title: Investigation on the genomic diversity of OXA from isolated Acinetobacter baumannii.
abstract: We distinguished the four alleles of OXA subgroups from 138 strains of Acinetobacter baumannii using Polymerase Chain Reaction, and investigated distributions of OXA subgroups in clinical isolated strains. A total of 170 Acinetobacter baumannii were isolated from Shenzhen Longgang Central Hospital between 2010 and 2013. Amplification of OXA genes, blaOXA-23, blaOXA-24, blaOXA-51 and blaOXA-58, were performed by multiplex PCR. Multiplex PCR results showed, out of the 96 strains of Acinetobacter baumannii, 50 (52.08%) strains were positive for only blaOXA51 gene, and 46 (47.92%) showed positive for both blaOXA51 and blaOXA58 genes. Among 96 strains of Acinetobacter baumannii, 48 strains were resistant to carbapenems, and 48 strains were sensitivity to carbapenems. blaOXA51 and blaOXA58 showed resistant or sensitivity to carbapenems. In conclusion, we found that blaOXA-51 and blaOXA-5 were the main mechanisms of resistant or sensitivity to carbapenems.
authors.affiliation: Department of Medical Imaging Center, The First Affiliated Hospital of Jinan University Guangzhou 510632, China ; Department of Respiratory Diseases, Shenzhen Longgang Central Hospital Shenzhen 518116, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, Shenzhen Longgang Central Hospital Shenzhen 518116, China.
authors.forename: Luqiu
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Microbiology laboratory, Shenzhen Longgang Central Hospital Shenzhen 518116, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medical Imaging Center, The First Affiliated Hospital of Jinan University Guangzhou 510632, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Luo
keywords: Acinetobacter baumannii; Genomic diversity; OXA