title: Quantification of Dynamic [18F]FDG Pet Studies in Acute Lung Injury.
abstract: OBJECTIVE
  This work aims to investigate lung glucose metabolism using 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomography (PET) imaging in acute lung injury (ALI) patients.
  
  
  METHODS
  Eleven ALI patients and five healthy controls underwent a dynamic [(18)F]FDG PET/X-ray computed tomography (CT) scan. The standardized uptake values (SUV) and three different methods for the quantification of glucose metabolism (i.e., ratio, Patlak, and spectral analysis iterative filter, SAIF) were applied both at the region and the voxel levels.
  
  
  RESULTS
  SUV reported a lower correlation than the ratio with the net tracer uptake. Patlak and SAIF analyses did not show any significant spatial or quantitative (R(2) > 0.80) difference. The additional information provided by SAIF showed that in lung inflammation, elevated tracer uptake is coupled with abnormal tracer exchanges within and between lung tissue compartments.
  
  
  CONCLUSIONS
  Full kinetic modeling provides a multi-parametric description of glucose metabolism in the lungs. This allows characterizing the spatial distribution of lung inflammation as well as returning the functional state of the tissues.
authors.affiliation: Division of Imaging Science and Biomedical Engineering, King's College London, London, UK.|Department of Information Engineering (DEI), University of Padova, Via G. Gradenigo 6/B, 35131, Padova, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Grecchi
authors.affiliation: Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.|Department of Information Engineering (DEI), University of Padova, Via G. Gradenigo 6/B, 35131, Padova, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Veronese
authors.affiliation: Tecnomed Foundation, University of Milan-Bicocca, Milan, Italy.
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Moresco
authors.affiliation: Department of Health Science, University of Milan-Bicocca, Monza, Italy.|Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Bellani
authors.affiliation: Department of Health Science, University of Milan-Bicocca, Monza, Italy.|Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pesenti
authors.affiliation: Tecnomed Foundation, University of Milan-Bicocca, Milan, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Messa
authors.affiliation: Department of Information Engineering (DEI), University of Padova, Via G. Gradenigo 6/B, 35131, Padova, Italy. bertoldo@dei.unipd.it.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Bertoldo
mesh_terms: D055371:Acute Lung Injury / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D017711:Nonlinear Dynamics; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Acute lung injury; Parametric imaging; Positron emission tomography; Spectral analysis; [18F]FDG