title: PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c.
abstract: As one of the common malignant tumors that threaten human health severely, gastric carcinoma is the second highest cause of cancer death and the fourth most common cancer globally. However, the mechanism underlying gastric cancer is still not fully understood. PABPC1 plays an important role in translation, control the rate of mRNA deadenylation and participates in mRNA decay, which is involved in carcinogenesis. Here in present study, we reported that PABPC1 is an oncogenic protein in gastric carcinoma. The results showed that PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis by upregulating pro-apoptotic proteins and downregulating anti-apoptotic proteins. In addition, miR-34c is a target of PABPC1, and miR-34c is critically essential for the function of PABPC1. In summary, PABPC1 exerts carcinogenesis and promotes growth and survival of gastric cancer cells by regulating miR-34c.
authors.affiliation: Department of General Surgery, Huadong Hospital Shanghai 200040.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Huadong Hospital Shanghai 200040.
authors.forename: Hao
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of General Surgery, Huadong Hospital Shanghai 200040.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Huadong Hospital Shanghai 200040.
authors.forename: Qi
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000368:Aged; D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D039122:Poly(A)-Binding Protein I / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs; D039122:Poly(A)-Binding Protein I
keywords: PABPC1; carcinogenesis; gastric carcinoma; miR-34c