title: The paradoxical role of IL-17 in atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory disease mediated by innate and adaptive immune responses. In recent years, CD4(+) T cells (Th1, Th2, Treg, and Th17) have been increasingly studied for their role in atherosclerosis pathophysiology, atheroma stability, plaque rupture, and life-threatening acute coronary syndrome. IL-17, a marker cytokine of Th17 cells, has been reported to be involved in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, and asthma. However, its role in atherosclerosis has been poorly characterized. This article provides a comprehensive overview of the role of IL-17 in the development of atherosclerosis and human coronary artery diseases.
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
authors.forename: Fangchen
authors.initials: F
authors.lastname: Gong
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
authors.forename: Zhengxia
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
authors.forename: Jingning
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Jiangsu 210029, China. Electronic address: luxiang66@njmu.edu.cn.
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology*; D003324:Coronary Artery Disease / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020381:Interleukin-17 / Q000276:immunology*; D051379:Mice; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17
keywords: Atherosclerosis; Coronary artery disease; IL-17; Immunity