title: Turkish version of the Drug Hypersensitivity Quality of Life Questionnaire: assessment of reliability and validity.
abstract: OBJECTIVE
  The first disease-specific quality-of-life questionnaire in patients with drug hypersensitivity, Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q), was developed and validated recently. The aim of this study was to assess validity, reliability and responsiveness to interventions of the Turkish version of the DrHy-Q.
  
  
  METHODS
  The Turkish version of the DrHy-Q was administered to prospectively enrolled 736 patients with drug hypersensitivity from ten allergy units. To assess validity, all patients completed the validated Turkish version of Psychological General Well-Being Index (PGWBI). For test-retest reliability, 182 patients completed the DrHy-Q 1 week after the first questionnaire administration without any intervention. Responsiveness was assessed on 97 patients who had a DrHy-Q recorded at a follow-up visit after the intervention.
  
  
  RESULTS
  The internal consistency and test-retest reliability of the scale were adequate (Cronbach's alpha = 0.934, intra-class correlation coefficient = 0.783). The DrHy-Q scores showed weak negative correlations with the PGWBI total and domain scores (r = - 0.378 to -0.254, p < 0.001). DrHy-Q was able to discriminate the patients with one drug hypersensitivity reaction from the patients with two and above two reactions (p = 0.012 and p < 0.001, respectively), and the patients who experienced a respiratory reaction from the patients who did not (p = 0.018). However, it did not discriminate the patients with comorbid disease including psychiatric comorbidity (p > 0.05). The baseline DrHy-Q scores were significantly higher than the post-intervention scores (p = 0.008).
  
  
  CONCLUSIONS
  The Turkish version of DrHy-Q is reliable and valid for evaluating quality of life in patients with drug hypersensitivity, and it appeared responsive to interventions.
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey. sevim.bavbek@medicine.ankara.edu.tr.
authors.forename: Sevim
authors.initials: S
authors.lastname: Bavbek
authors.affiliation: Department of Internal Medicine, Division of Allergy and Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.
authors.forename: Seçil
authors.initials: S
authors.lastname: Kepil Özdemir
authors.affiliation: Department of Biostatistics, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Beyza
authors.initials: B
authors.lastname: Doğanay Erdoğan
authors.affiliation: Department of Psychiatry, Ankara University School of Medicine, Ankara, Turkey.
authors.forename: Işıl
authors.initials: I
authors.lastname: Karaboğa
authors.affiliation: Department of Internal Medicine, Division of Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Büyüköztürk
authors.affiliation: Department of Internal Medicine, Division of Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Gelincik
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: İnsu
authors.initials: İ
authors.lastname: Yılmaz
authors.affiliation: Department of Pulmonary Medicine, Asthma and Allergy Unit, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Göksel
authors.affiliation: Department of Internal Medicine, Division of Allergy and Immunology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.
authors.forename: Adile Berna
authors.initials: AB
authors.lastname: Dursun
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: Gül
authors.initials: G
authors.lastname: Karakaya
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Kalyoncu
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ferhan
authors.initials: F
authors.lastname: Özşeker
authors.affiliation: , İstanbul, Turkey.
authors.forename: Gülden
authors.initials: G
authors.lastname: Paşaoğlu Karakış
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Ferda
authors.initials: F
authors.lastname: Öner Erkekol
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Köycü
authors.affiliation: Department of Chest Diseases, Division of Allergy and Immunology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Keren
authors.affiliation: Allergy and Respiratory Diseases Clinic - DIMI, University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Baiardini
authors.affiliation: Allergy Unit, Complesso Integrato Columbus, Rome, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Romano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014177:Translations; D014421:Turkey; D055815:Young Adult
keywords: Disease-specific questionnaires; Drug allergy; Drug hypersensitivity; Quality of life