title: Serologic response after vaccination against influenza (A/H1N1)pdm09 in children with renal disease receiving oral immunosuppressive drugs.
abstract: A limited number of reports are available regarding the effect of the influenza vaccine in pediatric patients receiving steroid and immunosuppressant therapy. The influenza A(H1N1)pdm09 vaccine was administered to 15 children with renal disease who were receiving steroid and immunosuppressant therapy (treatment group) and 23 children with who were not receiving these drugs (non-treatment group). Titer transition of the hemagglutination inhibition antibody was compared between the 2 groups immediately before vaccination and 4 weeks and 6 months after vaccination. Multivariate analysis showed a significant correlation between geometric mean titer, SCR, and SPR with age, while no correlation was observed between treatment with immunosuppressant therapy and efficacy. No serious adverse reactions occurred after vaccination. This strain is not present in existing influenza vaccines, and A(H1N1)pdm09HA vaccination was administered alone in 2009. The children in this study had not previously been exposed to this strain. Therefore, we evaluated the effect of the A(H1N1)pdm09HA vaccine without the effects of vaccination or past infection with A(H1N1)pdm09HA or A(H3N2) vaccination in the previous year.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University Medical Center, Japan. Electronic address: tanaka_seiji@kurume-u.ac.jp.
authors.forename: Seiji
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Department of Pediatrics and Child Health, Kurume University Medical Center, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Saikusa
authors.affiliation: Department of Pediatrics and Child Health, Kurume University Medical Center, Japan.
authors.forename: Yuno
authors.initials: Y
authors.lastname: Katafuchi
authors.affiliation: Department of Pediatrics and Child Health, Kurume University Medical Center, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ushijima
authors.affiliation: Department of Pediatrics and Child Health, Kurume University, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohtsu
authors.affiliation: Department of Pediatrics and Child Health, Kurume University, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Tsumura
authors.affiliation: Department of Pediatrics and Child Health, Kurume University Medical Center, Japan.
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D007674:Kidney Diseases / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007166:Immunosuppressive Agents; D007252:Influenza Vaccines
keywords: Children; Immunogenicity; Immunosuppressive drugs; Influenza vaccination; Renal disease