title: Articular Cartilage Repair: Where We Have Been, Where We Are Now, and Where We Are Headed.
abstract: This review traces the genealogy of the field of articular cartilage repair from its earliest attempts to its present day vast proliferation of research advances. Prior to the 1980s there was only sporadic efforts to regenerate articular cartilage as it was considered to be incapable of regeneration based on historical dogma. The first flurry of reports documented the use of various cell types ultimately leading to the first successful demonstration of autologous chondrocyte transplantation which was later translated to clinical use and has resulted in the revised axiom that cartilage regeneration is possible. The current field of cartilage repair is multifaceted and some of the 1980s' vintage concepts have been revisited with state of the art technology now available. The future of the field is now poised to undertake the repair of whole cartilage surfaces beyond focal defects and an appreciation for integrated whole joint health to restore cartilage homeostasis.
authors.affiliation: Department of Orthopaedic Surgery, Feinstein Institute for Medical Research, North Shore-LIJ Health Systems, Manhasset, NY, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Grande
authors.affiliation: Department of Orthopaedic Surgery, Feinstein Institute for Medical Research, North Shore-LIJ Health Systems, Manhasset, NY, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Schwartz
authors.affiliation: Department of Orthopaedic Surgery, Feinstein Institute for Medical Research, North Shore-LIJ Health Systems, Manhasset, NY, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Brandel
authors.affiliation: Department of Orthopaedic Surgery, Feinstein Institute for Medical Research, North Shore-LIJ Health Systems, Manhasset, NY, USA.
authors.forename: Nadeen O
authors.initials: NO
authors.lastname: Chahine
authors.affiliation: Department of Orthopaedic Surgery, Feinstein Institute for Medical Research, North Shore-LIJ Health Systems, Manhasset, NY, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Sgaglione
keywords: articular cartilage; cells; chondrocytes; diagnosis; osteoarthritis; tissue