title: Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.
abstract: Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin is sensed down to 1 × 10(-13) m, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.
authors.affiliation: 3415 Colorado Ave., UCB 596, Boulder, CO, 80303, USA.
authors.forename: Rajarshi
authors.initials: R
authors.lastname: Chattaraj
authors.affiliation: 3415 Colorado Ave., UCB 596, Boulder, CO, 80303, USA.
authors.forename: Praveena
authors.initials: P
authors.lastname: Mohan
authors.affiliation: 3415 Colorado Ave., UCB 596, Boulder, CO, 80303, USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Besmer
authors.affiliation: 3415 Colorado Ave., UCB 596, Boulder, CO, 80303, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Goodwin
mesh_terms: D015415:Biomarkers / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods*; D001710:Biotin / Q000378:metabolism; D005466:Fluorocarbons / Q000737:chemistry*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D019809:Streptavidin / Q000378:metabolism; D014465:Ultrasonics; D014835:Volatilization
chemical_list: D015415:Biomarkers; D005466:Fluorocarbons; D001710:Biotin; D019809:Streptavidin
keywords: biomedical applications; biosensors; colloids; self-assembly; stimuli-responsive materials