title: Inhibition control impairments in adolescent smokers: electrophysiological evidence from a Go/NoGo study.
abstract: Smoking during adolescence may promote nicotine dependence later on in life. Therefore, it is extremely important to study the neural mechanisms of adolescent smokers. As inhibition control is emphasized in several contemporary theoretical models of addiction, in the current study, we focused on the electrophysiological evidence of inhibition control deficits in adolescent smokers. By using relatively homogenous groups of adolescent smokers (n = 18) and matched nonsmokers (n = 18), we employed event-related potentials (ERP) to investigate the N200 and P300 amplitude and latency differences during a Go/NoGo task between the adolescent smokers and nonsmokers. Relative to nonsmokers, more NoGo response errors, reduced NoGo P300 amplitude, and longer P300 latency were observed in adolescent smokers. Correlation analysis revealed that the NoGo P300 amplitudes were significantly correlated with NoGo errors in both adolescent smokers and nonsmokers. Our findings provided direct electrophysiological evidence for inhibitory control impairments in adolescent smokers. It is hoped that our results may enhance understanding of the pathology of inhibitory control in adolescent smokers.
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Junsen
authors.initials: J
authors.lastname: Yin
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China. kyuan@xidian.edu.cn.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. kyuan@xidian.edu.cn.|Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. kyuan@xidian.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Yuan
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Feng
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Jiadong
authors.initials: J
authors.lastname: Cheng
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Yangding
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Cai
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Bi
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Shi
authors.initials: S
authors.lastname: Sha
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Shen
authors.affiliation: School of Mechanical, Sanjiang University, Nanjing, Jiangsu, 210012, People's Republic of China.
authors.forename: Ben
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xue
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. fmydh1@gmail.com.
authors.forename: Dahua
authors.initials: D
authors.lastname: Yu
authors.affiliation: Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Lu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an Shaanxi, 710071, People's Republic of China.|Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.|Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
mesh_terms: D000293:Adolescent; D001921:Brain / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D011930:Reaction Time; D012907:Smoking / Q000009:adverse effects / Q000523:psychology*
keywords: Adolescent smokers; Event-related potentials (ERP); Go/NoGo task; Inhibition control; N200; P300