title: [Advance in studies on natural antidepressant drugs and cytochrome P450].
abstract: In the fast pace of modern life and under the heavy work pressure, the prevalence of depression has increased year by year. Meanwhile, the demands for antidepressant drugs have also grown, especially the high-efficiency and low-toxicity natural antidepressant drugs, mainly including polyphenols, flavonoids, organic acids, alkaloids and terpenoids. Cytochrome P450 (CYP450) is a type of enzymes involving oxidative metabolism of drugs in vivo, and can change the pharmacokinetics and efficacy of drugs. Therefore, it is of important significant to define the effect of natural antidepressant drugs on CYP450 in human bodies, in order to improve the rational clinical medication, avoid drug interactions and reduce adverse reactions.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Fei-hu
authors.initials: FH
authors.lastname: Wang
authors.forename: Sai-zhen
authors.initials: SZ
authors.lastname: Chen
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Pan
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003863:Depression / Q000188:drug therapy / Q000201:enzymology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans
chemical_list: D000928:Antidepressive Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D004365:Drugs, Chinese Herbal; D003577:Cytochrome P-450 Enzyme System