title: Effect of Carbamazepine and Valproate Monotherapy on Cardiovascular Risks in Epileptic Children.
abstract: OBJECTIVE
  We determined the effects of carbamazepine and valproic acid on the serum lipids and apolipoprotein A and B in epileptic children on long-term monotherapy and 3 months after drug discontinuation.
  
  
  METHODS
  Thirty-three epileptic children (17 boys, 16 girls, mean age 9.79 ± 2.5 years) were evaluated for serum lipids and lipoprotein results at the initiation of antiepileptic drug tapering and 3 months after cessation of antiepileptic therapy.
  
  
  RESULTS
  In the carbamazepine group (n = 13), there was no significant difference in the lipid profile at the end of therapy or at 3 months after the discontinuation, whereas in the valproate group (n = 20), triglycerides and apoprotein B and high-density lipoprotein cholesterol increased significantly 3 months after discontinuation. The ratios of total cholesterol:high-density lipoprotein improved but low-density lipoprotein:high-density lipoprotein and apolipoprotein:apolipoprotein remained unchanged.
  
  
  CONCLUSIONS
  Because these ratios are better predictor of atherosclerosis risk than the absolute values, the overall risk is not increased by the long-term use of carbamazepine and valproate.
authors.affiliation: Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi, India. Electronic address: deepikaharit@yahoo.com.
authors.forename: Deepika
authors.initials: D
authors.lastname: Harit
authors.affiliation: Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi, India.
authors.forename: Anju
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Department of Pediatrics, University College of Medical Sciences and GTB Hospital, Delhi, India.
authors.forename: Swati
authors.initials: S
authors.lastname: Kalra
authors.affiliation: Department of Neurochemistry, Institute of Human Behavior and Allied Sciences, Delhi, India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Chhillar
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001774:Blood Chemical Analysis; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012306:Risk; D062606:Tertiary Care Centers; D014280:Triglycerides / Q000097:blood; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002220:Carbamazepine; D014635:Valproic Acid
keywords: antiepileptic drugs; carbamazepine; lipid profile; pediatric epilepsy; valproate