title: Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy.
abstract: We investigated the association between the clinical outcome and GSTP1 and XRCC1 gene polymorphisms in advanced NSCLC patients with cisplatin-based chemotherapy. We prospectively recruited 325 NSCLC patients between January 2010 and January 2014. Genotypes of GSTP1 A313G, XRCC1 Arg194Trp, Arg280His and Arg399Gln were conducted using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. AG and GG genotypes of GSTP1 A313G were correlated with a higher CR + PR when compared with AA genotype. Furthermore, GA and AA genotypes of XRCC1 Arg399Gln were associated with more CR + PR when compared with GG genotype. In the Cox proportional hazards model, GG genotype of GSTP1 A313G was significantly correlated with a longer median survival time when compared with AA genotype, and it is associated with a heavy decreased risk of death from NSCLC. Moreover, GA and AA genotypes of XRCC1 Arg399Gln had a significantly longer median survival time, and GA and AA genotypes were significantly associated with a moderate reduced risk of death from NSCLC. GSTP1 A313G and XRCC1 Arg399Gln gene polymorphisms might influence the response to cisplatin-based chemotherapy and affect the clinical outcome of advanced NSCLC.
authors.affiliation: Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University Guangzhou 510515, China ; Department of Thoracic Surgery, Affiliated People's Hospital of Inner Mongolia Medical University Hohhot 010020, China.
authors.forename: Bateer
authors.initials: B
authors.lastname: Han
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, China.
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, China.
authors.forename: Shirong
authors.initials: S
authors.lastname: Kang
authors.affiliation: Department of Thoracic Surgery, Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Affiliated People's Hospital of Inner Mongolia Medical University Hohhot 010020, China.
authors.forename: Qiyou
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University Guangzhou 510515, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016009:Chi-Square Distribution; D002945:Cisplatin / Q000627:therapeutic use*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D016016:Proportional Hazards Models; D011446:Prospective Studies; D065840:Protective Factors; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D002945:Cisplatin
keywords: GSTP1; XRCC1; cisplatin-based chemotherapy; non-small cell lung cancer; polymorphism