title: Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL.
abstract: Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating.
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. julia.matena@tiho-hannover.de.
authors.forename: Julia
authors.initials: J
authors.lastname: Matena
authors.affiliation: Faculty of Engineering and Computer Science, Osnabrueck University of Applied Sciences, D-49076 Osnabrueck, Germany. s.petersen@hs-osnabrueck.de.
authors.forename: Svea
authors.initials: S
authors.lastname: Petersen
authors.affiliation: Institute for Biomedical Engineering, Rostock University Medical Center, D-18119 Rostock, Germany. m.gieseke@lzh.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Gieseke
authors.affiliation: Materials and Processes Department, Laser Zentrum Hannover e.V., D-30419 Hannover, Germany. michael.teske@uni-rostock.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Teske
authors.affiliation: Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. martin.beyerbach@tiho-hannover.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Beyerbach
authors.affiliation: Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, D-30625 Hannover, Germany. kampmann.andreas@mh-hannover.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kampmann
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. hugo.murua.escobar@med.uni-rostock.|Division of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, University of Rostock, D-18057 Rostock, Germany. hugo.murua.escobar@med.uni-rostock.
authors.forename: Hugo
authors.initials: H
authors.lastname: Murua Escobar
authors.affiliation: Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, D-30625 Hannover, Germany. gellrich.nils-claudius@mh-hannover.de.
authors.forename: Nils-Claudius
authors.initials: NC
authors.lastname: Gellrich
authors.affiliation: Institut fuer Werkstoffkunde, Leibniz Universitaet Hannover, D-30823 Hannover, Germany. haferkamp@iw.uni-hannover.de.
authors.forename: Heinz
authors.initials: H
authors.lastname: Haferkamp
authors.affiliation: Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany. ingo.nolte@tiho-hannover.de.
authors.forename: Ingo
authors.initials: I
authors.lastname: Nolte
mesh_terms: D000818:Animals; D000069343:Bone-Implant Interface; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000009:adverse effects* / Q000737:chemistry; D007834:Lasers; D008274:Magnesium / Q000009:adverse effects / Q000737:chemistry*; D051379:Mice; D016348:Osseointegration; D011091:Polyesters / Q000737:chemistry*; D014025:Titanium / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C016240:polycaprolactone; D014025:Titanium; D008274:Magnesium
keywords: live cell imaging; magnesium implant; osteoblast; poly-3-hydroxybutyrate; polycaprolactone; titanium implant