title: Polyuridylation in Eukaryotes: A 3'-End Modification Regulating RNA Life.
abstract: In eukaryotes, mRNA polyadenylation is a well-known modification that is essential for many aspects of the protein-coding RNAs life cycle. However, modification of the 3' terminal nucleotide within various RNA molecules is a general and conserved process that broadly modulates RNA function in all kingdoms of life. Numerous types of modifications have been characterized, which are generally specific for a given type of RNA such as the CCA addition found in tRNAs. In recent years, the addition of nontemplated uridine nucleotides or uridylation has been shown to occur in various types of RNA molecules and in various cellular compartments with significantly different outcomes. Indeed, uridylation is able to alter RNA half-life both in positive and in negative ways, highlighting the importance of the enzymes in charge of performing this modification. The present review aims at summarizing the current knowledge on the various processes leading to RNA 3'-end uridylation and on their potential impacts in various diseases.
authors.affiliation: Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland ; Department of Molecular Therapeutics, The Scripps Research Institute, 110 Scripps Way, Building A Room A265, Jupiter, FL 33458, USA.
authors.forename: Paola
authors.initials: P
authors.lastname: Munoz-Tello
authors.affiliation: Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.
authors.forename: Lional
authors.initials: L
authors.lastname: Rajappa
authors.affiliation: Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Coquille
authors.affiliation: Department of Molecular Biology, University of Geneva, 1211 Geneva, Switzerland ; University of Bordeaux, European Institute of Chemistry and Biology, ARNA Laboratory, 33607 Pessac, France ; Institut National de la Santé et de la Recherche Médicale, INSERM-U869, ARNA Laboratory, 33000 Bordeaux, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Thore
mesh_terms: D056890:Eukaryota / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D026723:Polyadenylation / Q000235:genetics*; D026721:RNA 3' End Processing / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger; D012343:RNA, Transfer