title: Improvement in chronic low back pain in an obese patient with topiramate use.
abstract: The objective of this study was to demonstrate efficacy, benefit, and potential use of topiramate in treating obese patients with chronic low back pain. This is a case report from an outpatient academic pain multidisciplinary clinical center. The patient was a 30-year-old morbidly obese (body mass index [BMI]: 61.4 kg/m(2)) female suffering from chronic low back pain. With a known association between obesity and chronic low back pain, and a possible role of topiramate in treating both simultaneously, the patient was started on a therapeutic trial of topiramate. Over a period of a 12-week topiramate therapy, the patient experienced clinically meaningful and significant weight loss as well as improvement in her chronic low back pain and functionality. With more substantial evidence, pain physicians may start considering using topiramate in the multimodal management of obesity-related chronic low back pain based on their thoughtful consideration of the drug's efficacy and side effects and the patient's comorbidities and preferences.
authors.forename: Anita
authors.initials: A
authors.lastname: Gupta
authors.forename: Archana
authors.initials: A
authors.lastname: Kulkarni
authors.forename: Vendhan
authors.initials: V
authors.lastname: Ramanujam
authors.forename: Lu
authors.initials: L
authors.lastname: Zheng
authors.forename: Erin
authors.initials: E
authors.lastname: Treacy
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D017116:Low Back Pain / Q000188:drug therapy* / Q000209:etiology; D009767:Obesity, Morbid / Q000150:complications*; D000077236:Topiramate
chemical_list: D019440:Anti-Obesity Agents; D000077236:Topiramate; D005632:Fructose
keywords: chronic low back pain; efficacy and weight decrease; obesity; topiramate