title: [Towards better non-selectivity: the role of 5-HT7 receptors in therapeutic efficacy of a second-generation antipsychotic - lurasidone].
abstract: Effectiveness of currently available antipsychotic medications is far from satisfactory with many patients showing incomplete therapeutic response even after many trials with different antipsychotic drugs. Hence, there is an ongoing interest in searching for pharmacological mechanisms, which could potentiate therapeutic response to antipsychotic drugs and/or reduce its typical side effects. The primary aim of this mini-review is to summarize available evidence supporting the role of serotonin receptors, especially 5-HT7 receptors, in therapeutic effects of a second-generation antipsychotic drug, lurasidone.
authors.affiliation: Instytut Psychiatrii i Neurologii w Warszawie, Zakład Farmakologii.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bieńkowski
authors.affiliation: Zakład Zaburzeń Afektywnych, Katedra Psychiatrii Collegium Medicum UJ.
authors.forename: Dominika
authors.initials: D
authors.lastname: Dudek
authors.affiliation: Pomorski Uniwersytet Medyczny w Szczecinie, Katedra i Klinika Psychiatrii.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D006801:Humans; D054833:Isoindoles / Q000494:pharmacology* / Q000627:therapeutic use*; D000069056:Lurasidone Hydrochloride; D016032:Randomized Controlled Trials as Topic; D011985:Receptors, Serotonin / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D054833:Isoindoles; D011985:Receptors, Serotonin; D013844:Thiazoles; C104425:serotonin 7 receptor; D000069056:Lurasidone Hydrochloride
keywords: bipolar depression; lurasidon; schizophrenia