title: Abdominal Obesity Associated with Elevated Serum Butyrylcholinesterase Activity, Insulin Resistance and Reduced High Density Lipoprotein-Cholesterol Levels.
abstract: Abdominal obesity (AO) has a strong correlation with cardiovascular disease and has been linked to Alzheimer's disease and type 2 diabetes. We investigated the association between AO and elevated serum butyrylcholinesterase (BChE) activity, insulin resistance and the serum lipid profile, including triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels in AO and non-AO women subjects. A total of 500 AO subjects (age 49.1 ± 10.5 years), and 142 non-AO women subjects (age 49.9 ± 11.9 years) were enrolled for the general biochemistry tests, serum BChE, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Body mass index, waist circumference, Blood pressure (BP), plasma glucose (Glu), triglyceride (TG), BChE, insulin, HOMA-IR were significantly higher and HDL-C levels were significantly lower in AO subjects (p < 0.05). Waist circumference was significantly correlated with BP, Glu, TG, BChE, insulin and HOMA-IR in AO subjects. Multiple logistic regression demonstrated that AO was associated with elevated BChE, HOMA-IR, hypertension and reduced HDL-C after adjusting for these variables. AO is associated with elevated BChE, insulin resistance, HT and reduced HDL-C. These may predict the development of type 2 diabetes mellitus and may be associated with cognitive disorder in the future, both are mediated through insulin resistance.
authors.affiliation: Chronic Diseases Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand ; Chronic Diseases Research Unit, Department of Optometry, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand.
authors.forename: Surapon
authors.initials: S
authors.lastname: Tangvarasittichai
authors.affiliation: SaiNgam District Public Health Office, Ministry of Public Health, Kumpangphet, 62150 Thailand.
authors.forename: Suthap
authors.initials: S
authors.lastname: Pongthaisong
authors.affiliation: Allied Health Sciences Health Promotion Centre, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand.
authors.forename: Suwadee
authors.initials: S
authors.lastname: Meemark
authors.affiliation: Chronic Diseases Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand.
authors.forename: Orathai
authors.initials: O
authors.lastname: Tangvarasittichai
keywords: Abdominal obesity; Butyrylcholinesterase; High density lipoprotein-cholesterol; Insulin resistance