title: [Historical compilation of cystic fibrosis].
abstract: Cystic fibrosis is the most common life-shortening recessively inherited disorder in the Caucasian population. The genetic mutation that most frequently provokes cystic fibrosis (ΔF508) appeared at least 53,000years ago. For many centuries, the disease was thought to be related to witchcraft and the "evil eye" and it was only in 1938 that Dorothy H. Andersen characterized this disorder and suspected its genetic origin. The present article reviews the pathological discoveries and diagnostic and therapeutic advances made in the last 75 years. The review ends with some considerations for the future.
authors.affiliation: Consultor sénior jubilado, Servicio de Gastroenterología, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, Barcelona, España. Electronic address: 6119snc@comb.cat.
authors.forename: Salvador
authors.initials: S
authors.lastname: Navarro
mesh_terms: D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000266:history* / Q000628:therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: Cystic fibrosis; Fibrosis quística; Gene therapy; Historia; History; Lung transplant; Prueba del sudor; Sweat test; Terapia génica; Trasplante pulmonar