title: Association between high-sensitivity troponin T, left ventricular hypertrophy, and myocardial performance index.
abstract: BACKGROUND
  The prognostic importance of high-sensitivity cardiac troponin T (hs-cTnT) has recently been reported in patients with heart failure. The myocardial performance index (MPI), which combines parameters of both systolic and diastolic ventricular function, provides a better marker of left ventricular dysfunction in hypertensive patients with preserved left ventricular ejection fraction (LVEF).
  
  
  OBJECTIVE
  We aimed to investigate the relationship between hs-cTnT and tissue Doppler-derived MPI in newly diagnosed hypertensive patients with preserved LVEF.
  
  
  METHODS
  We studied 306 patients with newly diagnosed hypertension. The patients were divided into two groups according to their median MPI values: MPIlo and MPIhigh groups. The MPI was calculated from the pulsed-wave Doppler recordings. Left ventricular mass index (LVMI) was determined according to the Devereux formula. hs-cTnT, uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were measured in all patients.
  
  
  RESULTS
  Hs-cTnT, hs-CRP, and uric acid levels were higher in the MPIhigh group compared with the MPIlow group (p < 0.05, for all). The LVMI values in the MPIhigh group were higher than in the MPIlow group (p < 0.05). MPI was independently associated with age, uric acid, hs-cTnT, and LVMI in multivariate analysis. Multivariate logistic regression analysis showed that MPI and LVMI were independent predictors of high hs-cTnT level in newly diagnosed hypertensive patients with preserved LVEF.
  
  
  CONCLUSIONS
  Hs-cTnT was independently associated with LV dysfunction and LV hypertrophy assessed with MPI in newly diagnosed hypertensive patients.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey. onurkaypakli@hotmail.com.
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypakli
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.affiliation: Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey.
authors.forename: Mehmet Yavuz
authors.initials: MY
authors.lastname: Gözükara
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kivrak
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Durmuş Yildiray
authors.initials: DY
authors.lastname: Şahin
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital, 01170, Adana, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Çayli
mesh_terms: D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D015150:Echocardiography, Doppler / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D020107:Troponin T / Q000097:blood*; D014421:Turkey / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology*
chemical_list: D015415:Biomarkers; D020107:Troponin T
keywords: High-sensitivity troponin; Hypertension; Left ventricular mass; Myocardial performance; Uric acid