title: Evaluation of YB-1 levels in patients with endometriosis.
abstract: OBJECTIVE
  The objective of this study is the evaluation of serum YB-1 levels in the diagnosis of endometriosis.
  
  
  METHODS
  Serum samples of 12 patients with histologically confirmed endometriosis and of 10 control patients were collected. Western blot analysis was used to assess serum YB-1 levels. Groups were compared with Student's t-test or, if not normally distributed, with the Mann-Whitney test. Sensitivity and specificity for the potential diagnostic performance of serum YB-1 were assessed by receiver operating characteristic (ROC) curves.
  
  
  RESULTS
  Serum YB-1 levels were significantly higher in patients with endometriosis (=0.004). The area under the curve was 0.867 (95% confidence interval 0.714-1.019) with sensitivity and specificity of 83.3% and 70% respectively.
  
  
  CONCLUSIONS
  Serum YB-1 levels in patients with endometriosis are significantly higher compared to control patients and may be used as a potential diagnostic biomarker for endometriosis.
authors.affiliation: University of Lübeck, Department of Obstetrics and Gynecology, Lübeck, Germany. Electronic address: Thorben.Ahrens@uksh.de.
authors.forename: Thorben
authors.initials: T
authors.lastname: Ahrens
authors.affiliation: University of Lübeck, Department of Obstetrics and Gynecology, Lübeck, Germany; Laboratory of Clinical Immunology and Allergy-LIM60, University of São Paulo School of Medicine, São Paulo, Brazil.
authors.forename: Cassia G T
authors.initials: CG
authors.lastname: Silveira
authors.affiliation: University of Lübeck, Department of Obstetrics and Gynecology, Lübeck, Germany.
authors.forename: Constanze
authors.initials: C
authors.lastname: Banz-Jansen
authors.affiliation: University of Lübeck, Department of Obstetrics and Gynecology, Lübeck, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Rody
authors.affiliation: University of Lübeck, Department of Obstetrics and Gynecology, Lübeck, Germany; Diakonissenkrankenhaus Karlsruhe Rüppurr, Department of Gynecology and Obstetrics, Karlsruhe, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Hornung
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015153:Blotting, Western; D004715:Endometriosis / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D005260:Female; D006801:Humans; D010049:Ovarian Diseases / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D012372:ROC Curve; D012680:Sensitivity and Specificity; D015854:Up-Regulation; D051840:Y-Box-Binding Protein 1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human
keywords: Biomarkers; Diagnosis; Endometriosis