title: Ghrelin in Critical Illness.
abstract: Ghrelin, a recently described peptide, has attracted significant attention in recent years, primarily in the context of its endocrine- and appetite-regulating effects. The versatility of this peptide is manifested in a rapidly expanding body of literature highlighting its nonendocrine functions. This review summarizes the available data on the immunomodulatory as well as the non-immune-mediated effects of ghrelin that form the scientific basis of its role in critical illness.
authors.affiliation: 1 Pulmonary Diseases Critical Care Medicine, Respiratory Institute, Cleveland Clinic Foundation, Cleveland, Ohio.|2 Respiratory Critical Care & Sleep Medicine Associates, Baptist Medical Center, Jacksonville, Florida; and.
authors.forename: Tathagat
authors.identifier: http://orcid.org/0000-0003-4631-9888
authors.initials: T
authors.lastname: Narula
authors.affiliation: 3 Section of Pulmonary/Critical Care Medicine, Department of Medicine, LSU Health Sciences Center, New Orleans, Louisiana.
authors.forename: Bennett P
authors.initials: BP
authors.lastname: deBoisblanc
mesh_terms: D000818:Animals; D001066:Appetite; D002319:Cardiovascular System / Q000503:physiopathology; D016638:Critical Illness; D004727:Endothelium / Q000503:physiopathology; D054439:Ghrelin / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D056747:Immunomodulation; D007249:Inflammation
chemical_list: D054439:Ghrelin
keywords: cytokines; ghrelin; immunity; leptin; sepsis