title: A CGH array study in nonsyndromic (primary) autism patients: deletions on 16p13.11, 16p11.2, 1q21.1, 2q21.1q21.2, and 8p23.1.
abstract: OBJECTIVE
  To detect specific molecular changes of DNA level in primary autism patients by using whole genome CGH array technology.
  
  
  METHODS
  A cohort of 35 primary autism patients received clinical genetic testing by using an oligonucleotide-based CGH array platform to test for submicroscopic genomic deletions and duplications. Fluorescent in situ hybridization was performed in seven patients for confirmation of the results.
  
  
  RESULTS
  We found 16p13.11 deletion in thirteen patients, 16p11.2 deletion in twelve patients, 1q21.1 deletion in ten patients, 2q21.1q21.2 deletion in eight patients, and 8p23.1 deletion in seven patients.
  
  
  CONCLUSIONS
  Our study indicates that genes in 16p13.11, 16p11.2, 1q21.1, 2q2l.1q21.2, and 8p23.1 loci are potential predisposition and new suspicious regions for primary autism. Deletion's in these regions should be investigated in further studies to understand pathogenesis of primary autism.
authors.forename: Kudret Esen
authors.initials: KE
authors.lastname: Gümüşlü
authors.forename: Hakan
authors.initials: H
authors.lastname: Savli
authors.forename: Deniz
authors.initials: D
authors.lastname: Sünnetçi
authors.forename: Naci
authors.initials: N
authors.lastname: Çine
authors.forename: Bülent
authors.initials: B
authors.lastname: Kara
authors.forename: Seda
authors.initials: S
authors.lastname: Eren Keskin
authors.forename: Ramis Ufuk
authors.initials: RU
authors.lastname: Akkoyunlu
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D055028:Comparative Genomic Hybridization / Q000379:methods*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014421:Turkey / Q000453:epidemiology