title: Development and characterization of chitosan/hyaluronan film for transdermal delivery of thiocolchicoside.
abstract: The objective of this study was the development of chitosan/hyaluronan transdermal films to improve bioavailability of thiocolchicoside. This approach offers the possibility to elude the first-pass metabolism and at the same time it is able to provide a predictable and extended duration of activity. Films were prepared by casting and drying of aqueous solutions containing different weight ratios of chitosan and hyaluronan and characterized for their physico-chemical and functional properties. In accordance with polymeric composition of films and, therefore, with the amount of the net charge after the complexation, films containing the same weight ratio of chitosan and hyaluronan showed lower water uptake ability with respect to films containing only one polymeric species or an excess of chitosan or hyaluronan. Moreover, the lower the hydration of the polymeric network, the lower is the drug diffusion through the films and its permeation through the skin. This study clearly confirmed that the selection of a suitable polymeric weight ratio and appropriate preparative conditions allows the modulation of film functional properties, suggesting that these formulations could be used as a novel technological platform for transdermal drug delivery.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: federica.bigucci@unibo.it.
authors.forename: Federica
authors.initials: F
authors.lastname: Bigucci
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: angela.abruzzo2@unibo.it.
authors.forename: Angela
authors.initials: A
authors.lastname: Abruzzo
authors.affiliation: PolyCrystalLine srl, Via F.S. Fabri 127/1, 40059 Medicina, Bologna, Italy. Electronic address: bruno.saladini@polycrystalline.it.
authors.forename: Bruno
authors.initials: B
authors.lastname: Saladini
authors.affiliation: Department of Chemistry and Chemical Technology, University of Calabria, Via P. Bucci, Cubo 15D, 87036 Arcavacata di Rende, Cosenza, Italy. Electronic address: cate75@gmail.com.
authors.forename: Maria Caterina
authors.initials: MC
authors.lastname: Gallucci
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: teresa.cerchiara2@unibo.it.
authors.forename: Teresa
authors.initials: T
authors.lastname: Cerchiara
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: barbara.luppi@unibo.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Luppi
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D048271:Chitosan / Q000737:chemistry*; D003078:Colchicine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006820:Hyaluronic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D012867:Skin / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D034421:Sus scrofa; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D006820:Hyaluronic Acid; D048271:Chitosan; D003078:Colchicine; C004280:thiocolchicoside
keywords: Chitosan (PubMed CID: 71853); Chitosan/hyaluronan complexes; Hydrogels; Polymeric films; Sodium hyaluronate (PubMed CID: 3084049); Thiocolchicoside; Thiocolchicoside (PubMed CID 72067); Transdermal delivery