title: Gender effect on pre-attentive change detection in major depressive disorder patients revealed by auditory MMN.
abstract: Gender differences in rates of major depressive disorder (MDD) are well established, but gender differences in cognitive function have been little studied. Auditory mismatch negativity (MMN) was used to investigate gender differences in pre-attentive information processing in first episode MDD. In the deviant-standard reverse oddball paradigm, duration auditory MMN was obtained in 30 patients (15 males) and 30 age-/education-matched controls. Over frontal-central areas, mean amplitude of increment MMN (to a 150-ms deviant tone) was smaller in female than male patients; there was no sex difference in decrement MMN (to a 50-ms deviant tone). Neither increment nor decrement MMN differed between female and male patients over temporal areas. Frontal-central MMN and temporal MMN did not differ between male and female controls in any condition. Over frontal-central areas, mean amplitude of increment MMN was smaller in female patients than female controls; there was no difference in decrement MMN. Neither increment nor decrement MMN differed between female patients and female controls over temporal areas. Frontal-central MMN and temporal MMN did not differ between male patients and male controls. Mean amplitude of increment MMN in female patients did not correlate with symptoms, suggesting this sex-specific deficit is a trait- not a state-dependent phenomenon.
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang, China.
authors.forename: Zhengxue
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: Basic medical sciences school of Harbin Medical University, Heilongjiang, China.
authors.forename: Aiying
authors.initials: A
authors.lastname: Yang
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang, China.
authors.forename: Xiuxian
authors.initials: X
authors.lastname: Yang
authors.affiliation: The First Special Hospital of Harbin, Heilongjiang, China.
authors.forename: Congpei
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Xiongzhao
authors.initials: X
authors.lastname: Zhu
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Jincai
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Bai
authors.affiliation: The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China.
authors.forename: Hailian
authors.initials: H
authors.lastname: Sun
authors.affiliation: Center for Visual Art & Brain Cognition, Beijing Shengkun YanLun Technology Co.Ltd., Beijing, China. Electronic address: zhaolunlun@aliyun.com.
authors.forename: Lun
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Medical Psychology, Public Health Institute of Harbin Medical University, Heilongjiang, China. Electronic address: yanjie1965@163.com.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D003865:Major Depressive Disorder / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics
keywords: Auditory mismatch negativity; Event-related potentials; Gender; Information processing; Major depressive disorder