title: [Histological factors predicting loco-regional lymph node metastasis in early invasive colorectal adenocarcinoma pT1].
abstract: BACKGROUND
  Endoscopic resection is the common treatment in pT1 colorectal adenocarcinoma whenever possible. The presence of adverse histological factors requires subsequent lymph node evaluation.
  
  
  METHODS
  We selected 29 colorectal pT1 adenocarcinoma including endoscopic polypectomies and the corresponding surgical specimens. All histologic parameters associated with N+ were evaluated by 2 pathologists, including: tumor differentiation grade, depth of invasion in the submucosa, angiolymphatic invasion (ALI), perineural invasion, chronic inflammation, tumor budding, poorly differentiated cluster, pre-existing adenoma, tumor border, and endoscopic resection margin. Univariate and multivariate logistic regression analysis were performed to assess the individual capacity of each variable to predict N+.
  
  
  RESULTS
  In the univariate analysis, rectal tumor localization, ALI and poorly differentiated cluster was significantly associated with N+. Among the significant parameters, ALI had the highest area under the ROC curve (0.875). Multivariate analysis showed no independent variables associated with N+.
  
  
  CONCLUSIONS
  We confirm that ALI and the presence of poorly differentiated cluster are frequently associated with N+ in early colorectal cancer. Consequently, these parameters should be routinely evaluated by pathologists.
authors.affiliation: Departamento de Patología, Instituto Valenciano de Oncología, Valencia, España. Electronic address: isidro.machado@uv.es.
authors.forename: Isidro
authors.initials: I
authors.lastname: Machado
authors.affiliation: Becaria de la Fundación AECC, Departamento de Patología, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Miriam
authors.initials: M
authors.lastname: Valera-Alberni
authors.affiliation: Departamento de Gastroenterología, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Fernando
authors.initials: F
authors.lastname: Martínez de Juan
authors.affiliation: Departamento de Biología Molecular, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: José A
authors.initials: JA
authors.lastname: López-Guerrero
authors.affiliation: Departamento de Cirugía, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Alfonso
authors.initials: A
authors.lastname: García Fadrique
authors.affiliation: Departamento de Patología, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Julia
authors.initials: J
authors.lastname: Cruz
authors.affiliation: Departamento de Gastroenterología, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez Lapiedra
authors.affiliation: Departamento de Gastroenterología, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Fernanda Maia
authors.initials: FM
authors.lastname: de Alcantara
authors.affiliation: Departamento de Oncología Clínica, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Yaya
authors.affiliation: Departamento de Cirugía, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Jorge
authors.initials: J
authors.lastname: Campos
authors.affiliation: Departamento de Oncología Clínica, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernández-Martos
authors.affiliation: Departamento de Cirugía, Instituto Valenciano de Oncología, Valencia, España.
authors.forename: Rafael
authors.initials: R
authors.lastname: Estevan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012307:Risk Factors
keywords: Adenocarcinoma pT1; Colorectal cancer; Cáncer colorrectal; Grupos de tumor pobremente diferenciados; Poorly differentiated clusters; pT1 adenocarcinomas