title: Fibrin sealant for mesh fixation in laparoscopic groin hernia repair does not increase long-term recurrence.
abstract: BACKGROUND
  Methods of groin hernia repair include laparoscopic techniques using tissue-penetrating mesh fixation or non-penetrating fixation. Concerns regarding hernia repair include postoperative chronic pain, sexual dysfunction, and recurrence. Earlier estimations of recurrence rates have largely been based on nationwide databases, where reoperation rates have been used as a surrogate measure for recurrence, which may underestimate the true recurrence rates. The aim of this study was to evaluate long-term recurrence in patients who had undergone transabdominal pre-peritoneal (TAPP) laparoscopic groin hernia repair using either fibrin sealant or tacks for mesh fixation.
  
  
  METHODS
  This study used data from the Danish Hernia Database to create the following cohort: All patients operated laparoscopically for primary groin hernia with a TAPP procedure using fibrin sealant for mesh fixation. These patients were matched 1:2 with patients, where the mesh was fixated using tacks. A validated questionnaire was sent to all included patients to determine recurrence, which was defined as reoperation or clinical diagnosis of recurrence by a physician. Follow-up was from index operation to either reoperation date, date of clinical recurrence diagnosis, or response date.
  
  
  RESULTS
  A total of 2273 persons (n = 2340 groins) were included, of which 1535 returned the questionnaire, resulting in a response rate of 66.2% with a median follow-up time of 31 months (range 0-62). Among these, 114 (7.4%) recurrences were found, of which 30 (5.8%) were in the fibrin sealant group and 84 (8.3%) in the tacks group (p = 0.084). The Cox regression analysis found no difference in recurrence with the use of tacks compared to fibrin sealant (hazard ratio 0.8) [95% CI (0.5-1.2)].
  
  
  CONCLUSIONS
  We found no significant difference in long-term reoperation rates and clinical recurrences in patients undergoing TAPP repair with meshes fixated with fibrin sealant compared with tacks.
authors.affiliation: Department of Surgery, Centre for Perioperative Optimization, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark. andreas_fenger@hotmail.com.
authors.forename: Andreas Qwist
authors.identifier: http://orcid.org/0000-0003-3250-234X
authors.initials: AQ
authors.lastname: Fenger
authors.affiliation: Department of Surgery, Centre for Perioperative Optimization, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
authors.forename: Neel Maria
authors.initials: NM
authors.lastname: Helvind
authors.affiliation: Department of Surgery, Centre for Perioperative Optimization, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Pommergaard
authors.affiliation: Department of Surgery, Centre for Perioperative Optimization, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
authors.forename: Jakob
authors.initials: J
authors.lastname: Burcharth
authors.affiliation: Department of Surgery, Centre for Perioperative Optimization, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.|The Danish Hernia Database, Copenhagen, Denmark.
authors.forename: Jacob
authors.initials: J
authors.lastname: Rosenberg
mesh_terms: D015331:Cohort Studies; D003718:Denmark; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D059685:Herniorrhaphy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D012008:Recurrence; D013526:Surgical Mesh; D011795:Surveys and Questionnaires
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics
keywords: Abdominal; Clinical papers; Clinical research; Clinical trials; Endoscopy; G-I; Hernia