title: Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex.
abstract: During growth and development, plants undergo a series of phase transitions from the juvenile-to-adult vegetative phase to the reproductive phase. In Arabidopsis, vegetative phase transitions and flowering are regulated by SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) factors. SPL mRNAs are post-transcriptionally regulated by miR156 in an age-dependent manner; however, the role of other mechanisms in this process is not known. In this study, we demonstrate that the HAG1/GCN5- and PRZ1/ADA2b-containing SAGA-like histone acetyltransferase (HAT) complex directly controls the transcription of SPLs and determines the time for juvenile-to-adult phase transition. Thus, epigenetic control by the SAGA-like HAT complex determines the transcriptional output of SPLs, which might be a prerequisite for the subsequent post-transcriptional regulation by miR156. Importantly, this epigenetic control mechanism is also crucial for miR156-independent induction of SPLs and acceleration of phase transition by light and photoperiod or during post-embryonic growth.
authors.affiliation: School of Biological Sciences, Seoul National University, Seoul, 151-747, Korea.
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Kim
authors.affiliation: School of Biological Sciences, Seoul National University, Seoul, 151-747, Korea.
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Oh
authors.affiliation: School of Biological Sciences, Seoul National University, Seoul, 151-747, Korea.|Plant Genomics and Breeding Institute, Seoul National University, Seoul, 151-742, Korea.
authors.forename: Yoo-Sun
authors.initials: YS
authors.lastname: Noh
authors.affiliation: Research Institute of Basic Sciences, Seoul National University, Seoul, 151-747, Korea.
authors.forename: Bosl
authors.initials: B
authors.lastname: Noh
mesh_terms: D017360:Arabidopsis / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D051548:Histone Acetyltransferases / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D000099224:p300-CBP-Associated Factor
chemical_list: D029681:Arabidopsis Proteins; D051548:Histone Acetyltransferases; D035683:MicroRNAs; D009687:Nuclear Proteins; D012097:Repressor Proteins; C559759:Mirn156 microRNA, Arabidopsis; C416221:SPL protein, Arabidopsis; C474636:GCN5 protein, Arabidopsis; D000099224:p300-CBP-Associated Factor
keywords: Arabidopsis thaliana; HAG1; SPLs; flowering; histone acetylation; phase transition