title: Role of chemotherapy in the treatment of metastatic castration-resistant prostate cancer patients who have progressed after abiraterone acetate.
abstract: Abiraterone acetate is a novel irreversible inhibitor of CYP17 that was recently approved for men with post-chemotherapy or chemo-naive castration-resistant prostate cancer. Unfortunately, this agent is not curative, and patients often ultimately develop resistance. However, men who progress after treatment with this new hormonal agent may be considered for another line of chemotherapy-based treatment. In 2004, docetaxel (D) and prednisone were found to improve survival compared with older regimens. More recently, cabazitaxel (C), a novel taxane chemotherapy, has been found to prolong survival in patients who exhibit disease progression during or after D chemotherapy. Here, we review the first clinical studies in which castration-resistant prostate cancer patients received chemotherapy with D or C after progression during abiraterone acetate treatment.
authors.affiliation: Medical Oncology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 11, 53100, Siena, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Petrioli
authors.forename: Edoardo
authors.initials: E
authors.lastname: Francini
authors.forename: Letizia
authors.initials: L
authors.lastname: Laera
authors.forename: Anna Ida
authors.initials: AI
authors.lastname: Fiaschi
authors.forename: Roberto
authors.initials: R
authors.lastname: Ponchietti
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Roviello
mesh_terms: D000069501:Abiraterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D065607:Cytochrome P-450 Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000077143:Docetaxel; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D043823:Taxoids / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D043823:Taxoids; D000077143:Docetaxel; C552428:cabazitaxel; D000069501:Abiraterone Acetate