title: Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring.
abstract: OBJECTIVE
  To evaluate the effects of gestational subclinical hypothyroidism (SCH) on early neurodevelopment of offspring.
  
  
  METHODS
  A prospective study included 106 infants born to mothers with gestational SCH and 106 infants born to mothers who were euthyroid during pregnancy. The neurodevelopment of 12 to 24-month-old infants was assessed and compared using the Gesell developmental test (revised version).
  
  
  RESULTS
  Infants born to mothers with gestational SCH and those born to euthyroid mothers had similar scores on the Gesell development test. No correlations were observed between maternal TSH concentration and Gesell developmental test scores of offspring. Infants born to mothers who had gestational SCH during the first trimester specifically and those born to euthyroid mothers had similar scores on the Gesell development test. No significant correlations were detected between maternal TSH concentration during the first trimester and offspring neurodevelopment.
  
  
  CONCLUSIONS
  No detectable neurodevelopment deficit was observed in offspring up to 24 months old from mothers who had gestational SCH.
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: L-M
authors.initials: LM
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Wenzhou People's Hospital, Wenzhou, China.
authors.forename: Q-S
authors.initials: QS
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.
authors.forename: G-X
authors.initials: GX
authors.lastname: Jin
authors.affiliation: Department of Endocrinology, Jining First People's Hospital, Jining, China.
authors.forename: G-X
authors.initials: GX
authors.lastname: Si
authors.affiliation: ICU, Taizhou First People's Hospital, Taizhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: E-L
authors.initials: EL
authors.lastname: Ye
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: L-Q
authors.initials: LQ
authors.lastname: Cai
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: M-M
authors.initials: MM
authors.lastname: Peng
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: Z-Z
authors.initials: ZZ
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: L-C
authors.initials: LC
authors.lastname: Yu
authors.affiliation: Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.|Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.|Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Lu
mesh_terms: D000328:Adult; D000067290:Behavior Rating Scale; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D007361:Intelligence Tests; D008137:Longitudinal Studies; D008297:Male; D009420:Nervous System / Q000254:growth & development*; D009483:Neuropsychological Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D011261:Pregnancy Trimester, First / Q000097:blood; D011297:Prenatal Exposure Delayed Effects / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D011446:Prospective Studies; D013223:Statistics as Topic; D013974:Thyroxine / Q000097:blood
chemical_list: D013974:Thyroxine