title: Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease.
abstract: The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease.
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: H
authors.initials: H
authors.lastname: Trimarchi
authors.affiliation: Laboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Canzonieri
authors.affiliation: Laboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Muryan
authors.affiliation: Laboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Schiel
authors.affiliation: IFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina.
authors.forename: A
authors.identifier: 0000-0003-4085-2307
authors.initials: A
authors.lastname: Araoz
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Forrester
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Karl
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Lombi
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Andrews
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Pomeranz
authors.affiliation: Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
authors.forename: T
authors.initials: T
authors.lastname: Rengel
authors.affiliation: IFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Zotta