title: Spontaneous remission of acromegaly and Cushing's disease following pituitary apoplexy: Two case reports.
abstract: In this double case report, we present two special cases of pituitary apoplexy. First, we describe a patient with growth hormone deficiency despite clinical suspicion of acromegaly. Imaging showed evidence of a recent pituitary apoplexy, which might have caused spontaneous remission of the acromegaly before presentation at our outpatient clinic. Second, we describe a patient who presented with spontaneous remission of Cushing's disease after pituitary apoplexy, followed by a spontaneous remission of a relapse of the Cushing's disease due to a second pituitary apoplexy. These cases show that patients in spontaneous remission of hormonally active pituitary adenomas should be suspected of a pituitary apoplexy. Furthermore, even after spontaneous remission following pituitary apoplexy, careful long-term follow-up of these patients is mandatory, as relapses of hormonal hypersecretion can occur.
authors.affiliation: Departments of Internal Medicine, Division of Endocrinology, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
authors.forename: S H P P
authors.initials: SH
authors.lastname: Roerink
authors.forename: E J
authors.initials: EJ
authors.lastname: van Lindert
authors.forename: A C
authors.initials: AC
authors.lastname: van de Ven
mesh_terms: D000172:Acromegaly / Q000503:physiopathology*; D000236:Adenoma / Q000473:pathology*; D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D047748:Pituitary ACTH Hypersecretion / Q000503:physiopathology*; D010899:Pituitary Apoplexy / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000473:pathology*; D012075:Remission, Spontaneous