title: Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report.
abstract: Familial hemiplegic migraine (FHM) is a rare autosomal dominant form of migraine with motor aura. We present a case report of a father and son with very similar attacks of hemiplegic migraine and recurrent episodes of accompanying psychoses. Previously, such episodes led to hospitalization and extended clinical examinations, which further worsened the psychoses. Since the episodes were recognized as related to the hemiplegic migraine, a treatment strategy combining sleep and sedation was initiated and progression onto psychosis was almost completely avoided in both father and son. Genetic analyses found no causal gene mutation in the three known FHM genes, suggesting that the phenotype is caused by a yet unidentified mutation.
authors.affiliation: Danish Headache Center, Department of Neurology Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
authors.forename: Sonja
authors.initials: S
authors.lastname: LaBianca
authors.affiliation: Danish Headache Center, Department of Neurology Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
authors.forename: Rigmor
authors.initials: R
authors.lastname: Jensen
authors.affiliation: Departments of Human Genetics & Neurology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Arn M J M
authors.initials: AM
authors.lastname: van den Maagdenberg
authors.affiliation: Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
authors.forename: Lone
authors.initials: L
authors.lastname: Baandrup
authors.affiliation: Danish Headache Center, Department of Neurology Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Bendtsen
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D011618:Psychotic Disorders / Q000209:etiology* / Q000517:prevention & control
keywords: delirium; familial hemiplegic migraine; psychosis