title: [IgG4-related disease: a possible cause of obstructive jaundice].
abstract: Immunoglobulin G4 related disease (IgG4-RD) has been recognized since early 2000s as an entity comprising a set of inflammatory diseases with common histopathological features. The disease may affect almost all organs and tissues, and often occurs in a subacute fashion in males over 50 years as a mass or diffuse enlargement of affected organs. The histopathological appearance is characterized by a lymphoplasmacytic infiltration with predominantly IgG4-positive plasma cells and progressive fibrosis. Its clinical and radiological features can make the distinction with a malignancy difficult. The disease responds well to systemic glucocorticoids however with a high rate of recurrence after treatment discontinuation.
authors.forename: M
authors.initials: M
authors.lastname: Moreillon
authors.forename: P
authors.initials: P
authors.lastname: Yan
authors.forename: G
authors.initials: G
authors.lastname: Buss
authors.forename: P-A
authors.initials: PA
authors.lastname: Bart
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D005938:Glucocorticoids; D007074:Immunoglobulin G