title: Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: S
authors.initials: S
authors.lastname: He
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: B
authors.initials: B
authors.lastname: Malik
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: D
authors.initials: D
authors.lastname: Borkin
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: H
authors.initials: H
authors.lastname: Miao
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kempinska
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: T
authors.initials: T
authors.lastname: Purohit
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
authors.forename: B
authors.initials: B
authors.lastname: Parkin
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
authors.forename: S N
authors.initials: SN
authors.lastname: Malek
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Danet-Desnoyers
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Muntean
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: T
authors.initials: T
authors.lastname: Cierpicki
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor MI, USA.
authors.forename: J
authors.initials: J
authors.lastname: Grembecka
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D011495:Histone-Lysine N-Methyltransferase / Q000037:antagonists & inhibitors*; D006801:Humans; D015456:Leukemia, Biphenotypic, Acute / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D051788:Myeloid-Lymphoid Leukemia Protein / Q000037:antagonists & inhibitors* / Q000502:physiology*; D015514:Oncogene Proteins, Fusion / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*
chemical_list: C497422:KMT2A protein, human; C105373:MEN1 protein, human; C113855:MLL-AF4 fusion protein, human; C474558:MLL-AF9 fusion protein, human; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase