title: Cardiac toxoplasmosis after heart transplantation diagnosed by endomyocardial biopsy.
abstract: We describe a case of cardiac toxoplasmosis diagnosed by routine endomyocardial biopsy in a patient with trimethoprim-sulfamethoxazole (TMP-SMX) intolerance on atovaquone prophylaxis. Data are not available on the efficacy of atovaquone as Toxoplasma gondii prophylaxis after heart transplantation. In heart transplant patients in whom TMP-SMX is not an option, other strategies may be considered, including the addition of pyrimethamine to atovaquone.
authors.affiliation: Section of Infectious Disease, University of Chicago, Chicago, Illinois, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Petty
authors.affiliation: Section of Cardiology, University of Chicago, Chicago, Illinois, USA.
authors.forename: S
authors.initials: S
authors.lastname: Qamar
authors.affiliation: Department of Pathology, University of Chicago, Chicago, Illinois, USA.
authors.forename: V
authors.initials: V
authors.lastname: Ananthanarayanan
authors.affiliation: Department of Pathology, University of Chicago, Chicago, Illinois, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Husain
authors.affiliation: Section of Cardiology, University of Chicago, Chicago, Illinois, USA.
authors.forename: C
authors.initials: C
authors.lastname: Murks
authors.affiliation: Department of Pharmacy, University of Chicago, Chicago, Illinois, USA.
authors.forename: L
authors.initials: L
authors.lastname: Potter
authors.affiliation: Section of Cardiology, University of Chicago, Chicago, Illinois, USA.
authors.forename: G
authors.initials: G
authors.lastname: Kim
authors.affiliation: Section of Infectious Disease, University of Chicago, Chicago, Illinois, USA.
authors.forename: K
authors.initials: K
authors.lastname: Pursell
authors.affiliation: Section of Cardiology, University of Chicago, Chicago, Illinois, USA.
authors.forename: S
authors.initials: S
authors.lastname: Fedson
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D053626:Atovaquone / Q000627:therapeutic use; D001706:Biopsy; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology* / Q000517:prevention & control; D014123:Toxoplasmosis / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control
chemical_list: D000890:Anti-Infective Agents; D053626:Atovaquone
keywords: Toxoplasma gondii; diagnosis; endomyocardial biopsy; heart transplantation; prophylaxis; toxoplasmosis