title: Effect of Sodium Nitrite and L-NNA on the Outcome of Experimental Ischemic Stroke.
abstract: We studied the effect of sodium nitrite in doses of 5 and 50 mg/kg and NO synthase inhibitor L-NNA in a dose of 20 mg/kg on the course of experimental ischemic stroke caused by occlusion of both carotid arteries. Sodium nitrite and NO synthase inhibitor were administered 1 h prior to occlusion of еру carotid arteries and 5 sec after brain ischemia. Sodium nitrite in a dose of 5 mg/kg had a protective effect on the time course of neurological disorders and reduced animal mortality. NO synthase inhibitor L-NNA aggravated the neurological symptoms.
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia, kouzenkov@mail.ru.
authors.forename: V S
authors.initials: VS
authors.lastname: Kuzenkov
authors.forename: A L
authors.initials: AL
authors.lastname: Krushinskii
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008297:Male; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D020521:Stroke / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D019335:Nitroarginine; D019001:Nitric Oxide Synthase; D012977:Sodium Nitrite