title: A clinical study to measure anti-erosion properties of a stabilized stannous fluoride dentifrice relative to a sodium fluoride/triclosan dentifrice.
abstract: OBJECTIVE
  To compare the enamel protection efficacy of a stabilized stannous fluoride (SnF2) dentifrice to a sodium fluoride (NaF)/triclosan dentifrice following acidic erosive challenge.
  
  
  METHODS
  In this in situ, randomized, controlled, double-blind, two-treatment, four-period crossover clinical trial, subjects wore an appliance fitted with human enamel samples 6 h day-1during each 15-day treatment period. Twice each treatment day they swished with their assigned dentifrice slurry: 0.454% SnF2/0.077% NaF or 0.32% NaF/0.3% triclosan. After each treatment and two other times daily, subjects swished with 250 ml of orange juice over a 10-min period (acidic erosive challenge). Enamel samples were measured for tooth surface loss using contact profilometry at baseline and days 10 and 15.
  
  
  RESULTS
  Thirty-six subjects (mean age 44.8 years, range 23-65 years) were randomized to treatment; 33 subjects completed the final study visit. There were no statistically significant baseline differences (P > 0.44) in the specimen surfaces of the two dentifrice treatment groups via profilometry. At day 10, the SnF2dentifrice provided a statistically significant (P < 0.0001) reduction in enamel loss by 67% versus the NaF/triclosan dentifrice with estimated medians of 1.22 and 3.68 μm, respectively. At day 15, the SnF2dentifrice again provided a significantly greater benefit (P < 0.0001) against tooth surface loss versus the NaF/triclosan dentifrice, with 68% less erosion, and estimated medians of 1.60 and 5.03 μm, respectively. Both dentifrices were well tolerated.
  
  
  CONCLUSIONS
  A stabilized SnF2dentifrice provided superior protection against the initiation and progression of tooth enamel surface loss in situ after erosive challenge compared to a NaF/triclosan dentifrice.
authors.affiliation: University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: N X
authors.initials: NX
authors.lastname: West
authors.affiliation: University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: J
authors.initials: J
authors.lastname: Seong
authors.affiliation: University of Bristol Dental School and Hospital, Bristol, UK.
authors.forename: N
authors.initials: N
authors.lastname: Hellin
authors.affiliation: Procter & Gamble Company, Mason, OH, USA.
authors.forename: H
authors.initials: H
authors.lastname: Eynon
authors.affiliation: Procter & Gamble Company, Mason, OH, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Barker
authors.affiliation: Procter & Gamble Company, Mason, OH, USA.
authors.forename: T
authors.initials: T
authors.lastname: He
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D003802:Dentifrices; D004311:Double-Blind Method; D005260:Female; D005460:Fluorides, Topical / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014077:Tooth Erosion / Q000517:prevention & control*; D014260:Triclosan / Q000627:therapeutic use*
chemical_list: D003802:Dentifrices; D005460:Fluorides, Topical; D014002:Tin Fluorides; C023807:sodium fluoride topical preparation; D014260:Triclosan; D012969:Sodium Fluoride
keywords: dentifrice; erosion; sodium fluoride; stannous fluoride; triclosan