title: Influence of factors on mammographic density in premenopausal Chinese women.
abstract: Mammographic density is an independent strong risk factor for breast cancer. However, the influence of factors on mammographic density in premenopausal women remains unclear. In the Southern Professional Women Breast Cancer Screening Project, we assessed the associations between mammographic density and its influential factors using multivariate logistic regression in premenopausal women adjusting for BMI, age, duration of breastfeeding, number of live births, and breast size. A total of 1699 premenopausal women aged 27 to 57 years, who had been screened by mammography, were enrolled in this cross-sectional study. Overall, 85.2% were categorized as having dense breasts (BI-RADS density 3 and 4) and 14.8% as having fatty breasts (BI-RADS density 1 and 2). In multivariate and logistic regression analysis, only BMI and age were significantly negatively correlated with mammographic density in premenopausal women (P<0.001). No significant associations between mammographic density and number of deliveries, breastfeeding duration, education level, family history of breast cancer, as well as breast size and sleep quality, were identified in the study. Age and BMI are negatively associated with mammographic density in premenopausal Chinese women. Information on the influential factors of mammographic density in premenopausal women might provide meaningful insights into breast cancer prevention.
authors.affiliation: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Breast Surgery, Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Yang
authors.forename: Jieqiong
authors.initials: J
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Gu
authors.forename: Yue
authors.initials: Y
authors.lastname: Hu
authors.forename: Fengtao
authors.initials: F
authors.lastname: Liu
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Yun
authors.forename: Qiaozhen
authors.initials: Q
authors.lastname: Xiao
authors.forename: Mei
authors.initials: M
authors.lastname: Wu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Fengxi
authors.initials: F
authors.lastname: Su
mesh_terms: D000328:Adult; D044466:Asian People; D000071060:Breast Density; D001943:Breast Neoplasms / Q000473:pathology*; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D011379:Prognosis; D012307:Risk Factors