title: Hydroxylated Mesoporous Nanosilica Coated by Polyethylenimine Coupled with Gadolinium and Folic Acid: A Tumor-Targeted T(1) Magnetic Resonance Contrast Agent and Drug Delivery System.
abstract: A pH-responsive nanoplatform, hydroxylated mesoporous nanosilica (HMNS) coated by polyethylenimine (PEI) coupled with gadolinium and folic acid (FA) (Gd-FA-Si), was designed to deliver anticancer drug targeting and to promote contrast effect for tumor cells using magnetic resonance (MR) spectrometer. Doxorubicin (DOX) was chosen as the anticancer drug and loaded into nanopores of HMNS, then its release in simulated body fluid could be controlled through adjusting the pH. This nanoplatform could significantly enhance the MR contrast effect, and the highest theoretical relaxivity per nanoplatform could even be approximately 1.28 × 10(6) mm(-1)s(-1) because of the high Gd payload (2.61 × 10(5) per nanoplatform). The entire system possessed a high targeting performance to Hela and MDA-MB-231 cells because the FA located in the system could specifically bind to the folate-receptor sites on the surface of cell. Compared with free DOX, the nanoplatform presented a higher cell inhibition effect on the basis of cell assay. Therefore, this nanoplatform could be potentially applied as a tumor-targeted T1 MR contrast agent and pH-sensitive drug carrier system.
authors.affiliation: §Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei, Anhui 230031, People's Republic of China.|⊥University of Science and Technology of China, Hefei 230026, People's Republic of China.
authors.forename: Guilong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: #School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Junlan
authors.initials: J
authors.lastname: Gao
authors.forename: Junchao
authors.initials: J
authors.lastname: Qian
authors.affiliation: #School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Lele
authors.initials: L
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Zheng
authors.forename: Kai
authors.initials: K
authors.lastname: Zhong
authors.affiliation: §Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei, Anhui 230031, People's Republic of China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Cai
authors.affiliation: #School of Life Sciences, Anhui Agricultural University, Hefei 230036, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: §Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences and Anhui Province, Hefei, Anhui 230031, People's Republic of China.
authors.forename: Zhengyan
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011094:Polyethyleneimine / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D012822:Silicon Dioxide; D004317:Doxorubicin; D011094:Polyethyleneimine; D005492:Folic Acid; D019786:Gadolinium DTPA
keywords: Gd-DTPA and folic acid; MR contrast agent; hydroxylated mesoporous nanosilica; polyethylenimine; targeted drug delivery system