title: Is there a difference in progression of renal disease between South Asian and white European diabetic adults with moderately reduced kidney function?
abstract: OBJECTIVE
  We examined potential ethnicity-related differences in progression of chronic kidney disease (CKD) between South Asian and white European diabetic adults with CKD stage 3 over a 5-year period.
  
  
  METHODS
  We analysed data collected from diabetic adults of white European and South Asian ethnicity who had attended diabetes and diabetes-renal outpatient clinics with baseline estimated glomerular filtration rate (eGFR) values ≥30 and <60 ml/min/1.73 m(2) over 5 years (2005-2010); 891 (76%) were white Europeans, 282 (24%) were South Asians.
  
  
  RESULTS
  Despite similar baseline eGFR (P=0.103), South Asians were younger [median (interquartile range) 68 (63-73) vs. 70 (64-77) years; P<0.001] and had worse baseline glycated haemoglobin than white Europeans [8.0 (7.0-9.1) vs. 7.6 (6.8-8.7)%; P=0.004]. The 5-year follow-up eGFR and the decline in eGFR did not differ between the two groups. Thirty-five (12.4%) South Asians and 82 (9.2%) white Europeans progressed to stages 4-5 CKD (P=0.112). There was a trend towards higher follow-up glycated haemoglobin levels in South Asians (P=0.064).
  
  
  CONCLUSIONS
  Despite worse glycaemic control, South Asian diabetic adults with CKD stage 3 did not show any difference in 5-year decline in eGFR compared with white Europeans. These data do not support ethnic differences in progression of CKD between the South Asian and white European patient populations.
authors.affiliation: Renal Unit, Heartlands Hospital, Bordesley Green East, Birmingham, UK; Department of Human Physiology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Slovak Republic.
authors.forename: Maria
authors.initials: M
authors.lastname: Pallayova
authors.affiliation: Renal Unit, Heartlands Hospital, Bordesley Green East, Birmingham, UK.
authors.forename: Hugh
authors.initials: H
authors.lastname: Rayner
authors.affiliation: Department of Medicine and Clinical Research Core, Weill Cornell Medical College - Qatar, Doha, Qatar; Specialist Weight Management Service and Diabetes Centre, Hamad Medical Corporation, Doha, Qatar; Department of Medicine, King's College London, London, UK.
authors.forename: Shahrad
authors.initials: S
authors.lastname: Taheri
authors.affiliation: Renal Unit, Heartlands Hospital, Bordesley Green East, Birmingham, UK. Electronic address: indranil.dasgupta@heartofengland.nhs.uk.
authors.forename: Indranil
authors.initials: I
authors.lastname: Dasgupta
mesh_terms: D000368:Aged; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000208:ethnology*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology / Q000208:ethnology*; D012307:Risk Factors; D044465:White People
keywords: Chronic kidney disease; Diabetes mellitus; Estimated glomerular filtration rate; Ethnicity; Glycated haemoglobin