title: Detection of low concentrations of ampicillin in milk.
abstract: Ampicillin, a common antibiotic, is detected at trace concentrations in milk using surface enhanced Raman spectroscopy in a microfluidic device, using less than 20 μL of sample, in 10 minutes, with minimal off-chip preparation. The device is configured so as to favor the interaction of the analyte with colloidal silver, and the optimization of the aggregation of the silver nanoparticles so as to increase the SERS intensity and the consequential sensitivity of analyte detection.
authors.affiliation: Institute of Collaborative Biotechnologies, University of California, Santa Barbara, California 93106, USA. meinhart@engineering.ucsb.edu.
authors.forename: Chrysafis
authors.initials: C
authors.lastname: Andreou
authors.forename: Rustin
authors.initials: R
authors.lastname: Mirsafavi
authors.forename: Martin
authors.initials: M
authors.lastname: Moskovits
authors.forename: Carl D
authors.initials: CD
authors.lastname: Meinhart
mesh_terms: D000667:Ampicillin / Q000032:analysis*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002417:Cattle; D004867:Equipment Design; D053768:Metal Nanoparticles / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000191:economics / Q000295:instrumentation*; D008892:Milk / Q000737:chemistry*; D018401:Sample Size; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D000667:Ampicillin