title: Management of diabetic complications through fruit flavonoids as a natural remedy.
abstract: Diabetes mellitus is a global disorder, and a major issue for health care systems. The current review outlooks the use of fruit flavonoids as natural remedy in the prevention of diabetes mellitus. The onset of diabetes mainly depends upon genetics and lifestyle issues. Currently used therapeutic options for the control of diabetes, like dietary amendments, oral hypoglycemic drugs, and insulin, have their own limitations. Fruit flavonoids possess various antidiabetic, anti-inflammatory, and antioxidant potentials and act on various cellular signaling pathways in pancreas, white adipose tissue, skeletal muscle, and liver function, which in result induces antidiabetic effects. Recently, antidiabetic effect of fruit flavonoids has been studied using various animal models and clinical trials. Research studies revealed a statistically significant potential of fruit flavonoids in managing the altered glucose and oxidative metabolisms in diabetes. Unlike synthetic antidiabetic agents, fruit flavonoids manage diabetes without compromising cellular homeostasis thereby posing no side effects. Further studies are required in purification and characterization of different fruit flavonoids with respect to their beneficial effect for diabetic patients.
authors.affiliation: a Institute of Food Science and Nutrition, University of Sargodha , Sargodha , Pakistan.
authors.forename: Amna
authors.initials: A
authors.lastname: Tanveer
authors.affiliation: a Institute of Food Science and Nutrition, University of Sargodha , Sargodha , Pakistan.
authors.forename: Kashif
authors.initials: K
authors.lastname: Akram
authors.affiliation: a Institute of Food Science and Nutrition, University of Sargodha , Sargodha , Pakistan.
authors.forename: Umar
authors.initials: U
authors.lastname: Farooq
authors.affiliation: b Department of Animal Sciences , University College of Agriculture, University of Sargodha , Sargodha , Pakistan.
authors.forename: Zafar
authors.initials: Z
authors.lastname: Hayat
authors.affiliation: a Institute of Food Science and Nutrition, University of Sargodha , Sargodha , Pakistan.
authors.forename: Afshan
authors.initials: A
authors.lastname: Shafi
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001682:Biological Availability; D029441:Carica / Q000737:chemistry; D002957:Citrus / Q000737:chemistry; D048909:Diabetes Complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D029788:Diospyros / Q000737:chemistry; D004195:Disease Models, Animal; D005419:Flavonoids / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D031647:Psidium / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts
keywords: Diabetes mellitus; antidiabetic effect; flavonoids; fruits