title: Anaphylactic Shock Secondary to Intravenous Iron Sucrose in Chronic Kidney Disease.
abstract: Intravenous (IV) iron is an essential component of therapy of anemia of chronic kidney disease (CKD). We present a rare case in which iron sucrose was infused to a patient of CKD and resulted in severe anaphylaxis and cardiac arrest minutes after starting the infusion. He was aggressively resuscitated with adrenaline and other measures following which he recovered. The use of parenteral iron is associated with several adverse drug reactions (ADR) which were seen with preparations like iron dextran but became rare with the use of newer safe preparations like iron sucrose or gluconate. The ADR can be mild or can have severe life threatening features like syncope, cardiac arrhythmias, seizures, bronchospasm and rarely cardio respiratory arrest like in our case. Iron sucrose is generally given as a IV infusion of 100-200 mg over 15-30 min and has a very low rate of ADR even with higher doses or bolus injections. But still necessary precautions and appropriate monitoring must be done in all patients. The patients who are allergic to iron sucrose may be treated with other safer preparations or by desensitisation techniques.
authors.affiliation: Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 Maharashtra India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Behera
authors.affiliation: Department of Medicine, Armed Forces Medical College, Pune, Maharashtra India.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Chauhan
authors.affiliation: Department of Medicine, Armed Forces Medical College, Pune, Maharashtra India.
authors.forename: Smriti
authors.initials: S
authors.lastname: Sinha
authors.affiliation: Internal Medicine & Clinical Hematology, Armed Forces Medical College, Pune, Maharashtra India.
authors.forename: Velu
authors.initials: V
authors.lastname: Nair
keywords: Allergic reaction; Anaphylactic shock; Chronic kidney disease; Intravenous iron; Iron sucrose