title: [Chronic toxicity test of fangyouling by transdermal administration in rabbits].
abstract: OBJECTIVE
  To observe the toxicity of fangyouling after one month' s transdermal administration in rabbits and evaluate its security.
  
  
  METHODS
  Forty rabbits were randomly divided into 4 groups including a control group and low, middle and high dose groups of fangyouling. The rabbits in the control group were administered with sunflower oil, and the other rabbits were administrated dermally with fangyouling of 50,300 and 2,000 mg/kg respectively once a day for 4 weeks. The general condition, the skin irritation reaction, body weight, food consumption, hematology, blood biochemistry, organ coefficients and histopathological changes of all the rabbits were observed.
  
  
  RESULTS
  There was no obvious effect on the general condition in all the rabbits. However, the mild skin irritation was observed in 2 rabbits of the middle dose group and 4 rabbits of the high-dose group. The decreases of body weight and food consumption were noted in the high dose group. No changes were detected of hematology, blood biochemistry or viscera pathological at all dose levels.
  
  
  CONCLUSIONS
  The dose of non-toxic response of fangyouling is 50 mg/kg at this study condition.
authors.forename: Zi-ming
authors.initials: ZM
authors.lastname: Jia
authors.forename: Miao-miao
authors.initials: MM
authors.lastname: Yue
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Zheng
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Zhang
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Tang
mesh_terms: D000279:Administration, Cutaneous; D000825:Animal Structures / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D023421:Models, Animal; D011817:Rabbits; D012552:Schistosomiasis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D012556:Schistosomicides / Q000008:administration & dosage / Q000633:toxicity*; D036401:Toxicity Tests, Chronic
chemical_list: D004365:Drugs, Chinese Herbal; D012556:Schistosomicides