title: Classification of drug tablets using hyperspectral imaging and wavelength selection with a GAWLS method modified for classification.
abstract: Right drug tablets must be brought to the right places. We apply hyperspectral imaging, which can measure infrared spectra at many points on a two-dimensional plane, to classify tablets correctly. The k-nearest neighbor algorithm (kNN) is employed to classify tablets using a database including their spectra and true classes. Although classification accuracy is not 100%, we can correctly classify tablets overall, since spectra at many points are measured with spectroscopy and misclassification at some points does not have much influence on the final tablet classification result. In addition, we propose a wavelength selection method for classification. Genetic algorithm-based wavelength selection is applied to classification and combined with kNN, and thus, not wavelengths but wavelength-regions can be selected in classification problems. Through a case study, we confirmed that the proposed method could classify three kinds of tablets correctly and select appropriate wavelength-regions.
authors.affiliation: Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kaneko
authors.affiliation: Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: funatsu@chemsys.t.u-tokyo.ac.jp.
authors.forename: Kimito
authors.initials: K
authors.lastname: Funatsu
mesh_terms: D000465:Algorithms; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013607:Tablets / Q000737:chemistry* / Q000145:classification*
chemical_list: D013607:Tablets
keywords: Classification; Hyperspectral imaging; Tablets; Variable selection; Wavelength selection; k-Nearest neighbor