title: Bacterial computing with engineered populations.
abstract: We describe strategies for the construction of bacterial computing platforms by describing a number of results from the recently completed bacterial computing with engineered populations project. In general, the implementation of such systems requires a framework containing various components such as intracellular circuits, single cell input/output and cell-cell interfacing, as well as extensive analysis. In this overview paper, we describe our approach to each of these, and suggest possible areas for future research.
authors.affiliation: School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, Manchester M1 5GD, UK m.amos@mmu.ac.uk.
authors.forename: Martyn
authors.initials: M
authors.lastname: Amos
authors.affiliation: Institut für Synthetische Mikrobiologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
authors.forename: Ilka Maria
authors.initials: IM
authors.lastname: Axmann
authors.affiliation: Institut für Pathologie, Charite-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Blüthgen
authors.affiliation: Intergenomics Group, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, Cantabria, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Cruz
authors.affiliation: School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Jaramillo
authors.affiliation: Laboratorio de Inteligencia Artificial, Universidad Politécnica de Madrid, Madrid 28040, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Rodriguez-Paton
authors.affiliation: Systems Biophysics and Bionanotechnology, Technische Universität München, München, Germany.
authors.forename: Friedrich
authors.initials: F
authors.lastname: Simmel
mesh_terms: D018407:Bacterial Physiological Phenomena; D002450:Cell Communication; D002875:Chromosomes / Q000648:ultrastructure; D003198:Computer Simulation; D003201:Computers; D004926:Escherichia coli / Q000378:metabolism; D005818:Genetic Engineering; D008432:Mathematical Computing; D008954:Models, Biological; D009991:Oscillometry; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D012984:Software; D058615:Synthetic Biology / Q000379:methods*
keywords: conjugation; mathematical modelling; simulation; synthetic biology; unconventional computing