title: Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy.
abstract: BACKGROUND
  Several studies have demonstrated that renal transplantation in HIV positive patients is both safe and effective. However, none of these studies have specifically examined outcomes in patients with HIV-associated nephropathy (HIVAN).
  
  
  METHODS
  Medical records of all HIV-infected patients who underwent kidney transplantation at Johns Hopkins Hospital between September 2006 and January 2014 were reviewed. Data was collected to examine baseline characteristics and outcomes of transplant recipients with HIVAN defined pathologically as collapsing focal segmental glomerulosclerosis (FSGS) with tubulo-interstitial disease.
  
  
  CONCLUSIONS
  During the study period, a total of 16 patients with HIV infection underwent renal transplantation. Of those, 11 patients were identified to have biopsy-proven HIVAN as the primary cause of their end stage renal disease (ESRD) and were included in this study. They were predominantly African American males with a mean age of 47.6 years. Seven (64%) patients developed delayed graft function (DGF), and 6 (54%) patients required post-operative dialysis within one week of transplant. Graft survival rates at 1 and 3 years were 100% and 81%, respectively. Acute rejection rates at 1 and 3 years were 18% and 27%, respectively. During a mean follow up of 3.4 years, one patient died.
  
  
  CONCLUSIONS
  Acute rejection rates in HIVAN patients in this study are higher than reported in the general ESRD population, which is similar to findings from prior studies of patients with HIV infection and ESRD of various causes. The high rejection rates appear to have no impact on short or intermediate term graft survival.
authors.affiliation: Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin, United States of America.
authors.forename: Sana
authors.initials: S
authors.lastname: Waheed
authors.affiliation: Ain Shams Faculty of Medicine, Cairo, Egypt.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Sakr
authors.affiliation: Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Neha D
authors.initials: ND
authors.lastname: Chheda
authors.affiliation: Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Lucas
authors.affiliation: Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Michelle
authors.initials: M
authors.lastname: Estrella
authors.affiliation: Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Fine
authors.affiliation: Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
authors.forename: Mohamed G
authors.initials: MG
authors.lastname: Atta
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000601:surgery*; D000328:Adult; D000368:Aged; D051799:Delayed Graft Function / Q000453:epidemiology*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D015497:HIV-1; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged