title: Role of vacuolar-type proton ATPase in signal transduction.
abstract: The vacuolar H(+)-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intra- and extracellular compartments. The acidic pH generated by V-ATPase is important for a wide range of cellular processes as well as acidification-independent processes such as secretion and membrane fusion. In addition to these housekeeping functions, recent studies implicate V-ATPase in the direct regulation and function of signaling pathways. In this review, we describe recent findings on the functions of V-ATPase in growth regulation and tissue physiology.
authors.affiliation: Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kohdo, Kyotanabe, Kyoto 610-0395, Japan. Electronic address: kwada@dwc.doshisha.ac.jp.
authors.forename: Ge-Hong
authors.initials: GH
authors.lastname: Sun-Wada
authors.affiliation: Division of Biological Science, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. Electronic address: yohwada@sanken.osaka-u.ac.jp.
authors.forename: Yoh
authors.initials: Y
authors.lastname: Wada
keywords: Notch; Signaling pathway; V-ATPase; Wnt; mTOR