title: Lewis Acid Catalyzed Annulation of Donor-Acceptor Cyclopropane and N-Tosylaziridinedicarboxylate: One-Step Synthesis of Functionalized 2H-Furo[2,3-c]pyrroles.
abstract: An efficient MgI2-catalyzed annulation between donor-acceptor cyclopropane and N-tosylaziridinedicarboxylate to access highly substituted 2H-furo[2,3-c]pyrrole bearing two rings and four stereocenters, including one quaternary carbon stereocenter, has been developed. This methodology can be used for the synthesis of biologically active compounds like IKM-159. This work also offers an insight into the mechanism of the annulation process.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
authors.forename: Asit
authors.initials: A
authors.lastname: Ghosh
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Pandey
authors.affiliation: Department of Chemistry, Indian Institute of Technology Ropar, Nangal Road, Rupnagar, Punjab 140001, India.
authors.forename: Prabal
authors.initials: P
authors.lastname: Banerjee
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003521:Cyclopropanes / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001388:Aziridines; D001572:Benzofurans; D003521:Cyclopropanes; C552887:IKM 159; D058116:Lewis Acids; C000604557:N-tosylaziridinedicarboxylate; D011758:Pyrroles; D011760:Pyrrolidinones; C030797:cyclopropane