title: A TAD Closer to Understanding Dosage Compensation.
abstract: Eukaryotic chromosomes are organized into topological domains, but how these are established and maintained is poorly understood. Writing in Nature, Crane et al. (2015) show that a specialized condensin complex enforces the domain boundaries along the C. elegans X chromosome to equalize transcription from the X between males and hermaphrodites.
authors.affiliation: MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, Scotland, UK. Electronic address: andrew.wood@igmm.ed.ac.uk.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wood
authors.affiliation: MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh EH4 2XU, Scotland, UK. Electronic address: wendy.bickmore@igmm.ed.ac.uk.
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Bickmore
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004303:Dosage Compensation, Genetic / Q000502:physiology*; D005260:Female; D008297:Male; D046912:Multiprotein Complexes / Q000378:metabolism*; D014960:X Chromosome / Q000378:metabolism*
chemical_list: D029742:Caenorhabditis elegans Proteins; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D000251:Adenosine Triphosphatases