title: Treatment of liver alveococcosis with high-intensity focused ultrasound.
abstract: This study evaluates the feasibility of using high intensity focused ultrasound (HIFU) for the treatment of liver alveococcosis. HIFU ablation was carried out in 36 patients with alveococcosis of the liver. The median age of patients was 39.24±12, 93 years (range: 20-66 years). The efficiency of treatment was monitored in real time with morphological evaluation, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US), and with morphological cytological and electron microscopy studies. HIFU ablation has shown effectiveness in destroying the protoscolexes, laminar and cell elements of the cuticular and germinal membrane of the alveococcosis larvocyst, causing the death of the cells of initial metamorphosis of alveococcosis, which is responsible for the dissemination of the parasite in the liver. Therefore HIFU-therapy is a promising and effective treatment for liver alveococcosis.
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan. Electronic address: Sikon_24@mail.ru.
authors.forename: S B
authors.initials: SB
authors.lastname: Imankulov
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan.
authors.forename: G V
authors.initials: GV
authors.lastname: Fedotovskikh
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan.
authors.forename: N K
authors.initials: NK
authors.lastname: Zhampeissov
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan.
authors.forename: M
authors.initials: M
authors.lastname: Yerlan
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan.
authors.forename: G M
authors.initials: GM
authors.lastname: Shaimardanova
authors.affiliation: The Joint Stock Company "National Scientific Medical Research Center", 42, Ablay Khan Avenue, Astana 010009, Kazakhstan.
authors.forename: L V
authors.initials: LV
authors.lastname: Knaub
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D008109:Liver Diseases, Parasitic / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D055815:Young Adult
keywords: HIFU; High intensity focused ultrasound; Liver alveococcosis