title: Copper(ii) complexes of macrocyclic and open-chain pseudopeptidic ligands: synthesis, characterization and interaction with dicarboxylates.
abstract: Mono- and dinuclear Cu(ii) complexes were prepared with pseudopeptidic open chain and macrocyclic ligands, respectively. They were characterized by UV-vis spectroscopy, EPR, HRMS and X-ray diffraction. The Cu(ii) cation is coordinated by two amines and two deprotonated amides, in a slightly distorted square planar coordination geometry. The complexes interact with several substituted dicarboxylates, as shown by UV-vis titrations and EPR experiments. The interaction of both mono- and dinuclear complexes with very similar dicarboxylates of biological interest (malate and aspartate) resulted in strikingly different outcomes: in the first case a ternary complex [ligand...metal...dicarboxylate] was obtained almost quantitatively, while in the latter, the Cu(ii) displacement to form Cu(Asp)2 was predominant.
authors.affiliation: Departamento de Química Biológica y Modelización Molecular, IQAC-CSIC, Jordi Girona, 16-26, E-08034 Barcelona, Spain. enrico.faggi@iqac.csic.es ignacio.alfonso@iqac.csic.es.
authors.forename: Enrico
authors.initials: E
authors.lastname: Faggi
authors.forename: Raquel
authors.initials: R
authors.lastname: Gavara
authors.forename: Michael
authors.initials: M
authors.lastname: Bolte
authors.forename: Lluís
authors.initials: L
authors.lastname: Fajarí
authors.forename: Luís
authors.initials: L
authors.lastname: Juliá
authors.forename: Laura
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Alfonso
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D008293:Malates / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D008293:Malates; D001224:Aspartic Acid; D003300:Copper; C030298:malic acid