title: Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis.
abstract: In this paper, the use of clarithromycin lactobionate, a kind of antibiotic chiral selector, in combination with four neutral cyclodextrin derivatives (glucose-β-cyclodextrin, hydroxyethyl-β-cyclodextrin, methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin) was reported for the first time. As a result, these dual systems gave much better resolution of nefopam (the Rs increased to 3.58, 2.72, 1.49 and 1.42, respectively) compared to the single systems. The effects of buffer pH and selector concentration on the separation of nefopam were also investigated. Additionally, some other basic drugs including metoprolol, atenolol, propranolol, bisoprolol, esmolol and ritodrine were tested for the investigation and evaluation of the enantiorecognition capability of the four dual systems. As expected, the synergistic effect was observed in four systems. Different results of these dual systems were also summarized.
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, Nanjing, P. R. China.|State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Yingxiang
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Jiaquan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Guangfu
authors.initials: G
authors.lastname: Xu
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Jinjing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China.
authors.forename: Shuaijing
authors.initials: S
authors.lastname: Du
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Zijie
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, P. R. China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D017291:Clarithromycin / Q000737:chemistry / Q000302:isolation & purification*; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; C005608:lactobionic acid; D017291:Clarithromycin
keywords: Capillary electrophoresis; Clarithromycin lactobionate; Cyclodextrin; Dual chiral system; Enantioseparation