title: Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression.
abstract: A putative right anterior insula metabolism biomarker predictive of treatment outcomes was retrospectively applied to 30 depressed psychotherapy--or escitalopram-treated nonremitters who entered combination treatment. Patients whose added treatment matched the biomarker-indicated treatment remitted more often than biomarker-mismatched patients.
authors.affiliation: From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
authors.forename: Boadie W
authors.initials: BW
authors.lastname: Dunlop
authors.affiliation: From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
authors.forename: Mary E
authors.initials: ME
authors.lastname: Kelley
authors.affiliation: From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
authors.forename: Callie L
authors.initials: CL
authors.lastname: McGrath
authors.affiliation: From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
authors.forename: W Edward
authors.initials: WE
authors.lastname: Craighead
authors.affiliation: From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
authors.forename: Helen S
authors.initials: HS
authors.lastname: Mayberg
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism*; D015283:Citalopram; D003863:Depression / Q000188:drug therapy* / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D015283:Citalopram