title: Involvement of vascular endothelial growth factor -460 C/T, +405 G/C and +936 C/T polymorphisms in the development of endometriosis.
abstract: There are inconsistent data on the contribution of vascular endothelial growth factor (VEGF) -460 C/T (rs833061), +405 G/C (rs2010963) and +936 C/T (rs3025039) single-nucleotide polymorphisms (SNPs) to endometriosis in different ethnicities. Therefore, using high-resolution melting curve analysis, the present study examined the distribution of these SNPs in females with endometriosis-related infertility and a control group. None of the threeVEGFSNPs were associated with endometriosis-related infertility in the dominant and recessive models. The lowest P-values of the trend were observed for theVEGF+936 C/T (rs3025039) SNP in endometriosis-related infertility (Ptrend=0.149). Similarly, haplotype analyses ofVEGFSNPs did not demonstrate any SNP combination as a risk for endometriosis-related infertility, and the lowest overall P-values, P=0.141 and Pcorr=0.395, were observed for a haplotype (TGT) of the above SNPs. Taken together, these results did not demonstrate the contribution ofVEGFC/T, +405 G/C and +936 C/T SNPs to endometriosis-related infertility.
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań 60-781, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szczepańska
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60-781, Poland.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań 60-781, Poland ; Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60-781, Poland.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Wirstlein
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznań 60-781, Poland.
authors.forename: Jana
authors.initials: J
authors.lastname: Skrzypczak
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60-781, Poland.
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziłski
keywords: endometriosis; infertility; polymorphisms; vascular endothelial growth factor