title: Substrate-anchored and degradation-sensitive anti-inflammatory coatings for implant materials.
abstract: Implant materials need to be highly biocompatible to avoid inflammation in clinical practice. Although biodegradable polymeric implants can eliminate the need for a second surgical intervention to remove the implant materials, they may produce acidic degradation products in vivo and cause non-bacterial inflammation. Here we show the strategy of "substrate-anchored and degradation-sensitive coatings" for biodegradable implants. Using poly(lactic acid)/hydroxyapatite as an implant material model, we constructed a layer-by-layer coating using pH-sensitive star polymers and dendrimers loaded with an anti-inflammatory drug, which was immobilised through a hydroxyapatite-anchored layer. The multifunctional coating can effectively suppress the local inflammation caused by the degradation of implant materials for at least 8 weeks in vivo. Moreover, the substrate-anchored coating is able to modulate the degradation of the substrate in a more homogeneous manner. The "substrate-anchored and degradation-sensitive coating" strategy therefore exhibits potential for the design of various self-anti-inflammatory biodegradable implant materials.
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Duo
authors.initials: D
authors.lastname: Wu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Xingyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Tianchan
authors.initials: T
authors.lastname: Chen
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Ding
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.|State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
authors.forename: Jianshu
authors.initials: J
authors.lastname: Li
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D017886:Durapatite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry / Q000494:pharmacology; D007279:Injections, Subcutaneous; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D020099:Coated Materials, Biocompatible; D050091:Dendrimers; D017886:Durapatite; D007213:Indomethacin; D053583:Interleukin-1beta; D015850:Interleukin-6; D019344:Lactic Acid; D011091:Polyesters; D011108:Polymers; D014409:Tumor Necrosis Factor-alpha; D000093242:Interleukin-6 Inhibitors; C104700:PAMAM Starburst; C033616:poly(lactide)