title: Translational Bioinformatics and Clinical Research (Biomedical) Informatics.
abstract: Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations.
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address: sirintrs@mskcc.org.
authors.forename: S Joseph
authors.initials: SJ
authors.lastname: Sirintrapun
authors.affiliation: Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Zehir
authors.affiliation: Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
authors.forename: Aijazuddin
authors.initials: A
authors.lastname: Syed
authors.affiliation: Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
authors.forename: JianJiong
authors.initials: J
authors.lastname: Gao
authors.affiliation: Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Schultz
authors.affiliation: Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
authors.forename: Donavan T
authors.initials: DT
authors.lastname: Cheng
mesh_terms: D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D023281:Genomics / Q000379:methods; D006801:Humans; D008490:Medical Informatics / Q000379:methods*; D009369:Neoplasms / Q000235:genetics; D057170:Translational Research, Biomedical / Q000379:methods*
keywords: Bioinformatics; Biomedical informatics; Cancer genomics; Clinical research informatics; TCGA; The Cancer Genome Atlas; Translational informatics; cBioPortal