title: Vitamin E modulates lung oxidative stress, serum copper, zinc, and iron levels in rats with pulmonary contusion.
abstract: OBJECTIVE
  To evaluate the effects of oxidant/antioxidant mechanisms and levels of trace elements on trauma-stimulated moderate pulmonary contusions after vitamin E administration.
  
  
  METHODS
  Sixty-three male Sprague Dawley rats were used. Animals were studied in 4 groups. Vitamin E (150 mg/kg) was injected intraperitoneally 30 min after trauma and on the first and second days. Blood samples were obtained for nitric oxide (NO) levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Zinc (Zn+2), copper (Cu+2), and iron (Fe+3) were measured in serum.
  
  
  RESULTS
  Lung contusion increased serum and tissue NO levels and SOD activities and decreased GSH-Px activities (P < 0.05). Vitamin E significantly (P < 0.05) decreased NO levels and SOD activities and increased GSH-Px. Serum Zn+2, Cu+2, and Fe+3 levels were statistically significantly influenced by the administration of vitamin E (P < 0.05). Group 4 had lower scores compared to Group 3 (P < 0.05) and no difference compared to Group 1 (P > 0.05).
  
  
  CONCLUSIONS
  These results suggest that treatment with vitamin E reduces lung oxidative stress and related mechanisms in isolated lung contusion as demonstrated by an experimental rat model.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sirmali
authors.forename: Okan
authors.initials: O
authors.lastname: Solak
authors.forename: Talip
authors.initials: T
authors.lastname: Çevik
authors.forename: Rana
authors.initials: R
authors.lastname: Sirmali
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Özaydin
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Giniş
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Ağaçkiran
authors.forename: Namık
authors.initials: N
authors.lastname: Delibaş
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003300:Copper / Q000097:blood; D007501:Iron / Q000097:blood; D055370:Lung Injury / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014131:Trace Elements / Q000097:blood; D016896:Treatment Outcome; D014810:Vitamin E / Q000494:pharmacology; D015032:Zinc / Q000097:blood
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D014810:Vitamin E; D003300:Copper; D007501:Iron; D013482:Superoxide Dismutase; D015032:Zinc