title: Application in Europe of a urine-based rapid diagnostic test for confirmation of Schistosoma mansoni infection in migrants from endemic areas.
abstract: In February 2015, a male patient from Eritrea with persistent abdominal pain and rectal bleeding was diagnosed with Schistosoma mansoni infection upon examination of a rectal biopsy. In May 2015, repeated stool microscopy identified S. mansoni infection in another Eritrean patient with abdominal pain and considerable eosinophilia (34%). Use of point-of-care circulating cathodic antigen (POC-CCA) tests on urine confirmed S. mansoni infection in both patients. Wider application of non-invasive POC-CCA urine tests will improve schistosomiasis diagnosis and clinical management in migrants.
authors.affiliation: Institute of Medical Microbiology and Hygiene, Saarland University, Homburg/Saar, Germany.
authors.forename: S L
authors.initials: SL
authors.lastname: Becker
authors.forename: H
authors.initials: H
authors.lastname: Marti
authors.forename: S
authors.initials: S
authors.lastname: Zimmermann
authors.forename: D
authors.initials: D
authors.lastname: Vidacek
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
authors.forename: J
authors.initials: J
authors.lastname: Utzinger
authors.forename: P A
authors.initials: PA
authors.lastname: Schnabel
authors.forename: R M
authors.initials: RM
authors.lastname: Bohle
mesh_terms: D000293:Adolescent; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000947:Antigens, Helminth / Q000652:urine*; D001706:Biopsy; D019411:Clinical Laboratory Techniques; D019017:Eritrea; D005243:Feces / Q000469:parasitology; D005858:Germany; D006023:Glycoproteins; D015801:Helminth Proteins; D006801:Humans; D008297:Male; D019095:Point-of-Care Systems; D011223:Praziquantel / Q000627:therapeutic use; D012002:Rectal Diseases; D012550:Schistosoma mansoni / Q000276:immunology* / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000175:diagnosis* / Q000188:drug therapy / Q000652:urine*; D012680:Sensitivity and Specificity; D014171:Transients and Migrants; D014195:Travel; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; C091532:CCA protein, Schistosoma mansoni; D006023:Glycoproteins; D015801:Helminth Proteins; D011223:Praziquantel