title: The transitioning from conventional therapy to biological treatment in psoriatic patients: STRATOS, a project of Marche Region.
abstract: BACKGROUND
  STRATOS is the acronym of the "STRuctured Approach to the Treatment of psOriatic patientS". The optimization of the psoriasis's therapeutic management is one of the most important goals for dermatologists. According to Mrowietz's consensus report, the transitioning from conventional therapy to biological therapy is mainly due to the lack/loss of efficacy and/or for safety reasons. The aim of the manuscript was to describe the principal results obtained by the Dermatologic Clinic of Polytechnic University of Marche Region and the Units of Dermatology of the Marche Region applying, in our regional reality, Mrowietz's protocol for the daily management of patients with moderate-to-severe plaque.
  
  
  METHODS
  Forty-seven patients with moderate to severe chronic plaque psoriasis have been monitored during the six-months study period.
  
  
  RESULTS
  Psoriatic patients with diabetes showed further concomitant comorbidities compared to non-diabetics, as hypertension and hypercholesterolemia. Moreover, based on WHO classification, overweight was diagnosed in female patients, whereas obesity was prevalent in male patients. This aspect confirms the strict link between the multifaceted aspects of psoriatic patient which is primarily related to the persistent low-grade inflammation. In our psoriatic group, 10% of monitored patients were affected by Crohn disease or ulcerative colitis.
  
  
  CONCLUSIONS
  The Mrowietz's transitioning protocol is a useful, reliable and feasible tool to manage the therapeutic iter of psoriatic patients in an Italian clinical setting also at regional level.
authors.affiliation: Department of Clinical and Molecular Sciences, Dermatological Clinic, Marche Polytechnic University, Ancona, Italy - giulia.ganzetti@alice.it.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ganzetti
authors.forename: Anna
authors.initials: A
authors.lastname: Campanati
authors.forename: Maria L
authors.initials: ML
authors.lastname: Bernardini
authors.forename: Alberta
authors.initials: A
authors.lastname: Bettacchi
authors.forename: Giuliano
authors.initials: G
authors.lastname: Brandozzi
authors.forename: Valerio
authors.initials: V
authors.lastname: Brisigotti
authors.forename: Ivana
authors.initials: I
authors.lastname: Cataldi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Filosa
authors.forename: Alfredo
authors.initials: A
authors.lastname: Giacchetti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lemme
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Morresi
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Nicolini
authors.forename: Valentina
authors.initials: V
authors.lastname: Postacchini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ricotti
authors.forename: Laura
authors.initials: L
authors.lastname: Rosa
authors.forename: Marco
authors.initials: M
authors.lastname: Simonacci
authors.forename: Annamaria
authors.initials: A
authors.lastname: Offidani
mesh_terms: D000328:Adult; D001691:Biological Therapy / Q000379:methods*; D003093:Colitis, Ulcerative / Q000453:epidemiology; D015897:Comorbidity; D003424:Crohn Disease / Q000453:epidemiology; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D003879:Dermatologic Agents