title: [Treated with Artemether-Lumefantrine Five Evaluation of P. Falciparum Malaria Cases in Terms of Hyponatremia and Thrombocytopenia].
abstract: The most severe type of malaria, P. falciparum may progress with several complications. We have detected hyponatremia and thrombocytopenia in the cases with falciparum malaria. We have launched coartemether which is used in resistant falciparum and supportive care with our four cases. We found out hyponatremia in the cases because serum concentrations were between 117-134 mEq/L. Clinical conditions of the case were highly heavy, in which blood sodium level was pretty low. While the other three cases responded to the treatment in three days, this case responded after the fifth day. Owing to this situation, we thought that there was a relationship between the severity of hyponatremia and clinical course. We measured the number of blood platelet of three cases as 11000-65000-80000/mm3. There was no thrombocytopenia in other two cases. The patient with lowest blood sodium level had the lowest number of blood platelet, as well. With the help of coartemether and supportive care, thrombocytopenia recovered within three-five days in general, but in the patient with severe thrombocytopenia, it got better after the fifth day.
authors.affiliation: Şifa Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir, Türkiye. drerolsevim@hotmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Yalçın
authors.forename: Erol
authors.initials: E
authors.lastname: Sevim
authors.forename: Arzu
authors.initials: A
authors.lastname: Duran
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005449:Fluorenes / Q000627:therapeutic use*; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D000077549:Artemether; D000078102:Lumefantrine