title: Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series.
abstract: Published studies, taken together, suggest the existence of a single canine lymphoma entity, with a small clear cell appearance by cytological evaluation, a histopathological T-zone pattern and an aberrant CD45-negative T-cell phenotype, mostly characterized by long-term survival. We describe clinical presentation and outcome in a retrospective case series of canine small clear cell/T-zone lymphoma. Despite the reported predisposition of Golden retriever, this breed was not represented in our case series. Most dogs presented with stage V disease, whereas only few had clinical signs or peripheral cytopenias. Blood was almost always more infiltrated than bone marrow. Median survival confirmed the favourable prognosis described in literature, but a few dogs died within a short time. Also, a subgroup of dogs developed second malignancies, eventually leading to death. We did not investigate possible prognostic factors because of the wide variety in treatments, and further studies are needed to identify high-risk animals.
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, Milan, Italy.
authors.forename: V
authors.identifier: http://orcid.org/0000-0002-9882-2867
authors.initials: V
authors.lastname: Martini
authors.affiliation: Centro Oncologico Veterinario, Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Marconato
authors.affiliation: Department of Veterinary Science, University of Turin, Turin, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Poggi
authors.affiliation: Department of Veterinary Science, University of Turin, Turin, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Riondato
authors.affiliation: Department of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Aresu
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cozzi
authors.affiliation: Department of Veterinary Sciences and Public Health, University of Milan, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Comazzi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000097:blood* / Q000473:pathology*; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000096:biosynthesis* / Q000097:blood; D016399:Lymphoma, T-Cell / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008499:Medical Records; D009367:Neoplasm Staging / Q000662:veterinary; D011379:Prognosis; D012189:Retrospective Studies; D013534:Survival
chemical_list: D017493:Leukocyte Common Antigens
keywords: CD45-negative; T-zone; clinical presentation; lymphoma; outcome; small clear cell