title: Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.
abstract: Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, and other causes. So far, only a few cases of IgA bullous dermatosis coexisting with IgA nephropathy have been reported. A 64-year-old female receiving intravenous ceftriaxone and metronidazole for liver abscess had purpuric macules and papules on her extremities. One week later, she had generalized edema and skin rash with bullae and was diagnosed with concurrent linear IgA dermatosis and IgA nephropathy. After steroid treatment, the skin lesion subsided within two weeks, and kidney function slowly returned to normal. As both diseases occurred after a common possible cause, we predict their pathogeneses are associated.
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Ji Seok
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Misoo
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Nam
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Byung Cheol
authors.initials: BC
authors.lastname: Park
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Myung Hwa
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
authors.forename: Seung Phil
authors.initials: SP
authors.lastname: Hong
keywords: Drug eruptions; Glomerulonephritis; Immunoglobulin A; Linear IgA bullous dermatosis