title: Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages.
abstract: OBJECTIVE
  To assess and compare cortical thickness (CTh) of patients with prodromal Dementia with Lewy bodies (pro-DLB), prodromal Alzheimer's disease (pro-AD), DLB dementia (DLB-d), AD dementia (AD-d) and normal ageing.
  
  
  METHODS
  Study participants(28 pro-DLB, 27 pro-AD, 31 DLB-d, 54 AD-d and 33 elderly controls) underwent 3Tesla T1 3D MRI and detailed clinical and cognitive assessments. We used FreeSurfer analysis package to measure CTh and investigate patterns of cortical thinning across groups.
  
  
  RESULTS
  Comparison of CTh between pro-DLB and pro-AD (p<0.05, FDR corrected) showed more right anterior insula thinning in pro-DLB, and more bilateral parietal lobe and left parahippocampal gyri thinning in pro-AD. Comparison of prodromal patients to healthy elderly controls showed the involvement of the same regions. In DLB-d (p<0.05, FDR corrected) cortical thinning was found predominantly in the right temporo-parietal junction, and insula, cingulate, orbitofrontal and lateral occipital cortices. In AD-d(p<0.05, FDR corrected),the most significant areas affected included the entorhinal cortices, parahippocampal gyri and parietal lobes. The comparison of AD-d and DLB-d demonstrated more CTh in AD-d in the left entorhinal cortex (p<0.05, FDR corrected).
  
  
  CONCLUSIONS
  Cortical thickness is a sensitive measure for characterising patterns of grey matter atrophy in early stages of DLB distinct from AD. Right anterior insula involvement may be a key region at the prodromal stage of DLB and needs further investigation.
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Blanc
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Sean J
authors.initials: SJ
authors.lastname: Colloby
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Philippi
authors.affiliation: University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: de Pétigny
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Jung
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Demuynck
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Clélie
authors.initials: C
authors.lastname: Phillipps
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Anthony
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Alan
authors.initials: A
authors.lastname: Thomas
authors.affiliation: University Hospital of Strasbourg, Neuroradiology Service, Strasbourg, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bing
authors.affiliation: University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Lamy
authors.affiliation: University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France; University Hospital of Strasbourg, Hôpital de jour de gériatrie, Geriatry Service, Strasbourg, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Martin-Hunyadi
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom; Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
authors.forename: John T
authors.initials: JT
authors.lastname: O'Brien
authors.affiliation: University Hospital of Strasbourg, Neuropsychology Unit, Neurology Service, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France; University Hospital of Strasbourg, CMRR (Memory Resources and Research Centre), Strasbourg, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Cretin
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Ian
authors.initials: I
authors.lastname: McKeith
authors.affiliation: University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de MédecineTranslationnelle de Strasbourg), team IMIS/Neurocrypto, Strasbourg, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Armspach
authors.affiliation: Institute of Neuroscience, Campus for Aging and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D062706:Prodromal Symptoms