title: [A short report: Blood pressure variability and outcomes in chronic kidney disease long survivors patients].
abstract: In the last decade blood pressure variability (BPV) measured during a follow-up of hypertensive chronic kidney disease (CKD) patients or hemodialysis patients has received a even major attention. The aim of our study is to study the relationship between BPV and mortality and/or dialysis initiation in long survivors CKD patients. We conducted a historical prospective observational multicentric study in 131 subjects still alive at 31st December 2010, when ended a our previous study published on Nephrology Dialysis Transplantation. Long Survivors patients were younger (p<0.01) and had a lower BPV compared to the original population. Moreover, they had creatinine levels significantly lower (p<0.019), so as lower phosphate levels (p<0.05) and higher hemoglobin (p<0.05). During a mean follow-up of 80.713.4 months, 63 patients (48.1%) died and 49 of them (37.4%) started dialysis treatment. In this group, 28 patients died after dialysis initiation. Kaplan-Meier curves showed a significant association between BPV and cardiovascular mortality risk (Hazard Ratio [HR]: 1.061; 95% Confidence Interval [CI]: 1.0351.093; p = 0.001) and between BPV and renal death (HR 1.049; 95% CI: 10121.74; P = 0.001). In conclusions, our data in long survivors patients showed that BPV can be used for mortality cardiovascular and renal death risk stratification in CKD patients.
authors.forename: Biagio Raffaele
authors.initials: BR
authors.lastname: Di Iorio
authors.forename: Lucia
authors.initials: L
authors.lastname: Di Micco
authors.forename: Antonella
authors.initials: A
authors.lastname: De Blasio
authors.forename: Roberto
authors.initials: R
authors.lastname: Rubino
authors.forename: Pasquale
authors.initials: P
authors.lastname: Guastaferro
mesh_terms: D000368:Aged; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000401:mortality* / Q000503:physiopathology* / Q000628:therapy; D017741:Survivors; D013997:Time Factors; D016896:Treatment Outcome