title: Efficacy of five commercial disinfectants and one anionic surfactant against equine herpesvirus type 1.
abstract: We investigated the influences of various reaction conditions on equine herpesvirus type 1 (EHV-1) disinfection by 5 commercial disinfectants (3 quaternary ammonium compounds [QACs] and 2 chlorine-based disinfectants) and 1 anionic surfactant. QACs at their highest recommended concentrations had no virucidal effect on EHV-1 with a 10-min reaction time at 0°C or a 1-min reaction time at room temperature. Chlorine-based disinfectants achieved EHV-1 disinfection with a 10-min reaction time at -10°C or a 30-sec reaction time at room temperature. In the presence of 5% fetal bovine serum, QACs (except for benzalkonium chloride) showed more stable virucidal effects than did chlorine-based disinfectants. The virucidal effect of the anionic surfactant was almost equivalent to that of the QACs.
authors.affiliation: Epizootic Research Center, Equine Research Institute, Japan Racing Association,1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tsujimura
authors.forename: Harutaka
authors.initials: H
authors.lastname: Murase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Bannai
authors.forename: Manabu
authors.initials: M
authors.lastname: Nemoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kondo
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002713:Chlorine; D004202:Disinfectants / Q000737:chemistry / Q000494:pharmacology*; D004861:Herpesvirus 1, Equid / Q000187:drug effects*; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D017738:Alkanesulfonic Acids; D004202:Disinfectants; D013501:Surface-Active Agents; C030641:alkylbenzyl sulfonic acid; D002713:Chlorine