title: An ecosystem of cancer cell line factories to support a cancer dependency map.
abstract: Jesse Boehm and Todd Golub call for an international effort to establish >10,000 cancer cell line models as a community resource. Cancer cell line factories will facilitate the creation of a cancer dependency map, connecting cancer genomics to therapeutic dependencies.
authors.affiliation: Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.
authors.forename: Jesse S
authors.initials: JS
authors.lastname: Boehm
authors.affiliation: 1] Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA. [2] Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA. [3] Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA. [4] Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 20815, USA.
authors.forename: Todd R
authors.initials: TR
authors.lastname: Golub
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D017753:Ecosystem; D053263:Gene Regulatory Networks; D023281:Genomics / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents