title: BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds.
abstract: Phenolic compounds are secondary metabolites involved in several plant growth and development processes, including resistance to biotic and abiotic stresses. The biosynthetic pathways leading to the vast diversity of plant phenolic products often include an acylation step, with phenolic compounds being the donor or acceptor molecules. To date, two acyltransferase families using phenolic compounds as acceptor or donor molecules have been described, with each using a different 'energy-rich' acyl donor. BAHD-acyltransferases, named after the first four biochemically characterized enzymes of the group, use acyl-CoA thioesters as donor molecules, whereas SCPL (Serine CarboxyPeptidase Like)-acyltransferases use 1-O-β-glucose esters. Here, common and divergent specifications found in the literature for both enzyme families were analyzed to answer the following questions. Are both acyltransferases involved in the synthesis of the same molecule (or same group of molecules)? Are both acyltransferases recruited in the same plant? How does the subcellular localization of these enzymes impact metabolite trafficking in plant cells?
authors.affiliation: INRA, UMR1083 SPO, 2, place, Viala, F-34060, Montpellier, France.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Bontpart
authors.affiliation: INRA, UMR1083 SPO, 2, place, Viala, F-34060, Montpellier, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Cheynier
authors.affiliation: INRA, UMR1083 SPO, 2, place, Viala, F-34060, Montpellier, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Ageorges
authors.affiliation: INRA, UMR1083 SPO, 2, place, Viala, F-34060, Montpellier, France.
authors.forename: Nancy
authors.initials: N
authors.lastname: Terrier
mesh_terms: D000215:Acylation; D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D010636:Phenols / Q000378:metabolism*; D010944:Plants / Q000201:enzymology* / Q000235:genetics; D064210:Secondary Metabolism
chemical_list: D010636:Phenols; D000217:Acyltransferases
keywords: BAHD; Serine CarboxyPeptidase-Like (SCPL); acylation; acyltransferase; biosynthesis; phenolic compounds; secondary metabolite