title: Association of Resistin with Insulin Resistance and Factors of Metabolic Syndrome in North Indians.
abstract: Metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders. The role of resistin in insulin sensitivity and MetS is controversial till date. So, the aim of the present study was to investigate the relationship of plasma resistin levels with markers of the MetS in Indian subjects. In a case control study, total 528 subjects were selected for the study. 265 (194 male and 71 female) were cases (with MetS) and 263 (164 male and 99 female) were controls (without MetS). Required anthropometric measurements and calculations were carried out accordingly. All the Biochemical estimations were carried out according to standard protocol. Resistin level was measured by the standard protocol (By ELISA i.e. enzyme linked immunosorbent assay) as illustrated in the kit. Insulin level was also measured by the standard protocol as illustrated in the kit and insulin resistance was calculated by the standard procedures. Plasma resistin levels were significantly higher in cases compared with controls (male = 13.05 ± 4.31 vs. 7.04 ± 2.09 ng/ml; p ≤ 0.001 and female = 13.53 ± 4.14 vs. 7.42 ± 2.30 ng/ml; p ≤ 0.001). Plasma resistin levels were well correlated with waist circumference, glucose, triglycerides, waist/hip ratio, systolic and diastolic blood pressure, high density lipoprotein, total cholesterol, serum low density lipoprotein, serum very low density lipoprotein, insulin and insulin resistance. Plasma resistin levels were elevated in presence of the MetS and were associated with increased metabolic risk factors.
authors.affiliation: Department of Biochemistry, DBDC & H, Muktsar, 152026 Punjab India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Singh
authors.affiliation: Department of Physiology, King George Medical University (KGMU), Lucknow, India.
authors.forename: Sunita
authors.initials: S
authors.lastname: Tiwari
authors.affiliation: Department of Physiology, King George Medical University (KGMU), Lucknow, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Biochemistry, King George Medical University (KGMU), Lucknow, India.
authors.forename: Kamla Kant
authors.initials: KK
authors.lastname: Shukla
authors.affiliation: Department of Public Health Dentistry, DBDC & H, Muktsar, India.
authors.forename: Kumar Gaurav
authors.initials: KG
authors.lastname: Chhabra
authors.affiliation: Department of Physiology, Uttaranchal Dental College and Medical Research Institute, Uttaranchal, India.
authors.forename: Achileshwar
authors.initials: A
authors.lastname: Pandey
authors.affiliation: In Vitro Toxicology Laboratory, IITR, Lucknow, India.
authors.forename: Aditya Bhushan
authors.initials: AB
authors.lastname: Pant
keywords: Insulin; Insulin resistance; Metabolic syndrome; Resistin; Triglyceride; Waist circumference