title: Amino acid-catalyzed formation of 2-vinylfuran from lipid-derived 4-oxo-2-hexenal.
abstract: The formation of 2-vinylfuran from the corresponding 4-oxo-2-hexenal (OHE, a lipid oxidation product) under the catalysis of amino acid were studied. The effects of amino acids, reaction temperature, reaction time, water content, pH, metallic ions and some food additives on the formation of 2-vinylfuran were investigated. Amino acids promoted the formation of 2-vinylfuran except aspartic acid, histidine and glutamine. Cysteine showed the strongest catalytic activity among the amino acids tested. Further investigation indicated that the intermediate 1-(furan-2-yl)ethanol played an very important role in the formation of 2-vinylfuran. Both higher temperature and acidic condition favored the transformation of OHE into 2-vinylfuran. The reaction time, water content, metallic ions and food additives also influenced the reaction to certain extent.
authors.affiliation: Department of Chemistry, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Chemistry, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Jimei
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Chemistry, Huazhong Agricultural University, Wuhan 430070, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: jianghong0066@126.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D001669:Biochemical Phenomena; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D005663:Furans; D008055:Lipids; C027684:2-vinylfuran; C051750:2-hexenal
keywords: 1-(Furan-2-yl)ethanol (PubChem CID: 107243); 2-Vinylfuran; 2-Vinylfuran (PubChem CID: 73881); 4-Oxo-2-hexenal; 4-Oxo-2-hexenal (PubChem CID: 3014106); Amino acids; Lipid oxidation