title: Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions.
abstract: Salient events activate the midbrain dopaminergic system and have important impacts on various aspects of mnemonic function, including the stability of hippocampus-dependent memories. Dopamine is also central to modulation of neocortical memory processing, particularly during prefrontal cortex-dependent working memory. Here, we review the current state of the circuitry and physiology underlying dopamine's actions, suggesting that--alongside local effects within hippocampus and prefrontal cortex--dopamine released from the midbrain ventral tegmental area is well positioned to dynamically tune interactions between limbic-cortical circuits through modulation of rhythmic network activity.
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK. Electronic address: emilie.werlen@bristol.ac.uk.
authors.forename: Emilie
authors.initials: E
authors.lastname: Werlen
authors.affiliation: School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK.
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Jones
mesh_terms: D000818:Animals; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*
chemical_list: D004298:Dopamine
keywords: Dopamine; Hippocampus; Learning and memory; Prefrontal cortex; Theta coherence