title: The immune system as a self-centered network of lymphocytes.
abstract: This essay makes a brief historical and comparative review of selective and network theories of the immune system which is presented as a chemical sensory system with immune and non-immune functions. The ontogeny of immune networks is the result of both positive and negative selection of lymphocytes to self-epitopes that serve as a "template" for the recognition of foreign antigens. The development of immune networks progresses from single individual clones in early ontogeny into complex "information processing networks" in which lymphocytes are linked to inhibitory and stimulatory immune cells. The results of these regulatory interactions modulate immune responses and tolerance.
authors.affiliation: The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Fabio R
authors.initials: FR
authors.lastname: Santori
mesh_terms: D000818:Animals; D015551:Autoimmunity; D060965:Clonal Evolution / Q000276:immunology; D060966:Clonal Selection, Antigen-Mediated / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000502:physiology*; D007109:Immunity; D056747:Immunomodulation; D008214:Lymphocytes / Q000502:physiology*; D017634:Self Tolerance / Q000276:immunology
chemical_list: D000939:Epitopes
keywords: Autoimmunity; B cells; Immune networks; Immunology; Self-peptides; T cells