title: Modulatory effect of diphenyl diselenide in Carioca High- and Low-conditioned Freezing rats.
abstract: Diphenyl diselenide ([PhSe]2)is an organoselenium compound that has interesting pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. The objective of the present study was to investigate the possible modulatory effect of (PhSe)2 in 17th-generation Carioca high-and low-conditioned freezing (CHF and CLF) rats, an animal model of generalized anxiety disorders. (PhSe)2 was administered at three doses (10, 50, and 100mg/kg) in CHF and CLF rats, and their anxiety-like profiles (conditioned freezing patterns) were measured before and 30min after treatment. A significant difference was found in freezing scores between CHF and CLF animals before treatment (t70=12.50, p<0.001). Treatment with (PhSe)2 at 10 and 50mg/kg decreased freezing in CHF rats but significantly increased freezing at 100mg/kg. (PhSe)2 increased freezing in CLF animals at 50 and 100mg/kg (p<0.01). These results indicate that (PhSe)2 exerts both anxiolytic- and anxiogenic-like effects in bi-directional rat lines. Distinct genetic profiles of the CHF and CLF lines may influence biochemical functions and lead to differential responses to aversive situations and various drugs like (PhSe)2.
authors.affiliation: Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Institute of Chemical Sciences, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, 25120, Pakistan.
authors.forename: Waseem
authors.initials: W
authors.lastname: Hassan
authors.affiliation: Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Carlos Eduardo Barroso
authors.initials: CE
authors.lastname: Silva
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e E xatas, Universidade Federal de Santa Maria, Santa Maria, RS CEP 97105-900, Brazil.
authors.forename: Joao Batista Teixeira da
authors.initials: JB
authors.lastname: Rocha
authors.affiliation: Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: landeira@puc-rio.br.
authors.forename: J
authors.initials: J
authors.lastname: Landeira-Fernandez
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000633:toxicity; D001008:Anxiety Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D001522:Behavior, Animal / Q000187:drug effects*; D001555:Benzene Derivatives / Q000494:pharmacology* / Q000633:toxicity; D003213:Conditioning, Psychological / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005239:Fear; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects*; D016566:Organoselenium Compounds / Q000494:pharmacology* / Q000633:toxicity; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001555:Benzene Derivatives; D016566:Organoselenium Compounds; C061132:diphenyldiselenide
keywords: Anxiety; Breading line; Contextual fear conditioning; Diphenyl diselenide; Freezing