title: Macro- and microvascular disease in systemic sclerosis.
abstract: Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a direct target of the disease. In this review, we present the various clinical manifestations of the vasculopathy that can be present in SSc patients, and then discuss the various aspects of the pathophysiology of the vascular disorders.
authors.affiliation: Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, INSERM U 1016, Institut Cochin, Paris, France; Laboratoire d'immunologie biologique, Hôpital Cochin, Groupe Hospitalier Paris Centre, AP-HP, 75679 Paris cedex 14, France. Electronic address: niloufar.kavian@cch.aphp.fr.
authors.forename: Niloufar
authors.initials: N
authors.lastname: Kavian
authors.affiliation: Faculté de Médecine Paris Descartes, Sorbonne Paris Cité, INSERM U 1016, Institut Cochin, Paris, France; Laboratoire d'immunologie biologique, Hôpital Cochin, Groupe Hospitalier Paris Centre, AP-HP, 75679 Paris cedex 14, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Batteux
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D055806:Microvessels / Q000378:metabolism / Q000473:pathology*; D015539:Platelet Activation / Q000502:physiology; D012595:Scleroderma, Systemic / Q000378:metabolism / Q000473:pathology*; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology*
keywords: Angiogenesis; Endo-mesenchymal transistion; Endothelial cells; Pericytes; Reactive oxygen species; Systemic sclerosis; Vasculogenesis; Vasculopathy