title: Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis.
abstract: There has been significant progress in our understanding of the pathogenesis of AS. The advent of genome-wide association studies has increased the known loci associated with AS to more than 40. The endoplasmic reticulum resident aminopeptidases (ERAP) 1 and 2 were identified in this manner and are of particular interest. There appears to be a genetic as well as a functional interaction of ERAP1 and 2 with HLA-B27 based on the known functions of these molecules. Recent studies on the structure, immunological effects and the peptide-trimming properties of ERAP 1 and 2 have helped to provide insight into their pathogenic potential in AS. In this review, we explore the role of ERAP 1 and 2 in the pathogenesis of AS.
authors.affiliation: The University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane.
authors.forename: Tony J
authors.initials: TJ
authors.lastname: Kenna
authors.affiliation: Centre for Neurogenetics and Statistical Genomics, Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Robinson
authors.affiliation: Division of Rheumatology, University of Toronto and University Health Network, Toronto, Ontario, Canada nigil.haroon@uhn.ca.
authors.forename: Nigil
authors.initials: N
authors.lastname: Haroon
mesh_terms: D000626:Aminopeptidases / Q000235:genetics / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology; D015796:HLA-B27 Antigen / Q000235:genetics / Q000502:physiology; D006801:Humans; D015778:Minor Histocompatibility Antigens; D013167:Spondylitis, Ankylosing / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*
chemical_list: D015796:HLA-B27 Antigen; D015778:Minor Histocompatibility Antigens; D000626:Aminopeptidases; C464841:ERAP1 protein, human; C503944:ERAP2 protein, human
keywords: NK cell; T cell response; aminopeptidase; endoplasmic reticulum; endoplasmic reticulum resident aminopeptidase 1; endoplasmic reticulum resident aminopeptidase 2; misfolding; peptide; unfolded protein response