title: Prepubertal exposure to bisphenol-A induces ERα upregulation and hyperplasia in adult gerbil female prostate.
abstract: Prostate physiology is highly dependent on oestrogenic and androgenic homeostasis. Interferences in this equilibrium, especially in early periods of life, may disrupt the prostate and increase the susceptibility to the development of diseases with ageing. Taking this into account, and considering the increase of environmental chemicals with endocrine-disrupting potential such as bisphenol-A (BPA), this study aimed to evaluate the prostates of adult female gerbils exposed to BPA and BPA plus testosterone from pubertal to adult periods. Morphological, stereological and chemical analyses revealed that long-term BPA exposure, even in environmental dosages, increases the proliferative status of the prostate, increases the number of ERα-positive stromal cells and elicits the development of prostatic hyperplasia in adult female gerbils. Moreover, we also observed that the association with testosterone did not increase the proliferative status of the gland, which shows that low levels of BPA are enough to cause an oestrogenic disruption of the prostate in young adults. This evidence suggests that this oestrogenic endocrine disruptor may increase the susceptibility to prostatic disorders with ageing.
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, University Estadual Paulista - UNESP, São José do Rio Preto, Brazil.
authors.forename: Mônica S
authors.initials: MS
authors.lastname: Campos
authors.affiliation: Department of Histology, Embriology and Cell Biology, Federal University of Goiás, Goiânia, Brazil.
authors.forename: André L V
authors.initials: AL
authors.lastname: Galvão
authors.affiliation: Department of Histology, Embriology and Cell Biology, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Daniel A O
authors.initials: DA
authors.lastname: Rodríguez
authors.affiliation: Department of Structural and Functional Biology, State University of Campinas, Campinas, Brazil.
authors.forename: Manoel F
authors.initials: MF
authors.lastname: Biancardi
authors.affiliation: Department of Histology, Embriology and Cell Biology, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Mara R
authors.initials: MR
authors.lastname: Marques
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, University Estadual Paulista - UNESP, São José do Rio Preto, Brazil.
authors.forename: Patrícia S L
authors.initials: PS
authors.lastname: Vilamaior
authors.affiliation: Department of Histology, Embriology and Cell Biology, Federal University of Goiás, Goiânia, Brazil.
authors.forename: Fernanda C A
authors.initials: FC
authors.lastname: Santos
authors.affiliation: Department of Biology, Laboratory of Microscopy and Microanalysis, University Estadual Paulista - UNESP, São José do Rio Preto, Brazil.|Department of Structural and Functional Biology, State University of Campinas, Campinas, Brazil.
authors.forename: Sebastião R
authors.initials: SR
authors.lastname: Taboga
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D049109:Cell Proliferation / Q000187:drug effects*; D052244:Endocrine Disruptors / Q000633:toxicity*; D047628:Estrogen Receptor alpha / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005849:Gerbillinae; D006965:Hyperplasia; D008297:Male; D010636:Phenols / Q000633:toxicity*; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018570:Risk Assessment; D046468:Sexual Development; D017154:Stromal Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000633:toxicity; D015854:Up-Regulation; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D010636:Phenols; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: bisphenol-A; endocrine-disrupting chemicals; female prostate; gerbil; oestrogen receptor-alpha