title: Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy.
abstract: OBJECTIVE
  The purpose of this study was to investigate whether the presence of tic disorder is negatively associated with sertraline (SRT) outcomes, but not with continued cognitive-behavioral therapy (CBT), in a sample of youth who were unresponsive to an initial full course of CBT.
  
  
  METHODS
  In the Nordic Long-Term OCD Study, children and adolescents with OCD who were rated as nonresponders to 14 weeks of open-label CBT were randomized to continued CBT (n=28) or SRT treatment (n=22) for an additional 16 weeks of treatment. We investigated whether the presence or absence of comorbid tic disorder moderated treatment outcomes on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS).
  
  
  RESULTS
  Twelve out of 50 (24.0%) participants were diagnosed with comorbid tic disorder, with 7 receiving continued CBT and 5 receiving SRT, respectively. In patients without tic disorder, results showed no significant between-group differences on average CY-BOCS scores. However, in patients with comorbid tic disorder, those who received SRT had significantly lower average CY-BOCS scores than those who received continued CBT.
  
  
  CONCLUSIONS
  Children and adolescents with OCD and comorbid tic disorder, who are nonresponders to an initial 14 week course of CBT, may benefit more from a serotonin reuptake inhibitor (SRI) than from continued CBT.
authors.affiliation: 1 Center for Child and Adolescent Mental Health , Eastern and Southern Norway, Oslo, Norway .
authors.forename: Gudmundur
authors.initials: G
authors.lastname: Skarphedinsson
authors.affiliation: 2 Duke University Medical Center Department of Psychiatry , Durham, North Carolina.
authors.forename: Scott
authors.initials: S
authors.lastname: Compton
authors.affiliation: 3 Aarhus University Hospital , Centre for Child and Adolescent Psychiatry, Risskov, Denmark .
authors.forename: Per Hove
authors.initials: PH
authors.lastname: Thomsen
authors.affiliation: 4 Norwegian University of Science and Technology , Faculty of Medicine, Regional Center for Child and Youth Mental Health and Child Welfare, Trondheim, Norway .
authors.forename: Bernhard
authors.initials: B
authors.lastname: Weidle
authors.affiliation: 1 Center for Child and Adolescent Mental Health , Eastern and Southern Norway, Oslo, Norway .
authors.forename: Kitty
authors.initials: K
authors.lastname: Dahl
authors.affiliation: 3 Aarhus University Hospital , Centre for Child and Adolescent Psychiatry, Risskov, Denmark .
authors.forename: Judith Becker
authors.initials: JB
authors.lastname: Nissen
authors.affiliation: 1 Center for Child and Adolescent Mental Health , Eastern and Southern Norway, Oslo, Norway .|5 Department of Child and Adolescent Psychiatry, Division of Mental Health and Addiction, Vestre Viken Hospital , Drammen, Norway .
authors.forename: Nor Christian
authors.initials: NC
authors.lastname: Torp
authors.affiliation: 3 Aarhus University Hospital , Centre for Child and Adolescent Psychiatry, Risskov, Denmark .
authors.forename: Katja
authors.initials: K
authors.lastname: Hybel
authors.affiliation: 6 OCD-Clinic, Queen Silvia Children's Hospital, Sahlgrenska University Hospital , Gothenburg, Sweden .
authors.forename: Karin Holmgren
authors.initials: KH
authors.lastname: Melin
authors.affiliation: 4 Norwegian University of Science and Technology , Faculty of Medicine, Regional Center for Child and Youth Mental Health and Child Welfare, Trondheim, Norway .
authors.forename: Robert
authors.initials: R
authors.lastname: Valderhaug
authors.affiliation: 1 Center for Child and Adolescent Mental Health , Eastern and Southern Norway, Oslo, Norway .|7 Centre for Violence and Traumatic Stress Studies , Oslo, Norway.
authors.forename: Tore
authors.initials: T
authors.lastname: Wentzel-Larsen
authors.affiliation: 3 Aarhus University Hospital , Centre for Child and Adolescent Psychiatry, Risskov, Denmark .
authors.forename: Tord
authors.initials: T
authors.lastname: Ivarsson
mesh_terms: D000293:Adolescent; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D020280:Sertraline / Q000627:therapeutic use*; D013981:Tic Disorders / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline