title: Comparison of two misoprostol regimens for mid-trimester pregnancy terminations after FIGO's misoprostol dosage recommendation in 2012.
abstract: OBJECTIVE
  To compare the safety and efficacy of two misoprostol regimens for mid-trimester pregnancy terminations.
  
  
  METHODS
  Retrospective analysis of 263 cases of pregnancy terminations with misoprostol between 12 and 24 weeks was performed. Group 1 (total 129 patients) consisted of patients who were given 200 mcg vaginal misoprostol every 4 h until the abortion, whereas Group 2 patients (total 134 patients) were given misoprostol as in International Federation of Gynecology and Obstetrics's (FIGO) 2012 recommendation. In case of a previous cesarean section doses were halved in both groups. Primary outcomes of the study were the time to abortion and the total drug dose used. Secondary outcome was the rate of complications.
  
  
  RESULTS
  Total dose and time to abortion did not differ between the groups. As for complications, one patient (%0.8) in group 1 developed HELLP syndrome and had hysterotomy. One patient (%0.8) in group 2 had uterine rupture and had total hysterectomy. Two patients in both groups considered failure of induction and terminated with surgery (hysterotomy). Groups did not show difference in induction failure rates.
  
  
  CONCLUSIONS
  We respect the presence of dose recommendation stated by the FIGO and found similar results with our recent protocol. Other misoprostol regimens used worldwide should also be compared with this guideline in order to improve its efficacy.
authors.affiliation: a Department of Obstetrics & Gynecology and.
authors.forename: Cihan
authors.initials: C
authors.lastname: Cetin
authors.affiliation: a Department of Obstetrics & Gynecology and.
authors.forename: Selim
authors.initials: S
authors.lastname: Buyukkurt
authors.affiliation: b Department of Biostatistics , University of Cukurova School of Medicine , Adana , Turkey.
authors.forename: Gulsah
authors.initials: G
authors.lastname: Seydaoglu
authors.affiliation: a Department of Obstetrics & Gynecology and.
authors.forename: Bekir
authors.initials: B
authors.lastname: Kahveci
authors.affiliation: a Department of Obstetrics & Gynecology and.
authors.forename: Cenk
authors.initials: C
authors.lastname: Soysal
authors.affiliation: a Department of Obstetrics & Gynecology and.
authors.forename: Fatma Tuncay
authors.initials: FT
authors.lastname: Ozgunen
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol
keywords: Labor management/labor induction and augmentation; misoprostol; pregnancy loss; prenatal care; stillbirth