title: Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia.
abstract: OBJECTIVE
  To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.
  
  
  METHODS
  A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.
  
  
  RESULTS
  The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.
  
  
  CONCLUSIONS
  Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.
authors.forename: Carolina
authors.initials: C
authors.lastname: D'Aurea
authors.forename: Dalva
authors.initials: D
authors.lastname: Poyares
authors.forename: Ronaldo D
authors.initials: RD
authors.lastname: Piovezan
authors.forename: Gisele
authors.initials: G
authors.lastname: Passos
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
authors.forename: Marco Tulio de
authors.initials: MT
authors.lastname: Mello
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002908:Chronic Disease; D004812:Epidemiologic Methods; D005215:Fasting; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D017286:Polysomnography; D012016:Reference Values; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood* / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D006854:Hydrocortisone