title: Living on pyrrolic foundations - Advances in natural and artificial bioactive pyrrole derivatives.
abstract: Pyrrole, a simple heterocyclic system, is an important building block for numerous biologically active compounds both natural and synthetic in origin, which boast an immense array of qualities, baleful and beneficial alike. The latter have given rise to a bountiful variety of pyrrole-based drugs, with many more being designed, developed and applied each year, as evidenced by the amount of entries in the Cambridge Structural Database skyrocketing from about six hundred in 2004 to more than a thousand over the course of the last decade. Particularly important in light of the ever-encroaching menace of drug-resistant bacteria, the vast progress in the field necessitates a sound organisational framework and summary - a task, to which we contribute this summary and checklist of the most recent developments, indicating the classes of compounds, which have attracted the most significant research attention.
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 M. Curie-Skłodowskiej Street, 41- 819 Zabrze, Poland. Electronic address: anna.domagala@cmpw-pan.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Domagala
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 9 Marcina Strzody Street, 44-100 Gliwice, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jarosz
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 M. Curie-Skłodowskiej Street, 41- 819 Zabrze, Poland; Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, 9 Marcina Strzody Street, 44-100 Gliwice, Poland.
authors.forename: Mieczyslaw
authors.initials: M
authors.lastname: Lapkowski
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D011758:Pyrroles
keywords: Alkaloids; Biological activity; Biosynthesis; Hybridisation; Pyrrole