title: Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects.
abstract: In the present study, we describe the synthesis of a new set of 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems. The products were assayed for various types of biological activities like anti-inflammatory and antioxidative activity. Compounds 4c, 4f, 12a, 14, 16, and 19 were found to reduce carrageenan- and dextran-induced inflammation in rats. In addition, compounds 4f and 12a were found to have antioxidative radical scavenging activity. Furthermore, these compounds were tested in the model system Caenorhabiditis elegans and there increased heat stress resistance, reduced the formation of advanced glycation end products, and finally extended the life span.
authors.affiliation: Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, Jeddah, Saudi Arabia.|Department of Chemistry, Faculty of Science, El-Minia University, El-Minia, Egypt.
authors.forename: Ramadan A
authors.initials: RA
authors.lastname: Mekheimer
authors.affiliation: Department of Chemistry, Faculty of Science, El-Minia University, El-Minia, Egypt.|Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Ahmed A Radwan
authors.initials: AA
authors.lastname: Sayed
authors.affiliation: Department of Chemistry, Faculty of Education, AlFashir University, AlFashir, Sudan.
authors.forename: Eltaib A
authors.initials: EA
authors.lastname: Ahmed
authors.affiliation: Department of Chemistry, Faculty of Science, El-Minia University, El-Minia, Egypt.
authors.forename: Kamal U
authors.initials: KU
authors.lastname: Sadek
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism; D002351:Carrageenan; D003911:Dextrans; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006031:Glycosylation; D018869:Heat-Shock Response / Q000187:drug effects; D008136:Longevity / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D010851:Picrates / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D003911:Dextrans; D017127:Glycation End Products, Advanced; D010851:Picrates; D011725:Pyridines; D014230:Triazoles; C045575:1,2,4-triazole; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: 1,2,4-Triazolo[1,5-a]pyridines; Anti-inflammatory; Antioxidant; Caenorhabiditis elegans; Synthesis