title: Treatment of Recurrent Hepatitis C Genotype-4 Post-Liver Transplantation with Sofosbuvir plus Simeprevir.
abstract: Hepatitis C virus (HCV) infection remains a leading indication for orthotopic liver transplantation (OLT) worldwide. Recurrence of HCV following OLT is universal. There is scarcity of data on the post-OLT treatment of HCV genotype-4-the predominant genotype in North Africa and the Middle East. Herein, we present three patients who have experienced HCV genotype-4 recurrence post-OLT. All three patients were interferon-naive and were treated with simeprivir (SIM) and sofosbuvir (SOF) combination therapy for 12-24 weeks. The data from this case series show that SIM+SOF are well-tolerated and effective for achieving viral clearance in HCV genotype-4 post-OLT patients. Given the limited nature of a case series, further research must be pursued regarding post-OLT HCV genotype-4 responses to direct-acting anti-viral therapy.
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ascha
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: Mona
authors.initials: M
authors.lastname: Ascha
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: N N
authors.initials: NN
authors.lastname: Zein
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: N
authors.initials: N
authors.lastname: Alkhouri
authors.affiliation: Department of General Surgery, Transplant Center, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: B
authors.initials: B
authors.lastname: Eghtesad
authors.affiliation: Department of General Surgery, Transplant Center, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: K
authors.initials: K
authors.lastname: Abu-Elmagd
authors.affiliation: Department of General Surgery, Transplant Center, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: T
authors.initials: T
authors.lastname: Diago
authors.affiliation: Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.
authors.forename: I A
authors.initials: IA
authors.lastname: Hanouneh
keywords: Genotype; Hepacivirus; Interferon; Liver transplantation