title: Tyrosine kinase inhibitor-associated syndrome of inappropriate secretion of anti-diuretic hormone.
abstract: Hyponatremia is a common complication among cancer patients. Certain antineoplastic agents have been associated with syndrome of inappropriate secretion of anti-diuretic hormone-induced hyponatremia. The most common agents associated with secretion of anti-diuretic hormone are vinca alkaloids, platinum compounds, and alkylating agents. We report a case of secretion of anti-diuretic hormone associated with tyrosine kinase inhibitors.
authors.affiliation: Department of Clinical Pharmacy, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
authors.forename: Jordan
authors.initials: J
authors.lastname: Hill
authors.affiliation: Department of Clinical Pharmacy, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA Jenna.Shields@va.gov.
authors.forename: Jenna
authors.initials: J
authors.lastname: Shields
authors.affiliation: Department of Clinical Pharmacy, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
authors.forename: Vida
authors.initials: V
authors.lastname: Passero
mesh_terms: D000369:Aged, 80 and over; D000814:Aniline Compounds / Q000009:adverse effects / Q000627:therapeutic use; D000069439:Dasatinib / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D009570:Nitriles / Q000009:adverse effects / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000814:Aniline Compounds; D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011804:Quinolines; C471992:bosutinib; C498826:nilotinib; D000069439:Dasatinib
keywords: Dasatinib; hyponatremia; syndrome of inappropriate secretion of anti-diuretic hormone; tyrosine kinase inhibitor