title: Silica Nanopills for Targeted Anticancer Drug Delivery.
abstract: Multifunctional SiO2 microtubes for targeted drug delivery are produced with precise control over shape and size by combining lithography and electrochemical etching. The hollow core is loaded with a lipophilic anticancer drug generating nanopills and an antibody is conjugated to the external surface for cancer cell targeting. Results demonstrate selective killing of neuroblastoma cells that express the cognate receptor.
authors.affiliation: Departament d'Enginyeria ElectrònicaElèctrica i Automàtica, Universitat Rovira i Virgili, Avda Països Catalans 26, Tarragona, 43007, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Alba
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, Mawson Lakes, SA, 5001, Australia.
authors.forename: Bahman
authors.initials: B
authors.lastname: Delalat
authors.affiliation: Departament d'Enginyeria ElectrònicaElèctrica i Automàtica, Universitat Rovira i Virgili, Avda Països Catalans 26, Tarragona, 43007, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Formentín
authors.affiliation: Department of Human Physiology, Centre for Neuroscience, Flinders University, Bedford Park, SA, 5042, Australia.
authors.forename: Mary-Louise
authors.initials: ML
authors.lastname: Rogers
authors.affiliation: Departament d'Enginyeria ElectrònicaElèctrica i Automàtica, Universitat Rovira i Virgili, Avda Països Catalans 26, Tarragona, 43007, Spain.
authors.forename: Lluís F
authors.initials: LF
authors.lastname: Marsal
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Mawson Institute, University of South Australia, Mawson Lakes, SA, 5001, Australia.
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D002166:Camptothecin / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D004563:Electrochemistry; D006801:Humans; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D008870:Microtubules / Q000737:chemistry; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000737:chemistry; D009447:Neuroblastoma / Q000188:drug therapy / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; D012822:Silicon Dioxide; D002166:Camptothecin
keywords: antibodies; cancer therapy; drug delivery; microtubes; porous silicon