title: Potential for Stem Cell-Based Periodontal Therapy.
abstract: Periodontal diseases are highly prevalent and are linked to several systemic diseases. The goal of periodontal treatment is to halt the progression of the disease and regenerate the damaged tissue. However, achieving complete and functional periodontal regeneration is challenging because the periodontium is a complex apparatus composed of different tissues, including bone, cementum, and periodontal ligament. Stem cells may represent an effective therapeutic tool for periodontal regeneration due to their plasticity and their ability to regenerate different tissues. This review presents and critically analyzes the available information on stem cell-based therapy for the regeneration of periodontal tissues and suggests new avenues for the development of more effective therapeutic protocols.
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.
authors.forename: Seyed Hossein
authors.initials: SH
authors.lastname: Bassir
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.|Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.|Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, Massachusetts.
authors.forename: Wichaya
authors.initials: W
authors.lastname: Wisitrasameewong
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.
authors.forename: Justin
authors.initials: J
authors.lastname: Raanan
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.
authors.forename: Sasan
authors.initials: S
authors.lastname: Ghaffarigarakani
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.
authors.forename: Jamie
authors.initials: J
authors.lastname: Chung
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.|Department of Applied Oral Sciences, The Forsyth Institute, Cambridge, Massachusetts.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Freire
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.
authors.forename: Luciano C
authors.initials: LC
authors.lastname: Andrada
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts.|Harvard Stem Cell Institute, Boston, Massachusetts.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Intini
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D010513:Periodontal Ligament / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D023822:Tissue Engineering / Q000379:methods