title: A Pilot Study on the Efficacy of Continuous Positive Airway Pressure on the Manifestations of Ménière's Disease in Patients with Concomitant Obstructive Sleep Apnea Syndrome.
abstract: OBJECTIVE
  To evaluate the effect of continuous positive airway pressure (CPAP) therapy on Ménière's disease patients with concomitant obstructive sleep apnea syndrome (OSAS), since recent reports suggest OSAS may cause dysfunction of the vestibular system.
  
  
  METHODS
  Prospective study using CPAP administered to patients diagnosed with "Definite Ménière's disease" according to the guidelines of the American Academy of Otolaryngology--Head and Neck Surgery and combined with OSAS.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Twenty consecutive patients, 14 male and 6 female with active, unilateral, cochleovestibular Ménière's disease refractory to medical management who also had concurrent OSAS as defined by International Classification of Sleep Disorders, Second Edition were selected to undergo solitary CPAP therapy. Audiometric testing, caloric testing, and DHI survey were conducted before and after CPAP therapy and compared to assess effectiveness of CPAP therapy as utilized for treatment of Ménière's disease.
  
  
  RESULTS
  Although caloric testing did not show significant difference, audiometric testing and results of dizziness handicap inventory were significantly improved (p < 0.05) after CPAP therapy only, without standard treatment for Ménière's disease.
  
  
  CONCLUSIONS
  Recent reports have suggested that OSAS may cause dysfunction of the vestibular system. We investigated whether standard therapy for OSAS would be of benefit in the management of vertigo and hearing loss in Ménière's disease patients. Our study cohort demonstrated significant improvement in both DHI and audiometric testing following solitary CPAP therapy for OSAS. Solitary CPAP therapy may become a new effective treatment strategy for Ménière's disease patients with OSAS, not just only for control of dizziness and vertigo but also for potential benefit of hearing.
authors.affiliation: Good Sleep Center, Nagoya City University Hospital, Nagoya, Japan.|Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Meiho
authors.initials: M
authors.lastname: Nakayama
authors.affiliation: Good Sleep Center, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Masuda
authors.affiliation: Good Sleep Center, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Kayoko Bhardwaj
authors.initials: KB
authors.lastname: Ando
authors.affiliation: Good Sleep Center, Nagoya City University Hospital, Nagoya, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Arima
authors.affiliation: Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Kabaya
authors.affiliation: Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Inagaki
authors.affiliation: Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nakamura
authors.affiliation: Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology, University of California, Davis, CA.
authors.forename: Hilary
authors.initials: H
authors.lastname: Brodie
authors.affiliation: Department of Otolaryngology, University of California, Davis, CA.
authors.forename: Rodney C
authors.initials: RC
authors.lastname: Diaz
authors.affiliation: Department of Otolaryngology, Nagoya City University, Nagoya, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Murakami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications*; D008875:Middle Aged; D010865:Pilot Projects; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome
keywords: CPAP; DHI; Ménière's disease; OSAS; audiogram; caloric test; sleep