title: The impact of nandrolone decanoate on the central nervous system.
abstract: Nandrolone is included in the class II of anabolic androgenic steroids (AAS) which is composed of 19-nor-testosterone-derivates. In general, AAS is a broad and rapidly increasing group of synthetic androgens used both clinically and illicitly. AAS in general and nandrolone decanoate (ND) in particular have been associated with several behavioral disorders. The purpose of this review is to summarize the literature concerning studies dealing with ND exposure on animal models, mostly rats that mimic human abuse systems (i.e. supraphysiological doses). We have focused in particular on researches that have investigated how ND alters the function and expression of neuronal signaling molecules that underlie behavior, anxiety, aggression, learning and memory, reproductive behaviors, locomotion and reward.
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Busardò
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy; ; Neuromed, Istituto Mediterraneo Neurologico (IRCCS), Via Atinense 18, Pozzilli, 86077 Isernia, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Frati
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Mariantonia Di
authors.initials: MD
authors.lastname: Sanzo
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Simona
authors.initials: S
authors.lastname: Napoletano
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Enrica
authors.initials: E
authors.lastname: Pinchi
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Simona
authors.initials: S
authors.lastname: Zaami
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy;
authors.forename: Vittorio
authors.initials: V
authors.lastname: Fineschi
mesh_terms: D045930:Anabolic Agents / Q000009:adverse effects*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000523:psychology; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced / Q000523:psychology; D009277:Nandrolone / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate
chemical_list: D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate
keywords: Anabolic androgenic steroids (AAS); Nandrolone decanoate (ND); aggression; anxiety; learning and memory; neurological effects