title: Premalignant alterations in breast and endometrium associated with a PTEN mutation in a woman with Cowden syndrome: implications for preventive care.
abstract: •This case report documents the in vivo process of malignant transformation in a patient with Cowden syndrome.•PTEN-driven oncogenesis may proceed through a stage of pre-invasive intra-epithelial neoplasm.•Our findings have important implications for preventive care and for pathologic sampling at the time of prophylactic surgery.
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Morse
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, United States.
authors.forename: Rochelle L
authors.initials: RL
authors.lastname: Garcia
authors.affiliation: Department of Surgery, University of Washington, Seattle, WA, United States.
authors.forename: Kristine E
authors.initials: KE
authors.lastname: Calhoun
authors.affiliation: Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Swisher
keywords: Cowden syndrome; Hereditary cancer; PTEN mutation