title: [Guidelines for the use of second-generation long-acting antipsychotics].
abstract: Long-acting injectable antipsychotics constitute a valuable alternative for the treatment of psychotic disorders, mainly schizophrenia. They assure a more stable drug level, improve treatment compliance, and increase the chances for favorable and long-lasting improvement. Additionally, the long-acting second-generation antipsychotics combine the values of long-acting injectable drugs with the values of atypical antipsychotics. Four second generation long-acting antipsychotics have been described: risperidone, olanzapine, aripiprazole and paliperidone. The indications for their use, treatment strategy, tolerance, and potential interactions are discussed.
authors.affiliation: III Klinika Psychiatryczna Instytutu Psychiatrii i Neurologii w Warszawie.
authors.forename: Marek
authors.initials: M
authors.lastname: Jarema
authors.affiliation: III Klinika Psychiatryczna Instytutu Psychiatrii i Neurologii.
authors.forename: Adam
authors.initials: A
authors.lastname: Wichniak
authors.affiliation: Zakład Zaburzeń Afektywnych Katedry Psychiatrii, UJ Collegium Medicum.
authors.forename: Dominika
authors.initials: D
authors.lastname: Dudek
authors.affiliation: Klinika Psychiatrii Pomorskiego Uniwersytetu Medycznego w Szczecinie.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
authors.affiliation: Zakład Farmakologii Instytutu Psychiatrii i Neurologii w Warszawie.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bieńkowski
authors.affiliation: Klinika Psychiatrii Dorosłych Uniwersytetu Medycznego im. K. Marcinkowskiego w Poznaniu.
authors.forename: Janusz
authors.initials: J
authors.lastname: Rybakowski
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage*; D000068180:Aripiprazole; D001569:Benzodiazepines / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D006801:Humans; D007267:Injections; D007555:Isoxazoles / Q000008:administration & dosage; D000077152:Olanzapine; D000068882:Paliperidone Palmitate; D010879:Piperazines / Q000008:administration & dosage; D017410:Practice Guidelines as Topic; D011743:Pyrimidines / Q000008:administration & dosage; D015363:Quinolones / Q000008:administration & dosage; D018967:Risperidone / Q000008:administration & dosage; D012559:Schizophrenia / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D007555:Isoxazoles; D010879:Piperazines; D011743:Pyrimidines; D015363:Quinolones; D001569:Benzodiazepines; D000068180:Aripiprazole; D018967:Risperidone; D000077152:Olanzapine; D000068882:Paliperidone Palmitate
keywords: guidelines for use; long-acting antipsychotics; schizophrenia