title: Renal involvement in primary Sjögren's syndrome.
abstract: SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.
authors.affiliation: UCL Centre for Nephrology, UCL Medical School, Rowland Hill Street and.
authors.forename: Rhys
authors.initials: R
authors.lastname: Evans
authors.affiliation: UCL Centre for Nephrology, UCL Medical School, Rowland Hill Street and.
authors.forename: Anselm
authors.initials: A
authors.lastname: Zdebik
authors.affiliation: Department of Rheumatology, University College London Hospital, London, UK.
authors.forename: Coziana
authors.initials: C
authors.lastname: Ciurtin
authors.affiliation: UCL Centre for Nephrology, UCL Medical School, Rowland Hill Street and stephen.walsh@ucl.ac.uk.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Walsh
mesh_terms: D004848:Epithelium / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000150:complications*
keywords: B cells; Fanconi syndrome; Sjögren’s syndrome; Th17 cells; autoantibodies; autoimmune epithelialitis; distal renal tubular acidosis; hypocomplementaemia; tubulointerstitial nephritis; vasculitis