title: A model β-sheet interaction and thermodynamic analysis of β-strand mimetics.
abstract: β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using (1)H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.
authors.affiliation: Cancer Research UK Cancer Therapeutics Unit, Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, London, SM2 5NG, UK. keith.jones@icr.ac.uk.
authors.forename: Colin W
authors.initials: CW
authors.lastname: Robinson
authors.forename: Carl S
authors.initials: CS
authors.lastname: Rye
authors.forename: Nicola E A
authors.initials: NE
authors.lastname: Chessum
authors.forename: Keith
authors.initials: K
authors.lastname: Jones
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry; D018360:Crystallography, X-Ray; D010455:Peptides / Q000737:chemistry; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D013816:Thermodynamics
chemical_list: D010455:Peptides; D011506:Proteins