title: Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition.
abstract: An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is described. High yields and simple operations are important features of this methodology.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. wcchen@taigenbiotech.com.
authors.forename: Wen-Chang
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. kavalaveeru@gmail.com.
authors.forename: Veerababurao
authors.initials: V
authors.lastname: Kavala
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. coshih@gmail.com.
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Shih
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. baby11710@hotmail.com.
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Wang
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. cwkuo.water@gmail.com.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Kuo
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. a129084303xx@gmail.com.
authors.forename: Tang-Hao
authors.initials: TH
authors.lastname: Yang
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. tlotras@gmail.com.
authors.forename: Chia-Yu
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. a210627@hotmail.com.
authors.forename: Hao-Hsiang
authors.initials: HH
authors.lastname: Chiu
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Ting-Chow Road, Taipei 116, Taiwan. cheyaocf@ntnu.edu.tw.
authors.forename: Ching-Fa
authors.initials: CF
authors.lastname: Yao
mesh_terms: D061565:Cycloaddition Reaction; D007555:Isoxazoles / Q000138:chemical synthesis*; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D007555:Isoxazoles; D009569:Nitric Oxide
keywords: Yamaguchi reagent; bicyclic isoxazole/isoxazolines; cycloaddition; nitrile oxide; nitroalkane