title: Oncologic outcome after local recurrence of chondrosarcoma: Analysis of prognostic factors.
abstract: BACKGROUND
  Literature on outcome after local recurrence (LR) in chondrosarcoma is scarce and better appreciation of prognostic factors is needed.
  
  
  OBJECTIVE
  (1) To evaluate post-LR oncologic outcomes of disease-specific survival and subsequent LR and (2) to identify prognostic factors for post-LR oncologic outcomes.
  
  
  METHODS
  Review of 28 patients with locally recurrent chondrosarcoma from the original cohort of 150 patients, who were treated surgically with or without adjuvants between 1982 and 2011, was performed. Mean age was 46 years (range, 21-73) which included 20 males and 8 females with mean follow up of 8.4 ± 7.5 years (range, 1.2-31.0).
  
  
  RESULTS
  Post-LR survival at 5 years was 58.6 ± 10.3%. Age greater than 50 years (P = 0.011) and LR occurring within 1 year of primary surgery (P = 0.011) independently predicted poor survival. Seven patients suffered subsequent LR, which was significantly affected by surgical margin for LR (P = 0.038).
  
  
  CONCLUSIONS
  Long-term survival of locally recurrent chondrosarcoma is achievable in a substantial number of patients. Older age at onset of LR and shorter interval from primary surgery to LR identifies high risk patients for poor post-LR survival while, wide surgical margins at LR surgery reduces the risk of subsequent LR.
authors.affiliation: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Han-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Srimanth S
authors.initials: SS
authors.lastname: Bindiganavile
authors.affiliation: Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Korea.
authors.forename: Ilkyu
authors.initials: I
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D002813:Chondrosarcoma / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D055815:Young Adult
keywords: axial; chondrosarcoma; grade; local recurrence; metastasis