title: Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells.
abstract: The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti-inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe3 O4 nanoparticles (nano-Fe3 O4 ) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(l-lysine) (PLL). Physico-chemical studies were performed to obtain a high upload of curcumin in Fe3 O4 nanoparticles. Nano-Fe3 O4 were then tested against an ovarian cancer cell line, SKOV-3, to demonstrate their therapeutic efficacy.
authors.affiliation: CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. mancarella.serena@gmail.com.
authors.forename: Serena
authors.initials: S
authors.lastname: Mancarella
authors.affiliation: CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. valegre86@hotmail.it.
authors.forename: Valentina
authors.initials: V
authors.lastname: Greco
authors.affiliation: CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. frabal84@alice.it.|Dipartimento di Beni Culturali, Università del Salento, via Dalmazio Birago 64, 73100, Lecce, Italy. frabal84@alice.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Baldassarre
authors.affiliation: Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Campus Ecotekne, S.P. 6, Lecce-Monteroni, Lecce, Italy. danielevergara@libero.it.|Laboratory of Clinical Proteomic, "Giovanni Paolo II" Hospital, ASL-Lecce, Italy. danielevergara@libero.it.
authors.forename: Daniele
authors.initials: D
authors.lastname: Vergara
authors.affiliation: Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Campus Ecotekne, S.P. 6, Lecce-Monteroni, Lecce, Italy. michele.maffia@unisalento.it.|Laboratory of Clinical Proteomic, "Giovanni Paolo II" Hospital, ASL-Lecce, Italy. michele.maffia@unisalento.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Maffia
authors.affiliation: CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. stefano.leporatti@nanotec.cnr.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Leporatti
mesh_terms: D045744:Cell Line, Tumor; D003474:Curcumin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D000067493:Dynamic Light Scattering; D004573:Electrolytes / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D004573:Electrolytes; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D011108:Polymers; C000499:ferric oxide; D003474:Curcumin
keywords: cancer; curcumin; drug delivery; nanoparticles; polymer