title: Minocycline for the treatment of cutaneous silicone granulomas: A case report.
abstract: Silicone oil injections are often used for soft tissue augmentation and local and general adverse effects occurring from a few months to 15 years after injection have been reported. Here, we present a case of delayed granuloma formation due to liquid injectable silicone with large extent of involvement, which precluded surgical removal. Our patient was successfully treated with minocycline, considering its anti-inflammatory, immunomodulating and antigranulomatous properties. This case presents minocycline monotherapy as a useful treatment option for the management of severe granuloma induced by silicone use when surgical excision is not possible.
authors.affiliation: a Sector of Cosmetic Dermatology, Clinic of Dermatology, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Elisete
authors.initials: E
authors.lastname: Crocco
authors.affiliation: b Specialization program at the Clinic of Dermatology, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Mirella
authors.initials: M
authors.lastname: Pascini
authors.affiliation: b Specialization program at the Clinic of Dermatology, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: c Voluntary program at the Clinic of Dermatology, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Alves
authors.affiliation: c Voluntary program at the Clinic of Dermatology, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Thais
authors.initials: T
authors.lastname: Proença
authors.affiliation: d Pathology Department, Santa Casa de São Paulo Hospital and School of Medicine , São Paulo-SP , Brazil.
authors.forename: Rute
authors.initials: R
authors.lastname: Lellis
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008911:Minocycline / Q000627:therapeutic use*; D012827:Silicone Oils / Q000009:adverse effects; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D012827:Silicone Oils; D008911:Minocycline
keywords: foreign-body granuloma; minocycline; silicone oils