title: Inverse Association Between Serum Uric Acid Levels and Alzheimer's Disease Risk.
abstract: The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2014, were searched in PubMed, Embase, and China Biology Medicine (CBM) databases. Study-specific data were combined using random-effects or fixed-effects models of meta-analysis according to between-study heterogeneity. Twenty-four studies (21 case-control and 3 cohort studies) were finally included into the meta-analysis. Those 21 case-control studies included a total of 1128 cases of Alzheimer's disease and 2498 controls without Alzheimer's disease. Those 3 cohort studies included a total of 7327 participants. Meta-analysis showed that patients with Alzheimer's disease had lower levels of uric acid than healthy controls (weighted mean difference (WMD) = -0.77 mg/dl, 95% CI -2.28 to -0.36, P = 0.0002). High serum uric acid levels were significantly associated with decreased risk of Alzheimer's disease (risk ratio (RR) = 0.66, 95% CI 0.52-0.85, P = 0.001). There was low risk of publication bias in the meta-analysis. There is an inverse association between serum uric acid levels and Alzheimer's disease. High serum uric acid level is a protective factor of Alzheimer's disease.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Na
authors.initials: N
authors.lastname: Du
authors.affiliation: Department of Rheumatology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China.
authors.forename: Donghua
authors.initials: D
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Xuejia
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Cancan
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China. nlwang@126.com.
authors.forename: Yangang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Physiology, Functional Laboratory of Weifang Medical University, Weifang, 261031, China. lx2005008@126.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D017594:Publication Bias; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Alzheimer’s disease; Meta-analysis; Uric acid