title: Effects of intravenous administration of tranexamic acid on hematological, hemostatic, and thromboelastographic analytes in healthy adult dogs.
abstract: OBJECTIVE
  To assess the effects of tranexamic acid (TA) on hematological, hemostatic, and thromboelastographic analytes in healthy adult dogs.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Eleven healthy, staff-owned, adult dogs.
  
  
  RESULTS
  Dogs were administered TA as an IV bolus, followed by a 3-hour constant rate infusion (CRI). Complete blood count, prothrombin time, activated partial thromboplastin time, D-dimer, antithrombin, fibrinogen, and thromboelastography (TEG) were measured prior to, and immediately after TA administration. Vomiting occurred transiently in the first 2 treated dogs, immediately after 20 and 15 mg/kg IV boluses, but not during the CRI. In all other dogs the TA IV bolus dose was reduced to 10 mg/kg, and administered slower, and vomiting did not occur. All measured hemostatic and hematological analytes remained within their reference intervals, however, following TA treatment, significant decreases were recorded in prothrombin time, TEG R and A30 values, Hct, and hemoglobin concentration, while the TEG LY30 significantly increased.
  
  
  CONCLUSIONS
  Administration of TA as a slow IV bolus at 10 mg/kg, followed by a 10 mg/kg/h CRI over 3 hours to healthy dogs is safe; however, its effect on TEG A30, A60, LY30, and LY60 values was inconsistent with its expected anti-fibrinolytic properties.
authors.affiliation: Departments of Small Animal Emergency and Critical Care, Rehovot, 76100, Israel.
authors.forename: Efrat
authors.initials: E
authors.lastname: Kelmer
authors.affiliation: Small Animal Internal Medicine, Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
authors.forename: Gilad
authors.initials: G
authors.lastname: Segev
authors.affiliation: The Human Blood Bank, Assaf Harofeh Medical Center, Tzrifin, Israel.
authors.forename: Victoria
authors.initials: V
authors.lastname: Papashvilli
authors.affiliation: The Human Blood Bank, Assaf Harofeh Medical Center, Tzrifin, Israel.
authors.forename: Naomi
authors.initials: N
authors.lastname: Rahimi-Levene
authors.affiliation: Departments of Small Animal Emergency and Critical Care, Rehovot, 76100, Israel.
authors.forename: Yaron
authors.initials: Y
authors.lastname: Bruchim
authors.affiliation: Small Animal Internal Medicine, Hebrew University Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, 76100, Israel.
authors.forename: Itamar
authors.initials: I
authors.lastname: Aroch
authors.affiliation: Departments of Small Animal Emergency and Critical Care, Rehovot, 76100, Israel.
authors.forename: Sigal
authors.initials: S
authors.lastname: Klainbart
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D000933:Antifibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001780:Blood Coagulation Tests / Q000662:veterinary; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D008297:Male; D011446:Prospective Studies; D011517:Prothrombin Time / Q000662:veterinary; D013916:Thrombelastography / Q000662:veterinary; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid; D005340:Fibrinogen
keywords: anti-fibrinolytic drugs; canine; coagulation; hematology; thromboelastography