title: The evaluation of Nesfatin-1 levels in patients with and without intrauterine growth restriction.
abstract: OBJECTIVE
  To evaluate Nesfatin-1 levels in patients with and without intrauterine growth restriction and to analyze the correlation between Nesfatin-1 levels and fetal birth weights.
  
  
  METHODS
  This study comprised a total of 81 cases; 41 patients with IUGR and 40 healthy cases. Demographic data, pregnancy weeks, fetal birth weights and Nesfatin-1 levels were all recorded. The Nesfatin-1 levels were compared between the groups and the correlation between fetal birth weights and Nesfatin-1 levels was analyzed.
  
  
  RESULTS
  No statistical significant difference was determined between the groups in terms of demographic data (p > 0.05). Average birth weights were determined as 3420 ± 259 g in the control group and 2041 ± 350 g in the IUGR group, which was found to be statistically unequal (p = 0.001). The average Nesfatin levels in the control group were 0.069 ± 0.011 and 0.094 ± 0.042 in the IUGR group. This difference was statistically unequal (p = 0.001). While no correlation was determined between Nesfatin levels and fetal birthweights in the control group (r = -0.034 versus p = 0.836), in the IUGR group and when all the cases were evaluated together, a statistically moderately significant negative correlation was determined (r = -0.469, p = 0.002 and r = -0.251, p = 0.024, respectively).
  
  
  CONCLUSIONS
  Although intrauterine growth is a multifactorial process, the effect mechanism has not yet been established. The results of this study offer some indications about the possible effect of Nesfatin 1 on fetal growth.
authors.affiliation: a Department of Obstetrics and Gynecology , Tatvan State Hospital , Bitlis , Turkey .
authors.forename: Salih
authors.initials: S
authors.lastname: Serin
authors.affiliation: b Department of Obstetrics and Gynecology , Kahramanmaras Sutcu Imam University, School of Medicine , Kahramanmaraş , Turkey , and.
authors.forename: Murat
authors.initials: M
authors.lastname: Bakacak
authors.affiliation: b Department of Obstetrics and Gynecology , Kahramanmaras Sutcu Imam University, School of Medicine , Kahramanmaraş , Turkey , and.
authors.forename: Önder
authors.initials: Ö
authors.lastname: Ercan
authors.affiliation: b Department of Obstetrics and Gynecology , Kahramanmaras Sutcu Imam University, School of Medicine , Kahramanmaraş , Turkey , and.
authors.forename: Bülent
authors.initials: B
authors.lastname: Köstü
authors.affiliation: c Department of Obstetrics and Gynecology , Patnos State Hospital , Ağrı , Turkey.
authors.forename: Fazıl
authors.initials: F
authors.lastname: Avci
authors.affiliation: b Department of Obstetrics and Gynecology , Kahramanmaras Sutcu Imam University, School of Medicine , Kahramanmaraş , Turkey , and.
authors.forename: Deniz
authors.initials: D
authors.lastname: Arıkan
authors.affiliation: b Department of Obstetrics and Gynecology , Kahramanmaras Sutcu Imam University, School of Medicine , Kahramanmaraş , Turkey , and.
authors.forename: Gürkan
authors.initials: G
authors.lastname: Kıran
mesh_terms: D000293:Adolescent; D000328:Adult; D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D011247:Pregnancy; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
keywords: Fetal weight; Nesfatin-1; intrauterine growth restriction