title: Copper-Catalyzed Intramolecular Desymmetric Aryl C-O Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans.
abstract: O-Heterocyclic structures such as 2,3-dihydrobenzofurans are key motifs in many natural compounds and pharmaceuticals. Enantioselective formation of chiral dihydrobenzofurans and analogues was achieved through a copper-catalyzed desymmetrization strategy with a chiral cyclic 1,2-diamine. A broad range of substrates are compatible with this Cu(I)-diamine catalytic system and afford the desired coupling products with chiral tertiary or quaternary carbon centers in high yields and good to excellent enantioselectivities under mild conditions.
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No.190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530 (China).
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Yang
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan Normal University, No. 36 Lushan Road, Changsha, 410081 (China).
authors.forename: Yangyuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No.190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530 (China).
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No.190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, 510530 (China). cai_qian@gibh.ac.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D002839:Chromans; D003300:Copper; C043168:coumaran
keywords: 2,3-dihydrobenzofuran; O-arylation; asymmetric catalysis; copper; desymmetrization