title: Dipeptide-Derived Multifunctional Quaternary Phosphonium Salt Catalyzed Asymmetric Cyclizations via a Tandem Michael Addition/SN 2 Sequence.
abstract: A novel family of dipeptide-based multifunctional quaternary phosphonium salts has been developed as chiral phase-transfer catalysts, which feature ready accessibility and structure modularity, allowing easy fine-tunings of activity. They demonstrated high efficiency in catalyzing the tandem asymmetric Michael addition/intramolecular SN 2 reaction between 6 or 7-substituted conjugate enones and malonates, providing synthetically important five or six-membered carbocycles and heterocycles in good yields and with good to excellent enantioselectivities.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China).
authors.forename: Dongdong
authors.initials: D
authors.lastname: Cao
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China).
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China).
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P. R. China). zhaog@mail.sioc.ac.cn.|Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China). zhaog@mail.sioc.ac.cn.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
keywords: Michael addition; asymmetric cyclizations; dipeptides; organocatalysis; quaternary phosphoniums