title: Chitosan nanoparticles as adenosine carriers.
abstract: The objective of this research project was to evaluate the potential use of chitosan (CS) nanoparticles (NPs) as a drug delivery system for the molecule adenosine. Adenosine is an essential drug used for treating several health issues especially irregular heart rhythm. However, due to its extremely short half-life in vivo (<10 s), the effective delivery of adenosine in clinical applications is a significant challenge. In this research, adenosine was encapsulated into NPs formed by ionic gelation of CS. The encapsulation efficiency and loading capacity of 20% and 3% were obtained, respectively, by forming a complex between CS NPs and adenosine. The obtained CS NPs had a spherical shape in the size range of 260.6 ± 20.1 nm. Spectrophotometry analysis of the adenosine released in vitro showed an initial burst release phase, a plateau phase, followed by a steady release over a week.
authors.affiliation: Department of Process Engineering and Applied Science, Dalhousie University , Halifax , Canada .
authors.forename: Mehdi
authors.initials: M
authors.lastname: Kazemzadeh-Narbat
authors.forename: Marla
authors.initials: M
authors.lastname: Reid
authors.forename: Marianne Su-Ling
authors.initials: MS
authors.lastname: Brooks
authors.forename: Amyl
authors.initials: A
authors.lastname: Ghanem
mesh_terms: D000241:Adenosine / Q000737:chemistry* / Q000493:pharmacokinetics*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D048271:Chitosan; D000241:Adenosine
keywords: Adenosine; chitosan; drug delivery systems; nanoparticles