title: Potential benefits and limitations of utilizing chondroprogenitors in cell-based cartilage therapy.
abstract: Chondroprogenitor cells are a subpopulation of multipotent progenitors that are primed for chondrogenesis. They are believed to have the biological repertoire to be ideal for cell-based cartilage therapy. In addition to summarizing recent advances in chondroprogenitor cell characterization, this review discusses the projected pros and cons of utilizing chondroprogenitors in regenerative medicine and compares them with that of pre-existing methods, including autologous chondrocyte implantation (ACI) and the utilization of bone marrow derived mesenchymal stem cells (MSCs) for the purpose of cartilage tissue repair.
authors.affiliation: Department of Orthopedics, Warren Alpert Medical School of Brown University , Providence, RI , USA.
authors.forename: Chathuraka T
authors.initials: CT
authors.lastname: Jayasuriya
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D064592:Autografts; D019902:Chondrocytes / Q000378:metabolism / Q000637:transplantation*; D020219:Chondrogenesis; D006801:Humans; D039902:Multipotent Stem Cells / Q000378:metabolism / Q000637:transplantation*; D044968:Regenerative Medicine / Q000379:methods*
keywords: Cartilage therapy; chondroprogenitor; osteoarthritis; progenitor; stem cell