title: Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress.
abstract: It is believed that glucocorticoids control the proliferation of neural progenitor cells, and this process is highly involved in mood disorders and cognitive processes. Using the maternal separation model of chronic neonatal stress, it has been found that stress induced depressive-like behavior, cognitive deficits and a decrease in proliferation in the subventricular zone (SVZ). Venlafaxine reversed all deleterious effects of chronic stress by modulating HPA activity. These outcomes suggest modulation of stress-mediated glucocorticoid secretion as a target for the treatment of mood disorders and neurodegenerative processes.
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Martisova
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
authors.forename: Bárbara
authors.initials: B
authors.lastname: Aisa
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Tordera
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Puerta
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
authors.forename: Maite
authors.initials: M
authors.lastname: Solas
authors.affiliation: Department of Pharmacology and Toxicology, University of Navarra, IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain. Electronic address: mariaja@unav.es.
authors.forename: María J
authors.initials: MJ
authors.lastname: Ramirez
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003072:Cognition Disorders / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D020547:Lateral Ventricles / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D008426:Maternal Deprivation; D011897:Random Allocation; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000097:blood; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D000069470:Venlafaxine Hydrochloride / Q000494:pharmacology*
chemical_list: D011965:Receptors, Glucocorticoid; D000069470:Venlafaxine Hydrochloride; D003345:Corticosterone
keywords: Corticosterone; Depression; Experimental model of AD; Glucocorticoid receptor; Maternal separation; Stress