title: Distributions of colorectal cancer in two Chinese cities with contrasting colorectal cancer epidemiology.
abstract: OBJECTIVE
  The incidence of colorectal cancer (CRC) is rising rapidly in Chinese. We studied the anatomic distributions and characteristics of CRC in Hong Kong (HK) and Chongqing (CQ) with different CRC epidemiology.
  
  
  METHODS
  It was a retrospective study conducted in three large regional hospitals of the two cities. We identified all patients newly diagnosed with CRC between 2003 and 2012. The distribution and characteristics of CRC of the two cities were compared.
  
  
  RESULTS
  Of CRC, 3664 new cases were diagnosed within the study period. CRC was more common in men (>56%) in both cities. The mean age at diagnosis was significantly younger in CQ, the lower prevalence area, than in HK (62.1 vs 70.4 years; P < 0.001). Rectal cancer was the predominant (61.3%) cancer in CQ, but only 18% of cancers in HK were rectal cancer (P = 0.0001). Right-sided colonic cancer, however, was more common in HK than CQ (27.2% vs 17.4%; P < 0.001). Women had more right-sided colonic cancer than men in both cities (P < 0.002), and there was an age-related increase in right-sided colonic cancer in HK but not in CQ. Multivariate analysis showed that older age, female, and living in HK were independent risk factors associated with right-sided colonic cancer.
  
  
  CONCLUSIONS
  There are significant differences in the distribution of CRC between HK and CQ. The discrepancy may be partly accounted by older population and an increase in proximal colonic cancer, particularly in women, in HK.
authors.affiliation: Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: Wai K
authors.initials: WK
authors.lastname: Leung
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.|Department of Gastroenterology, The First People Hospital of Neijiang City, Neijiang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Long
authors.affiliation: Department of Surgery, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: W L
authors.initials: WL
authors.lastname: Law
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
keywords: colonoscopy; epidemiology; proximal colonic cancer; rectal cancer