title: Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics.
abstract: Glycans are everywhere in biological systems, being involved in many cellular events with important implications for medical purposes. Building upon a detailed understanding of the functional roles of carbohydrates in molecular recognition processes and disease states, glycans are increasingly being considered as key players in pharmacological research. On the basis of the important progress recently made in glycochemistry, glycobiology, and glycomedicine, we provide a complete overview of successful applications and future perspectives of carbohydrates in the biopharmaceutical and medical fields. This review highlights the development of carbohydrate-based diagnostics, exemplified by glycan imaging techniques and microarray platforms, synthetic oligosaccharide vaccines against infectious diseases (e.g., HIV) and cancer, and finally carbohydrate-derived therapeutics, including glycomimetic drugs and glycoproteins.
authors.affiliation: Chemical and Physical Biology, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid (Spain). aftejada@cib.csic.es.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández-Tejada
authors.affiliation: Chemical and Physical Biology, CIB-CSIC, Ramiro de Maeztu 9, 28040 Madrid (Spain).
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Cañada
authors.affiliation: Infectious Disease Programme, Center for Cooperative Research in Biosciences, CIC-bioGUNE, Bizkaia Technology Park, 48160 Derio (Spain). jjbarbero@cicbiogune.es.|Ikerbasque, Basque Foundation for Science, María López de Haro 13, 48009 Bilbao (Spain). jjbarbero@cicbiogune.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Jiménez-Barbero
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D019937:Diagnostic Techniques and Procedures; D055808:Drug Discovery / Q000379:methods*; D054794:Glycomics / Q000379:methods*; D006023:Glycoproteins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000517:prevention & control; D014612:Vaccines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D002241:Carbohydrates; D006023:Glycoproteins; D014612:Vaccines
keywords: carbohydrate chemistry; chemical glycobiology; glycodiagnostics; glycomimetics; therapeutic glycoproteins; vaccines