title: MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression.
abstract: Breast cancer is one of the most common malignancies and a major cause of cancer-related mortality all over the world. A growing body of reports revealed that microRNAs play essential roles in the progression of cancers. Aberrant expression of miR-503 has been reported in several kinds of cancer. The aim of the current study was to elucidate the role of miR-503 in the pathogenesis of breast cancer. In the present study, our results suggested that miR-503 expression was markedly downregulated in breast cancer tissues and cells. Overexpression of miR-503 in breast cancer cell lines reduced cell proliferation through inducing G0/G1 cell cycle arrest by targeting CCND1. Together, our findings provide new knowledge regarding the role of miR-503 in the progression of breast cancer and indicate the role of miR-503 as a tumor suppressor microRNA (miRNA) in breast cancer.
authors.affiliation: Department of Medicinal Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Jianting
authors.initials: J
authors.lastname: Long
authors.affiliation: Key Laboratory of Construction and Detection of Guangdong Province, Southern Medical University, Guangzhou, 510515, People's Republic of China.
authors.forename: Caiwen
authors.initials: C
authors.lastname: Ou
authors.affiliation: Breast Disease Center, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Haoming
authors.initials: H
authors.lastname: Xia
authors.affiliation: Breast Disease Center, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Breast Disease Center, Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, People's Republic of China. dayueliu2015@163.com.
authors.forename: Dayue
authors.initials: D
authors.lastname: Liu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics*; D019938:Cyclin D1 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D059585:G1 Phase Cell Cycle Checkpoints / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D061986:MCF-7 Cells; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C530104:CCND1 protein, human; C545473:MIRN503 microRNA, human; D035683:MicroRNAs; D019938:Cyclin D1
keywords: Breast cancer; CCND1; Cell cycle; Cell proliferation; miR-503