title: [Anti-tumor metastatic constituents from Rhodiola wallichiana].
abstract: To study the anti-tumor metastatic constituents in Rhodiola wallichiana (HK) S H Fu var Cholaensis (Praeg) S H Fu, chemical constituents were isolated and purified by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The anti-tumor metastasis assay was applied to evaluate the activities of the isolated compounds. Ten compounds (1-10) were isolated and their structures were identified by comparison of their spectral data with literature as follows: syringic acid (1), salidroside (2), tyrosol (3), scaphopetalone (4), berchemol (5), 2,6-dimethoxyacetophenone (6), rhobupcyanoside A (7), miyaginin (8), chavicol-4-O-β-D-apiofuranosyl-(1 --> 6)-O-β-D-glucopyranoside (9), eugenyol-O-β-D-apiofuranosyl-(1 --> 6)-O-β-D-glucopyranoside (10). Compounds 4-6 and 8-10, were isolated from this genus for the first time, while compound 7 was isolated from this plant for the first time. Compounds 2, 6-8 showed positive anti-tumor metastatic activities, and compounds 2 and 8 showed significant anti-tumor metastatic activities.
authors.forename: Ya-qing
authors.initials: YQ
authors.lastname: Chai
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Zhao
authors.forename: Ren-jiu
authors.initials: RJ
authors.lastname: Wang
authors.forename: Ming-guang
authors.initials: MG
authors.lastname: Cao
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Wu
authors.forename: Sheng-an
authors.initials: SA
authors.lastname: Tang
authors.forename: Hong-quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D029771:Rhodiola / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic