title: Potential signal pathway between all-trans retinoic acid and LMX1B in hypoxia-induced renal tubular epithelial cell injury.
abstract: All-trans retinoic acid (ATRA), an active metabolite of vitamin A, exerts various effects on physiological processes such as cell growth, differentiation, apoptosis and inflammation. LMX1B, a developmental LIM-homeodomain transcription factor, is widely expressed in vertebrate embryos, and it takes part in the development of diverse structures such as limbs, kidneys, eyes, brains, etc. Renal tubular epithelial cell culture was performed, and mRNA and protein expression of some factors were detected. We recently demonstrated that ATRA up-regulated the LMX1B, and down-regulated the transforming growth factor-β1, collagen IV and fibronectin in a hypoxia/reoxygenation (H-R) injury system in renal tubular epithelial cells (RTEC). In conclusion, ATRA acts as a positive regulator of LMX1B in H-R RTEC.
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , P.R. China .
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.affiliation: b Department of Experimental Pathology , The Affiliated Tumor Hospital of Guangxi Medical University , NanNing , P.R. China .
authors.forename: Chao
authors.initials: C
authors.lastname: Ou
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , P.R. China .
authors.forename: Zong-Pei
authors.initials: ZP
authors.lastname: Jiang
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , P.R. China .|c Department of Critical Care Medicine , and.
authors.forename: Meng-Ran
authors.initials: MR
authors.lastname: Xiong
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , P.R. China .|d Department of Respiration , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002454:Cell Differentiation / Q000187:drug effects; D015687:Cell Hypoxia / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D024141:Collagen Type IV / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D007684:Kidney Tubules / Q000187:drug effects / Q000293:injuries / Q000378:metabolism / Q000473:pathology*; D060850:LIM-Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D024141:Collagen Type IV; C112149:LIM homeobox transcription factor 1 beta; D060850:LIM-Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D053773:Transforming Growth Factor beta1; D014212:Tretinoin
keywords: All-trans retinoic acid; LMX1B; extracellular matrix; renal tubular epithelial cell; transforming growth factor-β1