title: pH-Responsive H-Type PMAA2 -b-HTPBN-b-PMAA2 Four-Arm Star Block Copolymer Micelles for PTX Drug Release.
abstract: pH-Responsive H-type poly(methylacrylic acid-block-four hydroxyl terminated poly(butadiene-acrylobitrile)-block-poly(methylacrylic acid (PMAA2 -b-HTPBN-b-PMAA2 ) block copolymers were synthesized via atom transfer radical polymerization and the follow-up hydrolysis, and characterized by (1) H NMR, FT-IR and SEC. The block copolymers could self-assemble into nanoscale spherical core-shell micelle aggregates in aqueous solution, and the physicochemical properties depended on the system composition and pH media, with pH phase transition at 5.7-6.1. The copolymer micelle aggregates exhibited pH-triggered drug release and cytotoxicity, and could potentially be used as drug targeting release carriers.
authors.affiliation: Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China. luoyanl@snnu.edu.cn.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Luo
authors.affiliation: Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors.forename: Mei
authors.initials: M
authors.lastname: Han
authors.affiliation: Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China. fengxu@snnu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors.forename: Ya-Shao
authors.initials: YS
authors.lastname: Chen
authors.affiliation: Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
authors.forename: Yong-Qin
authors.initials: YQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D065546:Drug Liberation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D017239:Paclitaxel / Q000494:pharmacology*; D044367:Phase Transition; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013500:Surface Tension
chemical_list: D008823:Micelles; C000609770:PMAA2-b-HTPBN-b-PMAA2; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D017239:Paclitaxel
keywords: biomaterials; drug delivery systems; micelles; self-assembly; stimuli-sensitive polymers