title: [FGF23 and Klotho protein--the role in the pathogenesis of hypertension].
abstract: Fibroblast growth factor 23 (FGF23) is a relatively new phosphatonin, which is produced mainly by bone cells. It is responsible for the regulation of calcium- phosphate homeostasis in the body. FGF23 is one of hormones with phosphaturic effect. It inhibits renal reabsorbtion of phosphate and increases its urinary excretion. Moreover, FGF23 decreases serum concentration of 1,25(OH)2D by inhibition of lα-hydroxylase and stimulation of 24-hydroxylase. The current knowledge on FGF23 and its cofactor-Klotho protein in disturbances of calcium-phosphate balance or in Chronic Kidney Disease is quite obvious. Still we need to know more about the influence of FGF23 on the cardiovascular system and its role in the pathogenesis of hypertension thus this will be the main aspect of our study.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zając
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Rybi-Szumińska
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
mesh_terms: D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D000090265:Klotho Proteins; D010011:Osteocytes / Q000378:metabolism; D014807:Vitamin D / Q000097:blood
chemical_list: C000717427:FGF23 protein, human; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins