title: (18)F-FDG PET/CT and pain in metastatic bone cancer.
abstract: This study aims to determine if the pain intensity of patients with oncologic bone metastases (BM) correlates with metabolic activity measured by (18)F-FDG PET/CT. Twenty-eight patients, ages: 21-89 years (mean: 58.8) with BM were included in the study between September 2011 to September 2013. All patients completed a detailed questionnaire regarding pain symptoms on the visual analog scale (VAS), analgesic use, and areas of chronic pain, prior to obtaining an (18)F-FDG PET/CT. Pain symptoms were queried for 11 body regions including limbs, head, torso, etc. and the corresponding SUVmax of BMs within that region were modeled with the corresponding clinical data using a linear mixed effects model and a linear regression model. Overall 64 areas in the 28 subjects were found to have BM. SUVmax was found to be a significant predictor of pain intensity as measured by the VAS, with a P-value of 0.045, with a modest effect-size on linear regression of R(2) of 0.11.
authors.affiliation: Department of Neurology, University of Wisconsin Madison, WI 53705, USA ; Department of Radiology, Division of Nuclear Medicine, University of Wisconsin - Madison Madison, WI 53705, USA.
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Struck
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, University of Wisconsin - Madison Madison, WI 53705, USA.
authors.forename: Saima
authors.initials: S
authors.lastname: Muzahir
authors.affiliation: Department of Radiology, Division of Nuclear Medicine, University of Wisconsin - Madison Madison, WI 53705, USA.
authors.forename: Lance T
authors.initials: LT
authors.lastname: Hall
keywords: 18F-FDG; SUV pain; bone metastasis