title: Role of 2-Fluoro-2-Deoxyglucose PET/Computed Tomography in Carcinoma of Unknown Primary.
abstract: FDG-PET/CT is a potentially useful imaging modality in the setting of Carcinoma of Unknown Primary (CUP) from various aspects. The central question is detection of site of primary, where most studies have documented the pooled sensitivity and specificity of FDG PET/CT in the range of 80%-85% and a tumor detection rate (after the failure of conventional imaging procedures) between 30%-37%. The heterogeneity in the (i) population studied and (ii) criteria used for labelling patient as of unknown primary, have been the prime reason for widely varying result amongst various studies. Initiating appropriate treatment strategies owing to simultaneous whole body disease staging can be regarded an added utility PET/CT, even in the case of failure of primary tumor detection. FDG-PET/CT changed the patient management in around 35% of patients (studies reporting heterogeneous results ranging from 18.2% to 60%). The futuristic approach will be to monitor molecular targeted and cystostatic therapies with FDG-PET/CT which obviously has advantages than anatomical imaging alone.
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra 400012, India; Department of Nuclear Medicine and PET-CT, Curie-Manavata Cancer Centre, Mumbai Naka, Nashik, Maharashtra 422004, India.
authors.forename: Alok S
authors.initials: AS
authors.lastname: Pawaskar
authors.affiliation: Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Jerbai Wadia Road, Parel, Mumbai, Maharashtra 400012, India. Electronic address: drsanb@yahoo.com.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Carcinoma of unknown primary; FDG PET/CT; Imaging