title: Anti-inflammatory diterpene dimers from the root barks of Aphanamixis grandifolia.
abstract: A total of 14 new diterpene dimers, aphanamenes C-P ()1-14, with four known homologous compounds were isolated from the root barks of Aphanamixis grandifolia Bl. The structures of these compounds were elucidated by spectroscopic analyses, and their absolute configurations were determined using the CD exciton chirality method. In addition, all the compounds exhibited significant inhibition of lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages, with IC50 values between 7.75 and 38.23 μM.
authors.affiliation: State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China. luojun1981ly@163.com cpu_lykong@126.com.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Yang-Mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Luo
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Kong
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D053898:Biosynthetic Pathways / Q000187:drug effects; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D016923:Cell Death / Q000187:drug effects; D002942:Circular Dichroism; D019281:Dimerization; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D000067996:RAW 264.7 Cells; D013237:Stereoisomerism
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes