title: Evidence of Spontaneous Recovery of Granulosa-Theca Cell Tumour in a Heifer: A Retrospective Report.
abstract: A 14-month-old Japanese Black heifer was evaluated on Day 0 (D 0) for enlargement of the right ovary (RO). Transrectal ultrasonography (TRUS) revealed that the RO was markedly enlarged and multicystic, while the left ovary (LO) was small and inactive. The presumptive diagnosis was granulosa-theca cell tumour (GTCT), which was confirmed by markedly elevated plasma anti-Müllerian hormone (AMH) of 4.42 ng/ml. Therefore, ovariectomy of the RO was the treatment of choice. The heifer was checked by TRUS and blood sampling on D 42, D 63 and immediately before ovariectomy on D 85. On D 42, TRUS did not show marked changes in either ovary in comparison with D 0. However, on D 63, the RO had transformed into a single cyst, and on D 85, the LO had resumed cyclic activity. The RO was extracted on D 85 by hand-assisted laparoscopic ovariectomy to allow better control. Unexpectedly, histopathology revealed the lesion to be a fluid-filled cystic structure, with no neoplastic proliferation of follicular epithelium that would indicate GTCT. The wall of the cystic structure consisted of collagen fibres and a few degenerated granulosa cells. The retrospective hormonal analysis revealed that the AMH concentrations had markedly dropped on D 63 and 85, which coincided with resumption of cyclicity in the LO. These findings suggest that the GTCT had self-cured and transformed into a cyst-like structure. The heifer then received an oestrous synchronization regime on D 105, was artificially inseminated on D 115 and became pregnant.
authors.affiliation: Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.|Department of Theriogenology, Faculty of Veterinary Medicine, University of Mansoura, Mansoura, Egypt.
authors.forename: H
authors.initials: H
authors.lastname: El-Sheikh Ali
authors.affiliation: Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Kitahara
authors.affiliation: Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Torisu
authors.affiliation: Japan Animal Referral Medical Center, Takatsu-ku, Kawasaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nibe
authors.affiliation: Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.affiliation: Laboratory of Veterinary Surgery, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hidaka
authors.affiliation: Laboratory of Theriogenology, Department of Veterinary Sciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Osawa
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone / Q000097:blood; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology* / Q000601:surgery; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D058733:Hand-Assisted Laparoscopy / Q000662:veterinary; D006728:Hormones / Q000097:blood; D010051:Ovarian Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D010052:Ovariectomy / Q000662:veterinary; D011247:Pregnancy; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D013798:Thecoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D006728:Hormones; D054304:Anti-Mullerian Hormone