title: Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China.
abstract: BACKGROUND
  Coxsackievirus A4 (CV-A4) is classified as human enterovirus A according to its serotype. CV-A4, an etiological agent of hand, foot, and mouth disease, affects children worldwide and can circulate in closed environments such as schools and hospitals for long periods.
  
  
  RESULTS
  An outbreak of febrile illness at a nursery school in Beijing, China, was confirmed to be caused by CV-A4. Phylogenetic analysis of the complete genome of the isolated strain showed that the virus belongs to the same cluster as the predominant CV-A4 strain in China. This outbreak was controlled by effective measures.
  
  
  CONCLUSIONS
  The early identification of the pathogen and timely intervention may be the most critical factors in controlling an outbreak caused by CV-A4 in a preschool.
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. lionalex@126.com.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Li
authors.affiliation: Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. xgdong1975@163.com.
authors.forename: Xiao-Gen
authors.initials: XG
authors.lastname: Dong
authors.affiliation: Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. alex2003@yeah.net.
authors.forename: Meng
authors.initials: M
authors.lastname: Qin
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. xiezhiping@126.com.
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Xie
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. gaohanchun@126.com.
authors.forename: Han-Chun
authors.initials: HC
authors.lastname: Gao
authors.affiliation: Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. wjkftcdc@163.com.
authors.forename: Jun-Yong
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. 285775687@qq.com.
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Yang
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. dandili@126.com.
authors.forename: Dan-Di
authors.initials: DD
authors.lastname: Li
authors.affiliation: Fengtai District Center for Disease Control and Prevention of Beijing, 3 Xi An St., Feng-Tai District, Beijing, 100071, China. lijie7111@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin St., Xuan-Wu District, Beijing, 100052, China. zhaojund@126.com.
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Duan
mesh_terms: D000068476:Beijing / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D004196:Disease Outbreaks; D004770:Enterovirus / Q000145:classification* / Q000302:isolation & purification*; D005260:Female; D005334:Fever / Q000209:etiology* / Q000821:virology; D006801:Humans; D007223:Infant; D017053:Infection Control / Q000379:methods; D008297:Male; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D012578:Schools, Nursery; D017422:Sequence Analysis, DNA
chemical_list: D012367:RNA, Viral