title: Adipokines influence the inflammatory balance in autoimmunity.
abstract: Over the past few decades, our understanding of the role of adipose tissue has changed dramatically. Far from simply being a site of energy storage or a modulator of the endocrine system, adipose tissue has emerged as an important regulator of multiple important processes including inflammation. Adipokines are a diverse family of soluble mediators with a range of specific actions on the immune response. Autoimmune diseases are perpetuated by chronic inflammatory responses but the exact etiology of these diseases remains elusive. While researchers continue to investigate these causes, millions of people continue to suffer from chronic diseases. To this end, an increased interest has developed in the connection between adipose tissue-secreted proteins that influence inflammation and the onset and perpetuation of autoimmunity. This review will focus on recent advances in adipokine research with specific attention on a subset of adipokines that have been associated with autoimmune diseases.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address: jack.hutcheson@utsouthwestern.edu.
authors.forename: Jack
authors.initials: J
authors.lastname: Hutcheson
mesh_terms: D054392:Adipokines / Q000276:immunology*; D052242:Adiponectin / Q000276:immunology; D052436:Adipose Tissue, White / Q000378:metabolism*; D015551:Autoimmunity / Q000276:immunology*; D018925:Chemokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D036341:Intercellular Signaling Peptides and Proteins / Q000276:immunology; D020738:Leptin / Q000276:immunology; D054409:Nicotinamide Phosphoribosyltransferase / Q000276:immunology; D009765:Obesity / Q000378:metabolism; D052243:Resistin / Q000276:immunology
chemical_list: D054392:Adipokines; D052242:Adiponectin; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; C478630:RARRES2 protein, human; D052243:Resistin; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Adipokine; Autoimmunity; Inflammation; White adipose tissue