title: Stability studies of cefoselis sulfate in the solid state.
abstract: The process of degradation was studied by using an HPLC-DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefoselis sulfate was investigated. In the solid state at increased RH the degradation of cefoselis sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland. Electronic address: pzalewski@ump.edu.pl.
authors.forename: Przemysław
authors.initials: P
authors.lastname: Zalewski
authors.affiliation: Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Skibiński
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Alicja
authors.initials: A
authors.lastname: Talaczyńska
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Paczkowska
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Garbacki
authors.affiliation: Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
authors.forename: Judyta
authors.initials: J
authors.lastname: Cielecka-Piontek
mesh_terms: D000388:Air; D002384:Catalysis; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D002511:Cephalosporins / Q000032:analysis*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006813:Humidity; D007700:Kinetics; D013431:Sulfates / Q000737:chemistry; D053719:Tandem Mass Spectrometry; D013696:Temperature; D013816:Thermodynamics; D000097572:Cefpirome; D000097586:Cefozopran
chemical_list: D015296:Ceftizoxime; D002511:Cephalosporins; D013431:Sulfates; D000097572:Cefpirome; D000097586:Cefozopran; C079769:cefoselis
keywords: Cefoselis sulfate; HPLC; Q-TOF; Stability in solid state