title: A unifying experimental design for dissecting tree genomes.
abstract: Linkage mapping and association mapping are adopted as an approach of choice for dissecting complex traits, but each shows a limitation when used alone. We propose an open-pollinated (OP) family design to integrate these two approaches into an organizing framework. The design unifies the strengths of population and quantitative genetic studies for evolutionary inference and high-resolution gene mapping. It particularly suits genome dissection of forest trees given their extant populations that are mostly undomesticated.
authors.affiliation: Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, and College of Landscape Architecture, Beijing Forestry University, Beijing 100083, China.
authors.forename: Lidan
authors.initials: L
authors.lastname: Sun
authors.affiliation: Center for Computational Biology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Xuli
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment, and College of Landscape Architecture, Beijing Forestry University, Beijing 100083, China.
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Center for Computational Biology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China; Center for Statistical Genetics, Pennsylvania State University, Hershey, PA 17033, USA. Electronic address: rwu@bjfu.edu.cn.
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D002874:Chromosome Mapping; D018745:Genome, Plant / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D014197:Trees / Q000235:genetics*