title: Should white blood cell scan be replaced by (18)F-FDG PET-CT in the diagnosis of prosthetic vascular graft infection?
abstract: Diagnosis of prosthetic vascular graft infection (PVGI) is a clinical challenge requiring accurate diagnostic methods for their optimal management. A 65-year-old patient with suspected PVGI was explored by fluorodeoxyglucose positron emission tomography combined with computed tomography ((18)F-FDG PET-CT) for pretreatment staging. Standard imaging was unrevealing but PET images showed multiple foci with increased uptake suggesting prosthetic infection. While routine results from the diagnostic laboratory were negative, prosthesis sonication before standard culture revealed the same bacterium as a culture of preoperative lymphocele aspiration. (18)F-FDG PET-CT and preliminary sonication of the prosthetic graft could be very helpful in the diagnosis of PVGI especially for highlighting biofilm bacteria.
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Bordeaux, France. Electronic address: Jean-baptiste.pinaquy@chu-bordeaux.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Pinaquy
authors.affiliation: CHU de Bordeaux, Service de Chirurgie Vasculaire, Bordeaux, France; CHU de Bordeaux, CIC-IT BioDiMI, Bordeaux, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Berard
authors.affiliation: CHU de Bordeaux, Département d'Anesthésie, Bordeaux, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Stecken
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Bordeaux, France.
authors.forename: Ghoufrane
authors.initials: G
authors.lastname: Tlili
authors.affiliation: Université de Bordeaux, Aquitaine Microbiologie, UMR 5234, Bordeaux, France; CNRS, Aquitaine Microbiologie, UMR 5234, Bordeaux, France.
authors.forename: Fatima
authors.initials: F
authors.lastname: M'zali
authors.affiliation: CHU de Bordeaux, Service de Médecine Nucléaire, Bordeaux, France; CHU de Bordeaux, CIC-IT BioDiMI, Bordeaux, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Bordenave
authors.affiliation: Université de Bordeaux, USC EA 3671, Infections Humaines à Mycoplasmes et à Chlamydiae, Bordeaux, France; INRA, USC EA3671, Infections Humaines à Mycoplasmes et à Chlamydiae, Bordeaux, France; CHU de Bordeaux, Laboratoire de Bactériologie, Bordeaux, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Pereyre
authors.affiliation: CHU de Bordeaux, Service de Chirurgie Vasculaire, Bordeaux, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mayeux
authors.affiliation: Université de Bordeaux, USC EA 3671, Infections Humaines à Mycoplasmes et à Chlamydiae, Bordeaux, France; INRA, USC EA3671, Infections Humaines à Mycoplasmes et à Chlamydiae, Bordeaux, France; CHU de Bordeaux, Service des Maladies Infectieuses et Tropicales, Bordeaux, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Cazanave
mesh_terms: D000368:Aged; D001419:Bacteria / Q000254:growth & development / Q000302:isolation & purification; D018441:Biofilms; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000295:instrumentation; D020878:Device Removal; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000601:surgery; D019275:Radiopharmaceuticals; D012086:Reoperation; D012501:Saphenous Vein / Q000637:transplantation; D013010:Sonication; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18