title: The Relationship Between Serum Levels of Interleukins 6, 8, 10 and Clinical Outcome in Patients With Severe Traumatic Brain Injury.
abstract: BACKGROUND
  Clinical outcome in patients with severe traumatic brain injury (TBI) depends on both primary and secondary brain injuries. Neuroinflammation is an important secondary mechanism, which occurs by releasing interleukins (ILs). Increased levels of ILs may affect clinical outcome following TBI.
  
  
  OBJECTIVE
  This study aimed to determine the relationship between the serum levels of interleukins 6, 8 and 10 and clinical outcome in patients with severe TBI 6 months after injury.
  
  
  METHODS
  In a descriptive-analytical study, 44 patients with GCS ≤ 8 (Glasgow coma scale) and age ≥ 14 years were included. Their blood samples were collected at first 6 hours after injury. Clinical outcome was determined based on GOS (Glasgow Outcome Scale) at 6 months after head injury. Serum levels of interleukins 6, 8 and 10 were measured using the ELISA method. Spearman's rho, independent T-Test, and Mann-Whitney Test were used for data analysis.
  
  
  RESULTS
  Comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 31.9, respectively lower than those of group with unfavorable outcome with 162.3 ± 141.1 and 173.6 ± 257.3 (P < 0.03) and (P < 0.01).
  
  
  CONCLUSIONS
  Increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe TBI.
authors.affiliation: Neurosurgery Department, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Sharhokh
authors.initials: S
authors.lastname: Yousefzadeh-Chabok
authors.affiliation: Anesthesiology Department, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Anoush
authors.initials: A
authors.lastname: Dehnadi Moghaddam
authors.affiliation: Biostatistics Department,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Kazemnejad-Leili
authors.affiliation: Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Saneei
authors.affiliation: Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Marieh
authors.initials: M
authors.lastname: Hosseinpour
authors.affiliation: Human Resource Management, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Kouchakinejad-Eramsadati
authors.affiliation: Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Razzaghi
authors.affiliation: Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, IR Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mohtasham-Amiri
keywords: Brain; Head Injury; Interleukin