title: Effects of blood-flow-restricted resistance training on muscle function in a 74-year-old male with sporadic inclusion body myositis: a case report.
abstract: Sporadic inclusion body myositis (sIBM) is a systemic disease that is characterized by substantial skeletal muscle weakness and muscle inflammation, leading to impaired physical function. The objective was to investigate the effect of low-load resistance exercise with concurrent partial blood flow restriction to the working muscles (blood-flow-restricted (BFR) training) in a patient with sIBM. The training consisted of 12 weeks of lower extremity BFR training with low training loads (~25-RM). The patient was tested for mechanical muscle function and functional capacity before and after 6 and 12 weeks of training. Maximal horizontal gait speed increased by 19%, which was accompanied by 38-92% improvements in mechanical muscle function (maximal isometric strength, rate of force development and muscle power). In conclusion, BFR training was well tolerated by the patient with sIBM and led to substantial improvements in mechanical muscle function and gait speed.
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle research Cluster (SMRC), University of Southern Denmark, Odense, Denmark. ajoergensen@health.sdu.dk.|Department of Clinical Research, University of Southern Denmark, Odense, Denmark. ajoergensen@health.sdu.dk.
authors.forename: A N
authors.identifier: http://orcid.org/0000-0001-7330-8637
authors.initials: AN
authors.lastname: Jørgensen
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle research Cluster (SMRC), University of Southern Denmark, Odense, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Aagaard
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle research Cluster (SMRC), University of Southern Denmark, Odense, Denmark.
authors.forename: J L
authors.initials: JL
authors.lastname: Nielsen
authors.affiliation: Department of Sports Science and Clinical Biomechanics, SDU Muscle research Cluster (SMRC), University of Southern Denmark, Odense, Denmark.
authors.forename: U
authors.initials: U
authors.lastname: Frandsen
authors.affiliation: Department of Clinical Research, University of Southern Denmark, Odense, Denmark.|Department of Rheumatology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: L P
authors.initials: LP
authors.lastname: Diederichsen
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D005080:Exercise Test; D005684:Gait; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000098:blood supply*; D018979:Myositis, Inclusion Body / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D020127:Recovery of Function; D012039:Regional Blood Flow; D055070:Resistance Training / Q000379:methods*; D013997:Time Factors; D014111:Tourniquets; D016896:Treatment Outcome
keywords: blood-flow-restricted training; functional capacity; inflammatory myopathy; muscle power; muscle strength; rate of force development