title: An updated role of microRNA-124 in central nervous system disorders: a review.
abstract: MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
authors.forename: Zhu-Min
authors.initials: ZM
authors.lastname: Luo
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
authors.forename: Xiu-Ming
authors.initials: XM
authors.lastname: Guo
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
authors.forename: Ding-Feng
authors.initials: DF
authors.lastname: Su
authors.affiliation: Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
keywords: CNS disorders; CNS stress; brain development; brain tumor; microRNA-124; neurodegradation; neuroimmunity; stroke