title: Effects of chrondro-osseous regenerative compound associated with local treatments in the regeneration of bone defects around implants: an in vivo study.
abstract: OBJECTIVE
  The objective of this study was to evaluate the use of a chondroitin sulfate and glycosaminoglycan-based chrondro-osseous regenerative compound (CORC) with different local treatments for bone regeneration in dehiscence defects. The hypothesis is that CORC can enhance bone regeneration with or without local treatment.
  
  
  METHODS
  Twelve mongrel dogs received four implants each in the right femur. Bony defects (4-mm height × 4-mm width) were created and locally treated as follows: reabsorbable membrane (Mem), hidroxyapatite (HA), hydroxyapatite covered with membrane (HA+Mem), or left untreated (Con). Six dogs received one pill of the CORC daily. After 90 days, the implants were retrieved, and histological sections were obtained. The height of bone formation, new bone area (NBA), and bone to implant contact (BIC) within the threads were evaluated to assess the effects of the use of CORC to promote bone regeneration in the defects. Results were statistically analyzed using ANOVA and Tukey's test with 5% significance level.
  
  
  RESULTS
  CORC was not capable to increase the height of bone formation, NBA, and BIC. When the local treatments were analyzed regardless of the use of CORC, HA+Mem and Ha presented higher BIC and height of bone formation. There was no difference for NBA among the local treatments.
  
  
  CONCLUSIONS
  The hypothesis was rejected since the use of CORC has not increased any of the parameters evaluated.
  
  
  CONCLUSIONS
  Dehiscence-like defects can compromise soft tissue support and result in loss of periodontal health and implants. Hydroxyapatite can induce bone regeneration in the defects created. CORC in the formulation used in this study did not promote further bone regeneration in dehiscence-like defects.
authors.affiliation: University of Passo Fundo, School of Dentistry, Passo Fundo, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Tonetto
authors.affiliation: University of Passo Fundo, School of Dentistry, Passo Fundo, Brazil.
authors.forename: Pablo Walker
authors.initials: PW
authors.lastname: Lago
authors.affiliation: University of Passo Fundo, School of Dentistry, Passo Fundo, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Borba
authors.affiliation: Faculty of Dentistry, Oral Sciences, National University of Singapore, 11 Lower Kent Ridge Road, Singapore, 119083, Singapore. denvr@nus.edu.sg.
authors.forename: Vinícius
authors.identifier: http://orcid.org/0000-0002-9203-7657
authors.initials: V
authors.lastname: Rosa
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D002809:Chondroitin Sulfates / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004285:Dogs; D005269:Femur; D006025:Glycosaminoglycans / Q000494:pharmacology*; D020007:Implants, Experimental; D023421:Models, Animal; D013529:Surgical Wound Dehiscence / Q000188:drug therapy*
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D006025:Glycosaminoglycans; D002809:Chondroitin Sulfates
keywords: Bone formation; Chondroitin sulfate; Glycosaminoglycan; Guided bone regeneration; Hydroxyapatite; Membrane; Titanium