title: Grade of inflammation in boys with type 1 diabetes depends on the IVS1 -397T>C estrogen receptor α polymorphism.
abstract: OBJECTIVE
  The effect of estrogens is mediated by activation of estrogen receptors (ERs), which are expressed in many tissues. Because ER-α gene polymorphisms may exert different effects in childhood, in the present study we analyzed associations between the IVS1 -397T>C polymorphism and indicators of inflammatory response as well as late complications in boys with type 1 diabetes mellitus (DM1).
  
  
  RESULTS
  We examined 108 young boys with DM1 and 64 healthy age-matched control individuals. ER-α genotyping, as well as the CRP and IL-6 serum level and blood pressure, was analyzed. In our study boys with CC genotype had lower blood pressure and IL-6 and CRP serum levels. Similar results were obtained for DM1 boys with microvascular complications - the blood pressure and serum level of IL-6, but not CRP, were still lower in the CC patients.
  
  
  CONCLUSIONS
  Our findings suggest that the presence of -397T allele may indicate macro- and microvascular complications in DM1 boys, before the occurrence of first clinical symptoms.
authors.affiliation: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk. Electronic address: bartosz@gumed.edu.pl.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Słomiński
authors.affiliation: Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Myśliwska
authors.affiliation: Chair & Clinics of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Brandt
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha
keywords: Blood pressure diabetes type 1; Diabetes-related vascular complications; IVS1 −397T>C polymorphism; Inflammation diabetes type 1