title: Pressure changes within the sac of human cerebral aneurysms in response to artificially induced transient increases in systemic blood pressure.
abstract: Formation and rupture of cerebral aneurysms have been associated with chronic hypertension. The effect of transient increase in blood pressure and its effect on intra-aneurysmal hemodynamics have not been studied. We examined the effects of controlled increases in blood pressure on different pressure parameters inside the sac of human cerebral aneurysms and corresponding parent arteries using invasive technology. Twelve patients (10 female, 2 male, age 54±15 years) with unruptured cerebral aneurysms undergoing endovascular coiling were recruited. Dual-sensor microwires with the capacity to simultaneously measure flow velocity and pressure were used to measure systolic, diastolic, and mean pressure inside the aneurysm sac and to measure both pressures and flow velocities in the feeder vessel just outside the aneurysm. These pressures were recorded simultaneously with pressures from a radial arterial catheter. Measurements were taken at baseline and then during a gradual increase in systemic systolic blood pressure to a target value of ≈25 mm Hg above baseline, using a phenylephrine infusion. The dose needed to achieve the required increase in radial arterial systolic blood pressure was 0.8±0.2 μg/kg/min. There was a clear linear relationship between changes in radial and aneurysmal pressures with substantial patient-by-patient variation in the slopes of those relationships. The overall increases in systolic and mean pressures in both radial artery and in the aneurysms were similar. Pressures in the aneurysm and in the parent vessels were similar. Peak and mean flow velocities in the parent arteries did not change significantly with phenylephrine infusion, nor did vessel diameters as measured angiographically.
authors.affiliation: From the Department of Neurosurgery (D.M.H) and Department of Anesthesia (B.J.H., M.M.T.), University of Iowa Carver College of Medicine, Iowa City. david-hasan@uiowa.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Hasan
authors.affiliation: From the Department of Neurosurgery (D.M.H) and Department of Anesthesia (B.J.H., M.M.T.), University of Iowa Carver College of Medicine, Iowa City.
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Hindman
authors.affiliation: From the Department of Neurosurgery (D.M.H) and Department of Anesthesia (B.J.H., M.M.T.), University of Iowa Carver College of Medicine, Iowa City.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Todd
mesh_terms: D000328:Adult; D000368:Aged; D062186:Arterial Pressure / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D057510:Endovascular Procedures; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D064887:Observational Studies as Topic; D010656:Phenylephrine / Q000494:pharmacology; D011446:Prospective Studies; D017534:Radial Artery / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D010656:Phenylephrine
keywords: blood pressure; diastole; intracranial aneurysm; phenylephrine; pulse pressure