title: Fundamental limits on the accuracy of demographic inference based on the sample frequency spectrum.
abstract: The sample frequency spectrum (SFS) of DNA sequences from a collection of individuals is a summary statistic that is commonly used for parametric inference in population genetics. Despite the popularity of SFS-based inference methods, little is currently known about the information theoretic limit on the estimation accuracy as a function of sample size. Here, we show that using the SFS to estimate the size history of a population has a minimax error of at least O(1/log s), where s is the number of independent segregating sites used in the analysis. This rate is exponentially worse than known convergence rates for many classical estimation problems in statistics. Another surprising aspect of our theoretical bound is that it does not depend on the dimension of the SFS, which is related to the number of sampled individuals. This means that, for a fixed number s of segregating sites considered, using more individuals does not help to reduce the minimax error bound. Our result pertains to populations that have experienced a bottleneck, and we argue that it can be expected to apply to many populations in nature.
authors.affiliation: Department of Statistics, University of California, Berkeley, CA 94720;
authors.forename: Jonathan
authors.initials: J
authors.lastname: Terhorst
authors.affiliation: Department of Statistics, University of California, Berkeley, CA 94720; Computer Science Division, University of California, Berkeley, CA 94720; Department of Integrative Biology, University of California, Berkeley, CA 94720 yss@berkeley.edu.
authors.forename: Yun S
authors.initials: YS
authors.lastname: Song
mesh_terms: D004247:DNA / Q000235:genetics; D003710:Demography; D006801:Humans; D008962:Models, Theoretical
chemical_list: D004247:DNA
keywords: demographic inference; minimax rate; population genetics