title: Synchronous occurrence of ileal stromal tumor (GIST) and colonic adenocarcinoma: a case report.
abstract: BACKGROUND
  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. There is an increasing number of literature reports on synchronous occurrence of gastrointestinal stromal tumors and another malignancy of distinct etiology and evolution. The most reported cases include gastric synchronous occurrence of gastrointestinal stromal tumors and adenocarcinoma and gastric gastrointestinal stromal tumors and colonic adenocarcinoma.
  
  
  METHODS
  We present a case of a 77-old female, with synchronous cecal moderately differentiated adenocarcinoma in Stage IIA according to the TNM classification and ileal spindle cell type GIST with low malignant potential, positive for c-Kit, CD34, vimentin, Actin, and negative for S100.
  
  
  CONCLUSIONS
  The synchronous occurrence of small bowel gastrointestinal stromal tumors and other primary gastrointestinal malignancies has been rarely reported. There is a need of further investigations to identify the relationship between gastrointestinal stromal tumors and colorectal cancers.
authors.affiliation: Department of Pathology, PHO Clinical Hospital - Tetovo, Tetovo, R. Macedonia.
authors.forename: E
authors.initials: E
authors.lastname: Trajkovska
authors.affiliation: Institute of Pathology, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: V
authors.initials: V
authors.lastname: Janevska
authors.affiliation: Institute of Pathology, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: L
authors.initials: L
authors.lastname: Spasevska
authors.affiliation: University Clinic of Abdominal Surgery, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: V
authors.initials: V
authors.lastname: Janevski
authors.affiliation: Institute of Anatomy, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: J
authors.initials: J
authors.lastname: Zhivadinovik
authors.affiliation: Institute of Pathology, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: G
authors.initials: G
authors.lastname: Petrushevska
authors.affiliation: Institute of Pathology, Faculty of Medicine, Skopje, R. Macedonia.
authors.forename: B
authors.initials: B
authors.lastname: Dukova
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D002430:Cecal Neoplasms / Q000473:pathology*; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D009378:Neoplasms, Multiple Primary