title: Drug-induced glomerular disease: immune-mediated injury.
abstract: Drug-induced autoimmune disease was initially described decades ago, with reports of vasculitis and a lupus-like syndrome in patients taking hydralazine, procainamide, and sulfadiazine. Over the years, multiple other agents have been linked to immune-mediated glomerular disease, often with associated autoantibody formation. Certain clinical and laboratory features may distinguish these entities from their idiopathic counterparts, and making this distinction is important in the diagnosis and management of these patients. Here, drug-induced, ANCA-associated vasculitis, drug-induced lupus, and drug-associated membranous nephropathy are reviewed.
authors.affiliation: Department of Medicine, Division of Nephrology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and jonathan.hogan2@uphs.upenn.edu.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Hogan
authors.affiliation: Department of Pathology and.
authors.forename: Glen S
authors.initials: GS
authors.lastname: Markowitz
authors.affiliation: Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York.
authors.forename: Jai
authors.initials: J
authors.lastname: Radhakrishnan
mesh_terms: D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000187:drug effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008181:Lupus Nephritis / Q000139:chemically induced / Q000276:immunology; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D001323:Autoantibodies
keywords: ANCA; GN; SLE; drug nephrotoxicity; membranous nephropathy