title: [Endoscopic treatment strategy of obstructive hydrocephalus induced by pineal region tumors].
abstract: OBJECTIVE
  To explore the efficacies of endoscopic third ventriculostomy (ETV) and tumor biopsy in surgical treatment of obstructive hydrocephalus induced by pineal region tumors.
  
  
  METHODS
  For 65 patients of obstructive hydrocephalus induced by pineal region tumors, endoscopic third ventriculostomy (ETV) and tumor biopsy were performed from 2012 to 2014. Tumor specimens were harvested and analyzed histopathologically. According to pathological diagnosis, appropriate treatment strategies were followed.
  
  
  RESULTS
  Sixty-five patients underwent successfully ETV and pineal region tumor biopsy. And the histological diagnosis yield rate was 98.5% (64/65). PEB chemotherapy (cisplatin+etoposide+bleomycin) and radiotherapy were offered for germ cell tumors (n = 37) and pineal blastomas (n = 6). The therapy effective rate of germ cell tumors was 91.7% (33/36). A total of 56.9% (37/65) patients benefited without traditional craniotomy or shunt.
  
  
  CONCLUSIONS
  For pineal region tumor induced non-communicating hydrocephalus, ETV and endoscopic tumor biopsy can relieve hydrocephalus while obtaining pathological diagnosis at a relative low risk. Most patients of germ cell tumors and pineoblastomas may avoid craniotomy and shunt. It will become a routine treatment for pineal region tumors with non-communicating hydrocephalus.
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China; Email: 59784555@qq.com.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China.
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China.
authors.forename: Lianyin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurosurgery, Chinese PLA No. 458 Hospital, Guangzhou 510602, China.
authors.forename: Dingbiao
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D001761:Bleomycin; D001932:Brain Neoplasms; D002945:Cisplatin; D003399:Craniotomy; D005047:Etoposide; D006801:Humans; D006849:Hydrocephalus; D044583:Neuroendoscopy; D010870:Pineal Gland; D010871:Pinealoma; D016896:Treatment Outcome; D014696:Ventriculostomy
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin