title: Are Developmental Trajectories of Cortical Folding Comparable Between Cross-sectional Datasets of Fetuses and Preterm Newborns?
abstract: Magnetic resonance imaging has proved to be suitable and efficient for in vivo investigation of the early process of brain gyrification in fetuses and preterm newborns but the question remains as to whether cortical-related measurements derived from both cases are comparable or not. Indeed, the developmental folding trajectories drawn up from both populations have not been compared so far, neither from cross-sectional nor from longitudinal datasets. The present study aimed to compare features of cortical folding between healthy fetuses and early imaged preterm newborns on a cross-sectional basis, over a developmental period critical for the folding process (21-36 weeks of gestational age [GA]). A particular attention was carried out to reduce the methodological biases between the 2 populations. To provide an accurate group comparison, several global parameters characterizing the cortical morphometry were derived. In both groups, those metrics provided good proxies for the dramatic brain growth and cortical folding over this developmental period. Except for the cortical volume and the rate of sulci appearance, they depicted different trajectories in both groups suggesting that the transition from into ex utero has a visible impact on cortical morphology that is at least dependent on the GA at birth in preterm newborns.
authors.affiliation: Aix-Marseille Université, CNRS, ENSAM, Université de Toulon, LSIS UMR 7296, 13397 Marseille, France Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, 13385 Marseille, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Lefèvre
authors.affiliation: Service de Neurologie Pédiatrique et Pathologie Métabolique, APHP, Hôpital Robert Debré, DHU PROTECT, 75019 Paris, France Université Paris Diderot, Sorbonne Paris Cité, 75013 Paris, France CEA, NeuroSpin, UNIACT, UNIPEDIA, 91191 Gif-sur-Yvette, France INSERM, U1129, 75015 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Germanaud
authors.affiliation: Cognitive Neuroimaging Unit, INSERM, U992, 91191 Gif-sur-Yvette, France NeuroSpin Center, CEA, 91191 Gif-sur-Yvette, France University Paris Sud, 91400 Orsay, France.
authors.forename: Jessica
authors.initials: J
authors.lastname: Dubois
authors.affiliation: Institut Mines-Telecom, Telecom Bretagne, INSERM U1101 LaTIM, 29609 Brest, France.
authors.forename: François
authors.initials: F
authors.lastname: Rousseau
authors.affiliation: CEA, NeuroSpin Center, UNATI, 91191 Gif-sur-Yvette, France.
authors.forename: Ines
authors.initials: I
authors.lastname: de Macedo Santos
authors.affiliation: Cognitive Neuroimaging Unit, INSERM, U992, 91191 Gif-sur-Yvette, France NeuroSpin Center, CEA, 91191 Gif-sur-Yvette, France University Paris Sud, 91400 Orsay, France.
authors.forename: Hugo
authors.initials: H
authors.lastname: Angleys
authors.affiliation: CEA, NeuroSpin Center, UNATI, 91191 Gif-sur-Yvette, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mangin
authors.affiliation: Department of Pediatrics, Geneva University Hospitals, 1211 Genève 14, Switzerland Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Petra S
authors.initials: PS
authors.lastname: Hüppi
authors.affiliation: Aix Marseille Université, CNRS, CRMBM UMR 7339, 13385 Marseille, France Service de Neuroradiologie, Hôpital de La Timone, 13005 Marseille, France.
authors.forename: Nadine
authors.initials: N
authors.lastname: Girard
authors.affiliation: CEA, NeuroSpin Center, UNATI, 91191 Gif-sur-Yvette, France Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, 75010 Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: De Guio
mesh_terms: D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000254:growth & development*; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006801:Humans; D021621:Imaging, Three-Dimensional; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D008279:Magnetic Resonance Imaging; D009929:Organ Size; D011296:Prenatal Diagnosis; D012189:Retrospective Studies
keywords: cortical surface; curvature; development of cortical sulci; fetal MRI; in utero; morphometry; premature birth; segmentation