title: Platinum hypersensitivity and desensitization.
abstract: Platinum agents are drugs used for various types of cancer. With increased frequency of administration of platinum agents, hypersensitivity reactions appear more frequently, occurring in over 25% of cases from the seventh cycle or second line onward. It then becomes difficult to conduct treatment using these agents. Various approaches have been investigated to address hypersensitivity reactions to platinum agents. Desensitization, which gradually increases the concentration of the anticancer drug considered to be the antigen until the target dosage, has been reported as being particularly effective, with a success rate of 80-100%. The aims of this paper are to present the current findings regarding hypersensitivity reactions to platinum agents and to discuss attempts of using desensitization against hypersensitivity reactions worldwide.
authors.affiliation: Department of Medical Oncology, Japanese Red Cross Medical Center, Shibuya, Tokyo aaa17580@pop06.odn.ne.jp.
authors.forename: Shingo
authors.initials: S
authors.lastname: Miyamoto
authors.affiliation: Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, Shibuya, Tokyo.
authors.forename: Rika
authors.initials: R
authors.lastname: Okada
authors.affiliation: Department of Gynecology, Japanese Red Cross Medical Center, Shibuya, Tokyo, Japan.
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Ando
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003888:Desensitization, Immunologic; D003907:Dexamethasone / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D003907:Dexamethasone
keywords: desensitization; hypersensitivity; platinum