title: Influence of ethanol content in the precipitation medium on the composition, structure and reactivity of magnesium-calcium phosphate.
abstract: Biocompatible amorphous magnesium calcium phosphate (AMCP) particles were synthesized using ethanol in precipitation medium from moderately supersaturated solution at pH10. Some synthesis parameters such as, (Mg+Ca):P, Mg:Ca ratio and different drying methods on the structure and stability of as-produced powder was studied and characterized using SEM, XRD and cell cytocompatibility. The results showed that depending on the Mg(2+) concentration, nano crystalline Struvite (MgNH4PO4·6H2O) can also be alternatively formed. However, the as-formed AMCP preserved its amorphous structure after 7 days of incubation in SBF for tested phosphate concentration, and equally ionic concentration of magnesium and calcium.
authors.affiliation: Department of Bioengineering, University of Toledo, Toledo, OH, USA. Electronic address: Elham.Babaie@rockets.utoledo.edu.
authors.forename: Elham
authors.initials: E
authors.lastname: Babaie
authors.affiliation: Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Bioengineering, University of Toledo, Toledo, OH, USA.
authors.forename: Boren
authors.initials: B
authors.lastname: Lin
authors.affiliation: Department of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, OH, USA; Department of Surgery (Dentistry), University of Toledo, Toledo, OH, USA.
authors.forename: Sarit B
authors.initials: SB
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002130:Calcium Phosphates / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D011232:Chemical Precipitation; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry*; D017616:Magnesium Compounds / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D010710:Phosphates / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D017616:Magnesium Compounds; D010710:Phosphates; D000431:Ethanol; C030781:magnesium phosphate; C020243:calcium phosphate
keywords: Amorphous phase; Calcium phosphate; Ethanol; Magnesium phosphate