title: Silk fibroin for vascular regeneration.
abstract: Cardiovascular disease is the primary cause of morbidity and mortality in today's world. Due to the lack of healthy autologous vessels, more tissue-engineered blood vessels are needed to repair or replace the damaged arteries. Biomaterials play an indispensable role in creating a living neovessel with biological responses. Silk fibroin produced by silkworms possesses good cytocompatibility, tailorable biodegradability, suitable mechanical properties, and minimal inflammatory reactions. In addition, regenerated silk fibroin solutions can be processed into various forms of scaffolds such as films, fibers, tubes, and porous sponges. These features make silk fibroin a promising biomaterial for small-diameter vascular grafts. The present article focuses on the applications of silk fibroin for vascular regeneration. A brief overview of the properties of silk fibroin is provided, following which the current research status and future directions of the main types of silk fibroin scaffolds for vascular regeneration are reviewed and discussed. Microsc. Res. Tech. 80:280-290, 2017. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.
authors.forename: Danyan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, People's Republic of China.|National Research Center for Rehabilitation Technical Aids, Beijing, 100176, People's Republic of China.
authors.forename: Yubo
authors.initials: Y
authors.lastname: Fan
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D001807:Blood Vessel Prosthesis; D012831:Bombyx; D005349:Fibroins / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology; D047011:Silk; D023822:Tissue Engineering / Q000379:methods / Q000639:trends; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D047011:Silk; D005349:Fibroins
keywords: scaffold; silk fibroin; small-diameter vascular graft; vascular regeneration