title: Nanoparticle-based lateral flow biosensors.
abstract: Lateral flow biosensors (LFBs) are paper-based devices which permit the performance of low-cost and fast diagnostics with good robustness, specificity, sensitivity and low limits of detection. The use of nanoparticles (NPs) as labels play an important role in the design and fabrication of a lateral flow strip (LFS). The choice of NPs and the corresponding detection method directly affect the performance of these devices. This review discusses aspects related to the application of different nanomaterials (e.g. gold nanoparticles, carbon nanotubes, quantum dots, up-converting phosphor technologies, and latex beads, between others) in LFBs. Moreover, different detection methods (colorimetric, fluorescent, electrochemical, magnetic, etc.) and signal enhancement strategies (affording secondary reactions or modifying the architecture of the LFS) as well as the use of devices such as smartphones to mediate the response of LFSs will be analyzed.
authors.affiliation: Nanobioelectronics & Biosensors Group, Institut Català de Nanociència i Nanotecnologia (ICN2), Campus UAB, 08193 Bellaterra, Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Quesada-González
authors.affiliation: Nanobioelectronics & Biosensors Group, Institut Català de Nanociència i Nanotecnologia (ICN2), Campus UAB, 08193 Bellaterra, Barcelona, Spain; ICREA, Institució Catalana de Recerca i Estudis Avançats, Barcelona 08010, Spain. Electronic address: arben.merkoci@icn.cat.
authors.forename: Arben
authors.initials: A
authors.lastname: Merkoçi
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation*; D002244:Carbon; D004396:Coloring Agents; D055664:Electrochemical Techniques / Q000295:instrumentation; D005456:Fluorescent Dyes; D006046:Gold; D006801:Humans; D008081:Liposomes; D058185:Magnetite Nanoparticles; D053768:Metal Nanoparticles; D053758:Nanoparticles; D045663:Quantum Dots
chemical_list: D004396:Coloring Agents; D005456:Fluorescent Dyes; D008081:Liposomes; D058185:Magnetite Nanoparticles; D002244:Carbon; D006046:Gold
keywords: Electrochemical detection; Immunoassay; Lateral flow; Nanoparticle; Optical detection