title: Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS).
abstract: OBJECTIVE
  The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression.
  
  
  METHODS
  Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for Dementia of South Korea (CREDOS) multicenter cohort and divided into two groups: (1) progressed to mild cognitive impairment or Alzheimer's disease or (2) stable without progression. Baseline clinical characteristics were compared between the groups, and the most relevant predictors of progression were assessed. A new modeling scale combining the predictors was developed.
  
  
  RESULTS
  In total, 129 subjects with SMI were analyzed. The follow-up duration was 0.5-4.7 years, and the median time to event was 3.64 years. The progressing group (n = 29) differed from the stable group (n = 100) in terms of baseline age, apolipoprotein E4 (APOE4) status, and some cognitive domains. Older age, a lower Mini-Mental State Examination recall score, APOE4 carrier, and a lower verbal delayed recall score were the most relevant predictors of progression, and a new modeling scale with these 4 predictors provided a better explanation of progression.
  
  
  CONCLUSIONS
  SMI subjects with a higher risk of progression can be identified using a new modeling scale and might need further evaluations and more frequent follow-up.
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: Yun Jeong
authors.initials: YJ
authors.lastname: Hong
authors.forename: Bora
authors.initials: B
authors.lastname: Yoon
authors.forename: Yong S
authors.initials: YS
authors.lastname: Shim
authors.forename: Seon-Ok
authors.initials: SO
authors.lastname: Kim
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Seong Hye
authors.initials: SH
authors.lastname: Choi
authors.forename: Jee Hyang
authors.initials: JH
authors.lastname: Jeong
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Yang
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis; D053327:Apolipoprotein E4 / Q000235:genetics; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis*; D008875:Middle Aged; D009483:Neuropsychological Tests; D056910:Republic of Korea; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4