title: The application of nanomaterials in controlled drug delivery for bone regeneration.
abstract: Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part.
authors.affiliation: Department of Orthopedics, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Shi
authors.affiliation: Department of General Surgery, Zhangbei Hospital, Zhangbei, 076450, China.
authors.forename: Wenbao
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Tianxiao
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Department of Civil Engineering-Engineering Mechanics, University of Arizona, Tucson, Arizona, 85721.
authors.forename: Katerina E
authors.initials: KE
authors.lastname: Aifantis
authors.affiliation: Department of Orthopedics, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Orthopedics, The First Hospital of Hebei Medical University, Shijiazhuang, 050031, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lin
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
authors.affiliation: State Key Laboratory of New Ceramic and Fine Processing, Tsinghua University, Beijing, 100084, China.
authors.forename: Qingling
authors.initials: Q
authors.lastname: Feng
authors.affiliation: State Key Laboratory of New Ceramic and Fine Processing, Tsinghua University, Beijing, 100084, China.
authors.forename: Fu-zhai
authors.initials: FZ
authors.lastname: Cui
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D001861:Bone Regeneration / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000633:toxicity; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations
keywords: bone regeneration; controlled drug delivery; nanomaterials