title: The Role of Psychological Distress in Relapse Prevention of Alcohol Addiction. Can High Scores on the SCL-90-R Predict Alcohol Relapse?
abstract: OBJECTIVE
  The aim of this study was to identify if psychological distress may contribute to treatment outcome in alcohol-addicted patients during a follow-up period of 5 months after detoxification.
  
  
  METHODS
  As part of a prospective, multicenter, randomized study in relapse prevention, patients' levels of psychological distress were assessed using the Symptome Checklist (SCL-90-R). At study inclusion, all patients were detoxified and showed no more withdrawal symptoms. The patients who relapsed during the 5-month follow-up period were compared with those who remained abstinent. Predictors for relapse were investigated in a logistic regression.
  
  
  RESULTS
  First, a significant difference in initial psychological distress between patients who stayed abstinent and patients who relapsed was found: following detoxification, patients who relapsed scored significantly higher on the SCL-90-R at study inclusion. In addition, psychological distress differed over time in both groups. Second, patients without relapse showed a larger decrease in some SCL-90-R scales between the beginning and the end of the observation period than patients who relapsed. Third, the logistic regression analyses showed that high scores on the overall score GSI (Global Severity Index) of the SCL-90-R can be seen as a predictor for future relapse.
  
  
  CONCLUSIONS
  The SCL-90-R may be a useful instrument to predict relapse. As our study indicates that high levels of psychological distress increases the risk of relapse, specific interventions may be targeted at this risk factor.
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus-Mitte, Berlin, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Engel
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus-Mitte, Berlin, Germany Department of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, Essen, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Schaefer
authors.affiliation: Charité Comprehensive Cancer Center, Charité Campus-Mitte, Berlin, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Stickel
authors.affiliation: Oberbaumstrasse 7, Berlin 10997, Germany.
authors.forename: Hennriette
authors.initials: H
authors.lastname: Binder
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus-Mitte, Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus-Mitte, Berlin, Germany Department of Psychiatry, Psychotherapy, Psychosomatic/Gerontopsychiatry, Vivantes, Wenckebach-Hospital, Berlin, Germany christoph.richter@vivantes.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Richter
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000517:prevention & control / Q000523:psychology / Q000534:rehabilitation*; D001007:Anxiety / Q000523:psychology*; D003863:Depression / Q000523:psychology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012306:Risk; D055502:Secondary Prevention; D013315:Stress, Psychological / Q000523:psychology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome