title: Peptide aptamers: Novel coatings for orthopaedic implants.
abstract: Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite-peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
authors.forename: Micah
authors.initials: M
authors.lastname: Kelly
authors.affiliation: School of Chemical Engineering, University of Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Williams
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
authors.forename: Anuriti
authors.initials: A
authors.lastname: Aojula
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: Jenna
authors.initials: J
authors.lastname: O'Neill
authors.affiliation: School of Metallurgy and Materials, University of Birmingham, United Kingdom.
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Trzińscka
authors.affiliation: School of Chemical Engineering, University of Birmingham, United Kingdom.
authors.forename: Liam
authors.initials: L
authors.lastname: Grover
authors.affiliation: Royal Centre for Defence Medicine, Queen Elizabeth Hospital, Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: Robert A H
authors.initials: RA
authors.lastname: Scott
authors.affiliation: School of Chemistry, University of Birmingham, United Kingdom.
authors.forename: Anna F A
authors.initials: AF
authors.lastname: Peacock
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors.forename: Ann
authors.initials: A
authors.lastname: Logan
authors.affiliation: School of Metallurgy and Materials, University of Birmingham, United Kingdom.
authors.forename: Artemis
authors.initials: A
authors.lastname: Stamboulis
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom; NIHR SRMRC Trauma Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom. Electronic address: f.decogan@bham.ac.uk.
authors.forename: Felicity
authors.initials: F
authors.lastname: de Cogan
mesh_terms: D052158:Aptamers, Peptide / Q000737:chemistry*; D032701:Biomimetics; D045744:Cell Line, Tumor; D002516:Ceramics / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009985:Orthopedics / Q000379:methods*; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D052158:Aptamers, Peptide; D020099:Coated Materials, Biocompatible; D003094:Collagen; D017886:Durapatite; D014025:Titanium
keywords: Biomimetic peptide; Hydroxyapatite coating; Implant coating; Peptide coating; Titanium coating