title: Successful Immunosuppressive Therapy for Severe Infectious Mononucleosis in a Patient with Clonal Proliferation of EBV-infected CD8-positive Cells.
abstract: A 30-year-old woman was diagnosed with severe infectious mononucleosis (IM). The Epstein-Barr virus (EBV) had infected both CD19- and CD8-positive cells, and clonal proliferation of EBV-infected cells and T-cells was detected. Although we suspected malignant lymphoma, her condition improved following immunosuppressive therapy. A similar case was recently reported; therefore, this case is the second case of IM with EBV-infected CD8-positive cells and clonal proliferation of EBV-infected cells. Our results demonstrate that the clonal proliferation of EBV-infected cells is not always an indication for chemotherapy in the primary infection phase and that monitoring the EBV viral load is useful for therapeutic decision-making.
authors.affiliation: Hematology/Oncology, Wakayama Medical University, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hosoi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sonoki
authors.forename: Shogo
authors.initials: S
authors.lastname: Murata
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mushino
authors.forename: Kodai
authors.initials: K
authors.lastname: Kuriyama
authors.forename: Akinori
authors.initials: A
authors.lastname: Nishikawa
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Hanaoka
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Imadome
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakakuma
mesh_terms: D000328:Adult; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000821:virology*; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007244:Infectious Mononucleosis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents