title: Interaction of Panax quinquefolius Saponin and Dual Antiplatelets on Vascular Endothelial Function in Rats with Acute Myocardial Infarction.
abstract: The objective of this study is to investigate the interaction of Panax quinquefolius saponin (PQS) and dual antiplatelets (aspirin and clopidogrel) on antiplatelet activity and vascular endothelial function in rats with acute myocardial infarction (AMI). Forty-eight male SD rats were randomly designed into sham group, model group, dual antiplatelet group, and PQS plus dual antiplatelet group. AMI rats were induced by ligation of left anterior descending coronary artery (LAD) and dual antiplatelet agents and additional PQS to dual antiplatelets were intragastrically administered for 28 days, respectively. The ventricular cavity area and cardiac transverse area ratio in PQS + dual antiplatelet group showed a decreased tendency. PAgT(%) decreased significantly in both dual antiplatelet group and PQS + dual antiplatelet group. TXB2 concentration significantly decreased in dual antiplatelet and PQS + dual antiplatelet groups, whereas 6-keto-PGF1 α concentration significantly increased in PQS + dual antiplatelet group. Rats in PQS + dual antiplatelet group demonstrated a significant decrease in plasma ET-1 concentration and an increase in serum NO concentration compared with dual antiplatelet group. The combination therapy of PQS and dual antiplatelets showed some beneficial effects on vascular endothelial function and ventricular remodeling in rats with AMI.
authors.affiliation: Oriental Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100091, China ; Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Baojun
authors.initials: B
authors.lastname: Wang
authors.affiliation: Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China ; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China ; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Shang
authors.affiliation: Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China ; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Centre of Cardiovascular Diseases, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China ; China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Dazhuo
authors.initials: D
authors.lastname: Shi
mesh_terms: D000818:Animals; D001241:Aspirin / Q000008:administration & dosage; D000077144:Clopidogrel; D003331:Coronary Vessels / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D051381:Rats; D012503:Saponins / Q000008:administration & dosage*; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: C079995:Panax quinquefolium saponin; D010975:Platelet Aggregation Inhibitors; D012503:Saponins; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin