title: Asbestos exposure increases the incidence of histologically confirmed usual interstitial pneumonia.
abstract: OBJECTIVE
  We hypothesized that asbestos exposure increases the incidence of macroscopically visible and histologically confirmed usual interstitial pneumonia (histological UIP).
  
  
  RESULTS
  We retrospectively examined 1718 cases (1202 males; mean age 66.7 years) who underwent lobectomy for resection of pleuropulmonary tumours. Objective markers for asbestos exposure included: the presence of malignant pleural mesothelioma, the presence of pleural plaques (PPs) and asbestos bodies in the histological specimen. Risk factors for histological UIP were examined. Two separate groups were studied: 183 with asbestos exposure, and 239 with histological UIP. The 183 cases with asbestos exposure had higher rates of positive occupational history and histological UIP (31%) than the remaining 1535. Among the asbestos-exposed group, small numbers of asbestos bodies were found in histological specimens of 21 cases of histological UIP. PPs and asbestos bodies were more frequent in the 239 patients with histological UIP than in the remaining 1479 UIP-negative patients. Multivariate analysis showed that asbestos exposure, especially positivity for asbestos bodies, that does not meet the current criteria for asbestosis increases the risk of histological UIP (P < 0.0001).
  
  
  CONCLUSIONS
  Asbestos exposure causes asbestosis and increases the incidence of histological UIP.
authors.affiliation: Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
authors.affiliation: Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.affiliation: Department of Thoracic Surgery, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Eishin
authors.initials: E
authors.lastname: Hoshi
authors.affiliation: Department of Thoracic Surgery, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Murai
authors.affiliation: Department of Radiology, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Tetsu
authors.initials: T
authors.lastname: Kanauchi
authors.affiliation: Department of Pulmonary Medicine, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kurashima
authors.affiliation: Department of Pulmonary Medicine, Saitama Prefectural Cardiovascular and Respiratory Centre, Kumagaya city, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
mesh_terms: D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D001195:Asbestosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D008297:Male; D008654:Mesothelioma / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D010995:Pleural Diseases / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D010997:Pleural Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001194:Asbestos
keywords: asbestos exposure; malignant pleural mesothelioma; pleural plaque; usual interstitial pneumonia