title: IgE anti-respiratory syncytial virus antibodies detected in serum of pediatric patients with asthma.
abstract: Respiratory syncytial virus (RSV) causes lower respiratory tract disease in infants and young children, and is a public health concern, as is the increase in pediatric asthma. Respiratory viral infections may trigger asthma exacerbations. However, it remains unknown whether RSV infection may have a specific association with asthma. Total serum IgE, and IgE- and IgG-anti-RSV Ab responses were studied in older asthmatic compared with non-asthmatic children (M/F, mean age: 14) (N=30, N=43, respectively). We found: (1) total serum IgE was higher in asthmatic compared with non-asthmatics (P<0.001); (2) total serum IgE did correlate with IgE anti-RSV Abs (P<0.001), and with IgG anti-RSV Abs (P=0.008) in all subjects; (3) total serum IgE levels did correlate with IgE anti-RSV in asthmatics (P=0.047), but not in non-asthmatics (P=0.13); (4) IgE anti-RSV Abs did correlate with IgG anti-RSV Abs in all subjects (P=0.001); (5) IgE- and IgG-anti RSV Abs were higher in asthma compared with no asthma (P=0.003; <0.001, respectively); (6) there was a significant association between age and IgE anti-RSV in non-asthma (P=0.008), but not in asthma (P=0.64). Our findings indicate that IgE-anti-RSV Ab responses may play important roles in RSV infection and asthma.
authors.affiliation: Department of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States; Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States. Electronic address: tamar.smith-norowitz@downstate.edu.
authors.forename: Tamar A
authors.initials: TA
authors.lastname: Smith-Norowitz
authors.affiliation: Department of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Mira
authors.initials: M
authors.lastname: Mandal
authors.affiliation: Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States; Dept. of Medicine, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Rauno
authors.initials: R
authors.lastname: Joks
authors.affiliation: Department of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Levana T
authors.initials: LT
authors.lastname: Norowitz
authors.affiliation: Department of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Diana
authors.initials: D
authors.lastname: Weaver
authors.affiliation: Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States; Dept. of Pathology, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Helen G
authors.initials: HG
authors.lastname: Durkin
authors.affiliation: Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Bluth
authors.affiliation: Department of Pediatrics, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States; Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY, 11203, United States.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kohlhoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D001249:Asthma / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D012136:Respiratory Syncytial Viruses / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007073:Immunoglobulin E
keywords: Asthma; IgE; Respiratory syncytial virus