title: Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.
abstract: An efficient preparation of the antimalarial drug candidate OZ439, which was obtained by integrating a machine-assisted approach with batch processes, is reported. This approach allows a rapid and cost-effective production of the key intermediates that were readily elaborated into the target molecule.
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Shing-Hing
authors.initials: SH
authors.lastname: Lau
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Alicia
authors.initials: A
authors.lastname: Galván
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Merchant
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.|‡Departamento de Química Orgánica, Universidade de Vigo, Vigo, 36310, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Souto
authors.affiliation: §GlaxoSmithKline, Stevenage SG1 2NY, U.K.
authors.forename: Malcolm B
authors.initials: MB
authors.lastname: Berry
authors.affiliation: †Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008288:Malaria / Q000188:drug therapy*; D015394:Molecular Structure; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D010545:Peroxides; D000218:Adamantane; C558165:artefenomel