title: Relationships between plasma pentraxin 3 levels and inflammation markers patients with tunneled permanent catheter in hemodialysis.
abstract: OBJECTIVE
  Vascular access (VA) devices may contribute to chronic inflammation in hemodialysis (HD). Pentraxin 3 (PTX3) is a recently discovered acute phase protein that responds more rapidly than other inflammatory markers. This study compared PTX3 and other markers between HD patients and healthy controls.
  
  
  METHODS
  The study population included 30 patients with tunneled permanent catheter (TPC), 30 patients with arteriovenous fistula (AVF) and 30 healthy controls. Hemogram, biochemical assays, ferritin, high sensitive C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and PTX3 were evaluated in all groups.
  
  
  RESULTS
  PTX levels were highest in HD patients with TPC, intermediated in HD patients with AVF and lowest in healthy controls (5.2 + 2.4 vs. 3.1 + 1.3 vs. 1.8 + 0.7, p&lt;0.001 for all comparisons). PTX3 levels correlated strongly to hs-CRP (r = 0.857) and moderately to TNF-α, NLR, ferritin and total neutrophil count. PTX3 and albumin levels had a negative correlation. PTX3 levels were higher in patients with 8 months of TPC than those with 7 months or less.
  
  
  CONCLUSIONS
  PTX3 levels are significantly elevated in all patients on HD, but presence and extended duration of TPC are associated with incrementally higher levels of PTX3 and other inflammatory markers. PTX3 and NLR may be useful in assessing chronic inflammatory states in HD.
authors.affiliation: 1 Department of Nephrology, Malatya Government Hospital, Malatya - Turkey.
authors.forename: Irem Pembegul
authors.initials: IP
authors.lastname: Yigit
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dogukan
authors.forename: Hulya
authors.initials: H
authors.lastname: Taskapan
authors.forename: Melda
authors.initials: M
authors.lastname: Comert
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ulu
authors.forename: Bilge
authors.initials: B
authors.lastname: Aygen
mesh_terms: D000328:Adult; D000368:Aged; D001166:Arteriovenous Shunt, Surgical; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002404:Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling; D004867:Equipment Design; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D062666:Vascular Access Devices; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D000683:Serum Amyloid P-Component; D000099153:Pentraxins