title: [Factors associated with medication non-adherence in uncontrolled hypertensive males and females: ODACE study].
abstract: OBJECTIVE
  The aim of this study was (1) to measure adherence in males and females with uncontrolled hypertension, and (2) to identify factors associated with non-adherence to antihypertensive medication.
  
  
  METHODS
  Each general practitioner (GP) should include the first two male and the first two female patients with uncontrolled treated hypertension. Adherence to antihypertensive treatment was estimated by the GP and using the French League Against High blood pressure (FLAH) self-administered questionnaire. A stepwise logistic regression analysis was used to identify factors associated with non-adherence on the FLAH scale, independently in males and in females.
  
  
  RESULTS
  A total of 1630 males and 1612 females were included in the analysis. Adherence to treatment was significantly better in females or when estimated by the GP. Lack of motivation was the first factor associated with poor adherence in both sexes. Considering hypertension as a simple anomaly and not a disease that can lead to cardiac or cerebral disorders was the second common parameter in both sexes. Other common factors were: having monthly periods of financial difficulties in facing his/her needs and absence of regular screening for colon cancer.
  
  
  CONCLUSIONS
  Adherence to treatment is better in uncontrolled hypertensive females. Poor adherence is mainly associated with non-clinical factors. The lack of motivation is the most important element.
authors.affiliation: Service d'endocrinologie diabétologie maladies métaboliques, hôpital Avicenne & EA 3412, université Paris 13, Sorbonne Paris Cité, Assistance publique-Hôpitaux de Paris, 125, route de Stalingrad, 93000 Bobigny, France. Electronic address: gerard.reach@avc.aphp.fr.
authors.forename: G
authors.initials: G
authors.lastname: Reach
authors.affiliation: 118, rue de la Pompe, 75116 Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Guedj-Meynier
authors.affiliation: Monitoring Force Group, 38, rue Jean-Mermoz, bâtiment D, 78604 Maisons-Laffitte cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Darné
authors.affiliation: Service de cardiologie, centre hospitalier et universitaire de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.
authors.forename: D
authors.initials: D
authors.lastname: Herpin
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D016903:Drug Monitoring
chemical_list: D000959:Antihypertensive Agents
keywords: Epidemiology; Facteurs non cliniques; Hypertension artérielle non contrôlée; Medication adherence; Motivation; Non clinical factors; Observance médicamenteuse; Uncontrolled arterial hypertension; Épidémiologie