title: SnapShot: Growing Organoids from Stem Cells.
abstract: Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.
authors.affiliation: Department of Gastroenterology, Keio University School of Medicine, 160-8582 Tokyo, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sato
authors.affiliation: Hubrecht Institute, KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Clevers
mesh_terms: D000818:Animals; D004064:Digestive System / Q000166:cytology; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D009940:Organoids; D039904:Pluripotent Stem Cells / Q000166:cytology; D013234:Stem Cells / Q000166:cytology*; D046509:Tissue Culture Techniques; D057170:Translational Research, Biomedical