title: Severe Neonatal Pertussis Treated by Leukodepletion and Early Extra Corporeal Membrane Oxygenation.
abstract: We report the case of a 17-day-old infant with severe pertussis for whom the early initiation of veno-arterial extra corporeal membrane oxygenation and leukodepletion strategies (exchange transfusion and leukofiltration) allowed to reduce leukocytosis and pulmonary hypertension, thus leading to survival. These invasive techniques can be considered when severe pulmonary hypertension complicates hyperleukocytosis in neonates.
authors.affiliation: From the Pediatric Cardiology Intensive Care Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France.
authors.forename: Jana
authors.initials: J
authors.lastname: Assy
authors.forename: Pierre-Emmanuel
authors.initials: PE
authors.lastname: Séguéla
authors.forename: Elodie
authors.initials: E
authors.lastname: Guillet
authors.forename: Philippe
authors.initials: P
authors.lastname: Mauriat
mesh_terms: D002675:Child, Preschool; D005078:Exchange Transfusion, Whole Blood; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000628:therapy*; D007231:Infant, Newborn; D047589:Leukocyte Reduction Procedures; D007964:Leukocytosis / Q000628:therapy*; D016896:Treatment Outcome; D014917:Whooping Cough / Q000150:complications* / Q000628:therapy*