title: Immunomodulatory and Antioxidant Effects of Purple Sweet Potato Extract in LP-BM5 Murine Leukemia Virus-Induced Murine Acquired Immune Deficiency Syndrome.
abstract: The immunomodulatory effects of a dietary supplement of purple sweet potato extract (PSPE) in LP-BM5 murine leukemia virus (MuLV)-induced immune-deficient mice were investigated. Mice were divided into six groups: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300 mg/kg), purple sweet potato water extract (PSPWE) (LP-BM5 MuLV infection+dietary supplement of PSPE 300 mg/kg), PSP10EE (LP-BM5 MuLV infection+dietary supplement of 10% ethanol PSPE 300 mg/kg), and PSP80EE (LP-BM5 MuLV infection+dietary supplement of 80% ethanol PSPE 300 mg/kg). Dietary supplementation began on the day of LP-BM5 MuLV infection and continued for 12 weeks. Dietary supplementation of PSPE inhibited LP-BM5 MuLV-induced splenomegaly and lymphadenopathy and attenuated the suppression of T- and B-cell proliferation and T helper 1/T helper 2 cytokine imbalance in LP-BM5 MuLV-infected mice. Dietary supplement of PSPE increased the activity of the antioxidant enzymes, superoxide dismutase and glutathione peroxidase. The data suggest that PSPE may ameliorate immune dysfunction due to LP-BM5 MuLV infection by modulating antioxidant defense systems.
authors.affiliation: 1 Department of Medical Nutrition, Kyung Hee University , Yongin, Korea.
authors.forename: Ok-Kyung
authors.initials: OK
authors.lastname: Kim
authors.affiliation: 1 Department of Medical Nutrition, Kyung Hee University , Yongin, Korea.
authors.forename: Da-Eun
authors.initials: DE
authors.lastname: Nam
authors.affiliation: 2 Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine , Seoul, Korea.
authors.forename: Ho-Geun
authors.initials: HG
authors.lastname: Yoon
authors.affiliation: 1 Department of Medical Nutrition, Kyung Hee University , Yongin, Korea.
authors.forename: Sun Jung
authors.initials: SJ
authors.lastname: Baek
authors.affiliation: 3 Department of Food and Nutrition, Chonnam National University , Gwangju, Korea.
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
authors.affiliation: 1 Department of Medical Nutrition, Kyung Hee University , Yongin, Korea.|4 Research Institute of Clinical Nutrition, Kyung Hee University , Seoul, Korea.
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000032:analysis; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D056747:Immunomodulation / Q000187:drug effects*; D027723:Ipomoea batatas / Q000737:chemistry* / Q000276:immunology*; D009052:Leukemia Virus, Murine / Q000472:pathogenicity; D008206:Lymphatic Diseases / Q000178:diet therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D010936:Plant Extracts / Q000494:pharmacology; D028321:Plant Preparations / Q000737:chemistry; D013163:Splenomegaly / Q000178:diet therapy; D013482:Superoxide Dismutase / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects
chemical_list: D000975:Antioxidants; D016207:Cytokines; D010936:Plant Extracts; D028321:Plant Preparations; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: antioxidant activity; cytokines; immunomodulation