title: Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case.
abstract: Background. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare occurrence. Case Presentation. A 21-year-old female presented with headache and left orbital swelling one year after resection of a complete hydatidiform mole followed by adjuvant methotrexate chemotherapy. A metastatic imaging screening revealed multiple metastases in the lungs, brain, and adrenal gland, in addition to the choroid and lacrimal gland. Based on her modified WHO risk factors scoring she was started on chemotherapy and whole brain radiotherapy, which resulted in a complete response. At two-year follow-up, serum b-HCG level was with normal limits; imaging surveillance was uneventful. Conclusion. We present the first case of lacrimal gland metastasis in a young girl from GC relapse.
authors.affiliation: Department of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Naushad A B
authors.identifier: 0000-0002-9458-6107
authors.initials: NA
authors.lastname: Ahamed
authors.affiliation: Gynecology Oncology Unit, Department of Obstetric and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Khalid
authors.initials: K
authors.lastname: Sait
authors.affiliation: Gynecology Oncology Unit, Department of Obstetric and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Nisreen
authors.initials: N
authors.lastname: Anfnan
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Khader
authors.initials: K
authors.lastname: Farwan
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: S H M
authors.initials: SH
authors.lastname: Nizamuddin
authors.affiliation: Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia.
authors.forename: Saleh S
authors.identifier: 0000-0002-3053-7912
authors.initials: SS
authors.lastname: Baeesa