title: Influence of ceria nanoparticles on chemical structure and properties of segmented polyesters.
abstract: In this work, we present new nanocomposite materials derived from segmented copolyesters, comprising ethylene terephthalate (PET) segments and dimerized linoleic acid (DLA), and nanometric cerium oxide particles (CeO2). Nanoparticles were incorporated in situ during polycondensation in various concentrations, from 0.1 up to 0.6 wt.%. It was found that preparation of nanocomposites in situ, during polycondensation, had no significant influence on changes in segmental composition as determined from (1)H and (13)C, as well as 2D NMR. Thermal analysis and calculated degree of crystallinity showed that increasing concentration of ceria nanoparticles lead to an increase in mass content of PET crystallites in hard segments. The XRD investigations also showed an increased intensity of characteristic signals with increasing ceria concentration. Simultaneously, the incorporation of CeO2 led to an increase in tensile strength and elongation at break, indicating a reinforcing and plasticizing effect of ceria nanoparticles. However, the modulus at 10% strain decreased with increasing amount of nanoparticles. The in vitro culture of human cardiac progenitor cells (hCPCs) on the new materials indicated a homogenous cell displacement across the samples after 5 days with no signs of cytotoxicity, indicating good biocompatibility in vitro of CeO2-based nanocomposites and a potential for biomedical applications.
authors.affiliation: West Pomeranian University of Technology, Szczecin, Polymer Institute, Division of Biomaterials and Microbiological Technologies, Al. Piastów 45, 70-311 Szczecin, Poland. Electronic address: mirfray@zut.edu.pl.
authors.forename: M
authors.initials: M
authors.lastname: El Fray
authors.affiliation: West Pomeranian University of Technology, Szczecin, Polymer Institute, Division of Biomaterials and Microbiological Technologies, Al. Piastów 45, 70-311 Szczecin, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Strzalkowska
authors.affiliation: International Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Mandoli
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Department of Internal Medicine, University of Rome "Tor Vergata", Rome 00133, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pagliari
authors.affiliation: Laboratory of Molecular and Cellular Cardiology, Department of Internal Medicine, University of Rome "Tor Vergata", Rome 00133, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Di Nardo
authors.affiliation: International Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Traversa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D048430:Cell Shape / Q000187:drug effects; D002478:Cells, Cultured; D002563:Cerium / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008875:Middle Aged; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D002563:Cerium; C030583:ceric oxide
keywords: Biocompatibility; Nanocomposites; PET–DLA copolyesters; Phase structure