title: Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis.
abstract: We describe a 61-year-old woman with acute kidney injury, nephrotic range proteinuria and hematuria. Kidney biopsy showed membranous glomerulopathy (MG) with superimposed pauci-immune necrotizing crescentic glomerulonephritis (PNCGN). Coexistent MG and PNCGN is a rare occurrence. The diagnosis of such an exceptionally rare combination relies on the combination of renal biopsy findings and serologic testing. We also review previous reported cases and discuss possible pathogenesis of this rare dual glomerulopathy.
authors.affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.
authors.forename: Huma
authors.initials: H
authors.lastname: Fatima
authors.affiliation: Division of Nephrology and Hypertension , Vanderbilt University Medical Center , Nashville, TN , USA.
authors.forename: Edward D
authors.initials: ED
authors.lastname: Siew
authors.affiliation: Division of Nephrology and Hypertension , Vanderbilt University Medical Center , Nashville, TN , USA.
authors.forename: Jamie P
authors.initials: JP
authors.lastname: Dwyer
authors.affiliation: Department of Pathology, Microbiology and Immunology (MCN C2318B) , Vanderbilt University Medical Center , Nashville, TN , USA.
authors.forename: Paisit
authors.initials: P
authors.lastname: Paueksakon
keywords: anti-glomerular basement membrane disease; antineutrophil cytoplasmic antibodies; membranous glomerulopathy; pauci-immune necrotizing crescentic glomerulonephritis