title: A Heritable Predisposition to Osteoarthritis of the Hip.
abstract: Using THA as a proxy for underlying osteoarthritis, we describe population-based familial clustering of osteoarthritis of the hip. The GIF test for excess relatedness on 1049 patients that underwent THA (and do not have a diagnostic code for other conditions leading to THA) showed excess relatedness (P<0.001). Even when close relationships were ignored (closer than third-degree relationships), excess relatedness was observed (P=0.020). Relative risk was elevated in first-degree (RR 2.59; 95% CI 1.84-3.53, P=2.0e(-7)), second-degree (RR 1.66; 95% CI 1.11-2.39; P=0.0075) and third-degree relatives (RR 1.46; 95% CI 1.17-1.81; P=5.7e(-4)). Excess relatedness of individuals who had undergone THA for osteoarthritis and elevated risks to both near and distant relatives were observed.
authors.affiliation: Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Pelt
authors.affiliation: Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Erickson
authors.affiliation: Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Peters
authors.affiliation: Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Mike B
authors.initials: MB
authors.lastname: Anderson
authors.affiliation: Division of Genetic Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah.
authors.forename: Lisa
authors.initials: L
authors.lastname: Cannon-Albright
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000706:statistics & numerical data*; D016000:Cluster Analysis; D016208:Databases, Factual; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D015207:Osteoarthritis, Hip / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D012306:Risk; D014589:Utah
keywords: UPDB; familial clustering; heritable predisposition; osteoarthritis; total hip arthroplasty