title: From Glomerular Endothelium to Podocyte Pathobiology in Preeclampsia: a Paradigm Shift.
abstract: Preeclampsia is a pregnancy-specific syndrome characterized by renal dysfunction and high blood pressure. When evaluated with light microscopy, the renal lesion of preeclampsia is marked by endothelial cell swelling and the appearance of bloodless glomeruli. However, regarding the pathobiology of renal damage in preeclampsia, attention recently has shifted from the glomerular endothelial cells to the podocytes. The angiogenic imbalance in preeclampsia plays a key role in the development of both podocyte and endothelial damage in the glomerular filtration barrier. Here, we review the latest studies on the role of podocytes in the development of renal damage in preeclampsia and on podocytes as potential targets for diagnosis, treatment, and prevention of long-term complications of preeclampsia.
authors.affiliation: Department of Pathology, L1 Q, Leiden University Medical Centre, PO Box 9600, P0-107, 2300 RC, Leiden, The Netherlands.
authors.forename: Rosanne J
authors.initials: RJ
authors.lastname: Turner
authors.forename: Kitty W M
authors.initials: KW
authors.lastname: Bloemenkamp
authors.forename: Marlies E
authors.initials: ME
authors.lastname: Penning
authors.forename: Jan Anthonie
authors.initials: JA
authors.lastname: Bruijn
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Baelde
mesh_terms: D000818:Animals; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D050199:Podocytes / Q000473:pathology*; D011225:Pre-Eclampsia / Q000378:metabolism / Q000503:physiopathology*; D057285:Precision Medicine; D011247:Pregnancy; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A