title: Second chances.
abstract: An 81-year-old woman presented with light perception vision in her left eye and had pallid swelling of the left optic disk. Temporal artery biopsy was normal. Magnetic resonance imaging revealed enlargement and enhancement of the left orbital optic nerve. There were vitreous cells, but a vitrectomy specimen showed only a benign lymphocytic population. Her vision deteriorated to no light perception in the left eye, and an optic nerve biopsy revealed a diffuse astrocytoma of World Health Organization grade II.
authors.affiliation: Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: lnagia@uab.edu.
authors.forename: Lina
authors.initials: L
authors.lastname: Nagia
authors.affiliation: Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Jennifer I
authors.initials: JI
authors.lastname: Doyle
authors.affiliation: Department of Pathology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Hackney
authors.affiliation: Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Vaphiades
authors.affiliation: Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Lanning B
authors.initials: LB
authors.lastname: Kline
authors.affiliation: Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Marc H
authors.initials: MH
authors.lastname: Levin
mesh_terms: D000369:Aged, 80 and over; D001254:Astrocytoma / Q000175:diagnosis* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009900:Optic Nerve / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010211:Papilledema / Q000175:diagnosis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014786:Vision Disorders / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human
keywords: IDH1 marker; TP53 marker; WHO grade II; optic nerve biopsy; optic nerve glioma/astrocytoma