title: Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo.
abstract: This study is to explore the osteogenesis potential of the human periodontal ligament stem cells (hPDLSCs) induced by naringin in vitro and in vitro. The results confirmed that 1 μM naringin performs the best effect and a collection of bone-related genes (RUNX2, COL1A2, OPN, and OCN) had significantly higher expression levels compared to the control group. Furthermore, a typical trabecular structure was observed in vivo, surrounded by a large amount of osteoblasts. These results demonstrated that naringin, at a concentration of 1 μM, can efficiently promote the proliferation and differentiation of hPDLSCs both in vitro and in vivo.
authors.affiliation: School of Life Sciences, Lanzhou University, Lanzhou, Gansu, China ; Department of Oral Implantology, School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Yin
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Wenxiao
authors.initials: W
authors.lastname: Cheng
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Zishun
authors.initials: Z
authors.lastname: Qin
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Hongdou
authors.initials: H
authors.lastname: Yu
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Zhanhai
authors.initials: Z
authors.lastname: Yu
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
authors.affiliation: School/Hospital of Stomatology, Lanzhou University, No. 199 Donggang West Road, Chengguan, Lanzhou, Gansu, China.
authors.forename: Kemo
authors.initials: K
authors.lastname: Sun
authors.affiliation: Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, No. 99 Haike Road, Pudong, Shanghai 201210, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang