title: Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide-alkyne cycloaddition.
abstract: Metal-free 1,3-dipolar cycloaddition reactions have proven to be a powerful tool for the assembly of key heterocycles, in particular diversely functionalized 1,2,3-triazoles. A number of metal-free (3+2)-cycloaddition approaches have been developed up to date with the aim to circumvent the use of metal catalysts allowing these reactions to take place in biological systems without perturbation of the naturally occurring processes. This feature article specifically provides an overview of emerging metal-free synthetic routes, and their mechanistic features, in the formation of functionalized 1,2,3-triazoles.
authors.affiliation: Department of Chemistry, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, Brazil. mwpaixao@ufscar.br.
authors.forename: Carolina G S
authors.initials: CG
authors.lastname: Lima
authors.forename: Akbar
authors.initials: A
authors.lastname: Ali
authors.forename: Sander S
authors.initials: SS
authors.lastname: van Berkel
authors.forename: Bernhard
authors.initials: B
authors.lastname: Westermann
authors.forename: Márcio W
authors.initials: MW
authors.lastname: Paixão
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D061565:Cycloaddition Reaction; D007536:Isomerism; D007659:Ketones / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D007659:Ketones; D008670:Metals; D014230:Triazoles