title: First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain.
abstract: We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance.
authors.affiliation: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Pelaez
authors.affiliation: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Monteiro
authors.affiliation: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Rubio
authors.affiliation: Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Bouza
authors.affiliation: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gomez-Lopez
authors.affiliation: Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mellado
keywords: Aspergillus fumigatus; azole resistance spread; cyp51A; resistance mechanism