title: THz Medical Imaging:in vivoHydration Sensing.
abstract: The application of THz to medical imaging is experiencing a surge in both interest and federal funding. A brief overview of the field is provided along with promising and emerging applications and ongoing research. THz imaging phenomenology is discussed and tradeoffs are identified. A THz medical imaging system, operating at ~525 GHz center frequency with ~125 GHz of response normalized bandwidth is introduced and details regarding principles of operation are provided. Two promising medical applications of THz imaging are presented: skin burns and cornea. For burns, images of second degree, partial thickness burns were obtained in rat modelsin vivoover an 8 hour period. These images clearly show the formation and progression of edema in and around the burn wound area. For cornea, experimental data measuring the hydration ofex vivoporcine cornea under drying is presented demonstrating utility in ophthalmologic applications.
authors.affiliation: Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA ( zdeis@seas.ucla.edu ).
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Taylor
authors.affiliation: Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Singh
authors.affiliation: Department of Electrical Engineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Bennett
authors.affiliation: Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Priyamvada
authors.initials: P
authors.lastname: Tewari
authors.affiliation: Department of Surgery and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Kealey
authors.affiliation: Department of Bioengineering and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Neha
authors.initials: N
authors.lastname: Bajwa
authors.affiliation: Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Martin O
authors.initials: MO
authors.lastname: Culjat
authors.affiliation: Department of Surgery, Walter Reed Army Medical Center and the Combat Wound Initiative Program, Washington, DC 20307 USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Stojadinovic
authors.affiliation: Department of Electrical and Computer Engineering, University of California at Santa Barbara, Santa Barbara, CA 93106 USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hubschman
authors.affiliation: Department of Physics, Wright State University, Dayton, OH 45435 USA.
authors.forename: Elliott R
authors.initials: ER
authors.lastname: Brown
authors.affiliation: Department of Electrical Engineering, Department of Bioengineering, Department of Surgery, and the Center for Advanced Surgical and Interventional Technology (CASIT), University of California at Los Angeles, Los Angeles, CA 90095 USA.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Grundfest
keywords: Biological and medical imaging; THz; Terahertz; clinical instruments; hydration interactions; medical diagnostics; submillimeter