title: Schwannomas exhibit distinct size-dependent gene-expression patterns.
abstract: OBJECTIVE
  Neurofibromatosis type 2 (NF2)-associated vestibular schwannomas have variable size at presentation which presents a unique challenge in NF2 patient management. Therefore, we investigated the molecular signature characteristic of the differences in size for improved individualized precise therapy.
  
  
  METHODS
  RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47,000 transcripts.
  
  
  RESULTS
  A signature of 11 genes was found to be correlated with NF2 tumor size.
  
  
  CONCLUSIONS
  We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size.
authors.affiliation: Department of Pediatric Hemato-Oncology, The Cancer Research Center, Sheba Medical Center, 2 Sheba Road, Ramat Gan, 52621, Israel.
authors.forename: Ruty
authors.initials: R
authors.lastname: Mehrian-Shai
authors.affiliation: Department of Pediatric Hemato-Oncology, The Cancer Research Center, Sheba Medical Center, 2 Sheba Road, Ramat Gan, 52621, Israel.
authors.forename: Shany
authors.initials: S
authors.lastname: Freedman
authors.affiliation: BioDiscovery, 5155 W Rosecrans Ave # 310, Hawthorne, CA 90250, USA.
authors.forename: Soheil
authors.initials: S
authors.lastname: Shams
authors.affiliation: Head & Neck Surgery, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093, USA.
authors.forename: Joni
authors.initials: J
authors.lastname: Doherty
authors.affiliation: Department of Clinical Studies, House Ear Institute, 2100 W 3rd St #500, Los Angeles, CA 90057, USA.
authors.forename: William
authors.initials: W
authors.lastname: Slattery
authors.affiliation: Beth Israel Hospital, 110 Francis St #3B, Boston, MA 02215, USA.
authors.forename: Nancy Ya-Hsuan
authors.initials: NY
authors.lastname: Hsu
authors.affiliation: Division of Tropical Health & Medicine, James Cook University, Townsville, QLD, Australia.
authors.forename: Juergen K V
authors.initials: JK
authors.lastname: Reichardt
authors.affiliation: Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Andalibi
authors.affiliation: Department of Pediatric Hemato-Oncology, The Cancer Research Center, Sheba Medical Center, 2 Sheba Road, Ramat Gan, 52621, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Toren
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D016518:Neurofibromatosis 2 / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009464:Neuroma, Acoustic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D059467:Transcriptome; D047368:Tumor Burden; D055815:Young Adult
keywords: brain cancer; neurofibromatosis; schwannomas; tumor growth; tumor signature