title: [MODERN CONCEPT OF PATHOGENESIS OF ALLERGIC DISEASES AND NEW POTENTIALITIES OF IMMUNOTHERAPY].
abstract: Despite the undoubted success of specific immunotherapy of allergic diseases (desensitization), one should confess that its effectiveness is not always satisfactory, and this explains the ongoing search for new approaches to immunotherapy. This conclusion is based on the results of basic research in immunology and allergy which provide new opportunities for therapy. The analysis of relevant work related to the study of allergic processes makes it possible to allocate two items: 1) specific hyposensitization-therapeutic approach that is primarily aimed at the final stage of the allergic reaction development; 2) development of allergic phenotype begins at early stages of B lymphocyte development while its final stage, IgE hyperproduction, depends on multiple of pre- and accompanying factors. Unfortunately, we should say that there are many issues in the development of allergic reaction that are beyond our understanding. Nevertheless, today new mechanisms of pathogenesis are revealed and there is a real opportunity for new approaches to the treatment of this pathology. Some of such various mechanisms will be discussed below.
authors.affiliation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine; Peoples' Friendship University of Russia, Moscow, Russia; Institute of Immunophysiology, Moscow, Russia; National Institute of Allergology, Asthma and Clinical Immunology, Georgian National Academy of Sciences, Tskhaltubo, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Berezhnaya
authors.affiliation: R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine; Peoples' Friendship University of Russia, Moscow, Russia; Institute of Immunophysiology, Moscow, Russia; National Institute of Allergology, Asthma and Clinical Immunology, Georgian National Academy of Sciences, Tskhaltubo, Georgia.
authors.forename: R
authors.initials: R
authors.lastname: Sepiashvili
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D060151:B-Lymphocytes, Regulatory / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003888:Desensitization, Immunologic; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D007073:Immunoglobulin E / Q000276:immunology*; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E; D000094632:Thymic Stromal Lymphopoietin