title: Gene interference strategies as a new tool for the treatment of prostate cancer.
abstract: Prostate cancer (PCa) is one of the most common cancer in men. It affects older men and the incidence increases with age; the median age at diagnosis is 67 years. The diagnosis of PCa is essentially based on three tools: digital rectal exam, serum concentration of prostate specific antigen, and transrectal ultrasound-guided biopsy. Currently, the therapeutic treatments of this cancer are different and range from the prostatectomy to hormonal therapy, to radiation therapy, to immunotherapy, and to chemotherapy. However, additional efforts are required in order to find new weapons for the treatment of metastatic setting of disease. The purpose of this review is to highlight new therapeutic strategies based on gene interference; in fact, numerous siRNA and miRNA in the therapeutic treatment of PCa are reported below.
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio, 7, 80138, Naples, Italy.
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Boccellino
authors.forename: Concetta
authors.initials: C
authors.lastname: Alaia
authors.forename: Gabriella
authors.initials: G
authors.lastname: Misso
authors.forename: Alessia Maria
authors.initials: AM
authors.lastname: Cossu
authors.forename: Gaetano
authors.initials: G
authors.lastname: Facchini
authors.forename: Raffaele
authors.initials: R
authors.lastname: Piscitelli
authors.forename: Lucio
authors.initials: L
authors.lastname: Quagliuolo
authors.forename: Michele
authors.initials: M
authors.lastname: Caraglia
mesh_terms: D000368:Aged; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering