title: Synthesis of a novel series of fluoroarene derivatives of artemisinin as potent antifungal and anticancer agent.
abstract: A series of new fluoroarene derivatives of artemisinin were prepared using Suzuki and Sonogashira cross-coupling reactions. An antifungal and antitumor activity was evaluated against opportunistic pathogen Fusarium oxysporum and Hela cancer cell line. All these derivatives have shown moderate to good activity.
authors.affiliation: CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors.forename: Pori
authors.initials: P
authors.lastname: Buragohain
authors.affiliation: CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors.forename: Naresh
authors.initials: N
authors.lastname: Surineni
authors.affiliation: CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India. Electronic address: ncbarua2000@yahoo.co.in.
authors.forename: Nabin C
authors.initials: NC
authors.lastname: Barua
authors.affiliation: CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors.forename: Purnajyoti D
authors.initials: PD
authors.lastname: Bhuyan
authors.affiliation: CSIR-North East Institute of Science and Technology, Jorhat 785006, Assam, India.
authors.forename: Paran
authors.initials: P
authors.lastname: Boruah
authors.affiliation: Institute of Bioresources and Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Jagat C
authors.initials: JC
authors.lastname: Borah
authors.affiliation: Institute of Bioresources and Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Surbala
authors.initials: S
authors.lastname: Laisharm
authors.affiliation: Institute of Bioresources and Sustainable Development, Takyelpat, Imphal 795001, Manipur, India.
authors.forename: Dinesh Singh
authors.initials: DS
authors.lastname: Moirangthem
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D037621:Artemisinins / Q000737:chemistry* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005464:Fluorobenzenes / Q000737:chemistry* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D037621:Artemisinins; D005464:Fluorobenzenes; C031327:artemisinin
keywords: Anticancer; Antifungal; Artemisinin; Fusarium oxysporum; Suzuki cross-coupling