title: Novel and Efficient Chromium(II)-Mediated Desulfonylation of α-Sulfonyl Ketone.
abstract: A novel and efficient method for the Cr(II)-mediated desulfonylation of α-sulfonyl ketone by a Cr-ligand-Mn system has been developed during the course of process research on Halaven (eribulin mesylate). This reaction is dramatically accelerated in the presence of an appropriate bipyridyl-type ligand. This system is applicable to reduction of α-sulfur-substituted ketones. In addition, a Cr-Cp2ZrCl2-Mn catalytic system is also applicable to desulfonylation of α-sulfonyl ketone.
authors.forename: Kazato
authors.initials: K
authors.lastname: Inanaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Manabu
authors.initials: M
authors.lastname: Kubota
authors.forename: Yuki
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Chiba
authors.forename: Akio
authors.initials: A
authors.lastname: Kayano
authors.forename: Katsuya
authors.initials: K
authors.lastname: Tagami
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D002384:Catalysis; D002857:Chromium / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D008345:Manganese / Q000737:chemistry; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D000095662:Polyether Polyketides
chemical_list: D015082:2,2'-Dipyridyl; D002857:Chromium; D005663:Furans; D007659:Ketones; D008024:Ligands; D008345:Manganese; D013438:Sulfhydryl Compounds; C490954:eribulin; D000095662:Polyether Polyketides