title: Retrospective Evaluation of New Chinese Diagnostic Scoring System for Disseminated Intravascular Coagulation.
abstract: OBJECTIVE
  To retrospectively validate the new Chinese DIC scoring system (CDSS).
  
  
  METHODS
  This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from International Society on Thrombosis and Haemostasis (ISTH), Japanese Association for Acute Medicine (JAAM) and Japanese Ministry of Health and Welfare (JMHW), and evaluated its prognostic value by 28 days mortality, APACHE II and SOFA score.
  
  
  RESULTS
  In non-hematologic malignancies, CDSS was more specific than JAAM (72.55% vs. 50.49%, p<0.05) and more sensitive than ISTH (77.07% vs. 62.03%, p<0.05). In hematologic malignancies, the area under the ROC curve of CDSS was larger than ISTH and JMHW (0.933 vs. 0.889, p<0.01 with ISTH, 0.944 vs. 0.845, p<0.01 with JMHW). In addition, the 28-day mortality rate, SOFA scores, APACHE II scores of DIC patients diagnosed by CDSS were significantly greater than non-DIC (P <0.05).
  
  
  CONCLUSIONS
  We are the first group to propose CDSS. It emphasized the values of the clinical manifestations, the rapidly declining platelet count, APTT in the diagnosis of DIC and used D-dimer as the fibrin-related maker. DIC with hematological malignancies was treated as a special part. In this study we can see that CDSS displayed an acceptable property for the diagnosis of DIC with appropriate sensitivity and specificity, and also had a good prognostic value for DIC patients.
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Manzhi
authors.initials: M
authors.lastname: Wang
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Haiming
authors.initials: H
authors.lastname: Kou
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Huafang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Mei
authors.affiliation: Institute of Hematology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D003935:Diagnostic Techniques, Cardiovascular; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D006305:Health Status Indicators; D019337:Hematologic Neoplasms / Q000097:blood / Q000473:pathology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000473:pathology; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D