title: Efficacy and safety of hylan G-F 20 injection in treatment of knee osteoarthritis in Chinese patients: results of a prospective, multicentre, longitudinal study.
abstract: OBJECTIVE
  To study the efficacy and safety of single intra-articular injection of 6-mL hylan G-F 20 in Chinese patients with symptomatic knee osteoarthritis.
  
  
  METHODS
  Prospective case series.
  
  
  METHODS
  Six government hospitals in Hong Kong.
  
  
  METHODS
  Patients with primary knee osteoarthritis were recruited from six government hospitals from 1 October 2010 to 31 May 2012. All patients received 6-mL intra-articular injection of hylan G-F 20.
  
  
  METHODS
  Pain visual analogue scale, functional visual analogue scale, and 5-point Likert scale on change of pain and function were assessed. Adverse events were checked. Radiographs were taken pre-injection and at 3 months and 1 year.
  
  
  RESULTS
  A total of 110 knees of 95 patients with primary knee osteoarthritis were treated. The mean age of the patients was 62 (standard deviation, 9.8) years. All patients completed 1 year of follow-up. The mean pain visual analogue scale, functional visual analogue scale, and Likert value for pain and function showed statistically significant improvements at 6 weeks, 3 months, 6 months, and 1 year compared with the pre-injection values. No significant correlations were found between changes in visual analogue scale and age, body mass index, pre-injection radiological osteoarthritis severity, serum erythrocyte sedimentation rate, or C-reactive protein. Serial radiographs did not show any changes in the radiological severity of knee osteoarthritis. Overall, 16.4% of the patients experienced mild and self-limiting adverse events.
  
  
  CONCLUSIONS
  Hylan G-F 20 is a safe and effective therapy to relieve pain and improve function for up to 1 year in Chinese patients with knee osteoarthritis.
authors.affiliation: Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
authors.forename: C H
authors.initials: CH
authors.lastname: Yan
authors.affiliation: Department of Orthopaedics and Traumatology, Kwong Wah Hospital, Yaumatei, Hong Kong.
authors.forename: W L
authors.initials: WL
authors.lastname: Chan
authors.affiliation: Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Jordan, Hong Kong.
authors.forename: W H
authors.initials: WH
authors.lastname: Yuen
authors.affiliation: Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
authors.forename: Patrick S H
authors.initials: PS
authors.lastname: Yung
authors.affiliation: Department of Orthopaedics and Traumatology, North District Hospital, Sheung Shui, Hong Kong.
authors.forename: K Y
authors.initials: KY
authors.lastname: Ip
authors.affiliation: Department of Orthopaedics and Traumatology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong.
authors.forename: Jason C H
authors.initials: JC
authors.lastname: Fan
authors.affiliation: Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.
authors.forename: K Y
authors.initials: KY
authors.lastname: Chiu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001799:Blood Sedimentation; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D007270:Injections, Intra-Articular; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010147:Pain Measurement; D011446:Prospective Studies; D011859:Radiography; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: C049816:hylan; D006820:Hyaluronic Acid; D002097:C-Reactive Protein
keywords: Hyaluronic acid; Osteoarthritis, knee/therapy; Treatment outcome