title: Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri.
abstract: A 71-year-old immunocompetent man developed cognitive decline and gait disturbance. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without a mass lesion. An analysis of the cerebrospinal fluid (CSF) showed elevated levels of interleukin (IL)-10. The condition of the patient progressively deteriorated, and intravenous high-dose steroids proved ineffective. Detection of non-destructive, diffusely infiltrating, large B-cell lymphoma in biopsy and autopsy specimens led to a diagnosis of lymphomatosis cerebri (LC). On serial MRI, the basal ganglia and white matter lesions increased in parallel with the levels of IL-10. These findings suggest that the IL-10 level in the CSF may represent a potentially useful biomarker for the early diagnosis and monitoring of the disease progression in LC.
authors.affiliation: Department of Neurology, Yokohama City University Medical Center, Japan.
authors.forename: Shunta
authors.initials: S
authors.lastname: Hashiguchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Momoo
authors.forename: Yoko
authors.initials: Y
authors.lastname: Murohashi
authors.forename: Masanao
authors.initials: M
authors.lastname: Endo
authors.forename: Megumi
authors.initials: M
authors.lastname: Shimamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Sachie
authors.initials: S
authors.lastname: Kanada
authors.forename: Akinori
authors.initials: A
authors.lastname: Nozawa
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tada
authors.forename: Shigeru
authors.initials: S
authors.lastname: Koyano
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid*; D001706:Biopsy; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D020233:Gait Disorders, Neurologic / Q000134:cerebrospinal fluid* / Q000209:etiology; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid*; D016393:Lymphoma, B-Cell / Q000134:cerebrospinal fluid* / Q000150:complications / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D014408:Biomarkers, Tumor; D016753:Interleukin-10