title: Sphingolipids in cardiovascular diseases and metabolic disorders.
abstract: Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle diseases such as myocardial infarction, hypertension, stroke, diabetes mellitus type 2 and obesity. Some studies suggest that sphingolipids are important factors in cellular signal transduction. They serve as biologically active components of cell membrane and are involved in many processes such as proliferation, maturation and apoptosis. Recently, ceramide and sphingosine-1-phosphate have become the target of many investigations. Ceramide is generated in three metabolic pathways and many factors induce its production as a cellular stress response. Ceramide has proapoptotic properties and acts as a precursor for many other sphingolipids. Sphingosine-1-phosphate is a ceramide derivative, acting antiapoptotically and mitogenically and it is importantly involved in cardioprotection. Further research on the involvement of sphingolipids in cellular pathophysiology may improve the prevention and therapy of lifestyle diseases.
authors.affiliation: Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, First Faculty of Medicine, Medical University of Warsaw, Banacha 1b, 02-097, Warsaw, Poland. sonia.borodzicz@onet.pl.|1st Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland. sonia.borodzicz@onet.pl.
authors.forename: Sonia
authors.initials: S
authors.lastname: Borodzicz
authors.affiliation: Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, First Faculty of Medicine, Medical University of Warsaw, Banacha 1b, 02-097, Warsaw, Poland. katarzyna.czarzasta@wum.edu.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Czarzasta
authors.affiliation: Department of Heart Failure and Cardiac Rehabilitation of the Chair and Department of Cardiology, Hypertension and Internal Diseases, Second Faculty of Medicine, Medical University of Warsaw, Kondratowicza 8, 03-242, Warsaw, Poland. marek.kuch@wum.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Kuch
authors.affiliation: Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, First Faculty of Medicine, Medical University of Warsaw, Banacha 1b, 02-097, Warsaw, Poland. agnieszka.cudnoch@wum.edu.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Cudnoch-Jedrzejewska
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism*; D013107:Sphingolipids / Q000378:metabolism*
chemical_list: D013107:Sphingolipids