title: Persistent low expression of hZip1 in mucinous carcinomas of the ovary, colon, stomach and lung.
abstract: BACKGROUND
  Mucinous carcinomas from different organs are morphologically similar and might share similarities at the molecular and biochemical levels that may illuminate their pathogenesis and influence management. The factors involved in the pathogenesis of mucinous carcinomas remain unknown; which is likely one contributor to the current dearth of biomarkers for detection. Because zinc changes are implicated in some cancers e.g., prostate; we assessed the possibility of a similar role in mucinous carcinomas.
  
  
  METHODS
  The goal of the current work is to study the expression of hZip1 by immunohistochemistry in mucinous carcinomas as compared with non-neoplastic epithelia and conventional carcinomas. Tissue microarray slides containing mucinous carcinomas of the ovary (n = 35), colon (n = 51), stomach (n = 32) and lung (n = 21) were used.
  
  
  RESULTS
  hZip1 showed persistent low expression in mucinous compared to ovarian serous carcinomas and normal tissue (P < 0.05), colonic adenocarcinoma and normal mucosa (P < 0.001), and gastric adenocarcinoma and normal epithelium (P < 0.05). hZip1 also showed low expression in pulmonary mucinous carcinomas.
  
  
  CONCLUSIONS
  hZip1 is consistently decreased in mucinous carcinomas from a variety of organs. Despite the fact that these preliminary findings are unlikely to be of much diagnostic significance, these findings suggest that hZip1 plays a fundamental role in the carcinogenesis of mucinous tumors.
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, MCN, C-2310A, Nashville, TN, 37232-2561, USA. mokhtar.desouki@vanderbilt.edu.
authors.forename: Mohamed Mokhtar
authors.initials: MM
authors.lastname: Desouki
authors.affiliation: Department of Oncology and Diagnostic Sciences and the Greenebaum Cancer Center/Dental School, University of Maryland, Baltimore, MD, 21201, USA. RFranklin@umaryland.edu.
authors.forename: Renty B
authors.initials: RB
authors.lastname: Franklin
authors.affiliation: Department of Oncology and Diagnostic Sciences and the Greenebaum Cancer Center/Dental School, University of Maryland, Baltimore, MD, 21201, USA. LCostello@umaryland.edu.
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Costello
authors.affiliation: Department of Pathology, San Diego Medical Center, University of California San Diego, San Diego, CA, 92103, USA. ofadare@mail.ucsd.edu.
authors.forename: Oluwole
authors.initials: O
authors.lastname: Fadare
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D027682:Cation Transport Proteins / Q000096:biosynthesis* / Q000235:genetics; D003106:Colon / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D010053:Ovary / Q000378:metabolism / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D027682:Cation Transport Proteins; C403517:SLC39A1 protein, human