title: Age-Disparate Partnerships and Risk of HIV-1 Acquisition Among South African Women Participating in the VOICE Trial.
abstract: A recent analysis from South Africa reported no association between age-disparate relationships and HIV-1 acquisition. We assessed the association between male partner age and HIV-1 acquisition among South African women participating in the VOICE trial. Of 4077 women enrolled, 3789 had complete data; 26% and 5% reported having a partner >5 and >10 years older at enrollment, respectively. Reporting a partner >5 years older (hazard ratio = 1.00; 95% confidence interval: 0.74 to 1.35) or >10 older (hazard ratio = 0.92; 95% confidence interval: 0.49 to 1.74) was not associated with HIV-1 acquisition. These data corroborate recent reports and may suggest a shift in local epidemiology of heterosexual HIV-1 transmission.
authors.affiliation: *Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center; Seattle, WA; †Department of Global Health, University of Washington; Seattle, WA; ‡CAPRISA/University of KwaZulu-Natal, Durban, South Africa; §RTI International, San Francisco, CA; ‖Department of Biostatistics, University of Washington; Seattle, WA; ¶University of Witwatersrand, Johannesburg, South Africa; #South African Medical Research Council, Durban, South Africa; **Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital, Johannesburg, South Africa; ††The Aurum Institute, Klerksdorp, South Africa; ‡‡UZ-UCSF, Harare, Zimbabwe; and §§Department of Medicine, University of Washington, Seattle, WA.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Balkus
authors.forename: Gonasagrie
authors.initials: G
authors.lastname: Nair
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Montgomery
authors.forename: Anu
authors.initials: A
authors.lastname: Mishra
authors.forename: Thesla
authors.initials: T
authors.lastname: Palanee-Phillips
authors.forename: Gita
authors.initials: G
authors.lastname: Ramjee
authors.forename: Ravindre
authors.initials: R
authors.lastname: Panchia
authors.forename: Pearl
authors.initials: P
authors.lastname: Selepe
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: Zvavahera M
authors.initials: ZM
authors.lastname: Chirenje
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: Marrazzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012747:Sexual Partners; D013019:South Africa / Q000453:epidemiology; D055815:Young Adult