title: Nanotechnology-Based Drug Delivery Systems for Melanoma Antitumoral Therapy: A Review.
abstract: Melanoma (MEL) is a less common type of skin cancer, but it is more aggressive with a high mortality rate. The World Cancer Research Fund International (GLOBOCAN 2012) estimates that there were 230,000 new cases of MEL in the world in 2012. Conventional MEL treatment includes surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable properties. Drug delivery systems are an alternative strategy by which to carry antineoplastic agents. Encapsulated drugs are advantageous due to such properties as high stability, better bioavailability, controlled drug release, a long blood circulation time, selective organ or tissue distribution, a lower total required dose, and minimal toxic side effects. This review of scientific research supports applying a nanotechnology-based drug delivery system for MEL therapy.
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Roberta Balansin
authors.initials: RB
authors.lastname: Rigon
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Márcia Helena
authors.initials: MH
authors.lastname: Oyafuso
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Andressa Terumi
authors.initials: AT
authors.lastname: Fujimura
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Maíra Lima
authors.identifier: 0000-0003-1090-3062
authors.initials: ML
authors.lastname: Gonçalez
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Alice Haddad
authors.initials: AH
authors.lastname: do Prado
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Maria Palmira Daflon
authors.initials: MP
authors.lastname: Gremião
authors.affiliation: School of Pharmaceutical Sciences, Department of Drug and Medicines, São Paulo State University, 14801-902 Araraquara, SP, Brazil.
authors.forename: Marlus
authors.identifier: 0000-0002-6698-0545
authors.initials: M
authors.lastname: Chorilli
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology
chemical_list: D000970:Antineoplastic Agents