title: Upregulation of miR-107 Inhibits Glioma Angiogenesis and VEGF Expression.
abstract: MicroRNAs can function as oncogenes or tumor suppressors in glioma. Previously, we showed that miR-107 inhibits glioma cell proliferation, migration, and invasion. Since tumor growth and invasion are closely related to angiogenesis, we further examined the role of miR-107 in glioma angiogenesis. In a co-culture of glioma cells and human brain microvascular endothelial cells (HBMVEC), overexpression of miR-107 in glioma cells led to the inhibition of HBMVEC proliferation, migration, and tube formation ability. ELISA, RT-PCR, and western blot assays revealed that upregulation of miR-107 in glioma cells inhibits VEGF expression. Our findings collectively support the critical involvement of miR-107 in glioma cell angiogenesis and highlight its potential as a therapeutic target for glioma.
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.|Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China.
authors.forename: Zong-yang
authors.initials: ZY
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China.
authors.forename: Sui-yi
authors.initials: SY
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China.
authors.forename: Xie-jun
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Medicine, Shandong University, Jinan, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Luo
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. liweiping60@139.com.|Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, 3002# Sungang Road, Shenzhen, 518035, China. liweiping60@139.com.
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000098:blood supply* / Q000235:genetics* / Q000473:pathology; D057809:HEK293 Cells; D006801:Humans; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D055806:Microvessels / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics*; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C549045:MIRN107 microRNA, human; D035683:MicroRNAs; D042461:Vascular Endothelial Growth Factor A
keywords: Angiogenesis; Glioma; HBMVEC; VEGF; miR-107