title: [Gout - from pathogenesis to treatment - progress in the XXI century].
abstract: Gout has recently become the most common arthritis in developed countries. However studies indicate that treatment of gout is still insufficient. New discoveries including the role of inflammasome, inflammatory cytokines ( Il1β, IL-8,TNF-α), but also identification of the URAT -1 transporter or genetic mutation of SLC2A9 has given better understanding of the pathophysiology of gout and enable to use new therapies. New options in treatment significantly reduced the number of patients resistant to existing procedures, and created opportunities for a better individualization of the treatment. In this authors article in a practical way try to summary knowledge about the pathogenesis of the disease and the current guidelines for the diagnosis, the treatment of non-pharmacological and pharmacological treatment.
authors.affiliation: Medical University of Poznan, Poland: Department of Internal Medicine, Metabolic Disorders and Hypertension;
authors.forename: Justyna
authors.initials: J
authors.lastname: Cal-Kocikowska
authors.affiliation: Medical University of Poznan, Poland: Department of Internal Medicine, Metabolic Disorders and Hypertension;
authors.forename: Marta
authors.initials: M
authors.lastname: Nawrocka
authors.affiliation: Medical University of Poznan, Poland: Department of Education and Treatment of Obesity and Metabolic Disorders.
authors.forename: Paweł
authors.initials: P
authors.lastname: Bogdański
mesh_terms: D016207:Cytokines / Q000378:metabolism; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics; D006073:Gout / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D009154:Mutation; D027361:Organic Anion Transporters / Q000235:genetics; D027701:Organic Cation Transport Proteins / Q000235:genetics
chemical_list: D016207:Cytokines; D051246:Glucose Transport Proteins, Facilitative; D027361:Organic Anion Transporters; D027701:Organic Cation Transport Proteins; C491241:SLC22A12 protein, human
keywords: allopurinol; febuxostat; gout; hyperuricemia