title: SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment.
abstract: Silent mating type information regulation 1 (SIRT1) is implicated in tumorigenesis through its effect on autophagy. In gastric cancer (GC), SIRT1 is a marker for prognosis and is involved in cell invasion, proliferation, epithelial-mesenchymal transition (EMT) and drug resistance. Autophagy can function as a cell-survival mechanism or lead to cell death during the genesis and treatment of GC. This functionality is determined by factors including the stage of the tumor, cellular context and stress levels. Interestingly, SIRT1 can regulate autophagy through the deacetylation of autophagy-related genes (ATGs) and mediators of autophagy. Taken together, these findings support the need for continued research efforts to understand the mechanisms mediating the development of gastric cancer and unveil new strategies to eradicate this disease.
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Guanglin
authors.initials: G
authors.lastname: Qiu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xuqi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Che
authors.affiliation: Xi'an Health School, Xi'an 710054, Shaanxi Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Shicai
authors.initials: S
authors.lastname: He
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
authors.forename: Zongliang
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Shaanxi Friendship Hospital, Xi'an 710068, Shaanxi Province, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Pang
authors.affiliation: Department of General Surgery, The First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. Electronic address: linnet@mail.xjtu.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Fan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use; D001343:Autophagy / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D063646:Carcinogenesis / Q000187:drug effects / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D056564:Sirtuin 1 / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D009363:Neoplasm Proteins; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Autophagy; Gastric cancer; Silent mating type information regulation 1; Tumor promoter; Tumor suppressor