title: Comparative effects of hawthorn (Crataegus pinnatifida Bunge) pectin and pectin hydrolyzates on the cholesterol homeostasis of hamsters fed high-cholesterol diets.
abstract: This study aims to compare the effects of feeding haw pectin (HP), haw pectin hydrolyzates (HPH), and haw pectin pentasaccharide (HPPS) on the cholesterol metabolism of hypercholesterolemic hamsters induced by high-cholesterol diets. The animals were fed a standard diet (SD), high-cholesterol diet (HCD), or HCD plus HP, HPH, or HPPS at a dose of 300mg/kg body weight for 4weeks. Results showed that HPPS was more effective than HP and HPH in decreasing the body weight gain (by 38.2%), liver weight (by 16.4%), and plasma and hepatic total cholesterol (TC; by 23.6% and 27.3%, respectively) of hamsters. In addition, the bile acid levels in the feces were significantly higher by 39.8% and 132.8% in the HPH and HPPS groups than in the HCD group. Such changes were not noted in the HP group. However, the HP group had higher cholesterol excretion capacities than the HPH and HPPS groups by inhibiting cholesterol absorption in the diet, with a 21.7% increase in TC excretion and a 31.1% decrease in TC absorption. Thus, HPPS could be a promising anti-atherogenic dietary ingredient for the development of functional food to improve cholesterol metabolism.
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China. Electronic address: zhurugang@lnu.edu.cn.
authors.forename: Ru-Gang
authors.initials: RG
authors.lastname: Zhu
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Yan-Di
authors.initials: YD
authors.lastname: Sun
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Tuo-Ping
authors.initials: TP
authors.lastname: Li
authors.affiliation: Forestry Biotechnology and Analysis Test Center, Liaoning Academy of Forestry Sciences, Shenyang 110032, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Duan
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Zheng-Zheng
authors.initials: ZZ
authors.lastname: Zheng
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Shu-Lei
authors.initials: SL
authors.lastname: Shi
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Jing-Guo
authors.initials: JG
authors.lastname: Xu
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Department of Food Science, Liaoning University, Liaoning Engineering Research Center for Food Bioprocessing, Shenyang Key Laboratory of Food Bioprocessing and Quality Control, Shenyang 110036, China.
authors.forename: Xiao-Yi
authors.initials: XY
authors.lastname: Jin
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000032:analysis / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D027825:Crataegus / Q000737:chemistry / Q000378:metabolism*; D006224:Cricetinae; D059305:Diet, High-Fat; D005243:Feces / Q000737:chemistry; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010368:Pectins / Q000378:metabolism / Q000494:pharmacology*; D010936:Plant Extracts / Q000378:metabolism / Q000494:pharmacology*; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D008076:Cholesterol, HDL; D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D010368:Pectins; D002784:Cholesterol
keywords: Cholesterol homeostasis; Hamster; Haw pectin; Haw pectin hydrolyzates; Haw pectin pentasaccharide