title: Complementing T Cells' Functions: Bringing in Metabolism Matters.
abstract: Components of the complement system act directly on T cells to alter conventional and regulatory T cell subsets. In this issue of Immunity, Kolev, Dimeloe, Le Friec et al. (2015) provide evidence of a mechanism by which the complement stimulates sustained mTORC1 activation and regulates cellular metabolism.
authors.affiliation: Program in Immunology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA; Department of Medicine, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA; Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA. Electronic address: mark.boothby@vanderbilt.edu.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Boothby
authors.affiliation: Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA.
authors.forename: Ariel L
authors.initials: AL
authors.lastname: Raybuck
authors.affiliation: Program in Immunology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA; Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37232-2363, USA.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Cho
mesh_terms: D003165:Complement System Proteins / Q000276:immunology*; D006463:Hemolytic-Uremic Syndrome / Q000276:immunology*; D006801:Humans; D027283:Large Neutral Amino Acid-Transporter 1 / Q000378:metabolism*; D051916:Membrane Cofactor Protein / Q000378:metabolism*; D018417:Th1 Cells / Q000502:physiology*
chemical_list: D027283:Large Neutral Amino Acid-Transporter 1; D051916:Membrane Cofactor Protein; D003165:Complement System Proteins