title: Chemical constituents of Abies fabri.
abstract: Systematic phytochemical investigations on Abies fabri resulted in the isolation of 94 compounds, consisting of 68 terpenoids, six lignans, seven flavonoids, and 13 other miscellaneous chemical constituents. Their structures were elucidated on the basis of spectroscopic methods, and the absolute configurations of three of these previously unknown compounds were determined by Cu-Kα X-ray crystallographic analysis. Twelve previously unreported compounds, one artifact, and one potential artifact were identified, including six triterpenoids, four diterpenoids, two sesquiterpenoids, one lignan, and one phenol. 23-Hydroxy-3-oxolanosta-8,24-dien-26,23-olide showed weak cytotoxic activity against A549 and THP-1 cells with the IC50 values of 5.3 and 5.1 μM, respectively.
authors.affiliation: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, Shanghai 201203, China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Gao
authors.affiliation: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors.forename: Wan-Lin
authors.initials: WL
authors.lastname: Chang
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; Laboratory of Cellular and Molecular Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg. Electronic address: xianwen.yang@lih.lu.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
authors.forename: Hua-Wu
authors.initials: HW
authors.lastname: Zeng
authors.affiliation: Laboratory of Cellular and Molecular Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Laboratory of Cellular and Molecular Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526 Luxembourg, Luxembourg.
authors.forename: Andre
authors.initials: A
authors.lastname: Steinmetz
authors.affiliation: School of Pharmacy, Shanghai JiaoTong University, 800 Dongchuan Road, Shanghai 200240, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: wdzhangy@hotmail.com.
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D013729:Terpenes / Q000032:analysis; D014315:Triterpenes / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D017705:Lignans; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; D013729:Terpenes; D014315:Triterpenes; D009569:Nitric Oxide
keywords: Abies fabri; Cu-Kα X-ray crystallography; Cytotoxicity; Diterpenoids; Pinaceae; Triterpenoids