title: [Personalized pharmacotherapy of digoxin].
abstract: BACKGROUND
  Therapeutic and toxic effects of digoxin are related to its serum concentrations, recent evidence suggests that a lower therapeutic range 0.5-0.9 ng/ml is associated with reduced mortality.
  
  
  OBJECTIVE
  To show the advantages of therapeutic drug monitoring for dosing of digoxin.
  
  
  METHODS
  Trough serum levels of digoxin were estimated by immunoassay MEIA (AxSym Abbott). The long term serum concentration - time profile of digoxin has been predicted by the Bayesian analysis computer program MW-Pharm 3.30 MediWare.
  
  
  RESULTS
  Sex case reports of the patients between 71 to 92 years are presented to show the different doses to receive digoxin levels in the therapeutic range. The doses varies between 0.03-0.25 mg per day.
  
  
  CONCLUSIONS
  Therapeutic drug monitoring is very usefull for prediction of serum level of digoxin. There is no need to wait for a steady-state condition before performing therapeutic drug monitoring.
authors.forename: Milan
authors.initials: M
authors.lastname: Grundmann
authors.forename: Ivana
authors.initials: I
authors.lastname: Kacířová
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001499:Bayes Theorem; D002316:Cardiotonic Agents / Q000493:pharmacokinetics; D004077:Digoxin / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male
chemical_list: D002316:Cardiotonic Agents; D004077:Digoxin