title: 99Tcm-MDP Imaging of Osteopetrosis: Case Report.
abstract: Osteopetrosis, also known as marble bone disease, is a clinically rare genetic disease, which represents a heterogeneous group of rare, inherited bone dysplasias that share the hallmark of abnormally increased bone density caused by osteoclast dysfunction. Hereby, the authors describe a case of osteopetrosis that showed increased diffuse radioactive uptake on whole body bone (99)Tc(m)-methylene diphosphonate imaging in a 56-year-old man, which increased universal radioactive uptake on craniofacial bone imaging, and enlargement of the limb long bone near the joints with evenly symmetrical enriched distribution of radioactivity. Osteopetrosis was made which based on these features and characteristics shown on (99)Tc(m)-MDP imaging.Skeletal scintigraphy with Tc-methylene diphosphonate imaging is helpful to the diagnosis of osteopetrosis. There is a characteristic of osteopetrosis different from other bone metabolic diseases.
authors.affiliation: From the Department of Nuclear Medicine, Department of ultrasound, Tangshan Gongren Hospital, Tangshan, Hebei Province, China.
authors.forename: Li-Chun
authors.initials: LC
authors.lastname: Zheng
authors.forename: Xiang-Liu
authors.initials: XL
authors.lastname: OuYang
authors.forename: Gui-Chao
authors.initials: GC
authors.lastname: Liu
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhang
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D010022:Osteopetrosis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate