title: A knowledgebase resource for interleukin-17 family mediated signaling.
abstract: Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. jyoti@ibioinformatics.org.|Manipal University, Madhav Nagar, Manipal, 576104, India. jyoti@ibioinformatics.org.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Sharma
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. lavanya@ibioinformatics.org.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Balakrishnan
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. keshavadatta@ibioinformatics.org.|School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. keshavadatta@ibioinformatics.org.
authors.forename: Keshava K
authors.initials: KK
authors.lastname: Datta
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. nandini.jhmi@gmail.com.
authors.forename: Nandini A
authors.initials: NA
authors.lastname: Sahasrabuddhe
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. aafaque@ibioinformatics.org.|School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. aafaque@ibioinformatics.org.
authors.forename: Aafaque Ahmad
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. apeksha@ibioinformatics.org.|Bioinformatics Centre, School of Life Sciences, Pondicherry University, Puducherry, 605014, India. apeksha@ibioinformatics.org.
authors.forename: Apeksha
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authors.lastname: Sahu
authors.affiliation: Manipal University, Madhav Nagar, Manipal, 576104, India. asksinghal@gmail.com.|Kasturba Medical College, Mangalore, 575001, India. asksinghal@gmail.com.
authors.forename: Anish
authors.initials: A
authors.lastname: Singhal
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA. get.derese@gmail.com.
authors.forename: Derese
authors.initials: D
authors.lastname: Getnet
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. rajrrnbt@gmail.com.|Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Poojappura, Kerala, 695014, India. rajrrnbt@gmail.com.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Raju
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. aditi@ibioinformatics.org.|Manipal University, Madhav Nagar, Manipal, 576104, India. aditi@ibioinformatics.org.
authors.forename: Aditi
authors.initials: A
authors.lastname: Chatterjee
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. harsha@ibioinformatics.org.|School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. harsha@ibioinformatics.org.
authors.forename: Harsha
authors.initials: H
authors.lastname: Gowda
authors.affiliation: Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. keshav@ibioinformatics.org.|Manipal University, Madhav Nagar, Manipal, 576104, India. keshav@ibioinformatics.org.
authors.forename: T S
authors.initials: TS
authors.lastname: Keshava Prasad
authors.affiliation: Command Hospital (Air Force), Bangalore, 560007, India. shankar@ibioinformatics.org.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Shankar
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA. pandey@jhmi.edu.
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
keywords: Activation; Differential expression; Inhibition; NetPath; Post-translational modifications; Protein-protein interaction; Translocation