title: The effect of antacid on salivary pH in patients with and without dental erosion after multiple acid challenges.
abstract: OBJECTIVE
  To evaluate the effect of antacid swish in the salivary pH values and to monitor the pH changes in subjects with and without dental erosion after multiple acid challenge tests.
  
  
  METHODS
  20 subjects with tooth erosion were matched in age and gender with 20 healthy controls according to specific inclusion/exclusion criteria. Baseline measures were taken of salivary pH, buffering capacity and salivary flow rate using the Saliva Check System. Subjects swished with Diet Pepsi three times at 10-minute intervals. Changes in pH were monitored using a digital pH meter at 0-, 5-, and 10- minute intervals and at every 5 minutes after the third swish until pH resumed baseline value or 45 minutes relapse. Swishing regimen was repeated on a second visit, followed by swishing with sugar-free liquid antacid (Mylanta Supreme). Recovery times were also recorded. Data was analyzed using independent t-tests, repeated measures ANOVA, and Fisher's exact test (α= 0.05).
  
  
  RESULTS
  Baseline buffering capacity and flow rate were not significantly different between groups (P= 0.542; P= 0.2831, respectively). Baseline salivary pH values were similar between groups (P= 0.721). No significant differences in salivary pH values were found between erosion and non-erosion groups in response to multiple acid challenges (P= 0.695) or antacid neutralization (P= 0.861). Analysis of salivary pH recovery time revealed no significant differences between groups after acid challenges (P= 0.091) or after the use of antacid (P= 0.118). There was a highly significant difference in the survival curves of the two groups on Day 2, with the non-erosion group resolving significantly faster than the erosion group (P= 0.0086).
authors.forename: Sarah
authors.initials: S
authors.lastname: Dhuhair
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Dennison
authors.forename: Peter
authors.initials: P
authors.lastname: Yaman
authors.forename: Gisele F
authors.initials: GF
authors.lastname: Neiva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D002021:Buffers; D002253:Carbonated Beverages / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors; D014077:Tooth Erosion / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D000863:Antacids; D002021:Buffers