title: First report of autochthonous transmission of Zika virus in Brazil.
abstract: In the early 2015, several cases of patients presenting symptoms of mild fever, rash, conjunctivitis and arthralgia were reported in the northeastern Brazil. Although all patients lived in a dengue endemic area, molecular and serological diagnosis for dengue resulted negative. Chikungunya virus infection was also discarded. Subsequently, Zika virus (ZIKV) was detected by reverse transcription-polymerase chain reaction from the sera of eight patients and the result was confirmed by DNA sequencing. Phylogenetic analysis suggests that the ZIKV identified belongs to the Asian clade. This is the first report of ZIKV infection in Brazil.
authors.affiliation: Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, PR, Brasil.
authors.forename: Camila
authors.initials: C
authors.lastname: Zanluca
authors.affiliation: Secretaria Estadual de Saúde do Rio Grande do Norte, Natal, RN, Brasil.
authors.forename: Vanessa Campos Andrade de
authors.initials: VC
authors.lastname: Melo
authors.affiliation: Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, PR, Brasil.
authors.forename: Ana Luiza Pamplona
authors.initials: AL
authors.lastname: Mosimann
authors.affiliation: Secretaria Estadual de Saúde do Rio Grande do Norte, Natal, RN, Brasil.
authors.forename: Glauco Igor Viana Dos
authors.initials: GI
authors.lastname: Santos
authors.affiliation: Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, PR, Brasil.
authors.forename: Claudia Nunes Duarte Dos
authors.initials: CN
authors.lastname: Santos
authors.affiliation: Instituto de Medicina Tropical, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
authors.forename: Kleber
authors.initials: K
authors.lastname: Luz
mesh_terms: D000293:Adolescent; D000328:Adult; D000330:Aedes / Q000821:virology*; D000368:Aged; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D055815:Young Adult; D000071244:Zika Virus / Q000235:genetics* / Q000302:isolation & purification; D000071243:Zika Virus Infection / Q000453:epidemiology / Q000473:pathology / Q000635:transmission* / Q000821:virology*
chemical_list: D012367:RNA, Viral