title: C-reactive Protein -717A>G and -286C>T>A Gene Polymorphism and Ischemic Stroke.
abstract: BACKGROUND
  Inflammation plays a pivotal role in the formation and progression of ischemic stroke. Recently, more and more epidemiological studies have focused on the association between C-reactive protein (CRP) -717A > G and -286C > T > A genetic polymorphisms and ischemic stroke. However, the findings of these researches are not conclusive.
  
  
  METHODS
  We performed a meta-analysis to determine whether these two polymorphisms are associated with the risk of ischemic stroke. Eligible studies were identified from the database of PubMed, Medline, Embase, Web of Science, CNKI, Weipu, and Wanfang. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.
  
  
  RESULTS
  Four articles were included in our study, including 1926 cases and 2678 controls for -717A > G polymorphism, 652 cases and 1103 controls for -286C > T > A polymorphism. The results of meta-analysis showed that single nucleotide polymorphism (SNP) -717A > G was not significantly associated with the risk of ischemic stroke (GG vs. AA, OR = 1.12, 95% CI = 0.83-1.50, P = 0.207; GG + GA vs. AA, OR = 1.04, 95% CI = 0.93-1.17, P = 0.533; GG vs. GA + AA, OR = 1.10, 95% CI = 0.82-1.47, P = 0.220). Meta-analysis of SNP - 286C > T > A also demonstrated no statistical evidence of a significant association with the risk of ischemic stroke (AA vs. CC, OR = 0.86, 95% CI = 0.59-1.25, P = 0.348; AA vs. CC, OR = 0.92, 95% CI = 0.80-1.06, P = 0.609; AA vs. CC, OR = 0.89, 95% CI = 0.62-1.30, P = 0.374).
  
  
  CONCLUSIONS
  This meta-analysis demonstrated little evidence to support a role of CRP gene -717A > G, -286C > T > A polymorphisms in ischemic stroke predisposition. However, to draw comprehensive and more reliable conclusions, further larger studies are needed to validate the association between CRP gene polymorphisms and ischemic stroke in various ethnic groups.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Pei-Liang
authors.initials: PL
authors.lastname: Geng
authors.forename: Fu-Qin
authors.initials: FQ
authors.lastname: Yan
authors.forename: Tong
authors.initials: T
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Tang
authors.forename: Jing-Chen
authors.initials: JC
authors.lastname: Zheng
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Wu
authors.affiliation: Department of Nanlou Neurology, The General Hospital of PLA, Beijing 100853, China.
authors.forename: Zhen-Fu
authors.initials: ZF
authors.lastname: Wang
mesh_terms: D000483:Alleles; D002545:Brain Ischemia / Q000235:genetics; D002097:C-Reactive Protein / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*
chemical_list: D002097:C-Reactive Protein