title: Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
abstract: Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of cancer death. A complex disease arising from the interaction of environmental and host-associated factors, key contributors to GC's high mortality include its silent nature, late clinical presentation, and underlying biological and genetic heterogeneity. Achieving a detailed molecular understanding of the various genomic aberrations associated with GC will be critical to improving patient outcomes. The recent years has seen considerable progress in deciphering the genomic landscape of GC, identifying new molecular components such as ARID1A and RHOA, cellular pathways, and tissue populations associated with gastric malignancy and progression. The Cancer Genome Atlas (TCGA) project is a landmark in the molecular characterization of GC. Key challenges for the future will involve the translation of these molecular findings to clinical utility, by enabling novel strategies for early GC detection, and precision therapies for individual GC patients.
authors.affiliation: Cancer and Stem Cell Biology Program, Duke-National University of Singapore Graduate Medical School, Singapore; Genome Institute of Singapore, Agency for Science, Technology, and Research, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Cellular and Molecular Research, National Cancer Centre Singapore, Singapore; Singapore Gastric Cancer Consortium, Singapore. Electronic address: gmstanp@duke-nus.edu.sg.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tan
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Gastroenterology and Hepatology, National University Health System, Singapore; Singapore Gastric Cancer Consortium, Singapore. Electronic address: khay_guan_yeoh@nuhs.edu.sg.
authors.forename: Khay-Guan
authors.initials: KG
authors.lastname: Yeoh
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D004268:DNA-Binding Proteins; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods / Q000639:trends; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*; D014157:Transcription Factors / Q000235:genetics; D020742:rhoA GTP-Binding Protein / Q000235:genetics
chemical_list: C112476:ARID1A protein, human; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C066737:RHOA protein, human; D020742:rhoA GTP-Binding Protein
keywords: Cancer Genetics; Cancer Genomics; Gastric Cancer