title: Guest Editorial: An Update on Stroke Intervention.
abstract: Endovascular treatment for acute ischemic stroke has changed remarkably over the past decade. Beginning with IA thrombolytic administration, endovascular strategies have evolved to include aspiration, self-expanding intracranial stents, and now retrievable stents. With the recent publication of 5 randomized, controlled studies (MR CLEAN, EXTEND-IA, ESCAPE, SWIFT PRIME, and REVASCAT), mechanical thrombectomy, when used in combination with IV tPA, has demonstrated a significant radiographic and clinical benefit over traditional strategies with IV tPA alone. These results have placed endovascular therapy at the forefront of stroke treatment, redefining the standard of care.
authors.affiliation: *Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; ‡Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, New York; §Departments of Neurology and Neurosurgery, University of South Florida College of Medicine, Tampa, Florida; ¶Department of Radiology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; ‖Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York; #Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York; **Jacobs Institute, Buffalo, New York.
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Munich
authors.forename: Maxim
authors.initials: M
authors.lastname: Mokin
authors.forename: Kenneth V
authors.initials: KV
authors.lastname: Snyder
authors.forename: Adnan H
authors.initials: AH
authors.lastname: Siddiqui
authors.forename: L Nelson
authors.initials: LN
authors.lastname: Hopkins
authors.forename: Elad I
authors.initials: EI
authors.lastname: Levy
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D057510:Endovascular Procedures / Q000379:methods; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015607:Stents; D020521:Stroke / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D017131:Thrombectomy / Q000379:methods; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator