title: The effect of rifampin on the pharmacokinetics of edoxaban in healthy adults.
abstract: OBJECTIVE
  The oral direct factor Xa inhibitor edoxaban is a P-glycoprotein (P-gp) substrate metabolized via carboxylesterase-1 and cytochrome P450 (CYP) 3A4/5. The effect of rifampin-induced induction of P-gp and CYP3A4/5 on transport and metabolism of edoxaban through the CYP3A4/5 pathway was investigated in a single-dose edoxaban study.
  
  
  METHODS
  This was a phase 1, open-label, two-treatment, two-period, single-sequence drug interaction study in healthy adults. All subjects received a single oral 60 mg edoxaban dose in period 1, and 7 days of 600 mg rifampin (2 × 300 mg capsules once daily) with a single oral edoxaban 60 mg dose administered concomitantly on day 7 in period 2. A 6-day washout period separated the treatments. Plasma concentrations of edoxaban and its metabolites M4 and M6 were measured, and limited assessments of pharmacodynamic markers of coagulation were performed.
  
  
  RESULTS
  In total, 34 healthy subjects were enrolled; 32 completed the study. Coadministration of rifampin with edoxaban decreased edoxaban exposure but increased active metabolite exposure. Rifampin increased apparent oral clearance of edoxaban by 33 % and decreased its half-life by 50 %. Anticoagulant effects based on the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) with and without rifampin at early time points were maintained to a greater-than-expected degree than with edoxaban exposure alone, presumably because of an increased contribution from the active metabolites. Edoxaban was well tolerated in this healthy adult population.
  
  
  CONCLUSIONS
  Rifampin reduced exposure to edoxaban while increasing exposure to its active metabolites M4 and M6. PT and aPTT at early time points did not change appreciably; however, the data should be interpreted with caution.
authors.affiliation: Daiichi Sankyo Pharma Development, 399 Thornall Street, Edison, NJ, 08837, USA, jmendell@dsi.com.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Mendell
authors.forename: Shuquan
authors.initials: S
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.forename: Madhuri
authors.initials: M
authors.lastname: Desai
authors.forename: Dolly A
authors.initials: DA
authors.lastname: Parasramupria
mesh_terms: D000328:Adult; D004347:Drug Interactions; D065427:Factor Xa Inhibitors / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D011725:Pyridines / Q000493:pharmacokinetics*; D012293:Rifampin / Q000494:pharmacology*; D013844:Thiazoles / Q000493:pharmacokinetics*
chemical_list: D065427:Factor Xa Inhibitors; D011725:Pyridines; D013844:Thiazoles; C552171:edoxaban; D012293:Rifampin