title: Neural population dynamics in human motor cortex during movements in people with ALS.
abstract: The prevailing view of motor cortex holds that motor cortical neural activity represents muscle or movement parameters. However, recent studies in non-human primates have shown that neural activity does not simply represent muscle or movement parameters; instead, its temporal structure is well-described by a dynamical system where activity during movement evolves lawfully from an initial pre-movement state. In this study, we analyze neuronal ensemble activity in motor cortex in two clinical trial participants diagnosed with Amyotrophic Lateral Sclerosis (ALS). We find that activity in human motor cortex has similar dynamical structure to that of non-human primates, indicating that human motor cortex contains a similar underlying dynamical system for movement generation.
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Chethan
authors.identifier: http://orcid.org/0000-0003-1241-1432
authors.initials: C
authors.lastname: Pandarinath
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Vikash
authors.initials: V
authors.lastname: Gilja
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Christine H
authors.initials: CH
authors.lastname: Blabe
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Paul
authors.identifier: http://orcid.org/0000-0001-7778-5473
authors.initials: P
authors.lastname: Nuyujukian
authors.affiliation: School of Engineering, Brown University, Providence, United States.
authors.forename: Anish A
authors.identifier: http://orcid.org/0000-0003-1261-0589
authors.initials: AA
authors.lastname: Sarma
authors.affiliation: Neurology, Massachusetts General Hospital, Boston, United States.
authors.forename: Brittany L
authors.initials: BL
authors.lastname: Sorice
authors.affiliation: Department of Neurosurgery, Harvard Medical School, Boston, United States.
authors.forename: Emad N
authors.initials: EN
authors.lastname: Eskandar
authors.affiliation: Center for Neurorestoration and Neurotechnology, Rehabilitation R and D Service, Department of VA Medical Center, , Providence, United States.
authors.forename: Leigh R
authors.identifier: http://orcid.org/0000-0003-0261-2273
authors.initials: LR
authors.lastname: Hochberg
authors.affiliation: Department of Neurosurgery, Stanford University, Stanford, United States.
authors.forename: Jaimie M
authors.identifier: http://orcid.org/0000-0002-3276-2267
authors.initials: JM
authors.lastname: Henderson
authors.affiliation: Department of Electrical Engineering, Stanford University, Stanford, United States.
authors.forename: Krishna V
authors.identifier: http://orcid.org/0000-0003-1534-9240
authors.initials: KV
authors.lastname: Shenoy
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
keywords: computational neuroscience; dynamical systems; human; human biology; medicine; motor control; motor cortex; neuroscience