title: Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine.
abstract: Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2Å.
authors.affiliation: Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia. Electronic address: kiselev@nf.jinr.ru.
authors.forename: M A
authors.initials: MA
authors.lastname: Kiselev
authors.affiliation: Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Zemlyanaya
authors.affiliation: V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
authors.affiliation: National Research Center «Kurchatov Institute», Moscow, Russia.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Gruzinov
authors.affiliation: Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Ermakova
authors.affiliation: National Research Center «Kurchatov Institute», Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Zabelin
authors.affiliation: Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; International University "Dubna", Dubna, Moscow Region 141980 Russia.
authors.forename: E I
authors.initials: EI
authors.lastname: Zhabitskaya
authors.affiliation: V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
authors.forename: O S
authors.initials: OS
authors.lastname: Druzhilovskaya
authors.affiliation: Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; Petersburg Nuclear Physics Institute, NRC «Kurchatov Institute», Gatchina, Russia.
authors.forename: V L
authors.initials: VL
authors.lastname: Aksenov
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems; D004655:Emulsions; D008051:Lipid Bilayers / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D012542:Scattering, Radiation; D012997:Solvents; D013025:Glycine max / Q000737:chemistry*; D014965:X-Rays
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008051:Lipid Bilayers; D008823:Micelles; D010713:Phosphatidylcholines; D012997:Solvents
keywords: Drug carriers; Synchrotron; Vesicles; X-ray scattering