title: Outcome of B-Cell Acute Lymphoblastic Leukemia in Brazilian Children: Immunophenotypical, Hematological, and Clinical Evaluation.
abstract: The aim of this study is to investigate the clinical, hematological, and immunophenotypic characteristics of Brazilian children with B-cell acute lymphoblastic leukemia (B-ALL) to identify prognostic biomarkers of the disease. Thirty-three children newly diagnosed with B-ALL were followed between March 2004 and December 2009. Information about the demographic profile, diagnosis, immunophenotype, clinical manifestations, and disease outcome were gathered from the patients' medical records. Of the 33 patients with B-ALL, 18 were male and 15 female. Eighteen patients were classified as high risk; 13 as low risk, and 2 as true low risk. The frequencies of cluster of differentiation (CD)10, CD19, and CD20 antigens were 69.7%, 81.8%, and 18.2%, respectively. Six patients (18.2%) had aberrant expression of myeloid antigens. At diagnosis, patients immunopositive for CD20 had elevated white blood cell counts (P = 0.018) and lower platelet counts (P = 0.017). The 6-year overall survival was 67.5%± 3.47%. Our results demonstrate the distinct immunophenotypic and prognostic characteristics of patients with B-ALL, which can be related to the Brazilian racial admixture. Consequently, these results will most likely aid in the selection of additional prognostic markers and their use in monitoring the clinical manifestations and treatment response among B-ALL patients.
authors.affiliation: *Centro de Pesquisas Gonçalo Moniz (CPqGM), Fundação Oswaldo Cruz (FIOCRUZ) †Department of Ciências da vida (DCV), Universidade do estado da Bahia (UNEB) ‡Faculdade de Farmácia (FAC-FAR), Universidade Federal da Bahia (UFBA) §Faculdade de Farmácia (FAC-FAR), Universidade Federal do Amazonas (UFAM) ∥Hospital São Rafael/ONCO ¶Instituto Nacional de Ciência e Tecnologia do Sangue (INCT do sangue), Bahia, Brazil.
authors.forename: Rodrigo S
authors.initials: RS
authors.lastname: Cézar
authors.forename: Bruno A V
authors.initials: BA
authors.lastname: Cerqueira
authors.forename: Silvana de Souza
authors.initials: Sde S
authors.lastname: da Paz
authors.forename: Cynara G
authors.initials: CG
authors.lastname: Barbosa
authors.forename: José P
authors.initials: JP
authors.lastname: de Moura Neto
authors.forename: José H de S
authors.initials: JH
authors.lastname: Barreto
authors.forename: Marilda de S
authors.initials: Mde S
authors.lastname: Goncalves
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis*; D019070:Cell Lineage; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011379:Prognosis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor