title: Incidence of chemotherapy-induced nausea and vomiting with moderately emetogenic chemotherapy: ADVICE (Actual Data of Vomiting Incidence by Chemotherapy Evaluation) study.
abstract: OBJECTIVE
  This study aims to determine the incidence of nausea and vomiting (CINV) after moderately emetogenic chemotherapy (MEC), under medical practice conditions and the accuracy with which physicians perceive CINV.
  
  
  METHODS
  Chemotherapy-naive patients receiving MEC between April 2012 and May 2013 were included. Patients completed a diary of the intensity of nausea and number of vomiting episodes. Complete response and complete protection were assessed as secondary endpoints.
  
  
  RESULTS
  Of 261 patients included, 240 were evaluated. Median age was 64 years, 44.2 % were female and 11.2 % were aged less than 50 years; 95.3 % of patients received a combination of 5-hydroxytryptamine 3 (5-HT3) antagonist + corticosteroid as antiemetic treatment. Vomiting within 5 days of chemotherapy administration occurred in 20.8 %, nausea in 42 % and significant nausea in 23.8 % of patients. An increase in the percentage of patients with significant nausea (from 9.4 to 21.7 %) and vomiting (from 9.2 to 16.5 %) was observed from the acute to the delayed phase. Complete response was 84.2 % in the acute phase, 77 % in the late phase and 68.9 % in overall period. Complete protection was 79.5 % in the acute phase, 68.8 % in the late phase and 62.4 % throughout the study period. Physicians estimated prophylaxis would be effective for 75 % of patients receiving MEC, compared with 54.1 % obtained from patients' diary.
  
  
  CONCLUSIONS
  Despite receiving prophylactic treatment, 31 % of patients did not achieve a complete response and 38 % complete protection. In general, nausea was worse controlled than vomiting. The results also showed the late phase was worse controlled than the acute phase in all variables. Healthcare providers overestimated the effectiveness of antiemetic prophylaxis.
authors.affiliation: Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañón, C/ Dr. Esquerdo 46, 28007, Madrid, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Escobar
authors.forename: Gerardo
authors.initials: G
authors.lastname: Cajaraville
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Virizuela
authors.forename: Rosa
authors.initials: R
authors.lastname: Álvarez
authors.forename: Andrés
authors.initials: A
authors.lastname: Muñoz
authors.forename: Olatz
authors.initials: O
authors.lastname: Olariaga
authors.forename: María José
authors.initials: MJ
authors.lastname: Tamés
authors.forename: Begoña
authors.initials: B
authors.lastname: Muros
authors.forename: María Jose
authors.initials: MJ
authors.lastname: Lecumberri
authors.forename: Jaime
authors.initials: J
authors.lastname: Feliu
authors.forename: Purificación
authors.initials: P
authors.lastname: Martínez
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Adansa
authors.forename: María José
authors.initials: MJ
authors.lastname: Martínez
authors.forename: Rafael
authors.initials: R
authors.lastname: López
authors.forename: Ana
authors.initials: A
authors.lastname: Blasco
authors.forename: Pere
authors.initials: P
authors.lastname: Gascón
authors.forename: Virginia
authors.initials: V
authors.lastname: Calvo
authors.forename: Pablo
authors.initials: P
authors.lastname: Luna
authors.forename: Joaquín
authors.initials: J
authors.lastname: Montalar
authors.forename: Patricia
authors.initials: P
authors.lastname: Del Barrio
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Tornamira
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology*; D009369:Neoplasms / Q000188:drug therapy; D010820:Physicians; D011446:Prospective Studies; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents