title: Enhanced biocompatibility and adhesive properties of modified allyl 2-cyanoacrylate-based elastic bio-glues.
abstract: Despite cyanoacrylate's numerous advantages such as good cosmetic results and fast application for first aid, drawbacks such as brittleness and local tissue toxicity have limited their applicability. In this study, to improve both the biocompatibility and mechanical properties of cyanoacrylate, allyl 2-cyanoacrylate (AC) was pre-polymerized and mixed with poly(L-lactide-co-ɛ-caprolactone) (PLCL, 50:50) as biodegradable elastomer. For various properties of pre-polymerized AC (PAC)/PLCL mixtures, bond strength, elasticity of flexure test as bending recovery, cell viability, and in vivo test using rat were conducted and enhanced mechanical properties and biocompatibility were confirmed. Especially, optimal condition for pre-polymerization of AC was determined to 150°C for 40min through cytotoxicity test. Bond strength of PAC/PLCL mixture was decreased (over 10 times) with increasing of PLCL. On the other hand, biocompatibility and flexibility were improved than commercial bio-glue. Optimal PAC/PLCL composition (4g/20mg) was determined through these tests. Furthermore, harmful side effects and infection were not observed by in vivo wound healing test. These results indicate that PAC/PLCL materials can be used widely as advanced bio-glues in various fields.
authors.affiliation: Laboratory of Biointerfaces/Tissue Engineering, Department of Chemical Engineering, Institute of Tissue Regeneration Engineering, College of Engineering, Dankook University, Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701, Republic of Korea.
authors.forename: Jin Ik
authors.initials: JI
authors.lastname: Lim
authors.affiliation: Division of Biomedical Polymer Development Center, JISAN Co., Seoul 130-707, Republic of Korea. Electronic address: love3010@naver.com.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D003487:Cyanoacrylates / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014014:Tissue Adhesives
chemical_list: D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives
keywords: Ally 2-cyanoacrylate; Bio-glue; Biocompatibility; Bond strength; Flexibility; Wound healing