title: Neurocognitive Function Following Therapy for Low-Grade Gliomas.
abstract: Low-grade gliomas (LGGs) are a heterogenous group of primary brain neoplasms that most commonly occur in children and young adults, characterized by a slow, indolent course and overall favorable prognosis. Standard therapies used to treat LGGs have included surgical resection, radiotherapy, chemotherapy, or a combination thereof. Given the anticipated long survival and typical young age of patients with LGG, the long-term sequelae of therapy require special attention, especially as they affect neurocognitive function and quality of life. We review the complex interplay of baseline and treatment-related factors that perturb neurocognition as well as the effect of each treatment modality on altering neurocognitive outcomes in this patient population.
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: mfmcalee@mdanderson.org.
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: McAleer
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Paul D
authors.initials: PD
authors.lastname: Brown
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000528:radiation effects / Q000601:surgery; D001932:Brain Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003072:Cognition Disorders / Q000209:etiology*; D003131:Combined Modality Therapy / Q000009:adverse effects; D005910:Glioma / Q000628:therapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D013514:Surgical Procedures, Operative / Q000009:adverse effects