title: Impact of mild versus moderate intensity aerobic walking exercise training on markers of bone metabolism and hand grip strength in moderate hemophilic A patients.
abstract: BACKGROUND
  Patients with hemophilia A have low bone density than healthy controls. It is now widely recognized that physical activity and sports are beneficial for patients with hemophilia.
  
  
  OBJECTIVE
  To compare the effects of mild and moderate intensity treadmill walking exercises on markers of bone metabolism and hand grip strength in male patients with moderate hemophilia A.
  
  
  METHODS
  Fifty male patients with moderate hemophilia, and age range from 25 to 45 years. The subjects were randomly assigned into 2 equal groups; the first group (A) received moderate intensity aerobic exercise training. The second group (B) received mild intensity aerobic exercise training.
  
  
  RESULTS
  There was a 32.1% and 24.8% increase in mean values of serum calcium and hand grip strength respectively and 22.7 % reduction in mean values of parathyroid hormone in moderate exercise training group (A). While there was a 15.1 % and 15 % increase in mean values of Serum Calcium and Hand grip strength respectively and 10.3 % reduction in mean values of parathyroid hormone in mild exercise training group(B). The mean values of serum calcium and hand grip strength were significantly increased, while the mean values of parathyroid hormone were significantly decreased in both groups . There were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.
  
  
  CONCLUSIONS
  Moderate intensity aerobic exercise training on treadmill is appropriate to improve markers of bone metabolism and hand grip strength in male patients with hemophilia A.
authors.affiliation: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Fadwa Al-Ghalib
authors.initials: FA
authors.lastname: Al-Sharif
authors.affiliation: Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Osama Hussien
authors.initials: OH
authors.lastname: Al-Jiffri
authors.affiliation: Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Shehab Mahmoud Abd
authors.initials: SM
authors.lastname: El-Kader
authors.affiliation: Department of Physical Therapy, Faculty of Applied Medical Sciences, King Abdulaziz University.
authors.forename: Eman Mohamed
authors.initials: EM
authors.lastname: Ashmawy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D016022:Case-Control Studies; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D018737:Hand Strength; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance; D012307:Risk Factors; D016896:Treatment Outcome; D016138:Walking
chemical_list: D015415:Biomarkers
keywords: Aerobic exercise; bone metabolism; hand grip strength; hemophilia