title: Kidney light chain disease in patients with the acquired immunodeficiency syndrome.
abstract: Light chain deposit disease (LCDD) is a rare condition caused by deposition of overproduced monoclonal light chains and has been frequently related to multiple myeloma or lymphocytic disorders. LCDD in association with human immunodeficiency virus (HIV) has only been described twice in the literature and is thought to result from HIV direct/indirect effects on B and T-cell populations, leading to chronic immune activation with paraprotein production. We report a renal LCDD case diagnosed at autopsy in a severely immunodepressed HIV patient and analyse renal histopathology of 18 HIV patients who had an autopsy in our department between 2000 and 2010.
authors.affiliation: Institute of Clinical Pathology, University Hospital, Geneva, Switzerland.
authors.forename: Raquel Vilarino
authors.initials: RV
authors.lastname: Villaverde
authors.affiliation: Department of Internal Medicine, University Hospital, Geneva, Switzerland.
authors.forename: Vincent
authors.initials: V
authors.lastname: Darioli
authors.affiliation: Department of Internal Medicine, University Hospital, Geneva, Switzerland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Hirschel
authors.affiliation: Institute of Clinical Pathology, University Hospital, Geneva, Switzerland.
authors.forename: Thomas Alexander
authors.initials: TA
authors.lastname: McKee
authors.affiliation: Institute of Clinical Pathology, University Hospital, Geneva, Switzerland.
authors.forename: Johannes Alexander
authors.initials: JA
authors.lastname: Lobrinus
authors.affiliation: Institute of Clinical Pathology, University Hospital, Geneva, Switzerland.
authors.forename: Solange
authors.initials: S
authors.lastname: Moll
keywords: HIV; light chain deposit disease (LCDD); renal pathology