title: Preliminary evidence of reduced brain network activation in patients with post-traumatic migraine following concussion.
abstract: Post-traumatic migraine (PTM) (i.e., headache, nausea, light and/or noise sensitivity) is an emerging risk factor for prolonged recovery following concussion. Concussions and migraine share similar pathophysiology characterized by specific ionic imbalances in the brain. Given these similarities, patients with PTM following concussion may exhibit distinct electrophysiological patterns, although researchers have yet to examine the electrophysiological brain activation in patients with PTM following concussion. A novel approach that may help differentiate brain activation in patients with and without PTM is brain network activation (BNA) analysis. BNA involves an algorithmic analysis applied to multichannel EEG-ERP data that provides a network map of cortical activity and quantitative data during specific tasks. A prospective, repeated measures design was used to evaluate BNA (during Go/NoGo task), EEG-ERP, cognitive performance, and concussion related symptoms at 1, 2, 3, and 4 weeks post-injury intervals among athletes with a medically diagnosed concussion with PTM (n = 15) and without (NO-PTM) (n = 22); and age, sex, and concussion history matched controls without concussion (CONTROL) (n = 20). Participants with PTM had significantly reduced BNA compared to NO-PTM and CONTROLS for Go and NoGo components at 3 weeks and for NoGo component at 4 weeks post-injury. The PTM group also demonstrated a more prominent deviation of network activity compared to the other two groups over a longer period of time. The composite BNA algorithm may be a more sensitive measure of electrophysiological change in the brain that can augment established cognitive assessment tools for detecting impairment in individuals with PTM.
authors.affiliation: Department of Orthopaedic Surgery/UPMC Sports Medicine Concussion Program, University of Pittsburgh, 3200 South Water St, Pittsburgh, PA, 15203, USA. akontos@pitt.edu.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Kontos
authors.affiliation: ElMindA, Ltd, Tel Aviv, Israel.
authors.forename: Amit
authors.initials: A
authors.lastname: Reches
authors.affiliation: Department of Health, Human Performance and Recreation/Office for Sport Concussion Research, University of Arkansas, Fayetteville, AR, 72701, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Elbin
authors.affiliation: ElMindA, Ltd, Tel Aviv, Israel.
authors.forename: Dalia
authors.initials: D
authors.lastname: Dickman
authors.affiliation: ElMindA, Ltd, Tel Aviv, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Laufer
authors.affiliation: ElMindA, Ltd, Tel Aviv, Israel.
authors.forename: Amir B
authors.initials: AB
authors.lastname: Geva
authors.affiliation: ElMindA, Ltd, Tel Aviv, Israel.
authors.forename: Galit
authors.initials: G
authors.lastname: Shacham
authors.affiliation: Department of Orthopaedic Surgery/UPMC Sports Medicine Concussion Program, University of Pittsburgh, 3200 South Water St, Pittsburgh, PA, 15203, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: DeWolf
authors.affiliation: Department of Orthopaedic Surgery/UPMC Sports Medicine Concussion Program, University of Pittsburgh, 3200 South Water St, Pittsburgh, PA, 15203, USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Collins
mesh_terms: D000293:Adolescent; D000465:Algorithms; D056352:Athletes; D001265:Athletic Injuries / Q000150:complications; D001921:Brain / Q000503:physiopathology; D001924:Brain Concussion / Q000150:complications; D003071:Cognition / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000503:physiopathology*; D009483:Neuropsychological Tests; D038223:Post-Concussion Syndrome / Q000378:metabolism / Q000503:physiopathology*; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Brain network activation; Electroencephalography; Post-traumatic migraine; Sport-related concussion