title: Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis.
abstract: OBJECTIVE
  To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD).
  
  
  METHODS
  In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified.
  
  
  RESULTS
  Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P < 0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P = 0.003) and + RF (P = 0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P = 0.02) and with fibrosis score DD (P = 0.01), anti-CCP2 titers (P < 0.001), and MTX treatment duration (P < 0.001).
  
  
  CONCLUSIONS
  Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD.
authors.affiliation: Centro Universitario de Tonalá (CUTONALA), Universidad de Guadalajara (U de G), 48525 Tonala, JAL, Mexico.
authors.forename: Alberto Daniel
authors.identifier: 0000-0002-1173-1736
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.affiliation: Programa de Becarios de Investigación del Instituto Mexicano del Seguro Social (IMSS) y Programa de Doctorado en Farmacología, . Centro Universitario de Ciencias de la Salud (CUCS), U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ponce-Guarneros
authors.affiliation: Unidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, Mexico ; Programa de Doctorado en Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Jorge Ivan
authors.identifier: 0000-0003-0001-3787
authors.initials: JI
authors.lastname: Gamez-Nava
authors.affiliation: Hospital General Regional-180, IMSS, 45650 Tlajomulco, JAL, Mexico.
authors.forename: Eva Maria
authors.identifier: 0000-0001-7192-9667
authors.initials: EM
authors.lastname: Olivas-Flores
authors.affiliation: Instituto Nacional de Enfermedades Respiratorias "Dr. Ismael Cosío Villegas" (INER), 14080 Mexico City, DF, Mexico.
authors.forename: Mayra
authors.initials: M
authors.lastname: Mejía
authors.affiliation: Departamento de Medicina Interna-Reumatología y Departamento de Medicina Interna-Neumología, HGR-110, IMSS, 44700 Guadalajara, JAL, Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: Juárez-Contreras
authors.affiliation: Departamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico ; Instituto de Investigacion en Reumatologia y del Sistema Musculoesqueletico, CUCS and Division de Medicina Interna, Servicio de Reumatologia OPD Hospital Civil Dr. Juan I Menchaca, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Erika Aurora
authors.identifier: 0000-0001-6486-1086
authors.initials: EA
authors.lastname: Martínez-García
authors.affiliation: Departamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico ; Instituto de Investigacion en Reumatologia y del Sistema Musculoesqueletico, CUCS and Division de Medicina Interna, Servicio de Reumatologia OPD Hospital Civil Dr. Juan I Menchaca, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Esther Guadalupe
authors.initials: EG
authors.lastname: Corona-Sánchez
authors.affiliation: Programa de Servicio Social en Investigación, Secretaria de Salud (SSA), 11570 Mexico City, DF, Mexico.
authors.forename: Tania Marlen
authors.initials: TM
authors.lastname: Rodríguez-Hernández
authors.affiliation: Instituto de Investigacion en Reumatologia y del Sistema Musculoesqueletico, CUCS and Division de Medicina Interna, Servicio de Reumatologia OPD Hospital Civil Dr. Juan I Menchaca, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Mónica
authors.identifier: 0000-0002-3823-4676
authors.initials: M
authors.lastname: Vázquez-del Mercado
authors.affiliation: Unidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, Mexico ; Departamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Páramo
authors.affiliation: Unidad de Investigación en Epidemiología Clínica y División de Investigación en Salud Unidad Medica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), 44340 Guadalajara, JAL, Mexico ; Programa Internacional de Medicina, Universidad Autónoma de Guadalajara (UAG), 44670 Guadalajara, JAL, Mexico ; Servicio de Medicina Interna, Departamento de Inmunología y Reumatología, Hospital General de Occidente, Secretaría de Salud Jalisco, 45170 Zapopan, JAL, Mexico.
authors.forename: Arnulfo Hernan
authors.identifier: 0000-0003-3061-521X
authors.initials: AH
authors.lastname: Nava-Zavala
authors.affiliation: Departamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Ernesto German
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.affiliation: Programa de Doctorado en Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, Mexico ; Dirección de la División de Disciplinas para el Desarrollo, Promoción y Preservación de la Salud, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Celis
authors.affiliation: Programa de Doctorado en Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, Mexico ; Departamento de Medicina Interna-Reumatología y Departamento de Medicina Interna-Neumología, HGR-110, IMSS, 44700 Guadalajara, JAL, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: González-Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000276:immunology*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000276:immunology / Q000473:pathology; D005260:Female; D005355:Fibrosis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000276:immunology* / Q000473:pathology*; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000906:Antibodies; D018501:Antirheumatic Agents; D015415:Biomarkers; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D008727:Methotrexate