title: Organocatalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner.
abstract: A new method for the catalytic enantioselective formal arylation of azlactones using quinones as the aromatic partner was developed for the first time. Under mild conditions, the domino Michael/aromatization/cyclization reaction worked well to afford the corresponding products in moderate to high yields with excellent enantioselectivities, some of which have promising cytotoxicity against cancer cells and antibacterial activities.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. hongliang@sysu.edu.cn wangrui@lzu.edu.cn.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Li
authors.forename: Wangsheng
authors.initials: W
authors.lastname: Sun
authors.forename: Jingyi
authors.initials: J
authors.lastname: Li
authors.forename: Fengjing
authors.initials: F
authors.lastname: Jia
authors.forename: Liang
authors.initials: L
authors.lastname: Hong
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003500:Cyclization; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011809:Quinones / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001372:Aza Compounds; D007783:Lactones; D011809:Quinones