title: Is there any association between cognitive status and functional capacity during exacerbation of chronic obstructive pulmonary disease?
abstract: The aim of this study is to screen the cognitive function during exacerbation of chronic obstructive pulmonary disease (COPD) and investigate whether there is any association between cognitive function and functional impairment, disease severity, or other clinical parameters. Age and sex-matched 133 subjects with COPD exacerbation, 34 stable COPD subjects, and 34 non-COPD subjects were enrolled in this study. For the purpose of this study, mini-mental state examination (MMSE) and Hospital Anxiety and Depression scale were performed. Six-minute walk distance (6MWD) was recorded, and BODE index was calculated. COPD subjects with exacerbation had the lowest MMSE scores (p = 0.022). Frequency of subjects with MMSE score lower than 24 is 22.6, 8.8, and 8.8% in the COPD subjects with exacerbation, stable COPD, and non-COPD control subjects, respectively. The COPD subjects with exacerbation who had MMSE scores lower than 24 were older and less educated. Subjects with COPD exacerbation had shorter 6MWD than that of stable COPD and non-COPD subjects. After controlling for the impact of age and educational level on MMSE, there was no association between 6MWD and MMSE scores in subjects with COPD exacerbation. Cognitive impairment is an important comorbidity during COPD exacerbation. Functional capacity is also lower in exacerbation. However, no association was found between cognitive impairment and functional capacity during exacerbation.
authors.affiliation: Koc University School of Medicine, Department of Physical Medicine and Rehabilitation, Topkapı, Istanbul, Turkey ozdenozyemisci@yahoo.com.
authors.forename: Ozden
authors.initials: O
authors.lastname: Ozyemisci-Taskiran
authors.affiliation: Atatürk Training and Research Hospital, Physical Medicine and Rehabilitation Unit, Ankara, Turkey.
authors.forename: Sinem Ozcan
authors.initials: SO
authors.lastname: Bozkurt
authors.affiliation: Gazi University Faculty of Medicine, Department of Pulmonary Medicine, Ankara, Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Kokturk
authors.affiliation: Gazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.
authors.forename: Gulcin Kaymak
authors.initials: GK
authors.lastname: Karatas
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003071:Cognition / Q000502:physiology*; D018450:Disease Progression; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000523:psychology*; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: Chronic obstructive pulmonary disease; disease exacerbation; lung function tests; mild cognitive impairment