title: Cell-based therapy for kidney disease.
abstract: The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. ; Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Chung
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.
authors.forename: In Kap
authors.initials: IK
authors.lastname: Ko
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Atala
authors.affiliation: Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Yoo
mesh_terms: D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D053686:Fetal Stem Cells / Q000637:transplantation; D006801:Humans; D007668:Kidney / Q000166:cytology; D007674:Kidney Diseases / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000637:transplantation; D033581:Stem Cell Transplantation / Q000379:methods
keywords: Acute kidney injury; Cell- and tissue-based therapy; Chronic kidney failure; Clinical trial; Evaluation studies