title: Abscisic acid induces biosynthesis of bisbibenzyls and tolerance to UV-C in the liverwort Marchantia polymorpha.
abstract: Environmental stresses are effective triggers for the biosynthesis of various secondary metabolites in plants, and phytohormones such as jasmonic acid and abscisic acid are known to mediate such responses in flowering plants. However, the detailed mechanism underlying the regulation of secondary metabolism in bryophytes remains unclear. In this study, the induction mechanism of secondary metabolites in the model liverwort Marchantia polymorpha was investigated. Abscisic acid (ABA) and ultraviolet irradiation (UV-C) were found to induce the biosynthesis of isoriccardin C, marchantin C, and riccardin F, which are categorized as bisbibenzyls, characteristic metabolites of liverworts. UV-C led to the significant accumulation of ABA. Overexpression of MpABI1, which encodes protein phosphatase 2C (PP2C) as a negative regulator of ABA signaling, suppressed accumulation of bisbibenzyls in response to ABA and UV-C irradiation and conferred susceptibility to UV-C irradiation. These data show that ABA plays a significant role in the induction of bisbibenzyl biosynthesis, which might confer tolerance against UV-C irradiation in M. polymorpha.
authors.affiliation: Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
authors.forename: Akito
authors.initials: A
authors.lastname: Kageyama
authors.affiliation: Graduate School of Science, Kobe University, Kobe 657-8501, Japan.
authors.forename: Kimitsune
authors.initials: K
authors.lastname: Ishizaki
authors.affiliation: Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kohchi
authors.affiliation: Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
authors.affiliation: Research Faculty of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. Electronic address: kosaku@chem.agr.hokudai.ac.jp.
authors.forename: Kosaku
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism* / Q000494:pharmacology; D001632:Bibenzyls / Q000378:metabolism*; D002396:Catechols / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004988:Ethers, Cyclic / Q000378:metabolism; D047008:Marchantia / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D010647:Phenyl Ethers / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D030821:Plants, Genetically Modified / Q000187:drug effects / Q000528:radiation effects; D064210:Secondary Metabolism; D013312:Stress, Physiological; D014466:Ultraviolet Rays
chemical_list: D001632:Bibenzyls; D002396:Catechols; D004988:Ethers, Cyclic; D010647:Phenyl Ethers; D010940:Plant Proteins; C459128:isoriccardin C; C459129:marchantin C; C572113:riccardin F; D000040:Abscisic Acid; D010749:Phosphoprotein Phosphatases
keywords: Abscisic acid; Bisbibenzyl; Common liverwort; Marchantia polymorpha; Marchantiophyta; Secondary metabolite; UV-C irradiation