title: Altered baseline brain activity differentiates regional mechanisms subserving biological and psychological alterations in obese men.
abstract: Obesity as a chronic disease is a major factor for insulin resistance and Type 2 diabetes, which has become a global health problem. In the present study, we used resting state functional MRI to investigate the amplitude of low frequency fluctuations of spontaneous signal during both hunger and satiety states in 20 lean and 20 obese males. We found that, before food intake, obese men had significantly greater baseline activity in the precuneus and lesser activity in dorsal anterior cingulate cortex (dACC) relative to lean subjects. Furthermore, after food intake, obese males had significantly lesser activity in dACC than lean males. We further found a significant positive correlation between precuneus activation and hunger ratings before food intake, while dACC activity was negatively correlated with plasma insulin levels before and after food intake. These results indicated that both precuneus and dACC may play an important role in eating behavior. While precuneus rather seemed to mediate subjective satiety, dACC levels rather reflected indirect measures of glucose utilization.
authors.affiliation: 1] Department of Anatomy, Tianjin Medical University, Tianjin, China [2] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [3] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [4] Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Anatomy, Tianjin Medical University, Tianjin, China.
authors.forename: Derun
authors.initials: D
authors.lastname: Tian
authors.affiliation: Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.
authors.forename: Chunshui
authors.initials: C
authors.lastname: Yu
authors.affiliation: 1] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [2] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [3] Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.affiliation: 1] Key laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China [2] School of Psychology, Southwest University, Chongqing, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 1] Department of Psychiatry and Psychotherapy, University of Magdeburg, Magdeburg, Germany [2] Clinical Affective Neuroimaging Laboratory, University of Magdeburg, Magdeburg, Germany [3] Leibniz Institute for Neurobiology, Magdeburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006815:Hunger; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology* / Q000523:psychology*; D055815:Young Adult
chemical_list: D007328:Insulin