title: Vulvar yolk sac tumor diagnosed during pregnancy, with recurrence during subsequent second pregnancy.
abstract: •Vulvar yolk sac tumor (YST) is an exceptionally rare and aggressive extra-gonadal germ cell tumor, previously only described in 15 cases in the literature.•We present a unique case of vulvar YST diagnosed during pregnancy, treated with systemic chemotherapy, who subsequently recurred during a second pregnancy.•Despite salvage chemotherapy and autologous stem cell transplantation at recurrence, our patient succumbed to her disease, 31 months post diagnosis.
authors.affiliation: Department of Medical Oncology, Mater Hospital, South Brisbane, QLD, Australia ; University of Queensland, Australia.
authors.forename: Wen
authors.initials: W
authors.lastname: Xu
authors.affiliation: University of Queensland - Ochsner Clinical School, Australia.
authors.forename: Ashley
authors.initials: A
authors.lastname: Moon
authors.affiliation: Department of Gynaecologic Oncology, Mater Hospital, South Brisbane, QLD, Australia.
authors.forename: Naven
authors.initials: N
authors.lastname: Chetty
authors.affiliation: Mater Pathology Services, South Brisbane, QLD, Australia.
authors.forename: Rohan
authors.initials: R
authors.lastname: Lourie
authors.affiliation: Department of Medical Oncology, Mater Hospital, South Brisbane, QLD, Australia.
authors.forename: Catherine
authors.initials: C
authors.lastname: Shannon
keywords: Autologous stem cell transplant; Cancer in pregnancy; Extra-gonadol; Germ cell tumor; Vulvar yolk-sac tumor