title: Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.
abstract: Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China.
authors.forename: Li-na
authors.initials: LN
authors.lastname: Niu
authors.affiliation: Wuhan University, Wuhan, PR China.
authors.forename: Hong-ye
authors.initials: HY
authors.lastname: Yang
authors.affiliation: University of Hong Kong, Hong Kong SAR, PR China.
authors.forename: Cynthia K Y
authors.initials: CK
authors.lastname: Yiu
authors.affiliation: Peking University School and Hospital of Stomatology, Beijing, PR China.
authors.forename: Tian-da
authors.initials: TD
authors.lastname: Wang
authors.affiliation: Wuhan University, Wuhan, PR China.
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Zhou
authors.affiliation: Tongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Mao
authors.affiliation: Wuhan University, Wuhan, PR China.
authors.forename: Cui
authors.initials: C
authors.lastname: Huang
authors.affiliation: Georgia Regents University, Augusta, Georgia, 30912-1129, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Pashley
authors.affiliation: Georgia Regents University, Augusta, Georgia, 30912-1129, USA.
authors.forename: Franklin R
authors.initials: FR
authors.lastname: Tay
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000494:pharmacology; D032701:Biomimetics / Q000379:methods*; D001842:Bone and Bones / Q000378:metabolism*; D002130:Calcium Phosphates / Q000494:pharmacology; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism*; D003460:Crystallization / Q000379:methods*; D003692:Delayed-Action Preparations / Q000494:pharmacology; D004337:Drug Carriers / Q000494:pharmacology*; D053758:Nanoparticles; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000494:pharmacology; D014089:Tooth Remineralization
chemical_list: D002130:Calcium Phosphates; D024042:Collagen Type I; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C519480:amorphous calcium phosphate; D012822:Silicon Dioxide