title: Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.
abstract: In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FGF23-producing tumour are described.
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Per-Anton
authors.initials: PA
authors.lastname: Westerberg
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Linde
authors.affiliation: Laboratory of diagnostic medicine, Katholieke Universiteit Leuven, Leuven, Belgium ; laboratory of experimental medicine and endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Dirk
authors.initials: D
authors.lastname: Vanderschueren
authors.affiliation: Laboratory of diagnostic medicine, Katholieke Universiteit Leuven, Leuven, Belgium ; laboratory of experimental medicine and endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Jaak
authors.initials: J
authors.lastname: Billen
authors.affiliation: Laboratory of diagnostic medicine, Katholieke Universiteit Leuven, Leuven, Belgium ; laboratory of experimental medicine and endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Ivo
authors.initials: I
authors.lastname: Jans
authors.affiliation: Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
authors.forename: Östen
authors.initials: Ö
authors.lastname: Ljunggren
keywords: FGF23; mineral metabolism; osteomalacia; phosphate