title: Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice.
abstract: The objective of this study was to assess the possible beneficial skeletal muscle preserving effects of ethanol extract of Schisandrae Fructus (EESF) on sciatic neurectomy- (NTX-) induced hindlimb muscle atrophy in mice. Here, calf muscle atrophy was induced by unilateral right sciatic NTX. In order to investigate whether administration of EESF prevents or improves sciatic NTX-induced muscle atrophy, EESF was administered orally. Our results indicated that EESF dose-dependently diminished the decreases in markers of muscle mass and activity levels, and the increases in markers of muscle damage and fibrosis, inflammatory cell infiltration, cytokines, and apoptotic events in the gastrocnemius muscle bundles are induced by NTX. Additionally, destruction of gastrocnemius antioxidant defense systems after NTX was dose-dependently protected by treatment with EESF. EESF also upregulated muscle-specific mRNAs involved in muscle protein synthesis but downregulated those involved in protein degradation. The overall effects of 500 mg/kg EESF were similar to those of 50 mg/kg oxymetholone, but it showed more favorable antioxidant effects. The present results suggested that EESF exerts a favorable ameliorating effect on muscle atrophy induced by NTX, through anti-inflammatory and antioxidant effects related to muscle fiber protective effects and via an increase in protein synthesis and a decrease in protein degradation.
authors.affiliation: Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Joo Wan
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea.
authors.forename: Sae-Kwang
authors.initials: SK
authors.lastname: Ku
authors.affiliation: Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea.
authors.forename: Sung Goo
authors.initials: SG
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 614-052, Republic of Korea.
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Han
authors.affiliation: Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Gi-Young
authors.initials: GY
authors.lastname: Kim
authors.affiliation: Anti-Aging Research Center and Blue-Bio Industry RIC, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea ; Department of Food and Nutrition, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Hwang
authors.affiliation: Anti-Aging Research Center and Blue-Bio Industry RIC, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea ; Department of Life Science and Biotechnology, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea.
authors.forename: Byung Woo
authors.initials: BW
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, Busan National University College of Medicine, Yangsan 626-870, Republic of Korea.
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 614-052, Republic of Korea ; Anti-Aging Research Center and Blue-Bio Industry RIC, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea.
authors.forename: Yung Hyun
authors.identifier: 0000-0002-1454-3124
authors.initials: YH
authors.lastname: Choi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D019587:Dietary Supplements; D000431:Ethanol / Q000737:chemistry; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D007150:Immunohistochemistry; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D053580:Muscle Strength / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D032141:Schisandra / Q000737:chemistry* / Q000378:metabolism; D012584:Sciatic Nerve / Q000601:surgery*
chemical_list: D000975:Antioxidants; D016207:Cytokines; D010936:Plant Extracts; D000431:Ethanol; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase