title: Investigation of Subcortical Gray Matter in Patients with Non-lesional Neocortical Focal Epilepsy.
abstract: OBJECTIVE
  To investigate whether there is any change in the subcortical gray matter of patients with neocortical focal epilepsy without visible magnetic resonance imaging (MRI) abnormalities.
  
  
  METHODS
  MRI morphometric parameter data from 24 patients and 29 neurologically normal controls were analyzed. All of the MRI scans were reported to have no any anomaly. Differences were evaluated by vertex-wise shape analysis.
  
  
  RESULTS
  A shape analysis showed significant surface reductions at the anterior-ventral and the posteriordorsal aspects of the bilateral thalami, the global left caudate nucleus, part of the bilateral dorsal putamen and the left hippocampus.
  
  
  CONCLUSIONS
  Patients with focal seizures and secondary generalization had smaller volumes and microstructural anomalies in subcortical gray matter regions.
authors.affiliation: Department of Neurology, Chung Shan Medical University and Chung Shan Medical University Hospital.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Fan
authors.affiliation: Department of Electrical Engineering, National Central University.
authors.forename: Syu-Jyun
authors.initials: SJ
authors.lastname: Peng
authors.affiliation: Department of Neurosurgery, Hualien Tzu Chi General Hospital.
authors.forename: Tomor
authors.initials: T
authors.lastname: Harnod
authors.affiliation: Biomedical Electronics Translational Research Center, National Chiao Tung University.
authors.forename: Chien-Chun
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Department of Neurology, Chung Shan Medical University and Chung Shan Medical University Hospital.
authors.forename: Yue-Loong
authors.initials: YL
authors.lastname: Hsin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004828:Epilepsies, Partial / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged