title: A surface acoustic wave sensor functionalized with a polypyrrole molecularly imprinted polymer for selective dopamine detection.
abstract: A surface acoustic wave sensor operating at 104 MHz and functionalized with a polypyrrole molecularly imprinted polymer has been designed for selective detection of dopamine (DA). Optimization of pyrrole/DA ratio, polymerization and immersion times permitted to obtain a highly selective sensor, which has a sensitivity of 0.55°/mM (≈ 550 Hz/mM) and a detection limit of ≈ 10 nM. Morphology and related roughness parameters of molecularly imprinted polymer surfaces, before and after extraction of DA, as well as that of the non imprinted polymer were characterized by atomic force microscopy. The developed chemosensor selectively recognized dopamine over the structurally similar compound 4-hydroxyphenethylamine (referred as tyramine), or ascorbic acid,which co-exists with DA in body fluids at a much higher concentration. Selectivity tests were also carried out with dihydroxybenzene, for which an unexpected phase variation of order of 75% of the DA one was observed. Quantum chemical calculations, based on the density functional theory, were carried out to determine the nature of interactions between each analyte and the PPy matrix and the DA imprinted PPy polypyrrole sensing layer in order to account for the important phase variation observed during dihydroxybenzene injection.
authors.affiliation: Laboratoire d'Electrochimie et Matériaux, Université Sétif -1, 19000, Algeria.
authors.forename: Naima
authors.initials: N
authors.lastname: Maouche
authors.affiliation: Laboratoire Méthodes et Techniques d'Analyse, Institut National de Recherche et d'Analyse Physico-chimique, BiotechPole Sidi-Thabet, 2020, Ariana, Tunisia.
authors.forename: Nadia
authors.initials: N
authors.lastname: Ktari
authors.affiliation: Université Paris Diderot, Sorbonne Cité, ITODYS, UMR 7086 CNRS, 15 rue Jean Antoine de Baïf, 75205, Paris, Cedex13, France.
authors.forename: Idriss
authors.initials: I
authors.lastname: Bakas
authors.affiliation: SATIE, UMR 8029, CNRS, ENS-Cachan, Cnam, 292 rue Saint Martin, 75003, Paris, France.
authors.forename: Najla
authors.initials: N
authors.lastname: Fourati
authors.affiliation: SATIE, UMR 8029, CNRS, ENS-Cachan, Cnam, 292 rue Saint Martin, 75003, Paris, France.
authors.forename: Chouki
authors.initials: C
authors.lastname: Zerrouki
authors.affiliation: Université Paris Diderot, Sorbonne Cité, ITODYS, UMR 7086 CNRS, 15 rue Jean Antoine de Baïf, 75205, Paris, Cedex13, France.
authors.forename: Mahamadou
authors.initials: M
authors.lastname: Seydou
authors.affiliation: Université Paris Diderot, Sorbonne Cité, ITODYS, UMR 7086 CNRS, 15 rue Jean Antoine de Baïf, 75205, Paris, Cedex13, France.
authors.forename: François
authors.initials: F
authors.lastname: Maurel
authors.affiliation: Université Paris Diderot, Sorbonne Cité, ITODYS, UMR 7086 CNRS, 15 rue Jean Antoine de Baïf, 75205, Paris, Cedex13, France.|Université Paris Est, ICMPE, SPC, PoPI team, UPEC, 2-8 rue Henri Dunant, 94320, Thiais, France.
authors.forename: Mohammed Mehdi
authors.initials: MM
authors.lastname: Chehimi
mesh_terms: D004298:Dopamine / Q000737:chemistry*; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole; D004298:Dopamine
keywords: DFT calculations; atomic force microscopy (AFM); dopamine; molecularly Imprinted Polymer (MIP); surface acoustic wave (SAW) sensor