title: Short- and Long-term weight changes among United States veterans with diffuse large B-cell lymphoma treated with CHOP chemotherapy.
abstract: Identifying weight changes associated with treatment of diffuse large B-cell lymphoma (DLBCL) has the potential to improve the long-term health of survivors. A retrospective cohort of United States veterans with a new diagnosis of DLBCL between October 1, 1998 and September 30, 2008, with follow-up until April 23, 2013, was assembled. Weight changes were evaluated before, during, and after treatment in 1935 DLBCL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisone, with or without rituximab (CHOP+/- R). One year prior to treatment, 79% of patients were obese or overweight. During the 12 months leading up to treatment, 57% of the cohort lost weight. Among patients surviving 24 months after treatment initiation, weight increased an average of 2.9 kg above weight at treatment completion. The weight change trends observed in these DLBCL patients suggest that weight management strategies may be an important part of long-term survivorship planning after conclusion of treatment.
authors.affiliation: a Research Service, St. Louis Veterans Affairs Medical Center , St. Louis , MO , USA.|b Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Katiuscia
authors.initials: K
authors.lastname: O'Brian
authors.affiliation: a Research Service, St. Louis Veterans Affairs Medical Center , St. Louis , MO , USA.|b Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Suhong
authors.initials: S
authors.lastname: Luo
authors.affiliation: c Department of Emergency Medicine , University of Michigan Health System , Ann Arbor , MI , USA.
authors.forename: Arun
authors.initials: A
authors.lastname: Ganti
authors.affiliation: b Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Riedell
authors.affiliation: d Division of Oncology, Department of Medicine , Stanford University School of Medicine/Stanford Cancer Institute , Stanford , CA , USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Lynch
authors.affiliation: e Northwest Oncology and Hematology, Kalispell Regional Medical Center , Kalispell , MT , USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Roop
authors.affiliation: a Research Service, St. Louis Veterans Affairs Medical Center , St. Louis , MO , USA.|b Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Sanfilippo
authors.affiliation: a Research Service, St. Louis Veterans Affairs Medical Center , St. Louis , MO , USA.
authors.forename: Weijian
authors.initials: W
authors.lastname: Liu
authors.affiliation: f Division of Public Health Sciences, Department of Surgery , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Graham A
authors.initials: GA
authors.lastname: Colditz
authors.affiliation: a Research Service, St. Louis Veterans Affairs Medical Center , St. Louis , MO , USA.|b Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , MO , USA.|f Division of Public Health Sciences, Department of Surgery , Washington University School of Medicine , St. Louis , MO , USA.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Carson
keywords: CHOP chemotherapy; lymphoma; veterans; weight change