title: Metal based drugs: design, synthesis and in-vitro antimicrobial screening of Co(II), Ni(II), Cu(II) and Zn(II) complexes with some new carboxamide derived compounds: crystal structures of N-[ethyl(propan-2-yl)carbamothioyl]thiophene-2-carboxamide and its copper(II) complex.
abstract: A new series of compounds derived from thiophene-2-carboxamide were synthesized and characterized by IR, (1)H-NMR and (13)C-NMR, mass spectrometry and elemental analysis. These compounds were further used to prepare their Co(II), Ni(II), Cu(II) and Zn(II) metal complexes. All metal(II) complexes were air and moisture stable. Physical, spectral and analytical data have shown the Ni(II) and Cu(II) complexes to exhibit distorted square-planar and Co(II) and Zn(II) complexes tetrahedral geometries. The ligand (L(1)) and its Cu(II) complex were characterized by the single-crystal X-ray diffraction method. All the ligands and their metal(II) complexes were screened for their in-vitro antimicrobial activity. The antibacterial and antifungal bioactivity data showed that the metal(II) complexes were found to be more potent than the parent ligands against one or more bacterial and fungal strains.
authors.affiliation: a Department of Chemistry , Institute of Natural Sciences, University of Gujrat , Gujrat , Pakistan .
authors.forename: Sajjad H
authors.initials: SH
authors.lastname: Sumrra
authors.affiliation: b Department of Chemistry , University of Sargodha , Bhakkar , Pakistan .
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.affiliation: c Institute of Chemical Sciences, Bahauddin Zakariya University , Multan , Pakistan .
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.affiliation: d Institute of Biochemistry and Biotechnology, University of the Punjab , Lahore , Pakistan .
authors.forename: Muhammad Safwan
authors.initials: MS
authors.lastname: Akram
authors.affiliation: e Department of Physics , COMSATS CIIT , Islamabad , Pakistan , and.
authors.forename: Javeed
authors.initials: J
authors.lastname: Akhtar
authors.affiliation: f Chemistry Department , College of Science, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Saad M
authors.initials: SM
authors.lastname: Al-Shehri
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009942:Organometallic Compounds; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc
keywords: Antibacterial; antifungal; carboxamides; crystal structures; metal(II) complexes