title: The Role of Autophagy in Salivary Gland Homeostasis and Stress Responses.
abstract: Autophagy is a catabolic process that has been shown to have a role in many cellular processes including the removal of excessive or damaged proteins and protein aggregates. The salivary glands play a critical role in oral health, and their secretory capacity may be critically intertwined with the autophagic process. This review describes the role of autophagy activation in normal salivary gland homeostasis and during the glandular stress responses of therapeutic radiation, ductal ligation, autoimmunity, and salivary gland adenoid cystic carcinoma.
authors.affiliation: Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA.
authors.forename: M
authors.initials: M
authors.lastname: Morgan-Bathke
authors.affiliation: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.
authors.forename: H H
authors.initials: HH
authors.lastname: Lin
authors.affiliation: Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope, Duarte, CA, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Ann
authors.affiliation: Department of Nutritional Sciences, University of Arizona, Tucson, AZ, USA limesank@u.arizona.edu.
authors.forename: K H
authors.initials: KH
authors.lastname: Limesand
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D001343:Autophagy / Q000276:immunology / Q000502:physiology* / Q000528:radiation effects; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism; D004195:Disease Models, Animal; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008026:Ligation; D012468:Salivary Gland Neoplasms / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism / Q000528:radiation effects; D020123:Sirolimus / Q000494:pharmacology; D013312:Stress, Physiological
chemical_list: D020123:Sirolimus
keywords: Sjogren’s syndrome; cancer; ductal ligation; radiation; rapalogues; salivary physiology