title: Heat Shock Proteins, L-Arginine, and Asymmetric Dimethylarginine Levels in Patients With Obstructive Sleep Apnea Syndrome.
abstract: OBJECTIVE
  Vascular endothelial inflammation and enhanced oxidative stress are important factors in the pathogenesis of obstructive sleep apnea syndrome (OSAS). The aim of this study was to determine the levels of heat shock protein (HSP) 27, HSP70, HSP90, L-arginine, and asymmetric dimethylarginine (ADMA) in patients with OSAS and determine their relationship with cardiovascular (CV) risk factors.
  
  
  METHODS
  Forty patients with OSAS, comprising 26 with and 14 without traditional CV risk factors (obesity, hypercholesterolemia, diabetes, hypertension, and smoking), and 20 control subjects without OSAS were included. All patients underwent a full polysomnographic evaluation, and blood samples were obtained in the morning after the night the diagnostic study was performed.
  
  
  RESULTS
  No significant differences were found in serum HSP27 and HSP70 levels between the groups. HSP90 and ADMA levels increased significantly, whereas L-arginine levels decreased significantly in patients with OSAS, both with and without CV risk factors, compared with controls, but were not different among the subgroups. In all patients with OSAS, serum HSP70 levels were positively correlated with a percent time with saturation<90% (r=.349, P=.027). Serum L-arginine levels were negatively correlated with desaturation number (r=-.360, P=.022) and apnea-hypopnea index (r=-.354, P=.025) and positively correlated with mean oxygen saturation (r=.328, P=.039).
  
  
  CONCLUSIONS
  Serum levels of HSP90 and ADMA increased, whereas those of L-arginine decreased in patients with OSAS regardless of CV risk factors. These findings indicate the presence of oxidative stress and endothelial dysfunction in patients with OSAS.
authors.affiliation: Department of Chest Diseases, Firat University Faculty of Medicine, Elazıg, Turquía. Electronic address: inerda@gmail.com.
authors.forename: Erdal
authors.initials: E
authors.lastname: İn
authors.affiliation: Yedikule Teaching Hospital for Pulmonology and Thoracic Surgery, Estambul, Turquía.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Özdemir
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Firat University Faculty of Medicine, Elazıg, Turquía.
authors.forename: Dilara
authors.initials: D
authors.lastname: Kaman
authors.affiliation: Yedikule Teaching Hospital for Pulmonology and Thoracic Surgery, Estambul, Turquía.
authors.forename: Sinem Nedime
authors.initials: SN
authors.lastname: Sökücü
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood*; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D004198:Disease Susceptibility; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D018384:Oxidative Stress; D017286:Polysomnography; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D006360:Heat-Shock Proteins; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: Asymmetric dimethylarginine; Dimetilarginina asimétrica; Disfunción endotelial; Endothelial dysfunction; Estrés oxidativo; Heat shock proteins; L-arginina; L-arginine; Obstructive sleep apnea syndrome; Oxidative stress; Proteínas de estrés; Síndrome de apnea obstructiva del sueño