title: Body mass index and ghrelin levels after laparoscopic Nissen fundoplication.
abstract: OBJECTIVE
  The study aims to evaluate the changes between body mass index (BMI) and ghrelin levels after laparoscopic Nissen fundoplication (LNF).
  
  
  METHODS
  Twenty-four consecutive patients with gastroesophageal reflux disease who were scheduled for LNF consented to participate in the study. The participants' age, sex, preoperative (phase 0), postoperative 1st week (phase 1) and postoperative 4th week (phase 2) dysphagia scores, plasma ghrelin levels, and BMI were recorded.
  
  
  RESULTS
  Compared to the preoperative level (phase 0), ghrelin was decreased in both phase 1 and phase 2. A strong correlation in the changes in the ghrelin values and BMI between phase 0 and phase 2 was detected. There was a strong, statistically significant difference in the changes in the BMI values between phase 1 and phase 2.
  
  
  CONCLUSIONS
  Total plication of the fundus impairs its ghrelin-secreting functions for up to 4 weeks and is accompanied by weight loss.
authors.affiliation: Department of Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Yigit
authors.forename: Ali Kagan
authors.initials: AK
authors.lastname: Coskun
authors.forename: Ali
authors.initials: A
authors.lastname: Harlak
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sinan
authors.forename: Aytekin
authors.initials: A
authors.lastname: Unlu
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Emin
authors.initials: E
authors.lastname: Lapsekili
authors.forename: Orhan
authors.initials: O
authors.lastname: Kozak
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D054439:Ghrelin