title: Regulation and function of the human HSP90AA1 gene.
abstract: Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins. These differences are likely due to variations in nucleotide sequence within non-coding regions, which allows for specific regulation through interaction with particular transcription factors, and to subtle changes in amino acid sequence that allow for unique post-translational modifications. This article will specifically focus on the expression, function and regulation of Hsp90α.
authors.affiliation: Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: abbey.zuehlke@nih.gov.
authors.forename: Abbey D
authors.initials: AD
authors.lastname: Zuehlke
authors.affiliation: Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Beebe
authors.affiliation: Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Len
authors.initials: L
authors.lastname: Neckers
authors.affiliation: Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prince
mesh_terms: D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic; D060066:Protein Interaction Maps; D011499:Protein Processing, Post-Translational
chemical_list: D018841:HSP90 Heat-Shock Proteins; C112969:HSP90AA1 protein, human
keywords: Cancer; Drug target; Gene ontology; Gene promoter; Heat shock element; Heat shock protein; Interactome; Molecular chaperone; Post-translational modification; Stress response