title: Monitoring Dopamine Quinone-Induced Dopaminergic Neurotoxicity Using Dopamine Functionalized Quantum Dots.
abstract: Dopamine (DA) quinone-induced dopaminergic neurotoxicity is known to occur due to the interaction between DA quinone and cysteine (Cys) residue, and it may play an important a role in pathological processes associated with neurodegeneration. In this study, we monitored the interaction process of DA to form DA quinone and the subsequent Cys residue using dopamine functionalized quantum dots (QDs). The fluorescence (FL) of the QD bioconjugates changes as a function of the structure transformation during the interaction process, providing a potential FL tool for monitoring dopaminergic neurotoxicity.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.forename: Hui-Ting
authors.initials: HT
authors.lastname: Liu
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
mesh_terms: D003545:Cysteine / Q000032:analysis / Q000378:metabolism*; D004298:Dopamine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009498:Neurotoxins / Q000032:analysis / Q000378:metabolism*; D045663:Quantum Dots / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D018675:Toxicity Tests
chemical_list: D009498:Neurotoxins; C104705:dopamine quinone; D003545:Cysteine; D004298:Dopamine
keywords: cysteine residue; dopamine quinone; dopaminergic neurotoxicity; fluorescence; quantum dots