title: Copper-Catalyzed Regioselective Hydroalkylation of 1,3-Dienes with Alkyl Fluorides and Grignard Reagents.
abstract: Copper complexes generated in situ from CuCl2, alkyl Grignard reagents, and 1,3-dienes play important roles as catalytic active species for the 1,2-hydroalkylation of 1,3-dienes by alkyl fluorides through C-F bond cleavage. The alkyl group is introduced to an internal carbon atom of the 1,3-diene regioselectively, thus giving rise to the branched terminal alkene product.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan). iwasaki@chem.eng.osaka-u.ac.jp.
authors.forename: Takanori
authors.initials: T
authors.lastname: Iwasaki
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan).
authors.forename: Ryohei
authors.initials: R
authors.lastname: Shimizu
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan).
authors.forename: Reiko
authors.initials: R
authors.lastname: Imanishi
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan).
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kuniyasu
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan). kambe@chem.eng.osaka-u.ac.jp.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kambe
keywords: alkylation; chemoselectivity; copper; magnesium; synthetic methods