title: Paroxysmal cold hemoglobinuria due to an IgA Donath-Landsteiner antibody.
abstract: Paroxysmal cold hemoglobinuria (PCH) is an autoimmune hemolytic anemia (AIHA) characterized by the presence of a Donath-Landsteiner (D-L) antibody. PCH occurs most commonly in young children and is associated with acute, often self-limited hemolytic anemia. The D-L antibody is classically a biphasic IgG anti-P autoantibody identified by the D-L test. Rare case reports confirm the existence of IgM D-L antibodies. We report the case of a 2-year-old male diagnosed with acute AIHA and found to have PCH caused by an IgA D-L antibody. The clinical course and treatment of this condition, which has not been reported previously, are described.
authors.affiliation: Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors.forename: Nicholas S
authors.initials: NS
authors.lastname: Whipple
authors.affiliation: Le Bonheur Children's Hospital, Memphis, Tennessee.
authors.forename: Dawn A B
authors.initials: DA
authors.lastname: Moreau
authors.affiliation: John J. Moulds Scientific Support Services, LifeShare Blood Centers, Shreveport, Louisiana.
authors.forename: JoAnn M
authors.initials: JM
authors.lastname: Moulds
authors.affiliation: Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors.forename: Jane S
authors.initials: JS
authors.lastname: Hankins
authors.affiliation: Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors.forename: Winfred C
authors.initials: WC
authors.lastname: Wang
authors.affiliation: Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee.
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Nottage
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002675:Child, Preschool; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male
chemical_list: D001323:Autoantibodies; C067477:Donath-Landsteiner antibody; D007070:Immunoglobulin A
keywords: Donath-Landsteiner antibody; IgA; autoimmune hemolytic anemia; paroxysmal cold hemoglobinuria