title: The Total Synthesis of Retrojusticidin B, Justicidin E, and Helioxanthin.
abstract: Making use of a tandem free radical cyclization process mediated by Mn(OAc)3 as a key operation, the total synthesis of retrojusticidin B, justicidin E, and helioxanthin has been concisely achieved in four or five steps in an overall yield of 45, 33 and 44%, respectively, from a common starting material 5.
authors.affiliation: †Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, R.O.C.|‡Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, R.O.C.
authors.forename: Tzu-Ting
authors.initials: TT
authors.lastname: Kao
authors.affiliation: †Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, R.O.C.
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Lin
authors.affiliation: ‡Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, R.O.C.
authors.forename: Kak-Shan
authors.initials: KS
authors.lastname: Shia
mesh_terms: D002384:Catalysis; D003500:Cyclization; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004148:Dioxolanes; D017705:Lignans; D009281:Naphthalenes; C505802:helioxanthin; C049719:justicidins; C496008:retrojusticidin B