title: In vitro testing to a panel of potential chemotherapeutics and current concepts of chemotherapy in benign meningiomas.
abstract: Treatment of benign meningiomas remains a challenge, especially when they involve the skull-base or when surgery and radiation fail. Moreover, a recent in vitro MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) study testing hydroxyurea, temozolomide and other targeting agents failed to identify drugs effective in their treatment; therefore the search for further more effective agents continues. We performed a thorough review of in vitro investigations, animal studies and human clinical trials and endeavoured to integrate our results of MTT assay into current concepts of chemotherapy in benign meningiomas. Our results demonstrated that other chemotherapeutics with various mechanisms of action have the potential to be incorporated into second line therapy. Our study shows for the first time that chemosensitivity/resistance may be associated with histopathological variants of benign meningiomas.
authors.affiliation: Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic. Electronic address: balik.vladimir@gmail.com.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Balik
authors.affiliation: Department of Surgery, Hospital of Slovak Railways and Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 040 01 Kosice, Slovak Republic.
authors.forename: Igor
authors.initials: I
authors.lastname: Sulla
authors.affiliation: Department of Neurosurgery, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Hun Ho
authors.initials: HH
authors.lastname: Park
authors.affiliation: Department of Pharmacology, Faculty of Medicine, P. J. Safarik University, Trieda SNP 1, 040 11 Kosice, Slovak Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Sarissky
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008579:Meningioma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents
keywords: Benign meningioma; Chemotherapy; MTT assay