title: Use of DNA transposons for functional genetic screens in mouse models of cancer.
abstract: Cancer is a very heterogeneous disease with complex genetic interactions. In recent years, the systematic sequencing of cancer genomes has provided information to design personalized therapeutic interventions. However, the complexity of cancer genomes commonly makes it difficult to identify specific genes involved in tumour development or therapeutic responsiveness. The generation of mouse models of cancer using transposon-mediated approaches has provided a powerful tool to unveil the role of key genes during cancer development. Here we will discuss how the use of forward and reverse genetic approaches mediated by DNA transposons can support the investigation of cancer pathogenesis, including the identification of cancer promoting mechanisms and potential therapeutic targets.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
authors.forename: Camino
authors.initials: C
authors.lastname: Bermejo-Rodríguez
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK; Department of Molecular and Clinical Cancer Medicine, National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK. Electronic address: pedro.perez-mancera@liverpool.ac.uk.
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Pérez-Mancera
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004195:Disease Models, Animal; D005820:Genetic Testing; D006801:Humans; D051379:Mice; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements