title: Elevated serum brain natriuretic peptide and matrix metalloproteinases 2 and 9 in Wilson's disease.
abstract: Wilson's disease (WD) is a disease of copper metabolism characterized by excessive copper deposition in the body. It is reported abnormal copper metabolism has been associated with cardiovascular disease. BNP and MMP2/9 were biomarkers of congestive heart failure (CHF). There is rare study to explore whether serum concentrations of BNP, MMP2, and or MMP9 are altered in patients with WD. In this study we determine whether serum concentrations of brain natriuretic peptide (BNP) and matrix metalloproteinases (MMP) 2 and 9 are increased in patients with WD. Serum BNP, MMP2 and MMP9 were measured by an ELISA in 34 patients with hepatic WD, in 68 patients with neurological WD, and in 33 healthy controls. We found serum BNP levels were higher in patients with neurological WD than in healthy controls (p = 0.033). Serum MMP2 levels were higher in patients with hepatic (p = 0.009) and neurologic (p = 0.0004) WD than in controls. Serum MMP9 levels were higher in patients with neurologic WD than in patients with hepatic WD (p = 0.002) and controls (p = 0.00005), and were higher in patients with hepatic WD than in controls (p = 0.03). Serum BNP levels were negatively correlated with ceruloplasmin (p = 0.017, r = -0.215), while serum (p = 0.019, r = -0.221) and MMP9 (p = 0.011, r = -0.231) in patients with WD were negatively correlated with ceruloplasmin. BNP, MMP2, and MMP9 may reflect the deposition of copper in the heart.
authors.affiliation: Wilson Disease Centre, Hospital Affiliated to Anhui Chinese Medical University, No. 357, Changjiangzhong Road, Hefei, Anhui, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Cheng
authors.forename: Honghao
authors.initials: H
authors.lastname: Wang
authors.forename: Jianjian
authors.initials: J
authors.lastname: Dong
authors.forename: Suyue
authors.initials: S
authors.lastname: Pan
authors.forename: Xun
authors.initials: X
authors.lastname: Wang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Han
authors.forename: Yongzhu
authors.initials: Y
authors.lastname: Han
authors.forename: Renmin
authors.initials: R
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006527:Hepatolenticular Degeneration / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood*; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9