title: Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analysis.
abstract: BACKGROUND
  Studies investigating the associations between transcription factor 4 (TCF4) genetic polymorphisms and Fuchs' endothelial dystrophy (FED) have reported controversial results. Therefore, this meta-analysis aims to clarify the effects of TCF4 polymorphisms on FED risk.
  
  
  METHODS
  A meta-analysis was conducted to assess the association between four single nucleotide polymorphisms (SNPs) inTCF4 and the risk of FED. Relevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Pooled odds ratio (OR) and 95 % confidence interval (CI) were calculated using the random-effects model.
  
  
  RESULTS
  Thirteen studies were included in this systematic review and meta-analysis. The pooled results showed that there was a strong positive association between the TCF4 rs613872 polymorphism and FED risk in all the genetic models tested (G allele vs. T allele: OR = 4.19, 95 % CI = 3.53-4.97; GG vs.
  OR = 4.27, 95 % CI = 2.54-7.19; GG/GT vs. TT: OR = 6.29, 95 % CI = 4.23-8.93; GG VS. TT: OR = 10.64, 95 % CI = 5.28-21.41; GT VS. TT: OR = 6.08, 95 % CI = 4.28-8.64). Statistic evidence was also detected for a significant association between three other SNPs and the risk of FED.
  
  
  CONCLUSIONS
  This meta-analysis suggested a genetic association between four TCF4 polymorphisms (rs613872, rs2286812, rs17595731, and rs9954153) and the risk of FED.
authors.affiliation: Beijng Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, China. 2770688345@qq.com.|Department of Ophthalmology, Beijng di tan Hospital, Capital Medical University, Beijing, China. 2770688345@qq.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Beijng Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing, 100730, China. drpengxy@163.com.
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, Beijng di tan Hospital, Capital Medical University, Beijing, China. sunhuiyu123@126.com.
authors.forename: HuiYu
authors.initials: H
authors.lastname: Sun
mesh_terms: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000235:genetics*; D005642:Fuchs' Endothelial Dystrophy / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D000073940:Transcription Factor 4; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; C532096:TCF4 protein, human; D000073940:Transcription Factor 4; D014157:Transcription Factors