title: Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors.
abstract: Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydrase inhibitor (CAI) by means of kinetic, crystallographic and Raman spectroscopy studies, highlighting interesting results on its mechanism of action. These data can be exploited to design new, effective and selective CAIs.
authors.affiliation: Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy. anna.difiore@cnr.it gdesimon@unina.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Di Fiore
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vergara
authors.forename: Marco
authors.initials: M
authors.lastname: Caterino
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Alterio
authors.forename: Simona M
authors.initials: SM
authors.lastname: Monti
authors.forename: Joanna
authors.initials: J
authors.lastname: Ombouma
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Daniela
authors.initials: D
authors.lastname: Vullo
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Winum
authors.forename: Giuseppina
authors.initials: G
authors.lastname: De Simone
mesh_terms: D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000737:chemistry / Q000378:metabolism*; D020134:Catalytic Domain; D015195:Drug Design; D006801:Humans; D019811:Hydroxylamine / Q000737:chemistry* / Q000494:pharmacology; D062105:Molecular Docking Simulation; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D019811:Hydroxylamine; D002256:Carbonic Anhydrases