title: A Shortcut to Activity-Dependent Transcription.
abstract: Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Harrison W
authors.initials: HW
authors.lastname: Gabel
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: meg@hms.harvard.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Greenberg
mesh_terms: D000818:Animals; D053903:DNA Breaks, Double-Stranded; D009474:Neurons / Q000378:metabolism*