title: Valproic acid hypersensitivity and desensitization.
abstract: Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12-year-old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs. Desensitization is a practical therapeutic solution for patients who develop a non-life-threatening hypersensitivity reaction to an AED for which there may be no substitute.
authors.affiliation: Allergy and Clinical Immunology Service, Shaare Zedek Medical Center, Pediatric Division, Affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Toker
authors.affiliation: Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Center, The Hebrew University, Jerusalem, Israel.
authors.forename: Yuval
authors.initials: Y
authors.lastname: Tal
authors.affiliation: Department of Dermatology, Hadassah Medical Center, The Hebrew University, Jerusalem, Israel.
authors.forename: Liran
authors.initials: L
authors.lastname: Horev
authors.affiliation: Jerusalem District Child Development Center, Clalit Health Services, Jerusalem, Israel.
authors.forename: Dorit
authors.initials: D
authors.lastname: Shmoeli
authors.affiliation: Pediatric Neurology Unit, Pediatric Division, Shaare Zedek Medical Center, Affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel.
authors.forename: Tal
authors.initials: T
authors.lastname: Gilboa
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D004832:Epilepsy, Absence / Q000188:drug therapy*; D005076:Exanthema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid