title: Mitodiversity.
abstract: Here, in addition to the previously coined term "mitobiota", we introduce the term "mitodiversity" for various phenotypic and genetic heterogeneities of mitochondria within the same cell or organ. Based on data on the mitochondrial transmembrane potential determined both in situ and in vitro under normal conditions and after organ ischemia/reperfusion, such heterogeneity is most evident under pathologic conditions. Herein, a part of the mitochondrial population with transmembrane potential typical of the normal state is sustained even under a pathological condition that, perhaps, underlies the development of ways of reversing pathology back to the normal state. The membrane potentials of isolated mitochondria were shown to directly correlate with the magnitude of side-scattered light depicting internal structure of mitochondria. We analyzed possible interpretations of data on mitochondrial membrane potential obtained using fluorescent probes. We suggest a possible mechanism underlying retention of fluorescent probes inside the cells and mitochondria.
authors.affiliation: Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Popkov
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: K G
authors.initials: KG
authors.lastname: Lyamzaev
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: L D
authors.initials: LD
authors.lastname: Zorova
authors.forename: I B
authors.initials: IB
authors.lastname: Pevzner
authors.forename: S S
authors.initials: SS
authors.lastname: Jankauskas
authors.forename: S D
authors.initials: SD
authors.lastname: Zorov
authors.forename: V A
authors.initials: VA
authors.lastname: Babenko
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology