title: CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy.
abstract: Translation of nanoparticles (NPs) into clinical practice has been limited by toxic effects induced by nonspecific accumulation of NPs in healthy organs after systemic administration. The ideal NPs should accumulate in the target site, carry out their function, and then ultimately be eliminated from the body. Here, we show a single-compartment, multifunctional ultrasmall copper sulfide nanodot (CuS ND) that is rapidly cleared from the body. These CuS NDs have a hydrodynamic diameter of <6 nm, can efficiently absorb near-infrared light for photothermal ablation therapy, and stably incorporate the copper-64 radioisotope for noninvasive positron emission tomography (PET). Importantly, ∼95% of CuS NDs are excreted intact through the renal-urinary system within 24 h with minimal retention in the liver and the spleen. The ultrasmall CuS NDs accumulate in 4T1 tumors in Balb/c mice, as monitored by PET imaging, and mediate tumor ablation when combined with near-infrared light irradiation. As a first example of PET-visible, renal-clearable inorganic nanomaterials with peak absorption in the near-infrared region, CuS NDs represent a robust platform for cancer imaging and therapy.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.forename: Su
authors.initials: S
authors.lastname: Liang
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.affiliation: ⊥Department of Pharmaceutical Sciences, Texas Southern University, Houston, Texas 77004, United States.
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
authors.forename: Chun
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D003301:Copper Radioisotopes / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000009:adverse effects* / Q000737:chemistry; D010789:Phototherapy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics*; D065667:Renal Elimination
chemical_list: D003301:Copper Radioisotopes; D019275:Radiopharmaceuticals
keywords: CuS nanodots; PET imaging; photothermal therapy; renal clearance; toxicity