title: Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate.
abstract: An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
authors.affiliation: †Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesniére, 76821 Mont Saint Aignan Cedex, France.|‡VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Barré
authors.affiliation: †Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesniére, 76821 Mont Saint Aignan Cedex, France.
authors.forename: Mihaela-Liliana
authors.initials: ML
authors.lastname: Ţînţaş
authors.affiliation: ‡VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
authors.forename: Florent
authors.initials: F
authors.lastname: Alix
authors.affiliation: ‡VFP Therapies, 15 rue François Couperin, 76000 Rouen, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Gembus
authors.affiliation: †Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesniére, 76821 Mont Saint Aignan Cedex, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Papamicaël
authors.affiliation: †Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesniére, 76821 Mont Saint Aignan Cedex, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D005561:Formates / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000475:Alkenes; D005561:Formates; D006846:Hydrocarbons, Halogenated; C030544:formic acid; D010165:Palladium; D002248:Carbon Monoxide