title: Changes in endolymphatic hydrops in patients with Ménière's disease treated conservatively for more than 1 year.
abstract: CONCLUSIONS
  This study revealed that endolymphatic hydrops (EH) reduced in some cases with Ménière's disease (MD) treated conservatively. It appears that the EH reduction was associated with improvement of the clinical symptoms.
  
  
  OBJECTIVE
  The relationship between the degree of EH and clinical symptoms is not clear at present. The purpose of the present study was to investigate the time course of the relationship in patients with MD treated conservatively.
  
  
  METHODS
  Twelve patients with MD treated conservatively for more than 1 year in a university hospital.
  
  
  METHODS
  Twenty ears of 12 patients with MD treated conservatively were evaluated. The presence or absence of vertigo, tinnitus and ear fullness was confirmed when magnetic resonance imaging (MRI) was performed. Using a 3 T MRI scanner, three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) MRI was performed 2 or 3 times 24 hours after intra-tympanic gadolinium injection or 4 hours after intravenous gadolinium injection.
  
  
  RESULTS
  In the three ears in which the symptoms alleviated, EH was reduced in two ears, but EH was reduced in only one of 17 ears in which the symptoms did not alleviate. The Fisher exact test revealed that EH reduction occurred more frequently in ears with alleviation of the symptoms (p < 0.05).
authors.affiliation: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Suga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kato
authors.forename: Tadao
authors.initials: T
authors.lastname: Yoshida
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishio
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nakada
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D007758:Ear, Inner / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D013997:Time Factors; D014012:Tinnitus / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D014717:Vertigo / Q000209:etiology / Q000473:pathology
keywords: Ear fullness; magnetic resonance imaging; tinnitus; vertigo