title: [Optimization of pharmacological therapy for weakness syndrome in incurable patients].
abstract: In this work there is considered the possibility of correction of therapy for weakness syndrome in incurable patients with the use of drugs affecting dopamine and serotonin exchanges. It is showed that the use of 100 mg of ladasten, 16 mg of ondansetron orally per day and 50 mg of agomelatine per night is more effective in therapy for fatigue/weakness syndrome in incurable cancer patients compared to standard therapy.
authors.forename: A A
authors.initials: AA
authors.lastname: Ryazankina
authors.forename: S A
authors.initials: SA
authors.lastname: Rozengard
authors.forename: V A
authors.initials: VA
authors.lastname: Glushchenko
authors.forename: A P
authors.initials: AP
authors.lastname: Karitsky
authors.forename: A V
authors.initials: AV
authors.lastname: Kvashnin
mesh_terms: D000081:Acetamides / Q000008:administration & dosage*; D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000932:Antiemetics / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage; D004298:Dopamine / Q000378:metabolism; D004359:Drug Therapy, Combination; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007052:Ibuprofen / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D017294:Ondansetron / Q000008:administration & dosage*; D010431:Pentoxifylline / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000008:administration & dosage; D013577:Syndrome; D016896:Treatment Outcome; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000218:Adamantane; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000932:Antiemetics; D000970:Antineoplastic Agents; D003907:Dexamethasone; D004298:Dopamine; D006993:Hypnotics and Sedatives; D007052:Ibuprofen; D017294:Ondansetron; D010431:Pentoxifylline; D011837:Radiation-Protective Agents; D012701:Serotonin; D012702:Serotonin Antagonists; C493151:N-(2-adamantyl)-N-p-bromophenylamine; C084711:agomelatine; D009281:Naphthalenes