title: Noncoding RNAs, cytokines, and inflammation-related diseases.
abstract: Chronic inflammation is involved in the onset and development of many diseases, including obesity, atherosclerosis, type 2 diabetes, osteoarthritis, autoimmune and degenerative diseases, asthma, periodontitis, and cirrhosis. The inflammation process is mediated by chemokines, cytokines, and different inflammatory cells. Although the molecules and mechanisms that regulate this primary defense mechanism are not fully understood, recent findings offer a putative role of noncoding RNAs, especially microRNAs (miRNAs), in the progression and management of the inflammatory response. These noncoding RNAs are crucial for the stability and maintenance of gene expression patterns that characterize some cell types, tissues, and biologic responses. Several miRNAs, such as miR-126, miR-132, miR-146, miR-155, and miR-221, have emerged as important transcriptional regulators of some inflammation-related mediators. Additionally, little is known about the involvement of long noncoding RNAs, long intergenic noncoding RNAs, and circular RNAs in inflammation-mediated processes and the homeostatic imbalance associated with metabolic disorders. These noncoding RNAs are emerging as biomarkers with diagnosis value, in prognosis protocols, or in the personalized treatment of inflammation-related alterations. In this context, this review summarizes findings in the field, highlighting those noncoding RNAs that regulate inflammation, with emphasis on recognized mediators such as TNF-α, IL-1, IL-6, IL-18, intercellular adhesion molecule 1, VCAM-1, and plasminogen activator inhibitor 1. The down-regulation or antagonism of the noncoding RNAs and the administration of exogenous miRNAs could be, in the near future, a promising therapeutic strategy in the treatment of inflammation-related diseases.
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Marques-Rocha
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: Mirian
authors.initials: M
authors.lastname: Samblas
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: Fermin I
authors.initials: FI
authors.lastname: Milagro
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: Josefina
authors.initials: J
authors.lastname: Bressan
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
authors.affiliation: *Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa, Brazil; Department of Nutrition, Food Science, and Physiology, Center for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Physiopathology of Obesity, Carlos III Institute, Madrid, Spain; and Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain amarti@unav.es.
authors.forename: Amelia
authors.initials: A
authors.lastname: Marti
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D035683:MicroRNAs / Q000276:immunology*; D062085:RNA, Long Noncoding / Q000276:immunology*
chemical_list: D016207:Cytokines; D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: circular RNA; lincRNA; lncRNA; microRNA; obesity