title: In vivo imaging methods to assess glaucomatous optic neuropathy.
abstract: The goal of this review is to summarize the most common imaging methods currently applied for in vivo assessment of ocular structure in animal models of experimental glaucoma with an emphasis on translational relevance to clinical studies of the human disease. The most common techniques in current use include optical coherence tomography and scanning laser ophthalmoscopy. In reviewing the application of these and other imaging modalities to study glaucomatous optic neuropathy, this article is organized into three major sections: 1) imaging the optic nerve head, 2) imaging the retinal nerve fiber layer and 3) imaging retinal ganglion cell soma and dendrites. The article concludes with a brief section on possible future directions.
authors.affiliation: Discoveries in Sight Research Laboratories, Devers Eye Institute and Legacy Research Institute, Legacy Health, 1225 NE Second Avenue, Portland, OR 97232, USA. Electronic address: bfortune@deverseye.org.
authors.forename: Brad
authors.initials: B
authors.lastname: Fortune
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005901:Glaucoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D012165:Retinal Ganglion Cells / Q000473:pathology*
keywords: Adaptive optics; Experimental models; Glaucoma; Optic nerve; Optical coherence tomography; Retinal ganglion cells; Retinal nerve fiber layer; Scanning laser ophthalmoscopy; Scanning laser polarimetry