title: Aspergillus arthritis and organ transplantation.
abstract: We report a case of a kidney and pancreas transplanted patient, hospitalized for septic hip arthritis. The whole diagnostic work-up including synovial and bone biopsies remained negative. After inefficient empirical anti-bacterial antibiotic treatment, femoral head resection was performed and tissue analysis revealed Aspergillus fumigatus hyphae. Treatment with voriconazole along with hip replacement led to complete recovery. However, drug interaction between immunosuppressive and anti-fungal drugs was complicated by cellular acute graft rejection. Aspergillus fumigatus arthritis is an uncommon and serious infection that should be evoked especially in the case of resistance to anti-microbial antibiotics and/or an atypical clinical picture.
authors.affiliation: Institut of Transplantation - Urology - Nephrology (ITUN), Hôtel Dieu. CHU de Nantes, France.
authors.forename: Marie-Lucile
authors.initials: ML
authors.lastname: Figuères
authors.affiliation: Institut of Transplantation - Urology - Nephrology (ITUN), Hôtel Dieu. CHU de Nantes, France ; UMR INSERM 1024. Nantes, France.
authors.forename: Diego
authors.initials: D
authors.lastname: Cantarovich
authors.affiliation: Service de Maladies Infectieuses, Hôpital Pontchaillou. CHU de Rennes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Tattevin
authors.affiliation: Service de Néphrologie, Hôpital Pontchaillou. CHU de Rennes, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Le Pogamp
authors.affiliation: Service de Chirurgie Orthopédique, Hôpital Pontchaillou. CHU de Rennes, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Polard
authors.affiliation: Service d'Anatomopathologie, Hôpital Pontchaillou. CHU de Rennes, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Stock
authors.affiliation: Institut of Transplantation - Urology - Nephrology (ITUN), Hôtel Dieu. CHU de Nantes, France ; UMR INSERM 1024. Nantes, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Blancho
keywords: Aspergillus fumigatus; arthritis; immunosuppression; transplant infectious diseases