title: Association between MTHFR C677T polymorphism and diabetic nephropathy in the Chinese population: An updated meta-analysis and review.
abstract: To clarify the effects of MTHFR C677T polymorphism on the risk of diabetic nephropathy (DN) in the Chinese population, an updated meta-analysis was performed. Related studies were identified from PubMed, Springer Link, Ovid and Chinese Databases up to 24 February 2015. A total of 15 studies including 1227 DN cases, 586 healthy controls and 1277 diabetes mellitus (DM) controls were involved in this meta-analysis. Overall, a significantly elevated risk of DN was associated with all variants of MTHFR C677T when compared with the healthy group (T vs C, odds ratio (OR) = 2.22, 95% confidence interval (CI) = 1.88-2.61; TT vs CC, OR = 4.22, 95% CI = 3.02-5.90; TT + CT vs CC, OR = 2.62, 95% CI = 2.07-3.31; TT vs CC + CT, OR = 2.81, 95% CI = 2.08-3.81) or DM (T vs C, OR = 1.78, 95% CI = 1.59-2.00; TT vs CC, OR = 2.95, 95% CI = 2.33-3.73; TT + CT vs CC, OR = 1.93, 95% CI = 1.63-2.29; TT vs CC + CT, OR = 2.31, 95% CI = 1.87-2.84). In subgroup analyses stratified by ethnicity and geographic areas, it revealed the significant results in Chinese Han, in North and South China. The risk conferred by MTHFR C677T polymorphism is higher in North China than in South China. This meta-analysis showed that the MTHFR C677T variants may influence DN risk in Chinese, and further studies with gene-gene and gene-environment interactions are required for definite conclusions.
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xiong
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Xiao-Kun
authors.initials: XK
authors.lastname: Lin
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Dan-Ping
authors.initials: DP
authors.lastname: Qin
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Dao-Yuan
authors.initials: DY
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Hu
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Nephrology, Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou, China.
authors.forename: Xiao-Shi
authors.initials: XS
authors.lastname: Zhong
mesh_terms: D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
keywords: diabetic nephropathy; meta-analysis; methylenetetrahydrofolate reductase; polymorphism