title: Static magnetic field exposure-induced oxidative response and caspase-independent apoptosis in rat liver: effect of selenium and vitamin E supplementations.
abstract: In the present study, we investigated the implication of oxidative stress and apoptosis under static magnetic field (SMF) in the brain and liver. Moreover, we estimated the protective role of selenium and vitamin E in rat tissues against disorders induced by SMF. Exposure of rats to SMF (128 mT, 1 h/day during five consecutive days) increased the activity of catalase (CAT) (+24 %) in the liver but not in the brain. By contrast, the same treatment failed to alter malondialdehyde (MDA) concentration in the brain and liver. Exposure to SMF also induced hepatocyte apoptosis through a caspase-independent pathway involving mitochondrial apoptosis-inducing factor (AIF) but not in the brain. Selenium and vitamin E supplementations to SMF-exposed rats restored liver CAT activity but failed to minimize liver apoptosis.
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia. ghodhbanes@yahoo.fr.
authors.forename: Soumaya
authors.initials: S
authors.lastname: Ghodbane
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia.|Institut Supérieur des Sciences Biologiques Appliquées de Tunis, Université de Tunis el Manar, Tunis, Tunisia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ammari
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia.
authors.forename: Aida
authors.initials: A
authors.lastname: Lahbib
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Sakly
authors.affiliation: Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia.
authors.forename: Hafedh
authors.initials: H
authors.lastname: Abdelmelek
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000528:radiation effects*; D020169:Caspases / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements / Q000032:analysis*; D005260:Female; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism* / Q000528:radiation effects*; D060526:Magnetic Fields / Q000009:adverse effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D020169:Caspases; D012643:Selenium
keywords: Apoptosis-inducting factor (AIF); Oxidative stress; Selenium; Static magnetic field; Vitamin E