title: Role of leptin and leptin receptors in hematological malignancies.
abstract: Leptin is an adipose-derived cytokine that has an important role in bodyweight homeostasis and energy balance. There are a number of studies which have suggested that leptin and its receptors dysregulation play a critical role in the development of malignancies including hematological malignancies, mainly via activation of the JAK/STAT pathway which regulates downstream signaling pathways such as PI3K/AKT signaling and ERK1/2. In this review, current understandings of leptin/leptin receptors mediated pathogenesis in various lymphoid malignancies are described. Blocking of the leptin receptor might be a unique therapeutic approach for many hematological malignancies.
authors.affiliation: a Translational Research Institute, Academic Health System, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Shahab
authors.initials: S
authors.lastname: Uddin
authors.affiliation: a Translational Research Institute, Academic Health System, Hamad Medical Corporation , Doha , Qatar.
authors.forename: Ramzi M
authors.initials: RM
authors.lastname: Mohammad
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011485:Protein Binding; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism*; D012306:Risk; D015398:Signal Transduction
chemical_list: D020738:Leptin; D054411:Receptors, Leptin
keywords: Leptin; Ob-R; PI3-kInase/AKT pathway; leukemia; lymphoma