title: Mycobacterium tuberculosis Meets the Cytosol: The Role of cGAS in Anti-mycobacterial Immunity.
abstract: The intracellular fate of Mycobacterium tuberculosis is a subject of long debate. In this issue of Cell Host & Microbe, three independent studies reveal the detection of cytosolic mycobacterial DNA by the nucleotidyltransferase cGAS, emphasizing the concept of cytosolic access by M. tuberculosis and its role in balancing immune-protection and immune-pathogenesis.
authors.affiliation: Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France.
authors.forename: Laleh
authors.initials: L
authors.lastname: Majlessi
authors.affiliation: Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Institut Pasteur, 25 rue du Dr. Roux, Paris 75015, France. Electronic address: roland.brosch@pasteur.fr.
authors.forename: Roland
authors.initials: R
authors.lastname: Brosch
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D004269:DNA, Bacterial / Q000378:metabolism*; D005260:Female; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007370:Interferon Type I / Q000378:metabolism*; D008297:Male; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000472:pathogenicity*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D014376:Tuberculosis / Q000382:microbiology*; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D058847:Inflammasomes; D007370:Interferon Type I; D009713:Nucleotidyltransferases; C093276:ESAT-6 protein, Mycobacterium tuberculosis; C578390:cGAS protein, human; D000099235:Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase; C578391:cGAS protein, mouse