title: Spirastrellolide E: Synthesis of an advanced C(1)-C(24) southern hemisphere.
abstract: The synthesis of a C(1)-C(24) advanced southern hemisphere fragment towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chemistry (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
authors.forename: Alexander
authors.initials: A
authors.lastname: Sokolsky
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
authors.forename: Xiaozhao
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, 19104.
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
keywords: Anion Relay Chemistry; Brook Rearrangement; Gold Catalysis; Spirastrellolide; Total Synthesis