title: Quality of life is associated with chronic inflammation in schizophrenia: a cross-sectional study.
abstract: Inflammation may play a crucial role in the pathogenesis of schizophrenia. However, the association between chronic inflammation and health outcomes in schizophrenia remains unclear, particularly for patient-reported outcomes. The aim of this study was to investigate the relationship between quality of life (QoL) and chronic inflammation assessed using C -Reactive Protein (CRP) in patients with schizophrenia. Two hundred and fifty six patients with schizophrenia were enrolled in this study. After adjusting for key socio-demographic and clinical confounding factors, patients with high levels of CRP (>3.0 mg/l) had a lower QoL than patients with normal CRP levels (OR = 0.97, 95% CI = 0.94-0.99). An investigation of the dimensions of QoL revealed that psychological well-being, physical well-being and sentimental life were the most salient features of QoL associated with CRP. Significant associations were found between lower educational level (OR = 4.15, 95% CI = 1.55-11.07), higher body mass index (OR = 1.16, 95% CI = 1.06-1.28), higher Fagerström score (OR = 1.22, 95% CI = 1.01-1.47) and high levels of CRP. After replications with longitudinal approaches, the association between QoL and chronic inflammation may offer interesting interventional prospects to act both on inflammation and QoL in patients with schizophrenia.
authors.affiliation: 1] Department of Psychiatry, La Conception University Hospital, 13009 Marseille, France [2] Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Faugere
authors.affiliation: 1] Department of Clinical Neurophysiology, Sleep Clinique, Pellegrin University Hospital, 33076 Bordeaux, France [2] Bordeaux University, USR CNRS 3413 SANPSY, Research Unit, 33000 Bordeaux, France.
authors.forename: J A
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Alessandrini
authors.affiliation: 1] Department of Psychiatry, La Conception University Hospital, 13009 Marseille, France [2] Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: R
authors.initials: R
authors.lastname: Richieri
authors.affiliation: 1] Department of Psychiatry, La Conception University Hospital, 13009 Marseille, France [2] Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Faget-Agius
authors.affiliation: Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Auquier
authors.affiliation: 1] Department of Psychiatry, La Conception University Hospital, 13009 Marseille, France [2] Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Lançon
authors.affiliation: Aix-Marseille Univ., EA 3279 - Public Health, Chronic Diseases and Quality of Life - Research Unit, 13005 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Boyer
mesh_terms: D000328:Adult; D002097:C-Reactive Protein; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein