title: [Cognitive impairment in a toxic lesion of the brain].
abstract: OBJECTIVE
  To identify features of cognitive impairment in patients with toxic (mercury or alcohol) encephalopathy.
  
  
  METHODS
  The study involved 36 patients with chronic mercury intoxication and 30 people with chronic alcoholism. A control group included 30 age-matched healthy men who were not exposed to toxic substances and alcohol abuse. All patients underwent neuropsychological examination, which involved a set of neuropsychological Luria rated memory status, praxis, gnosis and speeches. MMSE and FAB were used for the diagnosis of moderate cognitive impairment. Computer electroencephalography and cognitive evoked potentials method were used as well.
  
  
  CONCLUSIONS
  The diffuse brain injury in toxic encephalopathy (alcohol and mercury) on EEG, and according to the results of neuropsychological testing was identified. Changes in analytical and synthetic thinking, audio-verbal, long-term, visual memory, reciprocal coordination, finger gnosis, impressive speech were observed in mercury encephalopathy. Functional failure of the frontal lobe and the premotor area of the left hemisphere were revealed in alcoholic encephalopathy.
authors.affiliation: East-Siberian Scientific Centre of Human Ecology, Angarsk.
authors.forename: E V
authors.initials: EV
authors.lastname: Katamanova
authors.affiliation: East-Siberian Scientific Centre of Human Ecology, Angarsk.
authors.forename: V S
authors.initials: VS
authors.lastname: Rukavishnikov
authors.affiliation: East-Siberian Scientific Centre of Human Ecology, Angarsk.
authors.forename: O L
authors.initials: OL
authors.lastname: Lakhman
authors.affiliation: East-Siberian Scientific Centre of Human Ecology, Angarsk.
authors.forename: O I
authors.initials: OI
authors.lastname: Shevchenko
authors.affiliation: East-Siberian Scientific Centre of Human Ecology, Angarsk.
authors.forename: I A
authors.initials: IA
authors.lastname: Denisova
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D020262:Mercury Poisoning, Nervous System / Q000150:complications* / Q000503:physiopathology; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D013997:Time Factors