title: Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse.
abstract: Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future.
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Se Young
authors.initials: SY
authors.lastname: Jang
authors.affiliation: Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Han Ik
authors.initials: HI
authors.lastname: Bae
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.|BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Daegu, Korea.|Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease (DMRC), Kyungpook National University Hospital, Daegu, Korea.
authors.forename: In Kyu
authors.initials: IK
authors.lastname: Lee
authors.affiliation: Leading-Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease (DMRC), Kyungpook National University Hospital, Daegu, Korea.
authors.forename: Hwan Ki
authors.initials: HK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Cho
mesh_terms: D000368:Aged; D000818:Animals; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000601:surgery; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D064593:Heterografts / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D014183:Transplantation, Heterologous / Q000379:methods*
keywords: Cholangiocarcinoma; Endoscopic ultrasound-guided fine needle aspiration; Individualized medicine; Xenograft