title: Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance.
abstract: A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR. guangzhu@cityu.edu.hk.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Chen
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002735:Chlorophyllides; D019008:Drug Resistance, Neoplasm; D006801:Humans; D006878:Hydroxides / Q000008:administration & dosage* / Q000494:pharmacology; D053758:Nanoparticles / Q000008:administration & dosage*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology; D017671:Platinum Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D011166:Porphyrins / Q000008:administration & dosage* / Q000494:pharmacology; D011355:Prodrugs / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D002735:Chlorophyllides; D006878:Hydroxides; D017319:Photosensitizing Agents; D017671:Platinum Compounds; D011166:Porphyrins; D011355:Prodrugs; C062985:phytochlorin