title: [Deaths due to non-AIDS diseases among HIV infected patients: A 14-year study (1998-2011)].
abstract: OBJECTIVE
  The objective of this study was to analyze the deaths caused by non-AIDS diseases in a cohort of HIV-infected patients treated between 1998 and 2011.
  
  
  METHODS
  Information on the causes of death was collected retrospectively, and then classified according to the deaths code (CoDe) algorithm. Patient characteristics and causes of death were compared for two periods: 1998-2004 and 2005-2011.
  
  
  RESULTS
  A total of 159 out of the 1070 patients cared for in study period died, 56 (35%) due to AIDS events and 86 (54%) due to non-AIDS events (NAEs); in 17 (11%) the cause of death could not be determined. Overall, the main causes of death were infections (32%), cancer (17%), and unnatural deaths (17%). There was lower mortality from AIDS-related conditions during the second period (18.5% vs 47%; P<.001) and higher mortality from NAEs (68% vs 45%; P=.006). There was a very sharp increase in non-AIDS-defining cancers (18.5% vs 2.1%, p=001), and increased deaths from cardiovascular disease (9.2% vs 2.1%, P=.06). Patients who died in the second period were older, and had a better immunological and virological status at cohort entry and before death. They received antiretroviral therapy (ART) more often and were more often virologically suppressed before death (61.5% vs 24%; P=.001).
  
  
  CONCLUSIONS
  Non-AIDS-defining cancers, unnatural deaths, and cardiovascular diseases are now major causes of death in patients with HIV. In recent years the majority of deceased patients are on ART and with virological suppression.
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: López
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España. Electronic address: marmasiac@gmail.com.
authors.forename: Mar
authors.initials: M
authors.lastname: Masiá
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: Sergio
authors.initials: S
authors.lastname: Padilla
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Aquilino
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bas
authors.affiliation: Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante, España.
authors.forename: Félix
authors.initials: F
authors.lastname: Gutiérrez
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality*; D002423:Cause of Death; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality*
keywords: AIDS diseases; Comorbidity; Comorbilidades; Complicaciones; Complications; Enfermedades no sida; Enfermedades oportunistas; Human immunodeficiency virus; Mortalidad; Mortality; Non-AIDS diseases; Opportunistic infections; Sida; Virus de la inmunodeficiencia humana