title: Association between Fas/FasL polymorphism and susceptibility to leukemia: a meta-analysis.
abstract: The polymorphisms in Fas/FasL system were proposed to be associated with susceptibility to leukemia, but recent studies reported controversial findings. Hence, we performed a meta-analysis to assess the association between Fas gene polymorphisms and susceptibility to leukemia. We carried out a literature search in PubMed, Embase, Web of Science and CNKI databases for studies on the associations between Fas/FasL gene polymorphisms and susceptibility to leukemia. The associations were assessed by odds ratio (OR) together with its 95% confidence intervals (CIs). 7 literatures and 14 studies with a total of 8787 subjects were eventually included into our meta-analysis. Overall, there was no association between Fas/FasL polymorphisms and susceptibility to leukemia. In subgroup analysis by ethnicity, there was also no association between Fas/FasL polymorphisms and susceptibility to leukemia in Asians and Caucasians. In addition, there was also a significant association between Fas-1377G/A polymorphism and susceptibility to leukemia in ALL patients, the A allele seemed to be a protective factor in ALL risk. In summary, more studies with large sample size are needed to provide further evidence for association between Fas/FasL polymorphisms and susceptibility to leukemia.
authors.affiliation: Second School of Clinical Medicine, Southern Medical University Guangzhou 510515, China.
authors.forename: Yiran
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Second School of Clinical Medicine, Southern Medical University Guangzhou 510515, China.
authors.forename: Yiho
authors.initials: Y
authors.lastname: He
authors.affiliation: Second School of Clinical Medicine, Southern Medical University Guangzhou 510515, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Lu
authors.affiliation: Second School of Clinical Medicine, Southern Medical University Guangzhou 510515, China.
authors.forename: Zhirui
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Second School of Clinical Medicine, Southern Medical University Guangzhou 510515, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University Guangzhou 510282, China.
authors.forename: Tongyuan
authors.initials: T
authors.lastname: Xue
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University Guangzhou 510282, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Li
keywords: Leukemia; meta-analysis; polymorphism