title: Understanding peptide biology: The discovery and characterization of the novel hormone, neuronostatin.
abstract: The Human Genome Project provided the opportunity to use bioinformatic approaches to discover novel, endogenous hormones. Using this approach we have identified two novel peptide hormones and review here our strategy for the identification and characterization of the hormone, neuronostatin. We describe in this mini-review our strategy for determining neuronostatin's actions in brain, heart and pancreas. More importantly, we detail our deductive reasoning strategy for the identification of a neuronostatin receptor and our progress in establishing the physiological relevance of the peptide.
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA.
authors.forename: Gina L C
authors.initials: GL
authors.lastname: Yosten
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA.
authors.forename: Mollisa M
authors.initials: MM
authors.lastname: Elrick
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Salvatori
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Stein
authors.affiliation: Department of Pathology, Saint Louis University School of Medicine, USA.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Kolar
authors.affiliation: Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Biochemistry, Medical College of Wisconsin, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Corbett
authors.affiliation: Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, USA. Electronic address: samsonwk@slu.edu.
authors.forename: Willis K
authors.initials: WK
authors.lastname: Samson
mesh_terms: D001921:Brain / Q000378:metabolism*; D015894:Genome, Human; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D036361:Peptide Hormones / Q000235:genetics / Q000378:metabolism*
chemical_list: D036361:Peptide Hormones; C579289:neuronostatin, human
keywords: Hypothalamus; Neuropeptides; Pituitary; Receptors