title: [Prevalence study of the genetic markers associated with slow progression of human inmunodefiency virus type 1 in the Galician population (Northwest of Spain)].
abstract: BACKGROUND
  The deletion in the CCR5 gene (CCR5Δ32), the HLA-B*27:05, and polymorphisms rs2395029 and rs9264942 have been associated with slower progression of HIV-1.
  
  
  METHODS
  An analysis was performed on 408 patients on follow-up. The analysis of viral load, CD4+ Tlymphocytes and other clinical variables since the diagnosis of the infection were collected.
  
  
  RESULTS
  The prevalence of the genetic markers rs9264942, CCR5wt/Δ32, rs2395029, HLA-B*27:05 was 17.9%, 11.5%, 7.6%, and 6.4%, respectively. Of all the patients, 354 were classified as progressors and 46 as long-term non-progressors (LTNPs). Except for the HLA-B*27:05 allele, other genetic markers were associated with slower progression: CCR5wt/Δ32 (P=.011) and SNPs rs2395029 and rs9264942 (P<.0001), as well as their association (P<.0001).
  
  
  CONCLUSIONS
  The prevalence of the HLA-B*57:01 allele was higher than described nationally. No association could be found between the HLA-B*27:05 allele and the presence of slower disease progression.
authors.affiliation: Departamento de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Pontevedra, España.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Rodríguez-Da Silva
authors.affiliation: Servicio de Medicina Interna, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.
authors.forename: Celia
authors.initials: C
authors.lastname: Miralles
authors.affiliation: Servicio de Medicina Interna, Complejo Hospitalario Universitario de Vigo, Vigo, Pontevedra, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ocampo
authors.affiliation: Departamento de Bioquímica, Genética e Inmunología, Universidad de Vigo, Vigo, Pontevedra, España; Instituto de Investigación Biomédica de Vigo (IBIV), Hospital Meixoeiro, Vigo, Pontevedra, España. Electronic address: dianaval@uvigo.es.
authors.forename: Diana
authors.initials: D
authors.lastname: Valverde
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D013030:Spain; D013997:Time Factors; D055815:Young Adult
chemical_list: D005819:Genetic Markers
keywords: Disease progression; Genetic markers; Human immunodeficiency virus type 1; Long-term non-progressors; Marcadores genéticos; No progresores a largo plazo; Prevalence; Prevalencia; Progresión; Virus de la inmunodeficiencia humana tipo 1