title: Regio-selective deglycosylation of icariin by cell suspension cultures of Glycyrrhiza uralensis and Morus alba.
abstract: Biotransformations of icariin (1) by cell suspension cultures of Glycyrrhiza uralensis and Morus alba yielded two new metabolites, icaruralins A and B (2 and 3), and one known metabolite, baohuoside I (4). Their structures were determined on the basis of extensive spectroscopic analysis. This is the first report that the cell suspension cultures of G. uralensis and M. alba possess deglycosylation functionality.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
authors.forename: De-Wu
authors.initials: DW
authors.lastname: Zhang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tao
authors.forename: Ri-Dao
authors.initials: RD
authors.lastname: Chen
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yu
authors.forename: Jun-Gui
authors.initials: JG
authors.lastname: Dai
mesh_terms: D001711:Biotransformation; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029882:Glycyrrhiza uralensis / Q000737:chemistry*; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
chemical_list: D005419:Flavonoids; C060988:baohuoside I; C056599:icariin
keywords: Glycyrrhiza uralensis; Morus alba; cell suspension cultures; icariin; regio-selective deglycosylation