title: Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir.
abstract: Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.
authors.affiliation: Division of Infectious Diseases, Department of Medicine.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Collins
authors.affiliation: Department of Medicine.
authors.forename: Kara Loren
authors.initials: KL
authors.lastname: Raphael
authors.affiliation: Department of Medicine.
authors.forename: Charles
authors.initials: C
authors.lastname: Terry
authors.affiliation: Division of Infectious Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Cartwright
authors.affiliation: Division of Digestive Diseases, Department of Medicine Emory Transplant Center, Emory University School of Medicine.
authors.forename: Anjana
authors.initials: A
authors.lastname: Pillai
authors.affiliation: Division of Digestive Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Anania
authors.affiliation: Division of Infectious Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Farley
mesh_terms: D000284:Administration, Oral; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D060085:Coinfection; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006515:Hepatitis B virus / Q000502:physiology*; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D000069616:Simeprevir / Q000008:administration & dosage / Q000627:therapeutic use*; D000069474:Sofosbuvir / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D000069616:Simeprevir; D000069474:Sofosbuvir
keywords: HBV reactivation; HBV/HCV coinfection; acute hepatitis; simeprevir; sofosbuvir