title: Bullous erythema nodosum leprosum manifesting in the post partum period with unusual features.
abstract: A 30 year old woman who presented with multiple numb patches on the body was initially diagnosed as borderline lepromatous leprosy and started on multidrug therapy for leprosy. She had an episode of Type 1 reaction during the fifth month of pregnancy. After delivery, she stopped therapy fearing harm to her child and developed an episode of Type 2 reaction. The reaction was unusual in that bullous lesions developed over previous leprosy patches which had initially become indurated, with associated neuritis. Histopathology revealed bullae with intense neutrophilic reaction and strong positivity for acid fast bacilli. There was no response to steroid therapy which was started for the reaction. Thalidomide had to be prescribed after stopping lactation by medical means. She responded dramatically to Thalidomide with regression of cutaneous lesions and neuritis. This patient is being reported as a very unusual manifestation of bullous erythema nodosum leprosum in the postpartum period responding dramatically to thalidomide.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Verma
authors.forename: Biju
authors.initials: B
authors.lastname: Vasudevan
authors.forename: Vijendran
authors.initials: V
authors.lastname: Pragasam
authors.forename: Nikhil
authors.initials: N
authors.lastname: Moorchung
authors.forename: Debdeep
authors.initials: D
authors.lastname: Mitra
authors.forename: Manoj
authors.initials: M
authors.lastname: Gopal
mesh_terms: D000328:Adult; D004893:Erythema Nodosum / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D015439:Leprosy, Borderline / Q000175:diagnosis* / Q000188:drug therapy; D015440:Leprosy, Lepromatous / Q000175:diagnosis* / Q000188:drug therapy; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy; D013792:Thalidomide / Q000627:therapeutic use
chemical_list: D007917:Leprostatic Agents; D013792:Thalidomide