title: CO-releasing Metal Carbonyl Compounds as Antimicrobial Agents in the Post-antibiotic Era.
abstract: The possibility of a "post-antibiotic era" in the 21st century, in which common infections may kill, has prompted research into radically new antimicrobials. CO-releasing molecules (CORMs), mostly metal carbonyl compounds, originally developed for therapeutic CO delivery in animals, are potent antimicrobial agents. Certain CORMs inhibit growth and respiration, reduce viability, and release CO to intracellular hemes, as predicted, but their actions are more complex, as revealed by transcriptomic datasets and modeling. Progress is hindered by difficulties in detecting CO release intracellularly, limited understanding of the biological chemistry of CO reactions with non-heme targets, and the cytotoxicity of some CORMs to mammalian cells.
authors.affiliation: From the Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
authors.forename: Lauren K
authors.initials: LK
authors.lastname: Wareham
authors.affiliation: From the Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield S10 2TN, United Kingdom r.poole@sheffield.ac.uk.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Poole
authors.affiliation: From the Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
authors.forename: Mariana
authors.initials: M
authors.lastname: Tinajero-Trejo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D002248:Carbon Monoxide / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D009942:Organometallic Compounds / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D002248:Carbon Monoxide
keywords: antibiotic resistance; antimicrobial agents; bacterial metabolism; carbon monoxide; heme; heme oxygenase; metal carbonyl compound; metal homeostasis; respiratory chain; transport metal