title: Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions.
abstract: This study tested the impact of moxidectin at peripartum on nematode fecal egg count (FEC) and clinical parameters on ewes in the high altitude tropical Andes of Colombia. FEC and clinical evaluations were performed on 9 occasions in 43 naturally infected ewes before and during gestation and after lambing. Moxidectin (Mox, 200 µg kg(-1)) was applied at late pregnancy (T 1, n = 15) or 48 hours after parturition (T 2, n = 14). 14 untreated ewes served as controls (C). Suckling lambs (n = 58) remained untreated and underwent four clinical and parasitological evaluations until 8 weeks after birth. Mox efficacy equaled 99.3% (T 1) and 96.9% (T 2). Highest mean FEC value reflecting periparturient nematode egg rise (PPER) was recorded in C ewes at 4-6 weeks after lambing. Significant FEC reductions were found in T 1 (94.8%) and T 2 (96.7%) ewes (p < 0.05). All lambs showed a significant and ewes-group independent increase in FEC before weaning (p < 0.05). Clinical parameters (anemia and diarrhea) showed time- and treatment-related differences (p < 0.05). Monitoring of FEC and clinical parameters linked to gastrointestinal parasite infections allowed demonstrating that postpartum or preweaning are two critical periods to nematode infection for sheep raised under tropical Andes high altitude conditions. Use of Mox as anthelmintic treatment prevented PPER.
authors.affiliation: Genetic Institute, National University of Colombia, Carrera 30 No. 45-03, Edificio 426, Bogotá D.C., Colombia ; Unit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium.
authors.forename: J J
authors.initials: JJ
authors.lastname: Vargas-Duarte
authors.affiliation: Unit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium ; Faculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., Colombia.
authors.forename: H
authors.initials: H
authors.lastname: Lozano-Márquez
authors.affiliation: Faculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., Colombia.
authors.forename: H A
authors.initials: HA
authors.lastname: Grajales-Lombana
authors.affiliation: Faculty of Veterinary Medicine and Animal Science, National University of Colombia, Carrera 30 No. 45-03, Edificio 481, Bogotá D.C., Colombia.
authors.forename: C
authors.initials: C
authors.lastname: Manrique-Perdomo
authors.affiliation: Faculty of Veterinary Medicine, Cooperative University of Colombia, Calle 30 No. 33-51, Bucaramanga, Colombia.
authors.forename: D A
authors.initials: DA
authors.lastname: Martínez-Bello
authors.affiliation: Research Unit of Epidemiology and Risk Analysis Applied to Veterinary Sciences (UREAR), Fundamental and Applied Research for Animal and Health (FARAH), University of Liège, boulevard de Colonster 20, 4000 Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Saegerman
authors.affiliation: Unit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Raes
authors.affiliation: Unit of Integrated Veterinary Research, Department of Veterinary Medicine, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Kirschvink