title: Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.
abstract: Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.
authors.affiliation: Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavík, Iceland.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Sahariah
authors.forename: Kasper K
authors.initials: KK
authors.lastname: Sørensen
authors.forename: Martha Á
authors.initials: MÁ
authors.lastname: Hjálmarsdóttir
authors.forename: Ólafur E
authors.initials: ÓE
authors.lastname: Sigurjónsson
authors.forename: Knud J
authors.initials: KJ
authors.lastname: Jensen
authors.forename: Már
authors.initials: M
authors.lastname: Másson
authors.forename: Mikkel B
authors.initials: MB
authors.lastname: Thygesen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D017646:Organosilicon Compounds / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014862:Wasp Venoms / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D017646:Organosilicon Compounds; D014862:Wasp Venoms; C443041:anoplin; C009660:t-butyldimethylsilyl compounds; D048271:Chitosan