title: Amount of folic acid in different types of nutrition used in the neonatal period.
abstract: BACKGROUND
  Folic acid is one of the important supplements for adequate development during pregnancy. A higher intake of folic acid during pregnancy and lactation is recommended.
  
  
  METHODS
  In prospective study the group of premature newborns (n = 52) and the type of nutrition were observed. The red blood cell (RBC) folate concentration levels were determined in the first 24 hours after delivery, before and after oral treatment with folic acid (100 µg/day). Immunochemical analysis for the determination of folate in erythrocytes was performed.
  
  
  RESULTS
  In the group of premature newborns the RBC folate concentration levels after treatment were significantly increased (p < 0.0001). A dynamic increase in the concentration levels of folates in erythrocytes before and after treatment was observed, in spite of the reciprocally decreasing blood count parameters, but without any statistically significant correlation. The infant nutrition before treatment contained significantly higher amount of folic acid in fortified breast milk compared to breast milk (p = 0.04).
  
  
  CONCLUSIONS
  The various types of nutrition for preterm newborns contain a different amount of folic acid. It poses a question of real needs of these patients. The best way to determine the optimal whole amount of folate is to know the real levels of folate in premature newborns (Tab. 2, Fig. 5, Ref. 26). Text in PDF www.elis.sk.
authors.forename: T
authors.initials: T
authors.lastname: Revakova
authors.forename: O
authors.initials: O
authors.lastname: Revak
authors.forename: A
authors.initials: A
authors.lastname: Vasilenkova
authors.forename: D
authors.initials: D
authors.lastname: Behulova
authors.forename: I
authors.initials: I
authors.lastname: Brucknerova
mesh_terms: D000328:Adult; D001942:Breast Feeding; D019587:Dietary Supplements; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008895:Milk, Human; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D005492:Folic Acid
keywords: breast milk; folic acid; milk fortifier; neonatal nutrition.; preterm formula milks