title: Assessing Cutaneous Psoriasis Activity Using FDG-PET: Nonattenuation Corrected Versus Attenuation Corrected PET Images.
abstract: Psoriasis is a chronic inflammatory skin condition characterized by well-circumscribed erythematous plaques with thick silvery scale. Infiltration of inflammatory cells such as lymphocytes, neutrophils, and macrophages and epidermal cell proliferation within psoriatic lesions may result in selective FDG accumulation. We present a 55-year-old patient with a 30-year history of psoriasis. Nonattenuation corrected PET/CT images demonstrated significant cutaneous FDG uptake corresponding to clinically apparent psoriatic lesions. However, in attenuation corrected (AC) FDG-PET images, the signal was substantially diminished and minimally detectable. Nonattenuation corrected FDG-PET images may be useful and preferable to AC images in assessing skin inflammation in psoriasis.
authors.affiliation: From the *Robert Wood Johnson Medical School, Piscataway, NJ; †Department of Dermatology, Perelman School of Medicine; and ‡Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA.
authors.forename: Anshika
authors.initials: A
authors.lastname: Bakshi
authors.forename: Saeid
authors.initials: S
authors.lastname: Gholami
authors.forename: Abass
authors.initials: A
authors.lastname: Alavi
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gelfand
authors.forename: Junko
authors.initials: J
authors.lastname: Takeshita
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011565:Psoriasis / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18