title: Loss of the liver X receptor LXRα/β in peripheral sensory neurons modifies energy expenditure.
abstract: Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose ganglia of the vagus nerve. In this study, we show mice lacking LXRα/β in peripheral sensory neurons have increased energy expenditure and weight loss when fed a Western diet (WD). Our findings suggest that the ability to metabolize and sense cholesterol and/or fatty acids in peripheral neurons is an important requirement for physiological adaptations to WDs.
authors.affiliation: Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Virginie
authors.initials: V
authors.lastname: Mansuy-Aubert
authors.affiliation: Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Laurent
authors.initials: L
authors.lastname: Gautron
authors.affiliation: Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Syann
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Angie L
authors.initials: AL
authors.lastname: Bookout
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Christine
authors.initials: C
authors.lastname: Kusminski
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Philipp E
authors.initials: PE
authors.lastname: Scherer
authors.affiliation: Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: David J
authors.identifier: http://orcid.org/0000-0002-4355-0796
authors.initials: DJ
authors.lastname: Mangelsdorf
authors.affiliation: Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, United States.
authors.forename: Joel K
authors.initials: JK
authors.lastname: Elmquist
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D002153:Calorimetry, Indirect; D066273:Diet, Western; D004734:Energy Metabolism / Q000502:physiology*; D000071518:Liver X Receptors; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009620:Nodose Ganglion / Q000502:physiology*; D057093:Orphan Nuclear Receptors / Q000172:deficiency*; D011984:Sensory Receptor Cells / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology
chemical_list: D000071518:Liver X Receptors; C000605214:Nr1h3 protein, mouse; D057093:Orphan Nuclear Receptors
keywords: energy expenditure; mouse; neuroscience; nuclear receptors; sensory neurons