title: Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications.
abstract: Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, NY 14627-0216, USA. nilsson@chem.rochester.edu.
authors.forename: Wathsala
authors.initials: W
authors.lastname: Liyanage
authors.forename: Kanika
authors.initials: K
authors.lastname: Vats
authors.forename: Annada
authors.initials: A
authors.lastname: Rajbhandary
authors.forename: Danielle S W
authors.initials: DS
authors.lastname: Benoit
authors.forename: Bradley L
authors.initials: BL
authors.lastname: Nilsson
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D032701:Biomimetics; D018929:Cell Culture Techniques / Q000379:methods*; D002470:Cell Survival; D004151:Dipeptides / Q000737:chemistry*; D005109:Extracellular Matrix / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology*; D020100:Hydrogels / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D041681:NIH 3T3 Cells; D057139:Nanofibers / Q000737:chemistry
chemical_list: D004151:Dipeptides; D020100:Hydrogels