title: Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons.
abstract: Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia, lvfil@yandex.ru.
authors.forename: L V
authors.initials: LV
authors.lastname: Filippova
authors.forename: E Yu
authors.initials: EY
authors.lastname: Bystrova
authors.forename: F S
authors.initials: FS
authors.lastname: Malyshev
authors.forename: O N
authors.initials: ON
authors.lastname: Platonova
authors.forename: A D
authors.initials: AD
authors.lastname: Nozdrachev
mesh_terms: D000818:Animals; D003106:Colon / Q000294:innervation* / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D018613:Microscopy, Confocal; D009197:Myenteric Plexus / Q000378:metabolism*; D009619:Nociceptors / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013368:Submucous Plexus / Q000378:metabolism*; D050916:TRPV Cation Channels / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*
chemical_list: D051192:Receptors, Pattern Recognition; D050916:TRPV Cation Channels; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; C493922:Trpv1 protein, rat