title: Do myocardial PET-MR and PET-CT FDG images provide comparable information?
abstract: Although positron emission tomography PET-MR imaging is emerging into clinical practice, many aspects of this imaging technique such as attenuation correction have yet to be validated for myocardial imaging. Thus, it is uncertain whether PET-MR FDG images provide clinical information which is comparable to PET-CT FDG images. The study goal was to systematically compare relative myocardial FDG concentrations obtained from cardiac PET-MR images to those derived from same day PET-CT images.
  
  
  
  Myocardial FDG images of 27 patients undergoing PET-CT imaging, followed by PET-MR imaging 42 ± 13 minutes later as part of a prospective oncology study were analyzed. Mean segmental standardized uptake measurements (SUVmean) were obtained in each of the 17 standard myocardial segments and normalized to the brightest segment.
  
  
  
  Normalized segmental SUVmean values did not differ significantly between the PET-MR and PET-CT images (mean difference 0.002, P = .826). The specific segment was a marginally significant predictor of the differences (P = .057), with the largest difference in the anteroseptal basal segment.
  
  
  
  PET-MR, vis-à-vis PET-CT, does not significantly raise segmental uptake relative to the brightest segment, suggesting that PET-MR can be used similarly to PET-CT for applications where relative uptake is important.
authors.affiliation: Department of Cardiovascular Imaging, Cleveland Clinic Foundation, 9500 Euclid Ave.-J14, Cleveland, OH, 44195, USA. Joldan9@gmail.com.
authors.forename: Jorge D
authors.initials: JD
authors.lastname: Oldan
authors.affiliation: Departments of Radiology and Nuclear Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Shetal N
authors.initials: SN
authors.lastname: Shah
authors.affiliation: Department of Nuclear Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Brunken
authors.affiliation: Department of Nuclear Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Frank P
authors.initials: FP
authors.lastname: DiFilippo
authors.affiliation: Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Obuchowski
authors.affiliation: Department of Cardiovascular Imaging, Cleveland Clinic Foundation, 9500 Euclid Ave.-J14, Cleveland, OH, 44195, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bolen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D057791:Cardiac Imaging Techniques / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Attenuation and scatter correction; PET/CT imaging; image quality; instrumentation: PET; radionuclides