title: A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity.
abstract: OBJECTIVE
  To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity.
  
  
  METHODS
  We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks.
  
  
  RESULTS
  Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients.
  
  
  CONCLUSIONS
  Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide.
authors.affiliation: Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Urology, Sakai-Onshinkai Hospital, Sakai, Osaka, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Akiyama
authors.affiliation: Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Shimizu
authors.affiliation: Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumura
authors.affiliation: Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan.
authors.forename: Taiji
authors.initials: T
authors.lastname: Hayashi
authors.affiliation: Department of Urology, Sakai Hospital, Kinki University Faculty of Medicine, Sakai, Osaka, Japan.
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Nishioka
authors.affiliation: Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Uemura
keywords: acotiamide hydrochloride hydrate; detrusor underactive; distigmine bromide; underactive bladder