title: Maternal high-fat diet is associated with impaired fetal lung development.
abstract: Maternal nutrition has a profound long-term impact on infant health. Poor maternal nutrition influences placental development and fetal growth, resulting in low birth weight, which is strongly associated with the risk of developing chronic diseases, including heart disease, hypertension, asthma, and type 2 diabetes, later in life. Few studies have delineated the mechanisms by which maternal nutrition affects fetal lung development. Here, we report that maternal exposure to a diet high in fat (HFD) causes placental inflammation, resulting in placental insufficiency, fetal growth restriction (FGR), and inhibition of fetal lung development. Notably, pre- and postnatal exposure to maternal HFD also results in persistent alveolar simplification in the postnatal period. Our novel findings provide a strong association between maternal diet and fetal lung development.
authors.affiliation: Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;
authors.forename: Reina S
authors.initials: RS
authors.lastname: Mayor
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Katelyn E
authors.initials: KE
authors.lastname: Finch
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Jordan
authors.initials: J
authors.lastname: Zehr
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Eugenia
authors.initials: E
authors.lastname: Morselli
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Neinast
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Frank
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Hahner
authors.affiliation: Department of Pathology and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Jason
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathology and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rakheja
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and.
authors.forename: Biff F
authors.initials: BF
authors.lastname: Palmer
authors.affiliation: Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;
authors.forename: Charles R
authors.initials: CR
authors.lastname: Rosenfeld
authors.affiliation: Center for Pulmonary and Vascular Biology and Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas;
authors.forename: Rashmin C
authors.initials: RC
authors.lastname: Savani
authors.affiliation: Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and deborah.clegg@cshs.org.
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Clegg
mesh_terms: D000818:Animals; D001786:Blood Glucose; D059305:Diet, High-Fat / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology*; D007249:Inflammation / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008168:Lung / Q000196:embryology* / Q000254:growth & development / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: chorioamnionitis; fetal growth restriction; intrauterine growth restriction; placental inflammation; respiratory distress syndrome