title: Tabletability Modulation Through Surface Engineering.
abstract: Poor powder tabletability is a common problem that challenges the successful development of high-quality tablet products. Using noncompressible microcrystalline cellulose beads, we demonstrate that surface coating is an effective strategy for modulating tabletability, almost at will, through judicious selection of coating material. This strategy has broad applicability as tabletability of such particles is dictated by the properties of the outermost layer coat regardless the nature of the core.
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, 55455.
authors.forename: Frederick
authors.initials: F
authors.lastname: Osei-Yeboah
authors.affiliation: Pharmaceutical Materials Science and Engineering Laboratory, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, 55455.
authors.forename: Changquan Calvin
authors.initials: CC
authors.lastname: Sun
mesh_terms: D002482:Cellulose / Q000737:chemistry; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods* / Q000639:trends; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010592:Pharmaceutic Aids / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D005079:Excipients; D010592:Pharmaceutic Aids; D013607:Tablets; D002482:Cellulose; D011205:Povidone; C109691:microcrystalline cellulose
keywords: compaction; compression; fluid-bed; hardness; materials science; polymers; polyvinylpyrrolidone; powder technology; tablet