title: Acute Vilazodone Toxicity in a Pediatric Patient.
abstract: BACKGROUND
  Vilazodone is a selective serotonin reuptake inhibitor and 5HT1A agonist recently approved to treat depression in adults. To date, there are minimal data available regarding the expected course and treatment of acute vilazodone ingestions.
  
  
  METHODS
  We report a case of a previously healthy 19-month-old girl who presented after an acute ingestion of an estimated 37 mg/kg vilazodone. She was taken to an outside emergency department approximately 1 h after an unwitnessed ingestion. Initially, the patient was noted to have decreased responsiveness, sluggish but reactive pupils, altered mental status, and reported seizure activity. She was given intravenous lorazepam for seizure control, intubated, and transferred to a pediatric tertiary care facility, where she continued to show signs of serotonin toxicity and received treatment with benzodiazepines and cyproheptadine. Despite vilazodone's long half-life and the large amount ingested, the patient was extubated within 10 h of presentation, had returned to baseline mental status by 22 h, and was discharged home approximately 57 h after ingestion. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Accidental ingestions are common in the pediatric population. Emergency physicians need to be aware of the signs and symptoms of acute medication toxicities, the expected clinical course, and the necessary supportive measures used to treat these patients. Because vilazodone is a recently approved medication, there is little experience with acute vilazodone ingestions. This report considerably increases the understanding of vilazodone's effects in the setting of an acute ingestion.
authors.affiliation: Purdue University College of Pharmacy, Lafayette, Indiana.
authors.forename: Emily C
authors.initials: EC
authors.lastname: Acker
authors.affiliation: Department of Pharmacy, Riley Hospital for Children, Indianapolis, Indiana.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Sinclair
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Beardsley
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Sheikh S
authors.initials: SS
authors.lastname: Ahmed
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Blake A
authors.initials: BA
authors.lastname: Froberg
mesh_terms: D001569:Benzodiazepines / Q000627:therapeutic use; D003533:Cyproheptadine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D011041:Poisoning / Q000628:therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning*; D000069503:Vilazodone Hydrochloride / Q000506:poisoning*
chemical_list: D001569:Benzodiazepines; D003533:Cyproheptadine; D017367:Selective Serotonin Reuptake Inhibitors; D000069503:Vilazodone Hydrochloride
keywords: drug overdose; pediatric; serotonin syndrome; serotonin uptake inhibitors; toxicology; vilazodone