title: Silver-Catalyzed Coupling of Two C sp(3)-H Groups and One-Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles.
abstract: Silver-catalyzed coupling of two C sp(3)-H groups to form 1,4-diketones have been developed for the first time. The resultant ketones then undergo cyclization to synthesize tetrasubstituted furans, thiophenes, and pyrroles from benzyl ketone derivatives in a one-pot reaction process. This highly-efficient synthetic method, which utilizes air as the terminal oxidant and readily accessible starting materials, displays a wide substrate scope and broad functional-group tolerance.
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069 (PR. China).
authors.forename: Shuai
authors.initials: S
authors.lastname: Mao
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069 (PR. China).
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069 (PR. China).
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Gao
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069 (PR. China).
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Guo
authors.affiliation: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069 (PR. China). wangyq@nwu.edu.cn.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Wang
keywords: CH activation; domino reactions; heterocycles; homogeneous catalysis; silver