title: Effects of a Preparation Containing Pantogam, Succinic Acid, and Chitosan on Activities of the Glutathione System and NADPH-Generating Enzymes in Rat Tissues under Conditions of Cerebral Ischemia/Reperfusion.
abstract: Treatment with the complex preparation containing pantogam, succinic acid, and chitosan normalized the concentration of reduced glutathione and activities of glutathione peroxidase, glutathione reductase, and some NADPH-generating enzymes (glucose-6-phosphate dehydrogenase and NADPH-isocitrate dehydrogenase) in animals with experimental hypoxia/reperfusion of the brain. These results can be explained by suppression of free radical oxidation and normalization of the antioxidant system related to the neuroprotective, antihypoxic, and antioxidant properties of these substances, their involvement into the regulation of cell metabolism under pathological conditions accompanied by oxidative stress.
authors.affiliation: Voronezh State University, Voronezh, Russia, solya333@mail.ru.
authors.forename: O A
authors.initials: OA
authors.lastname: Safonova
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.forename: A I
authors.initials: AI
authors.lastname: Slivkin
authors.forename: Yu
authors.initials: Y
authors.lastname: Talmi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications*; D048271:Chitosan / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005609:Free Radicals / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology; D013386:Succinates / Q000008:administration & dosage / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004338:Drug Combinations; D005609:Free Radicals; D013386:Succinates; C016030:pantogab; D010205:Pantothenic Acid; D009249:NADP; D005680:gamma-Aminobutyric Acid; D048271:Chitosan; D007521:Isocitrate Dehydrogenase; C039355:isocitrate dehydrogenase (NADP+); D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione