title: Activation-Enabled Syntheses of Functionalized Pillar[5]arene Derivatives.
abstract: A series of regioselective di- and trifunctionalized pillar[5]arene derivatives have been synthesized by a deprotection-followed-by-activation strategy, and their constitutions have been established as a result of having access to their solid-state structures. De-O-methylation occurs in a stepwise manner at lower temperatures under kinetic control, affording the desired oligo-substituted pillar[5]arene derivatives. In addition, the regioisomers of these derivatives can be isolated by installing triflate groups on the free hydroxyl groups.
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.|‡College of Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Han
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Xisen
authors.initials: X
authors.lastname: Hou
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Chenfeng
authors.initials: C
authors.lastname: Ke
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Huacheng
authors.initials: H
authors.lastname: Zhang
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Nathan L
authors.initials: NL
authors.lastname: Strutt
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Stern
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart