title: [Advances in the researches of lutein and alzheimer's disease].
abstract: Lutein, a kind of oxycarotenoid, can pass the blood brain barrier and preferentially accumulate in the human brain, which is the most abundant carotenoid in human brain. Evidence from multiple studies suggested that lutein was closely related to age-related cognitive decline and risk of Alzheimer's disease (AD) in human. Dietary, plasma and brain concentrations of lutein were negatively associated with age-related cognitive decline. Lutein concentrations in plasma and brain were significantly lower in AD patients than those of health control. In human brain, lutein was the sole carotenoid which consistently associated with a range of cognitive function measures. In elderly women, lutein supplement can improve the cognitive function. In this article, we systematically reviewed the literature on the role of lutein in age-related cognitive decline and alzheimer's disease and its possible mechanisms. It may prove some benefit information for the advanced research and prevention of AD.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Hangzhou Normal University, Hangzhou 310036, China.
authors.forename: Xianrong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Email: xmlin1987@bjmu.edu.cn.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Lin
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D001921:Brain; D002338:Carotenoids; D003071:Cognition; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D014975:Lutein
chemical_list: D002338:Carotenoids; D014975:Lutein