title: [Synthesis of new analogues of combretastatin A-4 and the study of their anti-inflammatory activity].
abstract: New approach to synthesis of analogs of natural Combretastatin A-4 based on interaction of α-acetylenic ketones with secondary amines (diethyl amine, pyrrolidine, piperidine, morpholine) is offered. Unknown analogs of Combretastatin A-4 with β-aminovinylcarbonyl bridges are received earlier. Anti-inflammatory activity of the received connections is studied.
authors.forename: M P
authors.initials: MP
authors.lastname: Davydova
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: V I
authors.initials: VI
authors.lastname: Mamatyuk
authors.forename: D S
authors.initials: DS
authors.lastname: Fadeev
authors.forename: S F
authors.initials: SF
authors.lastname: Vasilevsky
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes; C058728:fosbretabulin