title: A correlation of measles specific antibodies and the number of plasmacytoid dendritic cells is observed after measles vaccination in 9 month old infants.
abstract: Measles virus (MeV) represents one of the main causes of death among young children, particularly in developing countries. Upon infection, MeV controls both interferon induction (IFN) and the interferon signaling pathway which results in a severe host immunosuppression that can persists for up to 6 mo after infection. Despite the global biology of MeV infection is well studied, the role of the plasmacytoid dendritic cells (pDCs) during the host innate immune response after measles vaccination remains largely uncharacterized. Here we investigated the role of pDCs, the major producers of interferon in response to viral infections, in the development of adaptive immune response against MeV vaccine. We report that there is a strong correlation between pDCs population and the humoral immune response to Edmonston Zagreb (EZ) measles vaccination in 9-month-old mexican infants. Five infants were further evaluated after vaccination, showing a clear increase in pDCs at baseline, one week and 3 months after immunization. Three months postvaccination they showed increase in memory T-cells and pDCs populations, high induction of adaptive immunity and also observed a correlation between pDCs number and the humoral immune response. These findings suggest that the development and magnitude of the adaptive immune response following measles immunization is directly dependent on the number of pDCs of the innate immune response.
authors.affiliation: a Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México ; México City , México.
authors.forename: Miguel L
authors.initials: ML
authors.lastname: García-León
authors.forename: Laura C
authors.initials: LC
authors.lastname: Bonifaz
authors.forename: Bogart
authors.initials: B
authors.lastname: Espinosa-Torres
authors.forename: Brenda
authors.initials: B
authors.lastname: Hernández-Pérez
authors.forename: Lino
authors.initials: L
authors.lastname: Cardiel-Marmolejo
authors.forename: José I
authors.initials: JI
authors.lastname: Santos-Preciado
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Wong-Chew
mesh_terms: D056704:Adaptive Immunity / Q000276:immunology; D000328:Adult; D000367:Age Factors; D057134:Antibodies, Neutralizing / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis*; D002452:Cell Count; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology*; D008458:Measles Vaccine / Q000009:adverse effects / Q000276:immunology*; D008800:Mexico; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination; D010948:Viral Plaque Assay
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D008458:Measles Vaccine
keywords: (-) ssRNA, nonsegmented negative single-stranded RNA; DCs, dendritic cells; EZ, Edmonston Zagreb; GMT, Geometric mean titers; IFN, interferon; MMR, measles, mumps, rubella vaccine; MeV, Measles virus; PBMCs, peripheral blood mononuclear cells; PRN, plaque reduction neutralization; cellular and humoral immunity; mDCs, myeloid dendritic cells; measles vaccine; pDCs, plasmacytoid dendritic cells; plasmacytoid dendritic cells