title: Anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma with involvement of the urinary bladder: a case report and review of literature.
abstract: We report a unique case of anaplastic large-cell lymphoma (ALCL) involving the urinary bladder in a 22-year-old man. The patient presented with left lower back pain for 4 weeks. The computed tomography (CT) scan demonstrated an exophytic nodule on the left bladder wall and abdominopelvic lymphadenopathy. Histologically, a population of large pleomorphic cells extensively infiltrated the lamina propria of the bladder. These cells were diffusely and strongly immunoreactive for CD30, ALK, EMA, and vimentin, but were negative for AE1/AE3, CK20, CK7, CK5/6, P63, SMA, HMB-45, pan-Melan, S-100, Myo D1, synaptophysin, CD56, desmin, CD15, CD20, Pax-5, and CD3. Few cells exhibited positive immunohistochemical staining of CD45. The patient underwent cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regime of chemotherapy and achieved a complete remission after four cycles. This case is the tenth documented case of systemic ALCL involving urinary bladder. Due to its rarity, it is important to be aware of the features of ALCL in bladder, and make prompt and accurate diagnosis.
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China ; Department of Pathology, Gansu Provincial People's Hospital, Lanzhou, Gansu, People's Republic of China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Yingmei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Jinsong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Department of Pathology, Gansu Provincial People's Hospital, Lanzhou, Gansu, People's Republic of China.
authors.forename: Jinsui
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, Gansu Provincial People's Hospital, Lanzhou, Gansu, People's Republic of China.
authors.forename: Yamei
authors.initials: Y
authors.lastname: Dang
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China ; Department of Neurosurgery, First affiliated Hospital, China Medical University, Shenyang, Liaoning, People's Republic of China.
authors.forename: Haomin
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Ru
authors.initials: R
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Tumor Biology, Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Qiao
keywords: anaplastic large-cell lymphoma; anaplastic lymphoma kinase; urinary bladder