title: Lung Volume Reduction in Pulmonary Emphysema from the Radiologist's Perspective.
abstract: Pulmonary emphysema causes decrease in lung function due to irreversible dilatation of intrapulmonary air spaces, which is linked to high morbidity and mortality. Lung volume reduction (LVR) is an invasive therapeutical option for pulmonary emphysema in order to improve ventilation mechanics. LVR can be carried out by lung resection surgery or different minimally invasive endoscopical procedures. All LVR-options require mandatory preinterventional evaluation to detect hyperinflated dysfunctional lung areas as target structures for treatment. Quantitative computed tomography can determine the volume percentage of emphysematous lung and its topographical distribution based on the lung's radiodensity. Modern techniques allow for lobebased quantification that facilitates treatment planning. Clinical tests still play the most important role in post-interventional therapy monitoring, but CT is crucial in the detection of postoperative complications and foreshadows the method's high potential in sophisticated experimental studies. Within the last ten years, LVR with endobronchial valves has become an extensively researched minimally-invasive treatment option. However, this therapy is considerably complicated by the frequent occurrence of functional interlobar shunts. The presence of "collateral ventilation" has to be ruled out prior to valve implantations, as the presence of these extraanatomical connections between different lobes may jeopardize the success of therapy. Recent experimental studies evaluated the automatic detection of incomplete lobar fissures from CT scans, because they are considered to be a predictor for the existence of shunts. To date, these methods are yet to show acceptable results.
  
  
  CONCLUSIONS
  Today, surgical and various minimal invasive methods of lung volume reduction are in use. Radiological and nuclear medical examinations are helpful in the evaluation of an appropriate lung area. Imaging can detect periinterventional complications. Reduction of lung volume has not yet been conclusively proven to be effective and is a therapeutical option with little scientific evidence.
authors.affiliation: Department of Radiology, Charité Universitätsmedizin Berlin, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Doellinger
authors.affiliation: Department of Internal Medicine/Infectious and Respiratory Diseases, Charité Universitätsmedizin Berlin, Germany.
authors.forename: R H
authors.initials: RH
authors.lastname: Huebner
authors.affiliation: Institute for Medical Image Computing, Fraunhofer MEVIS, Bremen, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Kuhnigk
authors.affiliation: Department of Radiology, Charité Universitätsmedizin Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Poellinger
mesh_terms: D001999:Bronchoscopy / Q000379:methods*; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D011013:Pneumonectomy / Q000379:methods*; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D019736:Prostheses and Implants; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000000981:diagnostic imaging* / Q000601:surgery*; D012680:Sensitivity and Specificity; D013906:Thoracoscopy / Q000379:methods*