title: Role of the pathologist in active surveillance for prostate cancer.
abstract: Active surveillance (AS) is an alternative strategy that aims to minimize overtreatment by selecting only patients with significant prostate cancer (PCa) tumors for immediate treatment. Patients with favorable tumor characteristics are closely monitored using serum prostate-specific antigen (PSA) levels and serial biopsies of the prostate. In addition, other predictors of tumor progression, such as PSA doubling time, can be used during AS management. AS represents an excellent opportunity to identify molecular biomarkers of PCa behavior and to develop novel therapeutic strategies.
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzucchelli
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Galosi
authors.forename: Matteo
authors.initials: M
authors.lastname: Santoni
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: Marina
authors.initials: M
authors.lastname: Scarpelli
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
mesh_terms: D001706:Biopsy; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010338:Pathology, Clinical / Q000379:methods*; D010820:Physicians; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis*; D012307:Risk Factors; D057832:Watchful Waiting
chemical_list: D017430:Prostate-Specific Antigen