title: Analysis of Elastic Tissue in Histological Variants of Pleomorphic Salivary Adenoma seen at the Lagos University Teaching Hospital over a period of 35 Years.
abstract: BACKGROUND
  Pleomorphic salivary adenoma (PSA), is known for its morphologic diversity. While reports of elastic tissue in PSA have been documented, the distribution of this tissue in histological variants of the tumour has not been documented. Perhaps such features may influence biological behaviour of these variants.
  
  
  OBJECTIVE
  To classify PSA in our series into histological variants, and determine possible variation in elastic tissue distribution in them.
  
  
  METHODS
  Eighty eight histologically diagnosed cases of PSA in the oral biopsy archives of the department of Oral Biology and Pathology, Lagos University Teaching Hospital, were retrieved. New H&E sections were cut to reconfirm diagnosis and Verhoeff-Van Gieson's stained sections were cut for demonstration of elastic tissue. Seifert et al.'s (1976) histological classification was applied and elastic tissue presence was determined and quantified for each case. Parameters studied included; sex, age, site, histological subtypes and presence of elastic tissue. Statistical analysis was undertaken using the EPI-INFO version 3.4.
  
  
  RESULTS
  Male:female ratio was 1:1.3. Most cases (63.6%) occurred in the age group of 21-40 years. Generally, palate (42.0%) was the most commonly affected site, while 53.4% of cases were in the minor salivary glands. Seifert et al. classified subtype II lesions were the most frequently observed (39.7%) and elastic tissue was confirmed in 91.0% of cases. No association was noted between proportion of elastic tissue and histological variants.
  
  
  CONCLUSIONS
  Seifert et al subtype II was the most frequently observed and no association was observed between proportion of elastic tissue and the histological variant of PSA.
authors.affiliation: Department of Oral Biology and Oral Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.
authors.forename: O M
authors.initials: OM
authors.lastname: Ogundana
authors.forename: O F
authors.initials: OF
authors.lastname: Ajayi
authors.forename: O
authors.initials: O
authors.lastname: Odukoya
mesh_terms: D008949:Adenoma, Pleomorphic / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002648:Child; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D005544:Forecasting; D006785:Hospitals, University / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D010784:Photomicrography; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000145:classification / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult