title: The chromatin fiber: multiscale problems and approaches.
abstract: The structure of chromatin, affected by many factors from DNA linker lengths to posttranslational modifications, is crucial to the regulation of eukaryotic cells. Combined experimental and computational methods have led to new insights into its structural and dynamical features, from interactions due to the flexible core histone tails or linker histones to the physical mechanism driving the formation of chromosomal domains. Here we present a perspective of recent advances in chromatin modeling techniques at the atomic, mesoscopic, and chromosomal scales with a view toward developing multiscale computational strategies to integrate such findings. Innovative modeling methods that connect molecular to chromosomal scales are crucial for interpreting experiments and eventually deciphering the complex dynamic organization and function of chromatin in the cell.
authors.affiliation: Department of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA.
authors.forename: Gungor
authors.initials: G
authors.lastname: Ozer
authors.affiliation: Department of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA; Current address: Department of Mathematics & Statistics and Viral Information Institute, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-7720, USA.
authors.forename: Antoni
authors.initials: A
authors.lastname: Luque
authors.affiliation: Department of Chemistry, 100 Washington Square East, New York University, New York, NY 10003, USA; Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 3663 Zhongshan Road North, Shanghai 200062, China. Electronic address: schlick@nyu.edu.
authors.forename: Tamar
authors.initials: T
authors.lastname: Schlick
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D009707:Nucleosomes / Q000737:chemistry / Q000378:metabolism; D058105:Polymerization
chemical_list: D002843:Chromatin; D009707:Nucleosomes