title: Modified quaternary ammonium salts as potential antimalarial agents.
abstract: A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.
authors.affiliation: Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università di Milano, Via Pascal 36, 20133 Milano, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Basilico
authors.affiliation: Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica 'A.Marchesini', Università di Milano, Via Venezian 21, 20133 Milano, Italy.
authors.forename: Mara
authors.initials: M
authors.lastname: Migotto
authors.affiliation: Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Via Pascal 36, 20133 Milano, Italy.
authors.forename: Denise Patoinewende
authors.initials: DP
authors.lastname: Ilboudo
authors.affiliation: Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Via Pascal 36, 20133 Milano, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Taramelli
authors.affiliation: Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica 'A.Marchesini', Università di Milano, Via Venezian 21, 20133 Milano, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Stradi
authors.affiliation: Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica 'A.Marchesini', Università di Milano, Via Venezian 21, 20133 Milano, Italy. Electronic address: elena.pini@unimi.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Pini
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012492:Salts
chemical_list: D000962:Antimalarials; D000644:Quaternary Ammonium Compounds; D012492:Salts
keywords: (2E,4E,6E)-Octatrien-1-ol; Antimalarial drugs; Malaria; P. falciparum; Quaternary ammonium salts