title: [Significance of efflux pumps in multidrug resistance of Gram-negative bacteria].
abstract: The phenomenon of multidrug. resistance of bacteria is a serious problem of modern medicine. This resistance largely is a consequence of abuse and improper use of antibacterial substances, especially antibiotics and chemotherapeutics in hospital settings. Multidrug resistance is caused by a number of interacting mechanisms of resistance. Recent studies have indicated that efflux pumps and systems of efflux pumps are an important determinant of this phenomenon. Contribute to this particular RND efflux systems of Gram-negative bacteria, which possess a wide range of substrates such as antibiotics, dyes, detergents, toxins and active substances of disinfectants and antiseptics. These transporters are usually encoded on bacterial chromosomes. Genes encoding efflux pumps' proteins may also be carried on plasmids and other mobile genetic elements. Such pumps are usually specific to a small group of substrates, but as an additional mechanism of resistance may contribute to the multidrug resistance.
authors.forename: Olga
authors.initials: O
authors.lastname: Wiercińska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Chojecka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Kanclerski
authors.forename: Ewa
authors.initials: E
authors.lastname: Rőhm-Rodowald
authors.forename: Bożenna
authors.initials: B
authors.lastname: Jakimiak
mesh_terms: D018432:Drug Resistance, Multiple / Q000502:physiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism*
chemical_list: D026901:Membrane Transport Proteins