title: Experimental approaches to vascularisation within tissue engineering constructs.
abstract: Tissue engineering opens up a new area to restore the function of damaged tissue or replace a defective organ. Common strategies in tissue engineering to repair and form new tissue containing a functional vascular network include the use of cells, growth factors, extracellular matrix proteins, and biophysical stimuli. Yet, formation of well-distributed, interconnected, and stable vascular network still remains challenging. In addition, anastomoses with host vasculature upon implantation and long-time survival of the new blood vessel in vivo are other critical issues to be addressed. This paper presents a brief review of recent advances in vascularization in vitro as well as in vivo for tissue engineering, along with suggestions for future research.
authors.affiliation: a Division of Biomedical Engineering, College of Engineering , University of Saskatchewan , 1A26, 57 Campus Drive, Saskatoon , SK S7N 5A9 , Canada.
authors.forename: Md
authors.initials: M
authors.lastname: Sarker
authors.forename: X B
authors.initials: XB
authors.lastname: Chen
authors.forename: D J
authors.initials: DJ
authors.lastname: Schreyer
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D006801:Humans; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000379:methods*
keywords: angiogenesis; biomaterial; growth factors; scaffold; vascularization; vasculogenesis