title: Real-time TCD-vEEG monitoring for neurovascular coupling in epilepsy.
abstract: OBJECTIVE
  Recently, a novel multi-model monitor has been available, which integrates real-time signals of transcranial Doppler (TCD) and video-EEG (vEEG) into one workstation. We sought to test the feasibility of this device in detecting neurovascular coupling in patients with epilepsy.
  
  
  METHODS
  Cerebral blood flow velocity (CBFV) of bilateral middle cerebral arteries and vEEG during seizure episodes were recorded simultaneously in 12 patients (age 17-58 years) with partial epilepsies. The correlations between vEEG and CBFV findings were analyzed.
  
  
  RESULTS
  Eleven seizure episodes were detected in 5 patients. Of them, bilateral CBFV increase with interhemispheric asymmetry was observed in 4 seizure episodes of 3 patients. EEG abnormalities preceded CBFV increase by 1-3s at the onset of a seizure. In a patient with bilateral middle cerebral artery stenosis, no apparent CBFV changes were detected during 2 of 3 seizure episodes. Another patient with previous frontal hemorrhage displayed CBFV increase without interhemispheric asymmetry during 4 seizure episodes.
  
  
  CONCLUSIONS
  It is feasible to evaluate neurovascular coupling with good temporal correlation in patients with frequent seizure episodes by real-time TCD-vEEG monitoring.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: yypumc@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: luqiang@pumch.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lu
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: carlyangjlr@126.com.
authors.forename: Li-Ri
authors.initials: LR
authors.lastname: Jin
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: zhouxiangyioo@126.com.
authors.forename: Xiang-Qin
authors.initials: XQ
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: huangyan90@sina.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuaifuyuan 1, Dong Cheng District, Beijing 100730, China. Electronic address: xuwh@pumch.cn.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000503:physiopathology; D003251:Constriction, Pathologic / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000503:physiopathology; D064926:Neurophysiological Monitoring / Q000379:methods*; D000069336:Neurovascular Coupling / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*; D014741:Video Recording / Q000379:methods; D055815:Young Adult
keywords: Cerebral blood flow velocity; Electroencephalography; Neurovascular coupling; Partial seizures; Transcranial Doppler