title: Acute Myeloid Leukemia With Recurrent Cytogenetic Abnormalities.
abstract: OBJECTIVE
  Session 1 of the 2013 Society for Hematopathology/European Association for Hematopathology Workshop was devoted to the cases of acute myeloid leukemia (AML) with recurrent cytogenetic abnormalities.
  
  
  METHODS
  Based on World Health Organization 2008 criteria, seven specific translocations are defined as "recurrent" in AML. Of these seven, three are considered to be AML defining regardless of blast percentage. Workshop cases provided the opportunity to consider potential new AML-defining cytogenetic mutations, as well as other unique aspects of AML with cytogenetic abnormalities.
  
  
  RESULTS
  Most of the 38 cases submitted were acute promyelocytic leukemia (APL) with t(15;17)(q24.1;q21.1) and so-called variants (12 cases), AML with t(8;21)(q22;q22) (seven cases), AML with inv(3)(q11q26.2) (six cases), and AML with 11q23 translocations (five cases).
  
  
  CONCLUSIONS
  This review focuses on providing updated recommendations for the rapid diagnosis of APL, discussing the types and significance of variant RARA mutations in APL-like leukemias, and refining low-blast-count (oligoblastic) AML. In addition, the significance of unique morphologic, immunophenotypic, and genetic variations in AML defined by a recurrent cytogenetic abnormality is included.
authors.affiliation: From the University of New Mexico Health Sciences Center, Albuquerque, NM and kfoucar@salud.unm.edu.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Foucar
authors.affiliation: University of Chicago Medical Center, Chicago, IL.
authors.forename: John
authors.initials: J
authors.lastname: Anastasi
mesh_terms: D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
keywords: AML; Cytogenetics; Recurrent abnormalities