title: Dietary modification and supplementation for the treatment of age-related macular degeneration.
abstract: Age-related macular degeneration (AMD) causes a significant proportion of visual loss in the developed world. Currently, little is known about its pathogenesis, and treatment options are limited. Dietary intake is one of the few modifiable risk factors for this condition. The best-validated therapies remain oral antioxidant supplements based on those investigated in the Age-Related Eye Disease Study (AREDS) and the recently completed Age-Related Eye Disease Study 2 (AREDS2). In this review, current dietary guidelines related to AMD, along with the underlying evidence to support them, are presented in conjunction with current treatment recommendations. Both AREDS and AREDS2 are discussed, as are avenues for further research, including supplementation with vitamin D and saffron. Despite the considerable disease burden of atrophic AMD, few effective therapies are available to treat it, and further research is required.
authors.affiliation: G.K. Broadhead, J. Grigg, A.A Chang, and P. McCluskey are with the Save Sight Institute, Department of Ophthalmology, The University of Sydney, Sydney, New South Wales, 2000, Australia. G.K. Broadhead and A.A Chang are with the Sydney Institute of Vision Science, Sydney, New South Wales, 2000, Australia. gbro8081@uni.sydney.edu.au.
authors.forename: Geoffrey K
authors.initials: GK
authors.lastname: Broadhead
authors.affiliation: G.K. Broadhead, J. Grigg, A.A Chang, and P. McCluskey are with the Save Sight Institute, Department of Ophthalmology, The University of Sydney, Sydney, New South Wales, 2000, Australia. G.K. Broadhead and A.A Chang are with the Sydney Institute of Vision Science, Sydney, New South Wales, 2000, Australia.
authors.forename: John R
authors.initials: JR
authors.lastname: Grigg
authors.affiliation: G.K. Broadhead, J. Grigg, A.A Chang, and P. McCluskey are with the Save Sight Institute, Department of Ophthalmology, The University of Sydney, Sydney, New South Wales, 2000, Australia. G.K. Broadhead and A.A Chang are with the Sydney Institute of Vision Science, Sydney, New South Wales, 2000, Australia.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Chang
authors.affiliation: G.K. Broadhead, J. Grigg, A.A Chang, and P. McCluskey are with the Save Sight Institute, Department of Ophthalmology, The University of Sydney, Sydney, New South Wales, 2000, Australia. G.K. Broadhead and A.A Chang are with the Sydney Institute of Vision Science, Sydney, New South Wales, 2000, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: McCluskey
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002338:Carotenoids / Q000008:administration & dosage; D002784:Cholesterol / Q000008:administration & dosage; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D019587:Dietary Supplements; D018450:Disease Progression; D002149:Energy Intake; D005247:Feeding Behavior; D005399:Fishes; D006801:Humans; D008268:Macular Degeneration / Q000178:diet therapy* / Q000235:genetics; D018977:Micronutrients / Q000008:administration & dosage; D018673:Nutrition Policy; D009754:Nuts; D017747:Seafood; D014675:Vegetables; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D018977:Micronutrients; D014807:Vitamin D; D002338:Carotenoids; D002784:Cholesterol
keywords: Age-related macular degeneration; antioxidants; diet; dietary supplements.