title: Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor.
abstract: High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS. Results. Mean age was 46 ± 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 ± 48 nmol/mL/min, and mean hsCRP was 2.1 ± 2.2 mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P = 0.03) and hsCRP (P < 0.0001) than those without MS. ROC curves showed that both markers predicted MS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects with MS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.
authors.affiliation: División de Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Octavo Piso, Santiago Centro, 8330024 Santiago, Chile.
authors.forename: Mónica
authors.initials: M
authors.lastname: Acevedo
authors.affiliation: Unidad de Prevención ACV y Rehabilitación Cardiaca, División de Cardiología y Cirugía Cardiaca, Hospital de la Dirección de Previsión de Carabineros de Chile, Vital Apoquindo 1200, 2°Piso, Las Condes, 7601003 Santiago, Chile.
authors.forename: Paola
authors.identifier: 0000-0002-4508-3490
authors.initials: P
authors.lastname: Varleta
authors.affiliation: División de Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Octavo Piso, Santiago Centro, 8330024 Santiago, Chile.
authors.forename: Verónica
authors.initials: V
authors.lastname: Kramer
authors.affiliation: División de Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Octavo Piso, Santiago Centro, 8330024 Santiago, Chile.
authors.forename: Giovanna
authors.identifier: 0000-0002-0203-6782
authors.initials: G
authors.lastname: Valentino
authors.affiliation: Departamento de Laboratorios Clínicos, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4686, Macul, 7820436 Santiago, Chile.
authors.forename: Teresa
authors.identifier: 0000-0003-4935-8276
authors.initials: T
authors.lastname: Quiroga
authors.affiliation: Laboratorio Clínico, Hospital de la Dirección de Previsión de Carabineros de Chile, Vital Apoquindo 1200, 2°Piso, Las Condes, 7601003 Santiago, Chile.
authors.forename: Carolina
authors.identifier: 0000-0002-3050-2701
authors.initials: C
authors.lastname: Prieto
authors.affiliation: Departamento de Laboratorios Clínicos, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4686, Macul, 7820436 Santiago, Chile.
authors.forename: Jacqueline
authors.identifier: 0000-0002-8636-1100
authors.initials: J
authors.lastname: Parada
authors.affiliation: División de Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Octavo Piso, Santiago Centro, 8330024 Santiago, Chile.
authors.forename: Marcela
authors.initials: M
authors.lastname: Adasme
authors.affiliation: Unidad de Prevención ACV y Rehabilitación Cardiaca, División de Cardiología y Cirugía Cardiaca, Hospital de la Dirección de Previsión de Carabineros de Chile, Vital Apoquindo 1200, 2°Piso, Las Condes, 7601003 Santiago, Chile.
authors.forename: Luisa
authors.initials: L
authors.lastname: Briones
authors.affiliation: Departamento de Matemáticas, Facultad de Ciencias, Universidad de la Serena, Avenida Raúl Bitrán Nachary s/n, 1700000 La Serena, Chile.
authors.forename: Carlos
authors.identifier: 0000-0002-2884-7882
authors.initials: C
authors.lastname: Navarrete