title: Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2.
abstract: Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Ou
authors.initials: O
authors.lastname: Lv
authors.forename: Fenggang
authors.initials: F
authors.lastname: Zhou
authors.forename: Qingsong
authors.initials: Q
authors.lastname: Li
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Wu
authors.forename: Yongri
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D039821:Monoterpenes / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000080462:Acyclic Monoterpenes; D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D039821:Monoterpenes; D016328:NF-kappa B; C018584:linalool; D051547:Heme Oxygenase-1; D015232:Dinoprostone