title: Four new phenolic acid with unusual bicycle [2.2.2] octane moiety from Clerodendranthus spicatus and their anti-inflammatory activity.
abstract: Four new phenolic acids, clerodens A-D (1-4) possessing an unusual bicycle [2.2.2] octane moiety were isolated from the whole plants of Clerodendranthus spicatus. Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD data. All isolates were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 4 showed significant inhibitory activities with IC50 value of 6.8 μM.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Guo-Xu
authors.initials: GX
authors.lastname: Ma
authors.affiliation: School of Pharmaceutical Science, Hainan Medical University, Haikou 571101, China.
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Li
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Zhong-Hao
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Nai-Liang
authors.initials: NL
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Yin-Di
authors.initials: YD
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
authors.affiliation: Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China. Electronic address: chendeli9999@163.com.
authors.forename: De-Li
authors.initials: DL
authors.lastname: Chen
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China. Electronic address: hfwu@implad.ac.cn.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D009795:Octanes / Q000737:chemistry* / Q000302:isolation & purification; D000067996:RAW 264.7 Cells
chemical_list: D000893:Anti-Inflammatory Agents; D062385:Hydroxybenzoates; D009795:Octanes; D009569:Nitric Oxide; C017616:phenolic acid
keywords: Anti-inflammatory; Clerodendranthus spicatus; Phenolic acids