title: [Imported histoplasmosis].
abstract: Infections with Histoplasma capsulatum are rare in Germany, and mostly imported from endemic areas. Infections can present as localized or disseminated diseases in immunocompromised as well as immunocompetent hosts. A travel history may be a major clue for diagnosing histoplasmosis. Diagnostic tools include histology, cultural and molecular detection as well as serology. Here we present four cases of patients diagnosed and treated in Freiburg between 2004 and 2013 that demonstrate the broad range of clinical manifestations of histoplasmosis: an immunocompetent patient with chronic basal meningitis; a patient with HIV infection and fatal disseminated disease; a patient with pulmonary and cutaneous disease and mediastinal and cervical lymphadenopathy; and an immunosuppressed patient with disseminated involvement of lung, bone marrow and adrenal glands.
authors.affiliation: Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.
authors.forename: Katarina
authors.initials: K
authors.lastname: Stete
authors.affiliation: Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.
authors.forename: Winfried V
authors.initials: WV
authors.lastname: Kern
authors.affiliation: Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.
authors.forename: Siegbert
authors.initials: S
authors.lastname: Rieg
authors.affiliation: Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Freiburg.
authors.forename: Annerose
authors.initials: A
authors.lastname: Serr
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinikum Köln.
authors.forename: Christian
authors.initials: C
authors.lastname: Maurer
authors.affiliation: Konsiliarlabor für importierte Systemmykosen, Robert Koch-Institut Berlin.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Tintelnot
authors.affiliation: Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.
authors.forename: Dirk
authors.initials: D
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D006660:Histoplasmosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D016921:Meningitis, Fungal / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents