title: [The expression of E-cadherin, vimentin, β-catenin, transforming growth factor-β1 in oral squamous cell carcinomas].
abstract: OBJECTIVE
  To investigate the expression of E-cadherin, vimentin, β-catenin and transforming growth factor-β1 (TGF-β1) in oral squamous cell carcinomas (OSCC).
  
  
  METHODS
  Eighty-nine cases of OSCC and 20 cases of normal oral mucosa were collected. Then the 89 cases of OSCC were classified as grade I, II, III. The semiquantitative method was used to calculated the positive intensity and positive rate. The relationship between the OSCC differentiation and the four biomarkers was analyzed.
  
  
  RESULTS
  The median of E-cadherin was 9.00 in the normal tissue, 9.00, 6.00 and 6.00 in OSCC I, II and III, respectively. There was significant difference between the normal group and OSCC group (Z=-4.211, P=0.000). The median of vimentin was 0.00 in the normal tissue, 0.00, 0.00 and 4.00 in OSCC I, II and III, respectively. There was significant difference between the normal group and OSCC group (Z=-3.675, P=0.000). The median of β-catenin was 9.00 in the normal tissue, 3.00, 4.00 and 3.00 in OSCC I, II and III, respectively. There was significant difference between the normal group and OSCC group (Z=-6.300, respectively. There was significant difference between the normal group and OSCC group (Z=-3.329, P=0.000). E-cadherin expression was positively correlated to β-catenin expression (r=0.327, P=0.002), negtively correlated to vimentin expression (r=-0.386, P=0.001) and positively correlated to TGF-β1 expression (r=-0.304, P=0.004). Vimentin expression was positively correlated to TGF-β1 expression (r=0.401, P=0.000).
  
  
  CONCLUSIONS
  E-cadherin and β-catenin in OSCC had a down-regulated expression, while the vimentin has an up-regulated expression.
authors.affiliation: Department of Stomatology, School of Medicine, Jinan University, Guangzhou 510632, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Lu
authors.forename: Cao
authors.initials: C
authors.lastname: Yin
authors.forename: Minghan
authors.initials: M
authors.lastname: Xia
authors.affiliation: Email: xsming@sina.com.
authors.forename: Siming
authors.initials: S
authors.lastname: Xie
mesh_terms: D015820:Cadherins / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D009061:Mouth Mucosa / Q000166:cytology / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D015291:Transforming Growth Factors / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D015820:Cadherins; D009363:Neoplasm Proteins; D053773:Transforming Growth Factor beta1; D014746:Vimentin; D051176:beta Catenin; D015291:Transforming Growth Factors