title: Regulation of dendrite morphogenesis by extrinsic cues.
abstract: Dendrites play a central role in the integration and flow of information in the nervous system. The morphogenesis and maturation of dendrites is hence an essential step in the establishment of neuronal connectivity. Recent studies have uncovered crucial functions for extrinsic cues in the development of dendrites. We review the contribution of secreted polypeptide growth factors, contact-mediated proteins, and neuronal activity in distinct phases of dendrite development. We also highlight how extrinsic cues influence local and global intracellular mechanisms of dendrite morphogenesis. Finally, we discuss how these studies have advanced our understanding of neuronal connectivity and have shed light on the pathogenesis of neurodevelopmental disorders.
authors.affiliation: Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Pamela
authors.initials: P
authors.lastname: Valnegri
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Sidharth V
authors.initials: SV
authors.lastname: Puram
authors.affiliation: Department of Anatomy and Neurobiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bonni@wustl.edu.
authors.forename: Azad
authors.initials: A
authors.lastname: Bonni
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D003463:Cues; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D009414:Nerve Growth Factors / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology*; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents
keywords: calcium signaling; contact-mediated regulators; dendrite morphogenesis; neuronal activity; secreted polypeptide growth factors