title: Specialised lipid mediators and their targets.
abstract: Inflammation is a complex process governed by the interaction of multiple cell types of the innate immune system and secreted mediators. Such mediators may act in a paracrine or autocrine fashion on target effector cells. An appropriate inflammatory response is characterised by dynamically regulated initiation, propagation and eventual resolution and restoration of tissue homeostasis. Dysregulation of any of these processes may underlie chronic inflammatory conditions such as atherosclerosis, diabetes and arthritis. Our growing understanding of the active processes underlying the resolution of inflammation suggest novel therapeutic paradigms. Here we review specialised lipid mediators and their targets which regulate such innate processes.
authors.affiliation: Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Crean
authors.affiliation: Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: catherine.godson@ucd.ie.
authors.forename: Catherine
authors.initials: C
authors.lastname: Godson
mesh_terms: D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D004281:Docosahexaenoic Acids / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology*; D044045:Lipoxins / Q000276:immunology*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D044045:Lipoxins; D004281:Docosahexaenoic Acids
keywords: Inflammation; Lipid mediators; Resolution