title: Fibronectin is a potential cerebrospinal fluid and serum epilepsy biomarker.
abstract: OBJECTIVE
  Previous studies have demonstrated that fibronectin (FN) levels are increased in brain tissues from patients and animals with epilepsy. This study aimed to assess FN levels in cerebrospinal fluid (CSF) and serum samples from patients with epilepsy.
  
  
  METHODS
  Fibronectin levels were assessed in CSF and serum samples from 56 patients with epilepsy (27 and 29 individuals with intractable epilepsy and nonintractable epilepsy, respectively) and 25 healthy controls, using sandwich enzyme-linked immunosorbent assays (ELISA).
  
  
  RESULTS
  CSF-FN levels were higher in patients with epilepsy (8.07 ± 1.51 mg/l versus 6.20 ± 1.18 mg/l, p<0.05) than in the control group. In addition, serum-FN levels in the group with epilepsy and in the control group were 236.96 ± 65.7 mg/l and 181.43 ± 72.82 mg/l, respectively, indicating a statistically significant difference (p=0.01). Interestingly, serum- and CSF-FN levels in individuals with epilepsy were not affected by antiepileptic drug and duration of epilepsy. Of note, the increase of CSF- and serum-FN levels was more pronounced in subjects with intractable epilepsy than in patients with nonintractable epilepsy.
  
  
  CONCLUSIONS
  Serum- and CSF-FN levels constitute a potential clinical diagnostic biomarker for epilepsy and could also be used for differential diagnosis.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China. Electronic address: zqlhdd@126.com.
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Xi
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.affiliation: Chongqing Three Gorges Central Hospital, Chongqing 404000, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Wang
authors.affiliation: First Hospital of Shanxi Medical University, Shangxi 030001, China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, 1 You Yi Road, Chongqing 400016, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D000069279:Drug Resistant Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005260:Female; D005353:Fibronectins / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers; D005353:Fibronectins
keywords: Biomarker; Cerebrospinal fluid; ELISA; Epilepsy; Fibronectin; Serum