title: Unconventional screening approaches for antibiotic discovery.
abstract: The dramatic rise in microbial drug resistance in recent years has led to ongoing searches for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of new antibacterial drugs in discovery and development pipelines using traditional approaches has prompted a variety of unconventional and disruptive strategies for antibacterial drug discovery. Herein, we review recent nontraditional approaches that have been piloted for early drug discovery efforts. These unique methodologies open new avenues for finding the next generation of antimicrobials.
authors.affiliation: M.G. DeGroote Institute for Infectious Disease Research, and Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada.
authors.forename: Maya A
authors.initials: MA
authors.lastname: Farha
authors.affiliation: M.G. DeGroote Institute for Infectious Disease Research, and Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Brown
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology / Q000517:prevention & control; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000639:trends
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotic discovery; high-throughput screening; unconventional methodologies