title: Mesenchymal stem cells for sweat gland regeneration after burns: From possibility to reality.
abstract: Sweat glands play important roles in homeostasis maintenance and body temperature regulation. In patients with deep burns, the injury can reach the muscle tissues and damage sweat glands. However, the plasticity of mesenchymal stem cells (MSCs) may offer the possibility to regenerate sweat glands after severe burn. In particular, recent studies have changed the possibility to reality. Here, we analyze the barriers of sweat gland regeneration in situ after deep burns, propose the possibilities of MSCs in regeneration of sweat glands, summarize the recent researches into sweat gland regeneration with MSCs, and sum up the possible mechanisms during this process. In addition, the advantage and disadvantage of sweat gland regeneration with MSCs from different tissues have been discussed. So this review will provide meaningful guidance in the clinic for sweat gland regeneration with MSCs.
authors.affiliation: Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, PR China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ma
authors.affiliation: Tianjin Medical University, Tianjin, PR China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Tan
authors.affiliation: Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, PR China. Electronic address: zcp666666@sohu.com.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key Research Laboratory of Tissue Repair and Regeneration of PLA, and Beijing Key Research Laboratory of Skin Injury, Repair and Regeneration, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing, PR China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fu
mesh_terms: D001854:Bone Marrow Cells; D002056:Burns / Q000628:therapy*; D054338:Cell Transdifferentiation; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012038:Regeneration; D013545:Sweat Glands / Q000502:physiology*
keywords: Burns; Mesenchymal stem cells; Regenerative medicine; Sweat glands; Transdifferentiation