title: A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability.
abstract: A novel azopyridine-based Ru(II) complex [Ru(bpy)2(L1)2](2+) (bpy = 2,2'-bipyridine, L1 = 4,4'-azopyridine) was designed and synthesized as a potential glutathione (GSH)-responsive photoactivated chemotherapy (PACT) agent, the DNA covalent binding capability of which can only be activated after GSH reduction and visible light irradiation.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. xswang@mail.ipc.ac.cn zhouqianxiong@mail.ipc.ac.cn.
authors.forename: Qian-Xiong
authors.initials: QX
authors.lastname: Zhou
authors.forename: Yue
authors.initials: Y
authors.lastname: Zheng
authors.forename: Tian-Ji
authors.initials: TJ
authors.lastname: Wang
authors.forename: Yong-Jie
authors.initials: YJ
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Li
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Yuan-Jun
authors.initials: YJ
authors.lastname: Hou
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Wang
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D008027:Light; D010084:Oxidation-Reduction; D011789:Quantum Theory; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D015082:2,2'-Dipyridyl; D012428:Ruthenium; D004247:DNA; D005978:Glutathione