title: [Agranulocytosis related to fluindione: A case report].
abstract: BACKGROUND
  While in most countries warfarin is the preferred anti-vitamin K, fluindione, a molecule with a prolonged half-life remains largely prescribed in France. Some of its side effects, including immuno-allergic complications, remain poorly understood.
  
  
  METHODS
  A 77-year-old woman presented with a febrile severe neutropenia of immunoallergic mechanism with a favourable outcome associated with fluindione, introduced 25 days earlier for the treatment of atrial fibrillation.
  
  
  CONCLUSIONS
  This rare side effect is a reminder of the importance of biological monitoring in the first weeks following the introduction of fluindione and key diagnostic elements and therapeutic aspects of iatrogenic agranulocytosis.
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France. Electronic address: stephanie.ngo@chu-rouen.fr.
authors.forename: S
authors.initials: S
authors.lastname: Ngo
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Benhamou
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Armengol
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Sauvêtre
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Cailleux-Talbot
authors.affiliation: Pharmacovigilance, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: N
authors.initials: N
authors.lastname: Massy
authors.affiliation: Hématologie biologique, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Buchonnet
authors.affiliation: Département de médecine interne, CHU Rouen, 1, rue de Germont, 76031 Rouen cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Lévesque
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000473:pathology; D000925:Anticoagulants / Q000009:adverse effects*; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000473:pathology; D004342:Drug Hypersensitivity / Q000473:pathology; D005260:Female; D005602:France; D006801:Humans; D010630:Phenindione / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000925:Anticoagulants; D010630:Phenindione; C017673:fluindione
keywords: Agranulocytose; Agranulocytosis; Fluindione