title: Fabrication and characterization of electrospun zein/Ag nanocomposite mats for wound dressing applications.
abstract: Wound dressing is a very important factor in the process of wound healing as proper wound care can accelerate the recovery of the wound. In this study, zein nanofibrous mats with fiber diameters around 350-500 nm were prepared by electrospinning and silver (Ag) nanoparticles around 20 nm were concurrently synthesized in situ into the mats. The electrospun nanofibers were characterized by Field Emission-Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analysis. Cell viability and activity of fibroblasts cells in zein/Ag mats were also evaluated and results demonstrated good cytocompatibility and attachment of cells on the composite nanofibers. Also, the bactericidal activity of the fabricated mats against gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) was investigated via zone of inhibition test and results showed high anti-bacterial performance.
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.
authors.forename: Uyanga
authors.initials: U
authors.lastname: Dashdorj
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.
authors.forename: Mark Kenneth
authors.initials: MK
authors.lastname: Reyes
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.
authors.forename: Afeesh Rajan
authors.initials: AR
authors.lastname: Unnithan
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea.
authors.forename: Arjun Prasad
authors.initials: AP
authors.lastname: Tiwari
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea; Power Engineering School, Mongolian University of Science and Technology, Ulaanbaatar, Mongolia.
authors.forename: Batgerel
authors.initials: B
authors.lastname: Tumurbaatar
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea. Electronic address: biochan@jbnu.ac.kr.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Bionanosystem Engineering, Graduate School, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea; Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival; D052978:Disk Diffusion Antimicrobial Tests; D055664:Electrochemical Techniques; D004926:Escherichia coli / Q000187:drug effects; D005347:Fibroblasts / Q000502:physiology; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D009779:Occlusive Dressings; D012835:Silver Nitrate / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013718:Tensile Strength; D015028:Zein / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015028:Zein; D012835:Silver Nitrate
keywords: Electrospinning; Nanofibers; Silver; Wound dressing; Zein