title: Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation.
abstract: The transcription-regulating activity of TFEB is dependent on its phosphorylation modification, but the phosphatase(s) involved in TFEB dephosphorylation have remained elusive. It has now become clear that lysosomal calcium signaling activates calcineurin, an endogenous serine/threonine phosphatase, which dephosphorylate TFEB leading to upregulation of autophagy.
authors.affiliation: a Department of Toxicology; School of Public Health; Shandong University ; Jinan , Shandong , China.
authors.forename: Yanju
authors.initials: Y
authors.lastname: Tong
authors.forename: Fuyong
authors.initials: F
authors.lastname: Song
mesh_terms: D000818:Animals; D001343:Autophagy / Q000235:genetics*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D019703:Calcineurin / Q000235:genetics*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D050051:Transient Receptor Potential Channels / Q000235:genetics*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D050051:Transient Receptor Potential Channels; D019703:Calcineurin
keywords: calcineurin; calcium signaling; transcription factor EB