title: Metal Free Formation of Various 3-Iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [1,2-b]Pyridazines and Their Further Functionalization.
abstract: 3-iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [1,2-b]pyridazines were prepared following Groebke-Blackburn-Bienaymé MCR combined with I2-promoted electrophilic cyclization. The flexibility of the method enables the introduction of diversity in the 2, 5, 6, and 7 positions on the resulting scaffold using commercially available starting materials. Furthermore, subsequent palladium-catalyzed reactions were successfully achieved using our iodinated derivatives.
authors.affiliation: †Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans Cedex 2, France.|‡Laboratoire de Chimie Physique et Chimie Organique URAC 22, Faculté des Sciences et Techniques Université Hassan II-Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco.
authors.forename: Z
authors.initials: Z
authors.lastname: Tber
authors.affiliation: †Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: M-A
authors.initials: MA
authors.lastname: Hiebel
authors.affiliation: ‡Laboratoire de Chimie Physique et Chimie Organique URAC 22, Faculté des Sciences et Techniques Université Hassan II-Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco.
authors.forename: A
authors.initials: A
authors.lastname: El Hakmaoui
authors.affiliation: ‡Laboratoire de Chimie Physique et Chimie Organique URAC 22, Faculté des Sciences et Techniques Université Hassan II-Mohammedia-Casablanca, BP 146, 28800 Mohammedia, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Akssira
authors.affiliation: †Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
authors.affiliation: †Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: S
authors.initials: S
authors.lastname: Berteina-Raboin
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008670:Metals; D011724:Pyridazines; D011725:Pyridines; D010165:Palladium; D007455:Iodine