title: Resting-state brain connectivity after surgical and behavioral weight loss.
abstract: OBJECTIVE
  Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss.
  
  
  METHODS
  Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss.
  
  
  RESULTS
  Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to postmeal and bariatric patients exhibited decreased connectivity between these regions pre- to postmeal (P(corrected) <0.05).
  
  
  CONCLUSIONS
  Behavioral dieters showed increased connectivity pre- to postmeal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures and increased attention to satiety signals following behavioral diet interventions.
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Lepping
authors.affiliation: Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA.|Children's Mercy Hospital, Kansas City, Missouri, USA.
authors.forename: Amanda S
authors.initials: AS
authors.lastname: Bruce
authors.affiliation: Department of Psychology, University of Missouri, Kansas City, Missouri, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Francisco
authors.affiliation: Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Yeh
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Preventive Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Martin
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Powell
authors.affiliation: Department of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Hancock
authors.affiliation: Minneapolis VA Health Care Center, Minneapolis, Minnesota, USA.
authors.forename: Trisha M
authors.initials: TM
authors.lastname: Patrician
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Florence J
authors.initials: FJ
authors.lastname: Breslin
authors.affiliation: Department of Surgery-General, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Niazy
authors.initials: N
authors.lastname: Selim
authors.affiliation: Center for Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Medicine-Cardiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Donnelly
authors.affiliation: Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Brooks
authors.affiliation: Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, Kansas, USA.|Department of Psychiatry, University of Kansas Medical Center, Kansas City, Kansas, USA.
authors.forename: Cary R
authors.initials: CR
authors.lastname: Savage
authors.affiliation: Laureate Institute for Brain Research, Tulsa, Oklahoma, USA.|Faculty of Community Medicine, University of Tulsa, Tulsa, Oklahoma, USA.
authors.forename: W Kyle
authors.initials: WK
authors.lastname: Simmons
authors.affiliation: Department of Psychology, University of Missouri, Kansas City, Missouri, USA.
authors.forename: Jared M
authors.initials: JM
authors.lastname: Bruce
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D015390:Gastric Bypass / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*