title: The prognostic significance of a postoperative systemic inflammatory response in patients with colorectal cancer.
abstract: BACKGROUND
  Recently, a preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). However, the prognostic significance of a systemic inflammatory response in the early stage after surgery in patients with CRC is unknown. The aim of this retrospective study was to evaluate the prognostic significance of a postoperative systemic inflammatory response in patients with CRC.
  
  
  METHODS
  Two hundred and fifty-four patients who underwent potentially curative surgery for stage II/III CRC were enrolled in this study. Univariate and multivariate analyses were performed to evaluate the relationship between the prognosis and clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS), which were measured within two weeks before operation and at the first visit after leaving the hospital.
  
  
  RESULTS
  The overall survival rates were significantly worse in the high preoperative NLR/preoperative GPS/postoperative NLR group. A multivariate analysis indicated that only preoperative GPS, postoperative NLR, and the number of lymph node metastases were independent prognostic factors for a poor survival.
  
  
  CONCLUSIONS
  The postoperative NLR is an independent prognostic factor in patients with CRC who underwent potentially curative surgery.
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. fbxbj429@ybb.ne.jp.
authors.forename: Masatsune
authors.initials: M
authors.lastname: Shibutani
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. tora@med.osaka-cu.ac.jp.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. hisashi@med.osaka-cu.ac.jp.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nagahara
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. m5051923@msic.med.osaka-cu.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. yatchan_0622.ej20@me.com.
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Iseki
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. tetsu_47@msn.com.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ikeya
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. suganononono@yahoo.co.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugano
authors.affiliation: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-Ku Osaka City Osaka Prefecture, 545-8585, Abeno-ku, Osaka, Japan. hirakawa@med.osaka-cu.ac.jp.
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology; D007958:Leukocyte Count; D008207:Lymphatic Metastasis; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate
chemical_list: D015415:Biomarkers