title: Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine.
abstract: Recent studies demonstrated that mitochondria play an important role in the cardiovascular system and mutations of mitochondrial DNA affect coronary artery disease, resulting in hypertension, atherosclerosis, and cardiomyopathy. Traditional Chinese medicine (TCM) has been used for thousands of years to treat cardiovascular disease, but it is not yet clear how TCM affects mitochondrial function. By reviewing the interactions between the cardiovascular system, mitochondrial DNA, and TCM, we show that cardiovascular disease is negatively affected by mutations in mitochondrial DNA and that TCM can be used to treat cardiovascular disease by regulating the structure and function of mitochondria via increases in mitochondrial electron transport and oxidative phosphorylation, modulation of mitochondrial-mediated apoptosis, and decreases in mitochondrial ROS. However further research is still required to identify the mechanism by which TCM affects CVD and modifies mitochondrial DNA.
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China ; Clinical Medical College, Hubei University of Chinese Medicine, Wuhan 430065, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Clinical Medical College, Hubei University of Chinese Medicine, Wuhan 430065, China.
authors.forename: Fei
authors.identifier: 0000-0003-0130-9985
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Xing-Jiang
authors.initials: XJ
authors.lastname: Xiong
authors.affiliation: Clinical Medical College, Hubei University of Chinese Medicine, Wuhan 430065, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Fan