title: New Genetic and Genomic Approaches After the Genome-wide Association Study Era--Back to the Future.
abstract: Identification of all human genes and their regulatory regions provides the essential framework for our understanding of the molecular basis of disease. There is a lot of enthusiasm for applying next-generation sequencing methods toward achieving the goals of precision medicine. To do so will require us to go beyond genomics and fundamentally understand how genomics impacts on biology and clinical outcomes through gene-gene and gene-environmental interactions. Clinicians and healthcare systems alike need to embrace the cultural and mindset change needed for the implementation of genomics in the clinic.
authors.affiliation: Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore; Oncology Academic Clinical Program, Duke University-National University of Singapore Graduate Medical School, Singapore; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Joanne
authors.initials: J
authors.lastname: Ngeow
authors.affiliation: Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio; Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio; Germline High Risk Focus Group, CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: engc@ccf.org.
authors.forename: Charis
authors.initials: C
authors.lastname: Eng
mesh_terms: D003695:Delivery of Health Care / Q000379:methods / Q000639:trends*; D004194:Disease / Q000235:genetics*; D004777:Environment; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000639:trends*; D023281:Genomics / Q000379:methods / Q000639:trends*; D006801:Humans; D057285:Precision Medicine / Q000379:methods / Q000639:trends*
keywords: Biology; Genome Wide Association Studies; Next-Generation Sequencing