title: Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones.
abstract: Obesity is on the rise and the pursuit of efficient and safe treatment is ongoing. Available anti-obesity medical therapies have so far proved to be disappointing, whereas bariatric surgery is leading the way and offers long-term health benefits. Part of the success of bariatric surgery is thought to be mediated by gut hormones. A better understanding of the role of gut hormones within the gut-brain signaling pathway in the control of hunger, satiety, and energy homeostasis, has led to their therapeutic exploitation as possible anti-obesity drugs. In this review, we provide a summary of currently available treatment options for obesity from simple lifestyle modifications and bariatric surgery to traditional and novel medical therapies.
authors.affiliation: Division of Diabetes, Endocrinology and Metabolism, Hammersmith Hospital, Imperial College London , Du Cane Road, London , UK.
authors.forename: Preeshila
authors.initials: P
authors.lastname: Behary
authors.forename: Jaimini
authors.initials: J
authors.lastname: Cegla
authors.forename: Tricia M
authors.initials: TM
authors.lastname: Tan
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Bloom
mesh_terms: D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D050110:Bariatric Surgery; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006801:Humans; D008019:Life Style; D009765:Obesity / Q000628:therapy*
chemical_list: D019440:Anti-Obesity Agents; D005768:Gastrointestinal Hormones
keywords: Obesity; bariatric surgery; drugs; gut hormones; lifestyle management