title: Amphiphilic sugar poly(orthoesters) as pH-responsive nanoscopic assemblies for acidity-enhanced drug delivery and cell killing.
abstract: A sugar poly(orthoester)-based drug delivery system was constructed to achieve acidity-enhanced drug delivery and cell killing.
authors.affiliation: Department of Chemistry and Biochemistry, Science of Advanced Materials, Central Michigan University, Mount Pleasant, MI 48859, USA. du1w@cmich.edu.
authors.forename: Lingyao
authors.initials: L
authors.lastname: Li
authors.forename: Kyle
authors.initials: K
authors.lastname: Knickelbein
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Melissa
authors.initials: M
authors.lastname: Obrinske
authors.forename: Gene Zhengxin
authors.initials: GZ
authors.lastname: Ma
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
authors.forename: Lindsay
authors.initials: L
authors.lastname: Bitterman
authors.forename: Wenjun
authors.initials: W
authors.lastname: Du
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D049329:Nanostructures / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D004337:Drug Carriers; D011091:Polyesters; D004317:Doxorubicin