title: Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program.
abstract: BACKGROUND
  Single pulse transcranial magnetic stimulation (sTMS) is a novel treatment for acute migraine. Previous randomised controlled data demonstrated that sTMS is effective and well tolerated in the treatment of migraine with aura. The aim of the programme reported here was to evaluate patient responses in the setting of routine clinical practice.
  
  
  METHODS
  Migraine patients with and without aura treating with sTMS had an initial review (n = 426) and training call, and then participated in telephone surveys at week six (n = 331) and week 12 during a 3-month treatment period (n = 190).
  
  
  RESULTS
  Of patients surveyed with 3 month data (n = 190; episodic, n = 59; chronic, n = 131), 62 % reported pain relief, finding the device effective at reducing or alleviating migraine pain; in addition there was relief reported of associated features: nausea- 52 %; photophobia- 55 %; and phonophobia- 53 %. At 3 months there was a reduction in monthly headache days for episodic migraine, from 12 (median, 8-13 IQ range) to 9 (4-12) and for chronic migraine, a reduction from 24 (median, 16-30 IQ range) to 16 (10-30). There were no serious or unanticipated adverse events.
  
  
  CONCLUSIONS
  sTMS may be a valuable addition to options for the treatment of both episodic and chronic migraine.
authors.affiliation: eNeura Therapeutics, Sunnyvale, CA, USA, rbhola@eneura.com.
authors.forename: Ria
authors.initials: R
authors.lastname: Bhola
authors.forename: Evelyn
authors.initials: E
authors.lastname: Kinsella
authors.forename: Nicola
authors.initials: N
authors.lastname: Giffin
authors.forename: Sue
authors.initials: S
authors.lastname: Lipscombe
authors.forename: Fayyaz
authors.initials: F
authors.lastname: Ahmed
authors.forename: Mark
authors.initials: M
authors.lastname: Weatherall
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Goadsby
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D012001:Hyperacusis / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000628:therapy*; D009325:Nausea / Q000209:etiology / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D020795:Photophobia / Q000209:etiology / Q000628:therapy*; D010865:Pilot Projects; D050781:Transcranial Magnetic Stimulation / Q000379:methods*