title: Age-related testosterone decline is due to waning of both testicular and hypothalamic-pituitary function.
abstract: Hypogonadism is a condition in which the endogenous secretion of testosterone is either insufficient or inadequate to maintain serum testosterone levels within normal range, and may manifest as a variety of signs and symptoms. Age-related hypogonadism is due to a combination of primary hypogonadism (testicular failure) and secondary hypogonadism (hypothalamic-pituitary axis failure). This review provides insight into the mechanisms resulting in the multifactorial nature of acquired androgen-deficiency, and outlines the current controversy regarding testosterone-replacement therapy in aging males.
authors.affiliation: a Department of Urology , New York Presbyterian Hospital, Weill Cornell Medical College , New York , NY , USA and.
authors.forename: Ron
authors.initials: R
authors.lastname: Golan
authors.affiliation: b Department of Urology , Baylor College of Medicine , Houston , TX , USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Scovell
authors.affiliation: b Department of Urology , Baylor College of Medicine , Houston , TX , USA.
authors.forename: Ranjith
authors.initials: R
authors.lastname: Ramasamy
mesh_terms: D000375:Aging / Q000502:physiology*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone
keywords: Aging; hypogonadism; late-onset hypogonadism; testosterone