title: Vaccine associated paralytic poliomyelitis cases from children presenting with acute flaccid paralysis in Uganda.
abstract: A retrospective study to identify VAPP cases from the entire Uganda was conducted between January 2003 and December 2011. Eleven of the 106 AFP cases were VAPPs. The VAPP rate ranged from 0 to 3.39 cases per 1,000,000 birth cohorts and the peak was in 2009 when there was scaling up of OPV immunization activities following an importation of wild poliovirus in the country. All the subsequent polio suspect cases since then have been vaccine-associated polio cases. Our data support the strategy to withdraw OPV and introduce IPV progressively in order to mitigate against the paralysis arising from Sabin polioviruses.
authors.affiliation: Uganda Virus Research Institute (UVRI), Entebbe, Uganda.
authors.forename: Mary B
authors.initials: MB
authors.lastname: Nanteza
authors.affiliation: World Health Organization (WHO), Kampala, Uganda.
authors.forename: Annet
authors.initials: A
authors.lastname: Kisakye
authors.affiliation: World Health Organization Regional Office for Africa, Brazzaville, Republic of Congo.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Ota
authors.affiliation: World Health Organization Regional Office for Africa, Brazzaville, Republic of Congo.
authors.forename: Nicksy
authors.initials: N
authors.lastname: Gumede
authors.affiliation: Uganda Virus Research Institute (UVRI), Entebbe, Uganda.
authors.forename: Josephine
authors.initials: J
authors.lastname: Bwogi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D011051:Poliomyelitis / Q000453:epidemiology* / Q000209:etiology* / Q000473:pathology; D017955:Poliovirus / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage* / Q000009:adverse effects*; D015995:Prevalence; D012189:Retrospective Studies; D014454:Uganda / Q000453:epidemiology
chemical_list: D011055:Poliovirus Vaccine, Oral
keywords: OPV; Uganda; adverse event