title: Continuing harmonization of terminology and innovations for methodologies in developmental toxicology: Report of the 8th Berlin Workshop on Developmental Toxicity, 14-16 May 2014.
abstract: This article is a report of the 8th Berlin Workshop on Developmental Toxicity held in May 2014. The main aim of the workshop was the continuing harmonization of terminology and innovations for methodologies used in the assessment of embryo- and fetotoxic findings. The following main topics were discussed: harmonized categorization of external, skeletal, visceral and materno-fetal findings into malformations, variations and grey zone anomalies, aspects of developmental anomalies in humans and laboratory animals, and innovations for new methodologies in developmental toxicology. The application of Version 2 terminology in the DevTox database was considered as a useful improvement in the categorization of developmental anomalies. Participants concluded that initiation of a project for comparative assessments of developmental anomalies in humans and laboratory animals could support regulatory risk assessment and university-based training. Improvement of new methodological approaches for alternatives to animal testing should be triggered for a better understanding of developmental outcomes.
authors.affiliation: Federal Institute for Risk Assessment, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Solecki
authors.affiliation: Federal Institute for Risk Assessment, Germany.
authors.forename: Martina
authors.initials: M
authors.lastname: Rauch
authors.affiliation: Federal Institute for Risk Assessment, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gall
authors.affiliation: Fraunhofer Institute for Toxicology and Experimental Medicine, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Buschmann
authors.affiliation: Ruth Clark Associates Ltd., United Kingdom.
authors.forename: Ruth
authors.initials: R
authors.lastname: Clark
authors.affiliation: Covance Laboratories GmbH, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Fuchs
authors.affiliation: Fudan University, Shanghai, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Kan
authors.affiliation: Federal Institute for Risk Assessment, Germany. Electronic address: devtox@bfr.bund.de.
authors.forename: Verena
authors.initials: V
authors.lastname: Heinrich
authors.affiliation: Fraunhofer Institute for Toxicology and Experimental Medicine, Germany.
authors.forename: Rupert
authors.initials: R
authors.lastname: Kellner
authors.affiliation: U.S. Environmental Protection Agency, Washington, DC, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Knudsen
authors.affiliation: Shanghai Institute of Planned Parenthood Research, Shanghai, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Li
authors.affiliation: U.S. Environmental Protection Agency, Washington, DC, USA.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Makris
authors.affiliation: Japanese Teratology Society, Kagioshima, Japan.
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Ooshima
authors.affiliation: Oswaldo Cruz Foundation, Brazil.
authors.forename: Francisco
authors.initials: F
authors.lastname: Paumgartten
authors.affiliation: RIVM Bilthoven, The Netherlands.
authors.forename: Aldert H
authors.initials: AH
authors.lastname: Piersma
authors.affiliation: Federal Institute for Risk Assessment, Germany; Charité Universitätsmedizin, Berlin, Germany.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Schönfelder
authors.affiliation: Federal Institute for Risk Assessment, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Oelgeschläger
authors.affiliation: Charité Universitätsmedizin, Berlin, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Schaefer
authors.affiliation: Shiga University of Medical Sciences, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Shiota
authors.affiliation: Toxicologist, Berlin, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Ulbrich
authors.affiliation: Shanghai Institute of Planned Parenthood Research, Shanghai, China.
authors.forename: Xuncheng
authors.initials: X
authors.lastname: Ding
authors.affiliation: Charité Universitätsmedizin, Berlin, Germany.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Chahoud
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D006801:Humans; D018570:Risk Assessment; D013723:Teratogens / Q000633:toxicity; D009626:Terminology as Topic; D014116:Toxicology / Q000379:methods
chemical_list: D013723:Teratogens
keywords: Developmental toxicology; Grey zone anomalies; Harmonization; Human anomalies; Malformation; Reproductive toxicology; Terminology; Variation