title: Increased expression of metastasis-associated in colon cancer-1 in renal cell carcinoma is associated with poor prognosis.
abstract: Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P < 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P < 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of The 1st Urology, The 2nd Hospital of Dalian Medical University Dalian, People's Republic of China.
authors.forename: Naijin
authors.initials: N
authors.lastname: Xu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Kai
authors.initials: K
authors.lastname: Guo
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Pengju
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Xiezhao
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Abai
authors.initials: A
authors.lastname: Xu
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University Guangzhou, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors
keywords: MACC1; biomarker; prognosis; renal cell carcinoma