title: Mini-review: Does Notch promote or suppress cancer? New findings and old controversies.
abstract: Notch signaling in tumorigenesis and cancer progression presents a certain enigma. Numerous experimental studies reported significant effects in cancer, yet of varying magnitude and opposite sign. This mini review is aimed to streamline our understanding of the Notch role in tumor progression, and outline future experiments to clarify the modality of Notch function and perspectives of the Notch-based anticancer treatments.
authors.affiliation: Department of Urology, New York University School of Medicine New York, NY 10010 ; Department of Biology, New York City College of Technology, City University of New York Brooklyn, NY, 11201 ; Department of Cell and Developmental Biology, Weill Cornell Medical College New York, NY 10065.
authors.forename: Irina B
authors.initials: IB
authors.lastname: Grishina
keywords: Notch; PTEN; Wnt; cancer