title: Glycine-Linked Nucleoside-β-Amino Acids: Polyamide Analogues of Nucleic Acids.
abstract: 3'-5'-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2'-deoxyribonucleoside-based β-amino acids interlinked by glycine to create uncharged polyamide DNA with 3'-5'-directionality. These oligomers as conjugates of α-amino acids and nucleoside-β-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA.
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India 411008.
authors.forename: Anjan
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India 411008.
authors.forename: Seema
authors.initials: S
authors.lastname: Bagmare
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India 411008.
authors.forename: Manojkumar
authors.initials: M
authors.lastname: Varada
authors.affiliation: Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune, India 411008.
authors.forename: Vaijayanti A
authors.initials: VA
authors.lastname: Kumar
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D009705:Nucleosides; D009757:Nylons; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA; D005998:Glycine