title: Long-term increase in coherence between the basal ganglia and motor cortex after asphyxial cardiac arrest and resuscitation in developing rats.
abstract: BACKGROUND
  The basal ganglia are vulnerable to injury during cardiac arrest. Movement disorders are a common morbidity in survivors. Yet, neuronal motor network changes post-arrest remain poorly understood.
  
  
  METHODS
  We compared function of the motor network in adult rats that, during postnatal week 3, underwent 9.5 min of asphyxial cardiac arrest (n = 9) or sham intervention (n = 8). Six months after injury, we simultaneously recorded local field potentials (LFP) from the primary motor cortex (MCx) and single neuron firing and LFP from the rat entopeduncular nucleus (EPN), which corresponds to the primate globus pallidus pars interna. Data were analyzed for firing rates, power, and coherence between MCx and EPN spike and LFP activity.
  
  
  RESULTS
  Cardiac arrest survivors display chronic motor deficits. EPN firing rate is lower in cardiac arrest survivors (19.5 ± 2.4 Hz) compared with controls (27.4 ± 2.7 Hz; P < 0.05). Cardiac arrest survivors also demonstrate greater coherence between EPN single neurons and MCx LFP (3-100 Hz; P < 0.001).
  
  
  CONCLUSIONS
  This increased coherence indicates abnormal synchrony in the neuronal motor network after cardiac arrest. Increased motor network synchrony is thought to be antikinetic in primary movement disorders. Characterization of motor network synchrony after cardiac arrest may help guide management of post-hypoxic movement disorders.
authors.affiliation: Department of Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri.
authors.forename: Bhooma R
authors.initials: BR
authors.lastname: Aravamuthan
authors.affiliation: Department of Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri.|Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
authors.forename: Michael
authors.initials: M
authors.lastname: Shoykhet
mesh_terms: D000200:Action Potentials; D000367:Age Factors; D000818:Animals; D001237:Asphyxia / Q000150:complications*; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D020392:Entopeduncular Nucleus / Q000473:pathology / Q000503:physiopathology; D006323:Heart Arrest / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D009043:Motor Activity; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology*; D009046:Motor Neurons / Q000473:pathology; D009069:Movement Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D020127:Recovery of Function; D012151:Resuscitation; D013997:Time Factors