title: An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect.
abstract: A new C-methylisoflavone, isosideroxylin (1), and a known C-methylflavone, sideroxylin (2), were isolated from the EtOAc extract of the leaves of Leiophyllum buxifolium. The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER(-) MDA-MB-231 and ER(+) MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (1) displayed a selective antiproliferative effect against MDA-MB-231 cells.
authors.affiliation: †Program in Pharmacognosy, Department of Chemistry and Biochemistry, and ‡Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
authors.forename: Dan
authors.initials: D
authors.lastname: Tian
authors.affiliation: †Program in Pharmacognosy, Department of Chemistry and Biochemistry, and ‡Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
authors.forename: John R
authors.initials: JR
authors.lastname: Porter
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D029791:Ericaceae / Q000737:chemistry*; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D061986:MCF-7 Cells; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009515:New Jersey; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007529:Isoflavones; C561549:sideroxylin