title: Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses.
abstract: OBJECTIVE
  This study aimed to evaluate the increase in tear meniscus height (TMH) induced by 3% diquafosol ophthalmic solution in eyes with contact lens (CL).
  
  
  METHODS
  Ten healthy subjects wearing high-water-content CLs received topical instillation of two ophthalmic solutions - 3% diquafosol ophthalmic solution in one eye and artificial tears in the other eye. Lower TMH was measured at 5 minutes, 10 minutes, 15 minutes, 30 minutes, and 60 minutes after instillation by anterior segment optical coherence tomography.
  
  
  RESULTS
  TMH increased significantly (P<0.001) at 5 minutes and 15 minutes after instillation of saline compared with the baseline values. After instillation of 3% diquafosol ophthalmic solution, TMH significantly increased (P<0.05) at 5 minutes, 15 minutes, 30 minutes, and 60 minutes compared with the baseline values. Increases in TMH after diquafosol instillation were significantly greater (P<0.05) at 15 minutes, 30 minutes, and 60 minutes than increases in TMH after saline instillation.
  
  
  CONCLUSIONS
  Topical instillation of 3% diquafosol ophthalmic solution increases TMH for up to 60 minutes in eyes with high-water-content CLs.
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nagahara
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Koh
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan ; Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Watanabe
keywords: contact lenses; diquafosol ophthalmic solution; dry eye; tear film; tear meniscus height