title: Serum adipocytokines and adipose weight gain: a pilot study in adolescent females initiating depot medroxyprogesterone acetate.
abstract: OBJECTIVE
  To evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA).
  
  
  METHODS
  Percent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified.
  
  
  RESULTS
  Mean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months.
  
  
  CONCLUSIONS
  Serum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains.
authors.affiliation: Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: andrea.bonny@nationwidechildrens.org.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Bonny
authors.affiliation: Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
authors.forename: Hannah L H
authors.initials: HL
authors.lastname: Lange
authors.affiliation: The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Erinn M
authors.initials: EM
authors.lastname: Hade
authors.affiliation: Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA; MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
authors.forename: Bram
authors.initials: B
authors.lastname: Kaufman
authors.affiliation: Akron Children's Hospital, One Perkins Square, Akron, OH 44308-1062, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Reed
authors.affiliation: Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA.
authors.forename: Sam
authors.initials: S
authors.lastname: Mesiano
mesh_terms: D054392:Adipokines / Q000097:blood*; D050154:Adiposity / Q000187:drug effects*; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D010865:Pilot Projects; D011446:Prospective Studies; D015430:Weight Gain / Q000187:drug effects*; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; D003271:Contraceptive Agents, Female; D003692:Delayed-Action Preparations; D017258:Medroxyprogesterone Acetate
keywords: Adipocytokines; Adipose tissue; Adolescents; Depot medroxyprogesterone acetate; Weight gain