title: Relationship Between BMD and Prevalent Vertebral Fractures in Indian Women Older Than 50 Yr.
abstract: The purpose of the study was to study the relationship of morphometric vertebral fractures with bone mineral density (BMD) in Indian women older than 50 yr. Four hundred fifteen healthy Indian women older than 50 yr (mean age: 62.8 yr) underwent lateral X-rays of the lumbar and thoracic spine. Genant's semiquantitative method was used to diagnose and classify morphometric vertebral fractures. BMD was measured by DXA at lumbar spine and total hip. Recruited subjects underwent anthropometric, biochemical, and hormonal evaluation. Vertebral fractures were present in 17.1% (95% confidence interval: 13.5, 20.8) subjects. Prevalence of osteoporosis based on BMD was 35.7%. By adding those with prevalent fractures, the number of women requiring therapy for osteoporosis would increase to 46.5%. The BMD measured at femur neck, total hip, and lumbar spine (L1eL4) was not found to be lower in women with vertebral fractures as compared with those without fractures. BMD was not found to be lower in women with vertebral fractures as compared with those without fractures. Significant number of additional subjects with BMD in the normal or osteopenic range become eligible for osteoporosis treatment when presence of vertebral fracture is used as an independent indication for such treatment.
authors.affiliation: Department of Medicine, Government Medical College and Hospital, Chandigarh 160030, India.
authors.forename: Yashdeep
authors.initials: Y
authors.lastname: Gupta
authors.affiliation: ILSI, New Delhi 110024, India.
authors.forename: Raman K
authors.initials: RK
authors.lastname: Marwaha
authors.affiliation: Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Illinois, Chicago, USA.
authors.forename: Subhash
authors.initials: S
authors.lastname: Kukreja
authors.affiliation: Department of Endocrinology and Thyroid Research Centre, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India.
authors.forename: Kuntal
authors.initials: K
authors.lastname: Bhadra
authors.affiliation: Department of Medicine, Dr B.R.Sur Homoeopathic Medical College Hospital& Research Centre, Moti Bagh, New Delhi 110021, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Narang
authors.affiliation: Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Kalaivani
authors.initials: K
authors.lastname: Mani
authors.affiliation: Department of Endocrinology and Diabetes, Medanta Medicity, Gurgaon, Delhi NCR, India.
authors.forename: Ambrish
authors.initials: A
authors.lastname: Mithal
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: nikhil_tandon@hotmail.com.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Tandon
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015519:Bone Density; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries / Q000378:metabolism; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D012307:Risk Factors; D016103:Spinal Fractures / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D013223:Statistics as Topic; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries / Q000378:metabolism
chemical_list: D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Asian; Genant's semi-quantitative method; Indian; bone mineral density; vertebral fractures