title: Photopolymerized micelles of diacetylene amphiphile: physical characterization and cell delivery properties.
abstract: A series of polydiacetylene (PDA) - based micelles were prepared from diacetylenic surfactant bearing polyethylene glycol, by increasing UV-irradiation times. These polymeric lipid micelles were analyzed by physicochemical methods, electron microscopy and NMR analysis. Cellular delivery of fluorescent dye suggests that adjusting the polymerization state is vital to reach the full in vitro potential of PDA-based delivery systems.
authors.affiliation: Laboratory of Functional Chemo Systems, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. alwag@unistra.fr.|Laboratory V-SAT, Vectors - Synthesis and Therapeutic Applications, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. remy@unistra.fr.
authors.forename: Patrick
authors.initials: P
authors.lastname: Neuberg
authors.affiliation: Laboratory of Functional Chemo Systems, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. alwag@unistra.fr.
authors.forename: Aurélia
authors.initials: A
authors.lastname: Perino
authors.affiliation: Laboratory of Functional Chemo Systems, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. alwag@unistra.fr.|Laboratory V-SAT, Vectors - Synthesis and Therapeutic Applications, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. remy@unistra.fr.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Morin-Picardat
authors.affiliation: Laboratory of Biogalenic Pharmacy, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.affiliation: Laboratory of Biophotonic and Pharmacology, UMR 7213, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Darwich
authors.affiliation: Phytodia SAS, Boulevard Sébastien Brant, 67412 Illkirch, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Weltin
authors.affiliation: Laboratory of Biophotonic and Pharmacology, UMR 7213, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Mely
authors.affiliation: Laboratory of Biophotonic and Pharmacology, UMR 7213, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France.
authors.forename: Andrey S
authors.initials: AS
authors.lastname: Klymchenko
authors.affiliation: Laboratory V-SAT, Vectors - Synthesis and Therapeutic Applications, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. remy@unistra.fr.
authors.forename: Jean-Serge
authors.initials: JS
authors.lastname: Remy
authors.affiliation: Laboratory of Functional Chemo Systems, and Labex Medalis, CAMB, UMR 7199 CNRS, Faculty of Pharmacy, University of Strasbourg, 74 route du Rhin, 67401 Illkirch, France. alwag@unistra.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Wagner
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D010078:Oxazines / Q000008:administration & dosage / Q000737:chemistry; D000078789:Polyacetylene Polymer; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects; D058105:Polymerization; D011108:Polymers / Q000737:chemistry* / Q000528:radiation effects; D053279:Polyynes / Q000737:chemistry* / Q000528:radiation effects; D013501:Surface-Active Agents / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D005456:Fluorescent Dyes; D008823:Micelles; D010078:Oxazines; D000078789:Polyacetylene Polymer; D011108:Polymers; D013501:Surface-Active Agents; D053279:Polyynes; C082361:polydiacetylene; D011092:Polyethylene Glycols; C044808:nile red