title: Risk factor differences between type 2 diabetes patients with ischemic cerebrovascular versus coronary heart diseases at admission.
abstract: OBJECTIVE
  Type 2 diabetes mellitus (T2DM) is a major risk factor, and shares many common risk factors with ischemic cerebrovascular diseases (ICVD) and coronary heart diseases (CHD). Few studies have directly compared the differences in common risk factors between T2DM patients with ICVD and CHD at admission.
  
  
  METHODS
  In this cross-sectional study, T2DM patients with or without first-ever ICVD or CHD admitted to our hospital over 3 years were enrolled. Patients' data were retrospectively collected and compared using multivariate logistic regression analyses.
  
  
  RESULTS
  In total, 1208 T2DM patients were enrolled (57.5% men). The median age was 59 years (interquartile range [IQR] 51-69), and duration of diabetes was 7 years (IQR 3-10). Two hundred and two patients (16.7%) were diagnosed with ICVD, 345 (28.6%) with CHD, and 661 (54.7%) had neither ICVD nor CHD. Compared with T2DM patients without ICVD or CHD, ICVD and CHD patients had higher systolic blood pressure (SBP) and older age but lower high-density lipoprotein cholesterol levels (all p<0.01), whereas reduced estimated glomerular filtration rate was only associated with CHD (p<0.05). Furthermore, ICVD patients had higher SBP (every 10-mmHg increase, OR=1.38, 95% CI: 1.26-1.51) and HbA1c levels (OR=1.18, 95% CI: 1.06-1.31) than CHD patients.
  
  
  CONCLUSIONS
  T2DM patients with ICVD and CHD have differences in common risk factors at admission. Higher systolic blood pressure and HbA1c levels may indicate ICVD.
authors.affiliation: Department of Neurology, The First People's Hospital of Yunnan Province, Kunming 510032, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Shuangquan
authors.initials: S
authors.lastname: Tan
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Yicong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Dang
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: zengjs@pub.guangzhou.gd.cn.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Zeng
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology*; D003327:Coronary Disease / Q000175:diagnosis / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
keywords: At admission; Coronary heart diseases; Ischemic cerebrovascular diseases; Risk factors; Type 2 diabetes mellitus