title: Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[18F]-ADAM PET study.
abstract: OBJECTIVE
  Suicide is an important issue in the military service, since it can influence military morale and create dangerous situations for other personnel. The serotonin transporter (SERT) has been suggested to be involved in the pathophysiology of depression and suicidal behaviours. The aims of this study were to examine whether the brain SERT availability differs between military conscripts with depression and control subjects, and whether suicidal ideation is correlated with SERT availability.
  
  
  METHODS
  We used N,N-dimethyl-2-(2-amino-4-[(18)F]-fluorophenylthio)benzylamine (4-[(18)F]-ADAM) as a radioligand for positron emission tomography (PET) imaging. All participants completed the Hamilton Depression Rating Scale and Beck Scale for Suicide Ideation (BSS) prior to PET imaging.
  
  
  RESULTS
  The effect of major depression and BSS scores had an interaction on SERT availability. After adjusting for the BSS score, subjects with depression had lower SERT availability than control subjects (F1,17 = 23.85, P < 0.001). A positive correlation between SERT availability and BSS scores was observed in the depression group (F1,8 = 30.67, P = 0.001). The status of depression and intensity of suicidal ideation exert opposite effects on SERT availability.
  
  
  CONCLUSIONS
  The extent of suicidal ideation may moderate the reduction effect in SERT binding observed in major depression in male military conscripts.
authors.affiliation: a Department of Psychiatry , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.|b Department of Psychiatry , Penghu Branch, Tri-Service General Hospital , Penghu , Taiwan.
authors.forename: Yi-Wei
authors.initials: YW
authors.lastname: Yeh
authors.affiliation: c Department of Psychiatry , Beitou Branch, Tri-Service General Hospital , Taipei , Taiwan.
authors.forename: Pei-Shen
authors.initials: PS
authors.lastname: Ho
authors.affiliation: a Department of Psychiatry , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.|d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Chen
authors.affiliation: a Department of Psychiatry , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.|d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Shin-Chang
authors.initials: SC
authors.lastname: Kuo
authors.affiliation: c Department of Psychiatry , Beitou Branch, Tri-Service General Hospital , Taipei , Taiwan.|d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Chih-Sung
authors.initials: CS
authors.lastname: Liang
authors.affiliation: d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.|e Department of Neurology , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Che-Hung
authors.initials: CH
authors.lastname: Yen
authors.affiliation: d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.|f Department of Psychiatry , Taipei Branch, Buddhist Tzu Chi General Hospital , Taipei , Taiwan.
authors.forename: Chang-Chih
authors.initials: CC
authors.lastname: Huang
authors.affiliation: g Department of Nuclear Medicine , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.
authors.forename: Chyng-Yann
authors.initials: CY
authors.lastname: Shiue
authors.affiliation: g Department of Nuclear Medicine , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.|h Department of Nuclear Medicine , Changhua Christian Hospital , Changhua , Taiwan.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Huang
authors.affiliation: i Department of Biology & Anatomy , National Defense Medical Center , Taipei , Taiwan.
authors.forename: Kuo-Hsing
authors.initials: KH
authors.lastname: Ma
authors.affiliation: j Department of Psychiatry , National Cheng Kung University , Tainan , Taiwan.
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.affiliation: a Department of Psychiatry , Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan.|d Graduate Institute of Medical Sciences, National Defense Medical Center , Taipei , Taiwan.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Huang
mesh_terms: D000328:Adult; D001596:Benzylamines; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008889:Military Personnel / Q000523:psychology*; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D059020:Suicidal Ideation; D055815:Young Adult
chemical_list: D001596:Benzylamines; C475911:N,N-dimethyl-2-(2-amino-4-fluorophenylthio)benzylamine; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: 4-[18F]-ADAM; depression; military conscript; serotonin transporter; suicide