title: A population association study of PPAR δ gene rs2016520 and rs9794 polymorphisms and haplotypes with body mass index and waist circumference in a Chinese population.
abstract: BACKGROUND
  Peroxisome proliferator-activated receptor (PPAR) gene plays an important role in obesity and PPAR δ protein is a potent inhibitor; however, few previous studies have focused on this gene.
  
  
  OBJECTIVE
  To investigate the association of haplotypes of PPAR δ gene rs2016520 and rs9794 with abnormal weight (BMI ≥ 24 kg/m(2)) and abdominal obesity (WC ≥ 90 cm for males and ≥ 80 cm for females) in a Chinese Han population.
  
  
  METHODS
  In total, 820 subjects (270 men, 550 women) were randomly selected from the PMMJS cohort population and no individuals were related. rs2016520 and rs9794 were detected by TaqMan fluorescence probe. Hardy-Weinberg equilibrium (HWE) was used to detect genotype typing errors by Fisher's exact test. Linkage disequilibrium (LD) between polymorphisms was estimated by using SHEsis. Two PPAR δ SNPs (rs2016520 and rs9794) were analysed by using the logistic regression model.
  
  
  RESULTS
  After adjustment for covariates, the haplotype containing the rs1026520-C and rs9794-C alleles was associated with a statistically significant decreased risk of obesity (OR = 0.64; 95% CI = 0.48-0.84, p = 0.0015). Coincidentally, the haplotype containing the rs1026520-C and rs9794-C alleles was also associated with a statistically decreased risk of abdominal obesity after covariate adjustment (OR = 0.59, 95% CI = 0.45-0.77, p < 0.001).
  
  
  CONCLUSIONS
  C-C haplotype, constructed from rs2016520 and rs9794 alleles, showed a significant protective effect for both abnormal weight and abdominal obesity.
authors.affiliation: a Changzhou Center for Disease Control and Prevention , Changzhou , Jiangsu , PR China .|b Suzhou Health College , Suzhou , Jiangsu , PR China .
authors.forename: Wenshu
authors.initials: W
authors.lastname: Luo
authors.affiliation: b Suzhou Health College , Suzhou , Jiangsu , PR China .
authors.forename: Fengmei
authors.initials: F
authors.lastname: Chen
authors.affiliation: c Department of Public Health , Soochow University , Suzhou , Jiangsu , PR China .
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: d Center for Disease Control of Jiangsu Province , Nanjing , Jiangsu , PR China , and.
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.affiliation: e Center for Disease Control of Changshu , Suzhou , Jiangsu , PR China.
authors.forename: Zhengyuan
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: a Changzhou Center for Disease Control and Prevention , Changzhou , Jiangsu , PR China .
authors.forename: Xingjuan
authors.initials: X
authors.lastname: Yao
mesh_terms: D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight; D002681:China / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D056128:Obesity, Abdominal / Q000235:genetics*; D047494:PPAR delta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D012044:Regression Analysis; D017422:Sequence Analysis, DNA; D055105:Waist Circumference
chemical_list: D047494:PPAR delta
keywords: BMI; haplotype; peroxisome proliferator-activated receptors δ; polymorphisms; waist circumference