title: Accurate Classification of Chronic Migraine via Brain Magnetic Resonance Imaging.
abstract: BACKGROUND
  The International Classification of Headache Disorders provides criteria for the diagnosis and subclassification of migraine. Since there is no objective gold standard by which to test these diagnostic criteria, the criteria are based on the consensus opinion of content experts. Accurate migraine classifiers consisting of brain structural measures could serve as an objective gold standard by which to test and revise diagnostic criteria. The objectives of this study were to utilize magnetic resonance imaging measures of brain structure for constructing classifiers: (1) that accurately identify individuals as having chronic vs episodic migraine vs being a healthy control; and (2) that test the currently used threshold of 15 headache days/month for differentiating chronic migraine from episodic migraine.
  
  
  METHODS
  Study participants underwent magnetic resonance imaging for determination of regional cortical thickness, cortical surface area, and volume. Principal components analysis combined structural measurements into principal components accounting for 85% of variability in brain structure. Models consisting of these principal components were developed to achieve the classification objectives. Tenfold cross validation assessed classification accuracy within each of the 10 runs, with data from 90% of participants randomly selected for classifier development and data from the remaining 10% of participants used to test classification performance. Headache frequency thresholds ranging from 5-15 headache days/month were evaluated to determine the threshold allowing for the most accurate subclassification of individuals into lower and higher frequency subgroups.
  
  
  RESULTS
  Participants were 66 migraineurs and 54 healthy controls, 75.8% female, with an average age of 36 +/- 11 years. Average classifier accuracies were: (1) 68% for migraine (episodic + chronic) vs. healthy controls; (2) 67.2% for episodic migraine vs healthy controls; (3) 86.3% for chronic migraine vs. healthy controls; and (4) 84.2% for chronic migraine vs episodic migraine. The classifiers contained principal components consisting of several structural measures, commonly including the temporal pole, anterior cingulate cortex, superior temporal lobe, entorhinal cortex, medial orbital frontal gyrus, and pars triangularis. A threshold of 15 headache days/month allowed for the most accurate subclassification of migraineurs into lower frequency and higher frequency subgroups.
  
  
  CONCLUSIONS
  Classifiers consisting of cortical surface area, cortical thickness, and regional volumes were highly accurate for determining if individuals have chronic migraine. Furthermore, results provide objective support for the current use of 15 headache days/month as a threshold for dividing migraineurs into lower frequency (i.e., episodic migraine) and higher frequency (i.e., chronic migraine) subgroups.
authors.affiliation: Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Schwedt
authors.affiliation: Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Catherine D
authors.initials: CD
authors.lastname: Chong
authors.affiliation: School of Computing, Informatics, Decision Systems Engineering, Arizona State University, Phoenix, AZ, USA.
authors.forename: Teresa
authors.initials: T
authors.lastname: Wu
authors.affiliation: School of Computing, Informatics, Decision Systems Engineering, Arizona State University, Phoenix, AZ, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Gaw
authors.affiliation: School of Computing, Informatics, Decision Systems Engineering, Arizona State University, Phoenix, AZ, USA.
authors.forename: Yinlin
authors.initials: Y
authors.lastname: Fu
authors.affiliation: School of Computing, Informatics, Decision Systems Engineering, Arizona State University, Phoenix, AZ, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification* / Q000175:diagnosis*; D025341:Principal Component Analysis; D057566:Self Report / Q000592:standards
keywords: cortical surface area; cortical thickness; diagnostic classifier; magnetic resonance imaging; migraine