title: Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load.
abstract: Sleep has important homeostatic functions, and circadian rhythms organize physiology and behavior on a daily basis to insure optimal function. Sleep deprivation and circadian disruption can be stressors, enhancers of other stressors that have consequences for the brain and many body systems. Whether the origins of circadian disruption and sleep disruption and deprivation are from anxiety, depression, shift work, long-distance air travel, or a hectic lifestyle, there are consequences that impair brain functions and contribute to the cumulative wear and tear on body systems caused by too much stress and/or inefficient management of the systems that promote adaptation.
authors.affiliation: Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: mcewen@mail.rockefeller.edu.
authors.forename: Bruce S
authors.initials: BS
authors.lastname: McEwen
authors.affiliation: Department of Integrative Physiology and Neuroscience, Washington State University, 1815 Ferdinand's Lane, Pullman, WA 99164-6520, USA.
authors.forename: Ilia N
authors.initials: IN
authors.lastname: Karatsoreos
mesh_terms: D052636:Allostasis / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D019964:Mood Disorders / Q000503:physiopathology; D012892:Sleep Deprivation / Q000503:physiopathology* / Q000523:psychology; D013315:Stress, Psychological / Q000503:physiopathology*
keywords: Allostasis; Allostatic load; Circadian disruption; Glycogen; Hippocampus; Oxidative stress; Pro-inflammatory cytokines; Sleep deprivation