title: A new cyclic bisdesmoside from Actinostemma lobatum Maxim.
abstract: A new cyclic bisdesmoside treterpene saponin, lobatoside N (1), together with four known triterpenoids, was isolated from the herb of Actinostemma lobatum Maxim. Structures were established by means of extensive spectral data analysis. Furthermore, the cytotoxic activities of the identified compounds were evaluated using HCT-116, HT-29, MCF-7 and A549 human cancer cell lines. As a result, compounds 1-5 showed significant cytotoxicities in a dose-dependent manner against the cell lines tested. Especially, compound 5 exhibited stronger activities, with IC50 value of 0.88 μM and 0.98 μM, than that of the positive control drug (Cis-platinum) against HT-29 and A549 cell lines.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Cao
authors.forename: Li
authors.initials: L
authors.lastname: Wei
authors.forename: Yun
authors.initials: Y
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D004396:Coloring Agents; D019662:Cucurbitaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D012503:Saponins; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes; C511987:bisdesmoside; C000601311:lobatoside N; C022616:thiazolyl blue; D002945:Cisplatin