title: Prognostic factors of laryngeal solitary extramedullary plasmacytoma: a case report and review of literature.
abstract: A paucity of data exists concerning the presentation, natural course and outcome of extramedullary plasmcytoma (EMP). It is difficult to determine the optimal treatment strategy and prognostic factors for EMP. We present an additional case of laryngeal EMP and systemic review relevant reports in the English and Chinese literature. We found, to our knowledge, 147 cases in larynx in the English-language literature and Chinese-literature. The most common treatment modality was radiotherapy alone. The mean survival duration was ~184 months, and the 5- and 10- year survival rates were 76.1% and 67.4%, respectively. The univariate analysis suggested that progression to multiple myeloma and amyloid deposits may be poor prognostic factors. The multivariate analysis suggested that only progression to multiple myeloma may be a poor prognostic factor. Laryngeal EMP is uncommon. Progression to multiple myeloma may be a poor prognostic factor.
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China ; Department of Otolaryngology, The First people's Hospital of Yongkang City Yongkang 321302, Zhejiang Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Min-Li
authors.initials: ML
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Shui-Hong
authors.initials: SH
authors.lastname: Zhou
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Bao
authors.affiliation: Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Qin-Ying
authors.initials: QY
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Zhejiang University College of Medicine Hangzhou 310003, China.
authors.forename: Zhou-Jun
authors.initials: ZJ
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000628:therapy; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000737:chemistry / Q000175:diagnosis / Q000628:therapy; D015999:Multivariate Analysis; D010954:Plasmacytoma / Q000737:chemistry / Q000175:diagnosis / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D049489:Stroboscopy; D013997:Time Factors; D014139:Tracheostomy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Extramedullary plasmcytoma; amyloid deposits; larynx; prognosis; progression to multiple myeloma