title: [Application value of core needle biopsy technique in the pathological diagnosis of locally advanced pancreatic cancer].
abstract: OBJECTIVE
  To explore the application value of core needle biopsy technique in the pathological diagnosis of locally advanced pancreatic cancer patients.
  
  
  METHODS
  During April 2007 to April 2014, retrospective analysis was conducted for 36 patients of locally advanced pancreatic cancer to summarize the clinical data of core needle biopsy technique. And the relevant data included clinical features, pathological findings and puncture-related complications. Regular postoperative follow-ups were conducted.
  
  
  RESULTS
  All received pathological examination of core needle biopsy. And the pathological diagnoses were pancreatic cancer (n=29), pancreatic neuroendocrine tumors (n=2) and chronic pancreatitis (n=5). During the follow-ups, liver metastasis was pathologically confirmed postoperatively at Months 4 and 6 months among 5 chronic pancreatitis patients. The remainder was followed up for over 12 months. There was neither change in size nor metastasis. One case was diagnosed at Peking Union Hospital as autoimmune pancreatitis while another 2 cases had a clinical diagnosis of chronic pancreatitis. The accuracy of core needle puncture was 94.4%. There were 2 cases of postoperative pancreatic fistula in class A. Bleeding complication was absent.
  
  
  CONCLUSIONS
  The application of core needle biopsy technique is both safe and effective in the pathological diagnosis of locally advanced pancreatic cancer.
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing 100021, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Che
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing 100021, China.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing 100021, China.
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing 100021, China.
authors.forename: Yuemin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing 100021, China; Email: wangcf369@medmail.com.cn.
authors.forename: Chengfeng
authors.initials: C
authors.lastname: Wang
mesh_terms: D001327:Autoimmune Diseases; D062005:Biopsy, Large-Core Needle; D006801:Humans; D008113:Liver Neoplasms; D010190:Pancreatic Neoplasms; D050500:Pancreatitis, Chronic; D012189:Retrospective Studies