title: Genetic association between VEGF polymorphisms and BRONJ in the Korean population.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF) polymorphisms and bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the Korean population.
  
  
  METHODS
  Forty-five individuals (2 men, 43 women; mean age: 68.7 ± 12.3 years) were recruited for this study. All visited the Yonsei University Dental Hospital for surgical intervention from January 2012 to January 2013 and had a history of bisphosphonate (BP) administration (oral and/or intravenous). Patients were allocated to case (n = 26) or control (n = 19) groups according to the patients' selection criteria. Association between three VEGF single nucleotide polymorphisms (rs699947 (-2578 C>A), rs2010963 (-634 G>C) and rs3025039 (+936 C>T)) and BRONJ were investigated using multiple logistic regression analysis and Fisher's exact test where appropriate (α = 0.05).
  
  
  RESULTS
  The CC homozygotes of rs2010963 and rs3025039 of VEGF gene were associated with an increased risk of BRONJ (P = 0.04, 0.03, respectively). In haplotype analysis, no differences in haplotype C-C (-2578/-634) and haplotype C-C-C (-2578/-634/+936) were observed.
  
  
  CONCLUSIONS
  The CC homozygotes of rs2010963 and rs3025039 polymorphisms in the VEGF gene were associated with an increased risk of BRONJ in the Korean population. Further epidemiological cohort studies with a larger sample size would be required to confirm the suggestive correlations.
authors.affiliation: Department of Prosthodontics, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: H
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: W
authors.initials: W
authors.lastname: Park
authors.affiliation: Department of Prosthodontics, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: J-H
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Prosthodontics, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: J-H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: bisphosphonate; bisphosphonate-related osteonecrosis of the jaw; gene polymorphisms; vascular endothelial growth factor