title: Low SOD activity is associated with overproduction of peroxynitrite and nitric oxide in patients with acute coronary syndrome.
abstract: OBJECTIVE
  The present study was undertaken to evaluate the variation of the oxidative/nitrosative stress status in a population of subjects; with acute coronary syndrome (ACS), and examine its possible implication in plaque rupture which is the main mechanism in the pathophysiology of ACS.
  
  
  METHODS
  We made this study on 50 men with ACS and 50 age and sex matched healthy controls. Nitrosative/oxidative stress markers including; nitric oxide, superoxide anion levels, superoxide dismutase (SOD) activity and peroxynitrite levels were evaluated in blood samples of patients and controls.
  
  
  RESULTS
  Compared with healthy subjects, coronary patients had significantly higher nitric oxide, peroxynitrite and superoxide anion concentrations in both plasma and erythrocytes associated to significant decrease of SOD activity. Erythrocytes peroxynitrite concentration was negatively correlated with the antioxidant enzyme activity (SOD).
  
  
  CONCLUSIONS
  Our results show a significant accumulation of both intracellular and plasma pro-oxidants with a concomitant decrease in the SOD scavenging activity in ACS patients. Both seem to be associated with plaque rupture and ischemia observed in ACS.
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria.
authors.forename: Sabah
authors.initials: S
authors.lastname: Gheddouchi
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria. Electronic address: nassima_amel@yahoo.fr.
authors.forename: Nassima
authors.initials: N
authors.lastname: Mokhtari-Soulimane
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria.
authors.forename: Hafida
authors.initials: H
authors.lastname: Merzouk
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria.
authors.forename: Fadia
authors.initials: F
authors.lastname: Bekhti
authors.affiliation: Cardiology Department of Tlemcen University Hospital Center, Tlemcen 13000, Algeria.
authors.forename: Fayçal
authors.initials: F
authors.lastname: Soulimane
authors.affiliation: Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition(PPABIONUT), Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, Abou-Bekr Belkaïd University, Tlemcen 13000, Algeria.
authors.forename: Baya
authors.initials: B
authors.lastname: Guermouche
authors.affiliation: Cardiology Department of Tlemcen University Hospital Center, Tlemcen 13000, Algeria.
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Meziane Tani
authors.affiliation: INSERM UMR 866, "Lipids Nutrition Cancer", Faculty of Life, Earth, and Environment Sciences, University of Burgundy, Dijon 21000, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Narce
mesh_terms: D054058:Acute Coronary Syndrome / Q000201:enzymology* / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D030421:Peroxynitrous Acid / Q000097:blood / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
chemical_list: D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D013482:Superoxide Dismutase
keywords: Acute coronary syndromes; Atherosclerosis; Free radicals; Ischemia; Oxidative stress