title: Parma consensus statement on metabolic disruptors.
abstract: A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to the role of environmental chemicals, referred to as "metabolic disruptors", in obesity and metabolic syndrome with special attention to recent discoveries from animal model and epidemiology studies; 2. Identify conclusions that could be drawn with confidence from existing animal and human data; 3. Develop predictions based on current data; and 4. Identify critical knowledge gaps and areas of uncertainty. The consensus statements are intended to aid in expanding understanding of the role of metabolic disruptors in the obesity and metabolic disease epidemics, to move the field forward by assessing the current state of the science and to identify research needs on the role of environmental chemical exposures in these diseases. We propose broadening the definition of obesogens to that of metabolic disruptors, to encompass chemicals that play a role in altered susceptibility to obesity, diabetes and related metabolic disorders including metabolic syndrome.
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. heindelj@niehs.nih.gov.
authors.forename: Jerrold J
authors.initials: JJ
authors.lastname: Heindel
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Vom Saal
authors.affiliation: Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Blumberg
authors.affiliation: Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bovolin
authors.affiliation: Department of Cell Biology and Neurosciences, Insituto Superiore di Sanita, Rome, Italy.
authors.forename: Gemma
authors.initials: G
authors.lastname: Calamandrei
authors.affiliation: Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
authors.forename: Graziano
authors.initials: G
authors.lastname: Ceresini
authors.affiliation: Public Health Institute, Berkeley, CA, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Cohn
authors.affiliation: Interdepartment Center for Environmental Science Research, University of Bologna, Ravenna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Fabbri
authors.affiliation: Department of Neuroscience, University of Parma, Parma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Gioiosa
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kassotis
authors.affiliation: Department of Toxicology and Environmental Health, VU University Amsterdam, Amsterdam, Netherlands.
authors.forename: Juliette
authors.initials: J
authors.lastname: Legler
authors.affiliation: Department of Environmental Toxicology, University of California, Davis, CA, USA.
authors.forename: Michele
authors.initials: M
authors.lastname: La Merrill
authors.affiliation: Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Rizzir
authors.affiliation: Sheba Medical Center and Tel-Aviv University, Tel -Aviv, Israel.
authors.forename: Ronit
authors.initials: R
authors.lastname: Machtinger
authors.affiliation: Instituto Superiore di Sanita, Rome, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.affiliation: School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Mendez
authors.affiliation: Department of Pediatrics, University of Parma, Parma, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Montanini
authors.affiliation: University of Milano-Bicocca, Monza, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Molteni
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, USA.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Nagel
authors.affiliation: Faculty of Medicine, University of Parma, Parma, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Parmigiani
authors.affiliation: Department of Neuroscience and Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Panzica
authors.affiliation: Department of Neuroscience and Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Paterlini
authors.affiliation: Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Pomatto
authors.affiliation: Department of Biology, University of Bergen, Bergen, Norway.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Ruzzin
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sartor
authors.affiliation: Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
authors.forename: Thaddeus T
authors.initials: TT
authors.lastname: Schug
authors.affiliation: Department of Pediatrics, University Hospital, Parma, Italy.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Street
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Suvorov
authors.affiliation: Department of Internal Medicine, University of Parma, Parma, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Volpi
authors.affiliation: Department of Biology, University of Massachusetts, Amherst, MA, USA.
authors.forename: R Thomas
authors.initials: RT
authors.lastname: Zoeller
authors.affiliation: Department of Neuroscience, University of Parma, Parma, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Palanza
mesh_terms: D003226:Congresses as Topic; D003245:Consensus Statements as Topic; D003920:Diabetes Mellitus / Q000139:chemically induced; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D007558:Italy; D024821:Metabolic Syndrome / Q000139:chemically induced; D009765:Obesity / Q000139:chemically induced
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances