title: Poikilodermatous mycosis fungoides: clinical and histopathological analysis of a case and literature review.
abstract: Poikilodermatous mycosis fungoides is a rare distinct clinical variant of cutaneous T-cell lymphoma (CTCL), formerly referred to as poikiloderma vasculare atrophicans or parapsoriasis variegata. Mycosis fungoides (MF) is a malignant neoplasm of T-lymphocyte origin, most commonly memory CD4+ T-cells.We report here a patient with generalized poikilodermatous skin lesions whose diagnosis of mycosis fungoides was made only a few years after the onset of his disease due to its bizarre clinical behavior and a natural reluctance to diagnose this disease in children and adolescents.The variability of atypical clinical presentations of MF and its similarity to benign inflammatory and noninflammatory skin disorders may become a source of considerable confusion and controversy, challenging a dermatologist to make a precise diagnosis. Therefore, scrupulous clinicopathological correlation is an absolute necessity.
authors.affiliation: Department of Dermatology, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus.
authors.forename: Oleg
authors.initials: O
authors.lastname: Pankratov
authors.affiliation: Department of Dermatology, Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus. Corresponding author: svetlana.gradova@gmail.com.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Gradova
authors.affiliation: Department of Dermatology, City Clinical Skin and Venereal Diseases Clinic, Minsk, Belarus.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Tarasevich
authors.affiliation: Department of Dermatology, Belarusian State Medical University, Minsk, Belarus.
authors.forename: Valentin
authors.initials: V
authors.lastname: Pankratov
mesh_terms: D000328:Adult; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D008297:Male; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers