title: The predictive value of baseline NAA/Cr for treatment response of first-episode schizophrenia: A ¹H MRS study.
abstract: The study focused on the predictive value of baseline metabolite ratios in bilateral hippocampus of first-episode schizophrenia by using proton magnetic resonance spectroscopy ((1)H MRS). (1)H MRS data were acquired from 23 hallucination and 17 non-hallucination first-episode schizophrenia patients compared with 17 healthy participants. Clinical characteristics of patients were rated using the Positive and Negative Syndrome Scale (PANSS) before and after 3-month treatment. The schizophrenia patients showed lower NAA/Cr ratio than healthy participants respectively (p=0.024; p=0.001), and non-hallucination patients had even lower NAA/Cr ratio than hallucination patients (p=0.033). After 3-month treatment, hallucination patients had greater improvement in negative symptoms than non-hallucination patients (p=0.018). The reduction of PANSS total score and negative factor score was positively correlated with the left NAA/Cr in both group patients (p<0.05). Given that the bilateral hippocampal baseline NAA/Cr had predictive value for the whole treatment response, and the left hippocampal NAA/Cr can predict the prognosis of negative symptoms during acute phase medication in first-episode schizophrenia.
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Weibo
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Hualiang
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Biao
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Huichun
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address: ZLL121@zju.edu.cn.
authors.forename: Leilei
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016022:Case-Control Studies; D003401:Creatine / Q000378:metabolism*; D005260:Female; D006212:Hallucinations / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine
keywords: Hallucination; Magnetic resonance spectroscopy; N-acetylaspartate; Negative symptoms; Prognosis; Schizophrenia