title: The Effect of Low Omega-3/Omega-6 Ratio on Auditory Nerve Conduction in Rat Pups.
abstract: The biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. This interaction extremely affects various functions. Lower consumption of omega-3 during gestation leads to various disorders, even in hearing. We aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. In this experimental study, the auditory brainstem response test was performed on 24-day-old rat (n=14). The rats were divided into case (low omega-3/omega-6 ratio during gestation and lactation) and control groups. Variables such as P1, P3, and P4 absolute latency period, interpeaks (P3-P4, P1-P3, and P1-P4), and P4/P1 amplitude ratio were measured. We found an increased P4 omega-3/omega-6 ratio in the group with a low omega-3/omega-6 ratio (P<0.01). No significant difference was observed in the P1 and P3 absolute latency period between the studied groups  (P>0.05).  Also, no significant difference was observed between the groups with respect to the P1-P3 interpeak latency (IPL) periods (P>0.05); while the P1-P4 and P3-P4 IPLs were significantly increased in the group with a low omega-3/omega-6 ratio (P<0.05). The P4/P1 amplitude ratio significantly decreased in the group with a low omega-3/omega-6 ratio (P<0.05). Results confirmed the negative effects of low omega-3/omega-6 ratio on the auditory system and hearing.
authors.affiliation: Department of Audiology , School of Rehabilitation, Tehran University of Medical Sciences,Tehran,Iran. s_farahani@tums.ac.ir.
authors.forename: Saeid
authors.initials: S
authors.lastname: Farahani
authors.affiliation: Department of Otolaryngology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND ENT Research Center, Tehran University of Medical Sciences, Tehran, Iran. s_farahani@tums.ac.ir.
authors.forename: Masoud
authors.initials: M
authors.lastname: Motasaddi Zarandy
authors.affiliation: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. hassanzadeh@tums.ac.ir.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Hassanzadeh
authors.affiliation: School of Health, Iran University of Medical Sciences, Tehran, Iran. farzadshidfar@yahoo.com.
authors.forename: Farzad
authors.initials: F
authors.lastname: Shidfar
authors.affiliation: Department of Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. jalaeish@tums.ac.ir.
authors.forename: Shohreh
authors.initials: S
authors.lastname: Jalaie
authors.affiliation: Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. v-rahimi@razi.tums.ac.ir.
authors.forename: Vida
authors.initials: V
authors.lastname: Rahimi
mesh_terms: D000818:Animals; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage*; D005260:Female; D006309:Hearing / Q000187:drug effects; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6