title: Thromboelastometric evaluation of hemostasis in dogs infected with Leishmania infantum.
abstract: OBJECTIVE
  Evaluation of hemostasis using thromboelastometry in dogs with leishmaniasis before and after treatment.
  
  
  METHODS
  Longitudinal observational study.
  
  
  METHODS
  University veterinary teaching hospital.
  
  
  METHODS
  Eighty-four adult, client-owned dogs.
  
  
  RESULTS
  Whole blood samples for the coagulation profile were collected from symptomatic dogs with leishmaniasis (group S), asymptomatic dogs with leishmaniasis after treatment (group T), and a control group of healthy dogs (group H). Hemostasis was evaluated by means of standard coagulation profile (prothrombin time, activated partial thromboplastin time, and fibrinogen) and by thromboelastometry (ROTEM). Prothrombin time and activated partial thromboplastin time were within the upper reference range in all 3 groups. Comparison of the ROTEM variables between the 3 groups showed statistically significant differences between group S versus groups T and H, but remaining within the reference ranges. Statistically significant differences in hematocrit and fibrinogen concentrations were noted between groups (group S vs. H: hematocrit P = 0.001, fibrinogen P = 0.002; Group S vs. T: hematocrit P = 0.001, fibrinogen P = 0.001). These variations have interfered with some parameters of the ROTEM profile.
  
  
  CONCLUSIONS
  This study showed normal standard coagulation profiles in all 3 groups evaluated. The ROTEM results did not fall outside of the maximum values of the reference ranges.
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bruno
authors.affiliation: the Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta (Maurella), via Bologna 148, 10154, Torino, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Maurella
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Falco
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Tarducci
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Zanatta
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Angelo
authors.affiliation: Department of Veterinary Science, Clinical Medicine Section, via Leonardo da Vinci 44, 10095, Grugliasco (TO), Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Borrelli
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary; D004283:Dog Diseases / Q000097:blood* / Q000469:parasitology; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D018314:Leishmania infantum / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011517:Prothrombin Time / Q000662:veterinary; D012016:Reference Values; D013916:Thrombelastography / Q000662:veterinary
chemical_list: D005340:Fibrinogen
keywords: canine; coagulation; leishmaniasis; thromboelastometry