title: Mouse genetic models for temporomandibular joint development and disorders.
abstract: The temporomandibular joint (TMJ) is a synovial joint essential for hinge and sliding movements of the mammalian jaw. Temporomandibular joint disorders (TMD) are dysregulations of the muscles or the TMJ in structure, function, and physiology, and result in pain, limited mandibular mobility, and TMJ noise and clicking. Although approximately 40-70% adults in the USA have at least one sign of TMD, the etiology of TMD remains largely unknown. Here, we highlight recent advances in our understanding of TMD in mouse models.
authors.affiliation: Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.|Center for Craniofacial Research, UTHealth, Houston, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.affiliation: Department of Diagnostic & Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.|Center for Craniofacial Research, UTHealth, Houston, TX, USA.
authors.forename: J
authors.initials: J
authors.lastname: Iwata
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005157:Facial Pain / Q000503:physiopathology; D006801:Humans; D008334:Mandible; D051379:Mice; D023421:Models, Animal; D008957:Models, Genetic; D016059:Range of Motion, Articular; D013704:Temporomandibular Joint / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D013705:Temporomandibular Joint Disorders / Q000235:genetics* / Q000503:physiopathology; D014157:Transcription Factors
chemical_list: D014157:Transcription Factors
keywords: bones and joints; craniofacial; developmental disorders; genetics; mouse model; temporomandibular joint disorders