title: Diffuse Large B-Cell Lymphoma of the Gingiva in a Patient on Long-Term Use of Methotrexate Being Treated for Psoriasis.
abstract: An 81-year-old male patient presented with a large gingival ulcer of 2 months' duration. He had been taking methotrexate, a potent anti-inflammatory/immunosuppressant, for the past 50 years to treat psoriasis. A biopsy revealed diffuse large B-cell lymphoma Epstein-Barr virus positive. Remission occurred after discontinuing the medication. Clinicians noting a non-healing ulcer in the mucosal or keratinized tissue of the oral cavity of a patient on immunosuppressants should perform a biopsy examination to rule out lymphoma or other malignancy.
authors.affiliation: Private Practice in Periodontics, Tucker, Georgia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Shapiro
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D003879:Dermatologic Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005887:Gingival Neoplasms / Q000139:chemically induced*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D008727:Methotrexate