title: Morphological Versatility in the Self-Assembly of Val-Ala and Ala-Val Dipeptides.
abstract: Since the discovery of dipeptide self-assembly, diphenylalanine (Phe-Phe)-based dipeptides have been widely investigated in a variety of fields. Although various supramolecular Phe-Phe-based structures including tubes, vesicles, fibrils, sheets, necklaces, flakes, ribbons, and wires have been demonstrated by manipulating the external physical or chemical conditions applied, studies of the morphological diversity of dipeptides other than Phe-Phe are still required to understand both how these small molecules respond to external conditions such as the type of solvent and how the peptide sequence affects self-assembly and the corresponding molecular structures. In this work, we investigated the self-assembly of valine-alanine (Val-Ala) and alanine-valine (Ala-Val) dipeptides by varying the solvent medium. It was observed that Val-Ala dipeptide molecules may generate unique self-assembly-based morphologies in response to the solvent medium used. Interestingly, when Ala-Val dipeptides were utilized as a peptide source instead of Val-Ala, we observed distinct differences in the final dipeptide structures. We believe that such manipulation may not only provide us with a better understanding of the fundamentals of the dipeptide self-assembly process but also may enable us to generate novel peptide-based materials for various applications.
authors.affiliation: †Bio-inspired Materials Research Laboratory (BIMREL), Department of Chemistry, Gazi University, 06500 Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Erdogan
authors.affiliation: †Bio-inspired Materials Research Laboratory (BIMREL), Department of Chemistry, Gazi University, 06500 Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Babur
authors.affiliation: †Bio-inspired Materials Research Laboratory (BIMREL), Department of Chemistry, Gazi University, 06500 Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yilmaz
authors.affiliation: ‡Bionanodesign Laboratory, Department of Biomedical Engineering, TOBB University of Economics and Technology, 06560 Ankara, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Candas
authors.affiliation: §Theoretical/Computational Chemistry Research Laboratory, Department of Chemistry, Gazi University, 06900 Ankara, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Gordesel
authors.affiliation: §Theoretical/Computational Chemistry Research Laboratory, Department of Chemistry, Gazi University, 06900 Ankara, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Dede
authors.affiliation: ‡Bionanodesign Laboratory, Department of Biomedical Engineering, TOBB University of Economics and Technology, 06560 Ankara, Turkey.
authors.forename: Ersin Emre
authors.initials: EE
authors.lastname: Oren
authors.affiliation: ∥Department of Chemistry, Gazi University, Polatlı, 06500 Ankara, Turkey.
authors.forename: Gokcen Birlik
authors.initials: GB
authors.lastname: Demirel
authors.affiliation: ⊥Department of Physics, Gazi University, 06500 Ankara, Turkey.
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Ozturk
authors.affiliation: #Department of Metallurgy and Materials Engineering, Selcuk University, 42075 Konya, Turkey.
authors.forename: Mustafa Selman
authors.initials: MS
authors.lastname: Yavuz
authors.affiliation: †Bio-inspired Materials Research Laboratory (BIMREL), Department of Chemistry, Gazi University, 06500 Ankara, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Demirel
mesh_terms: D019840:2-Propanol / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D011725:Pyridines / Q000737:chemistry
chemical_list: D004151:Dipeptides; D011725:Pyridines; C026650:phenylalanylphenylalanine; D019840:2-Propanol; C023666:pyridine