title: NSAID Use and Incident Cognitive Impairment in a Population-based Cohort.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) may prevent dementia, but previous studies have yielded conflicting results. This study estimated the association of prior NSAID use with incident cognitive impairment in the population-based Epidemiology of Hearing Loss Study (EHLS, n=2422 without cognitive impairment in 1998-2000). Prospectively collected medication data from 1988-1990, 1993-1995, and 1998-2000 were used to categorize NSAID use history at the cognitive baseline (1998-2000). Aspirin use and nonaspirin NSAID use were separately examined. Cox regression models were used to estimate the associations between NSAID use history at baseline and incident cognitive impairment in 2003-2005 or 2009-2010. Logistic regression analyses were used to estimate associations with a second outcome, mild cognitive impairment/dementia, available in 2009-2010. Participants using aspirin at baseline but not 5 years prior were more likely to develop cognitive impairment (adjusted hazard ratio=1.77; 95% confidence interval=1.11, 2.82; model 2), with nonsignificant associations for longer term use. Nonaspirin NSAID use was not associated with incident cognitive impairment or mild cognitive impairment/dementia odds. These results provided no evidence to support a potential protective effect of NSAIDs against dementia.
authors.affiliation: Departments of *Population Health Sciences§Ophthalmology and Visual Sciences#Biostatistics and Medical Informatics∥Medicine, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health†Institute on Aging**Department of Statistics, University of Wisconsin‡Wisconsin Alzheimer's Disease Research Center (ADRC)¶Veterans Affairs Geriatric Research, Education and Clinical Center (GRECC), Madison, WI.
authors.forename: Margarete A
authors.initials: MA
authors.lastname: Wichmann
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Cruickshanks
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Carlsson
authors.forename: Rick
authors.initials: R
authors.lastname: Chappell
authors.forename: Mary E
authors.initials: ME
authors.lastname: Fischer
authors.forename: Barbara E K
authors.initials: BE
authors.lastname: Klein
authors.forename: Ronald
authors.initials: R
authors.lastname: Klein
authors.forename: Carla R
authors.initials: CR
authors.lastname: Schubert
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000209:etiology; D003704:Dementia / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin