title: Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder.
abstract: Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm(3), respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents. Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD.
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Tatiana
authors.identifier: 0000-0002-2583-4381
authors.initials: T
authors.lastname: Lauxen Peruzzolo
authors.affiliation: Hospital de Clínicas de Porto Alegre, Division of Medical Physics and Radiation Protection, 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Anes
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Andre de Moura
authors.initials: Ade M
authors.lastname: Kohmann
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Ana Claudia Mércio Loredo
authors.initials: AC
authors.lastname: Souza
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Ramiro Borges
authors.identifier: 0000-0002-4218-4800
authors.initials: RB
authors.lastname: Rodrigues
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Juliana Basso
authors.initials: JB
authors.lastname: Brun
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Roberta
authors.initials: R
authors.lastname: Peters
authors.affiliation: Bipolar Disorder Unit, Molecular Psychiatry Unit and National Institute for Translational Medicine, CNPq., 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Bianca Wollenhaupt
authors.initials: BW
authors.lastname: de Aguiar
authors.affiliation: Federal University, UFRGS, 90035-903 Porto Alegre, RS, Brazil ; UTHealth, Houston, TX 77030, USA.
authors.forename: Flavio
authors.initials: F
authors.lastname: Kapczinski
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil.
authors.forename: Silzá
authors.initials: S
authors.lastname: Tramontina
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil ; ADHD Outpatient Program (PRODAH), UFRGS, 90035-903 Porto Alegre, RS, Brazil ; National Science and Technology Institute for Children and Adolescents, 05403-010 São Paulo, SP, Brazil.
authors.forename: Luis Augusto Paim
authors.initials: LA
authors.lastname: Rohde
authors.affiliation: Pediatric Bipolar Disorder Outpatient Program (ProCAB), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-903 Porto Alegre, RS, Brazil ; University of Texas Health Science Center, Houston, TX 77030, USA.
authors.forename: Cristian Patrick
authors.initials: CP
authors.lastname: Zeni
mesh_terms: D000293:Adolescent; D001714:Bipolar Disorder / Q000097:blood* / Q000473:pathology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human