title: The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
abstract: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
authors.forename: Padmaja
authors.initials: P
authors.lastname: Subbarao
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Sonia S
authors.initials: SS
authors.lastname: Anand
authors.affiliation: University of Manitoba, Winnipeg, Canada.
authors.forename: Allan B
authors.initials: AB
authors.lastname: Becker
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: A Dean
authors.initials: AD
authors.lastname: Befus
authors.affiliation: University of British Columbia, Vancouver, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Brauer
authors.affiliation: Environment Canada, Toronto, Canada.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Brook
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Judah A
authors.initials: JA
authors.lastname: Denburg
authors.affiliation: University of Manitoba, Winnipeg, Canada.
authors.forename: Kent T
authors.initials: KT
authors.lastname: HayGlass
authors.affiliation: University of British Columbia, Vancouver, Canada.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kobor
authors.affiliation: University of British Columbia, Vancouver, Canada.
authors.forename: Tobias R
authors.initials: TR
authors.lastname: Kollmann
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: Anita L
authors.initials: AL
authors.lastname: Kozyrskyj
authors.affiliation: University of Toronto, Toronto, Canada.
authors.forename: W Y Wendy
authors.initials: WY
authors.lastname: Lou
authors.affiliation: University of Alberta, Edmonton, Canada.
authors.forename: Piushkumar J
authors.initials: PJ
authors.lastname: Mandhane
authors.affiliation: Northwestern University, Chicago, USA.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Miller
authors.affiliation: Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
authors.forename: Theo J
authors.initials: TJ
authors.lastname: Moraes
authors.affiliation: University of British Columbia, Vancouver, Canada.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Pare
authors.affiliation: University of Toronto, Toronto, Canada.
authors.forename: James A
authors.initials: JA
authors.lastname: Scott
authors.affiliation: Simon Fraser University, Vancouver, Canada.
authors.forename: Tim K
authors.initials: TK
authors.lastname: Takaro
authors.affiliation: University of British Columbia, Vancouver, Canada.
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Turvey
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Duncan
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Lefebvre
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Sears
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000209:etiology*; D002170:Canada; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
keywords: Allergic lung disease; Asthma; Asthma Epidemiology; Asthma Genetics; Asthma Mechanisms; Paediatric asthma; Respiratory Measurement; Viral infection