title: Bordetella holmesii infection: current knowledge and a vision for future research.
abstract: Bordetella holmesii is a recently recognized Gram-negative bacterium causing both pertussis-like respiratory symptoms and invasive infections, such as bacteremia, pneumonia, meningitis, arthritis, pericarditis and endocarditis. Few data are available on its epidemiological characteristics, mostly related to respiratory infections. However, these are frequently misdiagnosed as a Bordetella pertussis infection as most diagnostic tests routinely used are not species-specific, thus biasing the epidemiological studies of both strains, as well as the efficacy studies on pertussis vaccination. There is no accepted agreement on treatment and it remains unknown if antimicrobial prophylaxis is indicated in certain clinical settings. We review here the current knowledge on B. holmesii and the need for further research.
authors.affiliation: Department of Pediatrics, Division of General Paediatrics, Children's Hospital, University Hospitals of Geneva, 6 Rue Willy-Donzé, 1211 Geneva 14, Switzerland.
authors.forename: Laure F
authors.initials: LF
authors.lastname: Pittet
authors.forename: Klara M
authors.initials: KM
authors.lastname: Posfay-Barbe
mesh_terms: D001884:Bordetella / Q000235:genetics / Q000502:physiology*; D001885:Bordetella Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D006801:Humans
keywords: 16S ribosomal RNA sequencing; Bordetella holmesii; Bordetella pertussis; Bordetella-specific polymerase chain reaction; arthritis; bacteremia; bhoE; cellulitis; endocarditis; epidemiology; hIS1001; insertion sequences IS481; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; meningitis; pericarditis; pertussis-like illness; pneumonia; recA; vaccination