title: Nonotogenic Skull Base Osteomyelitis in Children: Two Cases and a Review of the Literature.
abstract: Skull base osteomyelitis is a rare condition in childhood and can be described according to whether it is associated with spread of infection from the middle ear (otogenic) or not (nonotogenic). Early recognition of this serious disease and prompt treatment are key to preventing extension to adjacent vascular and nervous system structures. Diagnosis can be challenging due to the variable presentation of the disease and potentially subtle radiological appearances. We present 2 cases of nonotogenic skull base osteomyelitis in childhood both affecting the clivus and review the 6 cases previously described. Both children presented with fever, headache and neck stiffness and responded well to medical management alone; detailed imaging was key to making a diagnosis.
authors.affiliation: From the *Paediatric Infectious Diseases and Immunology, University Department of Paediatrics, Oxford, United Kingdom; †Department of Neuroradiology, and ‡Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: Johannes
authors.initials: J
authors.lastname: Trück
authors.forename: Ameeka
authors.initials: A
authors.lastname: Thompson
authors.forename: Reena
authors.initials: R
authors.lastname: Dwivedi
authors.forename: Shelley
authors.initials: S
authors.lastname: Segal
authors.forename: Geetha
authors.initials: G
authors.lastname: Anand
authors.forename: Dominic F
authors.initials: DF
authors.lastname: Kelly
mesh_terms: D002648:Child; D003388:Cranial Fossa, Posterior / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000473:pathology*; D011859:Radiography; D019291:Skull Base / Q000000981:diagnostic imaging / Q000473:pathology*