title: Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia.
abstract: Worldwide, preeclampsia is a significant health risk to both pregnant women and their unborn children. Despite scientific advances, the exact pathogenesis of preeclampsia is not yet fully understood. Meanwhile, the incidence of preeclampsia is expected to increase. A series of potential etiologies for preeclampsia has been identified, including endothelial dysfunction, immunological dysregulation and trophoblastic invasion. In this literature review, we have critically reviewed existing literature regarding the research findings that link the role of vitamin D to the pathogenesis and immunoregulation of preeclampsia. The relationship of vitamin D with the suspected etiologies of preeclampsia underscores its clinical potential in the diagnosis and treatment of preeclampsia.
authors.affiliation: Center for Clinical & Translational Science, Creighton University School of Medicine, Omaha, NE, USA.
authors.forename: Tyler A
authors.initials: TA
authors.lastname: Smith
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Kirkpatrick
authors.forename: Oormila
authors.initials: O
authors.lastname: Kovilam
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Agrawal
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017410:Practice Guidelines as Topic; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D011247:Pregnancy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014807:Vitamin D / Q000276:immunology* / Q000494:pharmacology; D014808:Vitamin D Deficiency / Q000276:immunology*; D014815:Vitamins / Q000276:immunology / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014815:Vitamins; D014807:Vitamin D; D001241:Aspirin
keywords: cathelicidin; endothelial dysfunction; immunomodulation; preeclampsia; vitamin D