title: Response of Relapsed Pancreatoblastoma to a Combination of Vinorelbine and Oral Cyclophosphamide.
abstract: Pancreatoblastoma is a rare tumor of the pancreas in children, with favorable prognosis if completely resected. If unresectable, neoadjuvant chemotherapy with cisplatin-based regimens are commonly used with good response that allows for resection. For locally aggressive or metastatic disease, neoadjuvant chemotherapy has been reported. Treatment for relapsed or refractory cases is based on anecdotal experiences. We report 2 cases of relapsing pancreatoblastoma with clinical and radiologic response to vinorelbine and cyclophosphamide. Although cure was not achieved, this combination can be offered as an easily tolerated alternative to aggressive chemotherapy for relapsed cases in a palliative setting.
authors.affiliation: *Khoo Teck Puat-National University Children's Medical Institute, National University Health System †Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore ‡The University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Chetan
authors.initials: C
authors.lastname: Dhamne
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Herzog
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000556:secondary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D003520:Cyclophosphamide; D000077235:Vinorelbine