title: Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response.
abstract: Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to treatment have yet been identified for application in routine practice. Circadian biomarkers may be relevant predictors of individual responses to Li because (1) Li has been shown to affect circadian rhythms, (2) disrupted circadian rhythms are a core expression of susceptibility to BD, and (3) circadian abnormalities during euthymia are associated with relapses.
authors.affiliation: Inserm, U1144, Paris, F-75006, France, pierre.a.geoffroy@gmail.com.
authors.forename: Pierre Alexis
authors.initials: PA
authors.lastname: Geoffroy
authors.forename: Bruno
authors.initials: B
authors.lastname: Etain
authors.forename: Sarah
authors.initials: S
authors.lastname: Sportiche
authors.forename: Frank
authors.initials: F
authors.lastname: Bellivier