title: Total Antioxidant Status in Type 2 Diabetic Patients in Palestine.
abstract: The objective of this study was to compare the level of total antioxidant status (TAS) in type 2 diabetic and normal Palestinian subjects as well as the major factors influencing TAS levels. A sample of convenience composed of 212 type 2 diabetic and 208 normal subjects above the age of 40 were recruited. Only 9.8% of the subjects had normal body mass index (BMI) levels (<25), 29% were overweight (≥25 to <30), and 61.2% were obese (≥30). The mean levels of TAS were significantly higher in diabetic compared to control subjects (2.18 versus 1.84 mM Trolox, P = 0.001) and in hypertensive subjects compared to subjects with normal blood pressure (BP). Mean TAS levels were higher in obese compared to nonobese subjects (2.12 versus 1.85 mM Trolox, P = 0.001). Mean TAS levels were similarly higher in subjects with high fasting plasma glucose (FPG) compared to normal FPG (2.19 versus 1.90 mM Trolox) and high HbA1c (≥6.5%) compared to HbA1c < 6.5% (2.14 versus 1.91 mM Trolox). Multivariate analysis revealed that only diabetic status (P = 0.032) and the level of education (P = 0.036) were significantly associated with TAS. In conclusion diabetic patients had 18.5% increase in TAS levels compared to control subjects.
authors.affiliation: Department of Medical Laboratory Sciences, Faculty of Health Professions, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Akram T
authors.initials: AT
authors.lastname: Kharroubi
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Hisham M
authors.initials: HM
authors.lastname: Darwish
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Mutaz A
authors.initials: MA
authors.lastname: Akkawi
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Abdelkareem A
authors.initials: AA
authors.lastname: Ashareef
authors.affiliation: Department of Biological Sciences, Faculty of Science and Technology, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Zaher A
authors.initials: ZA
authors.lastname: Almasri
authors.affiliation: Faculty of Public Health, Al-Quds University, Jerusalem, State of Palestine.
authors.forename: Khaldoun A
authors.initials: KA
authors.lastname: Bader
authors.affiliation: United Nation Relief and Works Agency (UNRWA), Jerusalem, State of Palestine.
authors.forename: Umaiyeh M
authors.initials: UM
authors.lastname: Khammash
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D018912:Arabs; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000208:ethnology / Q000378:metabolism*; D004522:Educational Status; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D006973:Hypertension / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D008877:Middle East / Q000453:epidemiology; D009752:Nutritional Status / Q000208:ethnology; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D050177:Overweight / Q000150:complications / Q000453:epidemiology / Q000208:ethnology; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; C517652:hemoglobin A1c protein, human