title: Abnormal Connectivity Within Executive Resting-State Network in Migraine With Aura.
abstract: OBJECTIVE
  To evaluate the executive control network connectivity integrity in patients with migraine with aura, in the interictal period, in comparison to patients with migraine without aura and healthy controls.
  
  
  METHODS
  Using resting-state functional magnetic resonance imaging, we compared executive control network functional connectivity in 20 patients with migraine with aura vs 20 sex and age-matched patients with migraine without aura and 20 healthy controls, and assessed the correlation between executive control network functional connectivity and clinical features of patients with migraine. We used voxel-based morphometry and diffusion tensor imaging to investigate potential structural or microstructural changes.
  
  
  RESULTS
  Neuropsychological data revealed no significant executive dysfunction in patients with migraine. Resting-state functional magnetic resonance imaging showed significant group differences in right middle frontal gyrus (Talairach coordinates x, y, z: +26, +2, +48) and dorsal anterior cingulate cortex (Talairach coordinates x, y, z: +6, +13, +49), indicating that these areas had a decreased component activity in both patients with migraine with and without aura when compared with healthy controls. Conversely, there were no significant differences in the executive control network functional connectivity between patients with migraine with and without aura (P < .05, cluster-level corrected). These functional abnormalities are independent of structural and microstructural changes and did not significantly correlate with clinical parameters.
  
  
  CONCLUSIONS
  Our data demonstrate a disrupted executive control network functional connectivity in patients with migraine with and without aura, in the interictal period. Although this functional phenomenon is present in the absence of clinically relevant executive deficits, it may reflect a vulnerability to executive high-demanding conditions of daily living activities in patients with migraine.
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Tessitore
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.|Institute for Diagnosis and Care "Hermitage Capodimonte,", Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Conte
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.|Institute for Diagnosis and Care "Hermitage Capodimonte,", Naples, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Giordano
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: De Stefano
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Lavorgna
authors.affiliation: MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Corbo
authors.affiliation: MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Caiazzo
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Baronissi, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Esposito
authors.affiliation: Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Naples, Italy.|MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.|Institute for Diagnosis and Care "Hermitage Capodimonte,", Naples, Italy.
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Tedeschi
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020325:Migraine with Aura / Q000175:diagnosis* / Q000378:metabolism; D020326:Migraine without Aura / Q000175:diagnosis* / Q000378:metabolism; D009415:Nerve Net / Q000378:metabolism / Q000473:pathology*; D012146:Rest / Q000502:physiology
keywords: aura; executive control network; executive functions; functional magnetic resonance imaging; migraine