title: Successful treatment by coil embolization for infantile hemangioma with Kasabach-Meritt syndrome of newborn.
abstract: Infantile hemangioma (IH) is the most common tumor of infancy, and it sometimes associated with Kasabach-Meritt syndrome (KMS) characterized by anemia, intraperitoneal hemorrhage secondary to rupture, coagulopathy, jaundice, and vascular malformations involving the brain, skin, gut, and other organs. Here, we report two newborn patients having IH with KMS at birth. The first patient had a giant hemangioma in the liver, which was successfully treated with i.v. corticosteroid and coil embolization. The second patient had a large hemangioma of the right axillary region, which was also successfully treated with i.v. corticosteroid, beta-blocker, coil embolization and local irradiation. All symptoms were controlled without any side-effects in both patients. According to these findings, combination therapy including coil embolization and corticosteroid is effective for IH patients with KMS. The indications for and timing of coil embolization should be determined further cases have been accumulated.
authors.affiliation: Division of Pediatrics, Ehime Prefectural Central Hospital, Matsuyama, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Tezuka
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ohta
authors.affiliation: Division of Pediatrics, Yawatahama City General Hospital, Yawatahama, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ochi
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Chisaka
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Higaki
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Ehime, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D000792:Angiography; D001365:Axilla; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006391:Hemangioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D059885:Kasabach-Merritt Syndrome / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016216:Ultrasonography, Prenatal
chemical_list: D005938:Glucocorticoids
keywords: Kasabach-Meritt syndrome; coil embolization; corticosteroid; infantile hemangioma