title: [Drug-induced pancreatitis. A review of French spontaneous reports].
abstract: OBJECTIVE
  Identify the main pharmacological classes inducing pancreatitis using spontaneous reports recorded in the French pharmacovigilance database (FPVD).
  
  
  METHODS
  Cases of pancreatitis recorded in FPVD between January 1st 1985 and December 31st 2013 were selected using the 2001 consensus conference criteria of the French High Health Authority.
  
  
  RESULTS
  During this period, 2975 observations were selected with 1151 fulfilling criteria of drug-induced pancreatitis (i.e. 0.22% of total notifications in the FPVD). According to ATC classification, the pharmacological classes most frequently found were antiretroviral, analgesic, lipid-lowering, immunosuppressive and insulin secreting drugs. For some drugs (metformin, omeprazole, etc.) pancreatitis was "unlabelled" in the summary of product characteristics.
  
  
  CONCLUSIONS
  This review allows to identify the main drug classes currently involved in spontaneous reporting of pancreatitis in France.
authors.affiliation: Laboratoire de pharmacologie médicale et clinique, centre de Midi-Pyrénées de pharmacovigilance, de pharmaco-épidémiologie et d'informations sur le médicament, équipe de pharmaco-épidémiologie de l'UMR, Inserm U1027, CHU de Toulouse, faculté de médecine, université de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: L
authors.initials: L
authors.lastname: Chebane
authors.affiliation: Laboratoire de pharmacologie médicale et clinique, centre de Midi-Pyrénées de pharmacovigilance, de pharmaco-épidémiologie et d'informations sur le médicament, équipe de pharmaco-épidémiologie de l'UMR, Inserm U1027, CHU de Toulouse, faculté de médecine, université de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France. Electronic address: haleh.bagheri@univ-tlse3.fr.
authors.forename: H
authors.initials: H
authors.lastname: Bagheri
authors.affiliation: Centre régional de pharmacovigilance de Montpellier, 34295 Montpellier cedex 5, France.
authors.forename: D
authors.initials: D
authors.lastname: Hillaire-Buys
authors.affiliation: Centre régional de pharmacovigilance de Bordeaux, 33076 Bordeaux cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Géniaux
authors.affiliation: Centre régional de pharmacovigilance de Grenoble, 38043 Grenoble cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Yahioui
authors.affiliation: Centre régional de pharmacovigilance de Limoges, 87042 Limoges cedex, France.
authors.forename: M-L
authors.initials: ML
authors.lastname: Laroche
authors.affiliation: Centre régional de pharmacovigilance de Lyon, 69424 Lyon cedex 3, France.
authors.forename: J
authors.initials: J
authors.lastname: Cottin
authors.affiliation: Centre régional de pharmacovigilance de Nice, 06003 Nice cedex 1, France.
authors.forename: A
authors.initials: A
authors.lastname: Spreux
authors.affiliation: Centre régional de pharmacovigilance de Caen, 14033 Caen cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Mosquet
authors.affiliation: Centre de pharmacovigilance de Paris Cochin, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Pecriaux
authors.affiliation: Centre régional de pharmacovigilance de St-Étienne, 42055 Saint-Étienne cedex 02, France.
authors.forename: F
authors.initials: F
authors.lastname: Bellet
authors.affiliation: Centre régional de pharmacovigilance de Strasbourg, 67091 Strasbourg cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lambert
authors.affiliation: Laboratoire de pharmacologie médicale et clinique, centre de Midi-Pyrénées de pharmacovigilance, de pharmaco-épidémiologie et d'informations sur le médicament, équipe de pharmaco-épidémiologie de l'UMR, Inserm U1027, CHU de Toulouse, faculté de médecine, université de Toulouse, 37, allées Jules-Guesde, 31000 Toulouse, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000592:standards / Q000706:statistics & numerical data; D016208:Databases, Factual / Q000592:standards / Q000706:statistics & numerical data; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000453:epidemiology*; D005602:France / Q000453:epidemiology; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced*; D004364:Pharmaceutical Preparations / Q000145:classification*; D060735:Pharmacovigilance
chemical_list: D004364:Pharmaceutical Preparations
keywords: Adverse drug reactions; Drug-induced pancreatitis; Effets indésirables; Pancréatite médicamenteuse; Pharmacovigilance