title: Improving the estimation of flavonoid intake for study of health outcomes.
abstract: Imprecision in estimating intakes of non-nutrient bioactive compounds such as flavonoids is a challenge in epidemiologic studies of health outcomes. The sources of this imprecision, using flavonoids as an example, include the variability of bioactive compounds in foods due to differences in growing conditions and processing, the challenges in laboratory quantification of flavonoids in foods, the incompleteness of flavonoid food composition tables, and the lack of adequate dietary assessment instruments. Steps to improve databases of bioactive compounds and to increase the accuracy and precision of the estimation of bioactive compound intakes in studies of health benefits and outcomes are suggested.
authors.affiliation: J.J. Peterson, J.T. Dwyer, and P.F. Jacques are with the Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer and P.F. Jacques are with the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer is with the Tufts University School of Medicine and Frances Stern Nutrition Center, Tufts Medical Center, Boston, Massachusetts, USA. M.L. McCullough is with the Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA. julia.peterson@tufts.edu.
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Peterson
authors.affiliation: J.J. Peterson, J.T. Dwyer, and P.F. Jacques are with the Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer and P.F. Jacques are with the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer is with the Tufts University School of Medicine and Frances Stern Nutrition Center, Tufts Medical Center, Boston, Massachusetts, USA. M.L. McCullough is with the Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: Johanna T
authors.initials: JT
authors.lastname: Dwyer
authors.affiliation: J.J. Peterson, J.T. Dwyer, and P.F. Jacques are with the Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer and P.F. Jacques are with the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer is with the Tufts University School of Medicine and Frances Stern Nutrition Center, Tufts Medical Center, Boston, Massachusetts, USA. M.L. McCullough is with the Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Jacques
authors.affiliation: J.J. Peterson, J.T. Dwyer, and P.F. Jacques are with the Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer and P.F. Jacques are with the Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA. J.T. Dwyer is with the Tufts University School of Medicine and Frances Stern Nutrition Center, Tufts Medical Center, Boston, Massachusetts, USA. M.L. McCullough is with the Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
authors.forename: Marjorie L
authors.initials: ML
authors.lastname: McCullough
mesh_terms: D016208:Databases, Factual; D005419:Flavonoids / Q000008:administration & dosage* / Q000032:analysis*; D005502:Food; D005504:Food Analysis; D006304:Health Status; D006801:Humans
chemical_list: D005419:Flavonoids
keywords: chemical analysis; databases; dietary assessment; dietary intakes; dietary supplements; flavonoids; food composition; food processing; phytochemicals; proanthocyanidins