title: To bet or not to bet: deciphering cell to cell variation in protozoan infections.
abstract: Some of the most crucial phenotypic aspects of parasites, such as an antigen-coated surface, parasite sexual differentiation, virulence, and drug resistance, rely on adaptive plasticity and/or stochastic events. At a population level, cell to cell variability represents an avenue for rapid response to drastic changes in the environment. Single cell approaches can be used to unravel the different strategies used by parasites to survive in the context of regulated transcriptional control (apicomplexa) or in its absence (kinetoplastids).
authors.affiliation: Biochemistry and Molecular Parasitology Research Group, Department of Parasitology, University of Granada, Campus de Fuentenueva, Granada, Spain.
authors.forename: Víctor
authors.initials: V
authors.lastname: Seco-Hidalgo
authors.affiliation: Biochemistry and Molecular Parasitology Research Group, Department of Parasitology, University of Granada, Campus de Fuentenueva, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Osuna
authors.affiliation: Biochemistry and Molecular Parasitology Research Group, Department of Parasitology, University of Granada, Campus de Fuentenueva, Granada, Spain; Centre for Immunology and Infection (CII), Biology Department, University of York, York, UK. Electronic address: luis.depablostorro@york.ac.uk.
authors.forename: Luis Miguel De
authors.initials: LM
authors.lastname: Pablos
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006790:Host-Parasite Interactions / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010274:Parasitology / Q000639:trends; D010641:Phenotype; D011528:Protozoan Infections / Q000469:parasitology*; D059010:Single-Cell Analysis
keywords: Leishmania; Plasmodium; Trypanosoma; cellular heterogeneity; gene expression; protozoan