title: Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy.
abstract: OBJECTIVE
  To investigate the hypothesis that high serum levels of omentin, an adipokine with anti-inflammatory, insulin-sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy.
  
  
  METHODS
  The association between serum omentin level and polyneuropathy was estimated in people aged 61-82 years with Type 2 diabetes (47 with and 168 without polyneuropathy) from the population-based KORA F4 study. The presence of clinical diabetic sensorimotor polyneuropathy was defined as bilateral impairment of foot vibration perception and/or foot pressure sensation. Omentin levels were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum omentin level was inversely associated with polyneuropathy after adjustment for age, sex, height, waist circumference, hypertension, total cholesterol, smoking, alcohol intake and physical activity [odds ratio 0.45 (95% CI 0.21-0.98); P = 0.043]. Although omentin was positively correlated with adiponectin (r = 0.55, P < 0.0001) and inversely with tumour necrosis factor-α (r = -0.30, P = 0.019), additional adjustment for adiponectin and tumour necrosis factor-α had little impact on the association.
  
  
  CONCLUSIONS
  Serum levels of omentin are reduced in people with Type 2 diabetes and diabetic sensorimotor polyneuropathy, independently of established risk factors of polyneuropathy. This association is only partially explained by biomarkers of subclinical inflammation.
authors.affiliation: Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|German Centre for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Herder
authors.affiliation: Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: B W C
authors.initials: BW
authors.lastname: Bongaerts
authors.affiliation: German Centre for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.|Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|Department of Endocrinology, Ghent University Hospital, Ghent, Belgium, Germany.
authors.forename: D M
authors.initials: DM
authors.lastname: Ouwens
authors.affiliation: Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Rathmann
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Heier
authors.affiliation: Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|German Centre for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Carstensen-Kirberg
authors.affiliation: Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.|German Centre for Diabetes Research (DZD e.V.), Partner Neuherberg, Neuherberg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Thorand
authors.affiliation: Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|German Centre for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.|Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Roden
authors.affiliation: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Meisinger
authors.affiliation: Institute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.|German Centre for Diabetes Research (DZD e.V.), Partner Düsseldorf, Germany.|Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Ziegler
mesh_terms: D052242:Adiponectin / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000097:blood* / Q000453:epidemiology; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D058851:GPI-Linked Proteins / Q000097:blood; D005858:Germany / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D011115:Polyneuropathies / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha