title: Primary signet ring cell carcinoma of the appendix: A rare case report.
abstract: Primary adenocarcinoma of the appendix is a rare malignancythat constitutes < 0.5% of all gastrointestinalneoplasms. Moreover, primary signet ring cell carcinomaof the appendix is an exceedingly rare entity. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. She was clinically misdiagnosed as torsion of ovarian cyst. She underwent appendicectomy and unilateral salpingo-oophorectomy.Histopathology revealed signet ring cell carcinoma and a right hemicolectomy was done. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX-4). The patient is doing well till today on follow up without progression of disease 10 mo after beginning chemotherapy.
authors.affiliation: Ram V Kulkarni, Sachin B Ingle, Saleha Siddiqui, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India.
authors.forename: Ram V
authors.initials: RV
authors.lastname: Kulkarni
authors.affiliation: Ram V Kulkarni, Sachin B Ingle, Saleha Siddiqui, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India.
authors.forename: Sachin B
authors.initials: SB
authors.lastname: Ingle
authors.affiliation: Ram V Kulkarni, Sachin B Ingle, Saleha Siddiqui, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India.
authors.forename: Saleha
authors.initials: S
authors.lastname: Siddiqui
keywords: Appendix; Ovarian metastasis; Primary; Signet ring cell carcinoma