title: The Arabidopsis epitranscriptome.
abstract: The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps reveal that thousands of Arabidopsis mRNAs are methylated. Arabidopsis is likely to be a model of wide utility in understanding the biological impacts of the epitranscriptome. We review recent progress and look ahead with questions awaiting answers to reveal an entire layer of gene regulation that has until recently been overlooked.
authors.affiliation: School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK. Electronic address: Rupert.Fray@nottingham.ac.uk.
authors.forename: Rupert G
authors.initials: RG
authors.lastname: Fray
authors.affiliation: Division of Plant Sciences, College of Life Sciences, University of Dundee, Cell and Molecular Sciences, James Hutton Institute, Invergowrie DD2 5DA, Scotland, UK. Electronic address: g.g.simpson@dundee.ac.uk.
authors.forename: Gordon G
authors.initials: GG
authors.lastname: Simpson
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D018506:Gene Expression Regulation, Plant; D008745:Methylation; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome
chemical_list: D012333:RNA, Messenger