title: Advances in SPECT for Optimizing the Liver Tumors Radioembolization Using Yttrium-90 Microspheres.
abstract: Radioembolization (RE) with Yttrium-90 ((90)Y) microspheres is an effective treatment for unresectable liver tumors. The activity of the microspheres to be administered should be calculated based on the type of microspheres. Technetium-99m macroaggregated albumin ((99m)Tc-MAA) single photon emission computed tomography/computed tomography (SPECT/CT) is a reliable assessment before RE to ensure the safe delivery of microspheres into the target. (90)Y bremsstrahlung SPECT imaging as a posttherapeutic assessment approach enables the reliable determination of absorbed dose, which is indispensable for the verification of treatment efficacy. This article intends to provide a review of the methods of optimizing (90)Y bremsstrahlung SPECT imaging to improve the treatment efficacy of liver tumor RE using (90)Y microspheres.
authors.affiliation: Department of Medical Physics, Nuclear Medicine Unit, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hoda Rezaei
authors.initials: HR
authors.lastname: Roshan
authors.affiliation: Department of Medical Physics, Nuclear Medicine Unit, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ahmadreza
authors.initials: A
authors.lastname: Azarm
authors.affiliation: Department of Radiology, Nuclear Medicine Unit, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Mahmoudian
authors.affiliation: Department of Medical Physics, Nuclear Medicine Unit, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Jalil Pirayesh
authors.initials: JP
authors.lastname: Islamian
keywords: Bremsstrahlung SPECT; Yttrium-90 microspheres; radioembolization; single photon emission computed tomography/computed tomography