title: Prospective study of body fat distribution and the risk of endometrial cancer.
abstract: BACKGROUND
  Epidemiologic studies have found that overall obesity is positively related to endometrial cancer (EC) risk. However, data assessing the association between body fat distribution and risk of EC are still limited.
  
  
  METHODS
  We followed 51,948 women who first reported waist circumference (WC) and hip circumference in 1986 in the Nurses' Health Study. Waist-to-hip ratio (WHR) was calculated.
  
  
  RESULTS
  During 24 years of follow-up, 449 incident invasive EC cases were diagnosed. In a multivariate analysis without adjusting for body mass index (BMI), the relative risks (RRs) for EC comparing extreme categories were 2.44 (95% confidence interval [CI] 1.72-3.45) for WC and 1.69 (95% CI=1.20-2.40) for WHR. However, after adjustment of BMI, those positive associations were substantially attenuated and no longer significant; RR=1.08 (95% CI=0.69-1.67) for WC and 1.15 (95% CI=0.81-1.64) for WHR, respectively.
  
  
  CONCLUSIONS
  In our prospective cohort study, we found no independent association between body fat distribution and the risk of EC after adjustment for BMI.
authors.affiliation: Department of Obstetrics and Gynecology.|Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Woong
authors.initials: W
authors.lastname: Ju
authors.affiliation: Division of Health and Nutrition Survey, Korea Centers for Disease Control and Prevention, Cheongju-si, Republic of Korea.
authors.forename: Hyun Ja
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.|Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Hankinson
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.|Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
authors.forename: Immaculata
authors.initials: I
authors.lastname: De Vivo
authors.affiliation: Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.|Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI.|Department of Epidemiology, Brown School of Public Health, Providence, RI.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050218:Body Fat Distribution; D015992:Body Mass Index; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D011446:Prospective Studies; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio
keywords: Body fat distribution; Endometrial cancer; Prospective cohort study