title: Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II.
abstract: Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma.
authors.affiliation: Department of Gastroenterology, Rheumatology, and Clinical Immunology, Sapporo Medical University, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Akutsu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Adachi
authors.forename: Mai
authors.initials: M
authors.lastname: Isosaka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mita
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Takagi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sasaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Arimura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ishii
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
authors.forename: Takao
authors.initials: T
authors.lastname: Endo
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Shinomura
mesh_terms: D000368:Aged; D001344:Autopsy; D015415:Biomarkers / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000737:chemistry / Q000175:diagnosis*; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D011498:Protein Precursors / Q000032:analysis*; D011516:Prothrombin / Q000032:analysis*; D014812:Vitamin K / Q000032:analysis*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D000509:alpha-Fetoproteins; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin