title: Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study.
abstract: The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error?=?0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p?=?0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset =?1.01 (0.99-1.03), p?=?0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.
authors.affiliation: Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
authors.forename: Ann Sophie
authors.initials: AS
authors.lastname: Lønnberg
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
authors.forename: David Lorenzo
authors.initials: DL
authors.lastname: Duffy
authors.forename: Axel
authors.initials: A
authors.lastname: Skytthe
authors.forename: Kirsten Ohm
authors.initials: KO
authors.lastname: Kyvik
authors.forename: Ole Birger
authors.initials: OB
authors.lastname: Pedersen
authors.forename: Simon Francis
authors.initials: SF
authors.lastname: Thomsen
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D004200:Diseases in Twins / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D011446:Prospective Studies; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D014429:Twins, Dizygotic / Q000235:genetics*; D014430:Twins, Monozygotic / Q000235:genetics*; D055815:Young Adult