title: Resistance exercise induces a greater irisin response than endurance exercise.
abstract: OBJECTIVE
  We determined detailed time-course changes in the irisin response to acute exercise using different exercise modes.
  
  
  METHODS
  In experiment 1, seven healthy males rested for 12h (8:00-20:00) to determine the diurnal variation in plasma irisin concentration. In experiment 2, 10 healthy males conducted three exercises to clarify time-course changes in plasma irisin concentration over 6h, using a randomized crossover design. The resistance exercise (R) trial consisted of eight exercises of 12 repetitions with 3-4 sets at 65% of one repetition maximum (1RM). The endurance exercise (E) trial consisted of 60 min of pedaling at 65% of maximal oxygen uptake (VO2max). In the combined mode (R+E) trial, 30 min of endurance exercise was preceded by 30 min of resistance exercise.
  
  
  RESULTS
  In experiment 1, no significant changes in plasma irisin concentration were observed over 12h. In experiment 2, the R trial showed a marked increase in plasma irisin concentration 1h after exercise (P<0.05), but not in the E or R+E trials. The area under the curve (AUC) for irisin concentrations for 6h after exercise was significantly higher in the R trial than in the R+E trial (P<0.05). The AUC for irisin concentrations was significantly correlated with AUC values for blood glucose, lactate, and serum glycerol (r=0.37, 0.45, 0.45, respectively. P<0.05).
  
  
  CONCLUSIONS
  Resistance exercise resulted in significantly greater irisin responses compared with endurance exercise alone, and resistance and endurance exercises combined.
authors.affiliation: Graduate School of Sport and Health Science, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tsuchiya
authors.affiliation: Faculty of Education and Human Sciences, University of Yamanashi, 4-4-37, Takeda, Kofu, Yamanashi, 400-8510, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ando
authors.affiliation: University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takamatsu
authors.affiliation: Graduate School of Sport and Health Science, Ritsumeikan University, 1-1-1, Nojihigashi, Kusatsu, Shiga, 525-8577, Japan. Electronic address: kagoto@fc.ritsumei.ac.jp.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Goto
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000378:metabolism; D002940:Circadian Rhythm; D015444:Exercise / Q000502:physiology*; D005353:Fibronectins / Q000097:blood*; D005990:Glycerol / Q000097:blood; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D055070:Resistance Training; D055815:Young Adult
chemical_list: D001786:Blood Glucose; C577593:FNDC5 protein, human; D005353:Fibronectins; D019344:Lactic Acid; D005990:Glycerol
keywords: Exercise mode; FNDC5; Irisin; PGC-1α; Time-course change