title: Is There Any Role for Serum Cathepsin S and CRP Levels on Prognostic Information in Breast Cancer? The Swedish Mammography Cohort.
abstract: Breast cancer is the most common cancer among women, and both low-grade inflammation and cathepsins might have important roles in breast cancer. We questioned whether prediagnostic circulating levels of C-reactive protein (CRP), cathepsin B, and cathepsin S were associated with breast cancer risk. Sixty-nine incident breast cancer cases diagnosed after blood collection and 719 controls from the Swedish Mammography Cohort were analyzed for systemic CRP, cathepsin B, and cathepsin S. Cathepsin S and inflammation (high-sensitivity CRP [hsCRP])-adjusted cathepsin S were inversely associated with breast cancer risk (cathepsin S: odds ratio [OR] for top vs. bottom tertile=0.46; 95% confidence interval [CI]=0.23-0.92; p(trend)=0.02; hsCRP-adjusted cathepsin S: OR of 0.44; 95% CI=0.22-0.87; p(trend)=0.02). hsCRP was significantly associated with increased breast cancer risk (OR for top vs. bottom tertile=2.01; 95% CI=1.02-3.95; p(trend)=0.04). No significant association was observed between cathepsin B and breast cancer risk (OR for top vs. bottom tertile=0.67; 95% CI=0.32-1.40; ptrend=0.30). These observations lead to the hypothesis that levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
authors.affiliation: 1 Chaire d'Excellence Program, Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculté de Pharmacie, Université d'Auvergne , Clermont-Ferrand, France .|2 Oxidative Stress and Inflammation, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University , Uppsala, Sweden .
authors.forename: Samar
authors.initials: S
authors.lastname: Basu
authors.affiliation: 3 Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute , Stockholm, Sweden .|4 Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital , Boston, Massachusetts.
authors.forename: Holly
authors.initials: H
authors.lastname: Harris
authors.affiliation: 5 Clinical Chemistry, Department of Medical Science, Faculty of Medicine, Uppsala University , Uppsala, Sweden .
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.affiliation: 1 Chaire d'Excellence Program, Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculté de Pharmacie, Université d'Auvergne , Clermont-Ferrand, France .
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
authors.affiliation: 3 Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute , Stockholm, Sweden .
authors.forename: Alicja
authors.initials: A
authors.lastname: Wolk
mesh_terms: D000368:Aged; D015415:Biomarkers; D001943:Breast Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000401:mortality*; D002097:C-Reactive Protein; D016022:Case-Control Studies; D002403:Cathepsins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D002403:Cathepsins; C028217:cathepsin S