title: Emerging developments in the use of bioactive glass for reconstruction of craniofacial bone.
abstract: For decades, researchers have investigated the use of bioactive glasses as synthetic substitutes for bone grafts that can bond with bone, and recent discoveries have shown that their clinical performance in osteoplastic and reconstructive surgery has exceeded that of traditional synthetic materials. Craniofacial reconstructions with bioactive glass were associated with good functional and aesthetic results with no donor-site morbidity, and the material's unique ability to inhibit bacterial growth was advantageous when used in dead spaces that were chronically infected. Treatment of large defects in the head and neck with these multifunctional biomaterials is a suitable alternative to conventional methods.
authors.affiliation: King's College Hospital NHS Foundation Trust, Department of Oral and Maxillofacial Surgery, Denmark Hill, London SE5 9RS, UK; Friedrich-Schiller-University Jena, Otto Schott Institute of Materials Research (OSIM), Fraunhoferstr. 6, D-07743 Jena, Germany. Electronic address: andrea.profeta@kcl.ac.uk.
authors.forename: A C
authors.initials: AC
authors.lastname: Profeta
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use*; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use*; D016025:Bone Transplantation; D003188:Composite Resins; D005145:Face / Q000601:surgery*; D005147:Facial Bones / Q000601:surgery*; D005898:Glass / Q000737:chemistry; D006801:Humans; D019904:Polymethyl Methacrylate; D019651:Plastic Surgery Procedures; D012886:Skull / Q000000981:diagnostic imaging / Q000601:surgery*; D014945:Wound Healing; D014946:Wound Infection / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D018786:Bone Substitutes; D003188:Composite Resins; D019904:Polymethyl Methacrylate
keywords: Alloplastic grafting materials; Bioactive glass; Osteoplastic and reconstructive surgery