title: Suicide in Recent Onset Psychosis Revisited: Significant Reduction of Suicide Rate over the Last Two Decades - A Replication Study of a Dutch Incidence Cohort.
abstract: This study aims to compare the suicide risk over the past decade following recent onset psychosis to findings from the eighties and nineties in the same catchment area and to identify predictors of suicide in the context of the Psychosis Recent Onset Groningen-Survey (PROGR-S). A medical file search was carried out to determine the current status of all patients admitted between 2000 and 2009. The suicide rate was compared with a study executed in 1973-1988 in the same catchment area. Predictors of suicide were investigated using Cox regression. The status of 424 of the 614 patients was known in July 2014. Suicide occurred in 2.4% of patients with psychosis disorders (n = 10; mean follow-up 5.6 years); 6 out of 10 suicides took place within two years. Within two decades, the suicide rate dropped from 11% (follow-up 15 years, 8.5% after 5 years) to 2.4%. The Standardized Mortality Rate (SMR) of suicides compared with the general population was 41.6. A higher age was the only significant predictor for suicide. Neuroticism, living situation, disorganized and negative symptoms, and passive coping style all showed a trend for significance. A significant reduction in the suicide rate was found for people with psychosis over the past decades. Given the high SMR, suicide research should be given the highest priority. Identifying predictors may contribute to further reduction of suicide among patients with psychosis.
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Lentis Research, Lentis Psychiatric Institute, Groningen, The Netherlands.
authors.forename: Stynke
authors.initials: S
authors.lastname: Castelein
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; NeuroImaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Edith J
authors.initials: EJ
authors.lastname: Liemburg
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Jill S
authors.initials: JS
authors.lastname: de Lange
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; University Center for Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Frank D
authors.initials: FD
authors.lastname: van Es
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Ellen
authors.initials: E
authors.lastname: Visser
authors.affiliation: NeuroImaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Psychology, University of Groningen, Groningen, The Netherlands.
authors.forename: André
authors.initials: A
authors.lastname: Aleman
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; University Center for Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Richard
authors.initials: R
authors.lastname: Bruggeman
authors.affiliation: Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Lentis Research, Lentis Psychiatric Institute, Groningen, The Netherlands; NeuroImaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Henderikus
authors.initials: H
authors.lastname: Knegtering
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009426:Netherlands; D011618:Psychotic Disorders / Q000453:epidemiology*; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*