title: Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.
abstract: Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
authors.forename: Michael
authors.initials: M
authors.lastname: Hawkes
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Conroy
authors.forename: Robert O
authors.initials: RO
authors.lastname: Opoka
authors.forename: Sophie
authors.initials: S
authors.lastname: Namasopo
authors.forename: Kathleen
authors.initials: K
authors.lastname: Zhong
authors.forename: W Conrad
authors.initials: WC
authors.lastname: Liles
authors.forename: Chandy C
authors.initials: CC
authors.lastname: John
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Kain
mesh_terms: D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D037621:Artemisinins / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D017125:Genes, Protozoan; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology* / Q000473:pathology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D014454:Uganda
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C031327:artemisinin
keywords: Plasmodium falciparum; Uganda; artesunate; child; kelch 13 propeller domain; malaria; parasites; resistance; single nucleotide polymorphism