title: Daily Physical Activity Assessed by a Triaxial Accelerometer Is Beneficially Associated with Waist Circumference, Serum Triglycerides, and Insulin Resistance in Japanese Patients with Prediabetes or Untreated Early Type 2 Diabetes.
abstract: OBJECTIVE
  To investigate the association between daily physical activity and metabolic risk factors in Japanese adults with prediabetes or untreated early type 2 diabetes (T2D).
  
  
  METHODS
  Daily physical activity level was measured using a triaxial accelerometer. We assessed correlations between physical activity level and waist circumference, blood pressure, fasting levels of plasma glucose, serum triglycerides, and insulin and homeostasis model assessment-insulin resistance (HOMA-IR).
  
  
  RESULTS
  A total of 80 patients were studied. After adjustment for age and body mass index, in all subjects, physical activity level was negatively associated with waist circumference (β = -0.124, P = 0.018) and fasting serum triglycerides (β = -0.239, P = 0.035), insulin (β = -0.224, P = 0.022). In men, physical activity level was negatively associated with systolic blood pressure (β = -0.351, P = 0.044), fasting plasma glucose (β = -0.369, P = 0.025) and insulin (β = -0.362, P = 0.012), and HOMA-IR (β = -0.371, P = 0.011). No significant associations were found between physical activity level and metabolic risk factors in women.
  
  
  CONCLUSIONS
  Objectively measured daily physical activity is beneficially associated with waist circumference, serum triglycerides, and insulin resistance in individuals with prediabetes or untreated early T2D. (This trial is registered with UMIN000015774.).
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan ; General Internal Medicine, Community Healthcare Studies, Jichi Medical University Graduate School, Tochigi 329-0498, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hamasaki
authors.affiliation: Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Noda
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Sumie
authors.initials: S
authors.lastname: Moriyama
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Reo
authors.initials: R
authors.lastname: Yoshikawa
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Katsuyama
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Akahito
authors.initials: A
authors.lastname: Sako
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Mishima
authors.affiliation: General Internal Medicine, Community Healthcare Studies, Jichi Medical University Graduate School, Tochigi 329-0498, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kakei
authors.affiliation: Department of Human Health and Design, Faculty of Human Life and Environmental Sciences, Showa Women's University, Tokyo 154-8533, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ezaki
authors.affiliation: Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba 272-8516, Japan.
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Yanai
mesh_terms: D061725:Accelerometry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D007564:Japan; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D011236:Prediabetic State / Q000097:blood / Q000503:physiopathology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference / Q000502:physiology*
chemical_list: D007328:Insulin; D014280:Triglycerides