title: Effects of a Novel Dental Gel on Plaque and Gingivitis: A Comparative Study.
abstract: OBJECTIVE
  The goal of this prospective, randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on plaque and gingival health. The dental gel was designed to (1) break up and prevent re-accumulation of microbial biofilm, and (2) inhibit metal mediated inflammation.
  
  
  METHODS
  Twenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥2) and pocket depths <4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. On Days 0, 7, 14 and 21, plaque levels (Quigley-Hein, Turesky Modification Plaque Index), gingival inflammation (Löe and Silness Gingival Index) and gingival bleeding (modified Sulcus Bleeding Index) were determined by one blinded, investigator using a pressure sensitive probe.
  
  
  RESULTS
  After 3 weeks, all 3 clinical indices were significantly improved in both groups (P<0.05) and significantly lower in the test group (P<0.05).
  
  
  CONCLUSIONS
  The novel dental gel formulation was provided effective plaque control and reduced gingival inflammation.
  
  
  CONCLUSIONS
  A novel dentifrice formulation may be an effective tool for plaque removal and maintaining gingival health.
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA.
authors.forename: M
authors.initials: M
authors.lastname: Dadkhah
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Chung
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ajdaharian
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA ; School of Dental Hygiene, Concorde Career College, Garden Grove, California 92840, USA.
authors.forename: C
authors.initials: C
authors.lastname: Wink
authors.affiliation: School of Dentistry, Section of Periodontics, University of California, Los Angeles, California 90095, USA.
authors.forename: P
authors.initials: P
authors.lastname: Klokkevold
authors.affiliation: Beckman Laser Institute, University of California, Irvine, California 92612, USA.
authors.forename: P
authors.initials: P
authors.lastname: Wilder-Smith
keywords: Biofilm; Dentifrice; Gingival inflammation; Oral hygiene; Plaque