title: Oxidative stress factors and C-reactive protein in patients with oral lichen planus before and 2 weeks after treatment.
abstract: OBJECTIVE
  Oral lichen planus (OLP) is an inflammatory disease with an unknown origin. Oxidative stress is suspected to play a role in its pathogenesis. The aim of this study was to evaluate serum levels of oxidative stress factors and C-reactive protein in patients with OLP.
  
  
  METHODS
  In this case-control study, 25 patients with OLP and 23 control subjects were enrolled. Serum levels of C-reactive protein (CRP), malondialdehyde (MDA), and total antioxidant capacity (TAC) were investigated in both groups. In case group, all these factors were re-evaluated after 14 days of treatment. The characteristics of the lesions were also recorded at each visit.
  
  
  RESULTS
  Serum levels of MDA were significantly higher (P = 0.009), and TAC was significantly lower (P < 0.001) in patients with OLP. There were no significant differences between serum levels of TAC, CRP, and MDA in patients with OLP before and after treatment (P = 0.174, P = 0.556, P = 0.194, respectively). However, the difference in serum levels of TAC between erosive and atrophic patients with keratotic OLP was significant (P = 0.024).
  
  
  CONCLUSIONS
  We concluded patients with OLP have increased of serum MDA and the decrease of serum TAC compared with the healthy subjects, and 14-day treatment of OLP did not have any effect on serum levels of oxidative stress factors.
authors.affiliation: Surgical Oncology Research Center, Imam Reza hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyed Isaac
authors.initials: SI
authors.lastname: Hashemy
authors.affiliation: School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Shideh
authors.initials: S
authors.lastname: Gharaei
authors.affiliation: School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Vasigh
authors.affiliation: School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Kargozar
authors.affiliation: School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Banafsheh
authors.initials: B
authors.lastname: Alirezaei
authors.affiliation: School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Fereshteh Jahed
authors.initials: FJ
authors.lastname: Keyhani
authors.affiliation: Oral and Maxillofacial Diseases Research Center, Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Amirchaghmaghi
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009067:Mouthwashes / Q000008:administration & dosage; D009761:Nystatin / Q000008:administration & dosage; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009067:Mouthwashes; D009761:Nystatin; D008315:Malondialdehyde; D003907:Dexamethasone; D002097:C-Reactive Protein
keywords: C-reactive protein; malondialdehyde; oral lichen planus; oxidative stress; total antioxidant capacity