title: Current concepts in the management of hidradenitis suppurativa in children.
abstract: OBJECTIVE
  This review is intended to provide the background aetiopathogenetic framework upon which management of this disorder can be based, particularly with relation to new concepts of the pathogenesis of the disorder. The emphasis is on the prevention of the disorder's full expression by addressing the metabolic changes that drive the underlying structural damage and the immune system's subsequent reaction to this damage.
  
  
  RESULTS
  The mechanism by which dietary factors impact on this disease are elucidated, the anatomic defect suspected to be responsible for the disorder is introduced, and an updated flow sheet describing and linking the clinicopathological changes recently described are provided.
  
  
  CONCLUSIONS
  Recent work in the understanding of the induction and evolution of the lesions provides a background upon which the preventive regimen and both the medical and surgical approaches can be effectively based.
authors.affiliation: Geisel School of Medicine at Dartmouth, Manchester, NH, USA.
authors.forename: F William
authors.initials: FW
authors.lastname: Danby
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003611:Dairy Products / Q000009:adverse effects*; D017497:Hidradenitis Suppurativa / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D006801:Humans; D056747:Immunomodulation; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D014409:Tumor Necrosis Factor-alpha