title: Predicting visual acuity from the structure of visual cortex.
abstract: Three decades ago, Rockel et al. proposed that neuronal surface densities (number of neurons under a square millimeter of surface) of primary visual cortices (V1s) in primates is 2.5 times higher than the neuronal density of V1s in nonprimates or many other cortical regions in primates and nonprimates. This claim has remained controversial and much debated. We replicated the study of Rockel et al. with attention to modern stereological precepts and show that indeed primate V1 is 2.5 times denser (number of neurons per square millimeter) than many other cortical regions and nonprimate V1s; we also show that V2 is 1.7 times as dense. As primate V1s are denser, they have more neurons and thus more pinwheels than similar-sized nonprimate V1s, which explains why primates have better visual acuity.
authors.affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037; Kavli Institute for Brain and Mind, University of California, San Diego, CA 92093.
authors.forename: Shyam
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037;
authors.forename: C Nikoosh
authors.initials: CN
authors.lastname: Carlo
authors.affiliation: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037; Kavli Institute for Brain and Mind, University of California, San Diego, CA 92093 stevens@salk.edu.
authors.forename: Charles F
authors.initials: CF
authors.lastname: Stevens
mesh_terms: D000818:Animals; D006801:Humans; D014792:Visual Acuity; D014793:Visual Cortex / Q000033:anatomy & histology* / Q000502:physiology
keywords: V1; pinwheels; primates; vision; visual acuity