title: Solitary pulmonary amyloidoma mimicking lung cancer on 18F-FDG PET-CT scan in systemic lupus erythematosus patient.
abstract: Localized amyloid deposits (tumoral amyloidosis or amyloidoma) are uncommon form of amyloidosis and nodular pulmonary amyloidomas are rarely found. This incidental finding can mimic a bronchopulmonary neoplasm and may occur secondarily to an infectious, inflammatory or lymphoproliferative disease. We report a case of a 62-year-old female with long-standing systemic lupus erythematosus (SLE) with low compliance who presented with radiologically-verified solitary pulmonary nodule. Work-up included positron emission tomography-computed tomography (PET-CT) scan, which revealed hypermetabolic uptake of (18)F-fluorodeoxyglucose, and lobectomy was performed. Staining of the tissue was positive for Congo red and was green birefringent under polarized light. Immunohistochemical methods excluded lymphoproliferative disease and confirmed amyloidoma. SLE was controlled with antimalarials and glucocorticoids. Pulmonary amyloidoma should be considered in the differential diagnosis of solitary lung nodules.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia markobaresic@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Barešić
authors.affiliation: Department of Clinical Immunology, Pulmonology, and Rheumatology, University Hospital Centre "Sestre Milosrdnice", Vinogradska cesta 17, 10000 Zagreb.
authors.forename: K B
authors.initials: KB
authors.lastname: Sreter
authors.affiliation: Department of Pathology, University of Zagreb, School of Medicine, Universitiy Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Brčić
authors.affiliation: Department of Interstitial Diseases, Clinic for Respiratory Diseases "Jordanovac", University of Zagreb, School of Medicine, University Hospital Center Zagreb, Jordanovac 104, 10000 Zagreb, Croatia.
authors.forename: A
authors.initials: A
authors.lastname: Hećimović
authors.affiliation: Department of Thoracic Surgery, Clinic for Respiratory Diseases "Jordanovac", University of Zagreb, School of Medicine, University Hospital Center Zagreb, Jordanovac 104, 10000 Zagreb, Croatia.
authors.forename: Z
authors.initials: Z
authors.lastname: Janevski
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Zagreb, School of Medicine, University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.
authors.forename: B
authors.initials: B
authors.lastname: Anić
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D011859:Radiography; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D003074:Solitary Pulmonary Nodule / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Amyloidoma; PET-CT imaging; lung cancer; solitary lung nodule; systemic lupus erythematosus