title: A new diagnostic marker for acute pulmonary embolism in emergency department: mean platelet volume.
abstract: OBJECTIVE
  To investigate the diagnostic importance of mean platelet volume (MPV) on acute pulmonary embolism (APE) in the emergency Department (ED).
  
  
  METHODS
  Subjects were selected from patients admitted to ED with clinically suspected APE. Demographic, anthropometric and serologic data were collected for each patient.
  
  
  RESULTS
  A total of 315 consecutive patients were analyzed, including 150 patients (53.44 ± 15.14 y; 92 men/58 women) in APE group and 165 patients (49.80 ±13.76y; 94 men/71 women) in the control group. MPV in the APE group was significantly higher than in the control group (9.42±1.22 fl vs. 8.04±0.89 fl, p<0.0001). The best cut-off values for MPV when predicting APE in patients with clinically suspected APE presenting at the ED were 8.55 fl (sensitivity 82.2%; specificity 52.3%).
  
  
  CONCLUSIONS
  MPV is a helpful parameter for the diagnosis of APE in ED, for the first time in the literature.
authors.affiliation: Department of Chest Diseases, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Talay
authors.affiliation: Department of Emergency Medicine, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Tarık
authors.initials: T
authors.lastname: Ocak
authors.affiliation: Department of Internal Medicine, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Alcelik
authors.affiliation: Department of Emergency Medicine, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Kurşat
authors.initials: K
authors.lastname: Erkuran
authors.affiliation: Department of Anesthesiology and Reanimation, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Akcan
authors.initials: A
authors.lastname: Akkaya
authors.affiliation: Department of Emergency Medicine, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Duran
authors.affiliation: Department of Anesthesiology and Reanimation, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Demirhan
authors.affiliation: Department of Chest Diseases, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Kar Kurt
authors.affiliation: Department of Chest Diseases, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Asuk
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets / Q000473:pathology*; D003430:Cross-Sectional Studies; D004632:Emergency Medical Services / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods* / Q000706:statistics & numerical data*; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Acute pulmonary embolism; emergency department; mean platelet volume; thrombus