title: Phenolic composition and biological activities of Salvia halophila and Salvia virgata from Turkey.
abstract: The aerial parts of Salvia halophila and Salvia virgata were subjected to Soxhlet extraction with different solvents such as n-hexane, ethyl acetate, methanol, and aqueous methanol (50%). Plants were also extracted with water under reflux. The effects of the extracts were studied in p-benzoquinone-induced abdominal constriction test for the assessment of antinociceptive activity and carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced ear edema models in mice for the anti-inflammatory activity. The extracts were analysed using a HPLC-PDA method. Results showed that methanol extract of S. virgata significantly inhibited carrageenan-induced paw edema and p-benzoquinone-induced abdominal constriction at 100mg/kg dose, while it showed no effect in the TPA-induced ear edema. On the other hand, the other extracts did not show any inhibitory antinociceptive and anti-inflammatory activities in these in vivo models. Rosmarinic acid was found as main constituent in the extracts, while caffeic acid and luteolin derivatives were also detected.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey. Electronic address: esrak@gazi.edu.tr.
authors.forename: Esra Küpeli
authors.initials: EK
authors.lastname: Akkol
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Göger
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
authors.forename: Müberra
authors.initials: M
authors.lastname: Koşar
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
authors.forename: K Hüsnü Can
authors.initials: KH
authors.lastname: Başer
keywords: 12-O-Tetradecanoyl-13-acetate induced edema; Anti-inflammatory activity; Antinociceptive activity; Carrageenan-induced edema; Lamiaceae; Salvia halophila; Salvia virgata