title: Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study.
abstract: We aim to investigate whether decreased interhemispheric functional connectivity exists in patients with type 2 diabetes mellitus (T2DM) by using resting-state functional magnetic resonance imaging (rs-fMRI). In addition, we sought to determine whether interhemispheric functional connectivity deficits associated with cognition and insulin resistance (IR) among T2DM patients. We compared the interhemispheric resting state functional connectivity of 32 T2DM patients and 30 healthy controls using rs-fMRI. Partial correlation coefficients were used to detect the relationship between rs-fMRI information and cognitive or clinical data. Compared with healthy controls, T2DM patients showed bidirectional alteration of functional connectivity in several brain regions. Functional connectivity values in the middle temporal gyrus (MTG) and in the superior frontal gyrus were inversely correlated with Trail Making Test-B score of patients. Notably, insulin resistance (log homeostasis model assessment-IR) negatively correlated with functional connectivity in the MTG of patients. In conclusion, T2DM patients exhibit abnormal interhemispheric functional connectivity in several default mode network regions, particularly in the MTG, and such alteration is associated with IR. Alterations in interhemispheric functional connectivity might contribute to cognitive dysfunction in T2DM patients.
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China ; Center for Functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA 19104, USA.
authors.forename: Wenqing
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wang
authors.affiliation: Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA 19104, USA.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Spaeth
authors.affiliation: Center for Functional Neuroimaging, University of Pennsylvania, 3710 Hamilton Walk, Philadelphia, PA 19104, USA.
authors.forename: Hengyi
authors.initials: H
authors.lastname: Rao
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Wang
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Huang
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Cai
authors.affiliation: Medical School of Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology