title: Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy.
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Wiseman
authors.affiliation: Metabolic Laboratory, Department of Clinical Chemistry, Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Struys
authors.affiliation: Biobank, Manchester Cancer Research Centre, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
authors.forename: D P
authors.initials: DP
authors.lastname: Wilks
authors.affiliation: Molecular Biology Core Facility, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
authors.forename: C I
authors.initials: CI
authors.lastname: Clark
authors.affiliation: Department of Haematology, The Christie NHS Foundation Trust, Manchester, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Dennis
authors.affiliation: Metabolic Laboratory, Department of Clinical Chemistry, Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: E E W
authors.initials: EE
authors.lastname: Jansen
authors.affiliation: Metabolic Laboratory, Department of Clinical Chemistry, Free University Medical Center, Amsterdam, The Netherlands.
authors.forename: G S
authors.initials: GS
authors.lastname: Salomons
authors.affiliation: Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
authors.forename: T C P
authors.initials: TC
authors.lastname: Somervaille
mesh_terms: D005787:Gene Frequency; D005977:Glutarates / Q000097:blood*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D005977:Glutarates; C019417:alpha-hydroxyglutarate; D007521:Isocitrate Dehydrogenase