title: [Effectiveness of FTA Elute® indicating cartridge in combination with hybrid capture 2 for cervical cancer screening].
abstract: OBJECTIVE
  To evaluate the effectiveness of FTA Elute® Cartridge (GE healthcare, Kent, UK) in combination with hybrid capture 2 (HC2) testing for cervical cancer screening.
  
  
  METHODS
  From May to June 2012, 412 women aged 25 to 65 years in Jiangxi Tonggu were enrolled in the study. We used pathological outcome as the gold standard, and the accuracy of the FTA card in combination with HC2 testing was investigated from both physician- and self-sampling, respectively.
  
  
  RESULTS
  Physician sampling using the FTA card in combination with HC2 testing showed a comparable sensitivity (12/13) with the liquid based medium, but a higher specificity 69.5% (266/383) vs (77.8%, 298/383) (P < 0.001).When self sampling method was used, the sensitivity and specificity of using the FTA card in combination with HC2 testing with liquid based medium was 10/13 vs 8/13(P = 0.625) and (62.3%, 238/382) vs (75.7%, 289/382) (P < 0.001). The agreement of detection results for HC2 between FTA and liquid-based sampling medium was 86.1% (340/395) and 79.5% (314/395). For physician-collected samples used for HC2 testing to detect CIN2+, the accuracy of the FTA card was superior to that of the liquid-based medium (area under the receiver operating characteristic curve (AUC) = 0.898, 95%CI:0.838-0.958).
  
  
  CONCLUSIONS
  FTA Elute® cartridge in combination with HC2 testing is a promising method of specimen transport for cervical cancer screening programs with a good precision.With further optimization, it could become an effective method for cervical cancer screening in various economic levels of areas.
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Shaoming
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Shangying
authors.initials: S
authors.lastname: Hu
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Fanghui
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Email: qiaoy@cicams.ac.cn.
authors.forename: Youlin
authors.initials: Y
authors.lastname: Qiao
mesh_terms: D000328:Adult; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013048:Specimen Handling; D002583:Uterine Cervical Neoplasms