title: Applications of calixarenes in cancer chemotherapy: facts and perspectives.
abstract: Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. The anticancer activity of various functionalized calixarenes has been reported by several research groups. Due to their superior geometric shape, calixarenes can accommodate drug molecules by forming inclusion complexes. Controlled release of anticancer drugs by calixarenes might help in targeted chemotherapy. This review summarizes the anticancer potential of the calixarenes and their drug loading properties. The potential use of calixarenes in chemoradiotherapy is also highlighted in brief.
authors.affiliation: Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
authors.forename: Ali
authors.initials: A
authors.lastname: Yousaf
authors.affiliation: Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
authors.forename: Shafida Abd
authors.initials: SA
authors.lastname: Hamid
authors.affiliation: Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
authors.forename: Noraslinda M
authors.initials: NM
authors.lastname: Bunnori
authors.affiliation: Kulliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia.
authors.forename: A A
authors.initials: AA
authors.lastname: Ishola
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D047250:Calixarenes / Q000008:administration & dosage / Q000627:therapeutic use*; D059248:Chemoradiotherapy / Q000379:methods; D003692:Delayed-Action Preparations; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D047250:Calixarenes
keywords: calixarenes; cancer; chemotherapy