title: Wnt Down, Tumors Wind Up?
abstract: In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an exquisite target for intervention.
authors.affiliation: Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121. 1066 CX Amsterdam, The Netherlands.
authors.forename: Paul
authors.initials: P
authors.lastname: Krimpenfort
authors.affiliation: Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121. 1066 CX Amsterdam, The Netherlands; Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Building 5, Moscow 143026, Russia. Electronic address: a.berns@nki.nl.
authors.forename: Anton
authors.initials: A
authors.lastname: Berns
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism*; D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics*; D004195:Disease Models, Animal; D007420:Intestine, Large / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*
chemical_list: D025601:Adenomatous Polyposis Coli Protein