title: Modeling of cell adhesion and deformation mediated by receptor-ligand interactions.
abstract: The current work is devoted to studying adhesion and deformation of biological cells mediated by receptors and ligands in order to enhance the existing models. Due to the sufficient in-plane continuity and fluidity of the phospholipid molecules, an isotropic continuum fluid membrane is proposed for modeling the cell membrane. The developed constitutive model accounts for the influence of the presence of receptors on the deformation and adhesion of the cell membrane through the introduction of spontaneous area dilation. Motivated by physics, a nonlinear receptor-ligand binding force is introduced based on charge-induced dipole interaction. Diffusion of the receptors on the membrane is governed by the receptor-ligand interaction via Fick's Law and receptor-ligand interaction. The developed model is then applied to study the deformation and adhesion of a biological cell. The proposed model is used to study the role of the material, binding, spontaneous area dilation and environmental properties on the deformation and adhesion of the cell.
authors.affiliation: Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8W 3P6, Canada.
authors.forename: Amirreza F
authors.initials: AF
authors.lastname: Golestaneh
authors.affiliation: Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8W 3P6, Canada. bnadler@uvic.ca.
authors.forename: Ben
authors.initials: B
authors.lastname: Nadler
mesh_terms: D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D004058:Diffusion; D008024:Ligands; D008954:Models, Biological; D011312:Pressure; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013314:Stress, Mechanical
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface
keywords: Cell adhesion; Fluid membrane; Receptor diffusion; Receptor–ligand interaction