title: Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing.
abstract: Options for the treatment of cartilage defects include chondral resurfacing with abrasion, debridement, autologous chondrocyte transplantation (ACT), matrix-induced chondrocyte transplantation (MACI), or osteochondral autologous transplantation (OATS). This article describes the new method of autologous matrix-induced chondrogenesis (AMIC), a 1-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane by a partially autologous fibrin glue. Indications and contraindications are provided; a technical note is given. This method is primarily applied in osteochondral lesions of the knee and ankle joints; other joints may qualify.
authors.affiliation: Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland.
authors.forename: J P
authors.initials: JP
authors.lastname: Benthien
authors.affiliation: Department of Orthopaedic Surgery, University of Luebeck, Luebeck, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Behrens
keywords: AMIC; autologous cartilage repair; microfracturing