title: Infectious asthma triggers: time to revise the hygiene hypothesis?
abstract: The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later in life. This reignites discussions on infection-mediated asthma phenotypes and potential therapeutics.
authors.affiliation: University of Massachusetts Amherst, Amherst, MA, USA. Electronic address: wilmore@microbio.umass.edu.
authors.forename: Wilmore C
authors.initials: WC
authors.lastname: Webley
authors.affiliation: University of Massachusetts Amherst, Amherst, MA, USA.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Aldridge
mesh_terms: D001249:Asthma / Q000453:epidemiology*; D006801:Humans; D064307:Microbiota; D009305:Nasopharynx / Q000382:microbiology* / Q000821:virology*; D012141:Respiratory Tract Infections / Q000473:pathology*
keywords: asthma; hygiene hypothesis; microbiome; respiratory infection