title: Prophylactic oophorectomy for hereditary small cell carcinoma of the ovary, hypercalcemic type.
abstract: •Prophylactic oophorectomy can prevent small cell carcinoma of the ovary, hypercalcemic type in carriers of germline SMARCA4 mutations.•Unaffected SMARCA4 mutation carriers who desire children may be best served by oocyte cryopreservation prior to prophylactic oophorectomy.
authors.affiliation: Duke University Medical Center, Durham, NC, United States.
authors.forename: Andrew
authors.initials: A
authors.lastname: Berchuck
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada.
authors.forename: Leora
authors.initials: L
authors.lastname: Witkowski
authors.affiliation: Institute of Neuropathology, University Hospital Münster, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Hasselblatt
authors.affiliation: Department of Human Genetics, McGill University, Montreal, QC, Canada.
authors.forename: William D
authors.initials: WD
authors.lastname: Foulkes
keywords: Ovarian cancer; Prophylactic oophorectomy; SMARCA4 mutation