title: 17P deleted multiple myeloma presenting with intracranial disease: durable remission after tailored management.
abstract: In multiple myeloma (MM), del(17p) is associated with a poor outcome if present in greater than half the tumour cells. Similarly, intracranial involvement, often seen in the context of advanced disease, also heralds short survival. We present a rare case of MM presenting with intracranial disease and carrying del(17p) in 100% of tumour cells. This patient was successfully treated with combination chemotherapy employing central nervous system directed agents and bortezomib, followed by autologous stem cell transplant and consolidation with radiotherapy, bortezomib and thalidomide. We also present the outcomes of our single-centre experience of MM patients presenting with del(17p) disease. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Clinical Haematology, University College London NHS Foundation Trust, London, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Lee
authors.affiliation: Clinical Haematology, University College London NHS Foundation Trust, London, UK.
authors.forename: Dean
authors.initials: D
authors.lastname: Smith
authors.affiliation: Clinical Haematology, University College London NHS Foundation Trust, London, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Rabin
authors.affiliation: Clinical Oncology, University College London NHS Foundation Trust, London, UK.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tobias
authors.affiliation: Clinical Haematology, University College London NHS Foundation Trust, London, UK.
authors.forename: Kwee
authors.initials: K
authors.lastname: Yong
mesh_terms: D064592:Autografts; D000069286:Bortezomib / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000235:genetics / Q000628:therapy; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D060830:Consolidation Chemotherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000628:therapy; D058496:Smith-Magenis Syndrome / Q000235:genetics* / Q000628:therapy; D033581:Stem Cell Transplantation; D013792:Thalidomide / Q000008:administration & dosage*
chemical_list: D013792:Thalidomide; D000069286:Bortezomib
keywords: 17p deletion; bortezomib consolidation; intracranial myeloma; multiple myeloma