title: Neuromuscular complications of hematopoietic stem cell transplantation.
abstract: Neuromuscular diseases such as polymyositis, dermatomyositis, peripheral neuropathy, and disorders of neuromuscular transmission are reported to be complications of hematopoietic stem cell transplantation (HSCT). Although cases have been reported with allogeneic HSCT in the setting of chronic graft versus host disease, they are also known to occur without evidence thereof and even occur in the setting of autologous HSCT. The 2005 National Institutes of Health Consensus Criteria classify polymyositis and dermatomyositis as "distinctive" features, and neuropathy and MG as "other" features. These neuromuscular complications present very similarly to the idiopathic autoimmune disorders and respond to similar treatment modalities.
authors.affiliation: Medical University of South Carolina, Department of Neurology and Neurosurgery, Neuromuscular Division, 96 Jonathan Lucas Street, CSB 301, Charleston, South Carolina, 29425, USA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Ruzhansky
authors.affiliation: Columbia University Medical Center, Peripheral Neuropathy Center, Neurological Institute, New York, New York, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Brannagan
mesh_terms: D006086:Graft vs Host Disease / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D009468:Neuromuscular Diseases / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*
keywords: allogeneic; autologous stem cell transplant; bone marrow transplant; dermatomyositis; graft versus host disease; myasthenia gravis; neuromuscular complications; peripheral neuropathy; polymyositis