title: Assessment of Atmospheric Pressure Plasma Treatment for Implant Osseointegration.
abstract: This study assessed the osseointegrative effects of atmospheric pressure plasma (APP) surface treatment for implants in a canine model. Control surfaces were untreated textured titanium (Ti) and calcium phosphate (CaP). Experimental surfaces were their 80-second air-based APP-treated counterparts. Physicochemical characterization was performed to assess topography, surface energy, and chemical composition. One implant from each control and experimental group (four in total) was placed in one radius of each of the seven male beagles for three weeks, and one implant from each group was placed in the contralateral radius for six weeks. After sacrifice, bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) were assessed. X-ray photoelectron spectroscopy showed decreased surface levels of carbon and increased Ti and oxygen, and calcium and oxygen, posttreatment for Ti and CaP surfaces, respectively. There was a significant (P < 0.001) increase in BIC for APP-treated textured Ti surfaces at six weeks but not at three weeks or for CaP surfaces. There were no significant (P = 0.57) differences for BAFO between treated and untreated surfaces for either material at either time point. This suggests that air-based APP surface treatment may improve osseointegration of textured Ti surfaces but not CaP surfaces. Studies optimizing APP parameters and applications are warranted.
authors.affiliation: Department of Biomaterials and Biomimetics, New York University, 345 East 24th Street, Room 804 S, New York, NY 10010, USA.
authors.forename: Natalie R
authors.initials: NR
authors.lastname: Danna
authors.affiliation: Department of Biomaterials and Biomimetics, New York University, 345 East 24th Street, Room 804 S, New York, NY 10010, USA.
authors.forename: Bryan G
authors.initials: BG
authors.lastname: Beutel
authors.affiliation: Department of Biomaterials and Biomimetics, New York University, 345 East 24th Street, Room 804 S, New York, NY 10010, USA.
authors.forename: Nick
authors.initials: N
authors.lastname: Tovar
authors.affiliation: School of Chemical Engineering, Oklahoma State University, 423 Engineering North, Stillwater, OK 74078, USA.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Witek
authors.affiliation: Department of Prosthodontics, University of São Paulo Bauru College of Dentistry, Al Otávio Pinheiro Brisola 9-75, 17012-901 Bauru, SP, Brazil.
authors.forename: Charles
authors.initials: C
authors.lastname: Marin
authors.affiliation: Department of Prosthodontics, University of São Paulo Bauru College of Dentistry, Al Otávio Pinheiro Brisola 9-75, 17012-901 Bauru, SP, Brazil.
authors.forename: Estevam A
authors.identifier: 0000-0001-6867-8350
authors.initials: EA
authors.lastname: Bonfante
authors.affiliation: Department of Prosthodontics, University of São Paulo Bauru College of Dentistry, Al Otávio Pinheiro Brisola 9-75, 17012-901 Bauru, SP, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Granato
authors.affiliation: Department of Prosthodontics, Tufts University School of Dental Medicine, 1 Kneeland Street, Boston, MA 02111, USA.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Biomaterials and Biomimetics, New York University, 345 East 24th Street, Room 804 S, New York, NY 10010, USA ; Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, USA ; Division of Engineering, New York University Abu Dhabi, Abu Dhabi, UAE.
authors.forename: Paulo G
authors.initials: PG
authors.lastname: Coelho
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D015921:Dental Implants; D004285:Dogs; D006801:Humans; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; C020243:calcium phosphate; D014025:Titanium