title: Effect of 0.3% Hydroxypropyl Methylcellulose/Dextran Versus 0.18% Sodium Hyaluronate in the Treatment of Ocular Surface Disease in Glaucoma Patients: A Randomized, Double-Blind, and Controlled Study.
abstract: OBJECTIVE
  To compare the efficacy and safety of 0.3% hydroxypropyl methylcellulose/dextran (HPMC/dextran) and 0.18% sodium hyaluronate (SH) in the treatment of ocular surface disease in patients using antiglaucoma drugs containing preservatives.
  
  
  METHODS
  This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 20 points and/or presence of ocular signs. Patients were randomized to receive either preservative-free 0.3% HPMC/dextran (n=35) or preservative-free 0.18% SH (n=35). Treatment was 1 drop in each eye, 4 times a day. Data were collected at baseline, at day 7 and day 28.
  
  
  RESULTS
  The groups were homogeneous at baseline. At day 28, both treatments showed significant improvements (P<0.05) in the mean OSDI score, lid skin and lid margin inflammation, conjunctival injection, and expressibility of meibomian glands, corneal staining score, fluorescein tear breakup time (FBUT), and Schirmer I test. However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (P<0.05) in the SH group at days 7 and 28, compared to the HPMC/dextran group. FBUT and the Schirmer I test also showed significant improvements (P<0.05) in the SH group compared to the HPMC/dextran group, at day 28. No adverse reactions were observed in either group.
  
  
  CONCLUSIONS
  Preservative-free artificial tear, 0.3% HPMC/dextran, and 0.18% SH, caused a significant relief of the ocular surface disease in glaucoma patients. However, 0.18% SH led to a greater improvement in ocular signs and symptoms than 0.3% HPMC/dextran.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok, Thailand .
authors.forename: Pinnita
authors.initials: P
authors.lastname: Prabhasawat
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok, Thailand .
authors.forename: Ngamkae
authors.initials: N
authors.lastname: Ruangvaravate
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok, Thailand .
authors.forename: Nattaporn
authors.initials: N
authors.lastname: Tesavibul
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University , Bangkok, Thailand .
authors.forename: Maneerat
authors.initials: M
authors.lastname: Thewthong
mesh_terms: D000287:Administration, Topical; D003911:Dextrans / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D065347:Hypromellose Derivatives / Q000008:administration & dosage* / Q000009:adverse effects; D065346:Lubricant Eye Drops / Q000008:administration & dosage*; D008297:Male; D008537:Meibomian Glands / Q000187:drug effects / Q000503:physiopathology; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D003911:Dextrans; D065346:Lubricant Eye Drops; D011310:Preservatives, Pharmaceutical; D065347:Hypromellose Derivatives; D006820:Hyaluronic Acid