title: New oral anticoagulants: their role in stroke prevention in high-risk patients with atrial fibrillation.
abstract: Based on efficacy, safety, and ease of use, novel oral anticoagulants will likely replace VKAs for many if not most patients with atrial fibrillation. Novel anticoagulants have a lower rate of intracranial hemorrhage compared with vitamin K antagonists. The incidence of other life-threatening bleeds is similar if not lower. Dose adjustments need to be made based on renal function and advanced age. There is at present a need for an antidote for these new drugs.
authors.affiliation: Department of Pediatrics, University of North Carolina, College of Medicine, 101 Manning Drive, Chapel Hill, NC 27599, USA.
authors.forename: Sunita J
authors.initials: SJ
authors.lastname: Ferns
authors.affiliation: Penn State Hershey heart and Vascular Institute, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA. Electronic address: gnaccarelli@hmc.psu.edu.
authors.forename: Gerald V
authors.initials: GV
authors.lastname: Naccarelli
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications* / Q000628:therapy; D004334:Drug Administration Schedule; D004347:Drug Interactions; D016903:Drug Monitoring; D065427:Factor Xa Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control*; D013997:Time Factors; D054556:Venous Thromboembolism / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors
keywords: Anticoagulation; Atrial fibrillation; Factor IIa inhibitors; Factor Xa inhibitors; Novel oral anticoagulants; Stroke