title: Periventricular lesions correlate with cortical thinning in multiple sclerosis.
abstract: OBJECTIVE
  It has been suggested recently that cortical pathology in multiple sclerosis (MS) may, at least partly, be caused by factors in cerebrospinal fluid (CSF). We thus hypothesized that MS-related tissue changes in compartments close to the CSF, such as periventricular lesions, might correlate with cortical pathology.
  
  
  METHODS
  We investigated a cohort of 160 patients, comprising 91 with a clinically isolated syndrome (CIS) and 69 with relapsing-remitting MS (RRMS; mean age: CIS: 31.4 ± 9.0; RRMS: 33.0 ± 8.7 years; mean disease duration: CIS: 7.2 ± 15 months; RRMS: 8.0 ± 6.5 years, Expanded Disability Status Scale (median, min-max): CIS: 1, 0-3.5; RRMS: 1.25, 0-4) with 3.0T magnetic resonance imaging. MS lesions were segmented semiautomatically on fluid-attenuated inversion recovery images. To quantify periventricular lesion load (PV-LL), we generated ventricle masks and dilated them by a voxel factor of 3. Lesions within the dilated ventricle margin were classified as periventricular. Cortical thinning was assessed by cortical mean thickness (CMT) and compared to data from 58 healthy controls (HCs; mean age: 29.1 ± 7.4 years).
  
  
  RESULTS
  Compared to HC, CIS and (even more so) RRMS patients demonstrated significantly reduced CMT. Even after controlling for ventricular volume and total lesion load, increased periventricular lesion occupancy (percentage of PV-LL) significantly correlated with decreased CMT in RRMS (r = -0.295; p = 0.015), but not in CIS (r = 0.032; p = 0.768) patients.
  
  
  CONCLUSIONS
  The correlation between increased periventricular lesion burden and decreased CMT indicative of subpial cortical pathology supports the concept that common CSF-mediated factors might play a role in the accumulation of damage to gray and white matter in MS.
authors.affiliation: Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria.
authors.forename: Margit
authors.initials: M
authors.lastname: Jehna
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Lukas
authors.initials: L
authors.lastname: Pirpamer
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Khalil
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Siegrid
authors.initials: S
authors.lastname: Fuchs
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ropele
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Langkammer
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Alexander
authors.initials: A
authors.lastname: Pichler
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Franziska
authors.initials: F
authors.lastname: Stulnig
authors.affiliation: Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria.
authors.forename: Hannes
authors.initials: H
authors.lastname: Deutschmann
authors.affiliation: Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Fazekas
authors.affiliation: Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria.|Department of Neurology, Medical University of Graz, Graz, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Enzinger
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D002552:Cerebral Ventricles / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000378:metabolism; D011446:Prospective Studies; D066127:White Matter / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult