title: MiRNA-based therapeutic intervention of cancer.
abstract: MicroRNAs (miRNAs) are important modulators of eukaryotic gene expression. By targeting protein coding transcripts, miRNAs influence the cellular transcriptome and proteome, thus helping to determine cell fate. MiRNAs have emerged as crucial molecules in cancer research, in which recent studies have linked erratic expression of miRNAs to carcinogenesis and have provided solid evidence for their potential in cancer therapy. This review briefly summarises the recent knowledge on the involvement of miRNAs in tumourigenesis and reviews current studies on the therapeutic strategies and advances in the delivery of miRNAs.
authors.affiliation: Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Srivatsava.Naidu@cruk.manchester.ac.uk.
authors.forename: Srivatsava
authors.initials: S
authors.lastname: Naidu
authors.affiliation: Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. Peter.Magee@cruk.manchester.ac.uk.
authors.forename: Peter
authors.initials: P
authors.lastname: Magee
authors.affiliation: Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. michela.garofalo@cruk.manchester.ac.uk.
authors.forename: Michela
authors.initials: M
authors.lastname: Garofalo
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*
chemical_list: D035683:MicroRNAs