title: The effects of Nano titanium dioxide (TiO2NPs) on lung tissue.
abstract: OBJECTIVE
  The application of nanoparticles is widely spread in all aspects of modern life because of their unique features such as small size and high surface area. High surface area can be very reactive and produce reactive oxygen species (ROS). These nanoparticles can damage human and animal cells by increasing oxidative stress mechanism. Titanium dioxide nanoparticles (TiO2NPs) are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations.TiO2 NPs have various capabilities such as robust oxidation, biocompatibility and photocatalytic properties. They are frequently used in a wide range of sciences, including pharmaceuticals, cosmetics, medicine and engineering. The ever increasing industrial and consumer applications of TiO2NPs raise concern over the possible risk association with their environmental exposure.
  
  
  METHODS
  This study investigates the effects of TiO2NP on lung tissue by intraperitoneal injection to rats at different doses (15, 30, 60 and 70 mg/kg).
  
  
  RESULTS
  Our results showed that intraperitoneal injection of TiO2NP creates capillary congestion and hemorrhage in alveolar wall, granulomas in lung parenchyma, and hemosiderin depositions in blood vessels adjacent to bronchioles without any inflammation. The pulmonary side effects could be due to the production of ROS post TiO2NP exposure (Tab. 1, Fig. 5, Ref. 27). Text in PDF www.elis.sk.
authors.forename: F
authors.initials: F
authors.lastname: Mohammadi
authors.forename: L
authors.initials: L
authors.lastname: Sadeghi
authors.forename: A
authors.initials: A
authors.lastname: Mohammadi
authors.forename: F
authors.initials: F
authors.lastname: Tanwir
authors.forename: V
authors.initials: V
authors.lastname: Yousefi Babadi
authors.forename: M
authors.initials: M
authors.lastname: Izadnejad
mesh_terms: D000818:Animals; D002196:Capillaries / Q000187:drug effects* / Q000473:pathology; D004781:Environmental Exposure; D006099:Granuloma / Q000139:chemically induced / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D007274:Injections, Intraperitoneal; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced; D053768:Metal Nanoparticles / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species; D014025:Titanium / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D017382:Reactive Oxygen Species; C009495:titanium dioxide; D014025:Titanium
keywords: alveolar wall; inflammation.; lung tissue; reactive oxygen species; titanium dioxide nanoparticle