title: Peroxide-based oxygen generating topical wound dressing for enhancing healing of dermal wounds.
abstract: Oxygen generating biomaterials represent a new trend in regenerative medicine that aims to generate and supply oxygen at the site of requirement, to support tissue healing and regeneration. To enhance the healing of dermal wounds, we have developed a highly portable, in situ oxygen generating wound dressings that uses sodium percarbonate (SPO) and calcium peroxide (CPO) as chemical oxygen sources. The dressing continuously generated oxygen for more than 3 days, after which it was replaced. In the in vivo testing on porcine full-thickness porcine wound model, the SPO/CPO dressing showed enhanced wound healing during the 8 week study period. Quantitative measurements of wound healing related parameters, such as wound closure, reepithelialization, epidermal thickness and collagen content of dermis showed that supplying oxygen topically using the SPO/CPO dressing significantly accelerated the wound healing. An increase in neovascularization, as determined using Von Willebrand factor (vWF) and CD31 staining, was also observed in the presence of SPO/CPO dressing. This novel design for a wound dressing that contains oxygen generating biomaterials (SPO/CPO) for supplying topical oxygen, may find utility in treating various types of acute to chronic wounds.
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Prafulla K
authors.initials: PK
authors.lastname: Chandra
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Ross
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Leona C
authors.initials: LC
authors.lastname: Smith
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Seon S
authors.initials: SS
authors.lastname: Jeong
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Jaehyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: James J
authors.initials: JJ
authors.lastname: Yoo
authors.affiliation: Wake Forest School of Medicine Institute for Regenerative Medicine, Winston Salem, North Carolina.
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Harrison
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D018919:Neovascularization, Physiologic; D010100:Oxygen / Q000494:pharmacology*; D010545:Peroxides / Q000494:pharmacology*; D012038:Regeneration; D044968:Regenerative Medicine; D017695:Soft Tissue Injuries / Q000473:pathology*; D013552:Swine; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D010545:Peroxides; C403632:calcium peroxide; D010100:Oxygen
keywords: Collagen; Peroxide; Skin; Topical oxygen therapy; Wound closure; Wound healing