title: Total and High Molecular Weight Adiponectin Levels and Prediction of Cardiovascular Risk in Diabetic Patients.
abstract: The study aimed at assessing the potential use of lower total and HMW adiponectin levels for predicting cardiovascular risk in patients with type 2 diabetes mellitus (T2DM). Concentrations of total adiponectin or high molecular weight (HMW) adiponectin decrease in association with the development of metabolic dysfunction such as obesity, insulin resistance, or T2DM. Increased adiponectin levels are associated with a lower risk for coronary heart disease. A total of 551 individuals were assessed. The first group comprised metabolically healthy participants (143 females, and 126 males) and the second group were T2DM patients (164 females, and 118 males). Both total adiponectin and HMW adiponectin in diabetic patients were significantly lower when compared with the group of metabolically healthy individuals. There was a weak monotonic correlation between HMW adiponectin levels and triglycerides levels. Binary logistic regression analysis, gender adjusted, showed a higher cardiovascular risk in diabetic persons when both total adiponectin (OR = 1.700) and HMW adiponectin (OR = 2.785) levels were decreased. A decrease in total adiponectin levels as well as a decrease in its HMW adiponectin is associated with a higher cardiovascular risk in individuals with T2DM. This association suggests that adiponectin levels may be potentially used as an epidemiological marker for cardiovascular risk in diabetic patients.
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Horáková
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Kateřina
authors.initials: K
authors.lastname: Azeem
authors.affiliation: Clinic of Internal Medicine, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic.
authors.forename: Radka
authors.initials: R
authors.lastname: Benešová
authors.affiliation: Department of Sports and Exercise Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Pastucha
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Horák
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Lenka
authors.initials: L
authors.lastname: Dumbrovská
authors.affiliation: Clinic of Internal Medicine, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic.
authors.forename: Arnošt
authors.initials: A
authors.lastname: Martínek
authors.affiliation: Department of Clinical Biochemistry and Immunogenetics, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Novotný
authors.affiliation: Department of Clinical Biochemistry, University Hospital Ostrava, 17. Listopadu 1790, 708 52 Ostrava-Poruba, Czech Republic.
authors.forename: Zdeněk
authors.identifier: 0000-0002-7937-3197
authors.initials: Z
authors.lastname: Švagera
authors.affiliation: Department of Respiratory Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic.
authors.forename: Milada
authors.initials: M
authors.lastname: Hobzová
authors.affiliation: Department of Transfusion Medicine, University Hospital Olomouc, I.P. Pavlova 6, 775 15 Olomouc, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Galuszková
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Vladimír
authors.initials: V
authors.lastname: Janout
authors.affiliation: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Sandra
authors.initials: S
authors.lastname: Doněvská
authors.affiliation: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Vrbková
authors.affiliation: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 775 15 Olomouc, Czech Republic.
authors.forename: Helena
authors.initials: H
authors.lastname: Kollárová