title: Assoication of XRCC1 gene polymorphisms with risk of non-small cell lung cancer.
abstract: DNA repair genes is a key factor for cancer susceptibility, and we conducted a case-control study to investigate the association of XRCC1 codons 194 (Arg to Trp), 280 (Arg to His) and 399 (Arg to Gln) with risk of NSCLC. 210 NSCLC patients and 210 health control subjects were randomly selected from Huaihe Hospital between January 2012 and June 2014. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was taken to assess the genotyping of XRCC1 Arg194Trp, Arg280His and Arg399Gln. By multivariate logistic regression analysis, we found individuals carrying with Trp/Trp and Arg/Trp + Trp/Trp genotypes were associated with a significantly increased risk of NSCLC compared with Arg/Arg genotype, and the OR (95% CI) were 3.15 (1.32-8.09) and 1.52 (1.02-2.28), respectively. The potential association of Arg/Trp+ Trp/Trp genotype of XRCC1 Arg194Trp with the risk of NSCLC is more evidence in smokers, and the OR (95% CI) was 1.78 (1.01-3.24). In conclusion, we found that XRCC1 Arg194Trp polymorphism may be associated with NSCLC risk, especially in smokers.
authors.affiliation: Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University Guangzhou 510515, China ; Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050, China.
authors.forename: Shirong
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Oncology, Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050, China.
authors.forename: Caixia
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Digestion, Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Cao
authors.affiliation: Department of Thoracic Surgery, the Affiliated People's Hospital of Inner Mongolia Medical College Hohhot 010050, China.
authors.lastname: Hanbateer
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Jiamusi University Jiamusi 510515, China.
authors.forename: Jiafeng
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University Guangzhou 510515, China.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiothoracic Surgery, Nanfang Hospital, Southern Medical University Guangzhou 510515, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human
keywords: XRCC1; non-small cell lung cancer; polymorphism