title: Influence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Disease.
abstract: OBJECTIVE
  This study sought to evaluate the effect of liver transplantation on the neuropsychological manifestations of Wilson disease.
  
  
  METHODS
  Nine of 42 Wilson disease patients had neuropsychological symptoms before liver transplantation. They were 7 male and 2 female subjects with a median age of 19 years (range 10 to 25). They were analyzed for their preoperative and postoperative hepatic, neurological, and psychological scores described by the Unified Wilson Disease Rating Scale after a mean 36.6 months of follow-up.
  
  
  RESULTS
  Preoperative mean Model for End-Stage Liver Disease and Child-Pugh scores were 18.3 (range 15 to 26) and 8.9 (range 6 to 12), respectively. One patient had acute postoperative ischemic stroke unrelated to Wilson disease and was excluded from the statistical analysis. Preoperative and postoperative hepatic, neurological, and psychological scores of the remaining 8 patients were 7.4 ± 2.3 vs 2.4 ± 1.3 (P = .0005), 17.7 ± 11.7 vs 12.7 ± 12.5 (P = .055), and 9.0 ± 1.7 vs 7.0 ± 2.1 (P = .033).
  
  
  CONCLUSIONS
  Liver transplantation for Wilson disease can provide some improvement of the neuropsychological symptoms in addition to the hepatic recovery.
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. Electronic address: maliyagci@gmail.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Yagci
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Tardu
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Karagul
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Ertugrul
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Ince
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Kirmizi
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Unal
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Isik
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Kayaalp
authors.affiliation: Department of Surgery, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D002648:Child; D058625:End Stage Liver Disease / Q000150:complications / Q000601:surgery*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000523:psychology*; D006801:Humans; D016031:Liver Transplantation / Q000523:psychology*; D008297:Male