title: Paramagnetic relaxation based biosensor for selective dopamine detection.
abstract: We report a new NMR relaxation time-based method for sensitive and selective dopamine detection using paramagnetic nanoparticles. The Fe(3+) species in the nanoparticles serves as both the contrast agent and the target recognition element. The results demonstrate that paramagnetic nanoparticles, similar to the more widely used superparamagnetic nanoparticles, can be integrated into relaxation based detection schemes while avoiding the aggregation problem commonly associated with superparamagnetic nanoparticles.
authors.affiliation: Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA. peng.zhang@uc.edu.
authors.forename: Tevhide Ozkaya
authors.initials: TO
authors.lastname: Ahmadov
authors.forename: Padmanabh
authors.initials: P
authors.lastname: Joshi
authors.forename: Jinnan
authors.initials: J
authors.lastname: Zhang
authors.forename: Keaton
authors.initials: K
authors.lastname: Nahan
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Caruso
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
mesh_terms: D015374:Biosensing Techniques; D002412:Cations / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis* / Q000134:cerebrospinal fluid*; D004492:Edetic Acid / Q000737:chemistry; D006801:Humans; D007501:Iron / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D002412:Cations; D003287:Contrast Media; D012821:Silanes; D012822:Silicon Dioxide; D004492:Edetic Acid; D007501:Iron; D004298:Dopamine