title: Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline.
abstract: Preventive neuroradiology is a new concept supported by growing literature. The main rationale of preventive neuroradiology is the application of multimodal brain imaging toward early and subclinical detection of brain disease and subsequent preventive actions through identification of modifiable risk factors. An insightful example of this is in the area of age-related cognitive decline, mild cognitive impairment, and dementia with potentially modifiable risk factors such as obesity, diet, sleep, hypertension, diabetes, depression, supplementation, smoking, and physical activity. In studying this link between lifestyle and cognitive decline, brain imaging markers may be instrumental as quantitative measures or even indicators of early disease. The purpose of this article is to provide an overview of the major studies reflecting how lifestyle factors affect the brain and cognition aging. In this hot topics review, we will specifically focus on obesity and physical activity.
authors.affiliation: From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.) cyrusraji@gmail.com.
authors.forename: C A
authors.initials: CA
authors.lastname: Raji
authors.affiliation: Psychiatry (H.E., G.S.) Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Eyre
authors.affiliation: From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.).
authors.forename: S H
authors.initials: SH
authors.lastname: Wei
authors.affiliation: Neurology (D.E.B.).
authors.forename: D E
authors.initials: DE
authors.lastname: Bredesen
authors.affiliation: School of Medicine (S.M.), Deakin University, Geelong, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Moylan
authors.affiliation: Department of Radiology (M.L.).
authors.forename: M
authors.initials: M
authors.lastname: Law
authors.affiliation: Psychiatry (H.E., G.S.).
authors.forename: G
authors.initials: G
authors.lastname: Small
authors.affiliation: Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California.
authors.forename: P M
authors.initials: PM
authors.lastname: Thompson
authors.affiliation: Department of Neurosurgery (R.M.F.), University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: R M
authors.initials: RM
authors.lastname: Friedlander
authors.affiliation: Nuclear Medicine (D.H.S.), University of California at Los Angeles Medical Center, University of California at Los Angeles, Los Angeles, California.
authors.forename: D H
authors.initials: DH
authors.lastname: Silverman
authors.affiliation: Discipline of Psychiatry (H.E., B.T.B.), University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: B T
authors.initials: BT
authors.lastname: Baune
authors.affiliation: From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.).
authors.forename: T A
authors.initials: TA
authors.lastname: Hoang
authors.affiliation: From the Departments of Radiology (C.A.R., S.H.W., T.A.H., N.S.).
authors.forename: N
authors.initials: N
authors.lastname: Salamon
authors.affiliation: Laboratory of Neuroimaging (P.M.T., A.W.T.), University of Southern California, Los Angeles, California.
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
authors.affiliation: Departments of Radiology and Epidemiology (M.W.V.), Erasmus University Medical Center, Rotterdam, the Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Vernooij
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D001921:Brain; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology / Q000517:prevention & control*; D003863:Depression / Q000150:complications; D048909:Diabetes Complications / Q000175:diagnosis; D003952:Diagnostic Imaging; D006801:Humans; D006973:Hypertension / Q000150:complications; D008019:Life Style; D012106:Research; D012307:Risk Factors