title: Efficacy of a triclosan formula in controlling early subgingival biofilm formation: a randomized trial.
abstract: The aim of this study was to determine the efficacy of rinses with slurries of a dentifrice containing triclosan (TCS), as compared with rinses with slurries from a control dentifrice, in controlling early subgingival biofilm formation. A double-blind, randomized and cross-over clinical trial was designed, and 26 dental students were included. In the first period, participants were randomized to rinse with a TCS slurry or a control slurry, in a 12 h interval, and to refrain from mechanical cleaning. A Plaque Free Zone Index was assessed at 24 h, 48 h, 72 h and 96 h. After a washout period of 10 days, the second experimental period was conducted, following the same protocol as the first period, except that the slurry groups were switched. Use of the TCS slurry resulted in a significantly higher percentage of plaque-free surfaces, both at 24 h and at 72 h (p < 0.01). In the of 48-72 h interval, the triclosan slurry showed a lower percentage of sites converted to a score of 2 (38.1% for the test versus 40% for the control product, p = 0.015). In conclusion, rinsing with slurries of dentifrice containing TCS retards the down growth of bacterial biofilms from the supra- to the subgingival environment.
authors.affiliation: Department of Periodontology, School of Dentistry, Universidade de La República, Montevideo, Uruguay.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Andrade
authors.affiliation: Department of Periodontology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Weidlich
authors.affiliation: Department of Periodontology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Patrícia Daniela Melchiors
authors.initials: PD
authors.lastname: Angst
authors.affiliation: Department of Periodontology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Sabrina Carvalho
authors.initials: SC
authors.lastname: Gomes
authors.affiliation: Department of Periodontology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Rui Vicente
authors.initials: RV
authors.lastname: Oppermann
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005881:Gingiva / Q000187:drug effects / Q000382:microbiology*; D006801:Humans; D008297:Male; D010510:Periodontal Diseases / Q000382:microbiology / Q000517:prevention & control; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014260:Triclosan / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D014260:Triclosan