title: New 3,4-Secocycloartane and 3,4-Secodammarane Triterpenes from the Ecuadorian Plant Coussarea macrophylla.
abstract: Coussarea macrophylla (Mart.) Müll.Arg. (Rubiaceae) was collected in Ecuador, and the bark was extracted with AcOEt. Chromatographic separation afforded six novel 3,4-secocycloartane and 3,4-secodammarane triterpenes, named macrocoussaric acids A-F, together with the known metabolites secaubryenol and 3,4-secodammara-4(28),20,24-triene-3,26-dioic acid. The structures of the new compounds were determined on the basis of their spectroscopic data. This is the first report of 3,4-secocycloartane and 3,4-secodammarane triterpenes occurring in a Coussarea species. Macrocoussaric acids A and B (2 and 3, resp.) were found to be moderately cytotoxic against five different tumor cell lines.
authors.affiliation: Università degli Studi di Pavia, Dipartimento di Chimica and CISTRE, V.le Taramelli 12, IT-27100 Pavia (phone: +39 0382987322; fax: +39 0382987323).
authors.forename: Gianluca
authors.initials: G
authors.lastname: Gilardoni
authors.affiliation: Universidad Central del Ecuador, Escuela de Bioquimica y Farmacia, Facultad de Ciencias Quimicas, Quito, Ecuador.
authors.forename: Ximena
authors.initials: X
authors.lastname: Chiriboga
authors.affiliation: Università degli Studi di Pavia, Dipartimento di Chimica and CISTRE, V.le Taramelli 12, IT-27100 Pavia (phone: +39 0382987322; fax: +39 0382987323).
authors.forename: Paola
authors.initials: P
authors.lastname: Vita Finzi
authors.affiliation: Università degli Studi di Pavia, Dipartimento di Chimica and CISTRE, V.le Taramelli 12, IT-27100 Pavia (phone: +39 0382987322; fax: +39 0382987323). vidari@unipv.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
mesh_terms: D008968:Molecular Conformation; D019666:Rubiaceae / Q000737:chemistry*; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D012632:Secosteroids; D014315:Triterpenes; C000606492:macrocoussaric acid A; C000606493:macrocoussaric acid B
keywords: Coussarea macrophylla; Macrocoussaric acids A - F; Secocycloartane triterpenes; Secodammarane triterpenes; Triterpenes