title: The studies about doxorubicin-loaded p(N-isopropyl-acrylamide-co-butyl methylacrylate) temperature-sensitive nanogel dispersions on the application in TACE therapies for rabbit VX2 liver tumor.
abstract: Transarterial chemo-embolization (TACE), which combined embolization therapy and chemotherapy, has become the most widely used treatment for unresectable liver cancer. Blood-vessel-embolic materials play key role on TACE. In the present work, doxorubicin-loaded p(N-isopropylacrylamide-co-butyl methylacrylate) nanogels-iohexol dispersions (IBi-D) were reported firstly for TACE therapy to liver cancer. Using inverting-vial method, IBi-D dispersions showed three phases (swollen gel, flowable sol and shrunken gel) as temperature increased. Although Dox had little effect on the CGTs between flowable and shrunken gel, the rheological properties of IBi-D dispersions could greatly improved by Dox. A sustained Dox-release, which was necessary in TACE therapy, was found from IBi-D dispersions in the eluting medium of PBS buffers. The studies about renal artery embolization of normal rabbits indicated that IBi-D dispersions showed good properties in embolizing all kinds of renal arteries (including peripheral, small and large arteries) by controlling their injecting dosages. Angiography and medical evaluation indicated that TACE therapy of IBi-D dispersions has better efficacy on rabbit VX2 liver tumors than TAC treatment of free Dox and TAE treatment of IBi dispersions.
authors.affiliation: Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang RD, Wuhan 430022, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Ma
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Jiangshan
authors.initials: J
authors.lastname: Wan
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Shinan
authors.initials: S
authors.lastname: Geng
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Li
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Qianwen
authors.initials: Q
authors.lastname: Fu
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Xiaole
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang RD, Wuhan 430022, PR China.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Kan
authors.affiliation: Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang RD, Wuhan 430022, PR China.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Zhou
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang RD, Wuhan 430022, PR China. Electronic address: herrxiong@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Xiong
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China. Electronic address: zhaoyb@hust.edu.cn.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Interventional Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang RD, Wuhan 430022, PR China. Electronic address: hqzcsxh@sina.com.
authors.forename: Chuansheng
authors.initials: C
authors.lastname: Zheng
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan City, PR China.
authors.forename: HuiBi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D004621:Embolization, Therapeutic; D005260:Female; D005782:Gels; D056945:Hep G2 Cells; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000737:chemistry; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D049329:Nanostructures / Q000008:administration & dosage* / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D011817:Rabbits; D012077:Renal Artery; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D005782:Gels; D011109:Polymethacrylic Acids; C052970:poly-N-isopropylacrylamide; D007472:Iohexol; D004317:Doxorubicin; C068872:polybutyl methacrylate
keywords: Blood-vessel-embolic materials; Controlled release; Doxorubicin; TACE; Temperature sensitive nanogels