title: A Personal History of Quadruplex-Small Molecule Targeting.
abstract: The story behind some of the early studies in the laboratory of Stephen Neidle on quadruplex-binding small molecules and the structural studies on quadruplexes and their complexes is presented and discussed in the context of his earlier work on drug-DNA interactions. More recent studies and future directions in the rational design of small molecules targeting telomeric and gene promoter quadruplexes are also described.
authors.affiliation: UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Neidle
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D055808:Drug Discovery; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D062105:Molecular Docking Simulation; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*; D016615:Telomere / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries; D004247:DNA
keywords: antitumor agents, crystal growth, DNA, drug discovery, G-quadruplexes