title: Hepatolithiasis associated with intrahepatic heterotopic pancreas: a case report and literature review.
abstract: Intrahepatic heterotopic pancreas is rarely reported in the literature. Here, we report a case of a 39-year-old male with intrahepatic heterotopic pancreas associated with primary cholesterol hepatolithiasis. Computed tomography (CT) scans revealed multiple cholesterol stones in intrahepatic bile ducts of the left lobe concomitant with intrahepatic cholangiectases. These observations were confirmed by magnetic resonance cholangiopaneretography (MRCP). The patient underwent transabdominal left hepatic lobectomy. Postoperative histological examination of the resected specimen showed pancreatic tissues distributed along the wall of the bile duct and composed of acinar cells and duct elements without islets of Langerhans, therefore strongly suggesting that the heterotopic pancreas occurred in response to chronic injury due to the primary cholesterol hepatolithiasis and was derived from the biliary epithelial cells.
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authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. purprain@163.com.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Yu
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. 3090103947@zju.edu.cn.
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Sun
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. 21418328@zju.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. 274349606@qq.com.
authors.forename: Bei
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, 310012, Zhejing Province, China. 348579180@qq.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Lu
authors.affiliation: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejing University School of Medicine, Hangzhou, 310003, Zhejing Province, China. sunzq@zju.edu.cn.
authors.forename: Shu-Sen
authors.initials: SS
authors.lastname: Zheng
mesh_terms: D000328:Adult; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D002828:Choristoma / Q000473:pathology*; D006801:Humans; D020347:Lithiasis / Q000209:etiology / Q000473:pathology*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D010179:Pancreas