title: No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population.
abstract: BACKGROUND
  The aim of our study was to investigate the possible relationship between polymorphisms in PTEN (the phosphatase and tensin homolog located on chromosome ten in humans) and POI (primary ovarian insufficiency) in Chinese women.
  
  
  METHODS
  Seven tag SNPs (single nucleotide polymorphisms) - rs1234219, rs1903858, rs2299939, rs35352882, rs17107001, rs2299941 and rs12572106 - were chosen from the CHB (Han Chinese people in Beijing, China) HapMap database. MALDI-TOF-MS (matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry) was used to detect the genotype distribution of the seven SNPs among 148 POI patients and 230 controls.
  
  
  RESULTS
  No statistically significant difference was found in an association analysis of the seven SNPs in the allele frequencies, genotype frequencies, or haplotype distributions.
  
  
  CONCLUSIONS
  In summary, this study explored the relationship between polymorphisms in PTEN and POI in a Han Chinese population and suggests that polymorphisms in PTEN may not be associated with a risk of POI.
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. tottizou@126.com.|Institute of Reproductive Genetics, Anhui Medical University, Hefei, China. tottizou@126.com.|Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China. tottizou@126.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Zou
authors.affiliation: Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China. wbbahu@163.com.|Peking Union Medical College, Beijing, China. wbbahu@163.com.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China. mars_sport@msn.com.|Peking Union Medical College, Beijing, China. mars_sport@msn.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. zzg_100@163.com.|Institute of Reproductive Genetics, Anhui Medical University, Hefei, China. zzg_100@163.com.|Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China. zzg_100@163.com.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. xxf0550@yahoo.com.cn.|Institute of Reproductive Genetics, Anhui Medical University, Hefei, China. xxf0550@yahoo.com.cn.|Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China. xxf0550@yahoo.com.cn.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. cbl0118@126.com.|Institute of Reproductive Genetics, Anhui Medical University, Hefei, China. cbl0118@126.com.|Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China. cbl0118@126.com.
authors.forename: Beili
authors.initials: B
authors.lastname: Chen
authors.affiliation: Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081, China. NICGR@263.net.|Peking Union Medical College, Beijing, China. NICGR@263.net.|World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China. NICGR@263.net.
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. caoyunxia_profr@126.com.|Institute of Reproductive Genetics, Anhui Medical University, Hefei, China. caoyunxia_profr@126.com.|Anhui Provincial Engineering Technology Research Center for Biopreservation and Artificial Organs, Hefei, China. caoyunxia_profr@126.com.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D055815:Young Adult
chemical_list: D051059:PTEN Phosphohydrolase