title: CAD/CAM-fabricated implant-supported restorations: a systematic review.
abstract: OBJECTIVE
  The aim of this systematic review was to identify and summarize the available literature related to CAD/CAM-fabricated implant-supported restorations.
  
  
  METHODS
  A systematic review of the literature was conducted using the Cochrane Library and the US Library of Medicine, National Institute of Health databases (Pubmed). Several search runs with specific search terms were performed and combined. All published papers available on the databases up to January 15, 2015 were considered with primarily no restrictions.
  
  
  RESULTS
  About 12 of 3484 identified papers met the inclusion criteria and were analyzed in the present review. One paper reported results on implant-supported single crowns (SCs), one on partial fixed dental prostheses (FDPs), and 10 papers reported results on full-arch screw-retained FDPs. Publications on SCs and FDPs were very limited but it was possible to identify 10 papers reporting adequate results on full-arch screw-retained FDPs. Survival rates ranged between 92% and 100% with observation times of 1-10 years.
  
  
  CONCLUSIONS
  The available data provided promising results for CAD/CAM-fabricated implant-supported restorations; nonetheless, current evidence is limited due to the quality of available studies and the paucity of data on long-term clinical outcomes of 5 years or more. In the sense of an evidence-based dentistry, the authors recommend further studies designed as randomized controlled clinical trials and reported according to the CONSORT statement.
authors.affiliation: Department of Prosthetic Dentistry, Center for Dental Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
authors.forename: Sebastian Berthold Maximilian
authors.initials: SB
authors.lastname: Patzelt
authors.affiliation: Department of Prosthetic Dentistry, Center for Dental Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
authors.forename: Benedikt C
authors.initials: BC
authors.lastname: Spies
authors.affiliation: Department of Prosthetic Dentistry, Center for Dental Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
authors.forename: Ralf J
authors.initials: RJ
authors.lastname: Kohal
mesh_terms: D017076:Computer-Aided Design; D003442:Crowns; D017267:Dental Prosthesis Design / Q000379:methods*; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D003830:Denture, Partial, Fixed; D055094:Evidence-Based Dentistry; D006801:Humans
keywords: CAD-CAM; Computer-aided design; dental implant; implant-supported dental prosthesis