title: Association of Antegrade Pulmonary Artery Diastolic Velocity with Spontaneous Closure of the Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants.
abstract: OBJECTIVE
  This study aims to determine echocardiographic parameters associated with spontaneous patent ductus arteriosus (PDA) closure in extremely low-birth-weight (ELBW) infants.
  
  
  METHODS
  Retrospective demographic review and analysis of echocardiograms from 189 ELBW infants with suspected and confirmed hemodynamically significant PDA identified on an initial echocardiogram was performed. Comparison of echocardiographic parameters was made between infants with spontaneous closure versus those who received treatment.
  
  
  RESULTS
  The mean birth weight (787 ± 142 vs. 724 ± 141 g, p = 0.04) and gestational age (27.4 ± 2.8 vs. 26.2 ± 1.6 weeks, p = 0.03) were higher in the spontaneous closure versus the treatment group. Antegrade pulmonary artery (PA) diastolic velocity was lower in infants with spontaneous PDA closure versus those who received treatment (0.15 ± 0.06 vs. 0.22 ± 0.12 m/s, p = 0.009).
  
  
  CONCLUSIONS
  Heavier and more mature ELBW infants with a lower antegrade PA diastolic velocity were likely to have spontaneous closure of the PDA.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Weiss
authors.affiliation: Division of Neonatology, Departments of Pediatrics and Obstetrics and Gynecology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Kaiser
authors.affiliation: Division of Biostatistics, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Christopher
authors.initials: C
authors.lastname: Swearingen
authors.affiliation: Division of Cardiology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
authors.forename: Sadia
authors.initials: S
authors.lastname: Malik
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Emory School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Ritu
authors.initials: R
authors.lastname: Sachdeva
mesh_terms: D001783:Blood Flow Velocity; D006348:Cardiac Surgical Procedures; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D003971:Diastole; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D004452:Echocardiography; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D008026:Ligation; D008297:Male; D011379:Prognosis; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012075:Remission, Spontaneous; D012189:Retrospective Studies
chemical_list: D016861:Cyclooxygenase Inhibitors