title: Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.
abstract: The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the NIH convened a workshop in late October 2014 entitled "Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits." Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying "-omics" technologies to understand interorgan crosstalk and biological networking systems during PA, and the need to establish an infrastructure of clinical trial sites with sufficient expertise to incorporate mechanistic outcome measures into adequately sized human PA trials. Identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine.
authors.affiliation: East Carolina Diabetes and Obesity Institute, Departments of Physiology and Kinesiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. Electronic address: neuferp@ecu.edu.
authors.forename: P Darrell
authors.initials: PD
authors.lastname: Neufer
authors.affiliation: UAB Center for Exercise Medicine and Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: Marcas M
authors.initials: MM
authors.lastname: Bamman
authors.affiliation: Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Muoio
authors.affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.affiliation: UC Irvine Institute for Clinical and Translational Science and Department of Pediatrics, University of California, Irvine, CA 92697, USA.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Cooper
authors.affiliation: Translational Research Institute for Metabolism and Diabetes, Florida Hospital - Sanford-Burnham Medical Research Institute, Orlando, FL 32804, USA.
authors.forename: Bret H
authors.initials: BH
authors.lastname: Goodpaster
authors.affiliation: Departments of Biomedical Sciences, Medical Pharmacology and Physiology, and Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA.
authors.forename: Frank W
authors.initials: FW
authors.lastname: Booth
authors.affiliation: Division of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Kohrt
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, MA Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gerszten
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Mattson
authors.affiliation: Department of Kinesiology, McGill University Health Center, McGill University, Montreal, QC H2W 1S4, Canada.
authors.forename: Russell T
authors.initials: RT
authors.lastname: Hepple
authors.affiliation: Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA.
authors.forename: William E
authors.initials: WE
authors.lastname: Kraus
authors.affiliation: Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Michael B
authors.initials: MB
authors.lastname: Reid
authors.affiliation: Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA 95616, USA.
authors.forename: Sue C
authors.initials: SC
authors.lastname: Bodine
authors.affiliation: Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, PA 15261, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Jakicic
authors.affiliation: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Fleg
authors.affiliation: National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Williams
authors.affiliation: National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Lyndon
authors.initials: L
authors.lastname: Joseph
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Evans
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Padma
authors.initials: P
authors.lastname: Maruvada
authors.affiliation: National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Rodgers
authors.affiliation: National Institute of Nursing Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Roary
authors.affiliation: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Amanda T
authors.initials: AT
authors.lastname: Boyce
authors.affiliation: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Jonelle K
authors.initials: JK
authors.lastname: Drugan
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: James I
authors.initials: JI
authors.lastname: Koenig
authors.affiliation: Center for Scientific Review, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Ingraham
authors.affiliation: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Danuta
authors.initials: D
authors.lastname: Krotoski
authors.affiliation: Office of Disease Prevention, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Garcia-Cazarin
authors.affiliation: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Joan A
authors.initials: JA
authors.lastname: McGowan
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Maren R
authors.initials: MR
authors.lastname: Laughlin
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D019295:Computational Biology / Q000379:methods; D006262:Health; D006801:Humans; D009043:Motor Activity