title: Challenging diagnosis and treatment of HIT in child with ventricular assistance device.
abstract: HIT presents the clinician with unique diagnostic challenges, especially in the pediatric population. The HIT clinical sequelae of thrombocytopenia and thrombosis are secondary to the activation of platelets by heparin-antibody complexes. Diagnosis involves clinical observations and confirmatory laboratory testing using antibody detection and the functional SRA. As we describe in the following case of a six-yr-old female, the SRA may be difficult to interpret in the case of high-titer antibodies and illustrates the need for repeat testing in cases of high clinical suspicion.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Weintraub
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Driscoll
authors.affiliation: Division of Cardiology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Division of Cardiology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Jaqueline M
authors.initials: JM
authors.lastname: Lamour
authors.affiliation: Department of Cardiovascular and Thoracic Surgery, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Weinstein
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: Deepa
authors.initials: D
authors.lastname: Manwani
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D002648:Child; D005260:Female; D006353:Heart-Assist Devices; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D000925:Anticoagulants; D006493:Heparin
keywords: heparin-induced thrombocytopenia; serotonin release assay