title: Concise Review: Quiescence in Adult Stem Cells: Biological Significance and Relevance to Tissue Regeneration.
abstract: Adult stem cells (ASCs) are tissue resident stem cells responsible for tissue homeostasis and regeneration following injury. In uninjured tissues, ASCs exist in a nonproliferating, reversibly cell cycle-arrested state known as quiescence or G0. A key function of the quiescent state is to preserve stemness in ASCs by preventing precocious differentiation, and thus maintaining a pool of undifferentiated ASCs. Recent evidences suggest that quiescence is an actively maintained state and that excessive or defective quiescence may lead to compromised tissue regeneration or tumorigenesis. The aim of this review is to provide an update regarding the biological mechanisms of ASC quiescence and their role in tissue regeneration.
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, Karnataka, India.|Manipal University, Manipal, Karnataka, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rumman
authors.affiliation: Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, Karnataka, India.|CSIR-Center for Cell and Molecular Biology (CCMB), Hyderabad, Telangana, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Dhawan
authors.affiliation: Laboratory for Molecular Endocrinology (KMEB), Department of Endocrinology and Metabolism, University Hospital of Odense, Odense, Denmark.|Danish Stem Cell Center (DanStem), Panum Institute, University of Copenhagen, Copenhagen, Denmark.|Stem cell Unit, Department of Anatomy, College of Medicine, King Saud University, Kingdom of Saudi Arabia.
authors.forename: Moustapha
authors.initials: M
authors.lastname: Kassem
mesh_terms: D053687:Adult Stem Cells; D059447:Cell Cycle Checkpoints / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D006706:Homeostasis; D006801:Humans; D012038:Regeneration / Q000235:genetics*; D014945:Wound Healing / Q000235:genetics
keywords: Adult stem cells; Cell cycle; Differentiation; Hematopoietic stem cells; Marrow stromal cells; Muscle stem cells; Quiescence