title: Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies.
abstract: Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications.
authors.affiliation: Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
authors.forename: Marco
authors.initials: M
authors.lastname: Deiana
authors.affiliation: Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Matczyszyn
authors.affiliation: Laboratoire de Chimie, CNRS UMR 5182, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Massin
authors.affiliation: Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Olesiak-Banska
authors.affiliation: Laboratoire de Chimie, CNRS UMR 5182, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Andraud
authors.affiliation: Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Samoc
mesh_terms: D003512:Cyclohexanones / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; D007364:Intercalating Agents; C005940:isophorone; D004247:DNA