title: Psychosis, Mood and Behavioral Disorders in Usher Syndrome: Review of the Literature.
abstract: The aim of this review is to focus the current knowledge about mental and behavioral disorders in Usher syndrome. Previous studies described the presence of various mental disorders associated with Usher syndrome, suggesting possible mechanisms of association between these disorders. The most common manifestations are schizophrenia-like disorder and psychotic symptoms. Mood and behavioral disorders are rarely described, and often are associated with more complex cases in co-occurrence with other psychiatric disorders. Neuroimaging studies reported diffuse involvement of central nervous system (CNS) in Usher patients, suggesting a possible role of CNS damage in the pathogenesis of psychiatric manifestations. Genetic hypothesis and stress-related theories have also been proposed.
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Domanico
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fragiotta
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cutini
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina, Italy.
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Grenga
authors.affiliation: Department of Medical-Surgical Sciences and Biotechnologies, U.O.S.D. Ophthalmology, Sapienza University of Rome, Terracina, Italy.
authors.forename: Enzo Maria
authors.initials: EM
authors.lastname: Vingolo
keywords: Hearing Loss; Psychosis; Retinitis Pigmentosa; Schizophrenia; Usher Syndrome