title: Validation of functional imaging as a biomarker for radiation treatment response.
abstract: Major advances in radiotherapy techniques, increasing knowledge of tumour biology and the ability to translate these advances into new therapeutic approaches are important goals towards more individualized cancer treatment. With the development of non-invasive functional and molecular imaging techniques such as positron emission tomography (PET)-CT scanning and MRI, there is now a need to evaluate potential new biomarkers for tumour response prediction, for treatment individualization is not only based on morphological criteria but also on biological tumour characteristics. The goal of individualization of radiotherapy is to improve treatment outcome and potentially reduce chronic treatment toxicity. This review gives an overview of the molecular and functional imaging modalities of tumour hypoxia and tumour cell metabolism, proliferation and perfusion as predictive biomarkers for radiation treatment response in head and neck tumours and in lung tumours. The current status of knowledge on integration of PET/CT/MRI into treatment management and bioimage-guided adaptive radiotherapy are discussed.
authors.affiliation: 1 OncoRay-National Centre for Radiation Research in Oncology, Dresden, Germany.|2 Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden,Helmholtz-Zentrum Dresden-Rossendorf, Germany.|3 German Cancer Consortium (DKTK) Dresden, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Jentsch
authors.affiliation: 1 OncoRay-National Centre for Radiation Research in Oncology, Dresden, Germany.|3 German Cancer Consortium (DKTK) Dresden, Germany.|4 Institute of Radiation Oncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Beuthien-Baumann
authors.affiliation: 1 OncoRay-National Centre for Radiation Research in Oncology, Dresden, Germany.|2 Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden,Helmholtz-Zentrum Dresden-Rossendorf, Germany.|3 German Cancer Consortium (DKTK) Dresden, Germany.|4 Institute of Radiation Oncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
authors.forename: E G C
authors.initials: EG
authors.lastname: Troost
authors.affiliation: 5 Philips Research, Aachen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Shakirin
mesh_terms: D014408:Biomarkers, Tumor; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000503:physiopathology / Q000532:radiotherapy*; D003952:Diagnostic Imaging; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor