title: Blood biochemical changes in pigs after infusion with acetate-buffered or lactate-buffered crystalloid solutions.
abstract: Perioperative fluid therapy is an important component of many medical procedures with animals. Buffered crystalloid solutions avoid inducing metabolic acidosis, but lactated solutions can elevate blood lactate concentrations and acetated solutions have not been thoroughly investigated using large animals. Here, the authors compare blood biochemical parameters in 20 juvenile pigs after perioperative fluid administration of an acetate-buffered solution (Elo-Mel isoton, EMI) or a lactate-buffered solution (lactated Ringer's solution, LRS). The authors measured blood lactate, glucose and electrolyte concentrations before and after administering the test fluid during surgery. Blood lactate concentration after administration was significantly higher in pigs that received LRS than in pigs that received EMI, but glucose and electrolyte concentrations did not differ significantly between treatment groups before or after administration. These findings suggest that EMI might be a preferable option for perioperative fluid therapy in pigs.
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Keibl
authors.affiliation: University of Veterinary Medicine Vienna, Department for Farm Animals and Veterinary Public Health, Vienna, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sipos
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Ponschab
authors.affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria.
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Schlimp
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001769:Blood / Q000187:drug effects*; D001774:Blood Chemical Analysis; D000077324:Crystalloid Solutions; D006403:Hematologic Tests; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D000077325:Ringer's Lactate; D013552:Swine
chemical_list: D000085:Acetates; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D000077325:Ringer's Lactate