title: Chemoenzymatic one-pot synthesis in an aqueous medium: combination of metal-catalysed allylic alcohol isomerisation-asymmetric bioamination.
abstract: The ruthenium-catalysed isomerisation of allylic alcohols was coupled, for the first time, with asymmetric bioamination in a one-pot process in an aqueous medium. In the cases involving prochiral ketones, the ω-TA exhibited excellent enantioselectivity, identical to that observed in the single step. As a result, amines were obtained from allylic alcohols with high overall yields and excellent enantiomeric excesses.
authors.affiliation: EntreChem SL, Edificio Científico Tecnológico, Campus El Cristo, 33006 Oviedo, Spain. jgsabin@entrechem.com.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Ríos-Lombardía
authors.forename: Cristian
authors.initials: C
authors.lastname: Vidal
authors.forename: María
authors.initials: M
authors.lastname: Cocina
authors.forename: Francisco
authors.initials: F
authors.lastname: Morís
authors.forename: Joaquín
authors.initials: J
authors.lastname: García-Álvarez
authors.forename: Javier
authors.initials: J
authors.lastname: González-Sabín
mesh_terms: D000586:Amination; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D007659:Ketones; D020005:Propanols; D014867:Water; C006463:allyl alcohol; D012428:Ruthenium