title: Novel Strategies for the Diagnosis of Posttraumatic Infections in Orthopaedic Trauma Patients.
abstract: Orthopaedic infections that occur after trauma are common. Clinical examination, laboratory markers, imaging modalities, and culture and molecular technologies are used to aid the diagnosis of infection. Culture methods comprise the backbone of diagnostic systems used in hospital laboratory settings; however, several studies have questioned the ability of these techniques to adequately identify infections, particularly in cases where orthopaedic implants were used or when the presence of biofilm bacteria is suspected. Advances in imaging and molecular diagnostics can provide orthopaedic surgeons with an improved means of diagnosing and treating infections.
authors.forename: Reza
authors.initials: R
authors.lastname: Firoozabadi
authors.forename: Timothy
authors.initials: T
authors.lastname: Alton
authors.forename: Joseph
authors.initials: J
authors.lastname: Wenke
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D018441:Biofilms / Q000254:growth & development; D019317:Evidence-Based Medicine; D050723:Fractures, Bone / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008826:Microbial Sensitivity Tests; D009141:Musculoskeletal System / Q000293:injuries*; D009984:Orthopedic Fixation Devices / Q000009:adverse effects; D019736:Prostheses and Implants / Q000009:adverse effects; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*; D012307:Risk Factors; D014947:Wounds and Injuries / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents
keywords: infection; molecular diagnostics; posttraumatic