title: A Philosophical Perspective on Evolutionary Systems Biology.
abstract: Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.
authors.affiliation: Department of Philosophy, University of Sydney, Sydney, Australia.
authors.forename: Maureen A
authors.initials: MA
authors.lastname: O'Malley
authors.affiliation: School of Life Sciences, University of Warwick, Coventry, UK.
authors.forename: Orkun S
authors.initials: OS
authors.lastname: Soyer
authors.affiliation: Department of Biology, Center for Genomics and Systems, Biology, New York University, New York, NY, USA.
authors.forename: Mark L
authors.initials: ML
authors.lastname: Siegal
keywords: Evolutionary biology; Evolutionary systems biology; Explanation; Philosophy of biology; Philosophy of science; Systems biology