title: Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.
abstract: Four new iodobenzene-containing dipeptides (1-4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea. The structures of these novel compounds, designated as apliamides A-E (1-5) and apliamine A (6) were determined via combined spectroscopic analyses. The absolute configuration of the amino acid residue in 1 was determined by advanced Marfey's analysis. Several of these compounds exhibited moderate cytotoxicity and significant inhibition against Na+/K+-ATPase (4).
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. wth123@snu.ac.kr.
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Won
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. kck1006@snu.ac.kr.
authors.forename: Chang-Kwon
authors.initials: CK
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. awhee84@naver.com.
authors.forename: So-Hyoung
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Biological Science, College of Life Science, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun, Seoul 120-750, Korea. nhm@ewha.ac.kr.
authors.forename: Boon Jo
authors.initials: BJ
authors.lastname: Rho
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. sklee61@snu.ac.kr.
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. ohkibong@snu.ac.kr.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007462:Iodobenzenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013057:Spectrum Analysis; D014561:Urochordata / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D004151:Dipeptides; D007462:Iodobenzenes; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Aplidium sp.; Marfey’s analysis; apliamides; bioactivities; dipeptides