title: Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma.
abstract: In order to determine the diagnostic and prognostic value of miR-26a in Cholangiocarcinoma (CCA), we compared miR-26a levels in serum from 66 CCA patients and 66 healthy controls, which was followed by serum analysis between the pre-operative serum and post-operative serum of these CCA patients. We found the concentration levels of miR-26a in serum of CCA patients were significantly higher than that from healthy controls (P < 0.01). Furthermore, the concentration levels of miR-26a in the post-operative serum were significantly reduced when compared to the pre-operative serum (P < 0.001). High miR-26a in serum was correlated significantly with clinical stage, distant metastasis, differentiation status, and poor survival of CCA patients. More importantly, serum miR-26a was an independent prognostic marker for CCA. In conclusion, our results suggested that miR-26a in serum might be a potential and useful noninvasive biomarker for the early detection of CCA.
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi Province, P.R. China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Deparment of Orthopedics, No. 88 Hospital of PLA, Tai'an, 271000, Shandong Province, P.R. China.
authors.forename: Kai-Liang
authors.initials: KL
authors.lastname: Zhang
authors.affiliation: Deparment of Aristogenesis, No. 202 Hospital of PLA, Shenyang, 110003, Liaoning Province, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Deparment of Aristogenesis, No. 202 Hospital of PLA, Shenyang, 110003, Liaoning Province, P.R. China.
authors.forename: Xiang-Wei
authors.initials: XW
authors.lastname: Ma
authors.affiliation: Deparment of Aristogenesis, No. 202 Hospital of PLA, Shenyang, 110003, Liaoning Province, P.R. China.
authors.forename: Su-Wen
authors.initials: SW
authors.lastname: Yan
authors.affiliation: Deparment of Aristogenesis, No. 202 Hospital of PLA, Shenyang, 110003, Liaoning Province, P.R. China.
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: Cao
authors.affiliation: Deparment of Aristogenesis, No. 202 Hospital of PLA, Shenyang, 110003, Liaoning Province, P.R. China.
authors.forename: Sheng-Jia
authors.initials: SJ
authors.lastname: Shi
mesh_terms: D001650:Bile Duct Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D045744:Cell Line, Tumor; D018281:Cholangiocarcinoma / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011184:Postoperative Period; D057234:Preoperative Period; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; C528163:MIRN26 microRNA, human
keywords: cholangiocarcinoma; diagnostic; prognosis; serum miR-26a