title: When is an acoustic neuroma not an acoustic neuroma? Pitfalls for radiosurgeons.
abstract: BACKGROUND
  Because acoustic neuroma (AN), also termed vestibular schwannoma, constitutes by far the commonest intracranial schwannoma and cerebello-pontine angle (CPA) tumour, there is a risk of overlooking rarer alternative diagnoses with similar clinical and/or radiological features. The purpose of this article is to highlight to radiosurgeons the potentially serious implications of this problem through illustrative case studies.
  
  
  METHODS
  Our linac stereotactic radiosurgery (SRS) technique has been previously described, with stereotactic headring fixation and treatment delivered via cones or micro-multileaf collimators using multiple arcs or static beams.
  
  
  RESULTS
  Between November 1993 and October 2014, we treated 132 patients referred with a clinical diagnosis of AN, the vast majority with 12 Gy marginal dose. Three of these (2.3%), evident either at the time of treatment (2) or subsequently (1), had features instead consistent with cochlear schwannoma, facial schwannoma and meningioma, respectively. Each warranted significant modification to standard AN outlining and fields. The meningioma progressed due to geographic miss. One other patient with recurrent facial schwannoma (not yet needing SRS) was also referred with an incorrect diagnosis of AN.
  
  
  CONCLUSIONS
  When rare variants of common medical problems are not identified before referral, there is a risk that 'blinkering' can lead to misdiagnosis and suboptimal treatment. Radiosurgeons need to be particularly mindful of this issue with AN, which can mimic several other tumours occurring in the CPA region, albeit with different patterns of spread. Optimal imaging, high-quality radiology reporting and neuroradiology input at the time of SRS planning within the setting of a specialised multidisciplinary team are highly desirable.
authors.affiliation: Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Roos
authors.affiliation: Department of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Sandy G
authors.initials: SG
authors.lastname: Patel
authors.affiliation: Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Potter
authors.affiliation: Department of Neurosurgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.|School of Surgery, University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Zacest
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019300:Medical Errors / Q000517:prevention & control*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology* / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome
keywords: acoustic neuroma; cochlear schwannoma; facial schwannoma; meningioma; stereotactic radiosurgery