title: BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma.
abstract: The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia.
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA; Department of Pathology, Gulhane Military Medical Academy and School of Medicine, Ankara, Turkey. Electronic address: nuy2001@med.cornell.edu.
authors.forename: Nuri
authors.initials: N
authors.lastname: Yigit
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Wu
authors.affiliation: Department of Pathology and Laboratory Medicine, Winthrop University Hospital, Mineola, NY, USA.
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Subramaniyam
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Mathew
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA.
authors.forename: Julia T
authors.initials: JT
authors.lastname: Geyer
mesh_terms: D002871:Chromosome Banding; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D059785:Karyotype; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr / Q000235:genetics*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D015514:Oncogene Proteins, Fusion; D020796:Receptor, Platelet-Derived Growth Factor alpha; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr
keywords: BCR gene; BCR-PDGFRA fusion; PDGFRA gene; T-ALL; t(4;22)(q12;q11.2)