title: [Clinical observation on treatment of mycotic vaginitis with Sophora gel combined with Fluconazole capsules].
abstract: Mycotic vaginitis is a common and frequently-occurring gynaecopathia and easy to attack repeatedly, so painful to patients. In this study, the authors observed the clinical efficacy of Sophora gel combined with Fluconazole capsules in treating mycotic vaginitis, in order to seek an effective method for treating mycotic vaginitis. Totally 85 patients with mycotic vaginitis treated in our hospital between December 2012 and July 2014 were randomly divided into the treatment group (43 patients) and the control group (42 patients). The treatment group was given vaginally Sophora gel (one piece every night for 14 days) and orally Fluconazole capsules (150 mg, once every three days, four times in total); The control group was only administered with Fluconazole capsules. The total efficacy, cure rate, recurrence rate and clinical symptom improvements of the two groups were observed. The results show that the total efficacy, the cure rate and the recurrence rate of the treatment group vs. the control group were respectively 97.7%, 90.7% and 2.6% vs. 83.3%, 71.4% and 20.0%, with statistical significance in their differences (P < 0.05). The treatment group showed reduced leucorrhea, pruritus vulvae disappearance and earlier mucosal hyperemia disappearance than the control group, with statistical significance in their differences (P < 0.05). In conclusion Sophora gel combined with Fluconazole capsules can improve antifungal activity of drugs, relieve clinical symptoms, shorten the course of disease, enhance the cure rate and reduce the recurrence rate; So this therapy can be widely applied in clinic.
authors.forename: Na-mei
authors.initials: NM
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Cui
authors.forename: Chun-fen
authors.initials: CF
authors.lastname: Ma
authors.forename: Hui-xia
authors.initials: HX
authors.lastname: Wang
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002214:Capsules / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*; D029909:Sophora / Q000737:chemistry*; D016896:Treatment Outcome; D014627:Vaginitis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D002214:Capsules; D004365:Drugs, Chinese Herbal; D015725:Fluconazole