title: Multifaceted role of prohibitin in cell survival and apoptosis.
abstract: Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis.
authors.affiliation: Department of Respiratory Medicine, Respiratory Disease Research Institute, Second XiangYa Hospital of Central South University, Changsha, 410011, People's Republic of China.
authors.forename: Ya-Ting
authors.initials: YT
authors.lastname: Peng
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Ouyang
authors.forename: Lei
authors.initials: L
authors.lastname: Song
mesh_terms: D021581:Active Transport, Cell Nucleus; D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D000091402:Prohibitins; D011499:Protein Processing, Post-Translational; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000091402:Prohibitins; D012097:Repressor Proteins