title: Normal Metabolic Levels in Prefrontal Cortex in Euthymic Bipolar I Patients with and without Suicide Attempts.
abstract: Introduction/Objective. Evidence suggests that the prefrontal cortex has been implicated in the pathophysiology of bipolar disorder (BD), but few neurochemical studies have evaluated this region in bipolar patients and there is no information from BD suicide attempters using Proton Magnetic Resonance Spectroscopy (H(+)MRS). The objective was to evaluate the metabolic function of the medial orbital frontal cortex in euthymic BD type I suicide and nonsuicide attempters compared to healthy subjects by H(+)MRS. Methods. 40 euthymic bipolar I outpatients, 19 without and 21 with history of suicide attempt, and 22 healthy subjects were interviewed using the Structured Clinical Interview with the DSM-IV axis I, the Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Barratt Impulsiveness Scale-11 and underwent H(+)MRS. Results. We did not find any metabolic abnormality in medial orbital frontal regions of suicide and nonsuicide BD patients and BD patients as a group compared to healthy subjects. Conclusions. The combined chronic use of psychotropic drugs with neuroprotective or neurotrophic effects leading to a euthymic state for longer periods of time may improve neurometabolic function, at least measured by H(+)MRS, even in suicide attempters. Besides, these results may implicate mood dependent alterations in brain metabolic activity. However, more studies with larger sample sizes of this heterogeneous disorder are warranted to clarify these data.
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: Marlos Vasconcelos
authors.initials: MV
authors.lastname: Rocha
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Nery-Fernandes
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: José Luiz
authors.initials: JL
authors.lastname: Guimarães
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: Lucas de Castro
authors.initials: Lde C
authors.lastname: Quarantini
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: Irismar Reis
authors.initials: IR
authors.lastname: de Oliveira
authors.affiliation: Image Memorial, Medicina Diagnóstica, Salvador, BA, Brazil.
authors.forename: Giovanna G
authors.initials: GG
authors.lastname: Ladeia-Rocha
authors.affiliation: Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Universidade Federal de São Paulo, 04021-001 São Paulo, SP, Brazil.
authors.forename: Andrea Parolin
authors.initials: AP
authors.lastname: Jackowski
authors.affiliation: Image Memorial, Medicina Diagnóstica, Salvador, BA, Brazil ; Department of Radiology, Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: César
authors.initials: C
authors.lastname: de Araujo Neto
authors.affiliation: Department of Neurosciences and Mental Health, Mood and Anxiety Disorders Program (CETHA), Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil ; Postgraduate Program in Medicine and Health, Universidade Federal da Bahia, 40110-905 Salvador, BA, Brazil.
authors.forename: Ângela
authors.initials: Â
authors.lastname: Miranda-Scippa
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D017397:Prefrontal Cortex / Q000378:metabolism*; D066244:Proton Magnetic Resonance Spectroscopy; D013406:Suicide, Attempted