title: The Role of 25-Hydroxy Vitamin D Deficiency in Iron Deficient Children of North India.
abstract: Extensive data from animal and human studies indicate a role of vitamin D in erythropoiesis. Iron and vitamin D deficiencies are implicated with adverse health effects in children even if they are asymptomatic. The potential relationship between the two remains poorly understood. A cross-sectional study was performed in the period from 1st May 2012 through 30th April 2013 and subjects were classified into vitamin D deficiency (VDD), vitamin D insufficiency (VDI) and vitamin D sufficiency (VDS) groups according to their 25(OH) D levels. A total of 263 children were included in the analysis. Anaemia was present in 66 % of 25(OH) D deficient subjects compared with 35 % in vitamin D sufficient individuals (p < 0.0001). The association of breast feeding and development of VDD was also significant (p < 0.05). Serum levels of 25(OH) D were found lower in female sex and if the analysis was performed in the winter/spring season. Physicians should therefore assess vitamin D levels in all anaemic children and ensure adequate supplementation to prevent deficiencies.
authors.affiliation: Department of Biochemistry, Chacha Nehru Bal Chikitsalya Hospital, Associated to Maulana Azad Medical College, Geeta Colony, New Delhi, 110031 India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Pediatrics, Chacha Nehru Bal Chikitsalya Hospital, Associated to Maulana Azad Medical College, Geeta Colony, New Delhi, 110031 India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Jain
authors.affiliation: Department of Biochemistry, Chacha Nehru Bal Chikitsalya Hospital, Associated to Maulana Azad Medical College, Geeta Colony, New Delhi, 110031 India.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Dabla
keywords: Breast feeding; Children; Iron deficiency anaemia; Season; Supplementation; Vitamin D deficiency