title: Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides.
abstract: Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups.
authors.affiliation: Department of Chemistry and Biochemistry, the University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS 39406, USA. emily.vogel@eagles.usm.edu.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Vogel
authors.affiliation: Department of Chemistry and Biochemistry, the University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS 39406, USA. william.r.jackson@eagles.usm.edu.
authors.forename: William
authors.initials: W
authors.lastname: Jackson
authors.affiliation: Department of Chemistry and Biochemistry, the University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS 39406, USA. douglas.masterson@usm.edu.
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Masterson
mesh_terms: D004951:Esterification; D019803:Glutathione Disulfide / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D010455:Peptides; D019803:Glutathione Disulfide
keywords: amino acids; carboxylic acids; esterification; esters; peptide esterification