title: Inflammatory-mediated pathway in association with organochlorine pesticides levels in the etiology of idiopathic preterm birth.
abstract: Elevated inflammation is a known risk factor in the pathogenesis of PTB. Despite intensive research, the etiology of idiopathic PTB is still unknown. The present study was designed to explore associations of blood concentrations of organochlorine pesticides (OCPs) with inflammatory/antioxidant gene expression, and cytokines and prostaglandin levels in PTB cases. Significantly high levels of α, β-hexachlorocyclohexane (α, β-HCH), dichlorodiphenyldichloroethane (o'p'-DDD), dichlorodiphenyldichloroethylene (p'p'-DDE), increased expression of cyclooxygenase-2 (COX-2), and decreased expression of manganese superoxide dismutase (Mn-SOD) and catalase (CAT) genes were seen in PTB cases. Also, increased protein levels of interleukin-6 (IL-6) and decreased protein levels of interleukin-4 (IL-4) and prostaglandin F2α (PGF2α) were found in maternal blood of PTB cases as compared to term controls. Elevated levels of β-HCH along with high expression of COX-2 gene or low expression of Mn-SOD or CAT genes were associated with the decrease in the period of gestation (POG).
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India.
authors.forename: Md
authors.initials: M
authors.lastname: Mustafa
authors.affiliation: Department of Obstetrics and Gynaecology, Dilshad Garden, Delhi 110 095, India.
authors.forename: Neha
authors.initials: N
authors.lastname: Garg
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India. Electronic address: banerjeebd@hotmail.com.
authors.forename: B D
authors.initials: BD
authors.lastname: Banerjee
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India.
authors.forename: Tusha
authors.initials: T
authors.lastname: Sharma
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Tyagi
authors.affiliation: Department of Microbiology, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110 095, India.
authors.forename: Sajad Ahmad
authors.initials: SA
authors.lastname: Dar
authors.affiliation: Department of Obstetrics and Gynaecology, Dilshad Garden, Delhi 110 095, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India.
authors.forename: Rafat S
authors.initials: RS
authors.lastname: Ahmad
authors.affiliation: Department of Obstetrics and Gynaecology, Dilshad Garden, Delhi 110 095, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Vaid
authors.affiliation: Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, Dilshad Garden, Delhi 110 095, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Tripathi
mesh_terms: D002374:Catalase / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics; D016207:Cytokines / Q000097:blood; D015237:Dinoprost / Q000097:blood; D005260:Female; D015870:Gene Expression; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D010575:Pesticides / Q000097:blood*; D011247:Pregnancy; D047928:Premature Birth; D013482:Superoxide Dismutase / Q000235:genetics
chemical_list: D016207:Cytokines; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D015237:Dinoprost; D002374:Catalase; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D013482:Superoxide Dismutase
keywords: Cytokines; Gene–environment interactions; Organochlorine pesticides; Preterm birth; Prostaglandins; Women