title: Analgesic, Anti-inflammatory and neuropharmacological effects of Atropa belladonna.
abstract: The present study was carried out to investigate, in vivo, analgesic, anti-inflammatory and neuro-pharmacological activities of the methanolic extract of Atropa belladonna. The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuro-pharmacological activities were evaluated by open field, rearing test, cage cross, swim test, head dip and traction tests. The anti-inflammatory activity was assessed by formalin induce inflammation on hind paw. The extract showed highly significant (p<0.001) analgesic activity with % inhibitions of writhing response at doses 100 and 300mg/kg body weight were 28.5% and 57.1%, respectively. The extract at both doses showed significant (p<0.05) sedative effect in-cage cross test and highly significance value (p<0.001) in high dose. In-open field test, the extract showed significant (P<0.05) anxiolytic activity at higher dose whereas in rearing test activity shows significant p-value at both doses. The extract also showed significant value for anti-inflammatory activity. The findings of the study clearly indicated the presence of significant analgesic, neuro-pharmacological and anti-inflammatory properties of the plant, which demands further investigation including, compounds isolation.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Owais
authors.affiliation: Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Anwar
authors.affiliation: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Farah
authors.initials: F
authors.lastname: Saeed
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Baluchistan, Quetta, Pakistan.
authors.forename: Shafi
authors.initials: S
authors.lastname: Muhammad
authors.affiliation: Department of Pharmacognosy, University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
authors.forename: Saiqa
authors.initials: S
authors.lastname: Ishtiaque
authors.affiliation: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Omair
authors.initials: O
authors.lastname: Mohiuddin