title: Interval training based on ventilatory anaerobic threshold improves aerobic functional capacity and metabolic profile: a randomized controlled trial in coronary artery disease patients.
abstract: BACKGROUND
  Exercise training has been an essential component of cardiac rehabilitation. However, it is not known if interval training (IT) based on the ventilatory anaerobic threshold (VAT) could be effective in improving aerobic functional capacity and metabolic profile in patients without or with coronary artery disease (CAD).
  
  
  OBJECTIVE
  To investigate the effects of an IT program, based-intensity between 70-110% of workload reached at the VAT, on the aerobic functional capacity and metabolic profile of patients with and without CAD.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Outpatients from a cardiac rehabilitation.
  
  
  METHODS
  A sample was composed of 32 patients with CAD (CAD group) and 32 patients without CAD (noCAD group) that were randomized into a trained or control groups.
  
  
  METHODS
  Submaximal cardiopulmonary exercise test on the cycle ergometer and blood samples were realized at baseline and post 16 weeks of IT program. The cardiorespiratory variables were obtained at the VAT level. Trained groups (CAD-T, N.=15; noCAD-T, N.=15) underwent a supervised three-week session IT program (30-40 minutes each exercise session, at the intensity workloads equivalent to %VAT [70-110%]) for 16 weeks.
  
  
  RESULTS
  After 16 weeks of IT program, there were a significant increase of VO(2VAT) and workload in the trained groups (P<0.05), while in the control groups VO(2VAT) and heart rate decreased (P<0.05). Body mass and body index mass decreased in trained groups (P<0.05), and low-density lipoprotein increased only in noCAD group after 16 weeks (P<0.05). The magnitude of the improvement in VO(2VAT) was related to VO(2VAT) (r=-0.57, P<0.05) and workload (r=-0.52, P<0.05) at baseline.
  
  
  CONCLUSIONS
  The IT program prescribed with intensities based on VAT improved the aerobic functional capacity and decreased body mass and body index mass loss in patients with and without CAD.
  
  
  CONCLUSIONS
  IT program based on VAT provides new possibilities for cardiac rehabilitation in relation to individualized exercise prescription of the interval training.
authors.affiliation: Nucleus of Research in Physical Exercise, Department of Physical Therapy, Federal University of São Carlos, São Carlos, Brazil - nayaratamburus@hotmail.com.
authors.forename: Nayara Y
authors.initials: NY
authors.lastname: Tamburús
authors.forename: Vandeni C
authors.initials: VC
authors.lastname: Kunz
authors.forename: Mariana R
authors.initials: MR
authors.lastname: Salviati
authors.forename: Viviane
authors.initials: V
authors.lastname: Castello Simões
authors.forename: Aparecida M
authors.initials: AM
authors.lastname: Catai
authors.forename: Ester
authors.initials: E
authors.lastname: Da Silva
mesh_terms: D015308:Anaerobic Threshold; D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D005081:Exercise Therapy; D017079:Exercise Tolerance; D000072696:High-Intensity Interval Training; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol