title: Molecular ping-pong Game of Life on a two-dimensional DNA origami array.
abstract: We propose a design for programmed molecular interactions that continuously change molecular arrangements in a predesigned manner. We introduce a model where environmental control through laser illumination allows platform attachment/detachment oscillations between two floating molecular species. The platform is a two-dimensional DNA origami array of tiles decorated with strands that provide both, the floating molecular tiles to attach and to pass communicating signals to neighbouring array tiles. In particular, we show how algorithmic molecular interactions can control cyclic molecular arrangements by exhibiting a system that can simulate the dynamics similar to two-dimensional cellular automata on a DNA origami array platform.
authors.affiliation: Department of Mathematics and Statistics, University of South Florida, Tampa, FL, USA jonoska@mail.usf.edu.
authors.forename: N
authors.initials: N
authors.lastname: Jonoska
authors.affiliation: Department of Chemistry, New York University, New York, NY, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Seeman
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D007834:Lasers; D008954:Models, Biological; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009991:Oscillometry; D015398:Signal Transduction
chemical_list: D004247:DNA
keywords: DNA origami; DNA signals; Game of Life; cellular automata; laser illumination assembly control; oscillating DNA attachments