title: Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease.
abstract: The present study deals with the effects of rimonabant on oxidative/nitrosative stress in high diet- (HFD-) induced experimental nonalcoholic fatty liver disease (NAFLD). Male mice C57BL/6 were divided into the following groups: control group fed with control diet for 20 weeks (C; n = 6); group fed with HFD for 20 weeks (HF; n = 6); group fed with standard diet and treated with rimonabant after 18 weeks (R; n = 9); group fed with HFD and treated with rimonabant after 18 weeks (HFR; n = 10). Daily dose of rimonabant (10 mg/kg) was administered to HFR and R group by oral gavage for two weeks. Treatment induced a decrease in hepatic malondialdehyde concentration in HFR group compared to HF group (P < 0.01). The concentration of nitrites + nitrates in liver was decreased in HFR group compared to HF group (P < 0.01). Liver content of reduced glutathione was higher in HFR group compared to HF group (P < 0.01). Total liver superoxide dismutase activity in HFR group was decreased in comparison with HF group (P < 0.01). It was found that rimonabant may influence hepatic iron, zinc, copper, and manganese status. Our study indicates potential usefulness of cannabinoid receptor type 1 blockade in the treatment of HFD-induced NAFLD.
authors.affiliation: Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Jorgačević
authors.affiliation: Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Dušan
authors.initials: D
authors.lastname: Mladenović
authors.affiliation: Institute for Medical Research, Military Medical Academy, 11000 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Ninković
authors.affiliation: Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Vesković
authors.affiliation: Institute of Medical Chemistry, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Dragutinović
authors.affiliation: Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Vatazević
authors.affiliation: Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Danijela
authors.initials: D
authors.lastname: Vučević
authors.affiliation: Institute of Digestive Diseases, Clinical Center of Serbia, 11000 Belgrade, Serbia.
authors.forename: Rada
authors.initials: R
authors.lastname: Ješić Vukićević
authors.affiliation: Institute of Pathophysiology "Ljubodrag Buba Mihailović", Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors.forename: Tatjana
authors.initials: T
authors.lastname: Radosavljević
mesh_terms: D000818:Animals; D063387:Cannabinoid Receptor Antagonists / Q000494:pharmacology*; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D000077285:Rimonabant; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D063387:Cannabinoid Receptor Antagonists; D008670:Metals; D009566:Nitrates; D009573:Nitrites; D010880:Piperidines; D011720:Pyrazoles; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione; D000077285:Rimonabant