title: Neuroplastic Sensorimotor Resting State Network Reorganization in Children With Hemiplegic Cerebral Palsy Treated With Constraint-Induced Movement Therapy.
abstract: Using resting state functional magnetic resonance imaging (MRI), we aim to understand the neurologic basis of improved function in children with hemiplegic cerebral palsy treated with constraint-induced movement therapy. Eleven children including 4 untreated comparison subjects diagnosed with hemiplegic cerebral palsy were recruited from 3 clinical centers. MRI and clinical data were gathered at baseline and 1 month for both groups, and 6 months later for the case group only. After constraint therapy, the sensorimotor resting state network became more bilateral, with balanced contributions from each hemisphere, which was sustained 6 months later. Sensorimotor resting state network reorganization after therapy was correlated with a change in the Quality of Upper Extremity Skills Test score at 1 month (r = 0.79, P = .06), and Canadian Occupational Performance Measure scores at 6 months (r = 0.82, P = .05). This clinically correlated resting state network reorganization provides further evidence of the neuroplastic mechanisms underlying constraint-induced movement therapy.
authors.affiliation: Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
authors.forename: Kathryn Y
authors.initials: KY
authors.lastname: Manning
authors.affiliation: Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Menon
authors.affiliation: CanChild Centre for Childhood Disability Research, McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Jan Willem
authors.initials: JW
authors.lastname: Gorter
authors.affiliation: CanChild Centre for Childhood Disability Research, McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors.forename: Ronit
authors.initials: R
authors.lastname: Mesterman
authors.affiliation: Department of Paediatrics and Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
authors.forename: Craig
authors.initials: C
authors.lastname: Campbell
authors.affiliation: Department of Paediatrics, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
authors.forename: Lauren
authors.initials: L
authors.lastname: Switzer
authors.affiliation: Department of Paediatrics, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada dfehlings@hollandbloorview.ca.
authors.forename: Darcy
authors.initials: D
authors.lastname: Fehlings
mesh_terms: D000293:Adolescent; D001132:Arm / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D002547:Cerebral Palsy / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D002648:Child; D015331:Cohort Studies; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D007839:Functional Laterality; D006429:Hemiplegia / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology*; D012146:Rest; D012149:Restraint, Physical / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: cerebral palsy; constraint-induced movement therapy; neuroplasticity; resting state network