title: Widefield En Face Optical Coherence Tomography Imaging of Subretinal Drusenoid Deposits.
abstract: OBJECTIVE
  To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans.
  
  
  METHODS
  Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a prototype 100-kHz SS-OCT instrument (Carl Zeiss Meditec) with a central wavelength of 1,050 nm. Seven en face slabs were evaluated with thicknesses from 20 to 55 µm and positioned at distances up to 55 µm above the retinal pigment epithelium (RPE). A montage of 6 × 6 mm SD-OCT en face images of the posterior pole from each patient was compared with a 9 × 12 mm SS-OCT single en face slab image and with color, autofluorescence, and infrared reflectance images.
  
  
  RESULTS
  A total of 160 patients (256 eyes) underwent scanning with both OCT instruments; 57 patients (95 eyes) also underwent multimodal fundus imaging. Of 95 eyes, 32 (34%) were diagnosed with reticular pseudodrusen (RPD) using multimodal imaging. All eyes with RPD demonstrated a pattern of SDD on widefield en face OCT similar to that observed for RPD. The en face slab image that consistently identified SDD was the 20-µm thick slab with boundaries from 35 to 55 µm above the RPE.
  
  
  CONCLUSIONS
  Widefield en face slab imaging with SD-OCT and SS-OCT can detect SDD and could replace multimodal imaging for the diagnosis of RPD in the future.
authors.forename: Karen B
authors.initials: KB
authors.lastname: Schaal
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Legarreta
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.forename: John E
authors.initials: JE
authors.lastname: Legarreta
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Cheng
authors.forename: Paul F
authors.initials: PF
authors.lastname: Stetson
authors.forename: Ming
authors.initials: M
authors.lastname: Cai
authors.forename: Michal
authors.initials: M
authors.lastname: Laron
authors.forename: Mary
authors.initials: M
authors.lastname: Durbin
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D000368:Aged; D005260:Female; D057092:Geographic Atrophy / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009887:Ophthalmoscopy; D011446:Prospective Studies; D015593:Retinal Drusen / Q000175:diagnosis*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence