title: DNA, the biopolymer as a target material for metalloinsertors: From chemistry to preclinical implications.
abstract: The coordination of therapeutically interesting designed complexes of stoichiometry [ML(Met)Cl2] [where M=Cu(II), Co(II), Ni(II), Mn(II) and Zn(II), L=benzylidene-4-aminoantipyrine and Met=methionine] has been ascertained on the basis of physicochemical techniques. Their interaction with CT DNA reveals that they are good intercalators. The anticancer mechanism of our complexes is documented from their enhanced DNA splitting personalities under physiological conditions. To reveal the chemotherapeutic action of these complexes, we explored the inflammatory response, analgesic and antioxidant activities. Moreover, all the complexes show good antimicrobial activity against few bacterial and fungal strains. Our study has identified the mechanism of action of these complexes on inhibiting tumor cells and suggested that they have great potential as novel anticancer agents.
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India. Electronic address: drn_raman@yahoo.co.in.
authors.forename: N
authors.initials: N
authors.lastname: Raman
authors.affiliation: Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.
authors.forename: M
authors.initials: M
authors.lastname: Selvaganapathy
authors.affiliation: Department of Chemistry, PSR Engineering College, Sivakasi 626 140, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Sudharsan
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D004487:Edema; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology; D019216:Metals, Heavy / Q000737:chemistry*; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D012545:Schiff Bases
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D007364:Intercalating Agents; D019216:Metals, Heavy; D012545:Schiff Bases; D004247:DNA
keywords: Analgesic activity; Anticancer mechanism; Inflammatory response; Non-covalent binding