title: Contribution of NRG1 Gene Polymorphisms in Temporal Lobe Epilepsy.
abstract: The purpose of the present study was to investigate the possible association between temporal lobe epilepsy and NRG1 gene polymorphisms. A total of 73 patients and 69 controls were involved in this study. Genomic DNAs from the patients and controls were genotyped by polymerase chain reaction-ligase detection reaction method. There was an association of rs35753505 (T>C) with temporal lobe epilepsy (χ(2) = 6.730, P = .035). The frequency of risk allele C of rs35753505 was significantly higher (69.9%) in patients compared to controls (55.8%) (χ(2) = 6.023, P = .014). Interestingly, the significant difference of NRG1 genotype and allele frequency only existed among males, but not females. In addition, no statistically significant association was found between rs6994992, rs62510682 polymorphisms, and temporal lobe epilepsy. These data indicate that rs35753505 of NRG1 plays an important role in conferring susceptibility to the temporal lobe epilepsy in a Chinese Han population.
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Wen-Ye
authors.initials: WY
authors.lastname: Zhu
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Jiang
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Ling-Juan
authors.initials: LJ
authors.lastname: Cao
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Rui-Li
authors.initials: RL
authors.lastname: Dang
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Mi-Mi
authors.initials: MM
authors.lastname: Tang
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China School of Pharmaceutical Science, Central South University, Changsha, Hunan Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China lihuande1953@126.com.
authors.forename: Huan-De
authors.initials: HD
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics; D002648:Child; D002681:China; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D020890:Neuregulin-1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012727:Sex Characteristics
chemical_list: C094131:NRG1 protein, human; D020890:Neuregulin-1
keywords: GABA; NMDA; NRG1; polymorphism; temporal lobe epilepsy