title: Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children.
abstract: The outcome of romiplostim for secondary failure of platelet recovery (SFPR) was investigated in children who had undergone hematopoietic stem cell transplantation (HSCT). Seven transfusion-dependent pediatric patients (median age 11 years), with platelet counts below 10 × 10(9)/L, received four weekly doses of subcutaneous romiplostim to treat SFPR developed after HSCT. All patients, except one (patient 4), became platelet transfusion-independent in the second week from the beginning of treatment and no patient needed to discontinue drug treatment because of adverse events. Romiplostim could represent a beneficial first-line treatment, but further studies are required.
authors.affiliation: Bone Marrow Transplantation Unit, Pediatric Hemato Oncology Department, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell'Istria 65, 34134, Trieste, Italy. natalia.maximova@burlo.trieste.it.
authors.forename: Natalia
authors.initials: N
authors.lastname: Maximova
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Pharmacy and Clinical Pharmacology, Trieste, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Zanon
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Pharmacy and Clinical Pharmacology, Trieste, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rovere
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Pharmacy and Clinical Pharmacology, Trieste, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Maestro
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Pharmacy and Clinical Pharmacology, Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Schillani
authors.affiliation: Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Pharmacy and Clinical Pharmacology, Trieste, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Paparazzo
mesh_terms: D000293:Adolescent; D064591:Allografts; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D010976:Platelet Count; D011961:Receptors, Fc / Q000008:administration & dosage*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage*; D013921:Thrombocytopenia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013926:Thrombopoietin / Q000008:administration & dosage*
chemical_list: D011961:Receptors, Fc; D011993:Recombinant Fusion Proteins; D013926:Thrombopoietin; C488777:romiplostim
keywords: Pediatric patients; Romiplostim; Secondary failure of platelet recovery; Virus infection