title: Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution.
abstract: A toluene-soluble molybdenum(vi) complex containing a bulky hydrophobic substituent, (Et4N)2[Mo(VI)O2{1,2-S2-3,6-(RCONH)2C6H2}2] (R = (4-(t)BuC6H4)3C), was dissolved in the hydrophobic core of a micelle in an aqueous medium and catalyzed the biomimetic reduction of an amine N-oxide by an NADH analog. The kinetic isotope effect of solvent water clearly indicates that water molecules are essential for catalysis and are involved in the rate-determining step.
authors.affiliation: Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan. tokamura@chem.sci.osaka-u.ac.jp.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hasenaka
authors.forename: Taka-aki
authors.initials: TA
authors.lastname: Okamura
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Onitsuka
mesh_terms: D032701:Biomimetics; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D008956:Models, Chemical; D008982:Molybdenum / Q000737:chemistry*; D009243:NAD / Q000031:analogs & derivatives / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: C445701:1-benzyl-1,4-dihydronicotinamide; D056831:Coordination Complexes; D008823:Micelles; D012996:Solutions; D014867:Water; D009243:NAD; D008982:Molybdenum