title: Levothyroxine Augmentation in Clozapine Resistant Schizophrenia: A Case Report and Review.
abstract: There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine refractory paranoid schizophrenia and normal thyroid function who added levothyroxine to clozapine and found that symptoms of psychosis returned once levothyroxine was discontinued. Although this observation needs to be confirmed in controlled clinical trials, we aimed to discuss possible hypothesized mechanisms underlying this observation.
authors.affiliation: Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Ruohollah
authors.initials: R
authors.lastname: Seddigh
authors.affiliation: Shahid Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Somayeh
authors.initials: S
authors.lastname: Azarnik
authors.affiliation: Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Amir-Abbas
authors.identifier: 0000-0002-7503-7153
authors.initials: AA
authors.lastname: Keshavarz-Akhlaghi