title: CTCF as a multifunctional protein in genome regulation and gene expression.
abstract: CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator protein, blocking the communication between enhancers and promoters. CTCF can also recruit other transcription factors while bound to chromatin domain boundaries. The three-dimensional organization of the eukaryotic genome dictates its function, and CTCF serves as one of the core architectural proteins that help establish this organization. The mapping of CTCF-binding sites in diverse species has revealed that the genome is covered with CTCF-binding sites. Here we briefly describe the diverse roles of CTCF that contribute to genome organization and gene expression.
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.
authors.forename: Somi
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.
authors.forename: Nam-Kyung
authors.initials: NK
authors.lastname: Yu
authors.affiliation: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea.
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
mesh_terms: D000818:Animals; D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D011485:Protein Binding; D060066:Protein Interaction Maps; D012097:Repressor Proteins / Q000032:analysis / Q000378:metabolism*; D000097722:Cohesins
chemical_list: D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D012097:Repressor Proteins; D000097722:Cohesins; C000619697:CTCF protein, human