title: Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction.
abstract: BACKGROUND
  Fibroblast growth factor 21 (FGF21) has been described as a metabolic hormone critical for glucose and lipid metabolism. Previously, high levels of FGF21 were observed in patients with coronary heart disease and non-acute myocardial infarction (non-AMI). In this study, we investigated the changes in FGF21 levels in Chinese patients with AMI.
  
  
  RESULTS
  We used ELISA to measure circulating FGF21 levels in 55 AMI patients and 45 non-AMI control patients on the 1st day after syndrome onset. All patients were followed-up within 30 days. FGF21 levels in AMI patients were significantly higher than those in non-AMI controls (0.25 (0.16-0.34) vs. 0.14 (0.11-0.20) ng/mL, P < 0.001). FGF21 levels reached the maximum within approximately 24 h after the onset of AMI and remained at high for 7 days, and the FGF21 level (OR: 16.93; 95% confidence interval (CI): 2.65-108.05; P = 0.003) was identified as an independent factor associated with the presence of AMI. On the 7th day, FGF21 levels were significantly higher in the patients who subsequently developed re-infarction within 30 days than in the patients who did not develop re-infarction (with vs. without re-infarction: 0.45 (0.22-0.64) vs. 0.21 (0.15-0.29) ng/mL, P = 0.014).
  
  
  CONCLUSIONS
  The level of serum FGF21 is independently associated with the presence of AMI in Chinese patients. High FGF21 levels might be related to the incidence of re-infarction within 30 days after onset.
authors.affiliation: Department of Cardiology, Beijing Hospital, China Ministry of Health, Beijing, P.R.China.
authors.forename: Wenduo
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, P.R.China.
authors.forename: Songyun
authors.initials: S
authors.lastname: Chu
authors.affiliation: Department of Cardiology, Peking University First Hospital, Beijing, P.R.China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Beijing Hospital, China Ministry of Health, Beijing, P.R.China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D015596:Nutrition Assessment; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors