title: Darier disease: A fold (intertriginous) dermatosis.
abstract: Darier disease, also known as Darier-White disease, is characterized by yellow to brown, oily keratotic papules and plaques in the seborrheic areas of the face and chest. This disorder may show different clinical manifestations, such as palmoplantar pits and nail abnormalities. The trigger factors are mechanical trauma, heat, humidity, ultraviolet B, and pyogenic infections. The disease usually becomes apparent in the second decade of life. The ATP2 A2 (SERCA2) gene mutation was detected in all patients. Histopathologic changes include epidermal adhesion loss, acantholysis, abnormal keratinization, eosinophilic dyskeratotic cells in the spinous layer known as corps ronds, and the presence of grains in the stratum corneum. Although the treatment for Darier disease is unsatisfactory, some relief has been achieved with the use of corticosteroids and retinoids.
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey. Electronic address: burhanengin2000@yahoo.com.
authors.forename: Burhan
authors.initials: B
authors.lastname: Engin
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Zekayi
authors.initials: Z
authors.lastname: Kutlubay
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Erkan
authors.affiliation: Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University, Fatih, Istanbul 34098, Turkey.
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Tüzün
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D007644:Darier Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007402:Intertrigo / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D009154:Mutation; D011379:Prognosis; D012176:Retinoids / Q000627:therapeutic use; D018570:Risk Assessment; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D012176:Retinoids; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human