title: Dolutegravir-based antiretroviral therapy in a severely overweight child with a multidrug-resistant human immunodeficiency virus infection. A case report and review.
abstract: The management of multidrug-resistant human immunodeficiency virus (MDR HIV) infections in children is particularly challenging due to the lack of experience with new drugs. Dolutegravir, combined with an optimized antiretroviral background therapy, is promising for the treatment of MDR HIV and has been approved recently for adults and adolescents. Data for children are extremely limited. We describe the efficacy, safety and plasmatic levels of a dolutegravir-based, complex active antiretroviral treatment regimen in a severely overweight 11-year-old child infected with an MDR HIV strain.
authors.affiliation: Department of Paediatrics, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: Wagner
authors.affiliation: Department of Paediatrics, Switzerland.
authors.forename: C A
authors.initials: CA
authors.lastname: Wyler-Lazarevic
authors.affiliation: Laboratory of Virology, Department of Genetics and Laboratory Medicine, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Yerly
authors.affiliation: Division of Clinical Pharmacology and Toxicology, University Hospitals of Geneva, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Samer
authors.affiliation: Department of Clinical Pharmaco-Toxicology, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Peytavin
authors.affiliation: Department of Paediatrics, Switzerland.
authors.forename: K M
authors.initials: KM
authors.lastname: Posfay-Barbe
authors.affiliation: Division of Infectious Diseases, Department of Medical Specialties, Geneva University, Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Calmy
authors.affiliation: Division of Infectious Diseases, Department of Medical Specialties, Geneva University, Geneva, Switzerland ; Infectious Diseases Department, Hospital-Clinic-IDIBAPS, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Ambrosioni
keywords: Children; T-20; dolutegravir; multidrug-resistant human immunodeficiency virus; rescue therapy