title: Bilateral Nephrectomy for Autosomal Dominant Polycystic Kidney Disease and Timing of Kidney Transplant: A Review of the Technical Advances in Surgical Management of Autosomal Dominant Polycystic Disease.
abstract: Autosomal dominant polycystic disease is a multisystem inherited condition affecting the kidneys and is an important cause of end-stage renal disease. Patients with autosomal dominant polycystic disease experience symptoms related to size and cystic nature of their kidneys, which can be difficult to manage. Traditionally, the only surgical option for management was open bilateral/unilateral native nephrectomy, which carried with it significant morbidity and mortality. Therefore, it was deemed unsafe and rarely performed. However, surgery for autosomal dominant polycystic disease has evolved rapidly with the advent of minimally invasive surgery and improved medical management of end-stage renal failure patients. Laparoscopic and hand-assisted laparoscopic techniques have been adopted and have demonstrated reduced morbidity. The timing of this intervention in relation to transplant is controversial and presents a major challenge in managing this patient population.
authors.affiliation: London Postgraduate School of Surgery, London, UK.
authors.forename: Fungai
authors.initials: F
authors.lastname: Dengu
authors.forename: Bilal
authors.initials: B
authors.lastname: Azhar
authors.forename: Shaneel
authors.initials: S
authors.lastname: Patel
authors.forename: Nadey
authors.initials: N
authors.lastname: Hakim
mesh_terms: D004059:Diffusion of Innovation; D018450:Disease Progression; D058733:Hand-Assisted Laparoscopy / Q000639:trends; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000639:trends*; D009392:Nephrectomy / Q000009:adverse effects / Q000639:trends*; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D013997:Time Factors; D061665:Time-to-Treatment; D016896:Treatment Outcome