title: Tex10: A New Player in the Core Pluripotency Circuitry.
abstract: Revealing how the core pluripotency circuitry is orchestrated to maintain the ground state of embryonic stem cells (ESCs) is fundamental for understanding self-renewal and early lineage specifications. In this issue of Cell Stem Cell, Ding et al. (2015) identify a new Sox2-interacting protein, Tex10, which, together with Tet1 and p300, regulate super-enhancers to sustain pluripotency.
authors.affiliation: Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel. Electronic address: yossibug@ekmd.huji.ac.il.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Buganim
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000378:metabolism*
chemical_list: D009687:Nuclear Proteins