title: Association of ocular conditions with narrow angles in different ethnicities.
abstract: OBJECTIVE
  To quantify the predictive strength of anterior chamber area (ACA), anterior chamber volume (ACV), anterior chamber width (ACW), lens vault (LV), iris thickness (IT), and iris area (IArea) for 2 angle width parameters, trabecular-iris space area (TISA750) and angle opening distance (AOD750) at 750 μm from the scleral spur, in different ethnicities.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Anterior segment optical coherence tomography images for 166 white, 90 African, 75 Hispanic, and 132 Chinese subjects were analyzed. First, ACA, ACV, ACW, LV, IT, and IArea were compared among ethnic groups. Second, associations of TISA750 and AOD750 with ACA, ACV, ACW, LV, IT, and IArea were investigated within each ethnic group using multivariable linear regression models, standardized regression coefficients (β), and coefficients of determination (R(2)).
  
  
  RESULTS
  Significant ethnic differences were observed in ACA, ACV, ACW, LV, IT, and IArea (all P < .05). ACA, ACV, and LV were significant predictors of TISA750 and AOD750 in all ethnic groups (all P < .001). ACW and IT were significant predictors of AOD750 in white and African subjects (all P < .05). ACW and IT were significant predictors of TISA750 in white subjects (all P < .05). IArea was a significant predictor of AOD750 in Chinese (P < .05). ACA, ACV, and LV had the highest predictive strength for both TISA750 and AOD750 in all ethnic groups based on β and R(2).
  
  
  CONCLUSIONS
  Despite ethnic differences in ACA, ACV, ACW, LV, IT, and IArea, the same 3 anterior segment parameters (ACA, ACV, and LV) were the strongest predictors of angle width (TISA750 and AOD750) in all 4 ethnic groups.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Wake Forest University School of Medicine, Winston-Salem, North Carolina.
authors.forename: Roland Y
authors.initials: RY
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
authors.forename: Brian H
authors.initials: BH
authors.lastname: Chon
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
authors.forename: Shuai-Chun
authors.initials: SC
authors.lastname: Lin
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Mingguang
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, California. Electronic address: LinS@vision.ucsf.edu.
authors.forename: Shan C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D001741:Black or African American / Q000208:ethnology; D000368:Aged; D000867:Anterior Chamber / Q000473:pathology*; D044466:Asian People / Q000208:ethnology; D001699:Biometry; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000208:ethnology*; D006630:Hispanic or Latino / Q000208:ethnology; D006801:Humans; D007498:Iris / Q000473:pathology*; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D044465:White People / Q000208:ethnology