title: Ethanol-related alterations in gene expression patterns in the developing murine hippocampus.
abstract: It is well known that consuming alcohol prior to and during pregnancy can cause harm to the developing fetus. Fetal alcohol spectrum disorder is a term commonly used to describe a range of disabilities that may arise from prenatal alcohol exposure such as fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorders, and alcohol-related birth defects. Here, we report that maternal binge alcohol consumption alters several important genes that are involved in nervous system development in the mouse hippocampus at embryonic day 18. Microarray analysis revealed that Nova1, Ntng1, Gal, Neurog2, Neurod2, and Fezf2 gene expressions are altered in the fetal hippocampus. Pathway analysis also revealed the association of the calcium signaling pathway in addition to other pathways with the differentially expressed genes during early brain development. Alteration of such important genes and dynamics of the signaling pathways may cause neurodevelopmental disorders. Our findings offer insight into the molecular mechanism involved in neurodevelopmental disorders associated with alcohol-related defects.
authors.affiliation: Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea.
authors.forename: Chanchal
authors.initials: C
authors.lastname: Mandal
authors.affiliation: Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea.
authors.forename: Kyoung Sun
authors.initials: KS
authors.lastname: Park
authors.affiliation: Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea Institute of Natural Science and Technology, Hanyang University, Ansan, Republic of Korea ygchai@hanyang.ac.kr khjung2@gmail.com.
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jung
authors.affiliation: Department of Molecular and Life Science, Hanyang University, Ansan, Republic of Korea Department of Nanobiotechnology, Hanyang University, Seoul, Republic of Korea ygchai@hanyang.ac.kr khjung2@gmail.com.
authors.forename: Young Gyu
authors.initials: YG
authors.lastname: Chai
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects* / Q000196:embryology / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D011247:Pregnancy; D059467:Transcriptome / Q000187:drug effects
chemical_list: D009419:Nerve Tissue Proteins; D000431:Ethanol
keywords: alcohol consumption; calcium signaling pathway; microarray analysis; nervous system development