title: ER Stress in Dendritic Cells Promotes Cancer.
abstract: XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA; Graduate Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Garris
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital Research Institute and Harvard Medical School, Boston, MA 02114, USA. Electronic address: mpittet@mgh.harvard.edu.
authors.forename: Mikael J
authors.initials: MJ
authors.lastname: Pittet
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003713:Dendritic Cells / Q000473:pathology*; D059865:Endoplasmic Reticulum Stress; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors