title: Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging.
abstract: In search for strategies aimed at preventing oxidative threat to female fertility, a possible role of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD(+) dependent enzymes with deacetylase and/or mono-ADP-ribosyltransferase activity, are emerging as key antiaging molecules and regulators in many diseases. Recently, a crucial role for SIRT1 and SIRT3, the main components of sirtuin family, as sensors and guardians of the redox state in oocytes, granulosa cells, and early embryos has emerged. In this context, the aim of the present review is to summarize current knowledge from research papers on the role of sirtuins in female fertility with particular emphasis on the impairment of SIRT1 signalling with oocyte aging. On this basis, the authors wish to build up a framework to promote research on the possible role of sirtuins as targets for future strategies for female fertility preservation.
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy ; Infertility Service, San Salvatore Hospital, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Tatone
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Giovanna
authors.identifier: 0000-0001-9442-6923
authors.initials: G
authors.lastname: Di Emidio
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Vitti
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Michela
authors.identifier: 0000-0002-9910-7187
authors.initials: M
authors.lastname: Di Carlo
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Santini
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: D'Alessandro
authors.affiliation: Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
authors.forename: Stefano
authors.identifier: 0000-0002-5978-0545
authors.initials: S
authors.lastname: Falone
authors.affiliation: Institute of Translational Pharmacology (IFT), National Council of Research (CNR), 67100 L'Aquila, Italy.
authors.forename: Fernanda
authors.identifier: 0000-0003-4528-4660
authors.initials: F
authors.lastname: Amicarelli
mesh_terms: D000375:Aging; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D010053:Ovary / Q000378:metabolism; D018384:Oxidative Stress; D037761:Sirtuins / Q000378:metabolism
chemical_list: D037761:Sirtuins