title: Fluorinated enol ethers: their synthesis and reactivity.
abstract: Thanks to the beneficial effect of fluorine substitution on the pharmacokinetic properties of molecules, an ever increasing number of marketed drugs incorporate a fluorine atom into their structure. As a consequence, the synthesis of fluorinated molecules has become a very active research field. Among the numerous approaches, fluorinated enol ethers are valuable building blocks that allow the introduction of a fluoro- or difluoromethyl group through a wide variety of reactions. The present review lists different methods for their preparation and sums up their numerous synthetic applications.
authors.affiliation: Institut Charles Gerhardt UMR 5253 CNRS-UM2-UM1-ENSCM 8, rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France. eric.leclerc@enscm.fr.
authors.forename: M
authors.initials: M
authors.lastname: Decostanzi
authors.forename: J-M
authors.initials: JM
authors.lastname: Campagne
authors.forename: E
authors.initials: E
authors.lastname: Leclerc