title: Preoperative transaortic forward flow: Prediction of surgical outcomes in patients with DCM and mitral regurgitation.
abstract: BACKGROUND
  In patients with dilated cardiomyopathy and mitral regurgitation, preoperative prognostic factors are very important.
  
  
  METHODS
  We hypothesized that preoperative transaortic forward flow might be related to postoperative survival, despite mitral regurgitant volume. We retrospectively evaluated surgical outcomes and echocardiographic parameters, including forward flow through the aortic valve.
  
  
  RESULTS
  Seventy-nine patients (54 males, 25 females; mean age 59 ± 12 years) with dilated cardiomyopathy and mitral regurgitation were divided into two groups according to postoperative outcome: 19 patients in group A suffered cardiac death, 60 in group B survived or died of another cause. In group A, death occurred after 227 ± 116 days, group B patients survived (except one who died of infection) for 505 ± 446 days; p < 0.01. Preoperatively, there was no significant difference in ejection fraction, end-diastolic and end-systolic volume index, mitral regurgitant volume, effective regurgitant orifice area, or right ventricular systolic pressure. Preoperative transaortic forward flow was significantly lower in group A vs. group B (1.57 ± 0.33 vs. 1.81 ± 0.46 L m(-2); p 0.04). In group B, transaortic forward flow was increased significantly before discharge (1.81 ± 0.51 vs. 2.43 ± 0.62 L m(-2); p < 0.01). Ejection fraction was significantly alleviated before discharge (28% ± 9% vs. 23% ± 8%; p < 0.01) and recovered to the preoperative value without repeat dilation of the left ventricle in late follow-up.
  
  
  CONCLUSIONS
  Preoperative transaortic forward flow may be a predictor of survival in patients with dilated cardiomyopathy and mitral regurgitation, irrespective of mitral regurgitant volume.
authors.affiliation: Department of Cardiovascular Surgery, Hayama Heart Center, Kanagawa, Japan hirota@hayamaheart.gr.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Hirota
authors.affiliation: Department of Cardiovascular Surgery, Hayama Heart Center, Kanagawa, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Cardiovascular Surgery, Hayama Heart Center, Kanagawa, Japan.
authors.forename: Joji
authors.initials: J
authors.lastname: Hoshino
authors.affiliation: Department of Cardiovascular Surgery, Hayama Heart Center, Kanagawa, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Cardiovascular Surgery, Hayama Heart Center, Kanagawa, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isomura
mesh_terms: D000368:Aged; D062186:Arterial Pressure; D006348:Cardiac Surgical Procedures / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D004452:Echocardiography / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D020257:Ventricular Remodeling
keywords: Cardiomyopathy; Dilated; Heart failure; Hemodynamics; Mitral valve insufficiency; Prognosis; Ventricular remodeling