title: Pitfalls in reporting sample size calculation in randomized controlled trials published in leading anaesthesia journals: a systematic review.
abstract: We have evaluated the pitfalls in reporting sample size calculation in randomized controlled trials (RCTs) published in the 10 highest impact factor anaesthesia journals.Superiority RCTs published in 2013 were identified and checked for the basic components required for sample size calculation and replication. The difference between the reported and replicated sample size was estimated. The sources used for estimating the expected effect size (Δ) were identified, and the difference between the expected and observed effect sizes (Δ gap) was estimated.We enrolled 194 RCTs. Sample size calculation was reported in 91.7% of studies. Replication of sample size calculation was possible in 80.3% of studies. The original and replicated sample sizes were identical in 67.8% of studies. The difference between the replicated and reported sample sizes exceeded 10% in 28.7% of studies. The expected and observed effect sizes were comparable in RCTs with positive outcomes (P=0.1). Studies with negative outcome tended to overestimate the effect size (Δ gap 42%, 95% confidence interval 32-51%), P<0.001. Post hoc power of negative studies was 20.2% (95% confidence interval 13.4-27.1%). Studies using data derived from pilot studies for sample size calculation were associated with the smallest Δ gaps (P=0.008).Sample size calculation is frequently reported in anaesthesia journals, but the details of basic elements for calculation are not consistently provided. In almost one-third of RCTs, the reported and replicated sample sizes were not identical and the assumptions for the expected effect size and variance were not supported by relevant literature or pilot studies.
authors.affiliation: Anaesthetic Department, Faculty of Medicine, Cairo University, Giza, Egypt mohamedabdulatif53@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Abdulatif
authors.affiliation: Anaesthetic Department, Faculty of Medicine, Cairo University, Giza, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: Mukhtar
authors.affiliation: Anaesthetic Department, Faculty of Medicine, Cairo University, Giza, Egypt.
authors.forename: G
authors.initials: G
authors.lastname: Obayah
mesh_terms: D000776:Anesthesiology / Q000592:standards*; D006801:Humans; D010506:Periodicals as Topic / Q000592:standards*; D011643:Publishing / Q000592:standards; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D012107:Research Design; D018401:Sample Size
keywords: research hypothesis, effect size; statistical power, sample size; study design, superiority trials