title: Combination of dynamic (11)C-PIB PET and structural MRI improves diagnosis of Alzheimer's disease.
abstract: Structural magnetic resonance imaging (sMRI) is an established technique for measuring brain atrophy, and dynamic positron emission tomography with (11)C-Pittsburgh compound B ((11)C-PIB PET) has the potential to provide both perfusion and amyloid deposition information. It remains unclear, however, how to better combine perfusion, amyloid deposition and morphological information extracted from dynamic (11)C-PIB PET and sMRI with the goal of improving the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). We adopted a linear sparse support vector machine to build classifiers for distinguishing AD and MCI subjects from cognitively normal (CN) subjects based on different combinations of regional measures extracted from imaging data, including perfusion and amyloid deposition information extracted from early and late frames of (11)C-PIB separately, and gray matter volumetric information extracted from sMRI data. The experimental results demonstrated that the classifier built upon the combination of imaging measures extracted from early and late frames of (11)C-PIB as well as sMRI achieved the highest classification accuracy in both classification studies of AD (100%) and MCI (85%), indicating that multimodality information could aid in the diagnosis of AD and MCI.
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Linwen
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Geriatric Neurology, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Baixuan
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, the Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jiahe
authors.initials: J
authors.lastname: Tian
authors.affiliation: Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: yong.fan@ieee.org.
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis*; D000682:Amyloid / Q000378:metabolism; D000814:Aniline Compounds; D001284:Atrophy / Q000473:pathology; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D005260:Female; D066128:Gray Matter / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles
keywords: Alzheimer’s disease; Amyloid; PET imaging; Perfusion; Structural MRI