title: An update on miRNAs as biological and clinical determinants in colorectal cancer: a bench-to-bedside approach.
abstract: Colorectal carcinogenesis represents a sequential progression of normal colonic mucosa from adenoma to carcinoma. It has become apparent that miRNA deregulation contributes to the initiation and progression of colorectal cancer (CRC). These oncogenic or tumor-suppressive miRNAs interact with intracellular signaling networks and lead to alteration of cell proliferation, apoptosis, metastasis and even response to chemotherapeutic treatments. This article aims to review the cutting edge progress in the discovery of the role of novel mechanisms for miRNAs in the development of CRC. We will also discuss the potential use of miRNAs as biomarkers for early diagnosis and prognosis of CRC. Furthermore, with advancements in RNA delivery technology, it is anticipated that manipulation of miRNAs may offer an alternative therapy for CRC treatment.
authors.affiliation: Department of Clinical Laboratory, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai 200072, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Weng
authors.affiliation: Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Junlan
authors.initials: J
authors.lastname: Feng
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, 301 Yanchang Road, Shanghai 200072, China.
authors.forename: Huanlong
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, 301 Yanchang Road, Shanghai 200072, China.
authors.forename: Yanlei
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Center for Gastrointestinal Research & Center for Epigenetics, Cancer Prevention & Cancer Genomics, Baylor Research Institute & Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Goel
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D034622:RNA Interference
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: carcinogenesis; clinical application; colorectal cancer; diagnosis; miRNA; predictive biomarkers; prognosis