title: Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet.
abstract: Dietary intake of advanced glycation end-products (AGEs) increases circulating and tissue levels of these substances, contributing to a state of increased oxidative stress and inflammation. A low dietary AGE intervention has been shown to reduce body AGE content. Mediterranean diets (MD) are theoretically considered low in AGEs, but the specific effects of a MD on AGEs serum levels has not been tested.
  
  
  METHODS
  Forty-seven overweight and obese premenopausal women underwent a three-month calorie restriction treatment (20 kcal/kg initial weight) with a Mediterranean-type diet that excluded wine intake. The adherence to the MD was assessed before and at the end of treatment using an on-line questionnaire, which scores from 0 to 14 (minimal to maximal adherence). Body composition, insulin resistance, lipoproteins and carboxymethyl-lisine (CML) serum levels were measured at both time periods. Serum CML was assessed through ELISA (enzyme-linked immunosorbent assay). Compliance to calorie restriction was assessed according to weight loss (< or > 5% initial weight).
  
  
  RESULTS
  Mean body weight, body fat, waist circumference, total cholesterol, triglycerides and serum CML fell significantly, together with an increase in the Mediterranean score, although none of the patients reached the highest score. Significant changes in CML and insulin resistance were observed in 17 women classified as compliant to caloric restriction, but not in the 27 participants who were considered adherent to the MD (according to improvement of the Mediterranean Score).
  
  
  CONCLUSIONS
  CML serum levels can be reduced through calorie restricted-Mediterranean-type diet. We could not reach a high enough MD score, so we cannot conclude whether the MD itself has an additive effect to caloric restriction.
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Rodríguez
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Laura
authors.initials: L
authors.lastname: Leiva Balich
authors.affiliation: Clínica Alemana - Universidad del Desarrollo, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: M J
authors.initials: MJ
authors.lastname: Concha
authors.affiliation: Clínica Alemana - Universidad del Desarrollo, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: C
authors.initials: C
authors.lastname: Mizón
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bunout Barnett
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Gladys
authors.initials: G
authors.lastname: Barrera Acevedo
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hirsch Birn
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. teresajimenezjaime@gmail.com.
authors.forename: Teresa
authors.initials: T
authors.lastname: Jiménez Jaime
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: Sandra
authors.initials: S
authors.lastname: Henríquez
authors.affiliation: The Icahn School of Medicine at Mount Sinai, New York, NY. FUNDING: FONDECYT Grants # 1130284 and 1110035, Chile.. mpmaza@inta.uchile.cl.
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile.. mpmaza@inta.uchile.cl.
authors.forename: María Pía
authors.initials: MP
authors.lastname: de la Maza Cave
mesh_terms: D000328:Adult; D015992:Body Mass Index; D031204:Caloric Restriction; D038441:Diet, Mediterranean; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy; D050177:Overweight / Q000097:blood / Q000178:diet therapy; D010349:Patient Compliance
chemical_list: D017127:Glycation End Products, Advanced