title: Isolated double pituitary adenomas: A silent corticotroph adenoma and a microprolactinoma.
abstract: We report a 27-year-old woman with amenorrhea and galactorrhea with mildly elevated serum prolactin levels. Her MRI demonstrated a cystic macroadenoma in the left aspect of the sella and a small microadenoma in the right aspect of the sella. Endoscopic transsphenoidal resection of the tumors revealed two histologically distinct tumors. The left tumor was consistent with a silent corticotroph macroadenoma and the right tumor was a prolactin producing microadenoma. Isolated double pituitary adenomas that are clearly separated by normal pituitary gland tissue are extremely rare. The incidence is approximately 0.37-2.6%. The coexistence of double adenomas can pose diagnostic and management challenges for the pituitary neuroendocrine team.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Shira
authors.initials: S
authors.lastname: Eytan
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Ki-Yoon
authors.initials: KY
authors.lastname: Kim
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: David
authors.initials: D
authors.lastname: Bleich
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Maya
authors.initials: M
authors.lastname: Raghuwanshi
authors.affiliation: Department of Neurological Surgery, Rutgers New Jersey Medical School, Suite 8100, 90 Bergen Street, Newark, NJ 07103, USA; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA.
authors.forename: Jean Anderson
authors.initials: JA
authors.lastname: Eloy
authors.affiliation: Department of Neurological Surgery, Rutgers New Jersey Medical School, Suite 8100, 90 Bergen Street, Newark, NJ 07103, USA; Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA; Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, USA. Electronic address: james.liu.md@rutgers.edu.
authors.forename: James K
authors.initials: JK
authors.lastname: Liu
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000236:Adenoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011247:Pregnancy; D015175:Prolactinoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery
keywords: Bilateral; Double pituitary adenomas; Macroadenoma; Microadenoma; Prolactinoma; Transsphenoidal surgery