title: Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways.
abstract: The chemical species involved in H2S signaling remain elusive despite the profound and pleiotropic physiological effects elicited by this molecule. The dominant candidate mechanism for sulfide signaling is persulfidation of target proteins. However, the relatively poor reactivity of H2S toward oxidized thiols, such as disulfides, the low concentration of disulfides in the reducing milieu of the cell and the low steady-state concentration of H2S raise questions about the plausibility of persulfide formation via reaction between an oxidized thiol and a sulfide anion or a reduced thiol and oxidized hydrogen disulfide. In contrast, sulfide oxidation pathways, considered to be primarily mechanisms for disposing of excess sulfide, generate a series of reactive sulfur species, including persulfides, polysulfides and thiosulfate, that could modify target proteins. We posit that sulfide oxidation pathways mediate sulfide signaling and that sulfurtransferases ensure target specificity.
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA..
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Mishanina
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA..
authors.forename: Marouane
authors.initials: M
authors.lastname: Libiad
authors.affiliation: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA..
authors.forename: Ruma
authors.initials: R
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism; D004220:Disulfides / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008706:Methemoglobin / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011077:Polychaeta / Q000378:metabolism; D015398:Signal Transduction; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013440:Sulfides / Q000378:metabolism*; D016999:Sulfur-Reducing Bacteria / Q000378:metabolism; D013466:Sulfurtransferases / Q000737:chemistry / Q000378:metabolism
chemical_list: D004220:Disulfides; D024101:Mitochondrial Proteins; D013438:Sulfhydryl Compounds; D013440:Sulfides; C051552:persulfides; D008706:Methemoglobin; D013466:Sulfurtransferases; D003545:Cysteine; D006862:Hydrogen Sulfide