title: Bio-inspired Maillard-Like reactions enable a simple and sensitive assay for colorimetric detection of methylglyoxal.
abstract: A simple and selective assay for detecting methylglyoxal (MGO), a metabolite associated with diabetes, was developed by combining a bio-inspired chemical reaction with the anti-aggregation of gold nanoparticles. This assay could detect MGO at as low as 1 μM by the naked eye and 0.05 μM by UV/vis spectrometry, within the clinical range marking oxidative stress in diabetes, and demonstrated high selectivity over other physiologically relevant ketones and aldehydes.
authors.affiliation: Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK. m.stevens@imperial.ac.uk.
authors.forename: Shih-Ting
authors.initials: ST
authors.lastname: Wang
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Lin
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Spicer
authors.forename: Molly M
authors.initials: MM
authors.lastname: Stevens
mesh_terms: D003124:Colorimetry / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D010316:Particle Size; D011765:Pyruvaldehyde / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties
chemical_list: D011765:Pyruvaldehyde