title: Erythema, papules, and arthralgia associated with liver cancer: report of a rare case of multicentric reticulohistiocytosis.
abstract: We report a rare case of multicentric reticulohistiocytosis (MRH) associated with liver carcinoma. A 36-year-old man who had been diagnosed as having liver carcinoma for 2 years presented with a 2-month history of multiple papulonodules on the face, ears, neck, and upper chest, accompanied by progressive polyarthralgia of the hands, wrists, elbows and knee joints without fever or chills. Skin histology revealed well defined dermal infiltrate consisting of multinucleated giant cells and macrophages having abundant eosinophilic finely granular cytoplasm with ground glass appearance. Further immunohistochemical studies characterized the lesions as positive for CD68, CD45 and Vimentin. A diagnosis of MRH that was associated with liver cancer was made. Treatment with prednisolone for 2 months resulted in a significant improvement of the skin and joint symptoms, but was discontinued due to his significant enlargement and extensive metastases of the liver carcinoma.
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Mei
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Xia
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Quan-Shui
authors.initials: QS
authors.lastname: Hao
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Cheng
authors.affiliation: Hubei Huanggang Central Hospital Huanggang 438000, Hubei Province, China.
authors.forename: Yao-Hua
authors.initials: YH
authors.lastname: Wu
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018771:Arthralgia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001706:Biopsy; D002277:Carcinoma / Q000150:complications* / Q000175:diagnosis; D004890:Erythema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use*; D015614:Histiocytosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000032:analysis; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012074:Remission Induction; D012867:Skin / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D005938:Glucocorticoids; D017493:Leukocyte Common Antigens; D011239:Prednisolone; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C516769:PTPRC protein, human
keywords: Multicentric reticulohistiocytosis; liver cancer; malignancy