title: Unsaturated fatty acids supplementation reduces blood lead level in rats.
abstract: Some dietary factors could inhibit lead toxicity. The aim of this study was to evaluate the effect of dietary compounds rich in unsaturated fatty acids (FA) on blood lead level, lipid metabolism, and vascular reactivity in rats. Serum metallothionein and organs' lead level were evaluated with the aim of assessing the possible mechanism of unsaturated FA impact on blood lead level. For three months, male Wistar rats that were receiving drinking water with (100 ppm Pb) or without lead acetate were supplemented per os daily with virgin olive oil or linseed oil (0.2 mL/kg b.w.) or egg derived lecithin fraction: "super lecithin" (50 g/kg b.w.). Mesenteric artery was stimulated ex vivo by norepinephrine (NE) administered at six different doses. Lecithin supplementation slightly reduced pressor responses of artery to NE. Lead administered to rats attenuated the beneficial effect of unsaturated FA on lipid metabolism and vascular reactivity to adrenergic stimulation. On the other hand, the super lecithin and linseed oil that were characterized by low omega-6 to omega-3 ratio (about 1) reduced the blood lead concentration. This effect was observed in lead poisoned rats (p < 0.0001) and also in rats nonpoisoned with lead (p < 0.05).
authors.affiliation: Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Skoczyńska
authors.affiliation: Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Wojakowska
authors.affiliation: Department of Human Nutrition, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
authors.forename: Dorian
authors.initials: D
authors.lastname: Nowacki
authors.affiliation: Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Bobak
authors.affiliation: Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Turczyn
authors.affiliation: Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Smyk
authors.affiliation: Department of Internal and Occupational Diseases, Wroclaw Medical University, 50-556 Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szuba
authors.affiliation: Department of Animal Products Technology and Quality Management, Wroclaw University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Trziszka
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D043371:Fatty Acids, Omega-6 / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D066298:In Vitro Techniques; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D054709:Lecithins / Q000008:administration & dosage; D008043:Linseed Oil / Q000008:administration & dosage; D008055:Lipids / Q000097:blood; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000503:physiopathology; D008668:Metallothionein / Q000097:blood; D009638:Norepinephrine / Q000494:pharmacology; D000069463:Olive Oil / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D002352:Carrier Proteins; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D054709:Lecithins; D008055:Lipids; D000069463:Olive Oil; D014662:Vasoconstrictor Agents; C030363:lipid transfer protein; D007854:Lead; D008043:Linseed Oil; D008668:Metallothionein; D009638:Norepinephrine