title: Effect of Capparis spinosa extract on sutural ossification: A stereological study.
abstract: OBJECTIVE
  To investigate the effects of systemically administered Capparis spinosa extract (CSE) on expanded sutures in rats via three dimensionally morphometric method (stereological method).
  
  
  METHODS
  Thirty-two Wistar rats were used. Subjects were divided into four groups, each with eight rats. Orthopaedic expansion force was applied for 5 days to maxillary incisors by attaching springs. Control-1 and CSE-1 waited 1 week for consolidation, and Control-2 and CSE-2 waited 2 weeks for consolidation. After the consolidation period, the subjects were sacrificed. Stereological examination was performed to determine the volume and area of new bone, connective tissue, and capillaries.
  
  
  RESULTS
  New bone area, new bone volume, connective tissue space, and connective tissue volume were statistically different in CSE-1 compared to Control-1. But there were no statistically difference between CSE-2 and Control_2. In terms of the volume of blood vessels and vascular area, there were no statistically significant differences when comparing Groups CSE-1 and Control-1 or CSE-2 and Control-2.
  
  
  CONCLUSIONS
  Systemic use of CSE accelerated fastened osteoblastic activity in the early period.
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey. Electronic address: mserifkhan@gmail.com.
authors.forename: Muharrem Serif
authors.initials: MS
authors.lastname: Erdogan
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Babacan
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey.
authors.forename: M Isa
authors.initials: MI
authors.lastname: Kara
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey.
authors.forename: Birol
authors.initials: B
authors.lastname: Gurler
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Akgul
authors.affiliation: Izmir Katip Celebi University, Department of Orthodontics, Faculty of Dentistry, İzmir 35640, Turkey.
authors.forename: Durmus Ali
authors.initials: DA
authors.lastname: Soyler
mesh_terms: D000818:Animals; D031484:Capparis; D003238:Connective Tissue / Q000187:drug effects; D003393:Cranial Sutures / Q000187:drug effects*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D010155:Palatal Expansion Technique; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts
keywords: Capparis spinosa; Osteogenesis; Rapid maxillar expansion; Stereological