title: IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation.
abstract: We present a case of IgA nephropathy (IgAN) in monozygotic twins with excellent donor and recipient outcome 11 years after transplantation. The recipient developed IgAN at 26 years and progressed to end-stage renal failure 10 years later. His identical twin who had hypertension, intermittent microscopic haematuria and positive IgA immunofluorescence on biopsy became his donor. Eleven years following transplant, in the absence of immunosuppression, the recipient has stable graft function [estimated glomerular filtration rate (eGFR) 47 mL/min/1.73 m(2), Modification of Diet in Renal Disease (MDRD)], controlled hypertension on two medications and minor microscopic haematuria. The donor has good renal function (eGFR 51 mL/min/1.73 m(2), MDRD), controlled hypertension on one medication and normal urine.
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: John
authors.initials: J
authors.lastname: Irvine
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Cross
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Kelvin
authors.initials: K
authors.lastname: Lynn
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Richard
authors.initials: R
authors.lastname: Robson
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Martin
authors.initials: M
authors.lastname: Searle
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: John
authors.initials: J
authors.lastname: Morton
authors.affiliation: Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Sarah
authors.initials: S
authors.lastname: Armstrong
authors.affiliation: Department of Vascular, Endovascular and Transplant Surgery, Christchurch Hospital, Christchurch, New Zealand.
authors.forename: Justin
authors.initials: J
authors.lastname: Roake
keywords: IgA nephropathy; background; kidney; monozygotic twin; transplantation