title: The Swedish CArdioPulmonary BioImage Study: objectives and design.
abstract: Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.|Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Bergström
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Berglund
authors.affiliation: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Blomberg
authors.affiliation: Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.|Department of Radiology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Brandberg
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Engström
authors.affiliation: Department of Clinical Physiology, County Council of Östergötland, Linköping, Sweden.|Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.|Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Engvall
authors.affiliation: Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Eriksson
authors.affiliation: Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.|Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: de Faire
authors.affiliation: Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.|Department of Radiology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Flinck
authors.affiliation: Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden.
authors.forename: M G
authors.initials: MG
authors.lastname: Hansson
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hedblad
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.|Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Hjelmgren
authors.affiliation: Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.affiliation: Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.|Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Jernberg
authors.affiliation: Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.|Department of Radiology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Å
authors.initials: Å
authors.lastname: Johnsson
authors.affiliation: Department of Radiology, Oncology and Radiation Science, Unit of Radiology, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Johansson
authors.affiliation: Department of Clinical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Lind
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.|Department of Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden.
authors.forename: C-G
authors.initials: CG
authors.lastname: Löfdahl
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.|Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Melander
authors.affiliation: Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
authors.forename: C J
authors.initials: CJ
authors.lastname: Östgren
authors.affiliation: Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.|Department of Radiology in Linkoping, County Council of Östergötland, Linköping, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Persson
authors.affiliation: Department of Clinical Sciences, Lund University, Lund, Sweden.|Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Persson
authors.affiliation: Department of Public Health and Clinical Medicine, Medicine and Heart Centre, Umeå University, Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sandström
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.affiliation: Department of Public Health and Clinical Medicine, Medicine and Heart Centre, Umeå University, Umeå, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Söderberg
authors.affiliation: Department of Clinical Sciences, Uppsala University, Uppsala, Sweden.|Uppsala Clinical Research Centre, Uppsala, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Sundström
authors.affiliation: Section of Occupational and Environmental Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Toren
authors.affiliation: Department of Public Health and Clinical Medicine Thoracic Center, Umeå University Hospital, Umeå University, Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Waldenström
authors.affiliation: Epidemiology and Biostatistics, Nordic School of Public Health, Gothenburg, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Wedel
authors.affiliation: Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.|Department of Radiology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Vikgren
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Fagerberg
authors.affiliation: Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Rosengren
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D040901:Proteomics / Q000379:methods; D011634:Public Health / Q000379:methods / Q000706:statistics & numerical data; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D012307:Risk Factors; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology
keywords: cardiovascular; epidemiology; metabolism; pulmonary; trial design