title: Mitochondrial Ion Channels in Cancer Transformation.
abstract: Cancer transformation involves reprograming of mitochondrial function to avert cell death mechanisms, monopolize energy metabolism, accelerate mitotic proliferation, and promote metastasis. Mitochondrial ion channels have emerged as promising therapeutic targets because of their connection to metabolic and apoptotic functions. This mini review discusses how mitochondrial channels may be associated with cancer transformation and expands on the possible involvement of mitochondrial protein import complexes in pathophysiological process.
authors.affiliation: Department of Natural Sciences, Baruch College, City University of New York , New York, NY , USA ; City University of New York Graduate Center , New York, NY , USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Madamba
authors.affiliation: Department of Natural Sciences, Baruch College, City University of New York , New York, NY , USA.
authors.forename: Kevin N
authors.initials: KN
authors.lastname: Damri
authors.affiliation: Department of Chemistry, College of Science and Mathematics, California State University Fresno , Fresno, CA , USA.
authors.forename: Laurent M
authors.initials: LM
authors.lastname: Dejean
authors.affiliation: Department of Natural Sciences, Baruch College, City University of New York , New York, NY , USA ; City University of New York Graduate Center , New York, NY , USA ; Department of Basic Sciences, New York University College of Dentistry , New York, NY , USA.
authors.forename: Pablo M
authors.initials: PM
authors.lastname: Peixoto
keywords: MAC; PTP; TIM; TOM; VDAC; cancer cell transformation