title: [Roles of biochemical factors in lateral compartment wear from varus knee osteoarthritis].
abstract: OBJECTIVE
  To explore the roles of type II collagen C-terminal telopeptide (CTX-II), matrix metalloproteinase-13 (MMP-13) and interleukin-6 (IL-6) in lateral compartment wear in varus knee osteoarthritis.
  
  
  METHODS
  Prospective reviews were conducted for the clinical data of varus knee osteoarthritis patients with lateral compartment wear undergoing total knee arthropalsty from June 2013 to June 2014. The gross findings of lateral compartment articular cartilage were recorded intraoperatively. And the slices were evaluated histologically. Synovial fluid was obtained by arthrocentesis. An equal number of operative patients from varus knee osteoarthritis without lateral compartment wear during the same period were selected and matched with respects to age, varus, preoperative range of motion and radiological grade of knee arthrosis. Synovial fluid concentrations of CTX-II, MMP-13 and IL-6 were evaluated.
  
  
  RESULTS
  Histologic examination showed microscopic cartilage degeneration in both groups. The concentrations of CTX-II, IL-6 and MMP-13 in synovial fluid from lateral compartment wear group were (111.8±55.7) ng/L, (2.5±1.0) ng/L and (134.4±33.1) µg/L respectively. And there were no differences with control group (91.7±57.1) ng/L, (2.1±0.5) ng/L, (122.7±28.3) µg/L respectively.
  
  
  CONCLUSIONS
  The above biochemical factors may not play key roles in lateral compartment wear of varus knee osteoarthritis.
authors.affiliation: Peking Union Medical College, Beijing 100730, China.
authors.forename: Qidong
authors.initials: Q
authors.lastname: Zhang
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Yu
authors.forename: Liming
authors.initials: L
authors.lastname: Cheng
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Liu
authors.forename: Shilong
authors.initials: S
authors.lastname: Sun
authors.forename: Hongliang
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Joint Surgery, China-Japan Friendship Hospital, Beijing 100029, China; Email: guowanshou@263.net.
authors.forename: Wanshou
authors.initials: W
authors.lastname: Guo
mesh_terms: D001669:Biochemical Phenomena; D002358:Cartilage, Articular; D024043:Collagen Type II; D006801:Humans; D015850:Interleukin-6; D007719:Knee Joint; D053509:Matrix Metalloproteinase 13; D020370:Osteoarthritis, Knee; D010446:Peptide Fragments; D011446:Prospective Studies; D016059:Range of Motion, Articular; D013582:Synovial Fluid
chemical_list: D024043:Collagen Type II; C508600:IL6 protein, human; D015850:Interleukin-6; D010446:Peptide Fragments; C543437:collagen II C-telopeptide; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13