title: [Study on biomarker of Tripterygium wilfordii in treatment of rheumatoid arthritis based on PK/PD].
abstract: To observe the serum samples and the anti-inflammatory effect of Tripterygium wilfordii in treating RA by using the pharmacokinetic-pharmacodynamic model, make a correlation analysis on concentration-time and effect-time curves, and explore RORγt, IL-17, STAT3, IL-6 mRNA transcriptional levels in rats by PCR. Methotrexate, tripterine and high-dose T. wilfordii could down-regulate RORγt, IL-17, STAT3, IL-6 mRNA transcriptional levels in AA rat lymph nodes. The study on PK-PD model showed correlations between inflammatory factors and blood concentration of T. wilfordii. T. wilfordii and its main active constituent tripterine could show the inflammatory effect and treat RA by inhibiting IL-17 cytokine.
authors.forename: Shi-jia
authors.initials: SJ
authors.lastname: Liu
authors.forename: Guo-liang
authors.initials: GL
authors.lastname: Dai
authors.forename: Bing-ting
authors.initials: BT
authors.lastname: Sun
authors.forename: Chang-yin
authors.initials: CY
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Wu
authors.lastname: Ma Shi-tang
authors.forename: Wen-zheng
authors.initials: WZ
authors.lastname: Ju
authors.forename: Heng-shan
authors.initials: HS
authors.lastname: Tan
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Fu
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D015415:Biomarkers; D005260:Female; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D053978:Pentacyclic Triterpenes; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D029757:Tripterygium; D014315:Triterpenes / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D020381:Interleukin-17; D015850:Interleukin-6; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C050414:celastrol