title: Tissue-specific sparse deconvolution for brain CT perfusion.
abstract: Enhancing perfusion maps in low-dose computed tomography perfusion (CTP) for cerebrovascular disease diagnosis is a challenging task, especially for low-contrast tissue categories where infarct core and ischemic penumbra usually occur. Sparse perfusion deconvolution has been recently proposed to effectively improve the image quality and diagnostic accuracy of low-dose perfusion CT by extracting the complementary information from the high-dose perfusion maps to restore the low-dose using a joint spatio-temporal model. However the low-contrast tissue classes where infarct core and ischemic penumbra are likely to occur in cerebral perfusion CT tend to be over-smoothed, leading to loss of essential biomarkers. In this paper, we propose a tissue-specific sparse deconvolution approach to preserve the subtle perfusion information in the low-contrast tissue classes. We first build tissue-specific dictionaries from segmentations of high-dose perfusion maps using online dictionary learning, and then perform deconvolution-based hemodynamic parameters estimation for block-wise tissue segments on the low-dose CTP data. Extensive validation on clinical datasets of patients with cerebrovascular disease demonstrates the superior performance of our proposed method compared to state-of-art, and potentially improve diagnostic accuracy by increasing the differentiation between normal and ischemic tissues in the brain.
authors.affiliation: School of Computing and Information Sciences, Florida International University, Miami, FL 33174, USA. Electronic address: rfang@cs.fiu.edu.
authors.forename: Ruogu
authors.initials: R
authors.lastname: Fang
authors.affiliation: School of Computing and Information Sciences, Florida International University, Miami, FL 33174, USA.
authors.forename: Haodi
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Computer Science and Engineering, University of Texas at Arlington, Arlington, TX 76019, USA.
authors.forename: Junzhou
authors.initials: J
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D059906:Neuroimaging / Q000379:methods*; D010477:Perfusion; D012372:ROC Curve; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Deconvolution; Dictionary learning; Ischemic detection; Low-dose CT perfusion; Tissue-specific