title: Vitamin D and uterine leiomyoma among a sample of US women: Findings from NHANES, 2001-2006.
abstract: Scientific understanding of the etiology of uterine leiomyomata (UL) remains incomplete, but recent investigations have suggested an association between low Vitamin D and UL risk. In this study, we conducted a cross-sectional analysis of Vitamin D exposure, measured using serum levels of 25(OH)D (a Vitamin D metabolite), and self-reported UL diagnosis among 3590 women aged 20-54 in the National Health and Nutrition Examination Survey (NHANES 2001-2006). Multivariate logistic regression models comparing each quartile of 25(OH)D to the lowest quartile indicated no relationship between 25(OH)D and odds of UL in the whole population (Ptrend=0.37), or in sensitivity analyses. However, a probabilistic analysis correcting outcome misclassification indicated that insufficient 25(OH)D was associated with UL in white (Odds ratio (OR) median estimate: 2.17; 2.5, 97.5 percentiles: (1.26, 23.47)), but not black women (OR median estimate: 1.70; 2.5, 97.5 percentiles: (0.89, 3.51)), suggesting misclassification may have driven some of the null findings.
authors.affiliation: Department of Environmental and Occupational Health, Milken Institute School of Public Health at the George Washington University, Washington, DC, United States.
authors.forename: Susanna D
authors.initials: SD
authors.lastname: Mitro
authors.affiliation: Department of Environmental and Occupational Health, Milken Institute School of Public Health at the George Washington University, Washington, DC, United States. Electronic address: azota@gwu.edu.
authors.forename: Ami R
authors.initials: AR
authors.lastname: Zota
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D009749:Nutrition Surveys; D016017:Odds Ratio; D014481:United States; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Fibroid; Misclassification; NHANES; Race; Reproductive health; Uterine leiomyoma; Vitamin D