title: MicroRNAs as Regulator of Signaling Networks in Metastatic Colon Cancer.
abstract: MicroRNAs (miRNAs) are a class of small, noncoding RNA molecules capable of regulating gene expression translationally and/or transcriptionally. A large number of evidence have demonstrated that miRNAs have a functional role in both physiological and pathological processes by regulating the expression of their target genes. Recently, the functionalities of miRNAs in the initiation, progression, angiogenesis, metastasis, and chemoresistance of tumors have gained increasing attentions. Particularly, the alteration of miRNA profiles has been correlated with the transformation and metastasis of various cancers, including colon cancer. This paper reports the latest findings on miRNAs involved in different signaling networks leading to colon cancer metastasis, mainly focusing on miRNA profiling and their roles in PTEN/PI3K, EGFR, TGFβ, and p53 signaling pathways of metastatic colon cancer. The potential of miRNAs used as biomarkers in the diagnosis, prognosis, and therapeutic targets in colon cancer is also discussed.
authors.affiliation: Human Stem Cell Institute of the General Hospital, Ningxia Medical University, Yinchuan 750004, China ; Department of Colorectal Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Human Stem Cell Institute of the General Hospital, Ningxia Medical University, Yinchuan 750004, China ; Department of Colorectal Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Du
authors.affiliation: Human Stem Cell Institute of the General Hospital, Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: William C
authors.initials: WC
authors.lastname: Cho
authors.affiliation: Human Stem Cell Institute of the General Hospital, Ningxia Medical University, Yinchuan 750004, China ; Department of Colorectal Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yinxue
authors.initials: Y
authors.lastname: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D011379:Prognosis; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D019869:Phosphatidylinositol 3-Kinases