title: Severe hepatoxicity caused by aspirin overdose: a case report.
abstract: We report here the rare case of a 61-year-old man with multiple organ dysfunction caused by an aspirin overdose (4 g orally). The patient presented with a fever that reached 39.2 °C, a peptic ulcer, and massive upper gastrointestinal bleeding. His blood test results were as follows: white blood cell count, 1.8 × 10(9)/L; absolute lymphocytes, 0.4 × 10(9)/L; absolute neutrophils, 1.2 × 10(9)/L; and electrolyte disturbances. A computed tomography (CT) scan showed evidence of bilateral inferior pulmonary infection and acute pancreatitis. Thick dark bile with visible floccule was drawn via a percutaneous transhepatic cholangiodrainage (PTCD). Klebsiella pneumoniae was detected in microbiological bile tests. Two years later, the patient died of chronic liver failure.
authors.affiliation: Department of Nursing, School of Medicine, Shihezi University, Shihezi, 832002, China.
authors.forename: Zhuping
authors.initials: Z
authors.lastname: Cao
authors.forename: Shiqi
authors.initials: S
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Niu
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
mesh_terms: D001241:Aspirin / Q000008:administration & dosage* / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D062787:Drug Overdose / Q000150:complications*; D006801:Humans; D017093:Liver Failure / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D001241:Aspirin