title: Soluble ST2 and troponin I combination: Useful biomarker for predicting development of stress cardiomyopathy in patients admitted to the medical intensive care unit.
abstract: OBJECTIVE
  Stress cardiomyopathy (SCM) sometimes develops in patients with non-cardiac medical illness. We hypothesized that soluble suppression of tumorigenicity 2 (sST2) can predict SCM.
  
  
  METHODS
  In 76 patients admitted to non-cardiac medical intensive care unit (MICU), echocardiography and sST2 were assessed on admission day (D0) and on the third day (D2). Cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP) were measured on D0.
  
  
  RESULTS
  The SCM group (21%, 16/76) showed significantly higher cTnI, BNP, sST2 (D2), and sST2 changes than the non-SCM group. In receiver operator characteristics curve analysis, they equally predicted SCM. In 65 patients with normal cTnI, sST2 (D2) and sST2 changes predicted SCM better than cTnI or BNP.
  
  
  CONCLUSIONS
  Follow-up sST2 and the change in sST2 have additional predictive value for SCM in patients with normal cTnI. A combination strategy of sST2 and cTnI would be useful to predict SCM in patients admitted to the MICU.
authors.affiliation: Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyun Suk
authors.initials: HS
authors.lastname: Yang
authors.affiliation: Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyoung Joon
authors.initials: HJ
authors.lastname: Shim
authors.affiliation: Department of Respiratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Sun Jong
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea. Electronic address: dearmina@hanmail.net.
authors.forename: Mina
authors.initials: M
authors.lastname: Hur
authors.affiliation: Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Di Somma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D003422:Critical Care; D005260:Female; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D000072179:Interleukin-1 Receptor-Like 1 Protein; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D011379:Prognosis; D012372:ROC Curve; D011956:Receptors, Cell Surface / Q000378:metabolism*; D054549:Takotsubo Cardiomyopathy / Q000175:diagnosis*; D019210:Troponin I / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface; D019210:Troponin I; D020097:Natriuretic Peptide, Brain
keywords: Biomarker; Prediction; Takotsubo cardiomyopathy; Troponin I; sST2