title: Antifungal prophylaxis with anidulafungin to minimize drug interactions with an antiepileptic treatment in a hematopoietic stem cell transplant recipient.
abstract: OBJECTIVE
  Invasive fungal infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). This provides a clear rationale for antifungal prophylaxis in this population. A concern is the potential for drug interactions, given that most of antifungals are metabolized through the P450 cytochrome system.
  
  
  METHODS
  We present a case of a 33-year-old woman, with a past history of high-risk epilepsy, who underwent allogeneic HSCT for a myelodysplastic syndrome. Anidulafungin was successfully used as antifungal prophylaxis to minimize drug interactions with her antiepileptic treatment.
  
  
  CONCLUSIONS
  This is the first reported case of antifungal prophylaxis with this echinocandin in HSCT. Anidulafungin may be an option in transplant recipients with multiple risk factors for drug interactions.
authors.affiliation: Haematology Department, Hospital San Pedro, Logroño, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Feliu
authors.affiliation: Infectious Diseases Division and Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Del Pozo
authors.affiliation: Pharmacology Department, Clinica Universidad de Navarra, Pamplona, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Azanza
authors.affiliation: Haematology Department, Hospital San Pedro, Logroño, Spain.
authors.forename: R
authors.initials: R
authors.lastname: García-Muñoz
authors.affiliation: Haematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Zabalza
authors.affiliation: Haematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gorosquieta
authors.affiliation: Haematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Equiza
authors.affiliation: Haematology Department, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Olavarría
keywords: anidulafungin; antifungal prophylaxis; drug interactions; hematopoietic stem cell transplantation