title: Histopathology of Measles: Report of 2 Cases With New Findings.
abstract: The authors report 2 cases of measles demonstrating novel skin pathology that may be useful in establishing early diagnosis. Syncytial epithelial giant cells, which are characteristic of measles, were found to be present in the dermis, indicating that these cells are not specific to the lymphoid tissue and epithelia of which they are classically attributed to. The cells were not prominent, and required step sectioning to observe. These results were confirmed by electron microscopy, which showed virus capsid particles within the endoplasmic reticulum, secretory vesicles, and cytoplasm of multinucleated cells. One of the cases also demonstrated an unusual mixed infiltrate of eosinophils and fibrin thrombi, which has not been previously described. Both patients in this report recovered with supportive therapy.
authors.affiliation: Departments of Dermatology and Pathology, Icahn School of Medicine, New York, NY.
authors.forename: Harleen K
authors.initials: HK
authors.lastname: Sidhu
authors.forename: Julien
authors.initials: J
authors.lastname: Lanoue
authors.forename: Rachel
authors.initials: R
authors.lastname: Nazarian
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Mercer
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Gordon
authors.forename: Robert G
authors.initials: RG
authors.lastname: Phelps
mesh_terms: D002213:Capsid / Q000648:ultrastructure; D020405:Dermis / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D015726:Giant Cells / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008457:Measles / Q000473:pathology*; D008459:Measles virus; D008875:Middle Aged; D017193:Skin Diseases, Viral / Q000473:pathology*; D055815:Young Adult