title: Proteome-scale identification and characterization of mitochondria targeting proteins of Mycobacterium avium subspecies paratuberculosis: Potential virulence factors modulating host mitochondrial function.
abstract: Mycobacterium avium subsp. paratuberculosis is the etiological agent of Johne's Disease among ruminants. During the course of infection, it expresses a number of proteins for its successful persistence inside the host that cause variety of physiological abnormalities in the host. Mitochondrion is one of the attractive targets for pathogenic bacteria. Employing a proteome-wide sequence and structural signature based approach we have identified 46 M. avium subsp. paratuberculosis proteins as potential targets for the host mitochondrial targeting. These may act as virulence factors modulating mitochondrial physiology for bacterial survival and immune evasion inside the host cells.
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, 176206 Himachal Pradesh, India.
authors.forename: Aarti
authors.initials: A
authors.lastname: Rana
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, 176206 Himachal Pradesh, India.
authors.forename: Devender
authors.initials: D
authors.lastname: Kumar
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi 110025, India.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rub
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Shahpur, District-Kangra, 176206 Himachal Pradesh, India. Electronic address: yusuf@cuhimachal.ac.in.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akhter
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D054884:Host-Pathogen Interactions; D024101:Mitochondrial Proteins / Q000235:genetics*; D016927:Mycobacterium avium subsp. paratuberculosis / Q000235:genetics*; D021381:Protein Transport; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D024101:Mitochondrial Proteins; D037521:Virulence Factors
keywords: Exotoxins; Mitochondria targeting; Mycobacterium avium subsp. paratuberculosis; Pathogenicity factors; Vaccine; Virulence