title: [Systemic therapy of soft tissue sarcomas].
abstract: Soft tissue sarcomas (STS) comprise a heterogeneous group of rare malignancies from mesenchymal tissues. The biology of STS causes high aggressiveness, poor prognosis due to early development of distant metastases and limited chemotherapeutic options due to tumor resistance. The paper considers the current principles of chemotherapy for early and metastatic disease. Results of own experience of advanced STS patients' treatment are presented and discussed.
authors.forename: A I
authors.initials: AI
authors.lastname: Semenova
authors.forename: S A
authors.initials: SA
authors.lastname: Protsenko
authors.forename: Y I
authors.initials: YI
authors.lastname: Komarov
authors.forename: G M
authors.initials: GM
authors.lastname: Teletaeva
authors.forename: D H
authors.initials: DH
authors.lastname: Latipova
authors.forename: A V
authors.initials: AV
authors.lastname: Novik
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003606:Dacarbazine / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007191:Indazoles; D007211:Indoles / Q000008:administration & dosage; D008297:Male; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends; D020360:Neoadjuvant Therapy / Q000379:methods; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives; D010166:Palliative Care / Q000379:methods; D010671:Phenylurea Compounds / Q000008:administration & dosage; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage; D011859:Radiography; D012509:Sarcoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D000077157:Sorafenib; D013449:Sulfonamides / Q000008:administration & dosage; D000077210:Sunitinib; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000903:Antibiotics, Antineoplastic; D007191:Indazoles; D007211:Indoles; D010671:Phenylurea Compounds; D011743:Pyrimidines; D011758:Pyrroles; D013449:Sulfonamides; C506643:liposomal doxorubicin; D003841:Deoxycytidine; D009536:Niacinamide; D011092:Polyethylene Glycols; D003606:Dacarbazine; C516667:pazopanib; D004317:Doxorubicin; D000077157:Sorafenib; D007069:Ifosfamide; D000077210:Sunitinib; D000093542:Gemcitabine