title: Anthelmintic activity of ginger, curcumin, and praziquentel against Raillietina cesticillus (in vitro and in vivo).
abstract: This work evaluates the anthelminitic activity of ginger and curcumin on the cestode Raillietina cesticillus. Live parasites were collected from intestine of naturally infected chickens in PBS 0.9 % and then incubated at 37 °C in media containing ginger extract at three different concentrations (125, 250, and 500 mg); every concentration was dissolved in 10 ml media. The curcumin extract was used at three different concentrations (250, 500, and 1000 mg); each was dissolved in 10 ml media. Praziquantel at a concentration of 600 mg was added to 10 ml media. A control one without extract was reported. Regression of worms increased gradually in all concentrations. At 500 mg ginger (50 ± 0 %), worms were regressed at 48 h post-exposure (h.p.e.). Also (50 ± 1.8 %), worms were regressed at 1000 mg curcumin at the same time. On the other hand, praziquantel showed the highest regression (65 ± 2.3 %). The extract efficacy was exhibit as concentration-time-dependent mainly at higher concentrations used after 48 h. In vivo effects of ginger and curcumin were lower than those in vitro.
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, Sadat City University, Sadat City, Egypt.
authors.forename: Nasr M
authors.initials: NM
authors.lastname: El-Bahy
authors.forename: Eman K A
authors.initials: EK
authors.lastname: Bazh
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology*; D002589:Cestoda / Q000187:drug effects* / Q000254:growth & development; D002590:Cestode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D002645:Chickens / Q000469:parasitology; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D011223:Praziquantel / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts; D011223:Praziquantel; D003474:Curcumin