title: Sarar Cohort: disease activity, functional capacity, and radiological damage in rheumatoid arthritis patients undergoing total hip and knee arthroplasty.
abstract: OBJECTIVE
  The Sarar cohort consists of patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) who underwent hip or knee arthroplasties at hospital Sarah-Brasília. The objective of this study was to evaluate clinical and laboratory factors associated with disease activity, functional capacity and radiological damage in RA patients, participants in this cohort.
  
  
  METHODS
  cross-sectional study, with data collection achieved from medical records review.
  
  
  RESULTS
  Thirty-two patients were included, with a mean time of disease onset of 240 months. Nineteen patients underwenttotal knee (TKA) and 17 total hip (THA) arthroplasty. There was a positive correlation between maximum dose of methotrexate (MTX) and Clinical Disease Activity Index (CDAI) (R = -0.46, p = 0.011), and a negative one with Simplified Erosion and Narrowing Score (SENS) (R = - 0.58, p = 0.004). SENS values were higher in patients with rheumatoid factor (RF) (p = 0.005) and anti-cyclic citrullinated peptide antibody 3 (anti-CCP3) positivity (p = 0.044), in those with higher RF (p = 0.037) and anti-CCP3 (p = 0.025) titers, and lower in patients with family history of RA (p = 0.009). HAQ values were higher in older patients (p = 0.031). In multiple linear regression, only "maximum dose of MTX' and "family history" remained with significant association with SENS (r(2) = 0.73, p <0.001 for both variables). In the model evaluating CDAI only "maximum dose of MTX" remained significantly associated (r(2) = 0.35, p = 0.016).
  
  
  CONCLUSIONS
  In the Sarar cohort, clinical and laboratory factors were related to disease activity, functional capacity and radiological damage, similar to studies evaluating patients with lower disease duration.
authors.affiliation: Hospital SARAH, Brasília, DF, Brasil. Electronic address: bmcunha@sarah.br.
authors.forename: Bernardo Matos da
authors.initials: BM
authors.lastname: Cunha
authors.affiliation: Hospital SARAH, Brasília, DF, Brasil.
authors.forename: Sandro Barbosa de
authors.initials: SB
authors.lastname: Oliveira
authors.affiliation: Clínica Médica, Universidade de Brasília, Brasília, DF, Brasil.
authors.forename: Leopoldo Luiz dos
authors.initials: LL
authors.lastname: Santos-Neto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001171:Arthritis, Juvenile / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001938:Brazil; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
keywords: Arthroplasty; Artrite reumatoide; Artroplastia; Capacidade funcional; Dano radiológico; Functional capacity; Radiological damage; Rheumatoid arthritis