title: Vasopressin signaling at brain level controls stress hormone release: the vasopressin-deficient Brattleboro rat as a model.
abstract: The nonapeptide arginine vasopressin (AVP) has long been suggested to play an important role as a secretagogue for triggering the activity of the endocrine stress response. Most recent studies employed mutant mice for analyzing the importance of AVP for endocrine regulation under stress. However, it is difficult to compare and draw overall conclusions from all these studies as mixing the genetic material from different mouse strains has consequences on the individual's stress response. Moreover, mice are not ideal subjects for several experimental procedures. Therefore, to get more insight, we used a rather old mutant rat model: the AVP-deficient Brattleboro rat. The present short review is aimed at providing the most interesting results of these studies within the last 8 years that allowed gaining new insights in the potential signal function of AVP in stress and endocrine regulation.
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Dóra
authors.initials: D
authors.lastname: Zelena
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Ottó
authors.initials: O
authors.lastname: Pintér
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. balazsfi.diana@koki.mta.hu.|János Szentágothai School of Neurosciences, Semmelweis University, Budapest, Hungary. balazsfi.diana@koki.mta.hu.
authors.forename: Diána Gabriella
authors.initials: DG
authors.lastname: Balázsfi
authors.affiliation: AG Neuroendokrinologie & Verhalten, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität, Leipziger Str. 44/Haus 1, 39120, Magdeburg, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Langnaese
authors.affiliation: AG Neuroendokrinologie & Verhalten, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität, Leipziger Str. 44/Haus 1, 39120, Magdeburg, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Richter
authors.affiliation: Max-Planck-Institut für Psychiatrie, Munich, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Landgraf
authors.affiliation: Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Gábor B
authors.initials: GB
authors.lastname: Makara
authors.affiliation: AG Neuroendokrinologie & Verhalten, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität, Leipziger Str. 44/Haus 1, 39120, Magdeburg, Germany. mario.engelmann@med.ovgu.de.|Center for Behavioral Brain Sciences, Magdeburg, Germany. mario.engelmann@med.ovgu.de.
authors.forename: Mario
authors.initials: M
authors.lastname: Engelmann
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004703:Endocrine System / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D051381:Rats; D011910:Rats, Brattleboro; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D001127:Arginine Vasopressin
keywords: AVP; Brattleboro rat; HPA axis; Hormone; Stress; Vasopressin