title: Sessile serrated adenoma/polyps with a depressed surface: a rare form of sessile serrated adenoma/polyp.
abstract: Sessile serrated adenoma/polyps (SSA/Ps) usually appear flat to sessile with a smooth-appearing surface. However, macroscopic appearances of SSA/P can vary from flat-elevated to nodular and can even show a pedunculated configuration as we previously reported. The aim of the current study was to evaluate the clinicopathologic features of another under-recognized form of SSA/P which shows a depressed surface. Among 634 cases of sessile serrated adenoma/polyp, a total of seven sessile serrated adenoma/polyps showing a depressed surface were identified in 6 patients during the review of endoscopic images between January 2013 and November 2013. One of these was found during the review of previous endoscopic images of the same patient. Patients were more often middle-aged to elderly men (83.3%) and had synchronous conventional adenomas and/or SSA/Ps except for one man. The polyps usually occurred in the proximal colon (71.4%) and the mean size of polyps was 9.3 mm (range; 6-13 mm). Most cases (71.4%) were of a flat-elevated type, and the remaining polyps (28.6%) were sessile. The majority of polyps (85.7%) showed a mucus cap. All but one of the cases (85.7%) showed BRAF-V600E mutations. Our findings are that SSA/Ps can show a central depression although such cases are rare. The endoscopic and clinicopathologic features of SSA/Ps showing a depressed surface appear to be similar to usual SSA/Ps except for the presence of a depressed surface and marked male preponderance. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1562070886167874 .
authors.affiliation: Department of Surgery, Daehang Hospital, Seoul, Republic of Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Lee
authors.affiliation: Department of Pathology, Daehang Hospital, 481-10 BangBae3-dong, Seocho-gu, 137-820, Seoul, Republic of Korea. mjkimdoc@gmail.com.
authors.forename: Mi-Jung
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Poongnap 2-Dong, Songpa-Gu, Seoul, 138-736, Republic of Korea.
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Chun
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Poongnap 2-Dong, Songpa-Gu, Seoul, 138-736, Republic of Korea.
authors.forename: Se-Jin
authors.initials: SJ
authors.lastname: Jang
authors.affiliation: Department of Surgery, Daehang Hospital, Seoul, Republic of Korea.
authors.forename: Do Sun
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Department of Surgery, Daehang Hospital, Seoul, Republic of Korea.
authors.forename: Doo Han
authors.initials: DH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Daehang Hospital, Seoul, Republic of Korea.
authors.forename: Eui Gon
authors.initials: EG
authors.lastname: Youk
mesh_terms: D018256:Adenomatous Polyps / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D001706:Biopsy; D003082:Colectomy; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D003111:Colonic Polyps / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D003113:Colonoscopy; D004252:DNA Mutational Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D047368:Tumor Burden
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf