title: Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).
abstract: We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services.
authors.affiliation: J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Defechereux
authors.affiliation: J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
authors.forename: Megha
authors.initials: M
authors.lastname: Mehrotra
authors.affiliation: Bridge HIV, San Francisco Department of Public Health, San Francisco, CA, USA.|University of California, San Francisco, CA, USA.
authors.forename: Albert Y
authors.initials: AY
authors.lastname: Liu
authors.affiliation: J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA.
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: McMahan
authors.affiliation: University of California, San Francisco, CA, USA.
authors.forename: David V
authors.initials: DV
authors.lastname: Glidden
authors.affiliation: Fenway Community Health, Boston, MA, USA.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
authors.affiliation: Investigaciones Medicas en Salud, Lima, Peru.
authors.forename: Lorena
authors.initials: L
authors.lastname: Vargas
authors.affiliation: School of Public Health, University of Michigan, Ann Arbor, MI, USA.
authors.forename: K Rivet
authors.initials: KR
authors.lastname: Amico
authors.affiliation: Desmond Tutu HIV Foundation, University of Cape Town, Cape Town, South Africa.
authors.forename: Piotr
authors.initials: P
authors.lastname: Chodacki
authors.affiliation: Fundacion Ecuatoriana Equidad, Guayaquil, Ecuador.
authors.forename: Telmo
authors.initials: T
authors.lastname: Fernandez
authors.affiliation: University of Sao Paulo Medical School, Sao Paulo, Brazil.
authors.forename: Vivian I
authors.initials: VI
authors.lastname: Avelino-Silva
authors.affiliation: National Institutes of Health, Bethesda, MD, USA.
authors.forename: David
authors.initials: D
authors.lastname: Burns
authors.affiliation: J. David Gladstone Institutes, Grant Lab, GIVI, 5th Floor, 1650 Owens Street, San Francisco, 94158, CA, USA. robert.grant@ucsf.edu.|University of California, San Francisco, CA, USA. robert.grant@ucsf.edu.|San Francisco AIDS Foundation, San Francisco, CA, USA. robert.grant@ucsf.edu.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis* / Q000523:psychology; D000068679:Emtricitabine / Q000008:administration & dosage; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D065129:Pre-Exposure Prophylaxis; D012725:Sexual Behavior; D000068698:Tenofovir / Q000008:administration & dosage; D063106:Transgender Persons / Q000706:statistics & numerical data*
chemical_list: D019380:Anti-HIV Agents; D000068698:Tenofovir; D000068679:Emtricitabine
keywords: Depression; FTC/TDF; HIV prevention; Men who have sex with men; PrEP; iPrEx