title: Enantioselectivity in Catalytic Asymmetric Fischer Indolizations Hinges on the Competition of π-Stacking and CH/π Interactions.
abstract: Computational analyses of the first catalytic asymmetric Fischer indolization (J. Am. Chem. Soc. 2011, 133, 18534) reveal that enantioselectivity arises from differences in hydrogen bonding and CH/π interactions between the substrate and catalyst in the operative transition states. This selectivity occurs despite strong π-stacking interactions that reduce the enantioselectivity.
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: Seguin
authors.forename: Tongxiang
authors.initials: T
authors.lastname: Lu
authors.forename: Steven E
authors.initials: SE
authors.lastname: Wheeler