title: The assessment of immature microvascular density in brain gliomas with dynamic contrast-enhanced magnetic resonance imaging.
abstract: OBJECTIVE
  This study was designed to quantitatively evaluate the immature microvascular density (MVD) of brain gliomas using the volume transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tissue (Ve) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) noninvasively.
  
  
  METHODS
  Fifty-seven patients (35 males, 22 females; age range, 14-70, mean age 46±12 years old) with brain glioma were included in this study. The maximal values of K(trans) and Ve of all patients with brain glioma (grade II 24, III 7 and IV 26) were obtained. The CD105-microvascular density (CD105-MVD) of each tumor was measured in surgical specimen. The differences of K(trans), Ve and CD105-MVD between the different grades of gliomas were analyzed using the Mann-Whitney U-test. The Pearman correlation coefficient was determined between K(trans), Ve and CD105-MVD. A P-value of less than 0.05 was considered statistically significant.
  
  
  RESULTS
  The differences in K(trans), Ve and CD105-MVD were statistically significant between low-grade glioma (LGG) and high-grade glioma (HGG) (P=0.001, P<0.001, P<0.001). The K(trans), Ve and CD105-MVD of grade II were significantly lower than those of grade III and IV. K(trans) and Ve were positively correlated with CD105-MVD in HGG (P<0.001, P<0.001).
  
  
  CONCLUSIONS
  Our results suggest DCE-MRI plays an important part in noninvasively evaluating the immature MVD of brain gliomas.
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: jzz2397@163.com.
authors.forename: Zhong Zheng
authors.initials: ZZ
authors.lastname: Jia
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: guhongmei71@163.com.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Gu
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: zxj0925101@sina.com.
authors.forename: Xue Jun
authors.initials: XJ
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, PR China. Electronic address: shij_ns@163.com.
authors.forename: Jin Long
authors.initials: JL
authors.lastname: Shi
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: 115218103@qq.com.
authors.forename: Min Da
authors.initials: MD
authors.lastname: Li
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: 292768853@qq.com.
authors.forename: Guo Feng
authors.initials: GF
authors.lastname: Zhou
authors.affiliation: Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: wuxianhua58@sohu.com.
authors.forename: Xian Hua
authors.initials: XH
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005910:Glioma / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055806:Microvessels; D008875:Middle Aged; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: CD105; Dynamic contrast-enhanced; Glioma; MRI; Microvascular density; Volume transfer constant