title: Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study.
abstract: OBJECTIVE
  To evaluate the effect of anti-TNF agents plus synthetic disease modifying antirheumatic drugs (DMARDs) versus DMARDs alone for ankylosing spondylitis (AS) with reduced pulmonary function vital capacity (FVC%).
  
  
  METHODS
  In an observational study, we included AS who had FVC% <80% at baseline. Twenty patients were taking DMARDs and 16 received anti-TNF + DMARDs.
  
  
  METHODS
  changes in FVC%, BASDAI, BASFI, 6-minute walk test (6MWT), Borg scale after 6MWT, and St. George's Respiratory Questionnaire at 24 months.
  
  
  RESULTS
  Both DMARDs and anti-TNF + DMARDs groups had similar baseline values in FVC%. Significant improvement was achieved with anti-TNF + DMARDs in FVC%, at 24 months, when compared to DMARDs alone (P = 0.04). Similarly, patients in anti-TNF + DMARDs group had greater improvement in BASDAI, BASFI, Borg scale, and 6MWT when compared to DMARDs alone. After 2 years of follow-up, 14/16 (87.5%) in the anti-TNF + DMARDs group achieved the primary outcome: FVC% ≥80%, compared with 11/20 (55%) in the DMARDs group (P = 0.04).
  
  
  CONCLUSIONS
  Patients with anti-TNF + DMARDs had a greater improvement in FVC% and cardiopulmonary scales at 24 months compared with DMARDs. This preliminary study supports the fact that anti-TNF agents may offer additional benefits compared to DMARDs in patients with AS who have reduced FVC%.
authors.affiliation: Universidad de Colima, 28046 Colima, COL, Mexico ; Centro Universitario de Tonala, Universidad de Guadalajara, 48525 Tonala, JAL, Mexico.
authors.forename: Alberto Daniel
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Aniel Jessica Leticia
authors.initials: AJ
authors.lastname: Brambila-Tapia
authors.affiliation: Departamento de Inmunología, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44670 Guadalajara, JAL, Mexico.
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Zavala-Cerna
authors.affiliation: Centro Universitario de Investigacion Biomedica, Universidad de Colima, 28040 Colima, COL, Mexico.
authors.forename: José Clemente
authors.initials: JC
authors.lastname: Vásquez-Jiménez
authors.affiliation: Coordinación de Investigacion, Division de Cirugia, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", 44280 Guadalajara, JAL, Mexico.
authors.forename: Liliana Faviola
authors.initials: LF
authors.lastname: De la Cerda-Trujillo
authors.affiliation: Instituto de Investigación en Reumatologia y del Sistema Musculoesqueletico, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Mónica
authors.initials: M
authors.lastname: Vázquez-Del Mercado
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico ; Hospital General Regional No. 110, Instituto Mexicano del Seguro Social (IMSS), 44716 Guadalajara, JAL, Mexico.
authors.forename: Norma Alejandra
authors.initials: NA
authors.lastname: Rodriguez-Jimenez
authors.affiliation: Centro Universitario de Investigacion Biomedica, Universidad de Colima, 28040 Colima, COL, Mexico ; Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico.
authors.forename: Valeria
authors.initials: V
authors.lastname: Díaz-Rizo
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico ; Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico.
authors.forename: Viviana
authors.initials: V
authors.lastname: Díaz-González
authors.affiliation: Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Ernesto German
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.affiliation: División de Genetica, Centro de Investigacion Biomedica de Occidente, IMSS, 44340 Guadalajara, JAL, Mexico ; Instituto de Genetica Humana, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Ingrid Patricia
authors.initials: IP
authors.lastname: Dávalos-Rodríguez
authors.affiliation: Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico ; División de Investigacion en Salud, UMAE, CMNO, IMSS, 44340 Guadalajara, JAL, Mexico.
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Paramo
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico ; Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico ; Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Jorge Ivan
authors.initials: JI
authors.lastname: Gamez-Nava
authors.affiliation: Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico ; Facultad de Medicina, Decanato de Ciencias de la Salud, Universidad Autonoma de Guadalajara, 44670 Guadalajara, JAL, Mexico ; Servicio de Medicina Interna, Inmunologia y Reumatologia, Hospital General de Occidente, Secretaria de Salud Jalisco, 45170 Zapopan, JAL, Mexico.
authors.forename: Arnulfo Hernan
authors.initials: AH
authors.lastname: Nava-Zavala
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico ; Hospital General Regional No. 110, Instituto Mexicano del Seguro Social (IMSS), 44716 Guadalajara, JAL, Mexico ; Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Gonzalez-Lopez
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*; D014797:Vital Capacity / Q000187:drug effects*
chemical_list: D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha