title: Treatment of Bullous Systemic Lupus Erythematosus.
abstract: Bullous systemic lupus erythematosus (BSLE) is an autoantibody-mediated vesiculobullous disease in patients with SLE. Autoimmunity in BSLE is characterized by the presence of circulating anti-type VII collagen antibodies. BSLE patients often present with multiple, tense, clear fluid-filled vesicles and bullae overlying erythematous edematous plaques. Skin biopsy from BSLE patients shows subepidermal bullae with numerous neutrophils and only occasional eosinophils. Furthermore, immunofluorescence examination showed linear deposition of lgG, lgA, C3, and C1q along the basement membrane zone. BSLE patients with corticosteroids treatment constantly do not receive a marked improvement, while dapsone generally dramatically improved the skin condition. Recently, it has been reported that quite a few cases of BSLE were successfully treated with other immune suppressive drugs. Therefore, a comprehensive review of the treatment of BSLE would be beneficial to cure the disease.
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Lihua
authors.identifier: 0000-0002-1631-4675
authors.initials: L
authors.lastname: Duan
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Liying
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Pathology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Immunology, College of Medicine, Xiamen University, Xiamen 361102, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Rheumatology and Clinical Immunology, The First Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Guixiu
authors.initials: G
authors.lastname: Shi
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents