title: [Gastro-esophageal reflux and chronic respiratory diseases].
abstract: Gastroesophageal reflux disease (GERD) frequently occurs in association with chronic respiratory diseases although the casual link is not always clear. Several pathophysiological and experimental factors are considered to support a role for GERD in respiratory disease. Conversely, respiratory diseases and bronchodilator treatment can themselves exacerbate GERD. When cough or severe asthma is being investigated, GERD does not need to be systematically looked for and a therapeutic test with proton pump inhibitors is not always recommended. pH impedance monitoring is now the reference diagnostic tool to detect non acid reflux, a form of reflux for which proton pump inhibitor treatment is ineffective. Recent data have shown a potential role of GERD in idiopathic pulmonary fibrosis and bronchiolitis obliterans following lung transplantation, leading to discussions about the place of surgery in this context. However, studies using pH impedance monitoring are still needed to better understand and manage the association between GERD and chronic respiratory diseases.
authors.affiliation: Université de Nantes, Nantes 44000, France; Institut du thorax, service de pneumologie, hôpital G. et R. Laënnec, CHU de Nantes, boulevard J.-Monod, 44093 Nantes cedex 1, France.
authors.forename: S
authors.initials: S
authors.lastname: Dirou
authors.affiliation: Institut du thorax, service de pneumologie, hôpital G. et R. Laënnec, CHU de Nantes, boulevard J.-Monod, 44093 Nantes cedex 1, France.
authors.forename: P
authors.initials: P
authors.lastname: Germaud
authors.affiliation: Institut des maladies de l'appareil digestif, service d'hépatogastroentérologie et assistance nutritionnelle, CHU de Nantes, Nantes 44093, France; DHU2020 médecine personnalisée des maladies chroniques, Nantes 44000, France.
authors.forename: S
authors.initials: S
authors.lastname: Bruley des Varannes
authors.affiliation: Université de Nantes, Nantes 44000, France; Institut du thorax, service de pneumologie, hôpital G. et R. Laënnec, CHU de Nantes, boulevard J.-Monod, 44093 Nantes cedex 1, France; DHU2020 médecine personnalisée des maladies chroniques, Nantes 44000, France; Inserm, UMR1087, institut du thorax, Nantes 44093, France; CNRS, UMR 6291, Nantes 44000, France.
authors.forename: A
authors.initials: A
authors.lastname: Magnan
authors.affiliation: Université de Nantes, Nantes 44000, France; Institut du thorax, service de pneumologie, hôpital G. et R. Laënnec, CHU de Nantes, boulevard J.-Monod, 44093 Nantes cedex 1, France; DHU2020 médecine personnalisée des maladies chroniques, Nantes 44000, France; Inserm, UMR1087, institut du thorax, Nantes 44093, France; CNRS, UMR 6291, Nantes 44000, France. Electronic address: xavier.blanc@chu-nantes.fr.
authors.forename: F-X
authors.initials: FX
authors.lastname: Blanc
mesh_terms: D001249:Asthma / Q000150:complications; D001982:Bronchial Diseases / Q000150:complications; D002908:Chronic Disease; D003371:Cough / Q000150:complications; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D016040:Lung Transplantation; D011183:Postoperative Complications / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000150:complications; D012120:Respiration Disorders / Q000150:complications*; D012891:Sleep Apnea Syndromes / Q000150:complications
keywords: Asthma; Asthme; Chronic cough; Fibrose pulmonaire idiopathique; Idiopathic pulmonary fibrosis; Inhibiteurs de la pompe à protons; Proton pump inhibitor; Toux chronique; pH impedance monitoring; pH-impédancemétrie