title: P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C-N, C-O, and C-C Cross-Coupling Reactions.
abstract: The non-nucleophilic organic superbase P2Et phosphazene can enable a broad range of palladium-catalyzed cross-coupling reactions, including C-C, C-N, and C-O couplings of aryl chlorides, bromides, and iodides at room temperature. The mildness and substrate compatibility of this chemistry can deliver immediate synthetic utility for the preparation of complex molecules.
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, New Jersey 07065, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Buitrago Santanilla
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, New Jersey 07065, United States.
authors.forename: Melodie
authors.initials: M
authors.lastname: Christensen
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, New Jersey 07065, United States.
authors.forename: Louis-Charles
authors.initials: LC
authors.lastname: Campeau
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, New Jersey 07065, United States.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Davies
authors.affiliation: Department of Process Chemistry, Merck Research Laboratories, Merck and Co. Inc., Rahway, New Jersey 07065, United States.
authors.forename: Spencer D
authors.initials: SD
authors.lastname: Dreher