title: Pretrial hippocampal θ-state differentiates single-unit response profiles during rabbit trace eyeblink conditioning.
abstract: Eyeblink conditioning given in the explicit presence of hippocampal θ results in accelerated learning and enhanced multiple-unit responses, with slower learning and suppression of unit activity under non-θ conditions. Recordings from putative pyramidal cells during θ-contingent training show that pretrial θ-state is linked to the probability of firing increases versus decreases rather than to the magnitude of such responses. These findings suggest that the learning facilitation during θ may be due to the recruitment of additional neurons that increase their firing rate during trials.
authors.affiliation: Department of Psychology and Center for Neuroscience, Miami University, Oxford, Ohio 45056, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Cicchese
authors.affiliation: Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Darling
authors.affiliation: Department of Psychology and Center for Neuroscience, Miami University, Oxford, Ohio 45056, USA berrysd@miamioh.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Berry
mesh_terms: D000200:Action Potentials; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D003215:Conditioning, Eyelid / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D013826:Theta Rhythm / Q000502:physiology*; D013997:Time Factors