title: Effectiveness of 6% hydrogen peroxide concentration for tooth bleaching—A double-blind, randomized clinical trial.
abstract: OBJECTIVE
  The aim of this clinical randomized double-blind split-mouth study was to assess the effectiveness of a 6% hydrogen peroxide with nitrogen-doped titanium dioxide light activated bleaching agent.
  
  
  METHODS
  31 patients were treated with: one upper hemiarcade with a 35% hydrogen peroxide bleaching agent and the other hemiarcade with a 6% hydrogen peroxide. Two applications were completed each treatment session and three sessions were appointed, with one week interval between them. Tooth colour was registered each session and 1 week and 1 months after completing the treatment by spectrophotometer, registering parameters L*, a* and b*, and subjectively using VITA Classic guide. Tooth sensitivity was registered by VAS and patient satisfaction and self-perception result was determined using OHIP-14. Tooth colour variation and sensitivity were compared between both bleaching agents.
  
  
  RESULTS
  Both treatment showed a change between baseline colour and all check-points with a ΔE=5.57 for 6% and of ΔE=7.98 for the 35% one month after completing the (p<0.05). No statistical differences were seen when subjective evaluations were compared. Also, no differences were seen in tooth sensitivity between bleaching agents. OHIP-14 questionnaire demonstrated a significant change for all patients after bleaching.
  
  
  CONCLUSIONS
  A 6% hydrogen peroxide with nitrogen-doped titanium dioxide light activated agent is effective for tooth bleaching, reaching a ΔE of 5.57 one month after completing the treatment, with no clinical differences to a 35% agent neither in colour change or in tooth sensitivity.
  
  
  CONCLUSIONS
  A low concentration hydrogen peroxide bleaching agent may reach good clinical results with less adverse effects.
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Chile, Sergio Livingstone Pohlhammer 943, Independencia, Santiago, Chile; Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Martín
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Chile, Sergio Livingstone Pohlhammer 943, Independencia, Santiago, Chile; Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Vildósola
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Chile, Sergio Livingstone Pohlhammer 943, Independencia, Santiago, Chile; Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Bersezio
authors.affiliation: Department of Basic Sciences, Faculty of Dentistry, University of Chile, Sergio Livingstone Pohlhammer 943, Independencia, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Herrera
authors.affiliation: Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Bortolatto
authors.affiliation: Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: J R C
authors.initials: JR
authors.lastname: Saad
authors.affiliation: Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil.
authors.forename: O B
authors.initials: OB
authors.lastname: Oliveira
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Chile, Sergio Livingstone Pohlhammer 943, Independencia, Santiago, Chile; Univ. Estadual Paulista-Unesp, School of Dentistry, Rua Humaitá, 1680-Centro-CEP, 14801-903 Araraquara, Brazil. Electronic address: edofdez@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: Fernández
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D017060:Patient Satisfaction; D013053:Spectrophotometry; D014025:Titanium / Q000008:administration & dosage / Q000009:adverse effects; D014073:Tooth Bleaching / Q000009:adverse effects / Q000379:methods*; D058205:Tooth Bleaching Agents / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D058205:Tooth Bleaching Agents; C009495:titanium dioxide; D006861:Hydrogen Peroxide; D014025:Titanium
keywords: Bleaching teeth; Clinical randomized trial; Effectiveness; Low concentration; OHIP-14; Titanium dioxide