title: A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.
abstract: A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (USA).
authors.forename: Yunkou
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (USA).
authors.forename: Todd C
authors.initials: TC
authors.lastname: Soesbe
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).
authors.forename: Piyu
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).|Macrocyclics, 1309 Record Crossing, Dallas, TX 75235 (USA).
authors.forename: Garry E
authors.initials: GE
authors.lastname: Kiefer
authors.affiliation: Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA). sherry@utdallas.edu, dean.sherry@utsouthwestern.edu.|Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (USA). sherry@utdallas.edu, dean.sherry@utsouthwestern.edu.
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D060328:Magnetic Phenomena; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D019800:Phenol / Q000737:chemistry; D011522:Protons; D013725:Terbium / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D011522:Protons; D013725:Terbium; D019800:Phenol
keywords: imaging agents; lanthanides; magnetic resonance imaging; magnetization transfer; paraCEST