title: Remote-Controllable Explosive Polymer Multilayer Tubes for Rapid Cancer Cell Killing.
abstract: Gold nanoshell-functionalized polymer multilayer tubes can be used as potent therapeutic agents for remote killing of cancer cells in a controlled manner due to the emerging pressure wave and tube fragments piercing the cell wall. The explosion is based on rapid evaporation of water inside the tubes caused by photothermal effects. The mechanism of explosion is presented in theory and experiment. The explosion of the tubes depends on the absorption coefficient and size of the gold nanoshells in the tubes, whereby the placement of the gold particles inside or outside of the tubes has no obvious effect on the explosive properties.
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Changyong
authors.initials: C
authors.lastname: Gao
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Johannes
authors.initials: J
authors.lastname: Frueh
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Sun
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Yikuang Street 2, Harbin, 150080, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D057145:Nanoshells; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers
keywords: cancer therapy; explosion; layer-by-layer; photothermal effects; polyelectrolyte multilayers