title: Effect of S100A6 over-expression on β-catenin in endometriosis.
abstract: OBJECTIVE
  S100A6 is over-expressed in several human tumors, including pancreatic carcinoma, malignant fibrous histiocytoma, breast, colon, and gastric carcinoma, but little is known about the role of S100A6 in endometriosis. The aim of the present study was to investigate the effect of S100A6 over-expression on β-catenin in endometrial stromal cells.
  
  
  METHODS
  Endometrial stromal cells were transfected with an hS100A6-expressing recombinant lentivirus construct. The expression of β-catenin was assessed using western blot and reverse transcription-polymerase chain reaction.
  
  
  RESULTS
  S100A6 over-expression promoted β-catenin expression at the RNA and protein levels, in endometrial stromal cells.
  
  
  CONCLUSIONS
  S100A6 induces expression of β-catenin in endometrial stromal cells.
authors.affiliation: Medical Department of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Zequn
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
authors.forename: Meihong
authors.initials: M
authors.lastname: Chen
authors.affiliation: Key Laboratory of Molecular Medicine of Jiangxi Province, Nanchang, Jiangxi, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Cao
authors.affiliation: Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Huang
mesh_terms: D000328:Adult; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D004715:Endometriosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D010049:Ovarian Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D014162:Transfection; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; D051176:beta Catenin; C055351:S100A6 protein, human
keywords: endometrial stromal cell; over-expressed S100A6; β-catenin