title: Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities.
abstract: Tanzawaic acids M (1), N (2), O (3) and P (4) and the known tanzawaic acids B (5) and E (6), have been isolated from an extract of a cultured marine-derived fungus (strain CF07370) identified as a member of the genus Penicillium. The structures of 1-4 were determined based on spectroscopic evidence. The antimicrobial and cytotoxic activities of compounds 1-6 were evaluated.
authors.affiliation: Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico F. Sánchez, 3, 38206 La Laguna, Tenerife, Spain. mcueto@ipna.csic.es.
authors.forename: Faviola
authors.initials: F
authors.lastname: Cardoso-Martínez
authors.forename: José M
authors.initials: JM
authors.lastname: de la Rosa
authors.forename: Ana R
authors.initials: AR
authors.lastname: Díaz-Marrero
authors.forename: José
authors.initials: J
authors.lastname: Darias
authors.forename: Claudia
authors.initials: C
authors.lastname: Cerella
authors.forename: Marc
authors.initials: M
authors.lastname: Diederich
authors.forename: Mercedes
authors.initials: M
authors.lastname: Cueto
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D002264:Carboxylic Acids