title: [Clinical observations of lenalidomide combination chemotherapy for relapsing or refractory multiple myeloma].
abstract: OBJECTIVE
  To explore the clinical efficacies and toxicities of lenalidomide combination chemotherapy in the treatment of relapsing or refractory multiple myeloma (MM) patients.
  
  
  METHODS
  A total of 14 MM patients were recruited to receive lenalidomide combination chemotherapy in Beijing Chaoyang hospital from June 2013 to October 2014. Lenalidomide 25 mg was taken orally daily or every alternate day for 21 days and resting for 7 days. The regimens were RD (lenalidomide and dexamethasone, n = 6), RCD (lenalidomide, ifosfamide and dexamethasone, n = 4), RDD (lenalidomide, liposomal doxorubicinand dexamethasone, n = 1), PRD (lenalidomide, velcade and dexamethasone, n = 1) and R+DECP (lenalidomide, cisplatin, etoposide, ifosfamide and dexamethasone, n = 2).
  
  
  RESULTS
  Among them, two patients died during the first cycle of lenalidomide. Ten patients finished 2 cycles of treatment and 2 patients attained near complete remission or complete remission (nCR/CR), 6 partial remission (PR) and 2 stable disease (SD) with an overall response rate (ORR) of 8/10. Ten patients finished 3 cycles of treatment and 3 attained CR, 5 PR and 2 SD. Nine patients finished 4 cycles of treatment and 3 attained CR, 5 PR and 1 progressive disease (PD). Six patients finished 5 cycles of treatment and 1 attained CR, 3 PR and 2 PD. Three patients finished 6 cycles of treatment and 1 attained CR, 1 PR and 1 PD. And the most common adverse reactions were fatigue, loss of appetite and hypocytosis. Six patients died.
  
  
  CONCLUSIONS
  The lenalidomide combination chemotherapy is both efficacious and safe in the treatment of relapsing or refractory MM.
authors.affiliation: Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China; Email: lixin0628@sohu.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Wanjun
authors.initials: W
authors.lastname: Sun
authors.forename: Na
authors.initials: N
authors.lastname: An
authors.forename: Zhongxia
authors.initials: Z
authors.lastname: Huang
authors.forename: Shilun
authors.initials: S
authors.lastname: Chen
authors.forename: Man
authors.initials: M
authors.lastname: Shen
authors.forename: Yuping
authors.initials: Y
authors.lastname: Zhong
authors.forename: Jiajia
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiaokai
authors.initials: X
authors.lastname: Zhan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D000068476:Beijing; D006801:Humans; D000077269:Lenalidomide; D009101:Multiple Myeloma; D009364:Neoplasm Recurrence, Local; D012074:Remission Induction; D013792:Thalidomide / Q000031:analogs & derivatives
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide