title: CancerHSP: anticancer herbs database of systems pharmacology.
abstract: The numerous natural products and their bioactivity potentially afford an extraordinary resource for new drug discovery and have been employed in cancer treatment. However, the underlying pharmacological mechanisms of most natural anticancer compounds remain elusive, which has become one of the major obstacles in developing novel effective anticancer agents. Here, to address these unmet needs, we developed an anticancer herbs database of systems pharmacology (CancerHSP), which records anticancer herbs related information through manual curation. Currently, CancerHSP contains 2439 anticancer herbal medicines with 3575 anticancer ingredients. For each ingredient, the molecular structure and nine key ADME parameters are provided. Moreover, we also provide the anticancer activities of these compounds based on 492 different cancer cell lines. Further, the protein targets of the compounds are predicted by state-of-art methods or collected from literatures. CancerHSP will help reveal the molecular mechanisms of natural anticancer products and accelerate anticancer drug development, especially facilitate future investigations on drug repositioning and drug discovery. CancerHSP is freely available on the web at http://lsp.nwsuaf.edu.cn/CancerHSP.php.
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Weiyang
authors.initials: W
authors.lastname: Tao
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Bohui
authors.initials: B
authors.lastname: Li
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Gao
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Yaofei
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Piar Ali
authors.initials: PA
authors.lastname: Shar
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Zihu
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Sun
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Yingxue
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Huang
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Jiexin
authors.initials: J
authors.lastname: Mu
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Tianli
authors.initials: T
authors.lastname: Pei
authors.affiliation: Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1] Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, Shaanxi 712100, China [2] Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Pharmacy School, Shihezi University, Ministry of Education, Shihezi, Xinjiang 832002, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002681:China; D016208:Databases, Factual; D055808:Drug Discovery; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D004365:Drugs, Chinese Herbal