title: Selenofuranoside Ameliorates Memory Loss in Alzheimer-Like Sporadic Dementia: AChE Activity, Oxidative Stress, and Inflammation Involvement.
abstract: Alzheimer's disease (AD) is becoming more common due to the increase in life expectancy. This study evaluated the effect of selenofuranoside (Se) in an Alzheimer-like sporadic dementia animal model. Male mice were divided into 4 groups: control, Aβ, Se, and Aβ + Se. Single administration of Aβ peptide (fragments 25-35; 3 nmol/3 μL) or distilled water was administered via intracerebroventricular (i.c.v.) injection. Selenofuranoside (5 mg/kg) or vehicle (canola oil) was administered orally 30 min before Aβ and for 7 subsequent days. Memory was tested through the Morris water maze (MWM) and step-down passive-avoidance (SDPA) tests. Antioxidant defenses along with reactive species (RS) were assessed. Inflammatory cytokines levels and AChE activity were measured. SOD activity was inhibited in the Aβ group whereas RS were increased. AChE activity, GSH, and IL-6 levels were increased in the Aβ group. These changes were reflected in impaired cognition and memory loss, observed in both behavioral tests. Se compound was able to protect against memory loss in mice in both behavioral tests. SOD and AChE activities as well as RS and IL-6 levels were also protected by Se administration. Therefore, Se is promising for further studies.
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Chiapinotto Spiazzi
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Melina
authors.initials: M
authors.lastname: Bucco Soares
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Aryele
authors.initials: A
authors.lastname: Pinto Izaguirry
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Laura
authors.initials: L
authors.lastname: Musacchio Vargas
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Mariane Magalhães
authors.initials: MM
authors.lastname: Zanchi
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Natasha
authors.initials: N
authors.lastname: Frasson Pavin
authors.affiliation: Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Ferreira Affeldt
authors.affiliation: Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Gonçalves 9500, 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Diogo
authors.initials: D
authors.lastname: Seibert Lüdtke
authors.affiliation: Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (LaftamBio), Universidade Federal do Pampa (UNIPAMPA), Campus Itaqui, 97.650-000 Itaqui, RS, Brazil.
authors.forename: Marina
authors.initials: M
authors.lastname: Prigol
authors.affiliation: Laboratório de Biotecnologia da Reprodução (Biotech), Universidade Federal do Pampa (UNIPAMPA), Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil.
authors.forename: Francielli Weber
authors.initials: FW
authors.lastname: Santos
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007249:Inflammation; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016566:Organoselenium Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects; D010429:Pentoses / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016207:Cytokines; D018696:Neuroprotective Agents; D016566:Organoselenium Compounds; D010429:Pentoses; D010446:Peptide Fragments; D017382:Reactive Oxygen Species; C074636:amyloid beta-protein (25-35); C583913:seleno-furanoside; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D000110:Acetylcholinesterase; D005978:Glutathione