title: P300 event-related potential in abstinent methamphetamine-dependent patients.
abstract: BACKGROUND
  Substance use and abuse are characterized by biases in the attentional processing of substance-related stimuli. There are no event related potential (ERP)-based studies of attentional bias for substance-related cues among methamphetamine (MA) dependent patients. The study aimed to measure changes in P300 event-related potentials elicited by MA-related words in MA-dependent individuals at baseline and after 3 and 6 months of abstinence, examining the relationship of ERP changes to craving.
  
  
  METHODS
  26 MA-dependent patients (14 male) newly enrolled in two compulsory treatment centers in China and 29 healthy controls (15 male) were included in this study. At baseline (2-3 weeks in treatment) and after 3 and 6 months of abstinence from MA use, we obtained ERP data during a Stroop color-matching task using MA-related and neutral words. Self-reported craving was measured by a Visual Analog Scale (VAS).
  
  
  RESULTS
  Increased P300 amplitudes elicited by MA-related words were observed over left-anterior electrode sites. Abnormal P300 amplitudes declined to the normal levels of healthy controls at the end of 3 months of abstinence, and the decrease was maintained up to the end of 6 months of abstinence. The behavioral data did not show similar changes. The positive relationship between the changes of VAS scores for MA craving and the changes of P300 amplitudes over left anterior electrode sites elicited by MA-related words within the first 3 months was significant.
  
  
  CONCLUSIONS
  These findings highlight the potential use of ERP as an objective index to track changes in subjective MA craving among abstinent MA-dependent patients.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Haifeng
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Wenxu
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Hong
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Chuanwei
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Du
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Sun
authors.initials: S
authors.lastname: Haiming
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhikang
authors.affiliation: Shanghai Bureau of Drug Administration, 333 Wusong Road, Shanghai 200080, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Din
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China. Electronic address: jijunwang27@gmail.com.
authors.forename: Wang
authors.initials: W
authors.lastname: Jijun
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wanping Road, Shanghai 200030, PR China. Electronic address: drminzhao@gmail.com.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Min
mesh_terms: D000293:Adolescent; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000150:complications* / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000209:etiology; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine
keywords: Abstinence; Addiction Stroop; Craving; Event related potentials; Methamphetamine