title: [Hematopoietic stem cell exhaustion and advanced glycation end-products in the unexplained anemia of the elderly].
abstract: BACKGROUND
  More than 10% of the aged 65 years and over in the western world suffers anemia and in one third of them the cause of the anemia remains obscure. The unexplained anemia of the elderly (UAE) is considered an exclusion diagnosis, without the existence of a clear consensus to its clinical or experimental approach. There is an association between aging and anemia in studies performed in animals and in humans.
  
  
  OBJECTIVE
  To determine if there is evidence in the literature that supports hematopoietic stem cells (HSC) exhaustion and the advanced glycation end-products (AGE's) as a cause of UAE.
  
  
  METHODS
  A total of 32 combined texts (28 for HSC exhaustion and 4 for AGEs) were selected after an intensive review. Conclusions were associated with causes and effects of the HSC exhaustion and circulating AGE's over aging and anemia.
  
  
  RESULTS
  Only three works try to establish an association between UAE and HSC exhaustion, two of them disagreed in their conclusions, with the third one differing in the type of study. There is a relationship between anemia and AGEs increase and accumulation.
  
  
  CONCLUSIONS
  There is evidence in the literature that links the aging molecular and cellular mechanisms with the HSC exhaustion and the increase of AGE's. Furthermore; there is some evidence that both conditions determine the emergence of anemia associated with age in animals and in humans. There is little evidence in the literature to clarify the relationship between aging and UAE.
authors.affiliation: Servicio Médico, Residencia Gerontológica Casaverde, Guardamar del Segura, Alicante, España. Electronic address: medico.guardamar@grupocasaverde.com.
authors.forename: Bernard
authors.initials: B
authors.lastname: Sestier
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood*; D017127:Glycation End Products, Advanced / Q000097:blood*; D006412:Hematopoietic Stem Cells; D006801:Humans
chemical_list: D017127:Glycation End Products, Advanced
keywords: Advanced glycation end products; Aging; Anemia; Células madre hematopoyéticas; Envejecimiento; Eritropoyesis; Erythropoiesis; Hematopoietic stem cells; Productos avanzados de la glicación avanzada