title: Lessons learned from the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT).
abstract: Cardiac resynchronization therapy (CRT) has evolved as a Class I treatment indication with Level of Evidence A, in patients with mild heart failure, depressed left ventricular ejection fraction, and wide QRS. In this review article, we will discuss the major findings of sub-studies published from the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT).
authors.affiliation: Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY. Electronic address: Valentina.Kutyifa@heart.rochester.edu.
authors.forename: Valentina
authors.initials: V
authors.lastname: Kutyifa
authors.affiliation: Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY.
authors.forename: Ilan
authors.initials: I
authors.lastname: Goldenberg
authors.affiliation: Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, NY.
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Moss
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000009:adverse effects / Q000379:methods; D002986:Clinical Trials as Topic; D017147:Defibrillators, Implantable; D061345:Early Medical Intervention / Q000379:methods; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D017063:Outcome Assessment, Health Care; D013318:Stroke Volume
keywords: Cardiac resynchronization therapy; Early intervention; Heart failure; Implantable cardioverter defibrillator