title: Acute Amiodarone Pulmonary Toxicity after Drug Holiday: A Case Report and Review of the Literature.
abstract: Amiodarone is reported to cause a wide continuum of serious clinical effects. It is often challenging to detect Amiodarone-induced pulmonary toxicity (AIPT). Typically, the diagnosis is made based on the clinical settings and may be supported by histopathology results, if available. We describe a 57-year-old patient who developed severe rapidly progressive respiratory failure secondary to AIPT with acute bilateral infiltrates and nodular opacities on chest imaging. Interestingly, Amiodarone was discontinued 3 weeks prior to his presentation. He had normal cardiac filling pressures confirmed by echocardiography. To our knowledge, this is the first case of isolated acute lung injury induced by Amiodarone, three weeks after therapy cessation, with adequate clinical improvement after supportive management and high dose steroid therapy.
authors.affiliation: Department of Internal Medicine, Creighton University, Omaha, NE 68131, USA.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abuzaid
authors.affiliation: Department of Internal Medicine, Seton Hall University School of Health and Medical Sciences, Trinitas Regional Medical Center, Elizabeth, NJ 07207, USA ; Department of Cardiology, Ain Shams University, Cairo 11381, Egypt.
authors.forename: Marwan
authors.initials: M
authors.lastname: Saad
authors.affiliation: Department of Internal Medicine, Creighton University, Omaha, NE 68131, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ayan
authors.affiliation: Department of Internal Medicine, Creighton University, Omaha, NE 68131, USA.
authors.forename: Amjad
authors.initials: A
authors.lastname: Kabach
authors.affiliation: Department of Internal Medicine, Creighton University, Omaha, NE 68131, USA.
authors.forename: Toufik Mahfood
authors.initials: TM
authors.lastname: Haddad
authors.affiliation: Department of Cardiology, Creighton University, Omaha, NE 68131, USA.
authors.forename: Aiman
authors.initials: A
authors.lastname: Smer
authors.affiliation: Department of Cardiology, Creighton University, Omaha, NE 68131, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Arouni