title: Investigation of antidiabetic action of Antidesma bunius extract in type 1 diabetes.
abstract: BACKGROUND
  Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant.
  
  
  OBJECTIVE
  To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes.
  
  
  METHODS
  A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabetic rats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed.
  
  
  RESULTS
  Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the β-cells.
  
  
  CONCLUSIONS
  The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.
authors.affiliation: National Organization for Drug Control and Research , Cairo , Egypt .
authors.forename: Walid Hamdy
authors.initials: WH
authors.lastname: El-Tantawy
authors.forename: Nermin Diaa
authors.initials: ND
authors.lastname: Soliman
authors.forename: Dina
authors.initials: D
authors.lastname: El-naggar
authors.forename: Azza
authors.initials: A
authors.lastname: Shafei
mesh_terms: D000496:Alloxan; D000681:Amylases / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D005260:Female; D006003:Glycogen / Q000819:agonists / Q000096:biosynthesis; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000187:drug effects* / Q000473:pathology; D007928:Lethal Dose 50; D008049:Lipase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D029581:Malpighiaceae / Q000737:chemistry*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D000496:Alloxan; D006003:Glycogen; D002784:Cholesterol; D008049:Lipase; D000681:Amylases
keywords: Alloxan; TC; TG; insulin; liver glycogen