title: ZFIN, The zebrafish model organism database: Updates and new directions.
abstract: The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for genetic and genomic data from zebrafish (Danio rerio) research. ZFIN staff curate detailed information about genes, mutants, genotypes, reporter lines, sequences, constructs, antibodies, knockdown reagents, expression patterns, phenotypes, gene product function, and orthology from publications. Researchers can submit mutant, transgenic, expression, and phenotype data directly to ZFIN and use the ZFIN Community Wiki to share antibody and protocol information. Data can be accessed through topic-specific searches, a new site-wide search, and the data-mining resource ZebrafishMine (http://zebrafishmine.org). Data download and web service options are also available. ZFIN collaborates with major bioinformatics organizations to verify and integrate genomic sequence data, provide nomenclature support, establish reciprocal links, and participate in the development of standardized structured vocabularies (ontologies) used for data annotation and searching. ZFIN-curated gene, function, expression, and phenotype data are available for comparative exploration at several multi-species resources. The use of zebrafish as a model for human disease is increasing. ZFIN is supporting this growing area with three major projects: adding easy access to computed orthology data from gene pages, curating details of the gene expression pattern changes in mutant fish, and curating zebrafish models of human diseases.
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Leyla
authors.initials: L
authors.lastname: Ruzicka
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Bradford
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Ken
authors.initials: K
authors.lastname: Frazer
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Douglas G
authors.initials: DG
authors.lastname: Howe
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Holly
authors.initials: H
authors.lastname: Paddock
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramachandran
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Amy
authors.initials: A
authors.lastname: Singer
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Toro
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Ceri E
authors.initials: CE
authors.lastname: Van Slyke
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Eagle
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: David
authors.initials: D
authors.lastname: Fashena
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Patrick
authors.initials: P
authors.lastname: Kalita
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Knight
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Prita
authors.initials: P
authors.lastname: Mani
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Ryan
authors.initials: R
authors.lastname: Martin
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Sierra A T
authors.initials: SA
authors.lastname: Moxon
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Christian
authors.initials: C
authors.lastname: Pich
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Kevin
authors.initials: K
authors.lastname: Schaper
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Xiang
authors.initials: X
authors.lastname: Shao
authors.affiliation: ZFIN, 5291 University of Oregon, Eugene, Oregon.
authors.forename: Monte
authors.initials: M
authors.lastname: Westerfield
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods; D066289:Data Curation / Q000379:methods; D030541:Databases, Genetic; D056726:Genetic Association Studies; D023281:Genomics / Q000379:methods; D020407:Internet; D023421:Models, Animal; D015027:Zebrafish / Q000235:genetics*; D029961:Zebrafish Proteins / Q000235:genetics*
chemical_list: D029961:Zebrafish Proteins
keywords: curation; data mining; human disease models; ontology