title: [Non-invasive diagnostic methods of fibrosis in chronic hepatitis C virus infection: their role in treatment indication, follow-up and assessment of prognosis].
abstract: Chronic hepatitis C virus infection associated with necroinflammation predisposes to liver fibrosis and cirrhosis, which lead to severe end-stage complications. Staging of fibrosis is of basic importance for the indication of antiviral treatment, for monitoring the response and predicting the prognosis of patients with hepatitis C virus related liver disease. Since liver biopsy, the "gold standard" diagnosis of fibrosis is invasive and it has some other limitations, non-invasive methods have been developed and widely used in the clinical practice. Serum biomarkers and physical approaches measuring liver stiffness by elastography as well as combination algorithms have been gradually been integrated into guidelines resulting in a reduction of the need for liver biopsy. The authors review these non-invasive fibrosis markers and discuss their role in the indication of treatment, follow-up, and assessment of prognosis of patients with chronic hepatitis C virus infection.
authors.affiliation: I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Klinikai Központ, Általános Orvostudományi Kar Pécs, Ifjúság u. 13., 7624.
authors.forename: Alajos
authors.initials: A
authors.lastname: Pár
authors.forename: Áron
authors.initials: Á
authors.lastname: Vincze
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pár
mesh_terms: D000465:Algorithms; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D001706:Biopsy; D004548:Elasticity; D054459:Elasticity Imaging Techniques; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000821:virology; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers
keywords: elastography; elasztográfia; fibrosis; follow-up; hepatitis C virus; hepatitis C-vírus; kezelés; követés; nem invazív eljárások; non-invasive assessment; prognosis; prognózis; serum biomarkers; szérumbiomarkerek; treatment