title: Acute vasoreactivity test results in severe pulmonary hypertension patients with chronic obstructive pulmonary disease: our experience with 29 cases.
abstract: OBJECTIVE
  The aim of the current study is to evaluate acute vasoreactivity test (AVT) results in severe pulmonary hypertension patients with chronic obstructive pulmonary disease and to compare the demographical, clinical, and laboratory variables in positive and negative cases.
  
  
  METHODS
  This retrospective, clinical study was performed on 29 cases in the departments of cardiology and chest diseases of our tertiary care center. AVT was positive in 12 (41.4%) cases and negative in 17 (58.6%) cases. Demographical variables, cardiopulmonary indicators, and laboratory findings were compared in these two subgroups.
  
  
  RESULTS
  The mean age was 62.3±7.8 years for AVT negative group, while it was 64.8±7.3 years in AVT positive group (P=0.38). Except for the changes in systolic, diastolic, and mean pulmonary arterial pressures before and after iloprost administration, there were no statistically significant differences regarding any of the parameters under investigation in both groups.
  
  
  CONCLUSIONS
  Despite the high rate of positivity for AVT in severe pulmonary hypertension patients with chronic obstructive pulmonary disease, none of the variables under investigation displayed a noteworthy difference between AVT negative and positive groups. Identification of factors likely to influence AVT results is important for establishment of appropriate treatment protocols especially for AVT negative cases.
authors.affiliation: Department of Chest Diseases, Van Yuksek Ihtisas Training and Research Hospital, Van, Turkey.
authors.forename: Selvi
authors.initials: S
authors.lastname: Asker
authors.affiliation: Department of Cardiology, Van Yuksek Ihtisas Training and Research Hospital, Van, Turkey.
authors.forename: Muntecep
authors.initials: M
authors.lastname: Asker
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D062186:Arterial Pressure / Q000187:drug effects; D002302:Cardiac Output; D003935:Diagnostic Techniques, Cardiovascular; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D016285:Iloprost / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011651:Pulmonary Artery / Q000187:drug effects / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D062606:Tertiary Care Centers; D014421:Turkey; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost
keywords: acute vasoreactivity test; chronic obstructive pulmonary disease; pulmonary hypertension