title: Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-Fed Rats Through Inhibition of TLR4/MyD88 Signaling.
abstract: Accumulating evidence indicates that overconsumption of ethanol contributes in many ways to the pathogenesis of hepatic injury. Although studies indicate that taurine decreases lipogenesis, oxidative stress, and inflammatory cytokines, the protective effect of taurine against alcohol-induced liver injury is still unclear. To clarify the precise signaling involved in the beneficial effect of taurine on alcohol-induced liver injury, rats were randomly divided into four treatment groups: (1) control (Ctl), (2) alcohol (Alc), (3) Alc+taurine (Tau), and (4) Alc+silymarin (Sil). The Tau and Sil groups had lower lymphocyte infiltration and significantly lower TLR-4/MyD88 and IκB/NFκB compared to the Alc group. The inducible nitric oxide synthase (iNOS), C-reactive protein (CRP), tumor necrosis factors (TNF)-α, interleukin (IL)-6, and IL-1β were also significantly lower in the Tau and Sil groups than in the Alc group. The experimental results indicated that hepatoprotection against alcohol-induced inflammation may be mediated by decreased TLR-4/MyD88 signaling.
authors.affiliation: 1 Department of Pediatrics, Changhua Christian Hospital , Changhua, Taiwan .
authors.forename: Chao-Jen
authors.initials: CJ
authors.lastname: Lin
authors.affiliation: 2 Institute of Microbiology and Immunology, School of Medicine, Chung Shan Medical University , Taichung, Taiwan .|3 Department of Neurology, Changhua Christian Hospital , Changhua, Taiwan .|4 Department of Medical Intensive Care Unit, Changhua Christian Hospital , Changhua, Taiwan .
authors.forename: Chun-Ching
authors.initials: CC
authors.lastname: Chiu
authors.affiliation: 5 Department of Animal Science and Technology, National Taiwan University , Taipei, Taiwan .
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Chen
authors.affiliation: 6 Institute of Biochemistry and Biotechnology, School of Medicine, Chung Shan Medical University , Taichung, Taiwan .
authors.forename: Mu-Lin
authors.initials: ML
authors.lastname: Chen
authors.affiliation: 2 Institute of Microbiology and Immunology, School of Medicine, Chung Shan Medical University , Taichung, Taiwan .|7 Clinical Laboratory, Chung Shan Medical University Hospital , Taichung, Taiwan .
authors.forename: Tsai-Ching
authors.initials: TC
authors.lastname: Hsu
authors.affiliation: 6 Institute of Biochemistry and Biotechnology, School of Medicine, Chung Shan Medical University , Taichung, Taiwan .|7 Clinical Laboratory, Chung Shan Medical University Hospital , Taichung, Taiwan .|8 Department of Biochemistry, School of Medicine, Chung Shan Medical University , Taichung, Taiwan .
authors.forename: Bor-Show
authors.initials: BS
authors.lastname: Tzang
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D000431:Ethanol / Q000009:adverse effects*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D007378:Interleukins / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D017208:Rats, Wistar; D015398:Signal Transduction; D012838:Silymarin / Q000494:pharmacology / Q000627:therapeutic use; D013654:Taurine / Q000494:pharmacology* / Q000627:therapeutic use; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D018836:Inflammation Mediators; D007378:Interleukins; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; D012838:Silymarin; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; D013654:Taurine; D000431:Ethanol; D002097:C-Reactive Protein; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat
keywords: chronic alcohol-fed rats; hepatic injury; inflammation; silymarin; taurine