title: A rabbit maxillary sinus model with simultaneous customized-implant placement: Comparative microscopic analysis for the evaluation of surface-treated implants.
abstract: We describe the use of a rabbit maxillary sinus model, characterized by thin osseous tissue and low bone density, for the evaluation of surface-treated implants by histologically and histomorphometrically comparing the osseointegration patterns depending on the surface treatment methods. Twenty rabbits were randomly assigned to two groups of 10 animals, one receiving 5 × 3 mm customized implants (machined, MA or sandblasted and acid etched, SLA) placed in sinus and the other receiving implants placed in a tibia. Histological observation of the implant placed in sinus shows relatively more active new bone formation, characterized by trabecular bone pattern underneath the cortical bone in sinus as compared with that in tibia. Histomorphometric analysis in the rabbits receiving implants in a tibia, the NBIC (%) associated with the SLA surface implant was greater than that associated with the MA implant at 2 weeks (55.63 ± 8.65% vs. 47.87 ± 10.01%; P > 0.05) and at 4 weeks (61.76 ± 9.49% vs. 42.69 ± 10.97%; P < 0.05). Among rabbits receiving implants in a sinus, the NBIC (%) associated with the SLA surface implant was significantly greater than that associated with the MA surface implant both at 2 weeks (37.25 ± 7.27% vs. 20.98 ± 6.42%; P < 0.05) and at 4 weeks (48.82 ± 6.77% vs. 31.51 ± 9.14%; P < 0.05). As a result, we suggest that the maxillary sinus model is an appropriate animal model for assessing surface-treated implants and may be utilized for the evaluation of surface-treated implants in poor bone quality environment. Microsc. Res. Tech. 78:697-706, 2015.
authors.affiliation: Department of Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Prosthodontics, Oral Science Research Center, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Hyunmin
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea.|Department of Stomatology, Affiliated Hospital of Yanbian University, Yanji, Jilin Province, China.
authors.forename: Sang-Bae
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Department of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul, Republic of Korea.|Department of Stomatology, Affiliated Hospital of Yanbian University, Yanji, Jilin Province, China.
authors.forename: Chenghao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Prosthodontics and Orthodontics, Health Science University Mongolia, Ulaanbaatar, Mongolia.|Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Jamiyandori
authors.initials: J
authors.lastname: Otgonbold
authors.affiliation: Department of Prosthodontics and Orthodontics, Health Science University Mongolia, Ulaanbaatar, Mongolia.|Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Jang-Gi
authors.initials: JG
authors.lastname: Cho
authors.affiliation: The Institute for the 3Rs & Department of Laboratory Animal Medicine, College of Veterinary Medicine & the Institute for the Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Han
mesh_terms: D000818:Animals; D015921:Dental Implants; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D008954:Models, Biological; D011817:Rabbits; D013499:Surface Properties
chemical_list: D015921:Dental Implants
keywords: Schneiderian membrane; dental implants; guided tissue regeneration; histology; sinus augmentation