title: Interaction of H2S with Calcium Permeable Channels and Transporters.
abstract: A growing amount of evidence has suggested that hydrogen sulfide (H2S), as a gasotransmitter, is involved in intensive physiological and pathological processes. More and more research groups have found that H2S mediates diverse cellular biological functions related to regulating intracellular calcium concentration. These groups have demonstrated the reciprocal interaction between H2S and calcium ion channels and transporters, such as L-type calcium channels (LTCC), T-type calcium channels (TTCC), sodium/calcium exchangers (NCX), transient receptor potential (TRP) channels, β-adrenergic receptors, and N-methyl-D-aspartate receptors (NMDAR) in different cells. However, the understanding of the molecular targets and mechanisms is incomplete. Recently, some research groups demonstrated that H2S modulates the activity of calcium ion channels through protein S-sulfhydration and polysulfide reactions. In this review, we elucidate that H2S controls intracellular calcium homeostasis and the underlying mechanisms.
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Harbin, Heilongjiang 150086, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xu
authors.affiliation: The School of Kinesiology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1.
authors.forename: Guangdong
authors.identifier: 0000-0002-1381-2134
authors.initials: G
authors.lastname: Yang
authors.affiliation: Department of Health Sciences, Lakehead University, Thunder Bay, ON, Canada P7B 5E1.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Biology, Lakehead University, Thunder Bay, ON, Canada P7B 5E1.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D002463:Cell Membrane Permeability; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D015220:Calcium Channels; D026901:Membrane Transport Proteins; D006862:Hydrogen Sulfide