title: Metal-Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands.
abstract: Control over particle size and composition are pivotal to tune the properties of metal organic frameworks (MOFs), for example, for biomedical applications. Particle-size control and functionalization of MIL-88A were achieved by using stoichiometric replacement of a small fraction of the divalent fumarate by monovalent capping ligands. A fluorine-capping ligand was used to quantify the surface coverage of capping ligand at the surface of MIL-88A. Size control at the nanoscale was achieved by using a monovalent carboxylic acid-functionalized poly(ethylene glycol) (PEG-COOH) ligand at different concentrations. Finally, a biotin-carboxylic acid capping ligand was used to functionalize MIL-88A to bind fluorescently labeled streptavidin as an example towards bioapplications.
authors.affiliation: Molecular NanoFabrication group, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (The Netherlands), Fax: (+31) 53489-4645 http://www.utwente.nl/tnw/mnf/
authors.forename: Timon
authors.initials: T
authors.lastname: Rijnaarts
authors.affiliation: Molecular NanoFabrication group, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (The Netherlands), Fax: (+31) 53489-4645 http://www.utwente.nl/tnw/mnf/
authors.forename: Raquel
authors.initials: R
authors.lastname: Mejia-Ariza
authors.affiliation: Molecular NanoFabrication group, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (The Netherlands), Fax: (+31) 53489-4645 http://www.utwente.nl/tnw/mnf/
authors.forename: Richard J M
authors.initials: RJ
authors.lastname: Egberink
authors.affiliation: Molecular NanoFabrication group, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (The Netherlands), Fax: (+31) 53489-4645 http://www.utwente.nl/tnw/mnf/
authors.forename: Wies
authors.initials: W
authors.lastname: van Roosmalen
authors.affiliation: Molecular NanoFabrication group, MESA Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (The Netherlands), Fax: (+31) 53489-4645 http://www.utwente.nl/tnw/mnf/. J.Huskens@utwente.nl.
authors.forename: Jurriaan
authors.initials: J
authors.lastname: Huskens
keywords: capping ligands; metal-organic frameworks; multivalent materials; nanoparticles; supramolecular chemistry