title: A paradigm shift in platelet transfusion therapy.
abstract: In this issue of Blood, Wang et al report that ex vivo–derived human megakaryocytes infused into mice are trapped in the pulmonary vasculature and release functional platelets into the circulation. Because of the difficulty in scalable generation of ex vivo–derived functional platelets, this strategy may be a substitute for platelet transfusion therapy.
authors.affiliation: UNIVERSITY OF ILLINOIS COLLEGE OF MEDICINE.
authors.forename: Jaehyung
authors.initials: J
authors.lastname: Cho
mesh_terms: D000818:Animals; D001792:Blood Platelets; D006801:Humans; D008264:Macrophages; D008533:Megakaryocytes