title: Comment on "Cholesterol solubility limit in lipid membranes probed by small angle neutron scattering and MD simulations" by S. Garg et al., Soft Matter, 2014, 10, 9313.
abstract: In a recent article, Garg et al. used neutron scattering techniques to determine the limiting amount of cholesterol which vesicles of either POPS or POPC can accommodate. This amount was called "the cholesterol solubility limit". In light of extensive literature on cholesterol phase separation in phospholipid bilayers, the way in which "solubility limit" is defined in this article and the conclusions derived are misleading and require some clarification.
authors.affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Canada. epand@mcmaster.ca.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Epand
authors.forename: Diana
authors.initials: D
authors.lastname: Bach
authors.forename: Ellen
authors.initials: E
authors.lastname: Wachtel
mesh_terms: D002784:Cholesterol / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D053835:Unilamellar Liposomes / Q000737:chemistry*
chemical_list: D053835:Unilamellar Liposomes; D002784:Cholesterol