title: FRZB up-regulation is correlated with hepatic metastasis and poor prognosis in colon carcinoma patients with hepatic metastasis.
abstract: Frizzled-related protein (FRZB) was up-regulated in hepatic metastasis samples compared with primary colon cancer samples in our previous work. However, the clinical relevance of FRZB in colon cancer hepatic metastasis remains uncertain. The aim of this study was to assess the prognostic value of FRZB in patients with colon carcinoma hepatic metastasis after hepatic resection. FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma that underwent hepatic resection. The relation between FRZB expression and clinicopathologic factors and long-term prognosis in these 136 patients was retrospectively examined. The prognostic significance of negative or positive FRZB expression in colon carcinoma hepatic metastasis was assessed using Kaplan-Meier survival analysis and log-rank tests. Positive expression of FRZB was correlated with liver metastasis of colon cancer. Univariate analysis indicated significantly worse overall survival (OS) for patients with a positive FRZB expression in colon carcinoma hepatic metastasis than for patients with a negative FRZB expression. Multivariate analysis showed positive-FRZB in colon carcinoma hepatic metastasis to be an independent prognostic factor for OS after hepatic resection (P = 0.001). Positive expression of FRZB was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis. FRZB could be a novel predictor for poor prognosis of patients with colon carcinoma hepatic metastasis after hepatic resection.
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Gynecology and Obstetrics, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University Shaoxing 312000, Zhejiang Province, P. R. China ; Department of Gastrointestinal Surgery, Taizhou Hospital, Wenzhou Medical University Linhai 317000, Zhejiang Province, P.R. China.
authors.forename: Huanrong
authors.initials: H
authors.lastname: Lan
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cancer Chemotherapy and Radiotherapy, Yinzhou Hospital Affiliated to Medical School of Ningbo University Ningbo 315040, Zhejiang Province, P. R. China.
authors.forename: Guoming
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, Zhejiang Province, P.R. China.
authors.forename: Lisong
authors.initials: L
authors.lastname: Teng
authors.affiliation: Department of Gastrointestinal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University Shaoxing 312000, Zhejiang Province, P. R. China ; Department of Gastrointestinal Surgery, Taizhou Hospital, Wenzhou Medical University Linhai 317000, Zhejiang Province, P.R. China.
authors.forename: Ketao
authors.initials: K
authors.lastname: Jin
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D016009:Chi-Square Distribution; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D000099274:Frizzled-Related Proteins
chemical_list: D014408:Biomarkers, Tumor; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D000099274:Frizzled-Related Proteins
keywords: Colon carcinoma; frizzled-related protein (FRZB); hepatic metastasis; prognosis