title: Clinical significance of CD70 expression on T cells in human T-lymphotropic virus type-1 carriers and adult T cell leukemia/ lymphoma patients.
abstract: Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATL). Miscellaneous host immune surveillance systems control T-cell growth/leukemogenesis during HTLV-1 infection. We characterized CD70 and CD27 expression on lymphocytes of HTLV-1 carriers and patients with ATL (study approved by the local Medical Ethical Committee). High CD70 expression was observed on CD4 + CD25+ T cells from patients with acute-type ATL, while patients with smoldering- or chronic-type ATL and HTLV-1 carriers exhibited lower expression. Furthermore, significantly higher CD27 expression was observed on HTLV-1-specific CTLs. We found an association between CD70 expression on CD4 + T cells and HTLV-1 infection; increased CD70 expression was observed after exposure to Tax. Moreover, addition of anti-CD70 antibodies enhanced the CD107a surface mobilization of HTLV-1 Tax-specific CTLs following Tax-peptide stimulation in the PBMCs of carriers. These data demonstrate the important role of the CD70/CD27 axis in immune responses in HTLV-1 carriers and ATL patients.
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Masamoto
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshimitsu
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Kuroki
authors.affiliation: b Department of Regional Environment , Faculty of Regional Sciences, Tottori University , Yonago, Tottori , Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Horai
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Chibueze Chioma
authors.initials: CC
authors.lastname: Ezinne
authors.affiliation: c Department of Biochemistry , Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma Jonanku , Fukuoka , Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kozako
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Hachiman
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Kamada
authors.affiliation: d Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Baba
authors.affiliation: a Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University , Kagoshima , Japan.
authors.forename: Naomichi
authors.initials: N
authors.lastname: Arima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D053282:CD27 Ligand / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D005260:Female; D015870:Gene Expression; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000209:etiology* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D053282:CD27 Ligand; D016356:Gene Products, tax; C514970:tax protein, Human T-lymphotrophic virus 1
keywords: Adult T cell leukemia/lymphoma; CD27; CD70; Tax; human T-cell lymphotropic virus type-1 (HTLV-1)