title: Human Papillomavirus Test for Triage of Japanese Women With Low-Grade Squamous Intraepithelial Lesions.
abstract: We evaluated high-risk human papillomavirus (HR-HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) lesions by cobas HPV test and diagnostic HPV16/18 genotyping in Japanese women with low-grade squamous intraepithelial lesions. Of 357 patients, HR-HPV positivity prevalence was 75.6%, and 21.3% had grade 2 or higher CIN lesions (CIN2+), with the highest prevalence at 30 to 34 years. Negative predictive values of HR-HPV for CIN2+ in our patients were 93.1% (any age) and 94.9% (40-50 years). Absolute risk for CIN2+ in HR-HPV positive and HPV16/18 positive individuals was 25.9 and 35.1, respectively. Relative risk for CIN2+ lesions was 5.1 for HPV16/18 positive versus HR-HPV negative, and 3.8 for HR-HPV positive versus HR-HPV negative women. Predictive values of CIN2+ positive were higher for HPV16/18 positive women (any age) than 12 other HPV positive-genotypes, and highest (50%) at 40-50 years. The HPV16/18 genotyping might prevent women (>40 years) at risk of high-grade CIN lesions from undergoing unnecessary colposcopy/overtreatment of nonprogressive lesions.
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan iwatatakashi@1995.jukuin.keio.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwata
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Hasegawa
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ochiai
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Takizawa
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Umezawa
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuramoto
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Mineo
authors.initials: M
authors.lastname: Ohmura
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Kaneyuki
authors.initials: K
authors.lastname: Kubushiro
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Arai
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Sakamoto
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Teiichi
authors.initials: T
authors.lastname: Motoyama
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D044466:Asian People; D004279:DNA, Viral / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D060787:Neoplasm Grading; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology / Q000821:virology; D011237:Predictive Value of Tests; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D065310:Squamous Intraepithelial Lesions of the Cervix / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology / Q000821:virology; D014218:Triage / Q000379:methods*; D019564:Unnecessary Procedures; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral
keywords: cervical intraepithelial neoplasia; cobas HPV test; high-risk human papillomavirus; low-grade squamous intraepithelial lesions