title: Vaccines for preventing invasive salmonella infections in people with sickle cell disease.
abstract: BACKGROUND
  Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This is an update of a previously published Cochrane Review.
  
  
  OBJECTIVE
  To determine whether routine administration of salmonella vaccines to people with sickle cell disease reduces the morbidity and mortality associated with infection.
  
  
  METHODS
  We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.We also conducted a search of the LILACS database.Date of most recent searches: 05 May 2015.
  
  
  METHODS
  We planned to select all randomized controlled trials that compared the use of either the inactivated vaccine or an oral attenuated vaccine with a placebo among people with sickle cell disease. Equally, studies that compared the efficacy of one vaccine type over another were to be selected for the review.
  
  
  METHODS
  No trials of salmonella vaccines in people with sickle cell disease were found.
  
  
  RESULTS
  There is an absence of randomized controlled trial evidence relating to the scope of this review.
  
  
  CONCLUSIONS
  It is expected that salmonella vaccines may be useful in people with sickle cell disease, especially in resource-poor settings where the majority of those who suffer from the condition are found. Unfortunately, there are no randomized controlled trials on the efficacy and safety of the different types of salmonella vaccines in people with sickle cell disease. We conclude that there is a need for a well-designed, adequately-powered, randomized controlled trial to assess the benefits and risks of the different types of salmonella vaccines as a means of improving survival and decreasing mortality from salmonella infections in people with sickle cell disease.
authors.affiliation: Department of Paediatrics, University of Calabar Teaching Hospital, PMB 1115, Calabar, Cross River State, Nigeria, 540261.
authors.forename: Friday
authors.initials: F
authors.lastname: Odey
authors.forename: Uduak
authors.initials: U
authors.lastname: Okomo
authors.forename: Angela
authors.initials: A
authors.lastname: Oyo-Ita
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D006801:Humans; D012480:Salmonella Infections / Q000517:prevention & control*; D022562:Salmonella Vaccines / Q000008:administration & dosage*
chemical_list: D022562:Salmonella Vaccines