title: [Research development of the chemical material basis of Alisma orientalis and its toxicity].
abstract: Alisma orientalis is a traditional herb medicine commonly used in clinical. With the increasing report of its toxicity in clinical, the renal toxicity of Alisma orientalis has got gradually attention. This paper systematically reviews the research on the chemical material basis of Alisma orientalis including its chemical composition and toxicity of ingredients; and also declares its toxic ingredients and targets according to Network toxicology. Based on the controversy on renal toxicity of Alisma orientalis, we analyzed the possible reasons that may be associated with renal toxicity. It might be associated with the differences of the material basis composition and regulatory toxicology network, differences in employed processing technology, the metabolic function leading to accumulation of compounds, dosage and duration of the experiment and compatibility. The review provides possible reference and ideas for the quality control and rational use of Alisma orientalis.
authors.forename: Chun-fei
authors.initials: CF
authors.lastname: Wang
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Jun-fei
authors.initials: JF
authors.lastname: Gu
authors.forename: Jia-rui
authors.initials: JR
authors.lastname: Yuan
authors.forename: Bing-jie
authors.initials: BJ
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D034902:Alisma / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D015394:Molecular Structure
chemical_list: D004365:Drugs, Chinese Herbal