title: Multimodal Analgesia in Total Knee Arthroplasty: A Randomized, Double-Blind, Controlled Trial on Additional Efficacy of Periarticular Anesthesia.
abstract: Pain management is a main determinant of functional recovery after total knee arthroplasty (TKA). We performed a randomized, controlled, double blind study to evaluate additive efficacy of periarticular anesthesia in patients undergoing TKA in reducing post-operative pain, operated limb edema and improving post-operative mobility. Patients were randomly assigned to study or control group; all subjects received the same analgesic protocol; before wound closure, the study group received also a periarticular anesthesia (ropivacaine 1% 20 mL). The results show no statistical differences in any of the variable evaluated. Our data suggest that additive periarticular anesthetic protocol with ropivacaine 1% 20 mL is not superior to oral and intravenous analgesia alone in patients undergoing TKA, regarding post-operative pain control, operated limb edema reduction and post-operative mobility improvement.
authors.affiliation: Physical and Rehabilitation Medicine Resident Program, Università degli Studi, Turin, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Milani
authors.affiliation: Orthopaedics Unit, Clinica La Vialarda, Biella, Italy.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Castelli
authors.affiliation: Orthopaedics Unit, Clinica La Vialarda, Biella, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Sola
authors.affiliation: Physical Medicine and Rehabilitation Unit, Azienda Ospedaliero Universitaria Maggiore della Carità, Health Sciences Department-Amedeo Avogadro University, Novara, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Invernizzi
authors.affiliation: Ortophaedics, Traumatology and Rehabilitation Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Massazza
authors.affiliation: Physical Medicine and Rehabilitation Unit, Azienda Ospedaliero Universitaria Maggiore della Carità, Health Sciences Department-Amedeo Avogadro University, Novara, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Cisari
mesh_terms: D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000698:Analgesia / Q000379:methods; D000700:Analgesics / Q000008:administration & dosage; D000758:Anesthesia; D000772:Anesthesia, Local / Q000379:methods / Q000706:statistics & numerical data*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee; D004311:Double-Blind Method; D004487:Edema / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D059408:Pain Management; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D016059:Range of Motion, Articular; D000077212:Ropivacaine
chemical_list: D000577:Amides; D000700:Analgesics; D000779:Anesthetics, Local; D000077212:Ropivacaine
keywords: analgesia; arthroplasty; knee replacement; outcome; periarticular injection; range of motion