title: Impact of cholesterol on disease progression.
abstract: Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.
authors.affiliation: Department of Urology, University of Texas Southwestern Medical Center, Texas, Dallas, 75235, USA.
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Lin
authors.forename: Cheng-Kuo
authors.initials: CK
authors.lastname: Lai
authors.forename: Min-Chuan
authors.initials: MC
authors.lastname: Kao
authors.forename: Lii-Tzu
authors.initials: LT
authors.lastname: Wu
authors.forename: U-Ging
authors.initials: UG
authors.lastname: Lo
authors.forename: Li-Chiung
authors.initials: LC
authors.lastname: Lin
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Chen
authors.forename: Ho
authors.initials: H
authors.lastname: Lin
authors.forename: Jer-Tsong
authors.initials: JT
authors.lastname: Hsieh
authors.forename: Chih-Ho
authors.initials: CH
authors.lastname: Lai
authors.forename: Chia-Der
authors.initials: CD
authors.lastname: Lin