title: Corticostriatal circuitry and habitual ethanol seeking.
abstract: The development of alcohol-use disorders is thought to involve a transition from casual alcohol use to uncontrolled alcohol-seeking behavior. This review will highlight evidence suggesting that the shift toward inflexible alcohol seeking that occurs across the development of addiction consists, in part, of a progression from goal-directed to habitual behaviors. This shift in "response strategy" is thought to be largely regulated by corticostriatal network activity. Indeed, specific neuroanatomical substrates within the prefrontal cortex and the striatum have been identified as playing opposing roles in the expression of actions and habits. A majority of the research on the neurobiology of habitual behavior has focused on non-drug reward seeking. Here, we will highlight recent research identifying corticostriatal structures that regulate the expression of habitual alcohol seeking and a comparison will be made when possible to findings for non-drug rewards.
authors.affiliation: Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: Barkerj@musc.edu.
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Barker
authors.affiliation: School of Psychology, University of Sydney, Sydney, Australia.
authors.forename: Laura H
authors.initials: LH
authors.lastname: Corbit
authors.affiliation: Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: Donita L
authors.initials: DL
authors.lastname: Robinson
authors.affiliation: Department of Psychology, Neuroscience Graduate Program, University of California San Diego, La Jolla, CA, USA.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Gremel
authors.affiliation: Department of Pharmacology, The University of Texas at Austin, Austin, TX, USA.
authors.forename: Rueben A
authors.initials: RA
authors.lastname: Gonzales
authors.affiliation: Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: L Judson
authors.initials: LJ
authors.lastname: Chandler
mesh_terms: D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D002492:Central Nervous System Depressants; D003216:Conditioning, Operant; D058999:Drug-Seeking Behavior; D000431:Ethanol; D006801:Humans; D017072:Neostriatum / Q000503:physiopathology*; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012201:Reward
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol
keywords: Alcohol; Dorsal striatum; Habit; Nucleus accumbens; Orbitofrontal cortex; Prefrontal cortex