title: Pharmacokinetic Properties of a New Glutamic Acid Derivative Glutaron.
abstract: Inhomogenous distribution of glutaron in organs and tissues was found after intravenous and peroral administration: the agent demonstrated high affinity to organs with high degree of vascularization (lungs and heart) and elimination (kidney). Glutaron easily penetrates through the blood-brain barrier, which is consistent with its concentration in the adipose tissue.
authors.affiliation: Laboratory of Pharmacological Kinetics, Department of Pharmacology and Biopharmaceutics of the Faculty of Continuing Medical Education, Volgograd State Medical University, Volgograd, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Smirnova
authors.forename: A F
authors.initials: AF
authors.lastname: Ryabukha
authors.forename: K A
authors.initials: KA
authors.lastname: Kuznetsov
authors.forename: E A
authors.initials: EA
authors.lastname: Suchkov
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: I N
authors.initials: IN
authors.lastname: Tyurenkov
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002853:Chromatography, Liquid; D018698:Glutamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D014781:Viscera / Q000378:metabolism*
chemical_list: C581791:RGPU-135; D018698:Glutamic Acid