title: Choosing the right species in research.
abstract: When designing animal studies, investigators must choose a species that is appropriate for the research. In this paper, the author examines various criteria that can be used to guide this selection. He discusses the concepts of phylogenetic group and sentience and finds them not to be useful in the selection of appropriate species in biomedical research. He identifies other criteria that are more useful as justifications for species selection, including susceptibility to a targeted disease process, tendency to engage in a targeted behavior, suitable size for the experimental techniques to be used, presence of a large body of data relevant to the study, species specificity (the species itself is the target of the research), intergenerational interval, similarity to humans, contractual specification and existing guidelines. He proposes that investigators should use these justifications, and perhaps others, to choose the most scientifically appropriate species for animal studies.
authors.affiliation: 1] Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE. [2] CITI Program, University of Miami, Miami, FL.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mann
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000145:classification / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D035843:Biomedical Research / Q000379:methods* / Q000592:standards; D010802:Phylogeny; D012107:Research Design / Q000592:standards