title: [Depression comorbid to ischemic heart disease: a psychometric and molecular-genetic study].
abstract: OBJECTIVE
  To compare psychometric and molecular-genetic characteristics of depression caused by ischemic heart disease (IHD) and depression in patients with IHD caused by other psychogenic factors.
  
  
  METHODS
  One hundred and thirty-five patients with depression comorbid to ischemic heart disease (IHD) were examined. Depression was associated with IHD in 71 patients (group 1). In 64 patients, depression was caused by other psychogenic factors (group 2). The HAMD-21 scale was used to measure depressive symptoms.
  
  
  CONCLUSIONS
  The comparative analysis of the core symptoms of depression demonstrated that group 1 had a peculiar psychometric profile with marked apathy, which was not accompanied by marked hypothymia, guilt feelings or anxiety, compared to group 2. The molecular-genetic correlate of this profile was found. It included a combination of an allele S (5-HTTLPR) of the serotonin transporter gene, an allele G (A-1438G) of the serotonin receptor type 2A gene and the genotype ValVal (Val66Met) of the brain-derived neurotrophic factor gene.
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.affiliation: Sechenov First Moscow State Medical University, Moscow.
authors.forename: B A
authors.initials: BA
authors.lastname: Volel
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: G I
authors.initials: GI
authors.lastname: Korovaitseva
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Dolzhikov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics* / Q000378:metabolism; D015897:Comorbidity; D004247:DNA / Q000235:genetics*; D003863:Depression / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011594:Psychometrics / Q000379:methods; D012426:Russia / Q000453:epidemiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C579455:BDNF protein, human; D004247:DNA