title: Left Ventricular Mass as a Risk Factor in the Oldest Old.
abstract: In middle-aged and "young elderly" cohorts, higher left ventricular mass (LVM) is associated with worse outcomes. The authors examined LVM and 5-year mortality among community-dwelling 85-year-old patients. A representative sample (n=526, born 1920-1921) from the Jerusalem Longitudinal Cohort Study underwent echocardiography at age 85. LVM was indexed by body surface area (LVM-BSA) or height (LVM-Ht). Patients with higher LVM were less educated and sedentary and had poorer self-rated health, functional limitations, and increased comorbidity. Five-year mortality was 21.7% (n=114). Adjusted 5-year mortality rates were increased for the two upper quintiles of LVM-BSA (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.05-3.06) and LVM-Ht (HR, 2.2; 95% CI, 1.2-3.5). A step up in mortality occurred around the third quintile corresponding with LVM-BSA 110 g/m(2) or LVM-Ht 51 g/m(2.7). Among the oldest old, elevated LVM is significantly associated with mortality.
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.|Department of Medicine, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Bursztyn
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.|Department of Medicine, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Leibowitz
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Irit
authors.initials: I
authors.lastname: Stessman-Lande
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.|Department of Rehabilitation and Geriatrics, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Jacobs
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Eliana
authors.initials: E
authors.lastname: Ein-Mor
authors.affiliation: Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.|Department of Rehabilitation and Geriatrics, Hadassah-Hebrew University Medical Center Mount-Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Jochanan
authors.initials: J
authors.lastname: Stessman
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001830:Body Surface Area; D015331:Cohort Studies; D004452:Echocardiography / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors