title: Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.
abstract: G-protein-coupled receptors (GPCRs) are frequent and fruitful targets for drug discovery and development, as well as being off-targets for the side effects of a variety of medications. Much of the druggable non-olfactory human GPCR-ome remains under-interrogated, and we present here various approaches that we and others have used to shine light into these previously dark corners of the human genome.
authors.affiliation: From the Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27514 bryan_roth@med.unc.edu.
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.affiliation: From the Department of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina 27514.
authors.forename: Wesley K
authors.initials: WK
authors.lastname: Kroeze
mesh_terms: D001665:Binding Sites; D016206:Databases, Bibliographic; D062126:Databases, Chemical; D062313:Databases, Pharmaceutical; D015507:Drugs, Investigational / Q000138:chemical synthesis / Q000494:pharmacology*; D015894:Genome, Human; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D020543:Proteome / Q000737:chemistry* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D015507:Drugs, Investigational; D008024:Ligands; D020543:Proteome; D043562:Receptors, G-Protein-Coupled; D054852:Small Molecule Libraries
keywords: G-protein-coupled receptor (GPCR); chemical biology; cheminformatics; disease; druggable genome; functional genomics; molecular pharmacology; neurological disease