title: An interactive web application for the dissemination of human systems immunology data.
abstract: BACKGROUND
  Systems immunology approaches have proven invaluable in translational research settings. The current rate at which large-scale datasets are generated presents unique challenges and opportunities. Mining aggregates of these datasets could accelerate the pace of discovery, but new solutions are needed to integrate the heterogeneous data types with the contextual information that is necessary for interpretation. In addition, enabling tools and technologies facilitating investigators' interaction with large-scale datasets must be developed in order to promote insight and foster knowledge discovery.
  
  
  METHODS
  State of the art application programming was employed to develop an interactive web application for browsing and visualizing large and complex datasets. A collection of human immune transcriptome datasets were loaded alongside contextual information about the samples.
  
  
  RESULTS
  We provide a resource enabling interactive query and navigation of transcriptome datasets relevant to human immunology research. Detailed information about studies and samples are displayed dynamically; if desired the associated data can be downloaded. Custom interactive visualizations of the data can be shared via email or social media. This application can be used to browse context-rich systems-scale data within and across systems immunology studies. This resource is publicly available online at [Gene Expression Browser Landing Page ( https://gxb.benaroyaresearch.org/dm3/landing.gsp )]. The source code is also available openly [Gene Expression Browser Source Code ( https://github.com/BenaroyaResearch/gxbrowser )].
  
  
  CONCLUSIONS
  We have developed a data browsing and visualization application capable of navigating increasingly large and complex datasets generated in the context of immunological studies. This intuitive tool ensures that, whether taken individually or as a whole, such datasets generated at great effort and expense remain interpretable and a ready source of insight for years to come.
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. cspeake@benaroyaresearch.org.
authors.forename: Cate
authors.initials: C
authors.lastname: Speake
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. spresnell@benaroyaresearch.org.
authors.forename: Scott
authors.initials: S
authors.lastname: Presnell
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. kdomico@gmail.com.
authors.forename: Kelly
authors.initials: K
authors.lastname: Domico
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. bzeitner@benaroyaresearch.org.
authors.forename: Brad
authors.initials: B
authors.lastname: Zeitner
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. abjork@benaroyaresearch.org.
authors.forename: Anna
authors.initials: A
authors.lastname: Bjork
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. dma36@columbia.edu.
authors.forename: David
authors.initials: D
authors.lastname: Anderson
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. mmason@benaroyaresearch.org.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mason
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. ewhalen@benaroyaresearch.org.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Whalen
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. ovargas@uw.edu.
authors.forename: Olivia
authors.initials: O
authors.lastname: Vargas
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. dpopov@benaroyaresearch.org.
authors.forename: Dimitry
authors.initials: D
authors.lastname: Popov
authors.affiliation: Sidra Medical and Research Center, Doha, Qatar. drinchai@sidra.org.
authors.forename: Darawan
authors.initials: D
authors.lastname: Rinchai
authors.affiliation: Aix-Marseille University, Marseille, France. Noemie.JOURDE@ap-hm.fr.
authors.forename: Noemie
authors.initials: N
authors.lastname: Jourde-Chiche
authors.affiliation: Department of Internal Medicine and Infectious Diseases, European Hospital, Marseille, France. laurentchiche@hotmail.com.
authors.forename: Laurent
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. cquinn@benaroyaresearch.org.
authors.forename: Charlie
authors.initials: C
authors.lastname: Quinn
authors.affiliation: Benaroya Research Institute, Systems Immunology Laboratory, 1201 Ninth Ave., Seattle, WA, 98101, USA. dchaussabel@sidra.org.|Sidra Medical and Research Center, Doha, Qatar. dchaussabel@sidra.org.
authors.forename: Damien
authors.initials: D
authors.lastname: Chaussabel
mesh_terms: D003627:Data Interpretation, Statistical; D019992:Databases as Topic; D006801:Humans; D007107:Immune System / Q000502:physiology*; D020407:Internet; D013223:Statistics as Topic; D049490:Systems Biology; D014584:User-Computer Interface