title: Co-existent B-cell and plasma cell neoplasms: a case series providing novel clinical insight.
abstract: Concomitant plasma cell (PCN) and B-cell neoplasms (BCN) in a single patient have been infrequently reported. This study reviewed nine such patients at the institution - six had multiple myeloma (MM) associated with a BCN (MM/B group) and three had AL amyloidosis (ALA) with a BCN (ALA/B group). This study describes two syndromes of MM/B - three patients presented with CLL and subsequently developed MM, while three presented with MM and monoclonal B-cell lymphocytosis. In the ALA/B group, all three patients had systemic ALA and a BCN. Responses of the BCN and PCN to treatment correlated. In the two patients whose MM relapsed, the BCN simultaneously relapsed. The finding that the BCN may relapse in tandem with the MM argues against a coincidental relationship between the two.
authors.affiliation: a Division of Hematology and Hematologic Malignancies, University of Calgary , Calgary AB , Canada.
authors.forename: Kareem
authors.initials: K
authors.lastname: Jamani
authors.affiliation: a Division of Hematology and Hematologic Malignancies, University of Calgary , Calgary AB , Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Duggan
authors.affiliation: a Division of Hematology and Hematologic Malignancies, University of Calgary , Calgary AB , Canada.
authors.forename: Paola
authors.initials: P
authors.lastname: Neri
authors.affiliation: a Division of Hematology and Hematologic Malignancies, University of Calgary , Calgary AB , Canada.
authors.forename: Nizar
authors.initials: N
authors.lastname: Bahlis
authors.affiliation: a Division of Hematology and Hematologic Malignancies, University of Calgary , Calgary AB , Canada.
authors.forename: Victor H
authors.initials: VH
authors.lastname: Jimenez-Zepeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015448:Leukemia, B-Cell / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D054219:Neoplasms, Plasma Cell / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D010641:Phenotype; D016896:Treatment Outcome
keywords: AL amyloidosis; B-cell neoplasm; Multiple myeloma; chronic lymphocytic leukemia; monoclonal B-cell lymphocytosis