title: Determination of suspected fragrance allergens extended list by two-dimensional gas chromatography-mass spectrometry in ready-to-inject samples.
abstract: A new strategy was developed to elucidate and quantify 56 (69 analytes including isomers) suspected chemically defined fragrance allergens in perfumes that were recently targeted by the Scientific Committee on Consumer Safety (SCCS). Samples were analyzed with a two-dimensional gas chromatography-quadrupole mass spectrometry system (GC-GC-MS). Method performance was evaluated by the accuracy profile approach to determine uncertainties around the regulation limit of 10mg/kg. This strategy was finally applied to 62 commercialized perfumes, analyzed in the routine workflow. Depending on the matrix, an acceptable result was obtained for 88-100% of the target analytes, which means that results were accurately defined under or above 10mg/kg. This method saves considerable time for complete analysis and could be adopted for routine analysis due to its ruggedness and cost effectiveness.
authors.affiliation: Chanel, Laboratoire Recherche et Analyses, 135 Avenue Charles de Gaulle, 92200 Neuilly-sur-Seine, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Rey
authors.affiliation: Chanel, Laboratoire Recherche et Analyses, 135 Avenue Charles de Gaulle, 92200 Neuilly-sur-Seine, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Corbi
authors.affiliation: Chanel, Laboratoire Recherche et Analyses, 135 Avenue Charles de Gaulle, 92200 Neuilly-sur-Seine, France. Electronic address: chrisophe.peres@chanel-corp.com.
authors.forename: Christophe
authors.initials: C
authors.lastname: Pérès
authors.affiliation: Chanel, Laboratoire Recherche et Analyses, 135 Avenue Charles de Gaulle, 92200 Neuilly-sur-Seine, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: David
mesh_terms: D000485:Allergens / Q000032:analysis*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D057230:Limit of Detection; D010476:Perfume / Q000737:chemistry*
chemical_list: D000485:Allergens; D010476:Perfume
keywords: Accuracy profile; Deans switch; Fragrances; GC–GC–FID–MS; Method validation; Quantification; Two-dimensional gas chromatography; Volatile allergens analyses