title: Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection.
abstract: The pro-inflammatory cytokine interleukin (IL)-32 has gained much attention recently because of its important role in the inflammatory network. Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow. Recent studies have discovered the antiviral effects induced by IL-32 and its associated regulatory mechanisms. The interactions between IL-32 and various cytokines including cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interferon (IFN)-λ1, interleukin (IL)-6, and soluble IL-6 receptor have been described. This review aims to integrate these new findings into explicit concepts and raises the intriguing possibility of IL-32 as a therapeutic target.
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China. zhouyq1993@whu.edu.cn.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China. yingzhu@whu.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D053263:Gene Regulatory Networks; D054884:Host-Pathogen Interactions; D006801:Humans; D007378:Interleukins / Q000378:metabolism*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: C496971:IL32 protein, human; D007378:Interleukins
keywords: antiviral activities; interleukin-32; pro-inflammatory cytokine; virus infection