title: An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells.
abstract: Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine γ-lyase (CSE) and/or cystathionine β-synthase (CBS). Both CSE and CBS are expressed in rat gastric tissues but their role in human gastric neoplasia has been unclear. The aims of the present study were to detect CSE and CBS proteins in human gastric cancer and determine the effect of exogenous NaHS on the proliferation of gastric cancer cells. We found that both CSE and CBS proteins were expressed in human gastric cancer cells and upregulated in human gastric carcinoma mucosa compared with those in noncancerous gastric samples. NaHS induced apoptosis of gastric cancer cells by regulating apoptosis related proteins. Also, NaHS inhibited cancer cell migration and invasion. An antigastric cancer role of H2S is thus indicated.
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China.
authors.forename: Li
authors.identifier: 0000-0002-8968-8854
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China ; Department of Pathology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Qi
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China ; Department of Pathophysiology, Qiqihar Medical College, Qiqihar 161006, China.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Sun
authors.affiliation: Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Harbin Medical University, Harbin 150081, China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, the Third Affiliated Hospital, Harbin Medical University, Harbin 150081, China.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Oncology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China.
authors.forename: Qiuying
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin 150081, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003541:Cystathionine beta-Synthase / Q000235:genetics / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000235:genetics / Q000378:metabolism; D045304:Cytochromes c / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000633:toxicity*; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D015854:Up-Regulation; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D051028:bcl-2-Associated X Protein; D045304:Cytochromes c; D053148:Caspase 3; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide