title: A comparative study of corneal endothelial structure between diabetes and non-diabetes.
abstract: BACKGROUND
  The corneal endothelial structure may be changed in diabetic patients, but the results were variable.
  
  
  OBJECTIVE
  To compare the corneal endothelial structure including endothelial cell density, polymorphism, andpleomorphism, in diabetic and non-diabetic subjects.
  
  
  METHODS
  The corneal endothelial structure of diabetic and non-diabetic subjects were measured by specular microscope (Confoscan4 (CS4), Nidek) for endothelial cell density, percentage of polymegathism, and percentage of hexagonal cells. The data were analyzed using the descriptive statistics and the unpaired t-test.
  
  
  RESULTS
  There were 171 eyes of 90 diabetic patients with the mean age of 58.49 ± 9.78 years, and 156 eyes of 90 non-diabetic subjects with the mean age of 58.98 ± 13.12 years. Three parameters of measurement revealed no significant difference (p > 0.05). The over one year diabetic patients, however demonstrated a decreased percentage of hexagonal cells statistically significant (p < 0.05), while the over two years diabetic patients demonstrated a decreased percentage of hexagonal cell and an increased percentage of polymegathism statistically signifcant (p < 0.05).
  
  
  CONCLUSIONS
  The corneal endothelial structure is not different between diabetic and non-diabetic groups. When the disease progresses, however the hexagonal cells decrease at first, followed by the polymegathism. No difference shows in endothelial cell density.
authors.forename: Wichai
authors.initials: W
authors.lastname: Leelawongtawun
authors.forename: Wannisa
authors.initials: W
authors.lastname: Suphachearaphan
authors.forename: Kosol
authors.initials: K
authors.lastname: Kampitak
authors.forename: Ratree
authors.initials: R
authors.lastname: Leelawongtawun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002452:Cell Count; D003920:Diabetes Mellitus / Q000473:pathology*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged