title: Assessing the equivalence between etomidate and seizure network dynamics in temporal lobe epilepsy.
abstract: OBJECTIVE
  Etomidate mimics some typical epileptic neurophysiological features, such as the appearance of spikes and high frequency oscillations, when it is administrated to epileptic patients. However, little is known about its influence on the underlying cortical network. An assessment of comparable cortical dynamics between seizures and etomidate would allow for a more detailed study of the network parameters underlying the ictal stage by using etomidate as a proxy. The objective of the present work is to show that temporal lobe seizures produce network changes comparable to the ones elicited by etomidate administration.
  
  
  METHODS
  Scalp and foramen ovale electrodes (FOE) recordings from nine temporal lobe epilepsy patients were analyzed under the complex network perspective. The clustering coefficients, average path lengths, density of links, modularity and spectral entropy were calculated during the pre-ictal and ictal stages and post-etomidate administration. Etomidate administration produced no seizure in any of the analyzed cases.
  
  
  RESULTS
  The density of lines (six of nine patients) and spectral entropy (eight of nine patients) displayed similar behavior to the preictal-ictal transition when etomidate effects altered the epileptic network (FOE+scalp). When considering only the mesial sub-network, changes induced by etomidate perfusion replicated the same type of imbalance observed during the ictal stage in the nine patient's sample and in eight out of nine regarding the preictal stage. Both statistical significance at a level of 1% and size effects, evaluated by using the standardized mean differences, show similar network changes during the preictal-ictal and preictal-etomidate transitions.
  
  
  CONCLUSIONS
  Etomidate perfusion in patients with temporal lobe epilepsy induces network changes comparable to the changes resulting from seizures.
  
  
  CONCLUSIONS
  The finding reported here could improve the study of network dynamics during the ictal phase, not only with electrophysiological methods, but also in other cases, such as functional magnetic resonance imaging.
authors.affiliation: Clinical Neurophysiology, Hospital Universitario de la Princesa, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Vega-Zelaya
authors.affiliation: Clinical Neurophysiology, Hospital Universitario de la Princesa, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Pastor
authors.affiliation: Clinical Neurophysiology, Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Tormo
authors.affiliation: Neurosurgery, Hospital Universitario de la Princesa, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Madrid, Spain.
authors.forename: Rafael G
authors.initials: RG
authors.lastname: de Sola
authors.affiliation: Neurosurgery, Hospital Universitario de la Princesa, Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Madrid, Spain. Electronic address: gjortega.hlpr@salud.madrid.org.
authors.forename: Guillermo J
authors.initials: GJ
authors.lastname: Ortega
mesh_terms: D000200:Action Potentials; D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology; D005045:Etomidate / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D006993:Hypnotics and Sedatives; D005045:Etomidate
keywords: Complex networks; Etomidate; Seizure; Temporal lobe epilepsy