title: Patient with inoperable pheochromocytoma.
abstract: Malignant pheochromocytoma is a tumour with a very low incidence that occurs sporadically or in the presence of multiple endocrine neoplasia. We present the case of a woman with a sporadic occurrence of pheochromocytoma diagnosed in the phase of multiple dissemination in the abdominal cavity and overexpressing adrenaline, noradrenaline, and dopamine. Local transarterial chemoembolization and systemic treatment with lanreotide resulted in a very good response, a decrease in the production of catecholamines for 12 months and a partial decrease for another 8 months, with stabilization of disease determined by imaging. Systemic treatment with tegafur resulted in disease stabilization lasting 50 months, after which the drug was discontinued because of adverse effects. Maintenance therapy with lanreotide continues, and no disease progression has been observed for 4 months. The treatment algorithm for such patients is multidisciplinary and must always take into account the current scope of the disease, intercurrence, and the general condition of the patient.
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Internal Hematological and Oncological Clinic, University Hospital Brno, Brno, Czech Republic;
authors.forename: D
authors.initials: D
authors.lastname: Brancíková
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Internal Hematological and Oncological Clinic, University Hospital Brno, Brno, Czech Republic;
authors.forename: Z
authors.initials: Z
authors.lastname: Mechl
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Internal Hematological and Oncological Clinic, University Hospital Brno, Brno, Czech Republic;
authors.forename: Z
authors.initials: Z
authors.lastname: Adam
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Institute of Pathology, University Hospital Brno, Brno, Czech Republic;
authors.forename: E
authors.initials: E
authors.lastname: Jandáková
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Department of Radiology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Pavlovský
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Department of Radiology, University Hospital Brno, Brno, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Válek
authors.affiliation: Medical Faculty, Masaryk University, Brno, Czech Republic; ; Department of Radiology, University Hospital Brno, Brno, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Andrašina
keywords: Pheochromocytoma; chemoembolization; lanreotide