title: Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis.
abstract: BACKGROUND
  Patients with cystic fibrosis (CF) may be at risk for micronutrient depletion, particularly during periods of illness and infection. The purpose of this study was to investigate serum micronutrient status over time in adults with CF initially hospitalized with a pulmonary exacerbation.
  
  
  METHODS
  This was an ancillary study of a multicenter trial investigating the role of high-dose vitamin D supplementation in 24 adults with CF (mean age, 29.6 ± 7.3 years). We measured serum concentrations of copper (Cu), iron (Fe), calcium (Ca), magnesium (Mg), potassium (K), and sulfur (S) in subjects at the beginning of a pulmonary exacerbation and again at 3 months.
  
  
  RESULTS
  Serum concentrations of Cu, Fe, and Ca were significantly lower at baseline compared with 3 months following the pulmonary exacerbation (Cu: baseline, 1.5 ± 0.6 vs 3 months, 1.6 ± 0.6 µg/mL, P = .027; Fe: 0.8 ± 0.3 vs 1.3 ± 1.1 µg/mL, P = .026; Ca: 9.7 ± 0.8 vs 10.8 ± 2.0 mg/dL, P = .024). Serum concentrations of K, Mg, and S did not change over time (K: baseline, 4.9 ± 0.3 vs 3 months, 5.1 ± 0.5 mEq/L; Mg: 1.8 ± 0.2 vs 2.0 ± 0.3 mg/dL; S: 1288.6 ± 343 vs 1309.9 ± 290 µg/mL; P > .05 for all).
  
  
  CONCLUSIONS
  Serum concentrations of Cu, Fe, and Ca increased significantly several months following recovery from acute pulmonary exacerbation in adults with CF. This may reflect decreased inflammation, improved food intake, and/or increased absorption following recovery.
authors.affiliation: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia.
authors.forename: Moon Jeong
authors.initials: MJ
authors.lastname: Lee
authors.affiliation: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Alvarez
authors.affiliation: Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, Georgia.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Smith
authors.affiliation: Nutrition & Metabolism Center, Children's Hospital Oakland Research Institute, Oakland, California.
authors.forename: David W
authors.initials: DW
authors.lastname: Killilea
authors.affiliation: Department of Pediatrics, Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, Ohio.
authors.forename: James F
authors.initials: JF
authors.lastname: Chmiel
authors.affiliation: Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio.
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Joseph
authors.affiliation: College of Nursing, University of Iowa, Iowa City, Iowa.
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Grossmann
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Amit
authors.initials: A
authors.lastname: Gaggar
authors.affiliation: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ziegler
authors.affiliation: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, and the Atlanta VA Medical Center, Atlanta, Georgia Center for Clinical and Molecular Nutrition, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, Georgia vin.tangpricha@emory.edu.
authors.forename: Vin
authors.initials: V
authors.lastname: Tangpricha
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000097:blood* / Q000503:physiopathology*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D018977:Micronutrients / Q000097:blood*; D015596:Nutrition Assessment
chemical_list: D018977:Micronutrients
keywords: calcium; copper; cystic fibrosis; iron; lung; magnesium; micronutrients; potassium; sulfur