title: [Bioavailability and factors influencing its rate].
abstract: Bioavailability can be defined as the rate and range of active ingredient absorption, when it becomes available in the systemic circulation or at the desired site of drug action, respectively. Drug bioavailability after oral administration is affected by anumber of different factors, including physicochemical properties of the drug, physiological aspects, the type of dosage form, food intake, biorhythms, and intra- and interindividual variability of the human population. This article is the first from the series dealing with the bioavailability and methods leading to its improvement. The aim of the present paper is to provide an overview of aspects influencing the rate of bioavailability after oral administration of the active ingredient. Subsequentarticles will provide detailed descriptions of methods used for dug bioavailability improvement, which are here only summarized.
authors.forename: Barbora
authors.initials: B
authors.lastname: Vraníková
authors.forename: Jan
authors.initials: J
authors.lastname: Gajdziok
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D012995:Solubility
chemical_list: D004364:Pharmaceutical Preparations
keywords: bioavailability drug solubility poorly soluble drugs factors influencing bioavailability.