title: The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF- κ B Pathway in Mice.
abstract: A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-α on day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.
authors.affiliation: Department of Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Chen
authors.affiliation: Institute of Chinese Medicine, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Qianlin
authors.initials: Q
authors.lastname: Yan
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Jiajun
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Xunlong
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Chinese Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China.
authors.forename: Tianxiong
authors.initials: T
authors.lastname: Han
authors.affiliation: Department of Biosynthesis, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhu