title: Epidemiological Aspects of Hepatitis B and C Markers in Blood Donors in Kazakhstan; 2000-2011.
abstract: BACKGROUND
  Transfusion-transmissible infections such as hepatitis B and hepatitis C are among the greatest threats to blood safety for transfusion recipients and pose a serious public health problem. The aim of this study was to assess the epidemiological aspects of hepatitis B and C in Kazakhstani donor's blood over the period 2000-2011.
  
  
  METHODS
  The data were obtained from the annual reports of the Republican Blood Center. The retrospective study was conducted from 2000 to 2011.
  
  
  RESULTS
  Over the study period in the republic a growth of volumes of procured blood from 312.4 to 398.0 units was noted, in total equaled to 4,277.8 units. The proportion of blood wasted increased from 8.3% to 8.7%. In the dynamics the proportion of viral hepatitis among all causes of blood wasted decreased from 29% to 15.5% (HBV) and from 33.5% to 9.9% (HCV). The proportion of HBV and HCV in whole blood decreased considerably, in plasma and red cell concentrate the rates changed slightly. The average annual prevalence of HBV and HCV were 2.1% and 1.8%, respectively.
  
  
  CONCLUSIONS
  Despite the reduction of viral hepatitis rates among blood donors in Kazakhstan the prevalence still remains high. The HBV prevalence is higher compared to HCV, which needs further investigations in the general population to address the issue.
authors.affiliation: 1. Research Institute of Traumatology and Orthopedics, Astana , Kazakhstan ; 2. PA "Central Asian Cancer Institute", Astana , Kazakhstan.
authors.forename: Nurbek
authors.initials: N
authors.lastname: Igissinov
authors.affiliation: 2. PA "Central Asian Cancer Institute", Astana , Kazakhstan ; 3. JSC "Astana Medical University", Astana , Kazakhstan.
authors.forename: Dariyana
authors.initials: D
authors.lastname: Kulmirzayeva
authors.affiliation: 4. Faculty of Medical Sciences, University of Groningen , Netherlands.
authors.forename: Cees Th Smit
authors.initials: CT
authors.lastname: Sibinga
authors.affiliation: 3. JSC "Astana Medical University", Astana , Kazakhstan.
authors.forename: Asiya
authors.initials: A
authors.lastname: Turgambayeva
keywords: Blood donors; Hepatitis B virus; Hepatitis C virus; Kazakhstan