title: Biotransformation of 20(S)-protopanaxatriol by Mucor racemosus and the anti-cancer activities of some products.
abstract: OBJECTIVE
  To produce new derivatives of 20(S)-protopanaxatriol by fungal biotransformation.
  
  
  RESULTS
  Biotransformation of 20(S)-protopanaxatriol (1) by Mucor racemosus AS 3.205 afforded six products. Their structures were elucidated on the basis of extensive spectroscopic analyses. M. racemosus could selectively catalyze dehydrogenation at C-12 and further hydroxylation at C-7, C-11, and C-15, as well as rearrangement of double bond at C-26. Two of these new compounds exhibited potent inhibitory activity against SH-SY5Y and HepG2 cell lines.
  
  
  CONCLUSIONS
  Biotransformation by M. racemosus AS 3.205 was an effective approach to produce new derivatives of 20(S)-protopanaxatriol.
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China. g.chen@infu.tu-dortmund.de.|Faculty of Chemistry and Chemical Biology, Institute of Environmental Research (INFU), TU Dortmund, 44221, Dortmund, Germany. g.chen@infu.tu-dortmund.de.
authors.forename: Guangtong
authors.initials: G
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ge
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Zhai
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China. xiang.nantong@gmail.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Ling
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001711:Biotransformation; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009089:Mucor / Q000378:metabolism*; D012502:Sapogenins / Q000378:metabolism*; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D012502:Sapogenins; C081552:protopanaxatriol
keywords: 20(S)-Protopanaxatriol; Anti-cancer compounds; Biocatalysis; Biotransformation; Cytotoxic activity; Dehydrogenation; Mucor racemosus