title: Effects of testosterone replacement therapy on nocturia and quality of life in men with hypogonadism: a subanalysis of a previous prospective randomized controlled study in Japan.
abstract: OBJECTIVE
  We investigated the effects of testosterone replacement therapy (TRT) on nocturia and general health among men with hypogonadism and nocturia.
  
  
  METHODS
  From our previous EARTH study population, 64 patients with a clinical diagnosis of nocturia (two or more times per one night) and hypogonadism, comprising the TRT group (n = 31) and controls (n = 33), were included in this analysis. The TRT group was administered 250 mg of testosterone enanthate as an intramuscular injection every 4 weeks for 6 months. All patients responded to the following questionnaires: International Prostatic Symptoms Score (IPSS), Aging Male Symptoms (AMS) score and Short Form-36 health survey at baseline and 6-month visit. These categories were compared based on changes from baseline to the 6-month visit between TRT and control groups.
  
  
  RESULTS
  At the 6-month visit, the TRT group had a significant decrease in IPSS question no. 7 and AMS question no. 4, whereas no significant changes were observed in the control group. Additionally, role limitation because of health program, vitality and mental health domains were significantly improved in the TRT group.
  
  
  CONCLUSIONS
  Six-month TRT may improve nocturia, sleep conditions and quality of life among men with hypogonadism and nocturia.
authors.affiliation: a Department of Urology , Ishikawa Prefectural Central Hospital , Kanazawa, Ishikawa , Japan .
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Shigehara
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konaka
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Eitetsu
authors.initials: E
authors.lastname: Koh
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Koji
authors.initials: K
authors.lastname: Izumi
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kitagawa
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Atsushi
authors.initials: A
authors.lastname: Mizokami
authors.affiliation: a Department of Urology , Ishikawa Prefectural Central Hospital , Kanazawa, Ishikawa , Japan .
authors.forename: Takao
authors.initials: T
authors.lastname: Nakashima
authors.affiliation: c Department of Urology , Nomi City Hospital , Nomi, Ishikawa , Japan , and.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shimamura
authors.affiliation: d Division of Male Infertility , Center for Infertility and IVF, International University of Health and Welfare , Nasushiobara, Tochigi , Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Iwamoto
authors.affiliation: b Department of Integrative Cancer Therapy and Urology , Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa , Japan .
authors.forename: Mikio
authors.initials: M
authors.lastname: Namiki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000728:Androgens / Q000008:administration & dosage*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000188:drug therapy*; D007564:Japan; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000728:Androgens; D013739:Testosterone; C004648:testosterone enanthate
keywords: Hypogonadism; nocturia; quality of life; testosterone replacement therapy