title: [Adherence with proton pump inhibitor therapy, by continuously taking nonsteroidal anti-inflammatory drugs].
abstract: OBJECTIVE
  To estimate the impact of adherence with proton pump inhibitor (PPI) therapy on the incidence of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy (NSAID gastropathy) in patients with rheumatoid arthritis (RA).
  
  
  METHODS
  PPI pharmacotherapy adherence was estimated using the Medication Adherence Questionnaire (MAQ) in 92 patients with RA, including 32 patients did not take a PPI and 60 used a PPI. The groups were matched for age, disease duration, and used NSAIDs. All those asked underwent video esophagogastroduodenoscopy.
  
  
  RESULTS
  According to the data of MAQ survey, low, moderate, and high adherence subgroups could be identified among the patients treated with a PPI. NSAID gastropathy was detected in 43.8% of the patients taking no PPI, in 50% of those with low PPI treatment adherence, in 12.5% with moderate adherence, and in 4.5% with high adherence. In the patients with low adherence to PPI therapy, NSAID gastropathy was recorded 11 times more frequently than in those with high adherence (c2 = 7.77; p = 0.005). This condition occurred in 28.6% of the patients taking NSAID without preventively using a PPI in the absence of risk factors for NSAID gastropathy.
  
  
  CONCLUSIONS
  Only 36.7% patients who had been recommended to use a PPI for the prevention of NSAID gastropathy strictly observed their doctor's directions. Low PPI pharmacotherapy adherence may serve as an additional risk factor for NSAID gastropathy in patients in whom preventive antisecretory therapy used in combination with NSAID is indicated.
authors.affiliation: Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, Belarus.
authors.forename: S I
authors.initials: SI
authors.lastname: Pimanov
authors.affiliation: Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, Belarus.
authors.forename: E V
authors.initials: EV
authors.lastname: Makarenko
authors.affiliation: Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, Belarus.
authors.forename: E A
authors.initials: EA
authors.lastname: Dikareva
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D002094:Republic of Belarus / Q000453:epidemiology; D012307:Risk Factors; D013272:Stomach Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000517:prevention & control; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D054328:Proton Pump Inhibitors