title: Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines.
abstract: The first general palladium-catalyzed, enantioselective three-component synthesis of α-arylamines starting from sulfonamides, aldehydes, and arylboronic acids has been developed. These reactions generate a wide array of α-arylamines with high yields and enantioselectivities. Notably, this process is tolerant to air and moisture, providing an operationally simple approach for the synthesis of chiral α-arylamines.
authors.affiliation: Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors.forename: Tamara
authors.initials: T
authors.lastname: Beisel
authors.affiliation: Department of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Manolikakes
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D001897:Boronic Acids; D013449:Sulfonamides; D010165:Palladium