title: Mitral Valve Stenosis Progression Due to Severe Calcification on Glutaraldehyde-Treated Autologous Pericardium: Word of Caution for an Attractive Repair Technique.
abstract: A 42-year-old woman presented with a 6-month history of palpitations and progressive dyspnea on exertion. She had undergone aortic and mitral valve repair using glutaraldehyde-treated autologous pericardium for active infective endocarditis 5 years prior. Transthoracic echocardiography showed mitral valve stenosis with limited movement of the anterior leaflet. At redo surgery, severe calcification of the glutaraldehyde-treated pericardial patch on the anterior mitral leaflet was observed. Double valve replacement was performed with pulmonary vein isolation. Pathologic examination showed calcification of the glutaraldehyde-treated autologous pericardium. The patient was discharged on postoperative day 11 with oral anticoagulant therapy.
authors.affiliation: Department of Cardiovascular Surgery, Kobe City Medical Center General Hospital, Kobe, Japan. Electronic address: naotowakimachi@hotmail.co.jp.
authors.forename: Naoto
authors.initials: N
authors.lastname: Fukunaga
authors.affiliation: Department of Cardiovascular Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Takehiko
authors.initials: T
authors.lastname: Matsuo
authors.affiliation: Department of Cardiovascular Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saji
authors.affiliation: Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Imai
authors.affiliation: Department of Cardiovascular Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Koyama
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D018450:Disease Progression; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005404:Fixatives / Q000009:adverse effects; D005976:Glutaral / Q000009:adverse effects*; D006801:Humans; D008946:Mitral Valve Stenosis / Q000175:diagnosis / Q000209:etiology*; D010496:Pericardium / Q000187:drug effects / Q000473:pathology* / Q000637:transplantation; D014021:Tissue Preservation; D014182:Transplantation, Autologous / Q000009:adverse effects
chemical_list: D005404:Fixatives; D005976:Glutaral