title: Potential relationship between Hashimoto's thyroiditis and BRAF(V600E) mutation status in papillary thyroid cancer.
abstract: The purpose of this study was to evaluate the potential relationship between Hashimoto's thyroiditis and BRAF(V600E) mutation status in patients with papillary thyroid carcinoma (PTC).
  
  
  
  A total of 619 patients with PTC who underwent total thyroidectomy with lymph node dissection were enrolled in this study. Univariable and multivariate analyses were used.
  
  
  
  Hashimoto's thyroiditis was present in 35.9% (222 of 619) of PTCs. Multivariate logistic regressions showed that BRAF(V600E) mutation, sex, extrathyroidal extension, and lymph node metastasis were independent factors for Hashimoto's thyroiditis. Female sex, more frequent extrathyroidal extension, and a higher incidence of lymph node metastasis were significantly associated with PTCs accompanied by BRAF(V600E) mutation without Hashimoto's thyroiditis compared with PTCs accompanied by BRAF(V600E) mutation with Hashimoto's thyroiditis.
  
  
  
  Hashimoto's thyroiditis was negatively associated with BRAF(V600E) mutation, extrathyroidal extension, and lymph node metastasis. In addition, Hashimoto's thyroiditis was related to less lymph node metastasis and extrathyroidal extension in PTCs with BRAF(V600E) mutation. Therefore, Hashimoto's thyroiditis is a potentially protective factor in PTC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1019-E1025, 2016.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Zeng
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Lang-Ping
authors.initials: LP
authors.lastname: Jin
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: En-Dong
authors.initials: ED
authors.lastname: Chen
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Si-Yang
authors.initials: SY
authors.lastname: Dong
authors.affiliation: Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Ye-Feng
authors.initials: YF
authors.lastname: Cai
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Guan-Li
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Chun
authors.initials: C
authors.lastname: Jin
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
authors.forename: Ou-Chen
authors.initials: OC
authors.lastname: Wang
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009154:Mutation; D037981:Neck Dissection; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000150:complications / Q000235:genetics*; D013965:Thyroidectomy
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAFV600E mutation; Hashimoto' s thyroiditis; aggressive factors; protective factor; thyroid cancer