title: Aggregation-Induced Emission Active Metal-Free Chemosensing Platform for Highly Selective Turn-On Sensing and Bioimaging of Pyrophosphate Anion.
abstract: We report the synthesis of a metal-free chemosensor for highly selective sensing of pyrophosphate (PPi) anion in physiological medium. The novel phenylbenzimidazole functionalized imine containing chemosensor (L; [2,6-bis(((4-(1H-benzo[d]imidazol-2-yl)phenyl)imino) methyl)-4 methyl phenol]) could sense PPi anion through "turn-on" colorimetric and fluorimetric responses in a very competitive environment. The overall sensing mechanism is based on the aggregation-induced emission (AIE) phenomenon. Moreover, a real time in-field device application was demonstrated by sensing PPi in paper strips coated with L. Interestingly, detection of intracellular PPi ions in model human cells could also be possible by fluorescence microscopic studies without any toxicity to these cells.
authors.affiliation: †Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Gogoi
authors.affiliation: ‡Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
authors.forename: Sandipan
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: ‡Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
authors.forename: Aiyagari
authors.initials: A
authors.lastname: Ramesh
authors.affiliation: †Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.
authors.forename: Gopal
authors.initials: G
authors.lastname: Das
mesh_terms: D000838:Anions; D011756:Diphosphates / Q000032:analysis*; D006367:HeLa Cells; D006801:Humans; D008670:Metals / Q000737:chemistry*; D018625:Microscopy, Atomic Force
chemical_list: D000838:Anions; D011756:Diphosphates; D008670:Metals