title: Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report.
abstract: An inflammatory response plays a crucial role in myocardial damage after an acute myocardial infarction.
  
  
  OBJECTIVE
  To measure serum concentrations of several mediators in patients with an acute myocardial infarction (STEMI) and to assess their potential relationship with a risk of coronary instability.
  
  
  METHODS
  The 33 patients with STEMI and 19 healthy volunteers were analyzed. The clinical data were obtained; as well serum concentrations of tryptase, endothelin (ET-1), angiogenin, soluble c-kit, and PDGF were measured.
  
  
  RESULTS
  Patients with STEMI had higher serum tryptase and ET-1 than healthy volunteers (2,5 ± 0,4 ng/mL versus 1,1 ± 0,4 ng/mL and 0,7 ± 0,1 ng/mL versus 0,3 ± 0,1 ng/mL, resp.). Subjects with significant lesion in left anterior descending artery (LAD) had lower serum ET-1 compared to those with normal LAD (0,6 ± 0,2 pg/mL versus 0,9 ± 0,4 pg/mL). Patients with three-vessel coronary artery disease (CAD) had higher level of soluble c-kit compared to those with one- or two-vessel CAD: 19,9 ± 24,1 ng/mL versus 5,6 ± 1,9 ng/mL.
  
  
  CONCLUSIONS
  Elevated serum tryptase and ET-1 may be markers of increased coronary instability; some cytokines may be related to the extension of CAD.
authors.affiliation: University Center for Cardiology, Poland ; Pomeranian Cardiology Centers, Jagalskiego 10, 84-200 Wejherowo, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Lewicki
authors.affiliation: University Center for Cardiology, Poland ; Department of Family Medicine, Medical University of Gdansk, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Siebert
authors.affiliation: Department of Family Medicine, Medical University of Gdansk, Poland.
authors.forename: Natalia
authors.initials: N
authors.lastname: Marek-Trzonkowska
authors.affiliation: Pomeranian Cardiology Centers, Jagalskiego 10, 84-200 Wejherowo, Poland.
authors.forename: Emilia
authors.initials: E
authors.lastname: Masiewicz
authors.affiliation: Department of Family Medicine, Medical University of Gdansk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kolinski
authors.affiliation: Department of Family Medicine, Medical University of Gdansk, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Reiwer-Gostomska
authors.affiliation: Pomeranian Cardiology Centers, Jagalskiego 10, 84-200 Wejherowo, Poland.
authors.forename: Radoslaw
authors.initials: R
authors.lastname: Targonski
authors.affiliation: Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Trzonkowski
mesh_terms: D000368:Aged; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D011446:Prospective Studies; D019009:Proto-Oncogene Proteins c-kit / Q000097:blood; D012259:Ribonuclease, Pancreatic / Q000097:blood; D053802:Tryptases / Q000097:blood*
chemical_list: D016232:Endothelins; D010982:Platelet-Derived Growth Factor; D019009:Proto-Oncogene Proteins c-kit; C046366:angiogenin; D012259:Ribonuclease, Pancreatic; D053802:Tryptases