title: An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles.
abstract: An efficient and unprecedented domino reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55-91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.
authors.affiliation: Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. wlxioc@cioc.ac.cn xuxy@cioc.ac.cn.
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Cai
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Tian
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Xu
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D018360:Crystallography, X-Ray; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D000078183:Oxindoles; D011759:Pyrrolidines / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D001388:Aziridines; D007211:Indoles; D000078183:Oxindoles; D011759:Pyrrolidines; D013141:Spiro Compounds; C022960:2-oxindole; C033132:aziridine