title: Microstructure, corrosion behavior and cytotoxicity of biodegradable Mg-Sn implant alloys prepared by sub-rapid solidification.
abstract: In this study, biodegradable Mg-Sn alloys were fabricated by sub-rapid solidification, and their microstructure, corrosion behavior and cytotoxicity were investigated by using optical microscopy, scanning electron microscopy equipped with an energy dispersive X-ray spectroscopy, X-ray diffraction, immersion test, potentiodynamic polarization test and cytotoxicity test. The results showed that the microstructure of Mg-1Sn alloy was almost equiaxed grain, while the Mg-Sn alloys with higher Sn content (Sn≥3 wt.%) displayed α-Mg dendrites, and the secondary dendrite arm spacing of the primary α-Mg decreased significantly with increasing Sn content. The Mg-Sn alloys consisted of primary α-Mg matrix, Sn-rich segregation and Mg2Sn phase, and the amount of Mg2Sn phases increased with increasing Sn content. Potentiodynamic polarization and immersion tests revealed that the corrosion rates of Mg-Sn alloys increased with increasing Sn content. Cytotoxicity test showed that Mg-1Sn and Mg-3Sn alloys were harmless to MG63 cells. These results of the present study indicated that Mg-1Sn and Mg-3Sn alloys were promising to be used as biodegradable implants.
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Zhao
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China; Chongqing Academy of Science and Technology, Chongqing 401123, China. Electronic address: fspan@cqu.edu.cn.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Pan
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors.forename: Hucheng
authors.initials: H
authors.lastname: Pan
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.affiliation: College of Materials Science and Engineering, Chongqing University, Chongqing 400044, China; National Engineering Research Center for Magnesium Alloys, Chongqing University, Chongqing 400044, China.
authors.forename: Aitao
authors.initials: A
authors.lastname: Tang
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D045744:Cell Line, Tumor; D003343:Corrosion; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D013052:Spectrometry, X-Ray Emission; D014001:Tin / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014001:Tin; D008274:Magnesium
keywords: Biodegradable; Corrosion; Magnesium alloy; Orthopedic implant; Tin