title: [Comprehensive evaluation of drug interaction screening programs: discrepancies and concordances].
abstract: BACKGROUND
  Recognition of potentially harmful drug interactions is one of the duties of healthcare. However, solutions involving databases are fraught with contradictions due to the lack of standardized principles and data.
  
  
  OBJECTIVE
  The aims of the authors were to perform a comparative evaluation of Hungarian and international databases and to explore ambiguities and contradictions in order to develop more standardized criteria for screening interactions.
  
  
  METHODS
  Four Hungarian and two English-language websites and software, and the summaries of product characteristics were compared. The authors analyzed 40 drug-drug and 8 drug-supplement interactions and looked at 8 cases, which represent 28 pairs of interacting substances.
  
  
  RESULTS
  The databases warn about most interactions, but these warnings were rarely helpful in preventing undesired consequences. The authors found discrepancies between the databases in 70% of interactions. When looking at different products with the same active ingredients, discrepancies cropped up in 0-66.7% of the cases. Up to 80% of searches for supplementary product interactions did not produce satisfactory results.
  
  
  CONCLUSIONS
  In the present situation mapping these ambiguities and creating a standardized classification system would be advantageous.
authors.affiliation: Gyógyszerészeti Intézet és Klinikai Központi Gyógyszertár, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Honvéd u. 3., 7624.
authors.forename: Anna
authors.initials: A
authors.lastname: Somogyi-Végh
authors.forename: Bernadett
authors.initials: B
authors.lastname: Nyaka
authors.forename: Róbert György
authors.initials: RG
authors.lastname: Vida
authors.forename: Andrea
authors.initials: A
authors.lastname: Lovász
authors.forename: Lajos
authors.initials: L
authors.lastname: Botz
mesh_terms: D016208:Databases, Factual / Q000592:standards / Q000706:statistics & numerical data; D019587:Dietary Supplements; D004347:Drug Interactions; D006801:Humans; D006814:Hungary; D007391:International Cooperation; D008403:Mass Screening / Q000592:standards / Q000639:trends
keywords: drug information; drug interactions; drug–supplement interaction; gyógyszer-információ; gyógyszer-interakció; gyógyszerkölcsönhatás; interaction database; interaction screening; interakciós adatbázis; kölcsönhatásszűrés; megelőzés