title: Gut bacteria and cancer.
abstract: Microbiota on the mucosal surfaces of the gastrointestinal (GI) tract greatly outnumbers the cells in the human body. Effects of antibiotics indicate that GI tract bacteria may be determining the fate of distal cancers. Recent data implicate dysregulated host responses to enteric bacteria leading to cancers in extra-intestinal sites. Together these findings point to novel anti-cancer strategies aimed at promoting GI tract homeostasis.
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States. Electronic address: serdman@mit.edu.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Erdman
authors.affiliation: Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124, Greece.
authors.forename: Theofilos
authors.initials: T
authors.lastname: Poutahidis
mesh_terms: D001419:Bacteria / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000276:immunology; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D009369:Neoplasms / Q000150:complications / Q000382:microbiology*; D009504:Neutrophils / Q000276:immunology
chemical_list: D015850:Interleukin-6
keywords: Breast cancer; Enteric; Immune system; Mammary cancer; Microbes; Neutrophils; Regulatory T cells