title: SYNTAX Score II predicts carotid disease in a multivessel coronary disease population.
abstract: BACKGROUND
  The SYNTAX Score (SxScore) is an angiographic tool that evaluates CAD complexity, which we previously reported lacking correlation with the presence of carotid disease. Recently, SxScore II has been developed including both angiographic and clinical variables, which could increase the prognostic accuracy for detection of carotid disease.
  
  
  RESULTS
  From January 2013 to June 2014, 244 patients with multivessel CAD (mean age 65.37 years, 84% males) underwent carotid ultrasound scan. At least one carotid lesion (CL) was found in 77% of patients with significant carotid disease (SCD) in 23.4% of cases. Logistic regression analysis revealed no relation between SxScore and CL/SCD (p=0.781 and p=0.368) while SxScore II well correlated with CL (SxScore II-PCI: odds ratio [OR] 1.036; 95% confidence interval [CI]:1.006-1.067; p=0.019; SxScore II-CABG: OR 1.045; 95% CI: 1.015-1.076, p=0.003) and SCD (SxScore II-PCI: OR 1.042; 95% CI: 1.012-1.073, p=0.006; SxScore-CABG: OR 1.054; 95% CI: 1.029-1.080, p<0.0001). The areas under the receiver-operating characteristic curves were: for SxScore 0.512 (95% CI: 0.448-0.577; p=0.77), for SxScore II-PCI and SxScore II-CABG 0.600 (95% CI: 0.536-0.662; p=0.01) and 0.645 (95% CI: 0.581-0.705; p=0.0008), respectively, and 0.527 (95% CI 0.462-0.591; p=0.56), 0.619 (95% CI: 0.555-0.681; p=0.01) and 0.681 (95% CI: 0.619-0.739; p=0.0001), respectively, for the identification of SCD.
  
  
  CONCLUSIONS
  The SxScore II, with inclusion of clinical variables over angiographic complexity, seems more suited to predict the presence of carotid disease than the SxScore.
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy. Electronic address: lucacost84@gmail.com.
authors.forename: Luca
authors.initials: L
authors.lastname: Costanzo
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Manichino
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Sole
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ronsivalle
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Pino
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Tamburino
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Giaimo
authors.affiliation: Cardiothoracovascular Department, Division of Angiology, Ferrarotto-Polyclinic Hospital, University of Catania, Via Santa Sofia 78, 95100 Catania, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003661:Decision Support Techniques; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D018615:Ultrasonography, Doppler, Color
keywords: Carotid artery ultrasound; Carotid lesion; Coronary artery disease; SYNTAX Score; SYNTAX Score II