title: FOXM1 and its Oncogenic Signaling in Gastric Cancer.
abstract: The transcription factor FOXM1 is overexpressed in many human cancers, including liver, stomach, prostate, brain, breast, lung, colon, pancreas, cervix, ovary and nervous system. Recent data have demonstrated that FOXM1 is involved in cell initiation, progression, and metastasis and in responses to anticancer drugs. In this review, the effects of FOXM1 on gastric cancer, especially the function and regulation of FOXM1 in tumorigenesis and clinical chemotherapy, will be summarized and discussed together with recent relevant patents on the role of FOXM1 in tumor therapy.
authors.forename: Hanying
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Haining Road, Shanghai 200080, P.R. China. richard-hc@hotmail.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
mesh_terms: D063646:Carcinogenesis; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000503:physiopathology
chemical_list: C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors