title: Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity.
abstract: Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.
authors.affiliation: Department of Microbial Infection and Immunity, The Ohio State University, 460 West 12 Ave., Columbus, OH 43210.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Microbial Infection and Immunity, The Ohio State University, 460 West 12 Ave., Columbus, OH 43210.
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia 6009, Australia.
authors.forename: Wallace Y
authors.initials: WY
authors.lastname: Langdon
keywords: Cbl-b; NK cells; T cell tolerance; asthma; autoimmunity; cancer; proallergic T cells