title: Notes from the Field: Outbreaks of Shigella sonnei Infection with Decreased Susceptibility to Azithromycin Among Men Who Have Sex with Men - Chicago and Metropolitan Minneapolis-St. Paul, 2014.
abstract: Increasing rates of shigellosis among adult males, particularly men who have sex with men (MSM), have been documented in the United States, Canada, and Europe, and MSM appear to be at greater risk for infection with shigellae that are not susceptible to ciprofloxacin or azithromycin. Azithromycin is the first-line empiric antimicrobial treatment for shigellosis among children and is a second-line treatment among adults. Isolates collected in 2014 in two U.S. cities from outbreaks of shigellosis displayed highly similar pulsed-field gel electrophoresis (PFGE) patterns and decreased susceptibility to azithromycin (DSA). This report summarizes and compares the findings from investigations of the two outbreaks, which occurred among MSM in metropolitan Minneapolis-St. Paul, Minnesota, and Chicago, Illinois.
authors.forename: Anna
authors.initials: A
authors.lastname: Bowen
authors.forename: Dana
authors.initials: D
authors.lastname: Eikmeier
authors.forename: Pamela
authors.initials: P
authors.lastname: Talley
authors.forename: Alicia
authors.initials: A
authors.lastname: Siston
authors.forename: Shamika
authors.initials: S
authors.lastname: Smith
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Hurd
authors.forename: Kirk
authors.initials: K
authors.lastname: Smith
authors.forename: Fe
authors.initials: F
authors.lastname: Leano
authors.forename: Amelia
authors.initials: A
authors.lastname: Bicknese
authors.forename: J Corbin
authors.initials: JC
authors.lastname: Norton
authors.forename: Davina
authors.initials: D
authors.lastname: Campbell
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D002641:Chicago / Q000453:epidemiology; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D016521:Electrophoresis, Gel, Pulsed-Field; D018451:Homosexuality, Male / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012764:Shigella sonnei / Q000187:drug effects* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin