title: Caries lesion prevention and arrestment in approximal surfaces in contact with glass ionomer cement restorations - A systematic review and meta-analysis.
abstract: BACKGROUND
  Studies have suggested that in the presence of approximal cavities, the approximal surface in contact with this one shows a higher risk in the development of caries lesions.
  
  
  OBJECTIVE
  To evaluate the ability of dental materials to prevent and to arrest caries lesion in approximal surfaces in contact with occlusoproximal restorations.
  
  
  METHODS
  Two independent reviewers performed a literature search in PubMed through November 2014. The inclusion criteria were: (1) subject related to the scope of this systematic review, (2) study with follow-up, (3) not performed in specific groups, (4) to have a comparison group. After selection by title and abstract, potentially eligible articles were read in full. Meta-analysis was carried out considering the outcome as caries lesion progression or arrestment.
  
  
  RESULTS
  The search strategy identified 772 potentially relevant studies, and 10 of them were included in the review (six laboratory studies and four longitudinal trials). For the longitudinal clinical trials, no difference was verified among the materials (OR = 0.680,95%CI:0.233-1.983). When a meta-analysis was performed for laboratory studies, GIC was significantly associated with better ability to arrest caries lesions (OR = 0.153,95%CI:0.060-0.391).
  
  
  CONCLUSIONS
  In laboratory studies, GIC shows better ability to arrest caries lesion in approximal adjacent surfaces, but this ability was not confirmed in longitudinal clinical trials.
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Tamara Kerber
authors.initials: TK
authors.lastname: Tedesco
authors.affiliation: Department of Cariology, Endodontology and Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, Netherlands.
authors.forename: Clarissa Calil
authors.initials: CC
authors.lastname: Bonifácio
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Ana Flávia Bissoto
authors.initials: AF
authors.lastname: Calvo
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Thais
authors.initials: T
authors.lastname: Gimenez
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Mariana Minatel
authors.initials: MM
authors.lastname: Braga
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, University of São Paulo, São Paulo, Brazil.
authors.forename: Daniela Prócida
authors.initials: DP
authors.lastname: Raggio
mesh_terms: D002648:Child; D003731:Dental Caries / Q000517:prevention & control*; D058250:Dental Restoration Repair; D018450:Disease Progression; D005899:Glass Ionomer Cements; D006801:Humans
chemical_list: D005899:Glass Ionomer Cements