title: Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses.
abstract: Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Janine
authors.initials: J
authors.lastname: Mühe
authors.affiliation: Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA fwang@research.bwh.harvard.edu.
authors.forename: Fred
authors.initials: F
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology; D001483:Base Sequence; D002520:Cercopithecidae / Q000276:immunology / Q000821:virology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D058507:Host Specificity; D006801:Humans; D018143:Lymphocryptovirus / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: C402641:EBNA-2 protein, Human herpesvirus 4; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins