title: Clinical Features of Neonates with Hydrops Fetalis.
abstract: OBJECTIVE
  The objective of this study was to evaluate the clinical characteristics of neonates with hydrops fetalis to improve recognition of the disease.
  
  
  METHODS
  The clinical data of 10 neonates with hydrops fetalis were retrospectively studied. Prenatal characteristics, causes, clinical features, and prognosis were explored.
  
  
  RESULTS
  Eight neonates presenting abnormal nonstress test suffered from severe neonatal asphyxia at birth and were resuscitated by endotracheal intubation. Nine had skin edema, eight had pleural effusions with one unilateral and seven bilateral. Six had ascites, eight had polyhydramnios, one had multiple malformations and one had chromosome abnormalities. One survived and nine died. Six died due to resuscitation failure in delivery room, two died due to giving up after 1 day and one died due to the treatment failure after 6 months. Causes of hydrops fetalis were a congenital diaphragmatic hemangioma, recurrent atrial premature beats, genetic syndrome suspicious, Down syndrome, congenital pulmonary lymphangiectasia, anemia, paroxysmal supraventricular tachycardia, placental chorioangioma, and idiopathic edema.
  
  
  CONCLUSIONS
  The prognosis varied because of different etiologies of hydrops fetalis. Severe cases frequently had skin edema and high rate of asphyxia at birth and difficult resuscitation. Timely intrauterine interventions were helpful for successful resuscitation. A well-prepared resuscitation team and the effectiveness of resuscitation could correlate to increasing survival rate.
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: An
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Jimei
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Jiale
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Neonatology, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Chengqiu
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Prenatal Diagnosis Center, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Prenatal Diagnosis Center, Gynecology and Obstetrics Hospital of Fudan University, Shanghai, China.
authors.forename: Yingliu
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000328:Adult; D002971:Cleft Lip / Q000000981:diagnostic imaging / Q000503:physiopathology; D015331:Cohort Studies; D004314:Down Syndrome; D004487:Edema / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008297:Male; D009333:Neck / Q000002:abnormalities; D006831:Polyhydramnios / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D012151:Resuscitation; D012189:Retrospective Studies; D012871:Skin Diseases / Q000503:physiopathology*; D000069258:Thoracentesis; D016216:Ultrasonography, Prenatal