title: Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma.
abstract: OBJECTIVE
  Factors that predict the prognosis of patients with recurrent or metastatic retroperitoneal leiomyosarcomas after treatment are uncertain.
  
  
  METHODS
  Clinical and pathological data on 22 patients with retroperitoneal leiomyosarcomas who were treated by a multidisciplinary abdominal soft-tissue tumor group were analyzed retrospectively to identify prognostic factors for their progression-free survival (PFS).
  
  
  CONCLUSIONS
  The median PFS in the 22 patients was 9 months. Microvessel density in tumor tissues, which was evaluated via CD34 expression in 16 cases, and the presence of metastasis on admission were both found to be correlated with PFS in a Kaplan-Meier analysis, but not in a multivariate analysis. The multivariate analysis did, however, show that complete resection of tumors and the FNCLCC (Fédération Nationale des Centres de Lutte Contre Le Cancer) disease grade were independent factors predicting PFS.
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Rongyuan
authors.initials: R
authors.lastname: Zhuang
authors.affiliation: Department of Surgery, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Surgery, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Weiqi
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Pathology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yingyong
authors.initials: Y
authors.lastname: Hou
authors.affiliation: Department of Pathology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Ju
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Surgery, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Tianshu
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Zhong Shan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000401:mortality / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies
keywords: FNCLCC grade; microvessel density; prognosis; retroperitoneal leiomyosarcoma; soft tissue sarcoma; treatment