title: Wilfordonols A-D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii.
abstract: Four new norsesquiterpenes wilfordonols A-D (1-4), along with three known compounds, sarmentol B (5), boscialin (6), and (+)-loliolide (7), were isolated from the leaves of Tripterygium wilfordii Hook.f.. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of the compounds was confirmed by CD and modified Mosher's method. At a concentration of 10 μM, compounds 4, 6, and 7 inhibited signal transducer and activator of transcription 1 translocation by 34.27 ± 1.02%, 48.93 ± 1.76%, and 70.31 ± 2.20%, respectively.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ni
authors.forename: Xing
authors.initials: X
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Da-Jian
authors.initials: DJ
authors.lastname: Yang
authors.forename: Yang-Yang
authors.initials: YY
authors.lastname: Shao
authors.forename: Si-Bai
authors.initials: SB
authors.lastname: Zhou
authors.forename: Tian-Tai
authors.initials: TT
authors.lastname: Zhang
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification; D003511:Cyclohexanols / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D003511:Cyclohexanols; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C112713:boscialin; C030425:loliolide
keywords: STAT 1; Tripterygium wilfordii; norsesquiterpene; wilfordonols A–D