title: Role of membrane biophysics in Alzheimer's-related cell pathways.
abstract: Cellular membrane alterations are commonly observed in many diseases, including Alzheimer's disease (AD). Membrane biophysical properties, such as membrane molecular order, membrane fluidity, organization of lipid rafts, and adhesion between membrane and cytoskeleton, play an important role in various cellular activities and functions. While membrane biophysics impacts a broad range of cellular pathways, this review addresses the role of membrane biophysics in amyloid-β peptide aggregation, Aβ-induced oxidative pathways, amyloid precursor protein processing, and cerebral endothelial functions in AD. Understanding the mechanism(s) underlying the effects of cell membrane properties on cellular processes should shed light on the development of new preventive and therapeutic strategies for this devastating disease.
authors.affiliation: Department of Chemical, Biological and Bioengineering, North Carolina A&T State University Greensboro, NC, USA.
authors.forename: Donghui
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Indiana University School of Medicine Medical Scientist Training Program, Indiana University School of Medicine Indianapolis, IN, USA.
authors.forename: Brittani L
authors.initials: BL
authors.lastname: Bungart
authors.affiliation: Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg Gothenburg, Sweden ; The Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine St. Louis, MO, USA.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Bioengineering and Regenerative Medicine, Center for Life Sciences, Nazarbayev University Astana, Kazakhstan.
authors.forename: Zhaxybay
authors.initials: Z
authors.lastname: Zhumadilov
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago Chicago, IL, USA.
authors.forename: James C-M
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Department of Bioengineering and Regenerative Medicine, Center for Life Sciences, Nazarbayev University Astana, Kazakhstan.
authors.forename: Sholpan
authors.initials: S
authors.lastname: Askarova
keywords: amyloid precursor protein; amyloid-β peptide; cerebral endothelium; membrane fluidity; membrane molecular order