title: Impact of hydroxychloroquine on preterm delivery and intrauterine growth restriction in pregnant women with systemic lupus erythematosus: a descriptive cohort study.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of hydroxychloroquine (HCQ) on fetal preterm delivery and intrauterine growth restriction (IUGR) in a cohort of pregnant women with systemic lupus erythematosus (SLE).
  
  
  METHODS
  Over an 11-year period (January 1, 2001 to December 31, 2011), all women with SLE and admitted to deliver after 22 weeks of gestation to Bordeaux University Hospital (France), were retrospectively enrolled in the present study. The population was then split into two groups based on the treatment they received: HCQ exposed (HCQ+) versus HCQ non-exposed (HCQ-) group.
  
  
  RESULTS
  118 pregnancies were included, 41 in the HCQ+ group and 77 in the HCQ- group. The rate of adverse fetal outcome was significantly lower in the HCQ+ group (p = 0.001), particularly in terms of preterm delivery, 15.8% versus 44.2% (p = 0.006), and IUGR, 10.5% versus 28.6% (p = 0.03). No adverse outcomes were reported in the HCQ+ group.
  
  
  CONCLUSIONS
  HCQ reduces neonatal morbidity in women with SLE by significantly decreasing the rate of prematurity and intrauterine growth restriction.
authors.affiliation: Department of Gynecology and Obstetrics, La Reunion University Hospital, Saint Pierre, France leroux_mel@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Leroux
authors.affiliation: Department of Gynecology and Obstetrics, La Reunion University Hospital, Saint Pierre, France.
authors.forename: C
authors.initials: C
authors.lastname: Desveaux
authors.affiliation: Department of Anesthesiology and Critical Care, Gabriel Martin Hospital, Saint Paul, France.
authors.forename: M
authors.initials: M
authors.lastname: Parcevaux
authors.affiliation: Department of Anesthesiology, CHU de Bordeaux, Bordeaux, France.
authors.forename: B
authors.initials: B
authors.lastname: Julliac
authors.affiliation: Department of Neonatology and NICU, La Reunion University Hospital, Saint Pierre, France.
authors.forename: J B
authors.initials: JB
authors.lastname: Gouyon
authors.affiliation: Department of Gynecology and Obstetrics, CHU de Bordeaux, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Dallay
authors.affiliation: Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
authors.affiliation: Department of Gynecology and Obstetrics, La Reunion University Hospital, Saint Pierre, France.
authors.forename: M
authors.initials: M
authors.lastname: Boukerrou
authors.affiliation: Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Blanco
authors.affiliation: Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
authors.forename: E
authors.initials: E
authors.lastname: Lazaro
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced* / Q000175:diagnosis*; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000009:adverse effects*; D007234:Infant, Premature; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000139:chemically induced*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D006886:Hydroxychloroquine; D011241:Prednisone
keywords: Systemic lupus erythematosus; hydroxychloroquine; intrauterine growth restriction; pregnancy; prematurity