title: Prognostic significance of matrix metalloproteinase 7 immunohistochemical expression in colorectal cancer: a meta-analysis.
abstract: Matrix metalloproteinase 7 (MMP-7) was speculated to have a key role in the development and progression of human cancer. Considerable studies investigated the relationship between its expression and survival in colorectal cancer (CRC), but inconsistent results were obtained. The clinical significance of MMP-7 overexpression in CRC remains controversial. Therefore, in this article, we conducted a meta-analysis to analyze the prognostic value of MMP-7 in CRC. We searched studies in PubMed, Medline, and Web of Science databases until August 2014 to find relevant studies. A total of six high-quality studies met the inclusion criteria and 1631 patients were included in our study. Combined hazard ratios (HRs) suggested that MMP-7 overexpression had an unfavorable impact on overall survival (HR = 1.83, 95% CI: 1.24-2.71). Subgroup and sensitivity analyses further validated the role of MMP-7 as a predictor for prognosis. In conclusion, MMP-7 overexpression detected by immunohistochemistry indicated worse prognosis in CRC and may help to guide clinical therapy.
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chen
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Yeting
authors.initials: Y
authors.lastname: Hu
authors.affiliation: School of Finance, Zhejiang University of Finance and Economics Hangzhou, Zhejiang, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Xiang
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Cai
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Zhanhuai
authors.initials: Z
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.affiliation: The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute Hangzhou, Zhejiang, China ; Second Affiliated Hospital of Zhejiang University, School of Medicine Hangzhou, Zhejiang, China.
authors.forename: Kefeng
authors.initials: K
authors.lastname: Ding
keywords: Matrix metalloproteinase 7; colorectal cancer; meta-analysis; prognosis