title: Surgery combined with chemotherapy for recurrent gastric cancer achieves better long-term prognosis.
abstract: BACKGROUND
  Recurrence is the most important factor associated with death of gastric cancer patients after surgery. The aim of this study was to explore the prognosis factors and the effective therapy for recurrent gastric cancer (RGC) patients after radical resection.
  
  
  METHODS
  The clinical data of 144 RGC patients who underwent radical resection from January 1999 to March 2004 were reviewed. The 15 clinicopathological factors and treatment modalities on the survival were analyzed. Univariate and multivariate analyses were performed to investigate the prognostic significance of these factors for RGC.
  
  
  RESULTS
  The early recurrence (<2 years) was found in 90 patients, while late recurrence (≥2 years) occurred in 54 patients. The 2-year cumulative survival rates were 23.8 % for recurrent patients receiving chemotherapy plus surgery vs. 1.2 % in patients having chemotherapy only (p < 0.001), while the median survival time was 11.0 months vs. 6.0 months (p < 0.001). Multivariate analysis indicated TNM stage after the first operation (p = 0.048), iASPP overexpression (p = 0.013), time to recurrence (p < 0.001) and treatment of recurrence (p < 0.001) as independent prognostic factors.
  
  
  CONCLUSIONS
  Surgery combined with chemotherapy for recurrent gastric cancer patients achieves ideal long-term prognosis, which should perform actively.
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin, 300193, China. kongfanming08@163.com.
authors.forename: F
authors.initials: F
authors.lastname: Kong
authors.affiliation: Department of Hematology, Tianjin First Center Hospital, Fukang Road, Tianjin, 300192, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin, 300193, China.
authors.forename: P
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Hematology, Tianjin First Center Hospital, Fukang Road, Tianjin, 300192, China. dr_liyuming@sina.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Oncology, First Teaching Hospital of Tianjin University of TCM, Anshanxi Road, Nankai District, Tianjin, 300193, China. jiayingjie1616@163.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000096:biosynthesis; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D012097:Repressor Proteins / Q000096:biosynthesis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D047908:Intracellular Signaling Peptides and Proteins; C119612:PPP1R13L protein, human; D012097:Repressor Proteins
keywords: Curative gastrectomy; Gastric carcinoma; Prognostic factors; Recurrence