title: The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose.
abstract: OBJECTIVE
  To describe the clinical effects, pharmacokinetics, and pharmacodynamics of plasma and acetylcholinesterase in an aldicarb overdose.
  
  
  METHODS
  A 57-year-old female was found unconscious and incontinent of urine after ingesting aldicarb. She was bradycardic, hypotensive, hypersalivating, clammy, had small pupils, and generalized weakness. She was intubated, ventilated, and treated with large atropine doses (50 mg and 20 mg/h infusion) and adrenaline. She improved hemodynamically over 24 h, but remained comatose for another 24 h, before recovering without sequela. Aldicarb concentration at admission was 2.18 μg/ml and concentration-time data best fitted a two compartmental model with first order absorption and a time of ingestion 4.5 h preadmission. The half-life of distribution was 0.4 h and half-life of elimination, 13 h. Plasma cholinesterase concentration at admission was 0.3 kU/L (Reference range[RR]:4.3-10.6 kU/L) and red cell cholinesterase was 10 U/gHb (RR:38-66 U/gHb). The IC50 was 0.15 μg/ml and 0.26 μg/ml for plasma and red cell cholinesterase, respectively.
  
  
  CONCLUSIONS
  Aldicarb poisoning causes rapid onset severe toxicity with muscarinic and nicotinic excess, seizures, and decreased consciousness. Cholinesterases rapidly recover once aldicarb concentrations decrease and precede clinical recovery.
authors.affiliation: Emergency Department, Bundaberg Hospital , Bundaberg, Queensland , Australia.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Michael
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mostafa
authors.forename: Joyce M
authors.initials: JM
authors.lastname: Cooper
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Grice
authors.forename: Michael S
authors.initials: MS
authors.lastname: Roberts
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Isbister
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000448:Aldicarb / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D001285:Atropine / Q000627:therapeutic use; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D007306:Insecticides / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D008875:Middle Aged
chemical_list: D007306:Insecticides; D001285:Atropine; D000448:Aldicarb; D000110:Acetylcholinesterase; D002802:Cholinesterases
keywords: Carbamate; Other; Pharmacokinetics; Respiratory support