title: Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians.
abstract: The cardio-ankle vascular index is a measure of arterial stiffness, whereas oxidative stress underlies arterial pathology. This study aimed to investigate the association between the cardio-ankle vascular index and antioxidant-related gene polymorphisms in young Russians. A total of 89 patients (mean age, 21.6 years) were examined by the cardio-ankle vascular index and for 15 gene polymorphisms related to antioxidant enzymes including FMO3 (flavin-containing monooxygenase 3), GPX1 (glutathione peroxidase 1), and GPX4 (glutathione peroxidase 4). A higher cardio-ankle vascular index level was detected in carriers with the KK-genotype of FMO3 polymorphism rs2266782 than in those without (mean levels: 6.2 versus 5.6, respectively, p<0.05). Similarly, a higher cardio-ankle vascular index level was seen in carriers with the CC-genotype of GPX4 polymorphism rs713041 than in those without (6.0 versus 5.5, respectively, p<0.05). We did not observe significant associations between the cardio-ankle vascular index levels and the other gene polymorphisms. Although carriers with the LL-genotype of GPX1 polymorphism rs1050450 showed a higher diastolic blood pressure level than those without, the polymorphism did not affect the cardio-ankle vascular index level. This study showed a significant association between rs2266782 and rs713041 polymorphisms and arterial stiffness, as measured by the cardio-ankle vascular index, in young Russians. The pathways utilised by antioxidant enzymes may be responsible for early arterial stiffening in the Russian population.
authors.affiliation: 1Department of Internal Medicine,Kursk State Medical University,Kursk,Russia.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Sorokin
authors.affiliation: 2Department of Clinical Laboratory Medicine,Jichi Medical University,Tochigi,Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kotani
authors.affiliation: 3Department of Biology, Medical Genetics and Ecology,Kursk State Medical University,Kursk,Russia.
authors.forename: Olga Y
authors.initials: OY
authors.lastname: Bushueva
authors.affiliation: 3Department of Biology, Medical Genetics and Ecology,Kursk State Medical University,Kursk,Russia.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Polonikov
mesh_terms: D055109:Ankle Brachial Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic; D012426:Russia; D055815:Young Adult
keywords: Ankle-brachial index; antioxidant enzymes; arterial stiffness; cardio-ankle vascular index; gene polymorphisms