title: Myrtus communis L. Freeze-Dried Aqueous Extract Versus Omeprazol in Gastrointestinal Reflux Disease: A Double-Blind Randomized Controlled Clinical Trial.
abstract: The current work assessed a pharmaceutical dosage form of Myrtus communis L. (myrtle) in reflux disease compared with omeprazol via a 6-week double-blind randomized controlled clinical trial. Forty-five participants were assigned randomly to 3 groups as A (myrtle berries freeze-dried aqueous extract, 1000 mg/d), B (omeprazol capsules, 20 mg/d), and C (A and B). The assessment at the beginning and the end of the study was done by using a standardized questionnaire of frequency scale for the symptoms of gastroesophageal reflux disease (FSSG). In all groups, both reflux and dyspeptic scores significantly decreased in comparison with the respective baselines. Concerning each group, significant changes were found in FSSG, dysmotility-like symptoms and acid reflux related scores. No significant differences were observed between all groups in final FSSG total scores (FSSG2). Further studies with more precise design and larger sample size may lead to a better outcome to suggest the preparation as an alternative intervention.
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad E
authors.initials: ME
authors.lastname: Zohalinezhad
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Kazem
authors.initials: MK
authors.lastname: Hosseini-Asl
authors.affiliation: Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Rahimeh
authors.initials: R
authors.lastname: Akrami
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Department of Traditional Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Nimrouzi
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Salehi
authors.affiliation: Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran zarm@sums.ac.ir.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Zarshenas
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D031651:Myrtus / Q000737:chemistry*; D009853:Omeprazole / Q000737:chemistry / Q000627:therapeutic use*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts; D009853:Omeprazole
keywords: GERD; Myrtus communis L.; clinical trial; gastroesophageal reflux disease; herbal medicine