title: Animal models of glucocorticoid-induced glaucoma.
abstract: Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.
authors.affiliation: Department of Bioengineering, Imperial College London, London, UK.
authors.forename: Darryl R
authors.initials: DR
authors.lastname: Overby
authors.affiliation: North Texas Eye Research Institute, U. North Texas Health Science Center, Ft. Worth, TX, USA. Electronic address: abe.clark@unthsc.edu.
authors.forename: Abbot F
authors.initials: AF
authors.lastname: Clark
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005901:Glaucoma / Q000139:chemically induced* / Q000503:physiopathology; D005938:Glucocorticoids / Q000633:toxicity*; D007429:Intraocular Pressure / Q000187:drug effects*
chemical_list: D005938:Glucocorticoids
keywords: Glaucoma; Glucocorticoid; Intraocular pressure; Ocular hypertension; Steroid glaucoma