title: A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor.
abstract: A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle in AR-governed phase. This triazole nucleoside therefore constitutes a novel structural paradigm and potential drug candidate for prostate cancer through inhibition of HSF1 and AR.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Menghua
authors.initials: M
authors.lastname: Wang
authors.forename: Eliana
authors.initials: E
authors.lastname: Beraldi
authors.forename: Mei
authors.initials: M
authors.lastname: Cong
authors.forename: Amina
authors.initials: A
authors.lastname: Zoubeidi
authors.forename: Martin
authors.initials: M
authors.lastname: Gleave
authors.affiliation: Innovative Drug Research Centre, Chongqing University, Chongqing, China. ling.peng@univ-amu.fr.
authors.forename: Ling
authors.initials: L
authors.lastname: Peng
mesh_terms: D045744:Cell Line, Tumor; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D006360:Heat-Shock Proteins; D011944:Receptors, Androgen; D014230:Triazoles