title: Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life.
abstract: Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.
authors.affiliation: Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Minglan
authors.initials: M
authors.lastname: Li
authors.affiliation: Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Clare M
authors.initials: CM
authors.lastname: Reynolds
authors.affiliation: Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Segovia
authors.affiliation: Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Clint
authors.identifier: 0000-0002-0659-8694
authors.initials: C
authors.lastname: Gray
authors.affiliation: Liggins Institute and Gravida: National Centre for Growth and Development, University of Auckland, Auckland 1142, New Zealand.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Vickers
mesh_terms: D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000209:etiology* / Q000503:physiopathology; D009752:Nutritional Status; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors