title: Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson's disease: three case report.
abstract: Wilson's disease (WD), also known as hepatolenticular degeneration, was first described in 1912 by Kinnear Wilson. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The disorder is caused by impairment of the copper transporting ATPase, ATP7B, in the liver, which disturbs copper transport, excretion into the bile, and incorporation into apoceruloplasmin. WD is an inherited copper metabolism disorder with pathological copper accumulation in many tissues, but especially in brain and liver. We conducted this study because copper accumulation in oral tissues in patients with WD have not been studied before. We think that copper accumulation and differences of oxidative events in oral tissues can cause tendency to periodontal diseases.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozturk
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University Ankara, Turkey.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Karacelebi
authors.affiliation: Department of Oral and Dentomaxillofacial Radiology, Faculty of Dentistry, Gazi University Ankara, Turkey.
authors.forename: Kahraman
authors.initials: K
authors.lastname: Gungor
authors.affiliation: Department of Biology, Faculty of Science and Literature, Gazi University Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Coskun
authors.affiliation: Department of Oral and Maxillofacial Surgery, Antera Dental Clinic Antalya, Turkey.
authors.forename: Esma
authors.initials: E
authors.lastname: Boysan
mesh_terms: D001921:Brain / Q000473:pathology; D003300:Copper / Q000378:metabolism*; D005260:Female; D005881:Gingiva / Q000378:metabolism* / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D014070:Tooth / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D003300:Copper
keywords: Wilson’s disease; copper; hepatolenticular degeneration; penicillamine