title: Persistent Bacillus Calmette-Guerin Reaction: A Potential Clue to Underlying Immune Deficiency.
abstract: Bacillus Calmette-Guerin (BCG) vaccine complications in patients with severe combined immunodeficiency (SCID) have been well documented in the literature. We present a case in which the BCG vaccine was administered to an infant who was later diagnosed with SCID and presented with worsening localized BCG reaction upon arrival in the United States. Although the BCG vaccine is not routinely administered in the United States, it is important for physicians to be aware of potential complications of BCG vaccination since prompt treatment can be lifesaving.
authors.affiliation: College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.
authors.forename: Amrit
authors.initials: A
authors.lastname: Khalsa
authors.affiliation: Division of Dermatopathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Adam I
authors.initials: AI
authors.lastname: Rubin
authors.affiliation: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Section of Pediatric Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Melinda
authors.initials: M
authors.lastname: Jen
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects* / Q000276:immunology; D001707:Biopsy, Needle; D057210:Delayed Diagnosis; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008297:Male; D018570:Risk Assessment; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D014376:Tuberculosis / Q000517:prevention & control*; D014479:United Arab Emirates; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D001500:BCG Vaccine