title: Effect of Octacalcium-Phosphate-Modified Micro/Nanostructured Titania Surfaces on Osteoblast Response.
abstract: Surface structures and properties of titanium implants play a vital role in successful bone replacement. To mimic the natural bone structure, some strategies have recently focused on the preparation of multiscaled morphology on medical titanium and shown some promising results; however, relatively few efforts have been made for further enhancing the biocompatibility of such a hierarchical hybrid structure without compromising the superior bioactivity of the starting micro/nano roughness. In this study, a thin ribbonlike octacalcium phosphate (OCP) coating was electrodeposited on a hierarchically structured titania surface, maintaining its micro/nanospongelike morphology. It is indicated that the micro/nanostructured surface with deposited OCP showed an improved biomineralization ability, in comparison to that without OCP modification, when immersed in simulated body fluid (SBF). Further evaluations of cellular activities demonstrated that the introduction of OCP to the micro/nano spongelike-structured surface remarkably enhanced MC3T3-E1 cell proliferation, alkaline phosphatase activity, and extracellular matrix mineralization compared to that of cells on the micro/nanospongelike titania surface during 14 days of culturing. Meanwhile, the OCP-deposited micro/nanostructured surface displayed much a smaller passive current density and lower current response to the applied potential, resulting in the improvement of corrosion resistance. All of the evaluations suggested that the modification of the OCP coating on the prepared micro/nanospongelike titania is of superior chemical stability, biomineralization, and osteoblast activities, which indicates a favorable implant microenvironment for osseointegration in vivo.
authors.forename: Pinliang
authors.initials: P
authors.lastname: Jiang
authors.forename: Jianhe
authors.initials: J
authors.lastname: Liang
authors.forename: Ran
authors.initials: R
authors.lastname: Song
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Ren
authors.affiliation: §Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Lihai
authors.initials: L
authors.lastname: Zhang
authors.affiliation: §Department of Orthopaedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Peifu
authors.initials: P
authors.lastname: Tang
authors.forename: Changjian
authors.initials: C
authors.lastname: Lin
mesh_terms: D000818:Animals; D001031:Apatites / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D003343:Corrosion; D051379:Mice; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry / Q000633:toxicity*; D010006:Osteoblasts / Q000187:drug effects*; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D002130:Calcium Phosphates; C009495:titanium dioxide; C020243:calcium phosphate; D014025:Titanium
keywords: apatite; cellular activities; corrosion resistance; octacalcium phosphate; titania