title: Serum biomarkers predictive of pre-eclampsia.
abstract: OBJECTIVE
  We sought serum biomarkers predictive of pre-eclampsia (PE).
  
  
  METHODS
  Sera obtained at 12-14 weeks of pregnancy from 24 cases who later developed PE and 24 controls with uncomplicated pregnancies were processed and analyzed using a serum proteomic approach.
  
  
  RESULTS
  Many statistically significant serum PE biomarker candidates (n > 60) were found comparing cases and controls. In addition, logistic regression analysis modeled biomarker data resulted in 14 different multimarker combinations having high detection sensitivity and specificity (AUC >0.9).
  
  
  CONCLUSIONS
  Developed panels of serum biomarkers appeared effective in identifying pregnant women at 12-14 weeks gestation at risk of PE later in their pregnancy.
authors.affiliation: Department of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Anand
authors.affiliation: Department of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Tanielle Mei
authors.initials: TM
authors.lastname: Bench Alvarez
authors.affiliation: Division of Computational Biomedicine, Boston University School of Medicine, Boston University, Boston, MA 02118, USA.
authors.forename: W Evan
authors.initials: WE
authors.lastname: Johnson
authors.affiliation: Maternal Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT 84143, USA.|Maternal Fetal Medicine, University of Utah Health Sciences Center, Salt lake City, UT 84132, USA.
authors.forename: M Sean
authors.initials: MS
authors.lastname: Esplin
authors.affiliation: Department of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Merrell
authors.affiliation: Maternal Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT 84143, USA.|Maternal Fetal Medicine, University of Utah Health Sciences Center, Salt lake City, UT 84132, USA.
authors.forename: T Flint
authors.initials: TF
authors.lastname: Porter
authors.affiliation: Department of Chemistry & Biochemistry, Brigham Young University, Provo, UT 84602, USA.
authors.forename: Steven W
authors.initials: SW
authors.lastname: Graves
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D040901:Proteomics / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D001798:Blood Proteins
keywords: biomarkers; early diagnosis; pre-eclampsia; serum proteomics