title: Genetic polymorphisms in pattern recognition receptors and risk of periodontitis: Evidence based on 12,793 subjects.
abstract: Pattern recognition receptors (PRRs) constitute a pivotal arm of innate immunity. Many studies investigated the association between PRRs polymorphisms and periodontitis risk, which showed inconclusive results. The aim of the meta-analysis was to evaluate the precise association between five widely-evaluated polymorphisms (CD14 -260C/T (rs2569190), Toll-like receptor (TLR) 2 2408G/A (rs5743708), TLR4 896A/G (rs4986790), TLR4 1196C/T (rs4986791), mannose-binding lectin (MBL) codon 54 (rs1800450)) within the PRRs and susceptibility to either chronic (CP) or aggressive periodontitis (AgP). Overall, no significant association was found for the PRRs polymorphisms with either CP or AgP. In the subgroup analyses, TLR4 896G and 1196T alleles yielded a 32% (OR=1.32, 95% CI: 1.04-1.68) and a 37% increased CP risk (OR=1.37, 95% CI: 1.05-1.80) in Caucasians, respectively. Further stratified analyses revealed links between CD14, MBL2 polymorphisms and the severity of CP. This meta-analysis suggested that the periodontitis susceptibility was partly controlled by PRRs polymorphisms involved in the innate immunity.
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: Min-xuan
authors.initials: MX
authors.lastname: Han
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ding
authors.affiliation: Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea. Electronic address: hmkyung@knu.ac.kr.
authors.forename: Hee-Moon
authors.initials: HM
authors.lastname: Kyung
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D037601:Mannose-Binding Lectin / Q000235:genetics; D010518:Periodontitis / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D051192:Receptors, Pattern Recognition / Q000235:genetics*; D012306:Risk; D051197:Toll-Like Receptor 4 / Q000235:genetics
chemical_list: D018950:Lipopolysaccharide Receptors; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D051192:Receptors, Pattern Recognition; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4
keywords: CD14; Gene polymorphisms; Mannose-binding lectin; Periodontitis; Toll-like receptors