title: Enterolacaciamine as a potential O-GlcNAcase activator from the leaves of Enterolobium cyclocarpum.
abstract: Enterolacaciamine (1), a new potential O-GlcNAcase activator, along with three known triterpenoid saponins, concinnoside B (2), concinnoside D (3), and julibroside A3 (4) was isolated from the leaves of Enterolobium cyclocarpum. Their structures were elucidated by chemical and spectroscopic methods (UV, MS, 1D and 2D NMR). Their effects on O-GlcNAcase activity were evaluated using O-GlcNAcase enzymatic assay. The results showed that compound 1 could obviously enhance the activity of O-GlcNAcase.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 266003 Qingdao, PR China.
authors.forename: Dao-Liang
authors.initials: DL
authors.lastname: Wang
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria.
authors.forename: Abimbola
authors.initials: A
authors.lastname: Sowemimo
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 266003 Qingdao, PR China.
authors.forename: Yu-Chao
authors.initials: YC
authors.lastname: Gu
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 266003 Qingdao, PR China.
authors.forename: Shang
authors.initials: S
authors.lastname: Gao
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 266003 Qingdao, PR China. Electronic address: liuhongb@ouc.edu.cn.
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Liu
authors.affiliation: Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D020536:Enzyme Activators / Q000737:chemistry* / Q000302:isolation & purification; D007887:Fabaceae / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism*
chemical_list: D020536:Enzyme Activators; D012503:Saponins; D014315:Triterpenes; C000603146:enterolacaciamine; C110628:hexosaminidase C; D001619:beta-N-Acetylhexosaminidases
keywords: Acacic acid lactones; Enterolobium cyclocarpum; O-GlcNAcase; Triterpenoid saponins