title: Anticoagulation strategies for venous thromboembolism: moving towards a personalised approach.
abstract: Four non-vitamin K antagonist oral anticoagulants (NOACs) have now been evaluated in clinical trials, providing new therapeutic options for the treatment of venous thromboembolism (VTE). Recent position statements call for a move towards tailored recommendations for the treatment of VTE, to better define in whom and under what conditions a particular anticoagulant may improve clinical outcomes. Here we review the phase III data on NOAC trials for the treatment of VTE, assessing the favourability of agents for particular patient subgroups and aetiologies. Where the data permit, individualised risks of recurrent VTE events and bleeding are presented.
authors.affiliation: Stephen Black, Department of Vascular Surgery, Guy's and St Thomas' Hospital, 1st Floor North Wing, 1 Westminster Bridge Road, London SE1 7EH, UK, Tel.: +44 207 188 2574, Fax: +44 207 188 1094, E-mail: Stephen.black@gstt.nhs.uk.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Black
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Cohen
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects*; D017326:Clinical Trials, Phase III as Topic; D004334:Drug Administration Schedule; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D018579:Patient Selection; D057285:Precision Medicine; D011655:Pulmonary Embolism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D020246:Venous Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000925:Anticoagulants
keywords: Deep-vein thrombosis; clinical trials; oral anticoagulants; pulmonary embolism; venous thrombosis