title: Cancer Risk in Women Exposed to Diethylstilbestrol in Utero.
abstract: OBJECTIVE
  To evaluate the overall cancer risk, primarily breast cancer, for women exposed to diethylstilbestrol (DES) in utero in France.
  
  
  METHODS
  A cohort of 3 436 prenatally DES exposed women and a comparable cohort of 3256 unexposed women were recruited retrospectively from voluntary responses to questionnaires, and cases were ascertained by medical history at the time of recruitment.
  
  
  RESULTS
  One hundred ninety-five cancers were observed in exposed women (136 breast cancers, and 59 in other sites) and 141 cancers in unexposed women (90 breast cancers, and 51 others). A significant increase of breast cancers was found in exposed women, with a multivariate incidence rate ratio of 2.10 (95% CI 1.60-2.76) when compared with unexposed women. When exposed women were compared with the general population in France, the standardized incidence ratio was 2.33 (95% CI 1.93-2.72).
  
  
  CONCLUSIONS
  Our results suggest a significant increase of breast cancer in prenatally DES exposed women when compared with unexposed women and with the general population. For other cancers, except clear cell carcinoma of the cervix or vagina, there was a global non-significant increase.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Tournaire
authors.affiliation: LPPS Research Unit 4057, Paris Descartes University, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Devouche
authors.affiliation: Oncology Department, Hôpital Saint Louis, Assistance Publique-Hôpitaux de ParisParis Diderot University, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Espié
authors.affiliation: Biostatistics DepartmentInstitut Curie; French National Institute of Health and Medical Research, INSERM Unit 900, Paris, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Asselain
authors.affiliation: President of the Association Réseau DES France, Mont de Marsan, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Levadou
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Cabau
authors.affiliation: Mutualité Française, Paris, France.
authors.forename: Annabel
authors.initials: A
authors.lastname: Dunbavand
authors.affiliation: French National Institute of Health and Medical Research, INSERM Unit 1027, Albi, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Grosclaude
authors.affiliation: Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris Diderot University, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Epelboin
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D015331:Cohort Studies; D016001:Confidence Intervals; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk; D015983:Selection Bias; D057566:Self Report; D011795:Surveys and Questionnaires
chemical_list: D004054:Diethylstilbestrol