title: Recent trends in orexin research--2010 to 2015.
abstract: Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A and orexin-B). The orexin-peptides are transported to areas of the brain regulating sleep-wake cycles, controlling food intake or modulating emotional states such as panic or anxiety. The orexin system, consisting of the two orexin-neuropeptides and two G-protein-coupled receptors (the orexin-1 and the orexin-2 receptor) is as well involved in reward and addictive behaviors. The review reflects on the most recent activities in the field of orexin research.
authors.affiliation: Drug Discovery Chemistry, Actelion Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland. Electronic address: christoph.boss@actelion.com.
authors.forename: Christoph
authors.initials: C
authors.lastname: Boss
authors.affiliation: Drug Discovery Pharmacology, Actelion Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland.
authors.forename: Catherine
authors.initials: C
authors.lastname: Roch
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D055808:Drug Discovery; D006801:Humans; D064446:Orexin Receptors / Q000032:analysis / Q000378:metabolism*; D000068797:Orexins / Q000032:analysis / Q000378:metabolism*; D012890:Sleep / Q000187:drug effects; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000378:metabolism*; D014851:Wakefulness / Q000187:drug effects
chemical_list: D064446:Orexin Receptors; D000068797:Orexins
keywords: Addiction; Anxiety; G-protein-coupled receptors; Hypothalamus; Orexin; Sleep disorders