title: Aβ17-20 Peptide-Guided Structuring of Polymeric Conjugates and Their pH-Triggered Dynamic Response.
abstract: The tetrapeptide segment LVFF from the central hydrophobic core of amyloid β-peptide, Aβ17-20 , based methacrylate monomer was polymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization to afford well-defined side-chain peptide polymers. The polymer was transformed to carry primary amino groups in the peptide terminals, depicting pH-responsiveness and was further modified to provide amphiphilic graft copolymer-based nanocarriers with pH-triggered dynamic dye release capability. The polymers acquired α-helical conformation guided by Aβ17-20 peptide. Computational studies were performed to investigate the secondary interactions of the peptide-based materials.
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India. sonukumar@iiserkol.ac.in.
authors.forename: Sonu
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Bheemireddy
authors.affiliation: Department of Chemical Sciences, Polymer Research Centre, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, Nadia, West Bengal, India.
authors.forename: Priyadarsi
authors.initials: P
authors.lastname: De
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D002850:Chromatography, Gel; D002942:Circular Dichroism; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D056004:Molecular Dynamics Simulation; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D016229:Amyloid beta-Peptides; D011108:Polymers; D012996:Solutions
keywords: conformational analysis; drug delivery systems; graft copolymers; nanoparticles; peptides