title: Triggering Mechanisms of Thermosensitive Nanoparticles Under Hyperthermia Condition.
abstract: Nanoparticle-based hyperthermia is an effective therapeutic approach that allows time- and site-specific treatment with minimized off-site effects. The recent advances in materials science have led to design a diversity of thermosensitive nanostructures that exhibit different mechanisms of thermal response to the external stimuli. This article aims to provide an extensive review of the various triggering mechanisms in the nanostructures used as adjuvants to hyperthermia modalities. Understanding the differences between various mechanisms of thermal response in these nanostructures could help researchers in the selection of appropriate materials for each experimental and clinical condition as well as to address the current shortcomings of these mechanisms with improved material design.
authors.affiliation: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Ali
authors.initials: A
authors.lastname: Dabbagh
authors.affiliation: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Basri Johan Jeet
authors.initials: BJ
authors.lastname: Abdullah
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Hadijah
authors.initials: H
authors.lastname: Abdullah
authors.affiliation: Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Mohd
authors.initials: M
authors.lastname: Hamdi
authors.affiliation: Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors.forename: Noor Hayaty Abu
authors.initials: NH
authors.lastname: Kasim
mesh_terms: D055598:Chemical Phenomena; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000639:trends; D005782:Gels; D006358:Hot Temperature; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes; D060328:Magnetic Phenomena; D055595:Mechanical Phenomena; D053768:Metal Nanoparticles / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D044367:Phase Transition; D013499:Surface Properties
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D008081:Liposomes; D008823:Micelles
keywords: controlled release/delivery; drug design; nanoparticles; synthesis; targeted drug delivery