title: Control of mammalian gene expression by selective mRNA export.
abstract: Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking transcription in the nucleus to translation in the cytoplasm. Although important components of the mRNA export machinery are well characterized, such as transcription-export complexes TREX and TREX-2, recent work has shown that, in some instances, mammalian mRNA export can be selective and can regulate crucial biological processes such as DNA repair, gene expression, maintenance of pluripotency, haematopoiesis, proliferation and cell survival. Such findings show that mRNA export is an unexpected, yet potentially important, mechanism for the control of gene expression and of the mammalian transcriptome.
authors.affiliation: Medical Research Centre (MRC) Cancer Unit, Hutchison/MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK.
authors.forename: Vihandha O
authors.initials: VO
authors.lastname: Wickramasinghe
authors.affiliation: Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Laskey
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D005090:Exodeoxyribonucleases / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008322:Mammals / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D012261:Ribonucleoproteins; D005090:Exodeoxyribonucleases