title: Biomarkers in Hematological Malignancies: A Review of Molecular Testing in Hematopathology.
abstract: BACKGROUND
  Molecular interrogation of genetic information has transformed our understanding of disease and is now routinely integrated into the workup and monitoring of hematological malignancies. In this article, a brief but comprehensive review is presented of state-of-the-art testing in hematological disease.
  
  
  METHODS
  The primary medical literature and standard textbooks in the field were queried and reviewed to assess current practices and trends for molecular testing in hematopathology by disease.
  
  
  RESULTS
  Pertinent materials were summarized under appropriate disease categories.
  
  
  CONCLUSIONS
  Molecular testing is well entrenched in the diagnostic and therapeutic pathways for hematological malignancies, with rapid growth and insights emerging following the integration of next-generation sequencing into the clinical workflow.
authors.affiliation: Department of Hematopathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA. Mohammad.Hussaini@Moffitt.org.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hussaini
mesh_terms: D014408:Biomarkers, Tumor; D020732:Cytogenetic Analysis / Q000379:methods*; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D017421:Sequence Analysis; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor