title: Anti-plasmodial activity of bradykinin and analogs.
abstract: To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.
authors.affiliation: Universidade Federal do ABC, Rua Santa Adélia 166, Santo André 09210-170, Brazil.
authors.forename: Adriana F
authors.initials: AF
authors.lastname: Silva
authors.affiliation: Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo 04044-020, Brazil.
authors.forename: Flávio L
authors.initials: FL
authors.lastname: Alves
authors.affiliation: Universidade Federal do ABC, Rua Santa Adélia 166, Santo André 09210-170, Brazil.
authors.forename: Cibele N
authors.initials: CN
authors.lastname: Pedron
authors.affiliation: Universidade Federal do ABC, Rua Santa Adélia 166, Santo André 09210-170, Brazil.
authors.forename: Marcelo D T
authors.initials: MD
authors.lastname: Torres
authors.affiliation: Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-902, Brazil.
authors.forename: Leandro S
authors.initials: LS
authors.lastname: Silva
authors.affiliation: Universidade Federal do Rio de Janeiro, Avenida Carlos Chagas Filho 373, Rio de Janeiro 21941-902, Brazil.
authors.forename: Ana A S
authors.initials: AA
authors.lastname: Pinheiro
authors.affiliation: Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo 04044-020, Brazil.
authors.forename: Antonio
authors.initials: A
authors.lastname: Miranda
authors.affiliation: Universidade Federal do ABC, Rua Santa Adélia 166, Santo André 09210-170, Brazil. Electronic address: vani.junior@ufabc.edu.br.
authors.forename: Vani X
authors.initials: VX
authors.lastname: Oliveira
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001920:Bradykinin / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D010964:Plasmodium gallinaceum / Q000187:drug effects*; D034101:Sporozoites / Q000187:drug effects
chemical_list: D000962:Antimalarials; D010455:Peptides; D001920:Bradykinin
keywords: Anti-plasmodial; Bradykinin; Malaria; Peptides; Plasmodium