title: Investigational reverse transcriptase inhibitors for the treatment of HIV.
abstract: BACKGROUND
  While considerable advances have been made in the development of antiretroviral agents, there is still work to be done. Reverse transcriptase inhibitors are important drugs for the treatment of HIV, and considerable research is currently ongoing to develop new agents and to modify currently existing agents.
  
  
  METHODS
  Herein, the authors discuss both investigational nucleoside reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), including agents that are in various stages of development. They also discuss novel formulations that are being investigated for currently available drugs, and discuss the advantages that these new formulations may provide.
  
  
  CONCLUSIONS
  New formulations and co-formulations of currently existing antiretrovirals will represent an important area of development, as a means to improve adherence for HIV-positive individuals. New formulations will continue to be developed, with a focus on allowing for less-frequent administration, as well increasing drug concentrations at local sites such as vaginal tissue, rectal tissue and sites in the immune system.
authors.affiliation: University of Tennessee Health Science Center College of Pharmacy, Department of Clinical Pharmacy , 881 Madison Avenue, Memphis, TN 38163 , USA +1 901 448 7216 ; +1 901 448 1741 ; tcory1@uthsc.edu.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Cory
authors.forename: Narasimha M
authors.initials: NM
authors.lastname: Midde
authors.forename: Pss
authors.initials: P
authors.lastname: Rao
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D015195:Drug Design; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000201:enzymology / Q000821:virology; D006801:Humans; D055118:Medication Adherence; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D015507:Drugs, Investigational; D018894:Reverse Transcriptase Inhibitors
keywords: antiretrovirals; human immunodeficiency virus; investigational drugs; non-nucleoside reverse transcriptase inhibitors; nucleoside reverse transcriptase inhibitors