title: StIL-17 gene polymorphisms in the development of pulmonary tuberculosis.
abstract: We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB.
  
  
  METHODS
  The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP).
  
  
  RESULTS
  The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92).
  
  
  CONCLUSIONS
  In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
authors.forename: Jichang
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
authors.forename: Xiandong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Huaihe Hospital of Henan University Kaifeng, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Health and Social Behavior, West China School of Public Health, Sichuan University Chengdu, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17
keywords: IL-17; polymorphism; pulmonary tuberculosis