title: Prognostic Value of (18)F-FDG PET-CT in Nasopharyngeal Carcinoma: Is Dynamic Scanning Helpful?
abstract: OBJECTIVE
  To evaluate the differences in prognostic values of static and dynamic PET-CT in nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  Forty-five patients who had static scan were recruited. Sixteen had dynamic scan. The primary lesions were delineated from standardized uptake value (SUV) maps from static scan and K i maps from dynamic scan. The average follow-up lasted for 34 months. The patients who died or those with recurrence/residual disease were considered "poor outcome"; otherwise they were considered "good outcome." Fisher's exact test and ROC analysis were used to evaluate the prognostic value of various factors.
  
  
  RESULTS
  Tumor volume thresholded by 40% of maximal SUV (VOLSUV40) significantly predicted treatment outcome (p = 0.024) in the whole cohort. In 16 patients with dynamic scan, all parameters by dynamic scan were insignificant in predicting the outcome. The combination of maximal SUV, maximal K i , VOLSUV40, and VOL K i 37 (the tumor volume thresholded by 37% maximal K i ) achieved the highest predicting accuracy for treatment outcome with sensitivity, specificity, and accuracy of 100% in these 16 patients; however this improvement compared to VOLSUV40 was insignificant.
  
  
  CONCLUSIONS
  Tumor volume from static scan is useful in NPC prognosis. However, the role of dynamic scanning was not justified in this small cohort.
authors.affiliation: Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong.
authors.forename: Bingsheng
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Diagnostic Radiology and Molecular Imaging, Oakland University William Beaumont School of Medicine, Royal Oak, MI 48073, USA.
authors.forename: Ching-Yee Oliver
authors.initials: CY
authors.lastname: Wong
authors.affiliation: Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lai
authors.affiliation: Department of Clinical Oncology, Queen Mary Hospital, Hong Kong.
authors.forename: Dora Lai-Wan
authors.initials: DL
authors.lastname: Kwong
authors.affiliation: Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong.
authors.forename: Pek-Lan
authors.initials: PL
authors.lastname: Khong
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D049268:Positron-Emission Tomography; D011379:Prognosis; D011859:Radiography
chemical_list: D019788:Fluorodeoxyglucose F18