title: Small molecules with big effects: Cyclic di-GMP-mediated stimulation of cellulose production by the amino acid ʟ-arginine.
abstract: In this issue of Science Signaling, Mills et al. show that the amino acid ʟ-arginine increases the concentration of the second messenger c-di-GMP in Salmonella enterica serovar Typhimurium through a specific diguanylate cyclase, leading to increased production of the exopolysaccharide cellulose, which is an extracellular matrix component of environmental and host-associated biofilms.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden. ute.romling@ki.se.
authors.forename: Ute
authors.initials: U
authors.lastname: Römling
mesh_terms: D001120:Arginine / Q000378:metabolism*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D019897:Periplasm / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C062025:bis(3',5')-cyclic diguanylic acid; D001120:Arginine; D006152:Cyclic GMP