title: Effectiveness of azelastine nasal spray in the treatment of adenoidal hyper-trophy in children.
abstract: OBJECTIVE
  To evaluate the effects of topical azelastine treatment on symptoms related to adenoid hypertrophy and the size of adenoid tissue in children.
  
  
  METHODS
  In total, 60 children who were found to have adenoid hypertrophy were included. A questionnaire on nasal symptoms, nasal endoscopy and skin prick tests was administered to all patients. All patients had complaints of chronic nasal obstruction symptoms and nasal endoscopy showed > 75% choanal obstruction, attributable to adenoid pads. The adenoid/nasopharyngeal areas were calculated. All of the patients underwent azelastine nasal spray therapy (1 spray per nostril, twice daily; 0.28 mg/dose) for 30 days. After 1 month, all children were reassessed. The efficacy of therapy, symptoms, adenoid / nasopharynx ratio, and obstruction ratio, obtained by endoscopy, were compared.
  
  
  RESULTS
  Azelastine treatment was well tolerated by all patients. After the first treatment period, the severity of symptoms, endoscopic grade, and adenoid size decreased in all of the 60 patients. There were significant improvements in total subjective symptoms (nasal obstruction, rhinorrhea, cough, snoring, and obstructive sleep apnea) post-treatment.
  
  
  CONCLUSIONS
  Azelastine nasal spray may be useful in decreasing adenoid pad size and the severity of symptoms related to adenoidal hypertrophy. Hippokratia 2014; 18 (4): 340-345.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Berkiten
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: T L
authors.initials: TL
authors.lastname: Kumral
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Çakır
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Yıldırım
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Salturk
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Uyar
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Atar
keywords: Azelastine; adenoid; pediatrics; topical administration