title: Antitumor and Wound Healing Properties of Rubus ellipticus Smith.
abstract: The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to in vitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher in vitro antioxidant activity, was taken for the evaluation of in vivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2 g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13(th) day and the 19(th) day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56 cm(3)). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: Blassan Plackal
authors.initials: BP
authors.lastname: George
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India. Electronic address: drparimel@gmail.com.
authors.forename: Thangaraj
authors.initials: T
authors.lastname: Parimelazhagan
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: Yamini T
authors.initials: YT
authors.lastname: Kumar
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore, Tamil Nadu, India.
authors.forename: Thankarajan
authors.initials: T
authors.lastname: Sajeesh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D065856:Rubus / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D010936:Plant Extracts
keywords: Rubus ellipticus; antioxidant; antitumor; wound healing