title: Data Resource Profile: Clinical Practice Research Datalink (CPRD).
abstract: The Clinical Practice Research Datalink (CPRD) is an ongoing primary care database of anonymised medical records from general practitioners, with coverage of over 11.3 million patients from 674 practices in the UK. With 4.4 million active (alive, currently registered) patients meeting quality criteria, approximately 6.9% of the UK population are included and patients are broadly representative of the UK general population in terms of age, sex and ethnicity. General practitioners are the gatekeepers of primary care and specialist referrals in the UK. The CPRD primary care database is therefore a rich source of health data for research, including data on demographics, symptoms, tests, diagnoses, therapies, health-related behaviours and referrals to secondary care. For over half of patients, linkage with datasets from secondary care, disease-specific cohorts and mortality records enhance the range of data available for research. The CPRD is very widely used internationally for epidemiological research and has been used to produce over 1000 research studies, published in peer-reviewed journals across a broad range of health outcomes. However, researchers must be aware of the complexity of routinely collected electronic health records, including ways to manage variable completeness, misclassification and development of disease definitions for research.
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK, Emily.Herrett@lshtm.ac.uk.
authors.forename: Emily
authors.initials: E
authors.lastname: Herrett
authors.affiliation: Clinical Practice Research Datalink, Medicines and Healthcare Products Regulatory Agency, London, UK, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands and.
authors.forename: Arlene M
authors.initials: AM
authors.lastname: Gallagher
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Bhaskaran
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Harriet
authors.initials: H
authors.lastname: Forbes
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Rohini
authors.initials: R
authors.lastname: Mathur
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands and Health eResearch Centre, University of Manchester, Manchester, UK.
authors.forename: Tjeerd
authors.initials: T
authors.lastname: van Staa
authors.affiliation: London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Liam
authors.initials: L
authors.lastname: Smeeth
mesh_terms: D035843:Biomedical Research; D000068598:Data Accuracy; D019992:Databases as Topic; D057286:Electronic Health Records; D058005:General Practitioners; D006801:Humans; D011320:Primary Health Care; D006113:United Kingdom