title: Correlation between the cystathionine-γ-lyase (CES) and the severity of peptic ulcer disease.
abstract: BACKGROUND
  The infection of Helicobacter pylori (H. pylori) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H2S) production in H. pylori-induced gastric ulcer disease.
  
  
  OBJECTIVE
  The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease.
  
  
  METHODS
  One hundred and eight patients were selected based on the determination of gastric ulcer and the infection of Helicobacter pylori (H. pylori), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori-positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8.
  
  
  RESULTS
  The expression of CSE, NF-κB and IL-8 was higher in the gastric ulcer group than control group (p<0.05). Compared with the H. pylori-negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H. pylori-positive gastric ulcer group (p<0.05). For H. pylori-negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p<0.05) and IL-8 (r=0.95, p<0.05). For H. pylori-positive gastric ulcer group, the expression of CSE also positively correlated with the expression of NF-κB (r=0.99, p<0.05) and IL-8 (r=0.85, p<0.05).
  
  
  CONCLUSIONS
  The expression of CSE was positively correlated with the severity of gastric ulcer.
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Wan
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Changsha 410013, Central South University, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
authors.forename: Can-Xia
authors.initials: CX
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, The Third Xiangya Hospital, Changsha 410013, Central South University, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003542:Cystathionine gamma-Lyase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000378:metabolism* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism; D016209:Interleukin-8 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism; D010437:Peptic Ulcer / Q000378:metabolism / Q000382:microbiology*; D012333:RNA, Messenger; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012720:Severity of Illness Index
chemical_list: D016209:Interleukin-8; D016328:NF-kappa B; D012333:RNA, Messenger; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide
keywords: Helicobacter pylori; cystathionine-γ-lyase (CSE); gastric ulcer; hydrogen sulfide (H2S)