title: Isothermal Titration Calorimetry of Chiral Polymeric Nanoparticles.
abstract: Chiral polymeric nanoparticles are of prime importance, mainly due to their enantioselective potential, for many applications such as catalysis and chiral separation in chromatography. In this article we report on the preparation of chiral polymeric nanoparticles by miniemulsion polymerization. In addition, we describe the use of isothermal titration calorimetry (ITC) to measure the chiral interactions and the energetics of the adsorption of enantiomers from aqueous solutions onto chiral polymeric nanoparticles. The characterization of chirality in nano-systems is a very challenging task; here, we demonstrate that ITC can be used to accurately determine the thermodynamic parameters associated with the chiral interactions of nanoparticles. The use of ITC to measure the energetics of chiral interactions and recognition at the surfaces of chiral nanoparticles can be applied to other nanoscale chiral systems and can provide further insight into the chiral discrimination processes of nanomaterials.
authors.affiliation: Department of Chemistry and the Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel.
authors.forename: Liora
authors.initials: L
authors.lastname: Werber
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany.
authors.forename: Laura C
authors.initials: LC
authors.lastname: Preiss
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
authors.affiliation: Max Planck Institute for Polymer Research, Mainz, Germany.
authors.forename: Rafael
authors.initials: R
authors.lastname: Muñoz-Espí
authors.affiliation: Department of Chemistry and the Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel.
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Mastai
mesh_terms: D002151:Calorimetry; D006358:Hot Temperature; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D011108:Polymers
keywords: amino acids; chiral interactions; isothermal titration calorimetry (ITC); nanomaterials; polymeric nanoparticles