title: Modeling Fluid Resuscitation by Formulating Infusion Rate and Urine Output in Severe Thermal Burn Adult Patients: A Retrospective Cohort Study.
abstract: Acute burn injuries are among the most devastating forms of trauma and lead to significant morbidity and mortality. Appropriate fluid resuscitation after severe burn, specifically during the first 48 hours following injury, is considered as the single most important therapeutic intervention in burn treatment. Although many formulas have been developed to estimate the required fluid amount in severe burn patients, many lines of evidence showed that patients still receive far more fluid than formulas recommend. Overresuscitation, which is known as "fluid creep," has emerged as one of the most important problems during the initial period of burn care. If fluid titration can be personalized and automated during the resuscitation phase, more efficient burn care and outcome will be anticipated. In the present study, a dynamic urine output based infusion rate prediction model was developed and validated during the initial 48 hours in severe thermal burn adult patients. The experimental results demonstrated that the developed dynamic fluid resuscitation model might significantly reduce the total fluid volume by accurately predicting hourly urine output and has the potential to aid fluid administration in severe burn patients.
authors.affiliation: Burn Research Institute, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Qizhi
authors.initials: Q
authors.lastname: Luo
authors.affiliation: School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zou
authors.affiliation: Burn Research Institute, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Dang
authors.affiliation: School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China.
authors.forename: Kaifa
authors.identifier: 0000-0002-6787-5018
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Biomedical Engineering, Third Military Medical University and Chongqing University, Chongqing 400038, China.
authors.forename: Yongqin
authors.identifier: 0000-0002-6114-2382
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012151:Resuscitation