title: Relationship between serum uric acid levels and intrarenal hemodynamic parameters.
abstract: OBJECTIVE
  Hyperuricemia has been reported to affect renal hemodynamics in rat models. We evaluate the relationship between serum uric acid and intrarenal hemodynamic parameters in humans, utilizing the plasma clearance of para-aminohippurate (CPAH ) and inulin (Cin).
  
  
  METHODS
  Renal and glomerular hemodynamics were assessed by simultaneous measurement of CPAH and Cin in 58 subjects. Of these, 19 subjects were planned to provide a kidney for transplantation; 26 had diabetes without proteinuria; and 13 had mild proteinuria. Renal and glomerular hemodynamics were calculated using Gomez`s formulae.
  
  
  RESULTS
  Cin was more than 60 ml/min/1.73m(2) in all subjects. Serum uric acid levels correlated significantly with vascular resistance at the afferent arteriole (Ra) (r = 0.354, p = 0.006) but not with that of the efferent arteriole (Re). Serum uric acid levels (β = 0.581, p = <0.001) were significantly and independently associated with Ra after adjustment for several confounders (R(2) = 0.518, p = <0.001).
  
  
  CONCLUSIONS
  These findings suggest, for the first time in humans, that higher serum uric acid levels are associated significantly with Ra in subjects with Cin > 60 ml/min/1.73m(2). The increase in Ra in subjects with higher uric acid levels may be related to dysfunction of glomerular perfusion.
authors.affiliation: Department of Nephrology, Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Asahi-machi, Abeno-ku, Osaka, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Uedono
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tsuda
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishimura
authors.forename: Mari
authors.initials: M
authors.lastname: Yasumoto
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ichii
authors.forename: Akinobu
authors.initials: A
authors.lastname: Ochi
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Ohno
authors.forename: Shinya
authors.initials: S
authors.lastname: Nakatani
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Mori
authors.forename: Junji
authors.initials: J
authors.lastname: Uchida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakatani
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001794:Blood Pressure; D003928:Diabetic Nephropathies / Q000097:blood / Q000473:pathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000503:physiopathology*; D007444:Inulin; D007678:Kidney Glomerulus / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000097:blood; D012079:Renal Circulation; D014527:Uric Acid / Q000097:blood*; D014655:Vascular Resistance; D010130:p-Aminohippuric Acid / Q000378:metabolism
chemical_list: D014527:Uric Acid; D007444:Inulin; D010130:p-Aminohippuric Acid