title: Low G preconditioning reduces liver injury induced by high +Gz exposure in rats.
abstract: OBJECTIVE
  To investigate the effect of repeated lower +Gz exposure on liver injury induced by high +Gz exposure in rats.
  
  
  METHODS
  Sixty male Wister rats were randomly divided into a blank control group, a low G preconditioning group (LG) (exposed to +4 Gz/5 min per day for 3 d before +10 Gz/5 min exposure), and a +10 Gz/5 min group (10G) (n = 20 in each group). Blood specimens and liver tissue were harvested at 0 h and 6 h after +10 Gz/5 min exposure. Liver function was analyzed by measuring serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, and liver injury was further assessed by histopathological observation. Malondialdehyde (MDA), superoxide dismutase (SOD) and Na(+)-K(+)-ATPase were determined in hepatic tissue.
  
  
  RESULTS
  The group LG had lower ALT, AST, and MDA values at 0 h after exposure than those in group 10G. SOD values and Na(+)-K(+)-ATPase activity in the LG group were higher than in group 10G 0 h post-exposure. Hepatocyte injury was significantly less in group LG than in group 10G on histopathological evaluation.
  
  
  CONCLUSIONS
  It is suggested that repeated low +Gz exposure shows a protective effect on liver injury induced by high +Gz exposure in rats.
authors.affiliation: Bin Shi, Zhi-Qiang Feng, Wen-Bing Li, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, Beijing 100142, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.affiliation: Bin Shi, Zhi-Qiang Feng, Wen-Bing Li, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, Beijing 100142, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Feng
authors.affiliation: Bin Shi, Zhi-Qiang Feng, Wen-Bing Li, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, Beijing 100142, China.
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Li
authors.affiliation: Bin Shi, Zhi-Qiang Feng, Wen-Bing Li, Hong-Yi Zhang, Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital, Beijing 100142, China.
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Zhang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002498:Centrifugation; D019610:Cytoprotection; D004195:Disease Models, Animal; D018470:Gravity, Altered; D018471:Hypergravity; D018472:Hypogravity; D008099:Liver / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014947:Wounds and Injuries / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000254:Sodium-Potassium-Exchanging ATPase
keywords: Animal centrifuge; Liver injury; Positive acceleration (+Gz); Preconditioning; Rat