title: Genetic polymorphisms of interleukin-6 gene and susceptibility to coronary artery disease in Chinese population: Evidence based on 4582 subjects.
abstract: The aim of this study was to explore whether interleukin-6 (IL-6) gene (-174 G/C and -572 C/G) polymorphisms are associated with susceptibility to coronary artery disease (CAD) risk in Chinese population. All the statistical tests were performed using Stata version 11.0. Twelve articles involving 16 studies were included in this meta-analysis, covering a total of 2309 CAD cases and 2273 controls. For IL-6 gene -572 C/G polymorphism, the results showed evidence for significant association between IL-6 gene -572 C/G polymorphism and CAD risk (for G allele vs. C allele: OR=1.48, 95% CI=1.26-1.74, p<0.001; for G/G vs. C/C: OR=2.60, 95% CI=1.54-4.39, p<0.001; for G/G vs. G/C+C/C: OR=2.15, 95% CI=1.35-3.42, p=0.001; for G/G+G/C vs. C/C: OR=1.55, 95% CI=1.29-1.85, p<0.001). However, for IL-6 gene -174 G/C polymorphism, no significant association was found between this variation and CAD risk. In summary, our meta-analysis showed evidence that IL-6 gene -572 C/G polymorphism may be a risk factor for CAD susceptibility. For IL-6 gene -174 G/C polymorphism, no significant association was found between this variation and CAD risk.
authors.affiliation: Department of Respiratory Medicine, Huzhou 3rd Hospital, 2088 Tiaoxi Road, Huzhou, Zhejiang 313000, China. Electronic address: liusl1155@163.com.
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Liu
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China. Electronic address: shuaishuaijita@sohu.com.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
authors.affiliation: Jinsong Sanatorium of Beijing Air Force, Beijing 100021, China.
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Sun
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Hu
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6
keywords: Coronary artery disease; Interleukin-6; Meta-analysis; Single nucleotide polymorphism