title: Renal phospholipase A2 receptor in hepatitis B virus-associated membranous nephropathy.
abstract: OBJECTIVE
  This study examined the expression of renal phospholipase A2 receptor (PLA2R) in idiopathic and secondary membranous nephropathy (MN).
  
  
  METHODS
  Patients with biopsy-proven MN and non-MN were enrolled. Renal PLA2R was examined using an anti-PLA2R antibody (anti-PLA2R-Ab), and circulating PLA2R-Ab was detected by indirect immunofluorescence.
  
  
  RESULTS
  Renal PLA2R was detected along the capillary loop in 84% patients with idiopathic MN but not in those with any other primary glomerulonephritis. Only 1 of 38 patients with class V lupus nephritis showed renal PLA2R positive. In hepatitis B virus-associated MN (HBV-MN), 64% showed renal PLA2R positive, and PLA2R overlapped with HBsAg along the capillary loop. In addition, renal PLA2R positivity was closely associated with serum PLA2R-Ab. Renal PLA2R positive was present in all the patients with serum PLA2R-Ab positive and in 53% of patients with serum PLA2R-Ab negative. However, in patients with renal PLA2R negative, serum PLA2R-Ab was all negative.
  
  
  CONCLUSIONS
  Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN. © 2015 S. Karger AG, Basel.
authors.affiliation: Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qionghong
authors.initials: Q
authors.lastname: Xie
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Xue
authors.forename: Zuquan
authors.initials: Z
authors.lastname: Xiong
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Zhuxing
authors.initials: Z
authors.lastname: Sun
authors.forename: Yueheng
authors.initials: Y
authors.lastname: Ren
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Zhu
authors.forename: Chuan-Ming
authors.initials: CM
authors.lastname: Hao
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology / Q000378:metabolism; D015433:Glomerulonephritis, Membranous / Q000209:etiology / Q000378:metabolism*; D057809:HEK293 Cells; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D019694:Hepatitis B, Chronic / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D008181:Lupus Nephritis / Q000150:complications / Q000378:metabolism; D008297:Male; D054507:Receptors, Phospholipase A2 / Q000276:immunology / Q000378:metabolism*; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D001323:Autoantibodies; D006514:Hepatitis B Surface Antigens; D054507:Receptors, Phospholipase A2