title: A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage.
abstract: A new cationic gadolinium contrast agent is reported for delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). The agent partitions into the glycosaminoglycan rich matrix of articular cartilage, based on Donnan equilibrium theory, and its use enables imaging of the human cadaveric metacarpal phalangeal joint.
authors.affiliation: Department of Pharmacology at Boston University and Boston University School of Medicine, Boston, MA.|Center for Advanced Orthopaedic Studies Harvard Medical School, Boston, MA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Freedman
authors.affiliation: Department of Chemistry Boston University School of Medicine, Boston, MA.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Lusic
authors.affiliation: Center for Advanced Orthopaedic Studies Harvard Medical School, Boston, MA.
authors.forename: Martin
authors.initials: M
authors.lastname: Wiewiorski
authors.affiliation: MRI Core Facility, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA.|MIT Institute for Medical Engineering & Science, Cambridge, MA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Farley
authors.affiliation: Center for Advanced Orthopaedic Studies Harvard Medical School, Boston, MA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Snyder
authors.affiliation: Department of Chemistry Boston University School of Medicine, Boston, MA.|Department of Biomedical Engineering Boston University School of Medicine, Boston, MA.|Department of Pharmacology at Boston University and Boston University School of Medicine, Boston, MA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology*; D002412:Cations / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008662:Metacarpophalangeal Joint / Q000473:pathology*
chemical_list: D002412:Cations; D003287:Contrast Media; D005682:Gadolinium