title: Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy.
abstract: An α-tocopheryl succinate (α-TOS) containing diblock copolymer micellar system was used to deliver doxorubicin (Dox), an anticancer drug, for HCT116 colon cancer therapy. The α-TOS containing diblock copolymers were synthesized by conjugation of α-TOS molecules and a mPEG-b-PHEMA hydrophilic diblock copolymer by ester bonds. The Dox-loaded polymeric micelles were then obtained by solvent exchange process. In acidic surroundings such as endosomes or secondary lysosomes, the structures of the Dox-loaded polymeric micelles deformed and released the drug loads. Additionally, Dox-loaded polymeric micelles enhanced the cytotoxicity of Dox and α-TOS to cancer cells in vitro. Dox-loaded polymeric micelles also showed an exceptional tumor inhibiting effect in vivo. This study indicates that the α-TOS containing polymeric micelle system can be used as a drug carrier for cancer therapy.
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan.
authors.forename: Kuan-Yi
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan.
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Chiang
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan.
authors.forename: Ning-Yu
authors.initials: NY
authors.lastname: Hsu
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan.
authors.forename: Chieh-Yu
authors.initials: CY
authors.lastname: Yang
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan; Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang Ming University, Taipei 112, Taiwan; Biomedical Engineering Research Center, National Yang Ming University, Taipei 112, Taiwan. Electronic address: cllo@ym.edu.tw.
authors.forename: Chun-Liang
authors.initials: CL
authors.lastname: Lo
authors.affiliation: Taiwan Textile Research Institute, New Taipei City 23674, Taiwan.
authors.forename: Chen-An
authors.initials: CA
authors.lastname: Ku
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D024502:alpha-Tocopherol / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D008823:Micelles; D004317:Doxorubicin; D024502:alpha-Tocopherol
keywords: Cancer therapy; Doxorubicin; Intracellular drug delivery; Micelles; α-Tocopheryl succinate