title: Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics.
abstract: An innovative, microwell-based platform for single-cell RNA sequencing (RNA-seq) combines cost efficiency, scalability and parallelizability, and will enable many new avenues of biological inquiry.See related Research article: http://dx.doi.org/10.1186/s13059-015-0684-3.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.|Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.|Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02115, USA.
authors.forename: Marc H
authors.initials: MH
authors.lastname: Wadsworth
authors.affiliation: Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.|Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.|Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02115, USA.|Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA.
authors.forename: Travis K
authors.initials: TK
authors.lastname: Hughes
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.|Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. shalek@mit.edu.|Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. shalek@mit.edu.|Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02115, USA. shalek@mit.edu.|Division of Health Sciences and Technology, Harvard Medical School, Boston, MA, USA. shalek@mit.edu.|Immunology, MGH, Boston, MA, 02114, USA. shalek@mit.edu.
authors.forename: Alex K
authors.initials: AK
authors.lastname: Shalek
mesh_terms: D020869:Gene Expression Profiling / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods*