title: Variations in adjuvant chemotherapy and survival in women with epithelial ovarian cancer - a population-based study.
abstract: BACKGROUND
  To investigate whether variations in primary chemotherapy were associated with survival in a nationally complete cohort of Australian women with epithelial ovarian cancer (EOC).
  
  
  METHODS
  All 1192 women diagnosed with invasive EOC in Australia in 2005 were identified through state-based cancer registries. Medical record information including details of primary chemotherapy treatment was obtained and survival data updated in 2012. Those started on standard chemotherapy (carboplatin and paclitaxel given at three-weekly intervals) after primary cytoreductive surgery were included (n = 351) and the relative dose intensity (RDI) was calculated. Time interval between surgery and start of chemotherapy was analysed in weeks. Hazard ratios [HR, 95% confidence interval (CI)] were calculated using multivariable Cox proportional hazards models.
  
  
  RESULTS
  Compared to women with RDI of 91-100%, those with RDI of ≤ 70% had significantly poor survival (HRadj = 1.62, 95% CI 1.05-2.49). This association was stronger among women with advanced (FIGO stage III/IV) disease at diagnosis (HRadj = 1.90, 95% CI 1.22-2.96). The interval between primary surgery and chemotherapy was not related to survival (HRadj = 0.98, 95% CI 0.93-1.03 for every week of delay), at least up to a period of five weeks.
  
  
  CONCLUSIONS
  Our results suggest that RDI of 70% or less was associated with poorer survival, particularly in women with advanced stage EOC. In contrast, the interval duration between primary surgery and chemotherapy was not related to survival, irrespective of disease stage or residual disease. These results provide some reassurance that, at least up until five weeks post-surgery, timing of chemotherapy commencement has a negligible effect on survival.
authors.affiliation: a The University of Queensland, School of Public Health , Brisbane , Queensland , Australia.|b The QIMR Berghofer Medical Research Institute, Gynaecological Cancers Group , Brisbane , Queensland , Australia.
authors.forename: Satyamurthy
authors.initials: S
authors.lastname: Anuradha
authors.affiliation: b The QIMR Berghofer Medical Research Institute, Gynaecological Cancers Group , Brisbane , Queensland , Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Donovan
authors.affiliation: b The QIMR Berghofer Medical Research Institute, Gynaecological Cancers Group , Brisbane , Queensland , Australia.
authors.forename: Penelope M
authors.initials: PM
authors.lastname: Webb
authors.affiliation: c Department of Gynaecological Oncology , Westmead Hospital, University of Sydney , Westmead, New South Wales , Australia.
authors.forename: Alison H
authors.initials: AH
authors.lastname: Brand
authors.affiliation: d Royal Brisbane and Women's Hospital , Brisbane , Queensland , Australia.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Goh
authors.affiliation: e Department of Medical Oncology , Prince of Wales Hospital , Sydney , New South Wales , Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Friedlander
authors.affiliation: f Department of Gynaecological Oncology , Royal Adelaide Hospital , Adelaide , South Australia , Australia.
authors.forename: Martin K
authors.initials: MK
authors.lastname: Oehler
authors.affiliation: g Department of Obstetrics and Gynaecology University of Melbourne , Melbourne , Victoria , Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Quinn
authors.affiliation: h Border Medical Oncology , Wodonga , Victoria , Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Steer
authors.affiliation: b The QIMR Berghofer Medical Research Institute, Gynaecological Cancers Group , Brisbane , Queensland , Australia.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Jordan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001315:Australia; D016190:Carboplatin / Q000008:administration & dosage; D000077216:Carcinoma, Ovarian Epithelial; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000401:mortality* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality* / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage; D016016:Proportional Hazards Models; D013997:Time Factors
chemical_list: D016190:Carboplatin; D017239:Paclitaxel