title: Monochromatic computed microtomography using laboratory and synchrotron sources and X-ray fluorescence analysis for comprehensive analysis of structural changes in bones.
abstract: A combination of X-ray tomography at different wavelengths and X-ray fluorescence analysis was applied in the study of two types of bone tissue changes: prolonged presence in microgravity conditions and age-related bone growth. The proximal tail vertebrae of geckos were selected for investigation because they do not bear the supporting load in locomotion, which allows them to be considered as an independent indicator of gravitational influence. For the vertebrae of geckos no significant differences were revealed in the elemental composition of the flight samples and the synchronous control samples. In addition, the gecko bone tissue samples from the jaw apparatus, spine and shoulder girdle were measured. The dynamics of structural changes in the bone tissue growth was studied using samples of a human fetal hand. The hands of human fetuses of 11-15 weeks were studied. Autonomous zones of calcium accumulation were found not only in individual fingers but in each of the investigated phalanges. The results obtained are discussed.
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation.
authors.forename: Alexey
authors.initials: A
authors.lastname: Buzmakov
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation ; Institute of Microelectronics Technology and High Purity Materials RAS , Moscow, Russian Federation.
authors.forename: Marina
authors.initials: M
authors.lastname: Chukalina
authors.affiliation: Institute for Information Transmission Problems (Kharkevich Institute) RAS , Moscow, Russian Federation.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Nikolaev
authors.affiliation: Research Institute of Human Morphology , Moscow, Russian Federation.
authors.forename: Victoriya
authors.initials: V
authors.lastname: Gulimova
authors.affiliation: Research Institute of Human Morphology , Moscow, Russian Federation.
authors.forename: Sergey
authors.initials: S
authors.lastname: Saveliev
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation.
authors.forename: Elena
authors.initials: E
authors.lastname: Tereschenko
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation.
authors.forename: Alexey
authors.initials: A
authors.lastname: Seregin
authors.affiliation: National Research Centre 'Kurchatov Institute' , Moscow, Russian Federation.
authors.forename: Roman
authors.initials: R
authors.lastname: Senin
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation.
authors.forename: Denis
authors.initials: D
authors.lastname: Zolotov
authors.affiliation: Department of Innovation and High Technology, Moscow Institute of Physics and Technology , Moscow, Russian Federation.
authors.forename: Victor
authors.initials: V
authors.lastname: Prun
authors.affiliation: Department of Computer Science, Loughborough University , Loughborough, UK.
authors.forename: Gerald
authors.initials: G
authors.lastname: Shaefer
authors.affiliation: Shubnikov Institute of Crystallography RAS , Moscow, Russian Federation.
authors.forename: Victor
authors.initials: V
authors.lastname: Asadchikov
keywords: X-ray fluorescence analysis; bone; monochromatic computed microtomography