title: The relationship between weight, height and body mass index with hemodynamic parameters is not same in patients with and without chronic kidney disease.
abstract: BACKGROUND
  Although anthropometric measurements are related with clinical outcomes; these relationships are not universal and differ in some disease states such as in chronic kidney disease (CKD). The current study was aimed to analyze the relationship between height, weight and BMI with hemodynamic and arterial stiffness parameters both in normal and CKD patients separately.
  
  
  METHODS
  This cross-sectional study included 381 patients with (N 226) and without CKD (N 155) with hypertension. Routine laboratory and 24-h urine collection were performed. Augmentation index (Aix) which is the ratio of augmentation pressure to pulse pressure was calculated from the blood pressure waveform after adjusted heart rate at 75 [Aix@75 (%)]. Pulse wave velocity (PWV) is a simple measure of the time taken by the pressure wave to travel over a specific distance. Both [Aix@75 (%)] and PWV which are measures of arterial stiffness were measured by validated oscillometric methods using mobil-O-Graph device.
  
  
  RESULTS
  In patients without CKD, height is inversely correlated with [Aix@75 (%)]. Additionally, weight and BMI were positively associated with PWV in multivariate analysis. However, in patients with CKD, weight and BMI were inversely and independently related with PWV. In CKD patients, as weight and BMI increased stiffness parameters such as Aix@75 (%) and PWV decreased. While BMI and weight are positively associated with arterial stiffness in normal patients, this association is negative in patients with CKD.
  
  
  CONCLUSIONS
  In conclusion, height, weight and BMI relationship with hemodynamic and arterial stiffness parameters differs in patients with and without CKD.
authors.affiliation: Department of Nephrology, Ferhuniye Mah. Hastane Cad. Konya Numune State Hospital, 42690, Konya, Turkey. afsarbrs@yahoo.com.
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.affiliation: Department of Nephrology, Selcuklu Faculty of Medicine, Selcuk University, Konya, Turkey.
authors.forename: Rengin
authors.initials: R
authors.lastname: Elsurer
authors.affiliation: Department of Nephrology, Ataturk Training and Educational Hospital, Izmir Katip Celebi University, Çiğli, Turkey. Izmirsoypacaci@yahoo.com.
authors.forename: Zeki
authors.initials: Z
authors.lastname: Soypacaci
authors.affiliation: Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015999:Multivariate Analysis; D063177:Pulse Wave Analysis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D059289:Vascular Stiffness
chemical_list: D000959:Antihypertensive Agents
keywords: Body mass index; Chronic kidney disease; Height; Hemodynamic; Hypertension; Stiffness; Weight