title: Cellular and molecular mechanisms of chikungunya pathogenesis.
abstract: Chikungunya virus (CHIKV) is an arthropod-borne virus that causes chikungunya fever, a disease characterized by the onset of fever and rashes, with arthralgia as its hallmark symptom. CHIKV has re-emerged over the past decade, causing numerous outbreaks around the world. Since late 2013, CHIKV has reached the shores of the Americas, causing more than a million cases of infection. Despite concentrated efforts to understand the pathogenesis of the disease, further outbreaks remain a threat. This review highlights important findings regarding CHIKV-associated immunopathogenesis and offers important insights into future directions. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World."
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Fok-Moon
authors.initials: FM
authors.lastname: Lum
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A(∗)STAR), Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute of Infection and Global Health, University of Liverpool, United Kingdom. Electronic address: lisa_ng@immunol.a-star.edu.sg.
authors.forename: Lisa F P
authors.initials: LF
authors.lastname: Ng
mesh_terms: D065632:Chikungunya Fever / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D002646:Chikungunya virus / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D056724:Immunity, Humoral; D007113:Immunity, Innate
keywords: Chikungunya virus; Immune response; Immunopathogenesis; Pathology