title: [Sclerosing acral skin perineurioma: clinicopathologic study of ten cases (eight classical and two with xanthomatous changes)].
abstract: BACKGROUND
  Perineurioma is an infrequent and benign cutaneous neoplasm characterized by proliferation of perineurial cells. It is classified into two main types: intraneural and the extraneural or soft tissue perineurioma, in which the sclerosing variant is included. Sclerosing perineurioma is more frequently found on acral skin. Clinically, they are well-circumscribed,skin colored, nodular tumors.
  
  
  OBJECTIVE
  Describe and communicate clinicopathologic findings from a case series of sclerosing acral perineurioma.
  
  
  METHODS
  This is a clinical, morphological and immunohistologic case study of eight patients with the diagnosis of sclerosing perineurioma.
  
  
  RESULTS
  It included five men and five women, with ages ranging between nine and 66 years. All of them had lesion on acral skin. At microscopy study, the lesions showed a proliferation of epithelioid and spindle-shaped perineurial cells, arranged in small aggregates and short fascicles between thickened collagen bundles. Immunohistochemistry studies revealed that the proliferating cells expressed EMA, Claudin-1 and Glut-1, and were negative for S-100 protein.
  
  
  CONCLUSIONS
  It is important to report these infrequent skin tumors, so they can be taken into account in the differential diagnoses of acral lesions.
authors.affiliation: Servicio de Dermatología y Dermatopatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Sonia
authors.initials: S
authors.lastname: Toussaint-Caire
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Adriana
authors.initials: A
authors.lastname: Aguilar-Donis
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Torres-Guerrero
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Daniel
authors.initials: D
authors.lastname: Asz-Sigall
authors.affiliation: Servicio de Dermatología y Dermatopatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: María Elisa
authors.initials: ME
authors.lastname: Vega-Memije
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Lacy-Niebla
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Judith
authors.initials: J
authors.lastname: Domínguez-Cherit
authors.affiliation: Servicio de Dermatología, Hospital Dr. Manuel Gea González, México, D.F., México.
authors.forename: Patricia
authors.initials: P
authors.lastname: Alfaro Ledesma
authors.affiliation: Departamento de Patología Quirúrgica y Molecular, Centro Médico ABC, México. D.F., México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ortiz-Hidalgo
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D062445:Claudin-1 / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000473:pathology*; D012598:Sclerosis / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014973:Xanthomatosis / Q000175:diagnosis / Q000473:pathology*
chemical_list: D062445:Claudin-1; D051272:Glucose Transporter Type 1; D018396:Mucin-1