title: β-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor.
abstract: The aim of this study was to examine β-arrestin1 expression in patients with lung adenocarcinoma (ADC) and explore the relationship of β-arrestin1 protein with clinicopathologic factors, vascular endothelial growth factor (VEGF) and prognosis. A total of 105 surgically resected lung adenocarcinoma patients were recruited for the study. The expression of β-arrestin1 and VEGF were determined by immunohistochemistry (IHC). The score measuring the β-arrestin1 and VEGF were calculated by combining the percentage of positive cells and the intensity of staining. Kaplan-Meier method and multivariable Cox proportional hazards regression analyses were used to examine the relationship between β-arrestin1 and survival. The results demonstrated that a notably higher level of β-arrestin1 expression was found in lung ADC tissues. We also found that an elevated nuclear Β-arrestin1 correlates with higher intratumoral VEGF (P = 0.007). β-arrestin 1 over-expression indicated a poor 5-year overall survival (P = 0.016), and the Cox regression model confirmed that β-arrestin1 over-expression were independent prognostic factor for tumor progression (P = 0.027) and unfavorable overall survival (P = 0.015). We conclude that β-arrestin1 had a high expression in ADC and β-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with ADC.
authors.affiliation: Institute of Oncology, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Chunlong
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Linhai
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Institute of Oncology, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Qu
authors.affiliation: Institute of Oncology, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Hongchang
authors.initials: H
authors.lastname: Shen
authors.affiliation: Institute of Oncology, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China ; Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Shandong University 324 Jingwu Road, Jinan 250021 P. R. China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Du
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D019390:Arrestins / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins
chemical_list: C000605253:ARRB1 protein, human; D019390:Arrestins; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D000071559:beta-Arrestin 1; D000071557:beta-Arrestins
keywords: VEGF; lung adenocarcinoma; prognosis; β-arrestin1