title: Brain activity during source memory retrieval in young, middle-aged and old adults.
abstract: We investigated neurofunctional changes associated with source memory decline across the adult life span using functional magnetic resonance imaging (fMRI). Young, middle-aged and old adults carried out a natural/artificial judgment of images of common objects that were randomly presented in one of the quadrants of the screen. At retrieval, the images were displayed at the center of the screen and the participants judged whether each image was new or old and, if old, they indicated in which quadrant of the screen the image had originally been presented. Comparing the items associated with correct versus incorrect source judgments revealed that no regions showed greater activity in young adults than in middle-aged adults; however, in young and middle-aged adults the activity in the left hippocampus and left anterior temporal cortex was of greater magnitude than in the older adults. Several regions also exhibited greater activity in young adults than in old adults. These results suggest that in middle age the recollection neural network, assessable by fMRI, is still preserved.
authors.affiliation: Laboratory of NeuroCognition, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, Mexico. Electronic address: selene@unam.mx.
authors.forename: Selene
authors.initials: S
authors.lastname: Cansino
authors.affiliation: Laboratory of NeuroCognition, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Trejo-Morales
authors.affiliation: Laboratory of NeuroCognition, Faculty of Psychology, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: Cinthya
authors.initials: C
authors.lastname: Estrada-Manilla
authors.affiliation: Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico.
authors.forename: Erick Humberto
authors.initials: EH
authors.lastname: Pasaye-Alcaraz
authors.affiliation: Cognition and Behavior Unity, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors.forename: Erika
authors.initials: E
authors.lastname: Aguilar-Castañeda
authors.affiliation: Department of Neuroimaging, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors.forename: Perla
authors.initials: P
authors.lastname: Salgado-Lujambio
authors.affiliation: Laboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Sosa-Ortiz
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Aging; Episodic memory; Functional magnetic resonance imaging; Source memory