title: Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The Mayo Clinic Experience from 1977 to 2013.
abstract: The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0% (n = 7) and of BC 4.9% (n = 17). The majority of the patients with BC were men (61%) diagnosed on routine screening (77%) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43% died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA.
authors.forename: Naykky
authors.initials: N
authors.lastname: Singh Ospina
authors.affiliation: Section of Endocrine Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Geoffrey B
authors.initials: GB
authors.lastname: Thompson
authors.affiliation: Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Francis
authors.initials: F
authors.lastname: C Nichols
authors.affiliation: Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Cassivi
authors.affiliation: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905, USA. wyoung@mayo.edu.
authors.forename: William F
authors.initials: WF
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history / Q000628:therapy*; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history / Q000628:therapy*; D015995:Prevalence; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000266:history / Q000628:therapy*; D016896:Treatment Outcome; D055815:Young Adult