title: Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers.
abstract: OBJECTIVE
  To evaluate the relationship of endometrial thickness (EnT) and endometrial pattern (EnP) to euploid embryo transfer (ET) outcomes.
  
  
  METHODS
  Retrospective cohort.
  
  
  METHODS
  Private academic clinic.
  
  
  METHODS
  Patients (n = 277; age 36.1 ± 4.0 years) whose embryos (n = 476) underwent aneuploidy screening with fresh (n = 176) or frozen (n = 180) ET from July 2010 to March 2014.
  
  
  METHODS
  The EnT and EnP were measured on trigger day and at ET. Patients were stratified by age and cycle type (fresh or frozen). Cycle data were combined at trigger day, but separated at ET day.
  
  
  METHODS
  Outcome measures were implantation rate, pregnancy rate, and clinical pregnancy rate. Analysis was conducted using χ(2) analysis and Fisher's exact test.
  
  
  RESULTS
  A total of 234 gestational sacs, 251 pregnancies, and 202 clinical pregnancies resulted from 356 cycles. The EnT (9.6 ± 1.8 mm; range: 5-15 mm) at trigger day (n = 241 cycles), as a continuous or categorical variable (≤8 vs. >8 mm), was not associated with implantation rate, pregnancy rate, or clinical pregnancy rate. The EnT at day of fresh ET (9.7 ± 2.2 mm; range: 4.4-17.9 mm) (n = 176 cycles) or frozen ET (9.1 ± 2.1 mm; range: 4.2-17.7 mm) (n = 180 cycles) was not associated with implantation rate, pregnancy rate, or clinical pregnancy rate. Type 3 EnP at trigger day was associated with increased serum progesterone at trigger and a decreased implantation rate, compared with type 2 EnP. The EnP at fresh or frozen ET was not associated with implantation rate, pregnancy rate, or clinical pregnancy rate.
  
  
  CONCLUSIONS
  Within the study population, EnT was not significantly associated with clinical outcomes of euploid ETs. A type 3 EnP at trigger day suggests a prematurely closed window of implantation.
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: gingolj@ccf.org.
authors.forename: Julian A
authors.initials: JA
authors.lastname: Gingold
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Lee
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York.
authors.forename: Jorge
authors.initials: J
authors.lastname: Rodriguez-Purata
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Whitehouse
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Sandler
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Grunfeld
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Mukherjee
authors.affiliation: Reproductive Medicine Associates of New York, New York, New York; Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Copperman
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology*; D016009:Chi-Square Distribution; D015925:Cryopreservation; D046149:Embryo Culture Techniques; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D005820:Genetic Testing; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D008423:Maternal Age; D011003:Ploidies; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Endometrial thickness; endometrial pattern; implantation rate; pregnancy rate; preimplantation genetic screening