title: Involvement of Mζ-Like Protein Kinase in the Mechanisms of Conditioned Food Aversion Memory Reconsolidation in the Helix lucorum.
abstract: We studied the involvement of Mζ-like protein kinase (PKMζ) into mechanisms of conditioned food aversion memory reconsolidation in Helix lucorum. Injections PKMζ inhibitor ZIP in a dose of 5 mg/kg on day 2 or 10 after learning led to memory impairment and amnesia development. Injections of the inhibitor in doses of 1.5 or 2.5 mg/kg had no effect. Repeated training on day 11 after induction of amnesia resulted in the formation of memory on the same type of food aversion similar to first training. The number of combinations of conditional (food) and reinforcing (electrical shock) stimuli was similar during initial and repeated training. We hypothesize that the inhibition of Mζ-like protein kinase erases the memory trace and a new memory is formed during repeated training.
authors.affiliation: P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Solntseva
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D004558:Electric Stimulation; D005247:Feeding Behavior / Q000502:physiology*; D006372:Helix, Snails / Q000378:metabolism / Q000502:physiology*; D000069077:Memory Consolidation / Q000502:physiology*; D057567:Memory, Long-Term / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism*; D000099221:Protein Kinase C zeta
chemical_list: D011493:Protein Kinase C; D000099221:Protein Kinase C zeta