title: Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice.
abstract: Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model.
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Bollmann
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Jäckel
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Schmidtke
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Schrick
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Reinhardt
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Jurk
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Ning
authors.initials: N
authors.lastname: Xia
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Huige
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Molecular Biotechnology and Systems Biology, Technical University Kaiserslautern, Kaiserslautern, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Erkel
authors.affiliation: Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Walter
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Kleinert
authors.affiliation: Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Pautz
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001057:Apolipoproteins E / Q000235:genetics; D050197:Atherosclerosis / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects; D002339:Carotid Arteries / Q000473:pathology*; D002341:Carotid Artery Thrombosis / Q000188:drug therapy*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D007783:Lactones / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010973:Platelet Adhesiveness / Q000187:drug effects; D014914:Whole Blood Coagulation Time
chemical_list: D000893:Anti-Inflammatory Agents; D001057:Apolipoproteins E; D016207:Cytokines; D005343:Fibrinolytic Agents; D007783:Lactones; C416043:galiellalactone