title: Levetiracetam-induced severe acute granulomatous interstitial nephritis.
abstract: Granulomatous interstitial nephritis (GIN) is an uncommon cause of renal failure, which may be caused by drugs. Levetiracetam is an increasingly used anti-epileptic medication that is not known to cause renal toxicity in adults. To our knowledge, levetiracetam has not previously been reported as a cause of GIN. We report the case of a 69-year-old woman who developed haemodialysis-requiring acute renal failure after commencement of treatment with levetiracetam, which was shown to be GIN by renal biopsy. She made a complete recovery with cessation of levetiracetam and treatment with steroids.
authors.affiliation: Renal Unit, Liverpool Hospital, Sydney, Australia.
authors.forename: Katrina
authors.initials: K
authors.lastname: Chau
authors.affiliation: Department of Anatomical Pathology, South Western Area Pathology Service, Sydney, Australia.
authors.forename: Jim
authors.initials: J
authors.lastname: Yong
authors.affiliation: Department of Anatomical Pathology, South Western Area Pathology Service, Sydney, Australia.
authors.forename: Kasim
authors.initials: K
authors.lastname: Ismail
authors.affiliation: Department of Neurology, Liverpool Hospital, Sydney, Australia.
authors.forename: Neil
authors.initials: N
authors.lastname: Griffith
authors.affiliation: Department of Dermatology, Liverpool Hospital, Sydney, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Liu
authors.affiliation: Renal Unit, Liverpool Hospital, Sydney, Australia.
authors.forename: Angela
authors.initials: A
authors.lastname: Makris
keywords: acute renal failure; granulomatous interstitial nephritis; levetiracetam