title: Hepatitis: After HCV cure, HBV cure?
abstract: Current treatments efficiently control chronic HBV infection but they do not lead to its elimination. Now, Ebert and colleagues have shown that cellular inhibitor of apoptosis proteins (cIAPs) prevent TNF-mediated killing of infected hepatocytes and that cIAP antagonists might lead to HBV cure by promoting death of infected cells.
authors.affiliation: INSERM U1052, CNRS UMR_5286, Cancer Research Center of Lyon (CRCL), 151 Cours Albert Thomas, 69424 Lyon Cedex 03, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Lucifora
authors.affiliation: INSERM U1052, CNRS UMR_5286, Cancer Research Center of Lyon (CRCL), 151 Cours Albert Thomas, 69424 Lyon Cedex 03, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Trepo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006509:Hepatitis B / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000037:antagonists & inhibitors*; D008099:Liver / Q000473:pathology*; D051379:Mice; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D051034:Inhibitor of Apoptosis Proteins; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha