title: Maternal Alcohol Consumption during Pregnancy and Early Age Leukemia Risk in Brazil.
abstract: Objectives. To investigate the association between the maternal alcohol consumption during pregnancy and early age leukemia (EAL) in offspring. Methods. Datasets were analyzed from a case-control study carried out in Brazil during 1999-2007. Data were obtained by maternal interviews using a standardized questionnaire. The present study included 675 children (193 acute lymphoid leukemia (ALL), 59 acute myeloid leukemia (AML), and 423 controls). Unconditional logistic regression was performed, and adjusted odds ratios (adj. OR) on the association between alcohol consumption and EAL were ascertained. Results. Alcohol consumption was reported by 43% of ALL and 39% of AML case mothers and 35.5% of controls'. Beer consumption before and during pregnancy was associated with ALL in crude analysis (OR = 1.54, 95% CI, 1.08-2.19), although in adjusted analysis no statistical significance was found. For weekly intake of ≤1 glass (adj. OR = 1.30, 95% CI, 0.71-2.36) and ≥1 glass/week (adj. OR = 1.47, 95% CI, 0.88-2.46) a potential dose-response was observed (P trend < 0.03). Conclusion. This study failed to support the hypothesis of an increased risk of EAL associated with maternal alcohol intake during pregnancy, neither with the interaction with tobacco nor with alcohol consumption.
authors.affiliation: Environment and Public Health Postgraduation Program, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Rua Leopoldo Bulhões 1480, 21041-210 Rio de Janeiro, RJ, Brazil.
authors.forename: Jeniffer Dantas
authors.initials: JD
authors.lastname: Ferreira
authors.affiliation: State University Center of the West Zone (UEZO), Rua Manuel Caldeira de Alvarenga 1203, 23070-200 Rio de Janeiro, RJ, Brazil.
authors.forename: Arnaldo Cézar
authors.initials: AC
authors.lastname: Couto
authors.affiliation: Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer (INCA), Rua André Cavalcanti 37, 20231-050 Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana
authors.identifier: 0000-0003-2337-8420
authors.initials: M
authors.lastname: Emerenciano
authors.affiliation: Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer (INCA), Rua André Cavalcanti 37, 20231-050 Rio de Janeiro, RJ, Brazil.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Pombo-de-Oliveira
authors.affiliation: Environment and Public Health Postgraduation Program, National School of Public Health, Oswaldo Cruz Foundation (FIOCRUZ), Rua Leopoldo Bulhões 1480, 21041-210 Rio de Janeiro, RJ, Brazil.
authors.forename: Sergio
authors.initials: S
authors.lastname: Koifman
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000503:physiopathology; D001938:Brazil; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D018811:Maternal Exposure; D009035:Mothers; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors