title: Recent advances in understanding and managing cystic fibrosis transmembrane conductance regulator dysfunction.
abstract: Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians and has been extensively studied for many decades. The cystic fibrosis transmembrane conductance regulator gene was identified in 1989. It encodes a complex protein which has numerous cellular functions. Our understanding of cystic fibrosis pathophysiology and genetics is constantly expanding and being refined, leading to improved management of the disease and increased life expectancy in affected individuals.
authors.affiliation: Department of Gene Therapy and the UK Cystic Fibrosis Gene Therapy Consortium, Imperial College London SW3 6LR UK.
authors.forename: Uta
authors.initials: U
authors.lastname: Griesenbach
authors.affiliation: Department of Gene Therapy and the UK Cystic Fibrosis Gene Therapy Consortium, Imperial College London SW3 6LR UK.
authors.forename: Eric W F W
authors.initials: EW
authors.lastname: Alton