title: Activity of superoxide dismutase copper/zinc type and prognosis in a cohort of patients with coronary artery disease.
abstract: OBJECTIVE
  Superoxide dismutase (SOD) is important to control reactive oxygen species, but the relevance to human disease like coronary artery disease (CAD) and underlying ischemia/reperfusion injury is not clarified.
  
  
  METHODS
  For this study, 2239 patients with known CAD were prospectively followed with a median follow-up time period of 3.6 years and a maximum of 6.9 years. During follow-up cardiovascular death was reported in 103 cases.
  
  
  RESULTS
  SOD activity (log-transformed) was investigated as continuous and categorical variable, showing a significant influence on outcome in the fully adjusted model (p = 0.045).
  
  
  CONCLUSIONS
  Increased SOD activity beyond the normal range in the human physiology is related to an adverse outcome in patients with CAD.
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Elvin
authors.initials: E
authors.lastname: Zengin
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Sinning
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Zeller
authors.affiliation: Department of Medicine II, GPR Rüsselsheim, Rüsselsheim, Germany.
authors.forename: Hans-J
authors.initials: HJ
authors.lastname: Rupprecht
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Renate B
authors.initials: RB
authors.lastname: Schnabel
authors.affiliation: Institute of Clinical Chemistry & Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
authors.forename: Karl-J
authors.initials: KJ
authors.lastname: Lackner
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Blankenberg
authors.affiliation: Department of General & Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Westermann
authors.affiliation: Department of Internal Medicine, Federal Armed Forces Central Hospital, Koblenz, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Bickel
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D015415:Biomarkers; D013482:Superoxide Dismutase
keywords: coronary artery disease; ischemia/reperfusion; outcome; oxidative stress; superoxide dismutase