title: The potential of nanofibers in tissue engineering and stem cell therapy.
abstract: Electrospinning is a technique in which materials in solution are shaped into continuous nano- and micro-sized fibers. Combining stem cells with biomaterial scaffolds and nanofibers affords a favorable approach for bone tissue engineering, stem cell growth and transfer, ocular surface reconstruction, and treatment of congenital corneal diseases. This review seeks to describe the current examples of the use of scaffolds in stem cell therapy. Stem cells are classified as adult or embryonic stem (ES) cells, and the advantages and drawbacks of each group are detailed. The nanofibers and scaffolds are further classified in Tables I and II , which describe specific examples from the literature. Finally, the current applications of biomaterial scaffolds containing stem cells for tissue engineering applications are presented. Overall, this review seeks to give an overview of the biomaterials available for use in combination with stem cells, and the application of nanofibers in stem cell therapy.
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Molecular Medicine , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|d Iran National Science Foundation: INSF , Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Gholizadeh-Ghaleh Aziz
authors.affiliation: c Department of Food Science and Technology , Islamic Azad University , Tabriz , Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Gholizadeh-Ghaleh Aziz
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|d Iran National Science Foundation: INSF , Iran.|e Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
mesh_terms: D000328:Adult; D053687:Adult Stem Cells / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D003316:Corneal Diseases / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000066449:Human Embryonic Stem Cells / Q000378:metabolism / Q000637:transplantation*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
keywords: biomaterial scaffolds; electrospinning; nanofiber; stem cells