title: Death following ingestion of methylone.
abstract: Methylone is a synthetic derivative of cathinone. It is sold principally on the Internet in powder form under the name «bath salts». Deaths following consumption are very rare. This report details the first case of a death in France (a 21-year-old man), following ingestion of methylone during an evening with friends. Anoxia was observed at the time of autopsy. Toxicological analyses highlighted a consumption of methylone and cannabis. However, biological analyses showed an absence of ethanol, cocaine, amphetamines, and opiate derivatives. Likewise, no medications were found. High concentrations of methylone were found in the peripheral blood (3.13 mg/L) and in the central blood (6.64 mg/L). Its presence in the gastric contents provides evidence that the substance was taken orally. The dosage of δ9-tetrahydrocannabinol (THC) suggests a recent cannabis consumption (THC 12.9 μg/L, THC-COOH 29.3 μg/L, 11-OH-THC 4.9 μg/L). This case illustrates that the consumption of methylone, which has a reputation of being less «powerful» than ecstasy, is not without its dangers.
authors.affiliation: Médecine légale, CHU de NANTES, 1 place Alexis Ricordeau, 44093, Nantes Cedex 1, France. lucia.barrios@chu-nantes.fr.
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, CHU de NANTES, 9 quai Moncousu, 44093, Nantes Cedex 1, France.
authors.forename: H
authors.initials: H
authors.lastname: Grison-Hernando
authors.affiliation: Centre antipoison, CHU d'Angers, 4 rue Larrey, 49000, Angers, France.
authors.forename: D
authors.initials: D
authors.lastname: Boels
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, CHU de NANTES, 9 quai Moncousu, 44093, Nantes Cedex 1, France.
authors.forename: R
authors.initials: R
authors.lastname: Bouquie
authors.affiliation: Laboratoire de Pharmacologie-Toxicologie, CHU de NANTES, 9 quai Moncousu, 44093, Nantes Cedex 1, France.
authors.forename: C
authors.initials: C
authors.lastname: Monteil-Ganiere
authors.affiliation: Médecine légale, CHU de NANTES, 1 place Alexis Ricordeau, 44093, Nantes Cedex 1, France.
authors.forename: R
authors.initials: R
authors.lastname: Clement
mesh_terms: D000284:Administration, Oral; D001646:Bile / Q000737:chemistry; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000032:analysis* / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D013759:Dronabinol / Q000032:analysis; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D005766:Gastrointestinal Contents / Q000737:chemistry; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000506:poisoning; D011619:Psychotropic Drugs / Q000032:analysis; D019966:Substance-Related Disorders / Q000150:complications; D014822:Vitreous Body / Q000737:chemistry; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D011619:Psychotropic Drugs; D008694:Methamphetamine; D013759:Dronabinol; C400939:methylone
keywords: Anoxia; Cathinones; Death; Methylone; Respiratory inhibition