title: The first asymmetric total synthesis of lycoposerramine-R.
abstract: The first asymmetric total synthesis of lycoposerramine-R, a Lycopodium alkaloid possessing a novel skeleton, was accomplished by a strategy featuring the stereoselective intramolecular aldol cyclization giving a cis-fused 5/6 bicyclic skeleton and a new method for the construction of the pyridone ring via the aza-Wittig reaction.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. takayamah@faculty.chiba-u.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishida
authors.forename: Shinya
authors.initials: S
authors.lastname: Kimura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kogure
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D000470:Alkaloids; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D011728:Pyridones; C551369:lycoposerramine R