title: The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex.
abstract: In recent years, multiple studies have shown task-induced negative blood-oxygenation-level-dependent responses (NBRs) in multiple brain regions in humans and animals. Converging evidence suggests that task-induced NBRs can be interpreted in terms of decreased neuronal activity. However, the vascular and metabolic dynamics and functional importance of the NBR are highly debated. Here, we review studies investigating the origin and functional importance of the NBR, with special attention to the somatosensory cortex.
authors.forename: Carsten M
authors.initials: CM
authors.lastname: Klingner
authors.forename: Stefan
authors.initials: S
authors.lastname: Brodoehl
authors.forename: Otto W
authors.initials: OW
authors.lastname: Witte
mesh_terms: D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000502:physiology*
chemical_list: D010100:Oxygen