title: Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China.
abstract: The association of systemic antioxidant activity with ambient air pollution has been unclear. A panel of 40 healthy college students underwent repeated blood collection for 12 occasions under three exposure scenarios before and after relocating from a suburban area to an urban area in Beijing, China in 2010-2011. We measured various air pollutants including fine particles (PM2.5) and determined circulating levels of antioxidant enzymes extracellular superoxide dismutase (EC-SOD) and glutathione peroxidase 1 (GPX1) in the laboratory. An interquartile range increase of 63.4 μg/m(3) at 3-d PM2.5 moving average was associated with a 6.3% (95% CI: 0.6, 12.4) increase in EC-SOD and a 5.5% (95% CI: 1.3, 9.8) increase in GPX1. Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Our results support activation of circulating antioxidant enzymes following exposure to particulate air pollution.
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Wu
authors.affiliation: Institute of Reproductive & Child Health, Peking University School of Public Health, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Di
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Chanjuan
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Public Health, Hyogo College of Medicine, Hyogo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shima
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China. Electronic address: lotus321321@126.com.
authors.forename: Furong
authors.initials: F
authors.lastname: Deng
authors.affiliation: Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China.
authors.forename: Xinbiao
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D000068476:Beijing; D002681:China; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009566:Nitrates / Q000097:blood; D010316:Particle Size; D052638:Particulate Matter / Q000032:analysis*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D009566:Nitrates; D052638:Particulate Matter; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Air pollution; Antioxidant enzyme; Chemical constituent; Particulate matter