title: Optimization of Surface Coating on Small Pd Nanosheets for in Vivo near-Infrared Photothermal Therapy of Tumor.
abstract: Palladium nanosheets with strong near-infrared absorption have been recently demonstrated as promising photothermal agents for photothermal therapy (PTT) of cancers. However, systematic assessments of their potential risks and impacts to biological systems have not been fully explored yet. In this work, we carefully investigate how surface coatings affect the in vivo behaviors of small Pd nanosheets (Pd NSs). Several biocompatible molecules such as carboxymethyl chitosan (CMC), PEG-NH2, PEG-SH, and dihydrolipoic acid-zwitterion (DHLA-ZW) were used to coat Pd NSs. The blood circulation half-lives, biodistribution, potential toxicity, clearance, and photothermal effect of different surface-coated Pd NSs in mice after intravenous injection were compared. PEG-SH-coated Pd NSs (Pd-HS-PEG) were found to have ultralong blood circulation half-life and show high uptake in the tumor. We then carry out the in vivo photothermal therapeutic studies on the Pd-HS-PEG conjugate and revealed its outstanding efficacy in in vivo photothermal therapy of cancers. Our results highlight the importance of surface coatings to the in vivo behaviors of nanomaterials and can provide guidelines to the future design of Pd NSs bioconjugates for other in vivo applications.
authors.affiliation: †State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China.|‡Research Center of Biomedical Engineering, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Saige
authors.initials: S
authors.lastname: Shi
authors.affiliation: †State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Yizhuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: †State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Chen
authors.affiliation: ‡Research Center of Biomedical Engineering, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Weng
authors.affiliation: †State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China.
authors.forename: Nanfeng
authors.initials: N
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D048271:Chitosan; D005260:Female; D051379:Mice; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000473:pathology / Q000628:therapy; D010165:Palladium / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013817:Thermography; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D011092:Polyethylene Glycols; D010165:Palladium; D048271:Chitosan
keywords: in vivo behaviors; nanosheet; palladium; photothermal therapy; surface coating