title: Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino Mice.
abstract: Prevention of cancer through dietary intervention has recently gained significant recognition. Cardamom (Elettaria cardamomum), a dietary phytoproduct, is a popular spice that is regularly used as a flavoring agent in various cuisines, and is much valued for its medicinal properties. In the present study, the cancer chemopreventive potential of cardamom was investigated against benzo(α)pyrene [B(α)P]-induced forestomach papillomagenesis in mice. Results showed that treatment with cardamom [(B(α)P + cardamom] reduced tumor incidence and multiplicity significantly (P<0.001) by 41.67% and 74.55%, respectively, compared to that of the B(α)P control group. Biochemical assays revealed a significant enhancement in the hepatic activities of glutathione-S-transferases (P<0.01), superoxide dismutase (P<0.01), glutathione peroxidase (P<0.001), and catalase (P<0.001) in mice treated with cardamom compared with the control. Furthermore, the nonenzymatic antioxidant glutathione was significantly (P<0.001) increased in the cardamom-treated group, whereas the lipid peroxidation level along with lactate dehydrogenase activity exhibited a significant (P<0.01) reduction with cardamom treatment compared to the control. These results suggest that cardamom has the potential to become a pivotal chemopreventive agent against forestomach cancer.
authors.affiliation: Department of Histology, College of Medicine, University of Hail, Hail, Saudi Arabia.
authors.forename: Samir
authors.initials: S
authors.lastname: Qiblawi
authors.affiliation: Department of Biochemistry, College of Medicine, University of Hail, Saudi Arabia.
authors.forename: Sasikumar
authors.initials: S
authors.lastname: Dhanarasu
authors.affiliation: Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia; Depatment of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, United Arab Emirates.
authors.forename: Mo'ez Al-Islam
authors.initials: MA
authors.lastname: Faris
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001564:Benzo(a)pyrene / Q000633:toxicity; D028523:Elettaria / Q000737:chemistry*; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001564:Benzo(a)pyrene; D007770:L-Lactate Dehydrogenase; D005978:Glutathione