title: Short- and Long-Term Effectiveness of a Subject's Specific Novel Brain and Vestibular Rehabilitation Treatment Modality in Combat Veterans Suffering from PTSD.
abstract: BACKGROUND
  Treatment for post-traumatic stress disorder (PTSD) in combat veterans that have a long-term positive clinical effect has the potential to modify the treatment of PTSD. This outcome may result in changed and saved lives of our service personnel and their families. In a previous before-after-intervention study, we demonstrated high statistical and substantively significant short-term changes in the Clinician Administered DSM-IV PTSD Scale (CAPS) scores after a 2-week trial of a subject's particular novel brain and vestibular rehabilitation (VR) program. The long-term maintenance of PTSD severity reduction was the subject of this study.
  
  
  METHODS
  We studied the short- and long-term effectiveness of a subject's particular novel brain and VR treatment of PTSD in subjects who had suffered combat-related traumatic brain injuries in terms of PTSD symptom reduction. The trial was registered as ClinicalTrials.gov Identifier: NCT02003352. We analyzed the difference in the CAPS scores pre- and post-treatment (1 week and 3 months) using our subjects as their matched controls.
  
  
  RESULTS
  The generalized least squares (GLS) technique demonstrated that with our 26 subjects in the 3 timed groups the R (2) within groups was 0.000, R (2) between groups was 0.000, and overall the R (2) was 0.000. The GLS regression was strongly statistically significant z = 21.29, p < 0.001, 95% CI [58.7, 70.63]. The linear predictive margins over time demonstrated strong statistical and substantive significance of decreasing PTSD severity scores for all timed CAPS tests.
  
  
  CONCLUSIONS
  Our investigation has the promise of the development of superior outcomes of treatments in this area that will benefit a global society. The length of the treatment intervention involved (2 weeks) is less that other currently available treatments and has profound implications for cost, duration of disability, and outcomes in the treatment of PTSD in combat veterans.
authors.affiliation: Carrick Institute , Cape Canaveral, FL , USA ; Global Clinical Scholars Research Training Program, Harvard Medical School , Boston, MA , USA ; Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Frederick Robert
authors.initials: FR
authors.lastname: Carrick
authors.affiliation: Carrick Institute , Cape Canaveral, FL , USA ; Electrical and Computer Engineering, University of Wyoming , Laramie, WY , USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Pagnacco
authors.affiliation: Carrick Institute , Cape Canaveral, FL , USA ; Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Kate
authors.initials: K
authors.lastname: McLellan
authors.affiliation: Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Ross
authors.initials: R
authors.lastname: Solis
authors.affiliation: Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Shores
authors.affiliation: Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Fredieu
authors.affiliation: Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Joel Brandon
authors.initials: JB
authors.lastname: Brock
authors.affiliation: Neurology, Carrick Brain Center , Dallas, TX , USA.
authors.forename: Cagan
authors.initials: C
authors.lastname: Randall
authors.affiliation: Carrick Institute , Cape Canaveral, FL , USA ; Electrical and Computer Engineering, University of Wyoming , Laramie, WY , USA.
authors.forename: Cameron
authors.initials: C
authors.lastname: Wright
authors.affiliation: Carrick Institute , Cape Canaveral, FL , USA ; Electrical and Computer Engineering, University of Wyoming , Laramie, WY , USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Oggero
keywords: DSM-IV CAPS; PTSD; brain rehabilitation; off vertical axis rotation; vestibular rehabilitation