title: Three infants with rotavirus gastroenteritis complicated by severe gastrointestinal bleeding.
abstract: Rotavirus gastroenteritis causes substantial morbidity and mortality worldwide in children. We report three infants with rotavirus gastroenteritis complicated by various severity of gastrointestinal bleeding. Two patients (cases 1 and 2) recovered completely without any specific treatments. One patient (case 3) died despite extensive treatments including a red blood cell transfusion and endoscopic hemostatic therapy. Rotavirus genotypes G1P[8] and G9P[8] were detected in cases 2 and 3, respectively. Rotavirus antigenemia levels were not high at the onset of melena, suggesting that systemic rotaviral infection does not play an important role in causing melena.
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kawamura
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Miura
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sugata
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Morooka
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Ikuya
authors.initials: I
authors.lastname: Tsuge
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yoshikawa
authors.affiliation: Department of Virology and Parasitology, Fujita Health University School of Medicine, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Taniguchi
authors.affiliation: Department of Pediatrics, Fujita Health University School of Medicine, Japan.
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000956:Antigens, Viral / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D005759:Gastroenteritis / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000473:pathology*; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D012401:Rotavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D014766:Viremia / Q000175:diagnosis
chemical_list: D000956:Antigens, Viral
keywords: antigenemia; duodenal ulcer; gastroenteritis; gastrointestinal bleeding; rotavirus