title: Bifurcation in Cell Cycle Dynamics Regulated by p53.
abstract: We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases. The IR induced p53 dynamics undergo collapse of oscillation with collapse time Δt which depends on IR strength. The stress p53 via IR drive cell cycle molecular species MPF and cyclin dynamics to different states, namely, oscillation death, oscillations of periods, chaotic and sustain oscillation in their bifurcation diagram. We predict that there could be a critical Δtc induced by p53 via IRc, where, if Δt〈Δtc the cell cycle may come back to normal state, otherwise it will go to cell cycle arrest (apoptosis).
authors.affiliation: School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India; College of Applied Medical Sciences, University of Hail, Hail-2440, Kingdom of Saudi Arabia.
authors.forename: Md Jahoor
authors.initials: MJ
authors.lastname: Alam
authors.affiliation: Department of Computer Science, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Dharamshala-176215, India.
authors.forename: Vikram
authors.initials: V
authors.lastname: Singh
authors.affiliation: School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India.
authors.forename: R K Brojen
authors.initials: RK
authors.lastname: Singh
mesh_terms: D002453:Cell Cycle / Q000502:physiology* / Q000528:radiation effects; D016213:Cyclins / Q000378:metabolism; D016200:Maturation-Promoting Factor / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism; D011839:Radiation, Ionizing; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016213:Cyclins; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2; D016200:Maturation-Promoting Factor