title: Interactions of HIV-1 proteins as targets for developing anti-HIV-1 peptides.
abstract: Protein-protein interactions (PPI) are essential in every step of the HIV replication cycle. Mapping the interactions between viral and host proteins is a fundamental target for the design and development of new therapeutics. In this review, we focus on rational development of anti-HIV-1 peptides based on mapping viral-host and viral-viral protein interactions all across the HIV-1 replication cycle. We also discuss the mechanism of action, specificity and stability of these peptides, which are designed to inhibit PPI. Some of these peptides are excellent tools to study the mechanisms of PPI in HIV-1 replication cycle and for the development of anti-HIV-1 drug leads that modulate PPI.
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel.|Department of Chemistry, Midnapore College, West Bengal, India.
authors.forename: Koushik
authors.initials: K
authors.lastname: Chandra
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Maes
authors.affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel.
authors.forename: Assaf
authors.initials: A
authors.lastname: Friedler
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054298:Human Immunodeficiency Virus Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D054298:Human Immunodeficiency Virus Proteins; D010455:Peptides