title: Platinum nanoparticles/graphene-oxide hybrid with excellent peroxidase-like activity and its application for cysteine detection.
abstract: A facile approach is proposed for the growth of platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting PtNPs/GO hybrid has been proved to function as peroxidase mimics that can catalyze the oxidation of peroxidase substrates in the presence of hydrogen peroxide (H2O2). Kinetic studies indicate that the PtNPs/GO nanocomposite has a considerably higher affinity for both 3,3',5,5'-tetramethylbenzidine (TMB) and H2O2 than those of other platinum-based peroxidase mimics. Furthermore, colorimetric recognition and sensing of L-cysteine with high sensitivity and selectivity is presented based on target-induced shielding against the peroxidase-like activity of PtNPs/GO. We envision that this material will be an ideal candidate for a wide range of potential applications in the fields of biomedicine and environmental chemistry.
authors.affiliation: Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China. chenandhu@163.com.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Lin
authors.forename: Hao-Hua
authors.initials: HH
authors.lastname: Deng
authors.forename: Gang-Wei
authors.initials: GW
authors.lastname: Wu
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Peng
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lin
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Xia
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D001560:Benzidines / Q000737:chemistry; D002384:Catalysis; D003124:Colorimetry / Q000379:methods; D003545:Cysteine / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D007700:Kinetics; D057230:Limit of Detection; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D009195:Peroxidase / Q000737:chemistry*
chemical_list: D001560:Benzidines; D010087:Oxides; C021758:3,3',5,5'-tetramethylbenzidine; D006108:Graphite; D006861:Hydrogen Peroxide; D009195:Peroxidase; D003545:Cysteine