title: Acute renal failure after high-dose antibiotic bone cement: case report and review of the literature.
abstract: High-dose antibiotic-loaded bone cement (ALBC) spacers are commonly used to treat prosthetic joint infections following total hip and knee arthroplasties. This methodology can provide high local antibiotic concentrations while minimizing systemic exposure and toxicity. The occurrence of acute kidney injury (AKI) is rarely reported. Available literature suggests that the rate may be higher than previously thought. We report a case of significant systemic tobramycin absorption with concomitant acute renal failure in a 69-year-old female following the implantation of a high-dose ALBC spacer containing both tobramycin and vancomycin. The tobramycin level 24 h post-surgery was 5.8 mcg/mL. Due to concomitant renal failure, antibiotic clearance was poor and resulted in prolonged exposure to elevated aminoglycoside levels. Recovery of renal function occurred, but clinicians should be vigilant in considering the potential impact ALBC spacers can have on post-operative renal function if antibiotic elution is higher than expected.
authors.affiliation: a Banner Health , Mesa , AZ , USA.
authors.forename: Alexia
authors.initials: A
authors.lastname: James
authors.affiliation: a Banner Health , Mesa , AZ , USA.
authors.forename: Trent
authors.initials: T
authors.lastname: Larson
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects* / Q000379:methods; D001806:Blood Urea Nitrogen; D001843:Bone Cements / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D018570:Risk Assessment; D014031:Tobramycin / Q000009:adverse effects* / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D014031:Tobramycin
keywords: Acute kidney injury; arthroplasty; bone cement; knee; prosthesis-related infections; replacement; tobramycin/adverse effects