title: The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells.
abstract: Physical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps to regulate a whole-body state of metabolism. Under these conditions, the hydrolysis of triacylglycerol (TG) that is found in white adipocytes is known to be augmented via the activation of these lipolytic events, which is referred to as the "lipolytic cascade." Indeed, evidence has shown that the lipolytic responses in white adipocytes are upregulated by continuous exercise training (ET) through the adaptive changes in molecules that constitute the lipolytic cascade. During the past few decades, many lipolysis-related molecules have been identified. Of note, the discovery of a new lipase, known as adipose triglyceride lipase, has redefined the existing concepts of the hormone-sensitive lipase-dependent hydrolysis of TG in white adipocytes. This review outlines the alterations in the lipolytic molecules of white adipocytes that result from ET, which includes the molecular regulation of TG lipases through the lipolytic cascade.
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Junetsu
authors.initials: J
authors.lastname: Ogasawara
authors.affiliation: Graduate School of Health and Sports Science, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.
authors.forename: Tetsuya
authors.identifier: 0000-0001-5197-9085
authors.initials: T
authors.lastname: Izawa
authors.affiliation: Faculty of Culture and Sport Policy, Toin University of Yokohama, Yokohama, Kanagawa 225-8503, Japan.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakurai
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Ken
authors.identifier: 0000-0002-3151-9417
authors.initials: K
authors.lastname: Shirato
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Ishibashi
authors.affiliation: Department of Third Internal Medicine, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishida
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, Japan.
authors.forename: Takako
authors.identifier: 0000-0001-9222-8771
authors.initials: T
authors.lastname: Kizaki
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D052438:Adipocytes, White / Q000378:metabolism*; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008066:Lipolysis / Q000235:genetics*; D009765:Obesity / Q000235:genetics / Q000517:prevention & control*; D010766:Phosphorylation; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides