title: Experimentally Induced Mammalian Models of Glaucoma.
abstract: A wide variety of animal models have been used to study glaucoma. Although these models provide valuable information about the disease, there is still no ideal model for studying glaucoma due to its complex pathogenesis. Animal models for glaucoma are pivotal for clarifying glaucoma etiology and for developing novel therapeutic strategies to halt disease progression. In this review paper, we summarize some of the major findings obtained in various glaucoma models and examine the strengths and limitations of these models.
authors.affiliation: Department of Ophthalmology, Akita Graduate University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
authors.forename: Makoto
authors.identifier: 0000-0002-1808-1799
authors.initials: M
authors.lastname: Ishikawa
authors.affiliation: Department of Ophthalmology, Akita Graduate University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshitomi
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA ; The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Zorumski
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA ; The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Izumi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005901:Glaucoma / Q000235:genetics / Q000503:physiopathology*; D000882:Haplorhini; D006801:Humans; D007834:Lasers; D008028:Light Coagulation; D008322:Mammals; D051379:Mice; D011817:Rabbits; D051381:Rats; D012165:Retinal Ganglion Cells / Q000473:pathology* / Q000528:radiation effects