title: STAT3 Decoy ODN Therapy for Cancer.
abstract: As an oncogene, over-activated signal transducer and activator of transcription 3 (STAT3) has been detected in many tumors. STAT3 controls cell differentiation, proliferation, and survival, and is associated with angiogenesis and immune dysfunction during tumorigenesis. Double-stranded decoy oligodeoxynucleotide (ODN) targeting over-activated STAT3 in tumor cells have shown significant antitumor efficiency. Here, we describe the materials and methods involved in STAT3 decoy ODN therapy for cancer including both the antitumor effect directly and immunotherapy indirectly.
authors.affiliation: Biology Department, Shandong Quality Inspection Center For Medical Devices, Jinan, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D015153:Blotting, Western; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004195:Disease Models, Animal; D057075:Enzyme Assays; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007109:Immunity; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D007694:Killer Cells, Natural / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D008156:Luciferases / Q000378:metabolism; D008819:Mice, Nude; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology; D009838:Oligodeoxyribonucleotides / Q000235:genetics* / Q000627:therapeutic use*; D060888:Real-Time Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000235:genetics* / Q000627:therapeutic use*; D014162:Transfection
chemical_list: D009838:Oligodeoxyribonucleotides; D050796:STAT3 Transcription Factor; D008156:Luciferases; D016650:Fluorescein-5-isothiocyanate