title: Association of Elevated Serum Uric Acid with the Components of Metabolic Syndrome and Oxidative Stress in Abdominal Obesity Subjects.
abstract: Abdominal obesity (AO) and metabolic syndrome (MetS) are associated with the cardiovascular disease and type 2 diabetes. Serum uric acid (SUA) is often elevated in subjects with the AO. We aimed to investigate the association of elevated SUA with the components of MetS, oxidative stress and TG/HDL-C ratio in AO subjects. This cross-sectional study used data from a Health Survey for Prevention of Hypertension and Type 2 Diabetes Mellitus in residents of two districts in Phitsanulok province, including 443 subjects. Anthropometric, blood pressure (BP) and biochemical variables were measured. We categorized the participants to two-group as 248 AO subjects (median age = 58, interquartile range 50.0-65.0 years) and 195 non-AO subjects (median age = 53, interquartile range 47.0-62.0 years). Waist circumference was significantly correlated with SystBP, DiastBP, Glu and SUA (P < 0.05) and SUA was significantly correlated with Glu, TG, HDL-C and TG/HDL-C ratio (P < 0.05). By using multiple logistic regression, we found the association of elevated SUA with abdominal obesity, hyperglycemia, hypertriglyceridemia, reduced HDL-C, elevated TG/HDL-C ratio, MetS and increased oxidative stress after adjusting for their covariates. Our study demonstrated that circulating UA is a major antioxidant and might help protect against free-radical oxidative damage. However, elevated SUA concentrations associated with oxidative stress, MetS, insulin resistance, and components of MetS. Then, SUA may be a marker of increased oxidative stress, insulin resistance and MetS, implying an increased risk of vascular disease and T2DM.
authors.affiliation: Department of Community Occupational Family Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, 65000 Thailand.
authors.forename: Patcharin
authors.initials: P
authors.lastname: Pingmuangkaew
authors.affiliation: Geriatric Research Group, Department of Medical Technology, Faculty of Allied Health Sciences, Nareuan University, Phitsanulok, 65000 Thailand.
authors.forename: Orathai
authors.initials: O
authors.lastname: Tangvarasittichai
authors.affiliation: Geriatric Research Group, Department of Medical Technology, Faculty of Allied Health Sciences, Nareuan University, Phitsanulok, 65000 Thailand ; Chronic Disease Research Unit, Department of Optometry, Faculty of Allied Health Sciences, NareSUAn University, Phitsanulok, 65000 Thailand.
authors.forename: Surapon
authors.initials: S
authors.lastname: Tangvarasittichai
keywords: Abdominal obesity; Metabolic syndrome; Oxidative stress; TG/HDL-C ratio; Uric acid