title: Particle Formation and Product Formulation Using Supercritical Fluids.
abstract: Traditional methods for solids processing involve either high temperatures, necessary for melting or viscosity reduction, or hazardous organic solvents. Owing to the negative impact of the solvents on the environment, especially on living organisms, intensive research has focused on new, sustainable methods for the processing of these substances. Applying supercritical fluids for particle formation may produce powders and composites with special characteristics. Several processes for formation and design of solid particles using dense gases have been studied intensively. The unique thermodynamic and fluid-dynamic properties of supercritical fluids can be used also for impregnation of solid particles or for the formation of solid powderous emulsions and particle coating, e.g., for formation of solids with unique properties for use in different applications. We give an overview of the application of sub- and supercritical fluids as green processing media for particle formation processes and present recent advances and trends in development.
authors.affiliation: Faculty of Chemistry and Chemical Engineering, University of Maribor, SI-2000 Maribor, Slovenia; email: zeljko.knez@um.si , masa.knez@um.si , mojca.skerget@um.si.
authors.forename: Željko
authors.initials: Ž
authors.lastname: Knez
authors.forename: Maša
authors.initials: M
authors.lastname: Knez Hrnčič
authors.forename: Mojca
authors.initials: M
authors.lastname: Škerget
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D003460:Crystallization / Q000295:instrumentation / Q000379:methods; D004655:Emulsions / Q000737:chemistry*; D004867:Equipment Design; D005740:Gases / Q000737:chemistry; D055772:Green Chemistry Technology / Q000295:instrumentation / Q000379:methods*; D057446:Hydrodynamics; D011208:Powders / Q000737:chemistry*; D011312:Pressure; D013816:Thermodynamics
chemical_list: D004655:Emulsions; D005740:Gases; D011208:Powders
keywords: PGSS™; antisolvent processes; dense gases; micronization; rapid expansion; spray extraction