title: The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B.
abstract: BACKGROUND
  In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology.
  
  
  METHODS
  PET imaging with carbon 11-labeled Pittsburgh compound B examined the pattern of amyloid-β deposition in 68 nondemented adults with DS (30-53 years) to determine the relationship between deposition and normal aging. Standard uptake value ratio (SUVR) images were created with cerebellar gray matter as the reference region.
  
  
  RESULTS
  Multiple linear regression revealed slight but highly significant (corrected P < .05) positive correlations between SUVR and age. The striatum showed the strongest correlation, followed by precuneus, parietal cortex, anterior cingulate, frontal cortex, and temporal cortex.
  
  
  CONCLUSIONS
  There is an age-related amyloid-β deposition in the DS population, but as a pattern of elevated cortical retention becomes apparent, the correlation of SUVR with age ceases to be significant. Factors unrelated to aging may drive an increase in deposition during early Alzheimer's disease pathogenesis.
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Lao
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Tobey J
authors.initials: TJ
authors.lastname: Betthauser
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Ansel T
authors.initials: AT
authors.lastname: Hillmer
authors.affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Julie C
authors.initials: JC
authors.lastname: Price
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Klunk
authors.affiliation: Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Iulia
authors.initials: I
authors.lastname: Mihaila
authors.affiliation: Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Higgins
authors.affiliation: Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Bulova
authors.affiliation: Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Sigan L
authors.initials: SL
authors.lastname: Hartley
authors.affiliation: Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Regina
authors.initials: R
authors.lastname: Hardison
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Rameshwari V
authors.initials: RV
authors.lastname: Tumuluru
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Dhanabalan
authors.initials: D
authors.lastname: Murali
authors.affiliation: Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Chester A
authors.initials: CA
authors.lastname: Mathis
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Annie D
authors.initials: AD
authors.lastname: Cohen
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Todd E
authors.initials: TE
authors.lastname: Barnhart
authors.affiliation: New York State Institute for Basic Research in Developmental Disabilities, Albany, NY, USA.
authors.forename: Darlynne A
authors.initials: DA
authors.lastname: Devenny
authors.affiliation: Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Marsha R
authors.initials: MR
authors.lastname: Mailick
authors.affiliation: Department of Medicine-Geriatrics, University of Wisconsin Madison, Madison, WI, USA.
authors.forename: Sterling C
authors.initials: SC
authors.lastname: Johnson
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Handen
authors.affiliation: Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin Madison, Madison, WI, USA. Electronic address: bchristian@wisc.edu.
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Christian
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism*; D000814:Aniline Compounds; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002250:Carbon Radioisotopes; D015331:Cohort Studies; D004314:Down Syndrome / Q000000981:diagnostic imaging* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D001057:Apolipoproteins E; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles
keywords: Aging; Alzheimer's disease; Amyloid imaging; Down syndrome; PiB