title: Mitochondrial DNAs decreased and correlated with clinical features in HCV patients from Yunnan, China.
abstract: Hepatitis C was the most popular chronic infectious liver disease worldwide. It was identified that Hepatitis C virus (HCV) infection could lead to mitochondrial dysfunction, though the mechanism was not fully understood. To investigate whether mtDNA copy number could be affected by HCV infection and be associated with clinical features of HCV patients, mtDNA copy numbers were analyzed in 242 patients with HCV infection and 226 matched control samples. The results suggested that mtDNA copy numbers significantly decreased in HCV patients (68.80 ± 3.33) than in control samples (81.54 ± 4.50) (p = 0.022). When males/females were separated from total patients to compare mtDNA copy numbers with gender matched controls, mtDNA copy numbers still significantly decreased in male HCV patients (p = 0.002). Further analysis indicated that level of high-density lipoprotein cholesterol (HDL-C) was negatively correlated with mtDNA copy numbers in total HCV patients (r = -0.128, p = 0.047), and this correlation was more significant in male HCV patients (r = -0.266, p = 0.030). Intriguingly, aspartate amino-transferase (AST) showed positive correlation with mtDNA copy numbers (r = 0.260, p = 0.034) in male HCV patients. Our results indicated that mtDNA copy numbers depleted and correlated with clinical features in male HCV patients.
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: A-Mei
authors.initials: AM
authors.lastname: Zhang
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: Ke
authors.initials: K
authors.lastname: Ma
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: Yuzhu
authors.initials: Y
authors.lastname: Song
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: Yue
authors.initials: Y
authors.lastname: Feng
authors.affiliation: b Department of Clinical Laboratory , The People's Hospital of LuXi County in Yunnan Province , Yunnan , China .
authors.forename: Haiping
authors.initials: H
authors.lastname: Duan
authors.affiliation: c Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense , Second Military Medical University , Shanghai , China , and.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: Binghui
authors.initials: B
authors.lastname: Wang
authors.affiliation: c Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense , Second Military Medical University , Shanghai , China , and.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: d Department of Clinical Laboratory , The First People's Hospital of Yunnan Province , Yunnan , China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming, Yunnan , China .
authors.forename: Xueshan
authors.initials: X
authors.lastname: Xia
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000235:genetics; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D056915:DNA Copy Number Variations / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D054629:Genome, Mitochondrial / Q000235:genetics; D006526:Hepatitis C / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D008076:Cholesterol, HDL; D004272:DNA, Mitochondrial; D001219:Aspartate Aminotransferases
keywords: AST; HCV patients; HDL-C; male; mtDNA copy numbers