title: Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva.
abstract: BACKGROUND
  The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people.
  
  
  METHODS
  We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status.
  
  
  RESULTS
  s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 µg/min vs 15.0 µg/min, P = 0.03), even after elimination of the effects of possible confounders.
  
  
  CONCLUSIONS
  DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.
authors.affiliation: Department of Public Health, Hokkaido University Graduate School of Medicine.
authors.forename: Junko
authors.initials: J
authors.lastname: Oikawa
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Ukawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohira
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Kenji
authors.initials: K
authors.lastname: Wakai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ando
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism*; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012463:Saliva / Q000276:immunology* / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007070:Immunoglobulin A; C517652:hemoglobin A1c protein, human