title: Validation of the Drug Abuse Screening Test (DAST-10): A study on illicit drug use among Chinese pregnant women.
abstract: We assessed the Chinese version of the Drug Abuse Screening Test (DAST-10) for identifying illicit drug use during pregnancy among Chinese population. Chinese pregnant women attending their first antenatal visit or their first unbooked visit to the maternity ward were recruited during a 4-month study period in 2011. The participants completed self-administered questionnaires on demographic information, a single question on illicit drug use during pregnancy and the DAST-10. Urine samples screened positive by the urine Point-of-Care Test were confirmed by gas chromatography-mass spectrometry. DAST-10 performance was compared with three different gold standards: urinalysis, self-reported drug use, and evidence of drug use by urinalysis or self-report. 1214 Chinese pregnant women participated in the study and 1085 complete DAST-10 forms were collected. Women who had used illicit drugs had significantly different DAST-10 scores than those who had not. The sensitivity of DAST-10 for identify illicit drug use in pregnant women ranged from 79.2% to 33.3% and specificity ranged from 67.7% to 99.7% using cut-off scores from ≥ 1 to ≥ 3. The ~ 80% sensitivity of DAST-10 using a cut-off score of ≥ 1 should be sufficient for screening of illicit drug use in Chinese pregnant women, but validation tests for drug use are needed.
authors.affiliation: Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Lap Po
authors.initials: LP
authors.lastname: Lam
authors.affiliation: Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Kowloon, Hong Kong SAR.
authors.forename: Wing Cheong
authors.initials: WC
authors.lastname: Leung
authors.affiliation: Department of Paediatrics &Adolescent Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong SAR.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ip
authors.affiliation: Department of Paediatrics &Adolescent Medicine, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Chun Bong
authors.initials: CB
authors.lastname: Chow
authors.affiliation: Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Mei Fung
authors.initials: MF
authors.lastname: Chan
authors.affiliation: Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Judy Wai Ying
authors.initials: JW
authors.lastname: Ng
authors.affiliation: Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Kowloon, Hong Kong SAR.
authors.forename: Chu
authors.initials: C
authors.lastname: Sing
authors.affiliation: Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Ying Hoo
authors.initials: YH
authors.lastname: Lam
authors.affiliation: Hospital Authority Toxicology Reference Laboratory, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Wing Lai Tony
authors.initials: WL
authors.lastname: Mak
authors.affiliation: Department of Obstetrics and Gynaecology, Princess Margaret Hospital, Laichikok, Hong Kong SAR.
authors.forename: Kam Ming
authors.initials: KM
authors.lastname: Chow
authors.affiliation: Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Kowloon, Hong Kong SAR.
authors.forename: Robert Kien Howe
authors.initials: RK
authors.lastname: Chin
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D013287:Illicit Drugs; D011247:Pregnancy; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods* / Q000592:standards*; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000453:epidemiology*
chemical_list: D013287:Illicit Drugs