title: Treated Autoimmune Thyroid Disease Is Associated with a Decreased Quality of Life among Young Persons with Type 1 Diabetes.
abstract: Type 1 diabetes (T1D) in children and adolescents is relatively often accompanied by other immunopathological diseases, autoimmune thyroid disease (AITD) or celiac disease (CD). Our aim was to assess whether these conditions are associated with changes in the health-related quality of life (HRQOL) in pediatric patients with T1D. In a cross-sectional study we identified eligible 332 patients with T1D aged 8-18 years, of whom 248 (75%) together with their parents responded to the PedsQL Generic and Diabetes Modules. Compared to 143 patients without thyroid autoantibodies, 40 patients with a thyroxine-treated AITD scored lower in the overall generic HRQOL (P = 0.014), as well as in the overall diabetes-specific HRQOL (P = 0.013). After adjustment for age, gender, duration of diabetes, type of diabetes treatment, and diabetes control, this association remained statistically significant for the generic HRQOL (P = 0.023). Celiac disease was not associated with a change in the generic or diabetes-specific HRQOL (P = 0.07  and  P = 0.63, resp.). Parental scores showed no association with AITD or celiac disease, except a marginally significant decrease in the overall generic HRQOL (P = 0.039) in the T1D + AITD compared to T1D group. Our study indicates that, in pediatric patients with T1D, concomitant thyroxine-treated AITD is associated with lower quality of life.
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic ; Department of Psychology, Faculty of Arts, Charles University in Prague, 11000 Prague, Czech Republic.
authors.forename: Alena
authors.initials: A
authors.lastname: Spirkova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Petra
authors.initials: P
authors.lastname: Dusatkova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic ; Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, 11800 Prague, Czech Republic.
authors.forename: Monika
authors.initials: M
authors.lastname: Peckova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Stanislava
authors.initials: S
authors.lastname: Kolouskova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Marta
authors.initials: M
authors.lastname: Snajderova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Obermannova
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Katerina
authors.identifier: 0000-0003-4101-0603
authors.initials: K
authors.lastname: Stechova
authors.affiliation: Department of Psychology, Faculty of Arts, Charles University in Prague, 11000 Prague, Czech Republic.
authors.forename: Tamara
authors.initials: T
authors.lastname: Hrachovinova
authors.affiliation: Department of Social Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50038 Hradec Kralove, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Mares
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Cinek
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Jan
authors.identifier: 0000-0002-3365-5375
authors.initials: J
authors.lastname: Lebl
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Sumnik
authors.affiliation: Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital in Motol, V Uvalu 84, 15006 Prague, Czech Republic.
authors.forename: Stepanka
authors.identifier: 0000-0001-8019-8026
authors.initials: S
authors.lastname: Pruhova