title: [Treating irritable bowel syndrome by wuling capsule combined pinaverium bromide: a clinical research].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of wuling Capsule combined with Pinaverium Bromide in treatment of irritable bowel syndrome (IBS).
  
  
  METHODS
  Sixty-four IBS patients were randomized into two groups, the treatment group and the control group, 32 in each group. Patients in the treatment group took wuling Capsule (0. 33 g/capsule, 3 times per day) and Pinaverium Bromide (50 mg/tablet, one tablet each time, 3 times per day) , while those in the control group only took Pinaverium Bromide (50 mg/tablet, one tablet each time, 3 times per day). The therapeutic course for all was 6 weeks. IBS symptom score questionnaire, IBS-Quality of Life (IBS-QOL) , Self-Rating Depression Scale (SDS) , and Self-Rating Anxiety Scale (SAS) were assessed before and after treatment. Adverse reactions were also observed.
  
  
  RESULTS
  The improvement of abdominal pain, stool frequency, and stool properties, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). The improvement of dysphoria, body image, concerns for health, and dietary restriction of IBS-QOL, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). The improvement of SDS and SAS, as well as changing rates of integrals were significantly higher in the treatment group than in the control group (P <0. 05). No severe adverse reaction occurred in either group.
  
  
  CONCLUSIONS
  Combination therapy of wuling Capsule and Pinaverium Bromide could improve abdominal pain and defecation, attenuate depression and anxiety of IBS patients with higher safety.
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Hou
authors.forename: Hong-zan
authors.initials: HZ
authors.lastname: Ji
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Liang
authors.forename: Lian-e
authors.initials: LE
authors.lastname: Xu
authors.forename: Fang-yu
authors.initials: FY
authors.lastname: Wang
mesh_terms: D001007:Anxiety; D001008:Anxiety Disorders; D035843:Biomedical Research; D002214:Capsules; D003672:Defecation; D003863:Depression; D003866:Depressive Disorder; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D009025:Morpholines / Q000627:therapeutic use*; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D009025:Morpholines; C533472:wuling; C013199:pinaverium