title: [Reconstruction method of language pathways in the preoperative planning of brain tumor surgery].
abstract: OBJECTIVE
  To propose a clinically practical and simple fiber tracking method for language pathways, and to explore its feasibility in preoperative planning for brain tumors adjacent to the language cortex.
  
  
  METHODS
  Diffusion tensor imaging was examined in 18 healthy subjects and 13 patients with brain tumors adjacent to the language cortex between December 2013 and June 2014. The associated fibers of language pathways were reconstructed using a commercial software (Syngo workstation). Firstly, the feasibility of fiber tracking method for language pathways in healthy subjects were studied, and then its application was assessed in patients with brain tumors. The anatomic relationship between tumors and the associated fibers was analyzed.
  
  
  RESULTS
  By selecting appropriate regions of interest, the associated fibers in the dorsal pathways (superior longitudinal fasciculus/arcuate fasciculus, including both direct and indirect pathways) and ventral pathways (uncinate fasciculus, middle longitudinal fasciculus, inferior longitudinal fasciculus and inferiorfronto-occipital fasciculus) were reconstructed in all 18 healthy subjects. In patients with brain tumors, the relationship between the tumors and adjacent associated fibers were divided into two types: adjacent associated fibers could be displaced or separated, and involved the superior longitudinal fasciculus/arcuate fasciculus (n=6), middle longitudinal fasciculus (n=4), uncinate fasciculus (n=3), inferior longitudinal fasciculus (n=3) and inferiorfronto-occipital fasciculus (n=2); alternatively, the adjacent associated fibers were infiltrated or destroyed, and involved the inferiorfronto-occipital fasciculus (n=10), uncinate fasciculus (n=8), middle longitudinal fasciculus (n=5), inferior longitudinal fasciculus (n=4) and superior longitudinal fasciculus/arcuate fasciculus (n=3).
  
  
  CONCLUSIONS
  The associated fibers of language pathways could be visualized rapidly and in real-time by fiber tracking technology based on diffusion tensor imaging. This is feasible for preoperative planning regarding brain tumors adjacent to the language cortex.
authors.affiliation: Department of MRI, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.forename: Junfeng
authors.initials: J
authors.lastname: Lu
authors.affiliation: Email: cjr.chjl@vip.163.com.
authors.forename: Jingliang
authors.initials: J
authors.lastname: Cheng
authors.forename: Jinsong
authors.initials: J
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Chaoyan
authors.initials: C
authors.lastname: Wang
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Nie
authors.forename: Beibei
authors.initials: B
authors.lastname: Pang
authors.forename: Xianzhi
authors.initials: X
authors.lastname: Liu
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery*; D002540:Cerebral Cortex / Q000601:surgery*; D056324:Diffusion Tensor Imaging; D006801:Humans; D007802:Language; D009434:Neural Pathways; D011183:Postoperative Complications / Q000517:prevention & control