title: The recent progress of the mechanism and regulation of tumor necrosis in colorectal cancer.
abstract: In colorectal cancer (CRC), despite the complex inducing and regulating mechanism in necrosis progress, the prognostic value of tumor necrosis has been reported. It is generally recognized that necrosis is associated with many process involving severe hypoxia, inflammatory responses and angiogenesis, all of which contribute to promote tumor growth and poor prognosis. In addition to local hypoxia, regulation by RIP kinase and the conversion from apoptosis to necrosis can result in necrosis also. Recent studies showed necrosis can be a histopathologic characteristic for special molecular phenotype of CRC. A novel and attractive complementary treatment, tumor necrosis therapy, using radiolabelled compounds avid for necrosis has emerged. However, the complicated regulatory mechanisms of tumor necrosis were rarely reported in CRC, and we collected and reviewed these effect and relevance in CRC.
authors.affiliation: Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China. Chenlr999@163.com.|Department of Pathology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, China. Chenlr999@163.com.
authors.forename: Lirong
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D015179:Colorectal Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009336:Necrosis
keywords: Angiogenesis; HIF; Hypoxia; Necrosis; Tumor-associated inflammation