title: Open access target validation is a more efficient way to accelerate drug discovery.
abstract: There is a scarcity of novel treatments to address many unmet medical needs. Industry and academia are finally coming to terms with the fact that the prevalent models and incentives for innovation in early stage drug discovery are failing to promote progress quickly enough. Here we will examine how an open model of precompetitive public-private research partnership is enabling efficient derisking and acceleration in the early stages of drug discovery, whilst also widening the range of communities participating in the process, such as patient and disease foundations.
authors.affiliation: Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Wen Hwa
authors.initials: WH
authors.lastname: Lee
mesh_terms: D035843:Biomedical Research; D004059:Diffusion of Innovation; D055808:Drug Discovery; D033181:Information Dissemination; D056687:Off-Label Use