title: Primary intraventricular oligodendroglioma: A case report of the usefulness of Olig2 immunohistochemistry for diagnosis.
abstract: Primary intraventricular oligodendroglioma (IVO) is a rare form of clear cell neoplasm and diagnosis is challenging because other clear cell neoplasms such as central neurocytoma must be ruled out. We report a case of primary IVO in which Olig2 immunohistochemistry was useful for the diagnosis. A 33-year-old man was admitted to our hospital with severe headaches due to an intraventricular mass lesion and underwent total resection of the mass lesion. The histological diagnosis was oligodendroglioma because the tumor was negative for synaptophysin and positive for Olig2. IVO is rare and differential diagnoses must be considered. The correct pathologic diagnosis is essential for anticipating the prognosis and selecting adjuvant therapy. In this case, Olig2 was useful for the diagnosis of oligodendroglioma.
authors.affiliation: Department of Neurosurgery, Eisyokai Yoshida Hospital, Kobe, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsumoto
authors.affiliation: Department of Neurosurgery, Eisyokai Yoshida Hospital, Kobe, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D051792:Basic Helix-Loop-Helix Proteins / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D018306:Neurocytoma / Q000175:diagnosis; D000076104:Oligodendrocyte Transcription Factor 2; D009837:Oligodendroglioma / Q000175:diagnosis*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; C405708:OLIG2 protein, human
keywords: Olig 2; central neurocytoma; immunohistchemical staining; intraventricular; oligodendroglioma