title: Diseases caused by defects of energy level and loss of coherence in living cells.
abstract: Human and animal diseases are brought about by pathological alterations of production, composition, and conformation of macromolecules and structures in cells. Additional contributing factors include changes in physiological states caused by disturbances of energy supply, energy transduction, energy dissipation in moving or oscillating parts, and parasitic energy consumption. Disturbances of energy states may endanger existence of the system. The cell-mediated immunity (CMI) response of T lymphocytes correlating with their adherence properties was examined using antigen prepared from the serum of inbred laboratory mice strain C3H H(2k) infected with lactate dehydrogenase elevating (LDH) virus. LDH virus is a parasite on the cellular energy system. Significant CMI response was elicited in T lymphocytes prepared from the blood of patients with cancer of different phenotypes, acute myocardial infarctions, schizophrenia, and recurrent spontaneous abortions in early pregnancy from unknown reasons. The CMI response is assumed to monitor transferred information about decreased levels of energy states and decoherence in the cells caused by mitochondrial malfunction, parasitic consumption, production of lactate, and possibly other disturbances. The LDH virus infection or similar pathological processes caused by different agents might be connected with the diseases and monitored by the examined CMI response. A large amount of mitoses with chromosome defects in aborted fetuses suggest increased mutability of genomes caused by defective energy states.
authors.affiliation: Department of Obstetrics and Gynaecology, 1st Faculty of Medicine, Charles University , Prague , Czech Republic .
authors.forename: Anna
authors.initials: A
authors.lastname: Jandová
authors.forename: Jan
authors.initials: J
authors.lastname: Pokorný
authors.forename: Jiří
authors.initials: J
authors.lastname: Pokorný
authors.forename: Jitka
authors.initials: J
authors.lastname: Kobilková
authors.forename: Martina
authors.initials: M
authors.lastname: Nedbalová
authors.forename: Aleš
authors.initials: A
authors.lastname: Čoček
authors.forename: František
authors.initials: F
authors.lastname: Jelínek
authors.forename: Jan
authors.initials: J
authors.lastname: Vrba
authors.forename: Jan
authors.initials: J
authors.lastname: Vrba
authors.forename: Alena
authors.initials: A
authors.lastname: Dohnalová
authors.forename: Jitka
authors.initials: J
authors.lastname: Kytnarová
authors.forename: Jack A
authors.initials: JA
authors.lastname: Tuszyński
authors.forename: Alberto
authors.initials: A
authors.lastname: Foletti
mesh_terms: D000818:Animals; D002470:Cell Survival; D004194:Disease; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007772:Lactate dehydrogenase-elevating virus / Q000502:physiology; D051379:Mice; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology
keywords: Cell-mediated immunity response; LDH virus antigen; acute myocardial infarction; cancer; pathological energy states; schizophrenia; spontaneous abortion from unknown reasons