title: CORRELATION BETWEEN THE LIPID PROFILE AND THE IMMUNOLOGICAL CHARACTERISTICS IN THE ELDERLY.
abstract: Some changes in lipid metabolism and immune status occurring at aging are accompanied with development of inflammatory metabolic disorders and age-associated pathologies. It is well-known that permanent stimulation of immune responses may lead to hyperlipidemia that, in its turn, may evoke immune disturbances and affect the auto-inflammation processes. It seems important to explore a mutual relationship between lipid metabolites and immunology markers in order to better manage the age-associated diseases. In Georgian population the study on associations between the lipid metabolism and the immunological parameters might be especially interesting due the specific geo-climate environment and dietary peculiarities of the country. Study involved 250 healthy volunteers at the age of 18-80 years that were tested on the lymphocyte sub-populations (CD3+CD4+, CD3+CD8+, CD4+CD8+, CD4+CD25+FoxP3+) in peripheral blood, as well as on the levels of lipids (Low-and High density lipoproteins, triglycerides and total cholesterol levels. The study revealed statistically significant differences between the under-60 and above-60 age groups by the level of lipids (low density lipoproteins and total cholesterol) and of CD4+CD25+FoxP3+ cell counts in the healthy population of Georgia. Meanwhile, the lipid fractions (low density lipoproteins, triglycerides and total cholesterol) showed statistically reliable positive correlation with CD4+CD8+ cell but negative correlation with CD4+CD25+FoxP3+cell counts.
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: B
authors.initials: B
authors.lastname: Lasareishvili
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: I
authors.initials: I
authors.lastname: Pantsulaia
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: M
authors.initials: M
authors.lastname: Iobadze
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Kukuladze
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Kikodze
authors.affiliation: Institute of Medical Biotechnology, Tbilisi State Medical University, Tbilisi, Georgia.
authors.forename: T
authors.initials: T
authors.lastname: Chikovani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000473:pathology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood / Q000502:physiology; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D016207:Cytokines; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol