title: Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy.
abstract: Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life. Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues. Recent research shows that Wnt signaling is also associated with the regulation of cancer stem cells (CSCs) through a similar mechanism to that observed in normal adult stem cells. Thus, the Wnt/β-catenin signaling pathway has been intensively studied and characterized. For this review, we will focus on the regulation of the Wnt/β-catenin signaling pathway in skin cancer. With the important role in stemness and skin CSC proliferation, the Wnt/β-catenin signaling pathway and its elements have the potential to be targets for skin cancer therapy.
authors.affiliation: Institute of Tropical Medicine, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Tropical Medicine, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ji
authors.affiliation: Department of Hematology, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
authors.forename: Jieping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA.
authors.forename: Wengeng
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Institute of Tropical Medicine, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
authors.forename: Zhijia
authors.initials: Z
authors.lastname: Ye
mesh_terms: D063646:Carcinogenesis; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D051153:Wnt Proteins / Q000235:genetics*; D060449:Wnt Signaling Pathway / Q000235:genetics*
chemical_list: D051153:Wnt Proteins