title: Interactions between childhood maltreatment and brain-derived neurotrophic factor and serotonin transporter polymorphisms on depression symptoms.
abstract: This study represents the first replication of the BDNF Val66Met ⁎ 5-HTTLPR ⁎ childhood maltreatment effect on self-reported depression symptoms using a rigorous maltreatment interview. Participants included a community sample of 339 adolescents/young adults (age 12-33; 265 female). In the context of childhood neglect, among BDNF Met-carriers, s-allele carriers of 5-HTTLPR reported significantly higher depression than l/l homozygotes, whereas a differential relation of 5-HTTLPR genotype to depression was not seen among BDNF Val/Val homozygotes.
authors.affiliation: Queen׳s University, Department of Psychology, Kingston, ON, Canada. Electronic address: harkness@queensu.ca.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Harkness
authors.affiliation: Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Strauss
authors.affiliation: University of Toronto, Department of Psychology, Toronto, ON, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Michael Bagby
authors.affiliation: Queen׳s University, Department of Psychology, Kingston, ON, Canada.
authors.forename: Jeremy G
authors.initials: JG
authors.lastname: Stewart
authors.affiliation: Queen׳s University, Department of Psychology, Kingston, ON, Canada.
authors.forename: Cherie
authors.initials: C
authors.lastname: Larocque
authors.affiliation: Queen׳s University, Department of Psychology, Kingston, ON, Canada.
authors.forename: Raegan
authors.initials: R
authors.lastname: Mazurka
authors.affiliation: Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
authors.forename: Arun
authors.initials: A
authors.lastname: Ravindran
authors.affiliation: University of Calgary, Department of Veterinary Medicine, Calgary, AB, Canada.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Wynne-Edwards
authors.affiliation: Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON, Canada.
authors.forename: Neil A
authors.initials: NA
authors.lastname: Rector
authors.affiliation: Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
authors.forename: James
authors.initials: J
authors.lastname: Kennedy
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002649:Child Abuse / Q000523:psychology*; D003863:Depression / Q000235:genetics* / Q000523:psychology*; D004843:Epistasis, Genetic / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C579455:BDNF protein, human
keywords: BDNF gene; Depression; Serotonin transporter gene