title: Complementary Use of LC-ICP-MS and LC-ESI-Q-TOF-MS for Selenium Speciation.
abstract: We demonstrated the complementary use of inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) for the analysis of Se-containing compounds, such as selenate, selenomethionine (SeMet), and trimethylselenonium ion (TMSe), found in biological samples. The sensitivity of ESI-Q-TOF-MS for Se-containing compounds was strongly dependent on the chemical species. ICP-MS exhibited higher sensitivity than ESI-Q-TOF-MS, and had no species dependency. On the other hand, ESI-Q-TOF-MS enabled easy and robust identification of Se-containing compounds.
authors.affiliation: Laboratory of Chemical Toxicology and Environmental Health, Showa Pharmaceutical University.
authors.forename: Yasumi
authors.initials: Y
authors.lastname: Anan
authors.forename: Genki
authors.initials: G
authors.lastname: Nakajima
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Ogra
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D057230:Limit of Detection; D012643:Selenium / Q000032:analysis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D012643:Selenium