title: Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation.
abstract: Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute School of Medicine, University of Queensland, Brisbane, Australia.
authors.forename: Archana
authors.initials: A
authors.lastname: Panikkar
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Corey
authors.initials: C
authors.lastname: Smith
authors.affiliation: School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hislop
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Nick
authors.initials: N
authors.lastname: Tellam
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Vijayendra
authors.initials: V
authors.lastname: Dasari
authors.affiliation: Department of Laboratory Medicine and Pathology.
authors.forename: Kristin A
authors.initials: KA
authors.lastname: Hogquist
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Michelle
authors.initials: M
authors.lastname: Wykes
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Denis J
authors.initials: DJ
authors.lastname: Moss
authors.affiliation: School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, United Kingdom.
authors.forename: Alan
authors.initials: A
authors.lastname: Rickinson
authors.affiliation: Department of Laboratory Medicine and Pathology Department of Pediatrics, University of Minnesota Medical School, Minneapolis.
authors.forename: Henry H
authors.initials: HH
authors.lastname: Balfour
authors.affiliation: QIMR Centre for Immunotherapy and Vaccine Development, Tumour Immunology Laboratory, QIMR Berghofer Medical Research Institute.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Khanna
mesh_terms: D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007244:Infectious Mononucleosis / Q000276:immunology / Q000473:pathology*; D016753:Interleukin-10 / Q000097:blood* / Q000378:metabolism; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: acute infection; anti-viral immunity; cytokines; dendritic cells; herpesvirus; immune dysregulation; immune regulation; virus