title: The relationship between the expression of VEGF, EGFR, and HER-2 mRNA in esophageal squamous cell carcinoma (ESCC) and clinicopathological features of different ethnic groups in Xinjiang.
abstract: The purpose of this study was to explore the relationship between the expression of vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER-2), and epidermal growth factor receptor (EGFR) mRNA in esophageal squamous cell carcinoma (ESCC) and the clinicopathological characteristics of the Han, Uyghur, and Kazakh in Xinjiang. Real-time quantitative polymerase chain reaction technology (RT-PCR) was used to detect the expression of VEGF, HER-2, and EGFR mRNA in esophageal squamous cancer tissue of 60 cases and 30 cases of VEGF, HER-2, and EGFR mRNA in esophageal cancer adjacent tissues, and analyze its relationship with clinicopathological features. The results were as follows: (1) There was no statistically significant difference in esophageal tissue VEGF, HER-2, and EGFR mRNA gene expression levels of the Han, Uyghur, and Kazakh patients (P > 0.05). (2) The expression levels of VEGF, HER-2, and EGFR mRNA in ESCC group were higher than those in adjacent esophageal tissue group (P < 0.05). (3) The expression levels of VEGF and HER-2 mRNA in ESCC of the Han patients were higher than those of the Uyghur and Kazakh patients (P < 0.05). (4) The expression levels of VEGF, HER-2, and EGFR mRNA in lymph node metastases were higher than those without lymph node metastasis (P < 0.05). (5) The expression level of HER-2 mRNA was related with the degrees of pathological differentiation, and the higher pathologic degree, the lower expression level in HER-2 mRNA (P < 0.05). Therefore, the following conclusions were drawn: (1) There were ethnic differences in the VEGF and HER-2 gene mRNA expression levels of the Uyghur, Han, and Kazakh patients in Xinjiang. (2) The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree.
authors.affiliation: Medicine VIP, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China. zhangli9514@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Medicine VIP, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Cancer Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Bai
authors.affiliation: Cancer Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Cancer Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.affiliation: Medicine VIP, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005006:Ethnicity / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000096:biosynthesis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D042461:Vascular Endothelial Growth Factor A; C467484:VEGFA protein, human; C512478:EGFR protein, human; C508053:ERBB2 protein, human
keywords: Clinicopathological features; ESCC; Gene; RT-PCR