title: Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.
abstract: The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Wen-Zhou
authors.initials: WZ
authors.lastname: Liu
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Nuo
authors.initials: N
authors.lastname: Yang
authors.affiliation: a Department of Cardio-Thoracic Surgery , The First Affiliated Hospital of GuangXi Medical University , Nanning , P.R. China.
authors.forename: Hua-Fu
authors.initials: HF
authors.lastname: Zhou
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases; D020928:Mitogen-Activated Protein Kinases
keywords: Extracellular signal-regulated kinase; mitogen-activated protein kinases; signaling pathway