title: Identification of a new clade of hepatitis B virus genotype F.
abstract: Hepatitis B virus (HBV) is classified into eight main genotypes (A-H) and several subgenotypes. Here, three new genotype F complete genome sequences isolated from patients from Buenos Aires city are reported. The new sequences form a separate monophyletic group from the previously known subgenotype F4 strains. Based on results of phylogenetic, genetic distance and evolutionary analyses, the name F4b is proposed for these isolates and F4a for the formerly known as F4. The identification of new clusters allows deepening the knowledge about the diversification process and evolutionary history of HBV.
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4to piso, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: lmojsiejczuk@ffyb.uba.ar.
authors.forename: Laura Noelia
authors.initials: LN
authors.lastname: Mojsiejczuk
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4to piso, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Carolina
authors.initials: C
authors.lastname: Torres
authors.affiliation: Unidad de Hepatopatías Infecciosas, Hospital F.J. Muñiz, Uspallata 2272, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Hugo Alberto
authors.initials: HA
authors.lastname: Fainboin
authors.affiliation: Sección Hepatología, Hospital Italiano, Juan D. Perón 4190, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Omar Andres
authors.initials: OA
authors.lastname: Galdame
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4to piso, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Rodolfo Hector
authors.initials: RH
authors.lastname: Campos
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 4to piso, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Diego Martin
authors.initials: DM
authors.lastname: Flichman
mesh_terms: D016000:Cluster Analysis; D016384:Consensus Sequence; D014644:Genetic Variation; D005838:Genotype; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D017422:Sequence Analysis, DNA
keywords: Diversity; Evolution; HBV genotype F; Hepatitis B virus; Phylogenetics