title: Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans.
abstract: The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.
authors.affiliation: National Glycoengineering Research Center, School of Pharmaceutical Science, Shandong University, Jinan 250012, China. hzcao@sdu.edu.cn fswang@sdu.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Caicai
authors.initials: C
authors.lastname: Meng
authors.forename: Lan
authors.initials: L
authors.lastname: Jin
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Fengshan
authors.initials: F
authors.lastname: Wang
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Cao
mesh_terms: D000446:Aldehyde-Lyases / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry; D049030:Dystroglycans / Q000737:chemistry*; D006031:Glycosylation; D008358:Mannose / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D014166:Transferases / Q000737:chemistry; D014534:UDPglucose 4-Epimerase / Q000737:chemistry
chemical_list: D001426:Bacterial Proteins; D011134:Polysaccharides; D049030:Dystroglycans; D014166:Transferases; D000446:Aldehyde-Lyases; D014534:UDPglucose 4-Epimerase; C020551:galactose epimerase; D008358:Mannose