title: [The role of uric acid and allopurinol therapy in cardiovascular disease].
abstract: Uric acid elevation is very common among patients with cardiovascular, renal and metabolic diseases. The role of uric acid in the pathogenesis of these diseases has been subject of intensive research and scientific discussions for decades. Allopurinol, which has been used in clinical practice for almost 50 years, is the drug of first choice for long-term control of gout. Due to its efficiency, low price and well-known risk profile, it is a widely prescribed drug. However allopurinol treatment in patients with asymptomatic hyperuricemia and cardiovascular diseases is still controversial. This review summarizes the increasing evidence of experimental and clinical studies suggesting that uric acid may play a causal role in cardiovascular disorders pathogenesis. The current evidence suggests that allopurinol therapy could provide a clinical benefit in the prevention and treatment in many of these conditions.
authors.forename: Aleš
authors.initials: A
authors.lastname: Linhart
authors.forename: Daniel
authors.initials: D
authors.lastname: Rob
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000652:urine; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy* / Q000652:urine; D014527:Uric Acid / Q000652:urine*
chemical_list: D004791:Enzyme Inhibitors; D014527:Uric Acid; D000493:Allopurinol