title: Management of multicentric paragangliomas: Review of 24 patients with 60 tumors.
abstract: BACKGROUND
  The purpose of this study was to reflect our experience in the management of multicentric head and neck paragangliomas, including genetic study and counseling, diagnostic tools, types of treatment, and the need for monitoring.
  
  
  METHODS
  A retrospective review of 24 patients with multicentric paraganglioma, including a total of 60 paragangliomas: 37 carotid body tumors, 13 jugulotympanic paragangliomas, and 10 vagal paragangliomas.
  
  
  RESULTS
  A total of 26 surgical procedures were performed, including the resection of 36 paragangliomas. Four tumors were pending surgery at the time of this review. Radiotherapy was administered in 7 patients with 9 tumors. A "wait-and-scan" policy with periodic MRI imaging tests was instituted for 9 patients with 12 paragangliomas.
  
  
  CONCLUSIONS
  The knowledge of the different modalities of management is especially relevant in patients with multicentric paragangliomas. In every case, benefits and potential risks of all treatment options may be taken into consideration for every individual patient.
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Ricardo J González-Orús
authors.initials: RJ
authors.lastname: Álvarez-Morujo
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Miguel Ángel Arístegui
authors.initials: MÁ
authors.lastname: Ruiz
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Daniel Poletti
authors.initials: DP
authors.lastname: Serafini
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Irene López
authors.initials: IL
authors.lastname: Delgado
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Eviatar
authors.initials: E
authors.lastname: Friedlander
authors.affiliation: Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Bartolomé Scola
authors.initials: BS
authors.lastname: Yurrita
mesh_terms: D000328:Adult; D000368:Aged; D020209:Cranial Nerve Injuries / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010236:Paraganglioma, Extra-Adrenal / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies; D013385:Succinate Dehydrogenase / Q000235:genetics; D057832:Watchful Waiting / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: C491545:SDHD protein, human; D013385:Succinate Dehydrogenase
keywords: bilateral carotid body tumor; head and neck paraganglioma; hereditary paraganglioma; multicentric paraganglioma; multifocal glomus