title: [Effect of highly active anti-retroviral therapy on reducing HIV/AIDS related death in Hebei, 1989-2013].
abstract: OBJECTIVE
  To investigate the effect of highly active anti-retroviral therapy (HAART) on reducing HIV/AIDS related death.
  
  
  METHODS
  The analysis was conducted by using the data of 4,148 HIV/AIDS cases reported in Hebei province from 1989 to 2013. Regular follow-up, CD4 detection, registration of death were carried out for them. Free HAART has been provided to people living with HIV/AIDS who met the treatment requirement since 2003.
  
  
  RESULTS
  Of 4,148 HIV/AIDS cases, 12,451.48 person years were observed, 968 cases died due to all registered death causes. The death density was 7.77/100 person years. The death density was 2.87/100 person years for the HIV/AIDS cases receiving HAART, and 16.58/100 for the HIV/AIDS cases receiving no HAART. In 1,894 AIDS cases, a total of 4,774.48 person years were observed from onset to death, 581 cases died due to all registered death causes, and the death density was 121.69/100 person years. The death density was 4.77/100 person years for the cases receiving HAART, and 125.92/100 person years for the cases receiving no HAART. In the cases with CD less than 200/mm3, the death density was 22.9/100 person years for those receiving no HAART and 5.3/100 person years for those receiving HAART. The annual analysis found that the death rate due to all registered death causes declined as the increase of HAART coverage in people living with HIV/AIDS. The expanding of HAART coverage in people infected with HIV can reduce death rate among them.
  
  
  CONCLUSIONS
  Further expanding of HAART can effectively reduce the death among people living with HIV/AIDS.
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China; Email: chensuliang@sina.com.
authors.forename: Suliang
authors.initials: S
authors.lastname: Chen
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Xinli
authors.initials: X
authors.lastname: Lu
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Cuiying
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Hebei Provincial Key Discipline of Medical Virology, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China.
authors.forename: Hongru
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000401:mortality; D023241:Antiretroviral Therapy, Highly Active; D002423:Cause of Death / Q000639:trends; D002681:China / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy* / Q000401:mortality*; D006801:Humans; D016896:Treatment Outcome