title: Steroid-responsive polyradiculopathy in association with focal segmental glomerulosclerosis.
abstract: An 80-year-old woman presented with simultaneous increasing muscle weakness and nephrotic syndrome. A renal biopsy confirmed focal segmental glomerulosclerosis (FSGS). Her neurological diagnosis best fitted with a Guillain-Barre-like syndrome. There have been several cases of FSGS in combination with both conventional and atypical Guillain-Barre syndrome (GBS). Our patient was treated with high-dose steroids and resolution of both nephrotic syndrome and neurological symptoms occurred over 6 months. This article reviews all previously published presentations of this nature and discusses putative mechanisms for the development of concurrent FSGS and GBS.
authors.affiliation: Aberdeen Royal Infirmary , Aberdeen , UK.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Chapman
authors.affiliation: Aberdeen Royal Infirmary , Aberdeen , UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Gamble
authors.affiliation: Raigmore Hospital , Inverness , UK.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Pollock
authors.affiliation: Raigmore Hospital , Inverness , UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Joss
keywords: FSGS; Guillain–Barre syndrome; glucocorticoid therapy