title: Autoimmune polyglandular syndrome type 2 manifested as Hashimoto's thyroiditis and adrenocortical insufficiency, in Turner syndrome woman, with onset following introduction of treatment with recombinant human growth hormone.
abstract: Autoimmune polyglandular syndrome is a constellation of signs and symptoms of simultaneous insufficiencies of several endocrine glands. Autoimmune polyglandular syndrome type 2 (APS 2) may be diagnosed when the adrenocortical insufficiency is associated with an autoimmune thyroid disease (Hashimoto's thyroiditis or Graves' disease), and/or insulin-dependent diabetes mellitus. Turner syndrome is the most common chromosomal disorder in females, caused by complete or partial X chromosome monosomy. We present the case of a 20-year-old woman with Turner syndrome, in whom APS 2 (Hashimoto's thyroiditis and adrenocortical insufficiency) has been diagnosed after introduction of recombinant human growth hormone (rhGH) therapy. In Turner syndrome, examination of the patient must regularly be conducted in order to diagnose a possible onset of autoimmune diseases; respective treatment must be applied as soon as the diagnosis is established. In particular, therapy of rhGH, used for short stature treatment, may be a trigger factor of adrenal insufficiency. The cortisol level in blood should be assessed before rhGH administration and carefully monitored during the therapy, especially in case of autoimmune thyroid disease coexistence.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Cyniak-Magierska
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lasoń
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Smyczyńska
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewiński
mesh_terms: D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000328:Adult; D005260:Female; D050031:Hashimoto Disease / Q000139:chemically induced*; D019382:Human Growth Hormone / Q000009:adverse effects*; D006801:Humans; D016884:Polyendocrinopathies, Autoimmune / Q000139:chemically induced*; D014424:Turner Syndrome / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D019382:Human Growth Hormone