title: Differences between coagulation and cytokine profiles in dogs of different ages.
abstract: In human medicine, age is a risk factor for thromboembolic diseases associated with hypercoagulable and antifibrinolytic states, but information in veterinary medicine is limited. This study compared the thromboelastometric (TEM) profiles of two groups of dogs of distinct ages. Ten healthy old (>10 years) Beagles and 10 healthy young (<3 years) Beagles were recruited. White blood cell counts and haematocrit were significantly lower in the old group compared to the young group, and fibrinogen, total proteins, globulins and monocyte chemoattractant protein-1 plasma concentrations were significantly higher in the old group. Comparisons of the TEM profiles indicated a hypercoagulable profile and a decrease in fibrinolytic activity in all old Beagles. The findings support the need to consider age as a possible risk factor for thrombosis in dogs.
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France. Electronic address: anthony.barthelemy@vetagro-sup.fr.
authors.forename: A
authors.initials: A
authors.lastname: Barthélemy
authors.affiliation: Laboratoire de Biologie Médicale, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France.
authors.forename: B
authors.initials: B
authors.lastname: Rannou
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France.
authors.forename: M
authors.initials: M
authors.lastname: Forterre
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; Critical and Intensive Care and Anaesthesia, Veterinary School of Toulouse, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Verwaerde
authors.affiliation: EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Bonnet-Garin
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France.
authors.forename: C
authors.initials: C
authors.lastname: Pouzot-Nevoret
authors.affiliation: Intensive Care Unit (SIAMU), VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France; EA4174 Sepsis, Inflammation, Hémostase, VetAgro Sup Campus Vétérinaire de Lyon, Université de Lyon, Marcy l'Etoile, France.
authors.forename: I
authors.initials: I
authors.lastname: Goy-Thollot
mesh_terms: D000375:Aging; D000818:Animals; D001777:Blood Coagulation; D016207:Cytokines / Q000097:blood*; D004285:Dogs; D005260:Female; D008297:Male; D012307:Risk Factors; D013916:Thrombelastography / Q000662:veterinary*; D013927:Thrombosis / Q000209:etiology / Q000662:veterinary*
chemical_list: D016207:Cytokines
keywords: Ageing; Coagulation; Cytokines; Dog; Thromboelastometry