title: Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity.
abstract: By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophore models were proposed based on the obtained results and 3D QSAR modelling. Cytotoxic effects against mainly human immortalised and normal cell lines of different origin (malignant melanoma MeWo, colorectal adenocarcinoma HT29, promyelocytic leukemia HL60, gingival fibroblasts HFIG, skin keratinocytes HaCaT and rat small intestine epithelium IEC6) were examined. The odour descriptions of newly synthesised compounds are given.
authors.affiliation: Institute of General Food Chemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland. radoslaw.bonikowski@p.lodz.pl.
authors.forename: Radosław
authors.initials: R
authors.lastname: Bonikowski
authors.affiliation: Institute of General Food Chemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland. paulina@toya.net.pl.
authors.forename: Paulina
authors.initials: P
authors.lastname: Świtakowska
authors.affiliation: Environmental Biology Department, Medical University of Łódź, Żeligowskiego St. 7/9, 90-752 Łódź, Poland. monika.sienkiewicz@umed.lodz.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Sienkiewicz
authors.affiliation: Institute of Technical Biochemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland. malgorzata.zaklos-szyda@p.lodz.pl.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Zakłos-Szyda
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D054830:Sesterterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D054830:Sesterterpenes
keywords: antimicrobial activity; cytotoxicity; farnesol; farnesyl acetate; geranyl acetone; nerolidol; structurally related compound; terpenoids