title: Reactogenicity of trivalent inactivated influenza vaccine in young children: Pronounced reactions by previous successive vaccinations.
abstract: In order to assess factors associated with reactogenicity of trivalent inactivated influenza vaccine (IIV3) among young children, data on 1538 vaccinees aged 0-5 years in a previous vaccine effectiveness study were analyzed. The most frequent reaction was redness (19%), followed by induration, swelling, itching, and pain (6-12%); there were no serious adverse events. For some local reactions, multivariate analyses indicated associations of younger age, preschool attendance, presence of siblings, and allergy with lower risk, and use of thinner needles with higher risk. Most notably, administration of one or more IIV3 vaccines during the previous 3 seasons was positively associated with each local reaction (adjusted odds ratios: 3.6-5.4). For subjects aged ≥3 years, prior successive annual vaccinations were associated with substantially increased local reactions, with clear dose-response relationships (P for trend: <0.001 for each); for example, an 9.8-fold greater risk of swelling following three successive annual vaccinations before the study season.
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan. Electronic address: chikaokda@gmail.com.
authors.forename: Chika
authors.initials: C
authors.lastname: Okada
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Fujieda
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Wakaba
authors.initials: W
authors.lastname: Fukushima
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Ohfuji
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kondo
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Maeda
authors.affiliation: National Mie Hospital, 357 Ozato-Kubota, Tsu, Mie, 514-0125, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
authors.affiliation: Kurume University, 67 Asahi-machi, Kurume-shi, Fukuoka, 830-0011, Japan.
authors.forename: Masaro
authors.initials: M
authors.lastname: Kaji
authors.affiliation: Department of Public Health, Osaka City University Faculty of Medicine, 1-4-3 Asahi-machi, Abeno-ku, , Osaka, 545-8585, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hirota
mesh_terms: D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects*; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D012871:Skin Diseases / Q000139:chemically induced / Q000453:epidemiology / Q000473:pathology
chemical_list: D007252:Influenza Vaccines
keywords: Adverse event; Children; Influenza vaccine; Successive vaccinations