title: [Distribution characteristics and antimicrobial resistance of pathogens about hospital infection from patients in single hematology center during 2011 and 2013].
abstract: OBJECTIVE
  To analyze the characteristics of hospital infection of hematological disease, so as to provide reference for clinical therapy.
  
  
  METHODS
  Bacterial strains and antimicrobial resistance of patients with hospital infection in Department of Hematology, Peking University Third Hospital from Jan. 2011 to Dec. 2013 were identified and analyzed retrospectively. The specimens were from their blood, urine, sputum, throat swabs and etc.
  
  
  RESULTS
  Among the total of 168 isolates of bacteria,the majority of the bacteria strains were from sputum (42.9%); 114 (67.9%) bacteria strains were gram negative and 54 (32.1%) bacteria strains were gram positive; the pathogen testing showed that 20.8% were Pseudomonas aeruginosa,18.5% Escherichia coli,17.9% Staphylococcus aureus, 9.5% Klebsiellar pneumonia, 5.9% Staphylococcus epidermis and 27.4% other bacteria; The gram negative bacilli to cefepime, amikacin and carbapenems showed the lowest antimicrobial resistance rates, and S. aureus showed the lowest antimicrobial resistance rates to vancomycin and linezolid.
  
  
  CONCLUSIONS
  Patients with hemopathy are the main population of hospital infections, the gram negative bacteria are the most common pathogens.It is very important to promptly know the change in distribution of the pathogens in order to rationally select antibiotics and reduce the incidence of bacterial infections.
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Dong
authors.affiliation: Department of Clinical Laboratory, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Jing
authors.affiliation: Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Ke
mesh_terms: D000900:Anti-Bacterial Agents; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006405:Hematology; D006748:Hospital Departments; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents