title: Negative-Pressure Cavitation Extraction of Secoisolariciresinol Diglycoside from Flaxseed Cakes.
abstract: The negative-pressure cavitation extraction (NPCE) technique was applied firstly to extract secoisolariciresinol diglucoside (SDG) from flaxseed cakes. The significant extraction parameters were screened by fractional factorial design (FFD). The optimal parameters were determined using the central composite design (CCD) with the two variables, NaOH amount and the liquid/solid ratio. The conditions of the extraction were optimized by using response surface methodology (RSM). Under the optimal conditions, the extraction yield and the extraction purity of SDG was 16.25 mg/g and 3.86%, respectively. The efficiency of NPCE was compared with that of conventional extraction methods. Our results demonstrated that NPCE was comparable to the well-known ultrasound-assisted extraction in term of extraction yield and purity. This extraction technique has advantages of less time-consuming, low solvent usage and high throughput capability.
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. tianhao.630@163.com.|Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. tianhao.630@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Tian
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. wyli2012@126.com.
authors.forename: Wan-Yi
authors.initials: WY
authors.lastname: Li
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. xiaodanms@126.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.affiliation: Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650205, China. lzmyaas@163.com.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. bcjwwang@gmail.com.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Wang
mesh_terms: D002072:Butylene Glycols / Q000737:chemistry*; D005591:Chemical Fractionation / Q000379:methods; D019597:Flax / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D002072:Butylene Glycols; D005960:Glucosides; D010936:Plant Extracts; C090142:secoisolariciresinol diglucoside
keywords: flaxseed cake; negative-pressure cavitation extraction; pilot-scale application; response surface methodology; secoisolariciresinol diglucoside