title: Common genetic risk variants are associated with positive symptoms and decision-making ability in patients with schizophrenia.
abstract: Schizophrenia is a clinically heterogeneous disorder associated with broad deficits across cognitive domains. As large genomewide association studies uncover the genetic architecture of schizophrenia, the relationship between common genetic variants and clinical and cognitive characteristics will form part of an integrative approach to understanding genetic effects on the clinical phenotype. In the current study, association between common genetic risk variants and clinical and cognitive variables was investigated. Common risk variants were associated with positive symptoms and decision-making ability from the Cambridge Gambling Task with trends in other domains.
authors.affiliation: University of Queensland, Queensland Brain Institute, St. Lucia, Queensland 4072, Australia. Electronic address: a.martin11@uq.edu.au.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Martin
authors.affiliation: University of Queensland, School of Psychology, St. Lucia, Queensland 4072, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Robinson
authors.affiliation: University of Queensland, Centre for Advanced Imaging, St. Lucia, Queensland 4072, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Reutens
authors.affiliation: University of Queensland, Queensland Brain Institute, St. Lucia, Queensland 4072, Australia; University of Queensland, Queensland Centre for Mental Health Research, Wacol 4076, Queensland.
authors.forename: B
authors.initials: B
authors.lastname: Mowry
mesh_terms: D000328:Adult; D003657:Decision Making; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010641:Phenotype; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*; D012565:Schizophrenic Psychology
keywords: Cognition; Polygene risk scores; Positive symptoms