title: The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels.
abstract: TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.
authors.affiliation: a Department of Physiology ; Seoul National University College of Medicine ; Seoul , Republic of Korea.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Wie
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Kim
authors.forename: Jongyun
authors.initials: J
authors.lastname: Myeong
authors.forename: Kotdaji
authors.initials: K
authors.lastname: Ha
authors.forename: Seung Joo
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Dongki
authors.initials: D
authors.lastname: Yang
authors.forename: Euiyong
authors.initials: E
authors.lastname: Kim
authors.forename: Ju-Hong
authors.initials: JH
authors.lastname: Jeon
authors.forename: Insuk
authors.initials: I
authors.lastname: So
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D020738:Leptin / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D050052:TRPC Cation Channels / Q000378:metabolism / Q000502:physiology*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D020738:Leptin; C400132:RASD1 protein, human; D050052:TRPC Cation Channels; C489571:TRPC4 ion channel; D018631:ras Proteins