title: Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine Dihydrochloride/Poly(lactic-co-glycolic acid).
abstract: Titanium (Ti) implants with long-term antibacterial ability and good biocompatibility are highly desirable materials that can be used to prevent implant-associated infections. In this study, titania nanotubes (TNTs) were synthesized on Ti surfaces through electrochemical anodization. Octenidine dihydrochloride (OCT)/poly(lactic-co-glycolic acid) (PLGA) was infiltrated into TNTs using a simple solvent-casting technique. OCT/PLGA-TNTs demonstrated sustained drug release and maintained the characteristic hollow structures of TNTs. TNTs (200 nm in diameter) alone exhibited slight antibacterial effect and good osteogenic activity but also evidently impaired adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs). OCT/PLGA-TNTs (100 nm in diameter) supported BMSC adhesion and proliferation and showed good osteogenesis-inducing ability. OCT/PLGA-TNTs also exhibited good long-term antibacterial ability within the observation period of 7 d. The synthesized drug carrier with relatively long-term antibacterial ability and enhanced excellent biocompatibility demonstrated significant potential in bone implant applications.
authors.affiliation: School of Stomatology, Fujian Medical University, Fuzhou, Fujian 350000, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Oral Medicine, Xiamen Medical College, Xiamen, Fujian 361000, China.
authors.forename: Yingzhen
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Department of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, Fujian 350002, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wu
authors.affiliation: Department of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, Fujian 350002, China.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Huang
authors.affiliation: School of Stomatology, Fujian Medical University, Fuzhou, Fujian 350000, China.
authors.forename: Sijia
authors.initials: S
authors.lastname: Huang
authors.affiliation: School of Stomatology, Fujian Medical University, Fuzhou, Fujian 350000, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, Fujian 350002, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Chen
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D007097:Imines; D019344:Lactic Acid / Q000737:chemistry; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D043942:Nanotubes / Q000009:adverse effects* / Q000737:chemistry; D010012:Osteogenesis / Q000187:drug effects*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011725:Pyridines / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D007097:Imines; D011725:Pyridines; C009495:titanium dioxide; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014025:Titanium; C034213:octenidine