title: Relations Between Pathological Markers and Radioiodine Scan and (18)F-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases.
abstract: OBJECTIVE
  The aim of this study was to investigate relationships between the immunohistochemical results and radioiodine scan and (18)F-FDG PET findings in papillary thyroid cancer (PTC) patients with recurrent cervical nodal metastases.
  
  
  METHODS
  A total of 46 PTC patients who had undergone a radioiodine scan and/or (18)F-FDG PET/CT and a subsequent operation on recurrent cervical lymph nodes were enrolled. Twenty-seven patients underwent (18)F-FDG PET/CT, 8 underwent radioiodine scans, and 11 underwent both scans. In all surgical specimens, the immunoexpressions of thyroglobulin (Tg), sodium-iodide symporter (NIS), glucose transporter 1 (Glut-1), and somatostatin receptor 1 and 2A (SSTR1 and SSTR2A) were assessed, and associations between these expressions and radioiodine scan and (18)F-FDG PET findings were evaluated.
  
  
  RESULTS
  Of the 38 patients who underwent (18)F-FDG PET/CT, all patients with weak Tg expression had positive (18)F-FDG uptake, while only 45 % of the patients with moderate or strong Tg expression showed positive uptake (p = 0.01). The proportion of patients with positive (18)F-FDG uptake increased as the degree of Glut-1 expression with luminal accentuation increased. Of the 19 patients who underwent a radioiodine scan, the proportion with positive radioiodine uptake was greater among patients with strong NIS and SSTR2A expression than among patients expressing these markers at weak levels (p = 0.04 for all). All three patients with weak Tg expression were negative for radioiodine uptake.
  
  
  CONCLUSIONS
  The (18)F-FDG uptakes of recurrent cervical nodes are related to strong Glut-1 expression with luminal accentuation and weak Tg expression, whereas radioiodine uptake is related to the strong expressions of NIS and SSTR2A.
authors.affiliation: Department of Nuclear Medicine, Catholic Kwandong University International St. Mary's Hospital, Seoul, Korea.
authors.forename: Jeong Won
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Pathology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Min
authors.affiliation: Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors.forename: Sang Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Medicine, 101 Daehang-Ro, Jongno-Gu, Seoul, 110-744 Korea.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kwon
authors.affiliation: Department of Nuclear Medicine, Seoul National University College of Medicine, Medicine, 101 Daehang-Ro, Jongno-Gu, Seoul, 110-744 Korea ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: June-Key
authors.initials: JK
authors.lastname: Chung
keywords: 18F-fluorodeoxyglucose; Positron emission tomography; Radioiodine; Thyroid cancer