title: Use of a Gonadotropin-releasing Hormone Analog to Treat Idiopathic Central Precocious Puberty Is Not Associated with Changes in Bone Structure in Postmenarchal Adolescents.
abstract: OBJECTIVE
  To evaluate bone quantity and quality in postmenarchal adolescents treated for idiopathic central precocious puberty (CPP) in childhood with a gonadotropin-releasing hormone analog (GnRHa) and to determine the serum concentrations of bone remodeling markers.
  
  
  METHODS
  This cross-sectional study included 53 postmenarchal adolescent girls who were divided into 2 groups: 27 adolescents who were treated with GnRHa in childhood for idiopathic CPP (the CPP group) and 26 women who presented with physiological development of secondary sex traits (the control group).
  
  
  METHODS
  None.
  
  
  METHODS
  Weight, height, body mass index, age at menarche, time since menarche, body composition, bone mineral density (BMD), bone quality, and serum insulin, glucose, osteocalcin, and carboxyl-terminal telopeptide of type I collagen concentrations were compared in the 2 groups. BMD data were analyzed by using both dual-energy x-ray absorptiometry (DXA) and osteosonography, and body composition was measure with the use of DXA and electrical bioimpedance.
  
  
  RESULTS
  BMD and bone quality did not differ significantly between the CPP and control groups when analyzed by using DXA or osteosonography. Serum osteocalcin concentration was significantly lower (P = .02) in the CPP than in the control group. Insulin was higher in the CPP group, and hyperinsulinemia was an independent predictor of bone quantity and quality assessed by using osteosonography. Body mass index and percent fat were determined by using DXA, and the duration of use of GnRHa treatment and the time since GnRHa discontinuation were not independent predictors of bone quantity and quality.
  
  
  CONCLUSIONS
  Postmenarchal adolescents treated with GnRHa for CPP in childhood did not show a reduction in bone quantity or quality.
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Renata
authors.initials: R
authors.lastname: Iannetta
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Anderson S
authors.initials: AS
authors.lastname: Melo
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Odilon
authors.initials: O
authors.lastname: Iannetta
authors.affiliation: Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Júlio S
authors.initials: JS
authors.lastname: Marchini
authors.affiliation: Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Paula
authors.affiliation: Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Martinelli
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Ana Carolina J S
authors.initials: AC
authors.lastname: Rosa e Silva
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Rui A
authors.initials: RA
authors.lastname: Ferriani
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
authors.forename: Wellington P
authors.initials: WP
authors.lastname: Martins
authors.affiliation: Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil. Electronic address: romareis@fmrp.usp.br.
authors.forename: Rosana M
authors.initials: RM
authors.lastname: Reis
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008572:Menarche; D011629:Puberty, Precocious / Q000188:drug therapy*
chemical_list: D015415:Biomarkers; D007987:Gonadotropin-Releasing Hormone
keywords: Bone collagen; Bone mass; Gonadotropin-releasing hormone analog; Osteocalcin; Precocious puberty