title: BRAF V600E mutations: a series of case reports in patients with non-small cell lung cancer.
abstract: We present a series of five patients with BRAF-mutated non-small cell lung cancer (NSCLC) from the Moffitt Cancer Center and a brief literature review. Information utilized included outside medical records, imaging studies, pathology reports in which simultaneous mutation testing was performed, and clinic visit notes. In addition, we conducted a literature search of background information using the following search terms: "BRAF mutations", "non-small cell lung cancer", and "driver mutations". Several retrospective studies on BRAF mutations in patients with NSCLC found that the majority of these mutations occur in adenocarcinomas and are V600E mutations. From our patients and literature search, we found that BRAF-V600E mutations occur predominantly in female smokers with adenocarcinomas.
authors.affiliation: Department of Internal Medicine, University of South Florida, Tampa, FL, USA.
authors.forename: Jamie M
authors.initials: JM
authors.lastname: Goldman
authors.affiliation: Department of Thoracic Oncology, Moffitt Cancer Center, Tampa, FL, USA. Electronic address: jhanelle.gray@moffitt.org.
authors.forename: Jhanelle E
authors.initials: JE
authors.lastname: Gray
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF; V600E; adenocarcinoma; driver mutations; non-small cell lung cancer