title: Gut Microbiota: Association with NAFLD and Metabolic Disturbances.
abstract: Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia. Recent lines of evidence have demonstrated a role of gut microbiota in insulin resistance, obesity, and associated metabolic disturbances, raising the interest in its relationship with NAFLD pathogenesis. Therefore, intestinal microbiota has emerged as a potential factor involved in NAFLD, through different pathways, including its influence in energy storage, lipid and choline metabolism, ethanol production, immune balance, and inflammation. The main objective of this review is to address the pathogenic association of gut microbiota to NAFLD. This comprehension may allow the development of integrated strategies to modulate intestinal microbiota in order to treat NAFLD.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Institute for Research and Innovation in Health Sciences, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Lau
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Institute for Research and Innovation in Health Sciences, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: D
authors.initials: D
authors.lastname: Carvalho
authors.affiliation: Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Institute for Research and Innovation in Health Sciences, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Freitas
mesh_terms: D000069196:Gastrointestinal Microbiome; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D024821:Metabolic Syndrome / Q000382:microbiology / Q000503:physiopathology*; D065626:Non-alcoholic Fatty Liver Disease / Q000382:microbiology / Q000503:physiopathology*