title: Platelet volume indices are associated with systolic and diastolic cardiac dysfunction, and left ventricular hypertrophy.
abstract: BACKGROUND
  Mean platelet volume (MPV) and platelet distribution width (PDW) are indices that reflect platelet activity. We investigated the association between these platelet indices and left ventricular hypertrophy and cardiac function.
  
  
  METHODS
  We analyzed the data of 1241 patients who were admitted to the Cardiology Department.
  
  
  RESULTS
  Both MPV and PDW were selected as independent factors associated with left ventricular systolic and diastolic dysfunction, and left ventricular hypertrophy. The highest tertile of MPV and PDW was associated with left ventricular systolic dysfunction (left ventricular ejection fraction of <50 %) with an odds ratio of 1.53 and 2.03, respectively, when the respective lowest tertile was used as reference. The highest PDW tertile was associated with left ventricular hypertrophy with an odds ratio of 1.56 (95 % CI, 1.13-2.15) and with dysfunction with an odds ratio of 3.34 (95 % CI, 1.54-7.25).
  
  
  CONCLUSIONS
  Indices of platelet activation (MPV and/or PDW) were independently associated positively with left ventricular hypertrophy and left ventricular systolic and diastolic dysfunction. Whether these platelet indices represent useful markers for identifying individuals at higher risk for thromboembolic disease and organ damage among cardiac patients awaits further investigation.
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Fujita
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Shun
authors.initials: S
authors.lastname: Kizawa
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Takahide
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Sakane
authors.affiliation: Department of Central Clinical Laboratory, Osaka Medical College, Osaka, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ikemoto
authors.affiliation: Department of Central Clinical Laboratory, Osaka Medical College, Osaka, Japan.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sohmiya
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hoshiga
authors.affiliation: Department of Cardiology, Osaka Medical College, Takatsuki-shi Daigaku-machi 2-7, Osaka, 569-8686, Japan. ishizaka@poh.osaka-med.ac.jp.
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D001792:Blood Platelets / Q000166:cytology*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy; D015331:Cohort Studies; D003971:Diastole; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging; D016014:Linear Models; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D013599:Systole; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors