title: Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial.
abstract: Accumulating evidence suggests an association between gut microbiota and the development of obesity, raising the possibility of probiotic administration as a therapeutic approach. Bifidobacterium breve B-3 was found to exhibit an anti-obesity effect on high-fat diet-induced obesity mice. In the present study, a randomised, double-blind, placebo-controlled trial was conducted to evaluate the effect of the consumption of B. breve B-3 on body compositions and blood parameters in adults with a tendency for obesity. After a 4-week run-in period, the participants were randomised to receive either placebo or a B-3 capsule (approximately 5 × 10(10) colony-forming units of B-3/d) daily for 12 weeks. A significantly lowered fat mass was observed in the B-3 group compared with the placebo group at week 12. Improvements were observed for some blood parameters related to liver functions and inflammation, such as γ-glutamyltranspeptidase and high-sensitivity C-reactive protein. Significant correlations were found between the changed values of some blood parameters and the changed fat mass in the B-3 group. These results suggest the beneficial potential of B. breve B-3 in improving metabolic disorders.
authors.affiliation: Food Science and Technology Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Minami
authors.affiliation: Food Science and Technology Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Shizuki
authors.initials: S
authors.lastname: Kondo
authors.affiliation: Nutritional Science Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Naotake
authors.initials: N
authors.lastname: Yanagisawa
authors.affiliation: Food Science and Technology Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Odamaki
authors.affiliation: Food Science and Technology Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Jin-Zhong
authors.initials: JZ
authors.lastname: Xiao
authors.affiliation: Food Science and Technology Institute , Morinaga Milk Industry Co. Ltd , Zama , Kanagawa , Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Abe
authors.affiliation: NAKAJIMA Medical Clinic , Yokosuka , Kanagawa , Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: NAKAJIMA Medical Clinic , Yokosuka , Kanagawa , Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Hamamoto
authors.affiliation: Division of Healthcare Graduate School , Tokyo Healthcare University , Setagaya , Tokyo , Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Saitoh
authors.affiliation: Division of Healthcare Graduate School , Tokyo Healthcare University , Setagaya , Tokyo , Japan.
authors.forename: Taeko
authors.initials: T
authors.lastname: Shimoda
keywords: Bifidobacterium; DIO, diet-induced obesity; HbA1c, glycated Hb; LPS, lipopolysaccharide; Metabolic syndrome; Obesity; Randomised controlled trials; hCRP, high-sensitivity C-reactive protein; γ-GTP, γ-glutamyltranspeptidase