title: The efficacy of TachoComb on reducing postoperative complications after tonsillectomy in children.
abstract: OBJECTIVE
  A fibrinogen/thrombin-based collagen fleece (TachoComb) is a powerful topical hemostatic agent that has been widely used in various surgical specialties with a favorable outcome. The purpose of this study was to investigate the effect of TachoComb application on postoperative complications after tonsillectomy.
  
  
  METHODS
  A total of 1633 children had undergone tonsillectomy with or without adenoidectomy were included in this study. After removal of both tonsils, 1057 patients (64.7%) were treated with TachoComb on the tonsillectomy site and 576 without TachoComb. Post-tonsillectomy pain, hemorrhage rates, re-admission rates, and emergency surgery rates for post-tonsillectomy hemorrhage were evaluated between patients who received TachoComb and those who did not.
  
  
  RESULTS
  TachoComb treatment significantly reduced post-tonsillectomy pain and emergency surgery rates for post-tonsillectomy hemorrhage. However, postoperative hemorrhage rate and re-admission rates for post-tonsillectomy hemorrhage were not statistically significant between TachoComb treatment group and control group. No patients had complications or adverse reactions after TachoComb treatment.
  
  
  CONCLUSIONS
  The use of TachoComb after tonsillectomy significantly reduces pain and emergency surgery for severe post-tonsillectomy hemorrhage without an apparent adverse effect. Therefore, TachoComb may be a useful adjuvant in terms of efficacy and safety after tonsillectomy.
authors.affiliation: Department of Otorhinolaryngology Inje Universty Haeundae Paik Hospital, Busan, Republic of Korea.
authors.forename: Yong-Wan
authors.initials: YW
authors.lastname: Kim
authors.affiliation: Department of Hemato-oncology, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.
authors.forename: Myoung-Joo
authors.initials: MJ
authors.lastname: Kang
authors.affiliation: Department of Otorhinolaryngology, Busan St. Mary's Medical Center, Busan, Republic of Korea.
authors.forename: Hyung-Ju
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Otorhinolaryngology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
authors.forename: Chang-Ki
authors.initials: CK
authors.lastname: Woo
authors.affiliation: Department of Otorhinolaryngology, Busan St. Mary's Medical Center, Busan, Republic of Korea.
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Mun
authors.affiliation: Department of Otorhinolaryngology and Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea. Electronic address: choks@pusan.ac.kr.
authors.forename: Kyu-Sup
authors.initials: KS
authors.lastname: Cho
mesh_terms: D000233:Adenoidectomy; D000293:Adolescent; D007611:Aprotinin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D006488:Hemostasis, Surgical / Q000379:methods*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D012189:Retrospective Studies; D013917:Thrombin / Q000627:therapeutic use*; D014068:Tonsillectomy; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D006490:Hemostatics; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin
keywords: Postoperative hemorrhage; Postoperative pain; Tachocomb; Tonsillectomy