title: Surface plasmon resonance: a label-free tool for cellular analysis.
abstract: Surface plasmon resonance (SPR) is a popular technique that allows for sensitive, specific, label-free and real-time assessment of biomolecular interactions. SPR is a nondestructive, modular and flexible tool for various applications in biomedical sciences ranging from cell sorting, cell surface characterization and drug discovery. In this review, we will discuss more specifically how SPR is used to monitor the dynamics of various types of cellular binding events and morphological adherence changes in response to external stimuli.
authors.affiliation: University of North Carolina at Greensboro, Department of Nanoscience, 2907 E Lee Street, Greensboro, NC, 27401, USA.
authors.forename: Effat
authors.initials: E
authors.lastname: Zeidan
authors.affiliation: University of North Carolina at Greensboro, Department of Nanoscience, 2907 E Lee Street, Greensboro, NC, 27401, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Kepley
authors.affiliation: University of North Carolina at Greensboro, Department of Nanoscience, 2907 E Lee Street, Greensboro, NC, 27401, USA.
authors.forename: Christie
authors.initials: C
authors.lastname: Sayes
authors.affiliation: University of North Carolina at Greensboro, Department of Nanoscience, 2907 E Lee Street, Greensboro, NC, 27401, USA.
authors.forename: Marinella G
authors.initials: MG
authors.lastname: Sandros
mesh_terms: D000818:Animals; D018441:Biofilms / Q000254:growth & development; D055592:Biophysical Phenomena; D058948:Cell Tracking; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000254:growth & development; D057809:HEK293 Cells; D006801:Humans; D057054:Molecular Imaging; D020349:Surface Plasmon Resonance
keywords: bacterial adherence properties; biomolecular interactions; cell sorting; cellular detection; cellular morphology alterations; cellular secretions; long-range surface plasmon resonance; nanoscale cellular dynamics; optical biosensor; single-cell analysis