electronic address: ainouzlynda@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Ainouz
authors.affiliation: Laboratoire de biologie, physiologie animale et signalisation cellulaire, École normale supérieure Kouba, BP 92 Kouba, 1600 Alger, Algérie.
authors.forename: A
authors.initials: A
authors.lastname: Baz
authors.affiliation: Laboratoire de biologie, physiologie animale et signalisation cellulaire, École normale supérieure Kouba, BP 92 Kouba, 1600 Alger, Algérie.
authors.forename: M A
authors.initials: MA
authors.lastname: Ammar Aouchiche
authors.affiliation: École nationale supérieur vétérinaire, BP 161 Hacène Badi, E L Harrach, Alger, Algérie; Laboratoire de biologie, physiologie animale et signalisation cellulaire, École normale supérieure Kouba, BP 92 Kouba, 1600 Alger, Algérie.
authors.forename: M
authors.initials: M
authors.lastname: Zaouani
authors.affiliation: Faculté des sciences biologiques, université des sciences et technologie, Houari Boumedienne, USTHB, BP 32 El Alia, Bab Ezzouar, 16111 Alger, Algérie.
authors.forename: S
authors.initials: S
authors.lastname: Aouichat-Bouguera
authors.affiliation: UMR Qualisud, faculté de pharmacie, université de Montpellier 1, 34093 Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Giaimis
authors.affiliation: Faculté des sciences biologiques, université des sciences et technologie, Houari Boumedienne, USTHB, BP 32 El Alia, Bab Ezzouar, 16111 Alger, Algérie.
authors.forename: N
authors.initials: N
authors.lastname: Omari
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000473:pathology* / Q000503:physiopathology*; D004036:Diet, Atherogenic; D008297:Male; D051381:Rats; D017208:Rats, Wistar
keywords: Atherosclerosis; Athérosclérose; Carotid; Carotide; Cholesterol; Cholestérol; Endothélium vasculaire; High fat diet; Nutritional stress; Régime hyperlipidique; Stress nutritionnel; Vascular endothelium