title: Multidisciplinary Care of Patients with Intrahepatic Cholangiocarcinoma: Updates in Management.
abstract: Cholangiocarcinoma is a highly fatal primary cancer of the bile ducts which arises from malignant transformation of bile duct epithelium. While being an uncommon malignancy with an annual incidence in the United States of 5000 new cases, the incidence has been increasing over the past 30 years and comprises 3% of all gastrointestinal cancers. Cholangiocarcinoma can be classified into intrahepatic (ICC) and extrahepatic (including hilar and distal bile duct) according to its anatomic location within the biliary tree with respect to the liver. This paper reviews the management of ICC, focusing on the epidemiology, risk factors, diagnosis, and surgical and nonsurgical management.
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Lafaro
authors.affiliation: Department of Oncology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: David
authors.initials: D
authors.lastname: Cosgrove
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Jean-Francois H
authors.initials: JF
authors.lastname: Geschwind
authors.affiliation: Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Ihab
authors.initials: I
authors.lastname: Kamel
authors.affiliation: Department of Radiation Oncology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Herman
authors.affiliation: Department of Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Pawlik