title: Successful Treatment with Infliximab for Refractory Uveitis in a Hemodialysis Patient with Behçet's Disease and a Review of the Literature for Infliximab Use in Patients on Hemodialysis.
abstract: A 36-year-old man with a 16-year history of refractory Behçet's disease (BD)-associated uveitis and chronic renal failure requiring hemodialysis suffered from frequent ocular attacks despite treatment with systemic corticosteroids and cyclosporine A. Following infliximab administration, the patient's BD ocular attack score 24 and visual acuity improved. Although he developed mild acute gastroenteritis, he did not experience any other adverse events. In our review of the literature, we identified seven patients on hemodialysis with inflammatory disease successfully treated with infliximab. Infliximab may be effective and safe in cases of BD and other diseases, including in patients under hemodialysis.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Kurata
authors.forename: Hiroto
authors.initials: H
authors.lastname: Tsuboi
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takahashi
authors.forename: Saori
authors.initials: S
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ebe
authors.forename: Shinya
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Naoto
authors.initials: N
authors.lastname: Umeda
authors.forename: Yuya
authors.initials: Y
authors.lastname: Kondo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogishima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Isao
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Sujin
authors.initials: S
authors.lastname: Hoshi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oshika
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sumida
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology; D016572:Cyclosporine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D000069285:Infliximab / Q000627:therapeutic use*; D008297:Male; D006435:Renal Dialysis; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy* / Q000276:immunology; D014792:Visual Acuity
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D016572:Cyclosporine; D000069285:Infliximab