title: Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.
abstract: Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function. BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect reproductive organ development, brain development, metabolic disease and post-natal behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane) and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this effective metabolizing system is weak in the fetus. In the present study, we demonstrated that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the fetus and newborn pups, and was increased to the same level as BPA post-partum. In conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism during the perinatal period, suggesting that the metabolism of individual Bisphenol analogs requires assessment to properly gauge their risks.
authors.affiliation: Laboratory of Veterinary Biochemistry, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069-8501, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Yabusaki
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Iwano
authors.forename: Sumito
authors.initials: S
authors.lastname: Tsushima
authors.forename: Nanako
authors.initials: N
authors.lastname: Koike
authors.forename: Naoko
authors.initials: N
authors.lastname: Ohtani
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tanemura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yokota
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001559:Benzhydryl Compounds / Q000378:metabolism*; D004968:Estrogens, Non-Steroidal / Q000378:metabolism; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D005466:Fluorocarbons; D000098826:Bisphenol A Compounds; D000098833:Bisphenol F Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D014453:Glucuronosyltransferase; D010636:Phenols; D012333:RNA, Messenger; C000611125:UGT2B1 protein, mouse; C583074:bisphenol AF; D005466:Fluorocarbons; D000098826:Bisphenol A Compounds; C008745:4,4'-bisphenol F; D000098833:Bisphenol F Compounds