title: Regeneration inducers in limb regeneration.
abstract: Limb regeneration ability, which can be observed in amphibians, has been investigated as a representative phenomenon of organ regeneration. Recently, an alternative experimental system called the accessory limb model was developed to investigate early regulation of amphibian limb regeneration. The accessory limb model contributed to identification of limb regeneration inducers in urodele amphibians. Furthermore, the accessory limb model may be applied to other species to explore universality of regeneration mechanisms. This review aims to connect the insights recently gained to emboss universality of regeneration mechanisms among species. The defined molecules (BMP7 (or2) + FGF2 + FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.
authors.affiliation: Research Core for Interdisciplinary Sciences (RCIS), Okayama University, 3-1-1, Tsushimanaka, kitaku, Okayama, 700-8530, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Satoh
authors.affiliation: Research Core for Interdisciplinary Sciences (RCIS), Okayama University, 3-1-1, Tsushimanaka, kitaku, Okayama, 700-8530, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Mitogawa
authors.affiliation: Research Core for Interdisciplinary Sciences (RCIS), Okayama University, 3-1-1, Tsushimanaka, kitaku, Okayama, 700-8530, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Makanae
mesh_terms: D000558:Ambystoma mexicanum / Q000502:physiology; D000663:Amphibians / Q000502:physiology; D000818:Animals; D055419:Bone Morphogenetic Protein 7 / Q000494:pharmacology*; D005121:Extremities / Q000254:growth & development / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D051524:Fibroblast Growth Factor 8 / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology; D014981:Xenopus / Q000502:physiology
chemical_list: D055419:Bone Morphogenetic Protein 7; D016222:Fibroblast Growth Factor 2; D051524:Fibroblast Growth Factor 8
keywords: Xenopus; accessory limb model; axolotl; blastema; limb regeneration