title: Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma.
abstract: OBJECTIVE
  Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were immune response-related indicators. Preoperative NLR and PLR had been considered to be related to the prognosis of various cancers. The objective of this study was to evaluate the prognostic significance of NLR and PLR in patients with gallbladder carcinoma (GBC).
  
  
  METHODS
  From 2001 to 2013, 145 patients with GBC were recruited in this retrospective study. Cutoff values of NLR and PLR were determined by receiver operating characteristic curves (ROC). The correlation of clinical data, including tumor differentiation, nevin stage, TNM stage, operation margin, operation mode, NLR, PLR, hemoglobin, C reactive protein (CRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) with median survival period of patients was analyzed by univariate survival analysis. The multivariate prognosis analysis was performed to select the independent prognostic factors.
  
  
  RESULTS
  The cutoff values of NLR and PLR were 1.94 and 113.34, respectively. Compared with low NLR and low PLR group, the 5-year survival rates in high NLR and high PLR group were reduced (P < 0.05). The degree of tumor differentiation, nevin stage, TNM stage, operation mode, NLR, PLR, CA199, total bilirubin, CRP and CEA were associated with the median survival period of patients (P < 0.01). The multivariate prognosis analysis showed that NLR, nevin stage, operation mode and hemoglobin were independent prognostic factors (P < 0.05).
  
  
  CONCLUSIONS
  Preoperative NLR and PLR were closely related to prognosis of patients with GBC and might be useful for the evaluation of prognosis of patients with GBC.
authors.affiliation: Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China.|Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
authors.forename: C
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Central Laboratory, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
authors.forename: J
authors.initials: J
authors.lastname: Sun
authors.affiliation: Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China. xunqu0809@163.com.
authors.forename: X
authors.initials: X
authors.lastname: Qu
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology / Q000601:surgery; D000368:Aged; D001792:Blood Platelets; D002097:C-Reactive Protein / Q000378:metabolism; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D018196:Carcinoma, Adenosquamous / Q000097:blood* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology / Q000601:surgery; D005260:Female; D005706:Gallbladder Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009504:Neutrophils; D010976:Platelet Count; D057234:Preoperative Period; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein
keywords: Five-year survival rate; Gallbladder cancer; Neutrophil/lymphocyte ratio; Platelet/lymphocyte ratio; Prognosis