title: Nuclear envelope: positioning nuclei and organizing synapses.
abstract: The nuclear envelope plays an essential role in nuclear positioning within cells and tissues. This review highlights advances in understanding the mechanisms of nuclear positioning during skeletal muscle and central nervous system development. New findings, particularly about A-type lamins and Nesprin1, may link nuclear envelope integrity to synaptic integrity. Thus synaptic defects, rather than nuclear mispositioning, may underlie human pathologies associated with mutations of nuclear envelope proteins.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.
authors.forename: David
authors.initials: D
authors.lastname: Razafsky
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA. Electronic address: hodzicd@vision.wustl.edu.
authors.forename: Didier
authors.initials: D
authors.lastname: Hodzic
mesh_terms: D000818:Animals; D001692:Biological Transport; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*
chemical_list: D009687:Nuclear Proteins