title: Impact of autoimmune risk alleles on the immune system.
abstract: Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research.
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA 02142 USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Ray
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, MA 02142 USA ; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129 USA ; Department of Medicine, Harvard Medical School, Boston, MA 02114 USA.
authors.forename: Nir
authors.initials: N
authors.lastname: Hacohen