title: Expression of androgen receptor in coronary artery in the cases of sudden coronary death.
abstract: To study the expression of androgen receptor (AR) in the cases of sudden death caused by coronary heart disease (CHD) and relationship between AR and sudden coronary death (SCD) to explore the mechanism of the development of coronary atherosclerosis and provide references for the prevent and treatment of CHD and medicolegal identification of SCD. 53 cases selected from the autopsied cases in our department from 2011 to 2012 were divided into 3 groups: 18 case of SCD, including 11 males and 7 females, as experimental group, another 18 cases, including 11 males and 7 females, with CHD but died of mechanical injuries and poisoning as control group I, and 17 cases without CHD who also died of mechanical injuries and poisoning including 10 males and 7 females, as control group II. After HE-stained and immunohistochemistry-stained (SP) for the slices, the expression of AR in coronary arteries were observed and the average optical density (AOD) of positive signal in each case were detected by using Image-Pro Plus 6.0 software. We found strongly positive expression of AR in control group II, weakly positive expression in control group I and a little weaker in the experimental group. The expression of AR in coronary artery was reduced in CHD patients, which suggested that androgen may have favorable effects on the cardiovascular system.
authors.affiliation: Department of Forensic Pathology, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China ; Department of Pathology, Meizhou People's Hospital Meizhou 514031, China.
authors.forename: Kaiyi
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Forensic Pathology, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China ; Department of Molecular Pharmacology and Physiology, University of South Florida Tampa, 33620 FL, USA.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Forensic Pathology, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.
authors.forename: Xinshan
authors.initials: X
authors.lastname: Chen
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism*; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism*; D016757:Death, Sudden, Cardiac; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000378:metabolism*
chemical_list: D011944:Receptors, Androgen
keywords: Androgen receptor; coronary atherosclerosis; immunohistochemistry; sudden coronary death