title: Timely blockade of ICAM-1.LFA-1 interaction prevents disease onset in a mouse model of emphysema.
abstract: OBJECTIVE
  It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar to other autoimmune diseases. Costimulatory blockade therapy targets disease-specific T cells, rendering them ineffective by blocking a necessary costimulatory event on the T-cell surface. This therapy is tested here in mouse emphysema.
  
  
  METHODS
  Peptides representing contact domains of counter receptors LFA-1 and ICAM-1 were used as blockade therapy in elastase-induced emphysema.
  
  
  RESULTS
  When administered during the first week after disease induction, blockade prevented lung destruction, reduced leukocyte infiltration and inhibited the decrease in T-cell CD4:CD8 ratio, also common in human emphysema.
  
  
  CONCLUSIONS
  Costimulatory blockade therapy can affect the progress of emphysema.
authors.affiliation: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.|Present address: Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, VA, USA.
authors.forename: Amy H
authors.initials: AH
authors.lastname: Newton
authors.affiliation: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.|Present address: Graduate Program in Immunology, University of Iowa, IA, USA.
authors.forename: Derek B
authors.initials: DB
authors.lastname: Danahy
authors.affiliation: Division of Allergy, Asthma & Immunology, Children's Mercy Hospitals & Clinics, MO, USA.
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Chan
authors.affiliation: Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Benedict
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D004195:Disease Models, Animal; D004646:Emphysema / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: C090509:Icam1 protein, mouse; D016169:Lymphocyte Function-Associated Antigen-1; D010455:Peptides; D018799:Intercellular Adhesion Molecule-1
keywords: ICAM-1; T cell; autoimmune therapy; costimulatory blockade; emphysema; selective immunotherapy