title: Interleukin-23R rs7517847 T/G Polymorphism Contributes to the Risk of Crohn's Disease in Caucasians: A Meta-Analysis.
abstract: The association between Interleukin-23R gene polymorphism and Crohn's disease (CD) in Caucasians is still controversial. Thus, a meta-analysis was performed to evaluate the correlation between this gene variant and CD risk. We retrieved the available data from EMBASE and PUBMED until May 1, 2014, and evaluated the effect of rs7517847 in Caucasians. The significant associations were confirmed between rs7517847 and CD risk in dominant models (TT/TG versus GG: OR = 1.652, 95% CI 1.277, 2.137), allelic model (T allele versus G allele: OR = 1.327, 95% CI 1.198, 1.469), homozygote comparison (TT versus GG: OR = 1.890, 95% CI 1.465, 2.437), heterozygote comparison (TG versus GG: OR = 1.509, 95% CI 1.161, 1.960), and recessive model (TT versus
  OR = 1.409, 95% CI 1.279, 1.552). In conclusion, this meta-analysis demonstrates that rs7517847 is associated with the risk of CD in Caucasians. These findings show that IL-23R genes confer susceptibility to CD in the Caucasians.
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Li
authors.identifier: 0000-0003-3757-6065
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yunjie
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yuzheng
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Wu
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Li
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.affiliation: Translational Medicine Research Center of Jiangning Hospital and Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Liyang People's Hospital, Liyang 213300, China.
authors.forename: Guozhong
authors.initials: G
authors.lastname: Yao
mesh_terms: D000483:Alleles; D003424:Crohn Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D018123:Receptors, Interleukin