title: Polymyxin-B-immobilized-fiber column hemoperfusion with oseltamivir treatment for ARDS due to influenza H1N1/09.
abstract: Acute respiratory distress syndrome (ARDS) is one of the severe complications of influenza H1N1/09 infection, resulting in high mortality. Effective treatment strategies for ARDS are needed. This report presents two cases of ARDS due to influenza in Vietnam. Both cases were similar in terms of starting symptoms, the rapid progression to ARDS, and the treatment strategy, direct hemoperfusion with a polymyxin-B-immobilized fiber column (PMX-DHP) and oseltamivir. However, the clinical course of disease and the outcomes were different. For case 1, treatment was initiated on day 4 following the onset of hypoxemia due to ARDS. Symptoms improved rapidly after treatment and the patient was discharged on day 12. For case 2, treatment was initiated on day 9 after the onset of symptoms. Despite intensive therapy, the patient died on day 18. In conclusion, treatment with PMX-DHP and oseltamivir is effective on ARDS due to influenza but only if initiated early.
authors.affiliation: Intensive Care Unit, Bach Mai Hospital Hanoi, Vietnam.
authors.forename: Nguyen Gia
authors.initials: NG
authors.lastname: Binh
authors.affiliation: Organization for Asian Study, Waseda University Tokyo, Japan ; Department of Pulmonary Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba Tsukuba, Ibaraki, Japan.
authors.forename: Toshie
authors.initials: T
authors.lastname: Manabe
authors.affiliation: Intensive Care Unit, Bach Mai Hospital Hanoi, Vietnam.
authors.forename: Dao Xuan
authors.initials: DX
authors.lastname: Co
authors.affiliation: Intensive Care Unit, Bach Mai Hospital Hanoi, Vietnam.
authors.forename: Nguyen Dang
authors.initials: ND
authors.lastname: Tuan
authors.affiliation: Intensive Care Unit, Bach Mai Hospital Hanoi, Vietnam.
authors.forename: Pham The
authors.initials: PT
authors.lastname: Thach
authors.affiliation: Organization for Asian Study, Waseda University Tokyo, Japan ; Department of Pulmonary Medicine, Fukujuji Hospital Tokyo, Japan ; Department of Pulmonary Medicine and Infection Control, Koto Hospital Tokyo, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
keywords: Acute respiratory distress syndrome (ARDS); PaO2/FiO2; influenza; oseltamivir; polymyxin-B-immobilized fiber column (PMX-DHP)