title: [Prophylaxis of purulent complications in mechanical ileus].
abstract: In experiment, while simulating an acute ileus, the possibility of antibacterial preparations for prophylaxis of purulent--septic complications was studied. There was established, that while progressing purulent intestinal inflammation its wall already in 12 h losses a capacity to cumulate penicillines and aminoglycosides. In a phlegmon-like changed intestine during 48 h cephalosporins and fluorochinolons are accumulated in bactericidal concentration, making a destruction of intestinal wall and occurrence of purulent peritonitis by 6-12 h slower.
authors.forename: T I
authors.initials: TI
authors.lastname: Tamm
authors.forename: V V
authors.initials: VV
authors.lastname: Nepomnyashchiy
authors.forename: E A
authors.initials: EA
authors.lastname: Shakalova
authors.forename: I A
authors.initials: IA
authors.lastname: Dvornik
mesh_terms: D000667:Ampicillin / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001692:Biological Transport; D002511:Cephalosporins / Q000493:pharmacokinetics / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives; D004195:Disease Models, Animal; D024841:Fluoroquinolones / Q000493:pharmacokinetics / Q000494:pharmacology; D005839:Gentamicins / Q000493:pharmacokinetics / Q000494:pharmacology; D045823:Ileus / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D005839:Gentamicins; C093087:cifran; D002939:Ciprofloxacin; D000667:Ampicillin