title: Yield of screening colonoscopy in renal transplant candidates.
abstract: BACKGROUND
  Cardiovascular disease is the most common cause of death among patients with end-stage renal disease undergoing maintenance dialysis. Renal transplantation offers a survival advantage to patients with end-stage renal disease; it is also associated with a three- to fivefold increase in the risk of developing a neoplasm.
  
  
  OBJECTIVE
  To determine the yield of screening colonoscopy among patients with chronic kidney disease who were considered for renal transplantation.
  
  
  METHODS
  Patients were included if they were ≥50 years of age, had chronic kidney disease and were being considered for renal transplantation. They underwent a screening colonoscopy that was performed as part of their pretransplant workup. Data from December 2008 to May 2014 were collected retrospectively for all eligible patients.
  
  
  RESULTS
  During the study period, 433 patients were considered for renal transplantation. Of these, 170 underwent colonoscopies as part of their pretransplant workup. One was excluded because of previous history of colon cancer. Of the 169 procedures performed, ≥1 polyp(s) was diagnosed in 24%. The most common pathological diagnoses were hyperplastic polyp or normal colonic tissue. Fifteen (37%) patients had tubular adenomas and one patient had a sessile serrated adenoma. Advanced adenomas, defined as villous, tubulovillous or high-grade dysplasia, were found in four patients. Adenocarcinoma was diagnosed in one patient.
  
  
  CONCLUSIONS
  In a population of asymptomatic potential kidney transplant recipients ≥50 years of age, the prevalence of colorectal adenomatous polyps was 24%. Colonoscopy appeared to be useful as a screening tool in potential transplant recipients.
authors.forename: Turki
authors.initials: T
authors.lastname: AlAmeel
authors.forename: Bahaa
authors.initials: B
authors.lastname: Bseiso
authors.forename: Meteb M
authors.initials: MM
authors.lastname: AlBugami
authors.forename: Sami
authors.initials: S
authors.lastname: AlMomen
authors.forename: Lee Stuart
authors.initials: LS
authors.lastname: Roth
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis*; D000236:Adenoma / Q000150:complications / Q000175:diagnosis*; D000368:Aged; D003111:Colonic Polyps / Q000150:complications / Q000175:diagnosis*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000150:complications / Q000175:diagnosis*; D015897:Comorbidity; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies