title: Physiologically based arousal state estimation and dynamics.
abstract: A neural field model of the brain is used to represent brain states using physiologically based parameters rather than arbitrary, discrete sleep stages. Each brain state is represented as a point in a physiologically parametrized space. Over time, changes in brain state cause these points to trace continuous trajectories, unlike the artificial discrete jumps in sleep stage that occur with traditional sleep staging. The discrete Rechtschaffen and Kales sleep stages are associated with regions in the physiological parameter space based on their electroencephalographic features, which enables interpretation of traditional sleep stages in terms of physiological trajectories. Wake states are found to be associated with strong positive corticothalamic feedback compared to sleep. The existence of physiologically valid trajectories between brain states in the model is demonstrated. Actual trajectories for an individual can be determined by fitting the model using EEG alone, and enable analysis of the physiological differences between subjects.
authors.affiliation: School of Physics, University of Sydney, NSW 2006, Australia; Neurosleep, 431 Glebe Point Road, Glebe, NSW 2037, Australia; Cooperative Research Center for Alertness, Safety, and Productivity, University of Sydney, NSW 2006, Australia; Center for Integrated Research and Understanding of Sleep, Glebe, NSW 2037, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, NSW 2145, Australia. Electronic address: r.abeysuriya@physics.usyd.edu.au.
authors.forename: R G
authors.initials: RG
authors.lastname: Abeysuriya
authors.affiliation: School of Physics, University of Sydney, NSW 2006, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, NSW 2145, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Rennie
authors.affiliation: School of Physics, University of Sydney, NSW 2006, Australia; Neurosleep, 431 Glebe Point Road, Glebe, NSW 2037, Australia; Cooperative Research Center for Alertness, Safety, and Productivity, University of Sydney, NSW 2006, Australia; Center for Integrated Research and Understanding of Sleep, Glebe, NSW 2037, Australia; Brain Dynamics Center, Sydney Medical School - Western, University of Sydney, Westmead, NSW 2145, Australia; Center for Integrative Brain Function, University of Sydney, NSW 2006, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
mesh_terms: D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D005583:Fourier Analysis; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology; D017711:Nonlinear Dynamics; D012890:Sleep / Q000502:physiology
keywords: EEG; Modeling; Neural field theory; Neurophysiology; Sleep