title: Dual-controlled release system of drugs for bone regeneration.
abstract: Controlled release systems have been noted to allow drugs to enhance their ability for bone regeneration. To this end, various biomaterials have been used as the release carriers of drugs, such as low-molecular-weight drugs, growth factors, and others. The drugs are released from the release carriers in a controlled fashion to maintain their actions for a long time period. Most research has been focused on the controlled release of single drugs to demonstrate the therapeutic feasibility. Controlled release of two combined drugs, so-called dual release systems, are promising and important for tissue regeneration. This is because the tissue regeneration process of bone formation is generally achieved by multiple bioactive molecules, which are produced from cells by other molecules. If two types of bioactive molecules, (i.e., drugs), are supplied in an appropriate fashion, the regeneration process of living bodies will be efficiently promoted. This review focuses on the bone regeneration induced by dual-controlled release of drugs. In this paper, various dual-controlled release systems of drugs aiming at bone regeneration are overviewed explaining the type of drugs and their release materials.
authors.affiliation: Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Yang-Hee
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. Electronic address: yasuhiko@frontier.kyoto-u.ac.jp.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2 / Q000096:biosynthesis; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D010012:Osteogenesis / Q000187:drug effects*
chemical_list: D043925:Angiogenesis Inducing Agents; C525718:BMP2 protein, human; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D036341:Intercellular Signaling Peptides and Proteins
keywords: Angiogenesis; Bioactive molecules; Bone regeneration; Dual release; Osteogenesis