title: Yes-associated protein in the liver: Regulation of hepatic development, repair, cell fate determination and tumorigenesis.
abstract: The liver is a vital organ that plays a major role in many bodily functions from protein production and blood clotting to cholesterol, glucose and iron metabolism and nutrition storage. Maintenance of liver homeostasis is critical for these essential bodily functions and disruption of liver homeostasis causes various kinds of liver diseases, some of which have high mortality rate. Recent research advances of the Hippo signalling pathway have revealed its nuclear effector, Yes-associated protein, as an important regulator of liver development, repair, cell fate determination and tumorigenesis. Therefore, a precise control of Yes-associated protein activity is critical for the maintenance of liver homeostasis. This review is going to summarize the discoveries on how the manipulation of Yes-associated protein activity affects liver homeostasis and induces liver diseases and the regulatory mechanisms that determine the Yes-associated protein activity in the liver. Finally, we will discuss the potential of targeting Yes-associated protein as therapeutic strategies in liver diseases.
authors.affiliation: Research, Central Texas Veterans Health Care System, Temple, TX, United States.
authors.forename: Quy
authors.initials: Q
authors.lastname: Nguyen
authors.affiliation: Department of Pathology, Johns Hopkins University, Baltimore, MD, United States.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Anders
authors.affiliation: Research, Central Texas Veterans Health Care System, Temple, TX, United States; Digestive Diseases Research Center, BaylorScott&White Healthcare, Temple, TX, United States; Department of Internal Medicine and Medical Physiology, Texas A&M Health Science Center, Temple, TX, United States.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Alpini
authors.affiliation: Research, Central Texas Veterans Health Care System, Temple, TX, United States; Digestive Diseases Research Center, BaylorScott&White Healthcare, Temple, TX, United States; Department of Internal Medicine and Medical Physiology, Texas A&M Health Science Center, Temple, TX, United States. Electronic address: hbai@sw.org.
authors.forename: Haibo
authors.initials: H
authors.lastname: Bai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000502:physiology*; D008113:Liver Neoplasms / Q000378:metabolism*; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics*; D051381:Rats; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D010750:Phosphoproteins; D014157:Transcription Factors; D000091102:YAP-Signaling Proteins; C088374:YAP1 protein, human
keywords: Hippo signalling pathway; Liver; YAP