title: Association study between 5-HT2A and NET gene polymorphisms and recurrent major depression disorder in Chinese Han population.
abstract: A functional NET T-182C polymorphism (rs2242446) in the promoter region, a synonymous polymorphisms G1287A in the exon 9(rs5569) and a functional serotonin 2A (5-HT2A) receptor (rs6311) genes in the promoter region were associated with MDD in different populations. However, few studies have focused on the relationship between these three polymorphisms and recurrent MDD patients in Chinese Han population. Three hundred MDD patients (112 males, 188 females) and three hundre unrelated healthy controls were enrolled in the study. POST-PCR ligase detection reaction genotype assay method was used for the genotypic analyses. There existed significant differences both in the frequencies of alleles and genotypes between patients and controls for the 5-HT2A receptor gene polymorphism (χ2=9.267, p=0.01 for genotype; χ2=7.615,p=0.006 for allele). No difference in genotype and allele distribution of G1287A, T182C were found in MDD patients and controls. Our results suggest that the rs6311 polymorphism seems to be the susceptibility factor in etiology of recurrent MDD. In conclusion, 5-HT2A receptor gene variants may be involved in the etiology of MDD, although the results must be verified in larger samples and different ethnicities.
authors.affiliation: ental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, P.R. China.
authors.forename: Suxia
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
authors.forename: Hengfen
authors.initials: H
authors.lastname: Li
authors.affiliation: Prevention and Health Department, Zhengzhou Ninth People's Hospital, Zhengzhou, Henan Province, P. R. China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Lou
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, He Nan University of Traditional Chinese medicine, Zhengzhou, Henan Province, P. R. China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
authors.forename: Jianyue
authors.initials: J
authors.lastname: Pang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, P.R. China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Sui
authors.affiliation: Mental Health Institute of The Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan Province, P.R. China.
authors.forename: Guangrong
authors.initials: G
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005091:Exons; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012008:Recurrence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; D044402:Receptor, Serotonin, 5-HT2A; C493227:SLC6A2 protein, human