title: The effect of methyl palmitate on treatment of experimental asthma.
abstract: OBJECTIVE
  To determine the effects of methyl palmitate on murine model of chronic asthma.
  
  
  METHODS
  The experimental study was conducted in the animal laboratory of DokuzEylul University, Turkey, from October to December, 2012, and comprised BALB/c mice whowere divided into four equal groups: three experimental and one control group. All groups except the control group were sensitised and challenged with ovalbumin. Mice with experimentally-induced asthma in Group I received saline; Group II dexamethasone 1mg/kg; Group III methyl palmitate300mg/kg intraperitoneally three times per week in the last four weeks of the study period. Animals were sacrificed 24h after the last administration of study drugs. Histological findings of airways were evaluated by light microscopic examination. Blood samples from vena cava inferior were taken for measurement of interleukin-5 levels. SPSS 15 was used for statistical analysis.
  
  
  RESULTS
  The 28 female mice in the study were divided into 4 groups of 7(25%) each. The age range of the animals was 6-8weeks, and the weight range was 18-20g. All histological parameters and interleukin-5 levels of asthma in the Group III were significantly ameliorated compared to the Group I (p<0.05). All histological parameters and interleukin-5 levels were similar between Group III and Group II.
  
  
  CONCLUSIONS
  Methyl palmitate exhibited anti-inflammatory effects by resolving the histological changes and reducing the interleukin-5 levels in murine model of chronic asthma.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Temiz
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Mugla University, Mugla, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Kalemci
authors.affiliation: Department of Histology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Serap Cilaker
authors.initials: SC
authors.lastname: Micili
authors.affiliation: Department of Histology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Isil
authors.initials: I
authors.lastname: Tekmen
authors.affiliation: Department of Biochemistry, Health Sciences Institute of Adnan Menderes University, Aydin, Turkey.
authors.forename: Gulserap
authors.initials: G
authors.lastname: Yildiz
authors.affiliation: Department of Anatomy, Faculty of Medicine, Sifa University, Izmir, Turkey.
authors.forename: Tolgahan
authors.initials: T
authors.lastname: Acar
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ayik
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Aksun
authors.affiliation: Multidisciplinary Laboratory, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Akkoclu
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D003907:Dexamethasone / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D015848:Interleukin-5 / Q000276:immunology; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000633:toxicity; D010168:Palmitates / Q000494:pharmacology*
chemical_list: D005938:Glucocorticoids; D015848:Interleukin-5; D010168:Palmitates; D003907:Dexamethasone; D010047:Ovalbumin; C019012:methyl palmitate
keywords: Anti-inflammatory, Chronic asthma, Mouse, Interleukin-5, Methyl palmitate, Airway remodeling.