title: Delays in Manual Reaching Are Associated with Impaired Functional Abilities in Early Dementia Patients.
abstract: OBJECTIVE
  Recent evidence shows that early dementia patients have deficits in manual reaching tasks. It is important to understand the impact of these functional disabilities on their quality of life. The aim of this study was to investigate if there is an association between manual reaching and measures of (instrumental) activities of daily living (IADL) in a group of patients with cognitive complaints.
  
  
  METHODS
  The manual reaching performance of 27 patients was assessed in detail with eye and hand tracking devices. Patients were divided into three groups based on self-reported loss of IADL function. Parameters describing hand response and movement times were compared between groups.
  
  
  RESULTS
  Patients with loss of IADL function in ≥1 domain had delayed hand response and hand movement times towards visible targets compared to patients with no loss of IADL function.
  
  
  CONCLUSIONS
  Delays in manual reaching movements are related to the degree of loss of IADL function in early dementia patients.
authors.affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Casper
authors.initials: C
authors.lastname: de Boer
authors.forename: Johan J M
authors.initials: JJ
authors.lastname: Pel
authors.forename: Johannes
authors.initials: J
authors.lastname: van der Steen
authors.forename: Francesco
authors.initials: F
authors.lastname: Mattace-Raso
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013647:Task Performance and Analysis; D014796:Visual Perception