title: Vitamin D status and health-related quality of life in patients with Type 2 diabetes.
abstract: OBJECTIVE
  To test whether vitamin D status was associated with health-related quality of life in people with Type 2 diabetes mellitus.
  
  
  METHODS
  Demographic and clinical characteristics, including health-related quality of life scores, were obtained from 241 adult patients with Type 2 diabetes managed with oral hypoglycaemic agents. Health-related quality of life was assessed using the Short-Form 36 Health Survey. Multiple logistic regression analysis was used to investigate the association between vitamin D status and health-related quality of life, with adjustment for confounders.
  
  
  RESULTS
  The mean age of the patients included in the study was 67 ± 8 years. Their mean HbA1c concentration was 52 ± 8 mmol/mol (6.9 ± 0.7%) and their mean serum 25-hydroxyvitamin D concentration was 59 ± 23 nmol/l. Vitamin D deficiency (serum 25-hydroxyvitamin D < 50 nmol/l) was present in 38% of patients. No significant associations were found between vitamin D status and health-related quality of life.
  
  
  CONCLUSIONS
  Vitamin D status was not associated with health-related quality of life in patients with Type 2 diabetes. This could be explained by the relatively high serum 25-hydroxyvitamin D concentration, good glycaemic control and relatively good health-related quality of life of all patients. A prospective study among patients with vitamin D deficiency and poor glycaemic control would be interesting for future research.
authors.affiliation: Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, The Netherlands.
authors.forename: Y H M
authors.initials: YH
authors.lastname: Krul-Poel
authors.affiliation: Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Westra
authors.affiliation: Department of General Practice, DIAZON, Alkmaar, The Netherlands.
authors.forename: H J J
authors.initials: HJ
authors.lastname: van Wijland
authors.affiliation: Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Stam
authors.affiliation: Department of Internal Medicine/Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Lips
authors.affiliation: Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Pouwer
authors.affiliation: Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, The Netherlands.|Department of Internal Medicine/Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Simsek
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status / Q000502:physiology*; D011788:Quality of Life; D014807:Vitamin D / Q000097:blood* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy
chemical_list: D007004:Hypoglycemic Agents; D014807:Vitamin D