title: Regulation of cough by neuronal Na(+)-K(+) ATPases.
abstract: The Na(+)-K(+) ATPases play an essential role in establishing the sodium gradients in excitable cells. Multiple isoforms of the sodium pumps have been identified, with tissue and cell specific expression patterns. Because the vagal afferent nerves regulating cough must be activated at sustained high frequencies of action potential patterning to achieve cough initiation thresholds, it is a certainty that sodium pump function is essential to maintaining cough reflex sensitivities in health and in disease. The mechanisms by which Na(+)-K(+) ATPases regulate bronchopulmonary vagal afferent nerve excitability are reviewed as are potential therapeutic strategies targeting the sodium pumps in cough.
authors.affiliation: The Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA. Electronic address: bjc@jhmi.edu.
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Canning
authors.affiliation: Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: David G S
authors.initials: DG
authors.lastname: Farmer
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology; D003371:Cough / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D058990:Molecular Targeted Therapy; D009475:Neurons, Afferent / Q000502:physiology; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D000996:Antitussive Agents; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase