title: Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates.
abstract: B-cell acute lymphoblastic leukemia (B-ALL) is a serious public health problem in the pediatric population worldwide, contributing to 85% of deaths from childhood cancers. Understanding the biology of the disease is crucial for its clinical management and the development of therapeutic strategies. In line with that observed in other malignancies, chronic inflammation may contribute to a tumor microenvironment resulting in the damage of normal processes, concomitant to development and maintenance of neoplastic cells. We report here that hematopoietic cells from bone marrow B-ALL have the ability to produce proinflammatory and growth factors, including TNFα, IL-1β, IL-12, and GM-CSF that stimulate proliferation and differentiation of normal stem and progenitor cells. Our findings suggest an apparently distinct CD13(+)CD33(+) population of leukemic cells contributing to a proinflammatory microenvironment that may be detrimental to long-term normal hematopoiesis within B-ALL bone marrow.
authors.affiliation: "Federico Gómez" Children's Hospital, 06720 Mexico City, DF, Mexico ; Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico ; Clinical Biochemistry Program, National Autonomous University of Mexico, 04510 Mexico City, DF, Mexico.
authors.forename: Armando
authors.initials: A
authors.lastname: Vilchis-Ordoñez
authors.affiliation: Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico ; Molecular Biomedicine Department, CINVESTAV, 07360 Mexico City, DF, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Contreras-Quiroz
authors.affiliation: Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico.
authors.forename: Eduardo
authors.identifier: 0000-0001-5939-8031
authors.initials: E
authors.lastname: Vadillo
authors.affiliation: "Federico Gómez" Children's Hospital, 06720 Mexico City, DF, Mexico.
authors.forename: Elisa
authors.initials: E
authors.lastname: Dorantes-Acosta
authors.affiliation: "Federico Gómez" Children's Hospital, 06720 Mexico City, DF, Mexico.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Reyes-López
authors.affiliation: UMAE "Dr. Victorio de la Fuente Narvaéz", Mexican Institute for Social Security, 07760 Mexico City, DF, Mexico.
authors.forename: Henry Martin
authors.initials: HM
authors.lastname: Quintela-Nuñez del Prado
authors.affiliation: UMAE "Dr. Victorio de la Fuente Narvaéz", Mexican Institute for Social Security, 07760 Mexico City, DF, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Venegas-Vázquez
authors.affiliation: Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico.
authors.forename: Hector
authors.initials: H
authors.lastname: Mayani
authors.affiliation: Molecular Biomedicine Department, CINVESTAV, 07360 Mexico City, DF, Mexico.
authors.forename: Vianney
authors.initials: V
authors.lastname: Ortiz-Navarrete
authors.affiliation: "Federico Gómez" Children's Hospital, 06720 Mexico City, DF, Mexico.
authors.forename: Briceida
authors.initials: B
authors.lastname: López-Martínez
authors.affiliation: Oncology Research Unit, Oncology Hospital, Mexican Institute for Social Security, Avenida Cuauhtemoc 330, Colonia Doctores, 06720 Mexico City, DF, Mexico.
authors.forename: Rosana
authors.initials: R
authors.lastname: Pelayo
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D002648:Child; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology; D018664:Interleukin-12 / Q000096:biosynthesis; D053583:Interleukin-1beta / Q000096:biosynthesis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D053583:Interleukin-1beta; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D016178:Granulocyte-Macrophage Colony-Stimulating Factor