title: MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9.
abstract: Increasing studies have shown that MicroRNAs (miRNAs) play critical roles in the progression of lung carcinoma. In the present study, the expression and functions of miR-570 were investigated. We found that miR-570 was significantly up-regulated in lung cancer tissues, compared with adjacent non-cancerous tissues. In vitro studies further showed that miR-570 mimics could promote, while its antisense oligos inhibit cell proliferation and invasion. At the molecular level, krüppel-like factor 9 (KLF9), a tumor suppressor gene, was identified as a potential target of miR-570 in lung cancer cells. Indeed, miR-570 could negatively regulate protein levels of KLF9 through targeting its 3'-untranslated region. Taken together, our results suggest a previously unknown miR-570/KLF9 molecular network controlling lung carcinoma progression.
authors.affiliation: Department of Thoracic Surgery, General Hospital of Shenyang Military Area Command No. 83 Wenhua Road, Shenhe District, Shenyang 110840, China.
authors.forename: Xiang-Dong
authors.initials: XD
authors.lastname: Tong
authors.affiliation: Department of Thoracic Surgery, General Hospital of Shenyang Military Area Command No. 83 Wenhua Road, Shenhe District, Shenyang 110840, China.
authors.forename: Tie-Qin
authors.initials: TQ
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, First Hospital, China Medical University 155 Nanjing Beijie, Shenyang 110001, China.
authors.forename: Ge-Bang
authors.initials: GB
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, First Hospital, China Medical University 155 Nanjing Beijie, Shenyang 110001, China.
authors.forename: Chen-Lei
authors.initials: CL
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Surgery, General Hospital of Shenyang Military Area Command No. 83 Wenhua Road, Shenhe District, Shenyang 110840, China.
authors.forename: Hong-Xu
authors.initials: HX
authors.lastname: Liu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism*; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection; D015854:Up-Regulation
chemical_list: C489676:KLF9 protein, human; D051741:Kruppel-Like Transcription Factors; C582115:MIRN570 microRNA, human; D035683:MicroRNAs; D016376:Oligonucleotides, Antisense
keywords: KLF9; Lung carcinoma; MicroRNA; miR-570