title: Neurocognitive outcomes after extracorporeal membrane oxygenation.
abstract: Extracorporeal membrane oxygenation (ECMO) has been a therapy of last resort for the treatment of severe cardiorespiratory failure since the 1970s [1]. In recent years, ECMO has seen a resurgence in its use in adults. Recent work examining rates of ECMO use in the US adult population, using Nationwide Inpatient Sample data, quotes an increase in use of 433% from 2006 to 2011 [2]. While much research has focused on neurologic injury after cardiac surgery and cardiopulmonary bypass (CPB), the effects of ECMO on neurocognitive function are less well described. This review aims to summarize recent findings as they pertain to pathophysiology, monitoring techniques, prevention, therapy, and emerging experimental concepts in the context of ECMO for adult patients. Given that neurocognitive outcomes after cardiac surgery have been recently reviewed [3,4], we will limit the discussion of findings from the cardiac surgery/CPB literature to those especially relevant for ECMO.
authors.affiliation: Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Lyndsey C
authors.initials: LC
authors.lastname: Graber
authors.affiliation: Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Nidia
authors.initials: N
authors.lastname: Quillinan
authors.affiliation: Department of Neurology, Duke University, Durham, NC, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Marrotte
authors.affiliation: Department of Anesthesiology and Pain Management, UT Southwestern, Dallas, TX, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: McDonagh
authors.affiliation: Department of Anesthesiology, University of Colorado Denver, Aurora, CO, USA. Electronic address: karsten.bartels@ucdenver.edu.
authors.forename: Karsten
authors.initials: K
authors.lastname: Bartels
mesh_terms: D000818:Animals; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000639:trends; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects* / Q000639:trends; D006801:Humans; D016343:Monitoring, Intraoperative / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D016896:Treatment Outcome
keywords: ECMO; neurocognitive dysfunction; neuroprotection; stroke