title: [Beneficial effects of renal denervation on pulmonary vascular remodeling in experimental pulmonary artery hypertension].
abstract: OBJECTIVE
  To explore the effects of renal sympathetic denervation (RSD) on pulmonary vascular remodeling in a model of pulmonary arterial hypertension (PAH).
  
  
  METHODS
  According to the random number table, 24 beagles were randomized into control, PAH and PAH+RSD groups (n=8 each). The levels of neurohormone, echocardiogram and dynamics parameters were measured. Then 0.1 ml/kg dimethylformamide (control group) or 2 mg/kg dehydromonocrotaline (PAH and PAH+RSD groups) were injected. The PAH+RSD group underwent RSD after injection. At week 8 post-injection, the neurohormone levels, echocardiogram, dynamics parameters and pulmonary tissue morphology were observed.
  
  
  RESULTS
  The values of right ventricular systolic pressure (RVSP) and pulmonary arterial systolic pressure (PASP) in PAH and PAH+RSD groups were both significantly higher than those in control group ((42.8±8.7), (30.8±6.8) vs (23.2±5.7) mmHg (1 mmHg=0.133 kPa) and (45.1±11.2), (32.6±7.9) vs (24.7±7.1) mmHg). Meanwhile, the values of RVSP and PASP in PAH group were higher than those in PAH+RSD group (all P<0.01). The levels of serum angiotensin II (Ang II) and endothelin-1 significantly increased after 8 weeks in PAH dogs ((228±41) vs (113±34) pg/ml and (135±15) vs (77±7) pg/ml, all P<0.01). And Ang II and endothelin-1 were higher in lung tissues of PAH group ((65±10) and (96±10) pg/ml) than in those of control group ((38±7) and (54±6) pg/ml) and PAH+RSD group ((46±8) and (67±9) pg/ml) (all P<0.01). Pulmonary tissues had marked collagen hyperplasia and lamellar corpuscles of type 2 alveolar cells were damaged more severely in PAH dogs than in PAH+RSD dogs.
  
  
  CONCLUSIONS
  RSD suppresses pulmonary vascular remodeling and decreases pulmonary arterial pressure in experimental PAH. And the effect of RSD on PAH may contribute to decreased neurohormone levels.
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Shujuan
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China; Email: ruyan71@163.com.
authors.forename: Qingyan
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Zixuan
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Xiaozhan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Xule
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Zongwen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Shengbo
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Congxin
authors.initials: C
authors.lastname: Huang
mesh_terms: D000804:Angiotensin II; D000818:Animals; D001794:Blood Pressure; D003714:Denervation; D004285:Dogs; D004452:Echocardiography; D019332:Endothelin-1; D065627:Familial Primary Pulmonary Hypertension; D006976:Hypertension, Pulmonary; D007668:Kidney; D008168:Lung; D016686:Monocrotaline / Q000031:analogs & derivatives; D011651:Pulmonary Artery; D013562:Sympathectomy; D066253:Vascular Remodeling
chemical_list: D019332:Endothelin-1; D000804:Angiotensin II; C014114:monocrotaline pyrrole; D016686:Monocrotaline