title: Curcumin-Eudragit® E PO solid dispersion: A simple and potent method to solve the problems of curcumin.
abstract: Using a simple solution mixing method, curcumin was dispersed in the matrix of Eudragit® E PO polymer. Water solubility of curcumin in curcumin-Eudragit® E PO solid dispersion (Cur@EPO) was greatly increased. Based on the results of several tests, curcumin was demonstrated to exist in the polymer matrix in amorphous state. The interaction between curcumin and the polymer was investigated through Fourier transform infrared spectroscopy and (1)H NMR which implied that OH group of curcumin and carbonyl group of the polymer involved in the H bonding formation. Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test. The pH value influenced curcumin release profile in which sustained release pattern was revealed. Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Republic of Korea.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Republic of Korea.
authors.forename: Il Woo
authors.initials: IW
authors.lastname: Lee
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Republic of Korea.
authors.forename: Gye Hwa
authors.initials: GH
authors.lastname: Shin
authors.affiliation: College of Marine Life Science, Ocean University of China, Qingdao 266003, Shandong, PR China.
authors.forename: Xiguang
authors.initials: X
authors.lastname: Chen
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul 136-701, Republic of Korea. Electronic address: hjpark@korea.ac.kr.
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Park
mesh_terms: D002152:Calorimetry, Differential Scanning; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000528:radiation effects; D004339:Drug Compounding; D065546:Drug Liberation; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000528:radiation effects; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014466:Ultraviolet Rays; D014961:X-Ray Diffraction
chemical_list: D011109:Polymethacrylic Acids; C518398:Eudragit E PO; D003474:Curcumin
keywords: Acetone (PubChem CID: 180); Curcumin; Curcumin (PubChem CID: 969516); Eudragit® E PO; Eudragit® E PO (PubChem CID: 107676); Sodium Acetate (PubChem CID: 517045); Solid dispersion; Stability; Transdermal administration; Water solubility