title: Effect of expressions of tumor necrosis factor α and interleukin 1B on peritoneal metastasis of gastric cancer.
abstract: Our study aimed to investigate effect of expressions of tumor necrosis factor α (TNF-α) and interleukin 1B (IL-1B) on peritoneal metastasis of gastric cancer (GC). From June 2012 to June 2014, a total of 60 patients with advanced peritoneal metastasis from GC were collected from Department of Gastrointestinal and Nutriology Surgery at Shengjing Hospital of China Medical University. Furthermore, 60 GC patients without peritoneal metastasis were enrolled as controls. Immunohistochemistry was performed to test TNF-α and IL-1B expression, and logistic regression analysis was employed for evaluating risk factors for peritoneal metastasis of GC. Our results showed that TNF-α expression in metastatic group and non-metastatic group was significantly different (P = 0.043), but no significant difference was found in IL-1B expression between two groups (P = 0.261). In addition, TNF-α expression in metastatic group and non-metastatic group was associated with tumor size, depth of invasion, the degree of differentiation (all P < 0.05). Logistic regression analysis indicated that tumor size, depth of invasion, the degree of differentiation and TNF-α expression were risk factors for peritoneal metastasis of GC (all P < 0.05). Our study found that TNF-α expression may play a vital role in peritoneal metastasis of GC, while IL-1B expression might not be correlated with peritoneal metastasis.
authors.affiliation: Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China. guolin698@126.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.
authors.forename: Jin-Lei
authors.initials: JL
authors.lastname: Ou
authors.affiliation: Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Gastrointestinal and Nutriology Surgery, Shengjing Hospital of China Medical University, Sanhao Street No.36, Heping District, Shenyang, 110004, People's Republic of China.
authors.forename: Long-Fei
authors.initials: LF
authors.lastname: Qu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010534:Peritoneal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha
keywords: Gastric cancer; Immunohistochemistry; Interleukin 1B; Peritoneal metastasis; Tumor necrosis factor α; Tumor size