title: Immune aging, dysmetabolism, and inflammation in neurological diseases.
abstract: As we age, the immune system undergoes a process of senescence accompanied by the increased production of proinflammatory cytokines, a chronic subclinical condition named as "inflammaging". Emerging evidence from human and experimental models suggest that immune senescence also affects the central nervous system and promotes neuronal dysfunction, especially within susceptible neuronal populations. In this review we discuss the potential role of immune aging, inflammation and metabolic derangement in neurological diseases. The discovery of novel therapeutic strategies targeting age-linked inflammation may promote healthy brain aging and the treatment of neurodegenerative as well as neuropsychiatric disorders.
authors.affiliation: Department of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, University of Tübingen Tübingen, Germany.
authors.forename: Michela
authors.initials: M
authors.lastname: Deleidi
authors.affiliation: Department of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, University of Tübingen Tübingen, Germany.
authors.forename: Madeline
authors.initials: M
authors.lastname: Jäggle
authors.affiliation: Department of Internal Medicine II, Center for Medical Research, University of Tübingen Tübingen, Germany.
authors.forename: Graziella
authors.initials: G
authors.lastname: Rubino
keywords: aging; brain-immune interactions; immunosenescence; inflammation; metabolism; neurodegenerative diseases; neuropsychiatric diseases