title: Development and Application of O-(Trimethylsilyl)aryl Fluorosulfates for the Synthesis of Arynes.
abstract: A class of o-(trimethylsilyl)aryl fluorosulfates was synthesized by a concise method and successfully used as aryne precursors for the first time. Different trapping agents such as azides, furans, and acyl acetoacetates could successfully react with the aryne precursors under mild conditions with good to excellent yields.
authors.affiliation: †Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Chen
authors.affiliation: †Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Yu
authors.affiliation: †Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Xu
authors.affiliation: †Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: ‡School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: †Institute of New Drugs Design and Synthesis, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000090:Acetoacetates / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000090:Acetoacetates; D001386:Azides; D014297:Trimethylsilyl Compounds