title: Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea.
abstract: Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). No compound showed significant activity (IC50 > 40 μM). Compound 1 showed moderate inhibitory activities against 11β-HSD1 (human IC50 = 13.1 μM; mouse IC50 = 91.8 μM).
authors.affiliation: a School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.|b School of Chemistry and Chemical Engineering, Ningxia Normal University , Guyuan 756000 , China.|c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Jian-Hai
authors.initials: JH
authors.lastname: Ding
authors.affiliation: a School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wei
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.affiliation: c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Ding
authors.affiliation: a School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: a School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan 430074 , China.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007527:Isoenzymes; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007527:Isoenzymes; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C000608876:trefoliol B; C000608877:trefoliol C; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1; C022616:thiazolyl blue
keywords: 11β-HSD; Tremella foliacea; cytotoxicities; trefoliols B and C