title: YAP and TAZ: a nexus for Hippo signaling and beyond.
abstract: The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGFβ), and Notch pathways.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Carsten Gram
authors.initials: CG
authors.lastname: Hansen
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Moroishi
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.|Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D000217:Acyltransferases; D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D000090683:Hippo Signaling Pathway; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D010750:Phosphoproteins / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D013312:Stress, Physiological; D014157:Transcription Factors / Q000502:physiology*; D015533:Transcriptional Activation; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human; D000217:Acyltransferases; C108675:TAFAZZIN protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Notch; Wnt; extracellular matrix; primary cilia; regeneration; stem cells