title: Invasive mole in a perimenopausal woman: a case report and systematic review.
abstract: OBJECTIVE
  Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumors. We present a case of a perimenopausal woman with invasive mole. A systematic review was performed to identify reports on GTD in older women and to determine adequate treatment options.
  
  
  METHODS
  A 51-year-old perimenopausal woman was admitted to hospital with abdominal feeling of pressure and nausea. Diagnostic curettage revealed hydatidiform mole. She also presented symptomatic hyperthyroidism with hypertensive blood pressure and uneasiness. After treatment with beta blockers and carbimazole, the patient underwent abdominal hysterectomy and bilateral oophorosalpingectomy. Histopathological examination confirmed an invasive hydatidiform mole (IHM). Serum β-hCG has decreased from initially 300,000-100 unit/L after 4 weeks.
  
  
  METHODS
  A systematic review was performed to identify all prior cases of GTD in women over 50. We searched in Medline, The Cochrane Library and Embase, to identify any articles published in the English language after 1970 and before Oct 31, 2013 pertaining to GTD in older woman (50 years or older).
  
  
  RESULTS
  Ten records were included in the systematic review, involving 203 cases of trophoblastic disease in older women. Although the diagnosis of GTD in older women is rare, it should be considered especially in patients with suspicious intrauterine findings in transvaginal ultrasound examinations. Different treatments were performed. In a limited number of reports, older women with GTD underwent initial hysterectomy. Benefits are avoidance of chemotherapy-induced toxicity and reduced risk of recurrence. Hysterectomy should be performed by an experienced surgeon.
  
  
  CONCLUSIONS
  It is concluded that GTD is very rare in peri- or postmenopausal women. Treatment has to be individualized, and hysterectomy can be considered as an appropriate option.
authors.affiliation: Department of Gynecology and Obstetrics, University Medical Center, Caritas Hospital St. Josef, University of Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany. sophievonwelser@aol.com.
authors.forename: Sophie Freifrau
authors.initials: SF
authors.lastname: von Welser
authors.affiliation: Department of Internal Medicine III, University Medical Center, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Grube
authors.affiliation: Department of Gynecology and Obstetrics, University Medical Center, Caritas Hospital St. Josef, University of Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Ortmann
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D003475:Curettage; D005260:Female; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000473:pathology* / Q000601:surgery; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D007044:Hysterectomy; D008875:Middle Aged; D047648:Perimenopause; D011247:Pregnancy; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D002231:Carbimazole
keywords: Gestational trophoblastic disease (GTD); Hysterectomy; Invasive mole; Perimenopausal