title: Well-designed bone-seeking radiolabeled compounds for diagnosis and therapy of bone metastases.
abstract: Bone-seeking radiopharmaceuticals are frequently used as diagnostic agents in nuclear medicine, because they can detect bone disorders before anatomical changes occur. Furthermore, their effectiveness in the palliation of metastatic bone cancer pain has been demonstrated in the clinical setting. With the aim of developing superior bone-seeking radiopharmaceuticals, many compounds have been designed, prepared, and evaluated. Here, several well-designed bone-seeking compounds used for diagnostic and therapeutic use, having the concept of radiometal complexes conjugated to carrier molecules to bone, are reviewed.
authors.affiliation: Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Kazuma
authors.identifier: 0000-0002-1691-7302
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
authors.forename: Atsushi
authors.identifier: 0000-0001-8750-1331
authors.initials: A
authors.lastname: Ishizaki
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009362:Neoplasm Metastasis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals