title: Influence of age on IgE response in peanut-allergic children and adolescents from the Mediterranean area.
abstract: BACKGROUND
  Peanut allergens are common triggers of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms, and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9, and Pru p 3 in a peanut allergic children/adolescents and the relationship with peach and pollen.
  
  
  METHODS
  Peanut allergic patients aged between 1 and 20 years old were classified into two groups: A) allergic to peanut only and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9, and Pru p 3.
  
  
  RESULTS
  Of 964 subjects evaluated, 28% were allergic to peanut. From this group, 68% were also sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty-eight percent had Ara h 2- and/or Ara h 9-specific IgE. More than half reported symptoms with peanut alone (Group A) and 35% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms, and sensitization to Artemisia between groups. IgE response to Ara h 2 was more frequent in Group A, and Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age.
  
  
  CONCLUSIONS
  Peanut allergy is frequent in subjects with allergy to plant foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients, Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.
authors.affiliation: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Garcia-Blanca
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Aranda
authors.affiliation: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Blanca-Lopez
authors.affiliation: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Perez
authors.affiliation: Allergy UGC, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Gomez
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Mayorga
authors.affiliation: Allergy UGC, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres
authors.affiliation: Plant Biotechnology Institute (UPM-INIA), Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Diaz-Perales
authors.affiliation: Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Perkins
authors.affiliation: Biochemistry and Molecular Biology Department, University Complutense Madrid, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Villalba
authors.affiliation: Allergy UGC, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Blanca
authors.affiliation: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Canto
mesh_terms: D055516:2S Albumins, Plant / Q000276:immunology*; D000293:Adolescent; D000367:Age Factors; D000707:Anaphylaxis / Q000175:diagnosis / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007223:Infant; D007428:Intradermal Tests; D008297:Male; D021183:Peanut Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D010940:Plant Proteins / Q000276:immunology*; D011237:Predictive Value of Tests; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000276:immunology; D012698:Serologic Tests; D013030:Spain; D013997:Time Factors; D014581:Urticaria / Q000175:diagnosis / Q000276:immunology; D055815:Young Adult
chemical_list: D055516:2S Albumins, Plant; D052179:Antigens, Plant; C500890:Ara h 2 allergen, Arachis hypogaea; C544631:Ara h 9 allergen, peanut; D015415:Biomarkers; D006023:Glycoproteins; D010940:Plant Proteins; C463181:Pru p 3 allergen; D007073:Immunoglobulin E
keywords: allergens; food allergy; lipid transfer proteins; peach; peanut; seed storage proteins; sensitization