title: Leptin keeps working, even in obesity.
abstract: The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling. In this issue, Ottaway et al. (2015) use leptin antagonists to reveal persistence (or even elevation) of endogenous leptin signaling and physiologic action in diet-induced obesity.
authors.affiliation: Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: mgmyers@umich.edu.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Myers
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects*; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*
chemical_list: D020738:Leptin