title: The correlation of serum growth differentiation factor-15 level in patients with obstructive sleep apnea.
abstract: OBJECTIVE
  Growth differentiation factor-(GDF-) is a prognostic biomarker in cardiovascular disorders (CVD). GDF-15 level was not studied in patients with obstructive sleep apnea syndrome (OSAS) before. In this study, we investigated serum GDF-15 levels in OSAS patients and compared them with healthy controls.
  
  
  METHODS
  Polysomnographically, confirmed forty consecutive OSAS patients (20 men and 20 women) and forty consecutive healthy controls (23 men and 17 women) were enrolled in the study. The samples in each group had similar demographic characteristics and body mass index (BMI) values.
  
  
  RESULTS
  In the study, no significant correlation was found about GDF-15 levels of OSAS group and healthy controls. However, there was a significant statistical correlation between age and GDF-15 level. In correlation analysis, there was not any significant correlation between age and BMI.
  
  
  CONCLUSIONS
  Although various developing biomarkers have been studied in cardiovascular disorders, GDF-15 levels have attracted a widespread interest as predictors of cardiovascular risk. GDF-15 level has not been evaluated previously in patients with OSAS. A significant statistical correlation was found between age and GDF-15 level. To reveal close relation between OSAS and GDF-15, further studies are needed with combination of GDF-15 and other biomarkers in OSAS.
authors.affiliation: Otorhinolaryngology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Kamran
authors.initials: K
authors.lastname: Sari
authors.affiliation: Cardiology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ede
authors.affiliation: Otorhinolaryngology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Zeliha
authors.initials: Z
authors.lastname: Kapusuz Gencer
authors.affiliation: Otorhinolaryngology Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozkiris
authors.affiliation: Biochemistry Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Ayse Yesim
authors.initials: AY
authors.lastname: Gocmen
authors.affiliation: Chest Disease Department, Bozok University School of Medicine, 66200 Yozgat, Turkey.
authors.forename: Yavuz Selim
authors.initials: YS
authors.lastname: Intepe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: D015415:Biomarkers; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15