title: Signaling pathway factors expression in renal tissue of apoE-knockout mice.
abstract: Apolipoprotein E (apoE) is regarded as one of the major plasma lipoproteins, and it plays an important role in the transport and metabolism of lipids. apoE can be found in multiple tissues, such as liver, kidney, jejunum, urinary bladder, ileum, colon, brain, adrenal glands, lung, ovary, spleen, pancreas, and testis, etc. As a secreted protein, it plays an important role in the systemic lipoprotein metabolism and vascular wall homeostasis and in the pathogenesis of renal diseases. apoE-knockout (apoE(-/-)) mice is a classic model of atherosclerosis and renal diseases. However, no review summed up the signaling pathway factors expression in renal tissue of apoE-knockout mice. The literatures were searched extensively and this review was performed to review the signaling pathway factors expression in renal tissue of apoE-knockout mice.
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D001057:Apolipoproteins E; D016207:Cytokines; D035683:MicroRNAs
keywords: Apolipoprotein E (apoE); renal diseases; signaling pathway factors