title: CD-163 correlated with symptoms (pain or discomfort) of prostatic inflammation.
abstract: The purpose of this study is to identify significant immune-system related for symptom of patients with prostatic inflammation in order to investigate the etiology of prostatic inflammation which may relate to potentially chronic prostatitis (CP). We investigated the expression of immune system-related biomarkers such as Interleukin (IL) -6 (humoral immunity), CD-3 (T-lymphocyte), and CD-163 (macrophage) in prostate biopsy (PBx) specimens from patients with prostatic inflammation (without cancer) which had been neither clinically diagnosed benign prostatic hyperplasia nor chronic prostatitis. We examined the correlation between these markers' expressions and the symptom scores using the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS)/quality of life (QOL) which are the index for lower urinary tract symptoms (LUTS). Our results showed CD-163 (macrophage) reflected pain or discomfort on NIH-CPSI scores (P=0.0389 and r=0.3307) in the patients with prostatic inflammation; however, the control patients had no significant correlation between symptom scores and those immune-related markers' expression. These results suggest that pain or discomfort related to macrophages in the relationship between immune-system and the symptom of prostatic inflammation. In conclusion, CD-163, related to immune-system (macrophage), correlated with symptoms (pain or discomfort) of prostatic inflammation and might represent a significant immune-system related biomarker for pain or LUTS score in potentially CP.
authors.affiliation: Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine Kobe, Japan.
authors.forename: Fukashi
authors.initials: F
authors.lastname: Yamamichi
authors.affiliation: Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine Kobe, Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shigemura
authors.affiliation: Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine Kobe, Japan.
authors.forename: Soichi
authors.initials: S
authors.lastname: Arakawa
authors.affiliation: Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine Kobe, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: Department of Surgery, Division of Urology, Kobe University Graduate School of Medicine Kobe, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D017252:CD3 Complex / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D010147:Pain Measurement; D011237:Predictive Value of Tests; D011467:Prostate / Q000276:immunology*; D011472:Prostatitis / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000523:psychology; D011788:Quality of Life; D011956:Receptors, Cell Surface / Q000032:analysis*; D011795:Surveys and Questionnaires; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015415:Biomarkers; D000098902:CD163 Antigen; D017252:CD3 Complex; C508600:IL6 protein, human; D015850:Interleukin-6; D011956:Receptors, Cell Surface
keywords: CD-163; CD-3; IL-6; prostatic inflammation; symptom scores