title: Growth hormone insensitivity: diagnostic and therapeutic approaches.
abstract: BACKGROUND
  Growth hormone resistance defines several genetic (primary) and acquired (secondary) pathologies that result in completely or partially interrupted activity of growth hormone. An archetypal disease of this group is the Laron-type dwarfism caused by mutations in growth hormone receptors. The diagnosis is based on high basal levels of growth hormone, low insulin like growth factor-I (IGF-1) level, unresponsiveness to IGF generation test and genetic testing. Recombinant IGF-1 preparations are used in the treatment
  
  
  CONCLUSIONS
  In this article, clinical characteristics, diagnosis and therapeutic approaches of the genetic and other diseases leading to growth hormone insensitivity are reviewed.
authors.affiliation: Department of Pediatric Endocrinology, Medical Faculty, Erciyes University, 38039, Kayseri, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Kurtoğlu
authors.affiliation: Department of Pediatric Endocrinology, Medical Faculty, Erciyes University, 38039, Kayseri, Turkey. nihalhatipoglu@yahoo.com.
authors.forename: N
authors.initials: N
authors.lastname: Hatipoglu
mesh_terms: D004351:Drug Resistance / Q000235:genetics; D006130:Growth Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D046150:Laron Syndrome / Q000175:diagnosis* / Q000628:therapy*; D011986:Receptors, Somatotropin / Q000235:genetics
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
keywords: Growth hormone; IGF-1 generation test; Insensitivity; Recombinant IGF-1