title: High doses of garlic extract significantly attenuated the ratio of serum LDL to HDL level in rat-fed with hypercholesterolemia diet.
abstract: BACKGROUND
  Hypercholesterolemia is associated with an increased risk of heart disease. In this study, we investigated the antihyperlipidemic effects of garlic (Allium sativum L.) in rat models of hypercholesterolemic.
  
  
  METHODS
  Wistar male rats were randomly divided into 4 diet groups with garlic supplementation. Male Wistar rats were fed by standard pellet diet (group I), standard diet supplemented with 4% garlic (group II), lipogenic diet (containing sunflower oil, cholesterol and ethanol) equivalent to 200 mg raw garlic/kg body weight (raw) (group III) and lipogenic diet equivalent to 400 mg raw garlic/kg body weight (raw) (group IV).
  
  
  RESULTS
  Rats fed 400 g/kg garlic extract(GE), had a significantly lower concentration of serum low-density lipoprotein cholesterol (LDL-C) cholesterol and elevated HDL -C cholesterol at day 28 (P < 0.05).In addition,serum levels of LDL-C was lower in the III and IV group than those in the IV group (P < 0.001 for each). However, cholesterol efflux capacity was positively correlated with HDL cholesterol concentration (P < 0 · 0001). It was also directly correlated with garlic supplementation (P < 0 · 0001).
  
  
  CONCLUSIONS
  Together Taken, the results are clearly indicative of the beneficial effects of garlic in reducing lateral side effects of hyperlipidemia. Our data demonstrate that GE has protective effects on HDL in rats with high LDL intake. Therefore, it could be used to remedy hypercholesterolemia with help reduce risk of coronary heart disease
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1834155749171141.
authors.affiliation: Department of Agricultural Biotechnology, Sari Agricultural Sciences and Natural Resources University, Sari, Iran. Tebrahimi@yahoo.com.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Ebrahimi
authors.affiliation: Shahid Beheshti University of Medical Sciences, Tehran, Iran. BehnooshB@gmail.com.
authors.forename: Behnoosh
authors.initials: B
authors.lastname: Behdad
authors.affiliation: Department of Biochemistry, College of Science, Kurdistan Science and Research Branch, Islamic Azad University, Sanandaj, Iran. Maryamaghaa@gmail.com.|Danesh Pathobiology Laboratory, Tehran, Iran. Maryamaghaa@gmail.com.
authors.forename: Maryam Agha
authors.initials: MA
authors.lastname: Abbasi
authors.affiliation: Shahid Abbas Abdollahi, Molecular Biology Research Center of Shahid Mahallati Hospital, Tabriz, Iran. Rahmanghzadeghan@yahoo.com.
authors.forename: Rahman Ghaffarzadegan
authors.initials: RG
authors.lastname: Rabati
authors.affiliation: Department of Legal Medicine, AJA University of Medical Sciences, Tehran, Iran. Amirff@yahoo.com.
authors.forename: Amir Farshid
authors.initials: AF
authors.lastname: Fayyaz
authors.affiliation: Baqiyatallah University of Medical Sciences, Tehran, Iran. Vahidbehnod@gmail.com.
authors.forename: Vahid
authors.initials: V
authors.lastname: Behnod
authors.affiliation: Department of Infectious Diseases, AJA University of Medical Sciences, Tehran, Iran. aliasgari296@yahoo.com.
authors.forename: Ali
authors.initials: A
authors.lastname: Asgari
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004195:Disease Models, Animal; D005737:Garlic; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010936:Plant Extracts