title: Survival of childhood acute lymphoid leukaemia in Yorkshire by clinical trial era, 1990-2011.
abstract: Gender-specific differences in survival by clinical trial era in Yorkshire were assessed for children with acute lymphoid leukaemia (ALL) enrolled onto UKALLXI, ALL97/99 or UKALL2003 (n = 630; 1990-2011). For males, there was a non-significant improvement in survival for ALL97/99 [hazard ratio (HR) = 0·77; 95% confidence interval (CI) 0·43-1·42) and a significant improvement for UKALL2003 (HR = 0·50; 95%CI 0·25-0·99) compared to UKALLXI. For females, survival was significantly improved for ALL97/99 (HR = 0·33; 95%CI 0·14-0·78), and non-significantly improved for UKALL2003 (HR = 0·51; 95%CI 0·25-1·08) compared to UKALLXI. Modest overall survival improvements masked clinically important gender-specific changes over time by trial era, requiring confirmation in larger population-based studies.
authors.affiliation: Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK.
authors.forename: Marlous
authors.initials: M
authors.lastname: van Laar
authors.affiliation: Regional Department of Paediatric Oncology and Haematology, Leeds, UK.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Kinsey
authors.affiliation: Division of Epidemiology and Biostatistics, School of Medicine, University of Leeds, Leeds, UK.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Feltbower
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D012727:Sex Characteristics; D015996:Survival Rate; D006113:United Kingdom / Q000453:epidemiology
keywords: acute lymphoid leukaemia; clinical trial; paediatric; survival