title: Functional subregions of the human entorhinal cortex.
abstract: The entorhinal cortex (EC) is the primary site of interactions between the neocortex and hippocampus. Studies in rodents and nonhuman primates suggest that EC can be divided into subregions that connect differentially with perirhinal cortex (PRC) vs parahippocampal cortex (PHC) and with hippocampal subfields along the proximo-distal axis. Here, we used high-resolution functional magnetic resonance imaging at 7 Tesla to identify functional subdivisions of the human EC. In two independent datasets, PRC showed preferential intrinsic functional connectivity with anterior-lateral EC and PHC with posterior-medial EC. These EC subregions, in turn, exhibited differential connectivity with proximal and distal subiculum. In contrast, connectivity of PRC and PHC with subiculum followed not only a proximal-distal but also an anterior-posterior gradient. Our data provide the first evidence that the human EC can be divided into functional subdivisions whose functional connectivity closely parallels the known anatomical connectivity patterns of the rodent and nonhuman primate EC.
authors.affiliation: Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Maass
authors.affiliation: Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
authors.forename: David
authors.identifier: http://orcid.org/0000-0003-1558-1883
authors.initials: D
authors.lastname: Berron
authors.affiliation: Center for Neuroscience, University of California at Davis, Davis, United States.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Libby
authors.affiliation: Department of Psychology, University of California at Davis, Davis, United States.
authors.forename: Charan
authors.identifier: http://orcid.org/0000-0001-5835-6091
authors.initials: C
authors.lastname: Ranganath
authors.affiliation: German Center for Neurodegenerative Diseases, Magdeburg, Germany.
authors.forename: Emrah
authors.initials: E
authors.lastname: Düzel
mesh_terms: D000328:Adult; D063132:Connectome / Q000379:methods; D018728:Entorhinal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D013045:Species Specificity; D014796:Visual Perception / Q000502:physiology
keywords: entorhinal cortex; functional connectivity; high-resolution fMRI; hippocampus; human; neuroscience; parahippocampal cortex; perirhinal cortex