title: The Chemical Basis of Fungal Bioluminescence.
abstract: Many species of fungi naturally produce light, a phenomenon known as bioluminescence, however, the fungal substrates used in the chemical reactions that produce light have not been reported. We identified the fungal compound luciferin 3-hydroxyhispidin, which is biosynthesized by oxidation of the precursor hispidin, a known fungal and plant secondary metabolite. The fungal luciferin does not share structural similarity with the other eight known luciferins. Furthermore, it was shown that 3-hydroxyhispidin leads to bioluminescence in extracts from four diverse genera of luminous fungi, thus suggesting a common biochemical mechanism for fungal bioluminescence.
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Purtov
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Valentin N
authors.initials: VN
authors.lastname: Petushkov
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Baranov
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
authors.forename: Konstantin S
authors.initials: KS
authors.lastname: Mineev
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Natalja S
authors.initials: NS
authors.lastname: Rodionova
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
authors.forename: Zinaida M
authors.initials: ZM
authors.lastname: Kaskova
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
authors.forename: Aleksandra S
authors.initials: AS
authors.lastname: Tsarkova
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Alexei I
authors.initials: AI
authors.lastname: Petunin
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Bondar
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Emma K
authors.initials: EK
authors.lastname: Rodicheva
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
authors.forename: Svetlana E
authors.initials: SE
authors.lastname: Medvedeva
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601 (Japan).
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Oba
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601 (Japan).
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Oba
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Arseniev
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia).|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia).
authors.forename: Sergey
authors.initials: S
authors.lastname: Lukyanov
authors.affiliation: Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia). jigitelson@gmail.com.
authors.forename: Josef I
authors.initials: JI
authors.lastname: Gitelson
authors.affiliation: Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia). ivyamp@ibch.ru.|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia). ivyamp@ibch.ru.
authors.forename: Ilia V
authors.initials: IV
authors.lastname: Yampolsky
mesh_terms: D001688:Biological Products; D005658:Fungi / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*
chemical_list: D001688:Biological Products
keywords: bioluminescence; bioorganic chemistry; biosynthesis; luciferin; natural products