title: Age-Related Changes in Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR1) and Receptor 2 (sVEGFR2) in Healthy Japanese Subjects.
abstract: We measured serum soluble vascular endothelial growth factor receptor 1 (sVEGFR1) and receptor 2 (sVEGFR2) levels in healthy Japanese individuals in order to establish a reference value using a specific ELISA. Significant differences were observed in serum sVEGFR1 and sVEGFR2 levels between children and adults. To demonstrate the usefulness of the reference value for children, we measured serum sVEGFR1 and sVEGFR2 levels in children with diarrhea positive (D+) hemolytic uremic syndrome (HUS) as a preliminary study. Serum sVEGFR2 levels in children with HUS were markedly higher than those in healthy children from the onset of D + HUS. The reference value for healthy children in the present study will allow normal and pathological conditions to be discriminated from each other in future study.
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba 288-0025 Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba 288-0025 Japan.
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Mita
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba 288-0025 Japan.
authors.forename: Testuri
authors.initials: T
authors.lastname: Kodama
authors.affiliation: Department of Pediatrics, Nagoya Daini Red Cross Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, 466-8650 Japan.
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Gotoh
authors.affiliation: Department of Pediatrics, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-Ku, Hamamatsu, Shizuoka 430-8558 Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujita
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba 288-0025 Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukui
authors.affiliation: Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba 288-0025 Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Masuzawa
keywords: Endothelial growth factor (VEGF); Hemolytic uremic syndrome (HUS); Soluble VEGF receptor-1 (sVEGFR1); Soluble VEGF receptor-2 (sVEGFR2); Vascular