title: Obsessive-compulsive symptom severity in schizophrenia: a Janus Bifrons effect on functioning.
abstract: The impact of obsessive-compulsive symptoms on functioning in schizophrenia is still debated. This study investigated the relationship between OC symptoms and functioning along a severity gradient of obsessive-compulsive dimension. Sixty patients affected by schizophrenia completed the SCID-IV, the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale and the Social and Occupational Functioning Assessment Scale. The relationship between functioning and obsessive-compulsive dimension was described by a reverse U-shaped curve; functioning was positively related to the presence of mild obsessive-compulsive symptoms and inversely related to moderate and severe symptoms, after controlling for the severity of positive, negative, disorganization and general psychopathological symptoms. The role of obsessive-compulsive symptoms on social functioning in schizophrenia occurs along a severity continuum with a gradual transition from a positive correlation (from absent to mild symptoms) to an inverse correlation (for symptoms ranging from moderate to severe) and independently from schizophrenia symptom dimensions.
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy. mtonna@ausl.pr.it.|Department of Mental Health, Local Health Service, Parma, Italy. mtonna@ausl.pr.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Tonna
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ottoni
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Paglia
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Ossola
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy.|Department of Mental Health, Local Health Service, Parma, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: De Panfilis
authors.affiliation: Department of Neuroscience, Psychiatric Unit, University of Parma, Ospedale Maggiore, Padiglione Braga, Viale A. Gramsci 14, 43126, Parma, Italy.|Department of Mental Health, Local Health Service, Parma, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Marchesi
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D004651:Employment; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000209:etiology* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012919:Social Behavior; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents
keywords: Dimension; Functioning; Obsessive–compulsive symptoms; Positive and negative symptoms; Schizophrenia