title: Cerebral autoregulation in pregnancies complicated by diabetes and overweight.
abstract: OBJECTIVE
  The aim of this study was to estimate the impact of diabetes and obesity on cerebral autoregulation in pregnancy.
  
  
  METHODS
  Cerebral autoregulation was evaluated in women with gestational diabetes, type 2 diabetes mellitus and/or overweight (body mass index ⩾ 25 kg m(-2)) and compared to a cohort of euglycaemic pregnant women. The autoregulation index was calculated using simultaneously recorded cerebral blood flow velocity in the middle cerebral artery and blood pressure. Autoregulation index values of 0 and 9 indicate absent and perfect autoregulation, respectively.
  
  
  RESULTS
  Autoregulation index in women with either diabetes (n = 33, 6.6 ± 1.1) or overweight (n = 21, 6.7 ± 0.6) was not significantly different to that in control patients (n = 23, 6.6 ± 0.8, p = 0.96).
  
  
  CONCLUSIONS
  Cerebral autoregulation is not impaired in pregnant women who have non-vasculopathic diabetes or overweight. This suggests that the increased risk of pre-eclampsia in diabetic and overweight women is not associated with early impaired cerebral autoregulation.
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA teelkien@gmail.com.
authors.forename: Teelkien R
authors.initials: TR
authors.lastname: van Veen
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Leicester, UK NIHR Biomedical Research Unit in Cardiovascular Sciences, Glenfield Hospital, Leicester, UK.
authors.forename: Ronney B
authors.initials: RB
authors.lastname: Panerai
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA St. David's Women's Center of Texas, North Austin Maternal-Fetal Medicine, Austin, TX, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Haeri
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Paul P
authors.initials: PP
authors.lastname: van den Berg
authors.affiliation: Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Gerda G
authors.initials: GG
authors.lastname: Zeeman
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Belfort
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D015992:Body Mass Index; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D050177:Overweight / Q000150:complications*; D011247:Pregnancy; D055815:Young Adult
keywords: Diabetes; cerebral autoregulation; overweight; pre-eclampsia; pregnancy