title: Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis.
abstract: In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4(+)CD161(+)IL-17A(+) Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4(+)CD25(+)FoxP3(+) Treg lymphocytes with immunosuppressive activity.
authors.affiliation: Department of Pathophysiology, Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia, kononova.te@gmail.com.
authors.forename: T E
authors.initials: TE
authors.lastname: Kononova
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: V V
authors.initials: VV
authors.lastname: Novitskii
authors.forename: Yu V
authors.initials: YV
authors.lastname: Kolobovnikova
authors.forename: E G
authors.initials: EG
authors.lastname: Churina
authors.forename: P A
authors.initials: PA
authors.lastname: Zakharova
mesh_terms: D000328:Adult; D015704:CD4 Antigens / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000378:metabolism; D018709:Statistics, Nonparametric; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C527203:KLRB1 protein, human; D055651:NK Cell Lectin-Like Receptor Subfamily B; D016212:Transforming Growth Factor beta