title: [The role of scintimammography with 99mTs-technetril to predict the pathologic status of regional lymph nodes in patients with locally advanced breast cancer after neoadjuvant chemotherapy].
abstract: The purpose of this study was to establish the role of scintimammography with 99mTs-technetril for predicting pathological status of regional lymph nodes after neoadjuvant chemotherapy. In 123 primary patients with locally advanced breast cancer stage cT1-4N0-3M0 there was performed scintimammography: before treatment and after 2-3 cycles of neoadjuvant chemotherapy 63 patients; after 2-3 cycles of neoadjuvant chemotherapy and before surgery--in 5 patients; after 4-6 cycles of neoadjuvant chemotherapy--55 women. All patients were divided into 2 groups: the first included 68 patients whom scintimammography was performed before and after 2-3 cycles of neoadjuvant chemotherapy; the second--60 women whom scintimammography was performed before treatment and before surgery. In patients of the first group positive results were obtained in 16 (23.5%), negative--26 (38.3%), false positive--16 (23.5%) and false negative--10 (14.7%) cases. Sensitivity, specificity, overall accuracy, positive predictive value and negative results were 61.5%, 61.9%, 61.7%, 50% and 72.2%, respectively. During the scintimammography after 4-6 cycles of neoadjuvant chemotherapy positive results were observed in 17 (28.3%) negative--18 (30%), false positive--19 (31.7%) and false negative--6 (10%) of patients. Thus, the sensitivity, specificity, overall accuracy, positive predictive value and negative results amounted to 73.9%, 48.6%, 58.3%, 47.2%, 75% respectively.
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Bryantseva
authors.forename: S V
authors.initials: SV
authors.lastname: Kanaev
authors.forename: V F
authors.initials: VF
authors.lastname: Semiglazov
authors.forename: S N
authors.initials: SN
authors.lastname: Novikov
authors.forename: P V
authors.initials: PV
authors.lastname: Krivorotko
authors.forename: V V
authors.initials: VV
authors.lastname: Klimenko
authors.forename: E S
authors.initials: ES
authors.lastname: Trufanova
authors.forename: Z S
authors.initials: ZS
authors.lastname: Kotova
authors.forename: A V
authors.initials: AV
authors.lastname: Chernaya
authors.forename: E A
authors.initials: EA
authors.lastname: Turkevich
authors.forename: T Yu
authors.initials: TY
authors.lastname: Semiglazova
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001365:Axilla; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D004334:Drug Administration Schedule; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D061305:Lymphoscintigraphy / Q000379:methods; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D017556:Technetium Compounds
chemical_list: D017556:Technetium Compounds