title: Hepatotoxicity mechanisms of isoniazid: A mini-review.
abstract: Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH-induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity.
authors.affiliation: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.|Department of Pharmacology, Faculty of Pharmacy, University of Gezira, Wad-Medani, Sudan.
authors.forename: Hozeifa M
authors.initials: HM
authors.lastname: Hassan
authors.affiliation: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Guo
authors.affiliation: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.|Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
authors.forename: Bashir A
authors.initials: BA
authors.lastname: Yousef
authors.affiliation: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.|Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China.|Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Luyong
authors.affiliation: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, China.|State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhenzhou
mesh_terms: D000995:Antitubercular Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D000072467:Cytochrome P450 Family 2; D006801:Humans; D007538:Isoniazid / Q000493:pharmacokinetics / Q000633:toxicity*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D003577:Cytochrome P-450 Enzyme System; C110332:CYP2F1 protein, human; D000072467:Cytochrome P450 Family 2; D007538:Isoniazid
keywords: CYP2E1; hepatotoxicity mechanisms; isoniazid