title: Trends in the enantiomeric composition of polychlorinated biphenyl atropisomers in human breast milk.
abstract: For the precise estimation of the risk to human health caused by persistent organic pollutants (POPs), it is important to discuss enantiomer fraction value (EF value) because it is reported that behaviors such as stability and toxicity of enantiomers are quite different in human body. Among POPs, polychlorinated biphenyl (PCB) is known as one of the most persistent compounds in human breast milk samples. The main exposure source of PCB for human body is mostly from food especially in seafood. The contamination of fish and shellfish has been a serious problem for the Japanese, who consume a large amount of fish in their diet. PCBs have 19 congeners which are chlorine-substituted in 3- or 4- ortho positions are known to have enantiomers. In this study, we analyzed PCB 183 (2,2',3,4,4',5',6-hepta CB) in human breast milk and fish samples enantioselectively and revealed the time trends of the EF value. Though EF value of PCB 183 in fish samples sustained close to racemate (EF = 0.5) from 1982 to 2012, that in breast milk increased over time. This fact indicates that (+)-PCB-183 has greater bioaccumulation potential than (-)-PCB-183 in human body; therefore, the toxicity of (+)-PCB-183 should be emphasized.
authors.affiliation: Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 537-0025, Osaka, Japan. konisi@iph.pref.osaka.jp.
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Konishi
authors.affiliation: Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 537-0025, Osaka, Japan.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Kakimoto
authors.affiliation: Osaka Prefectural Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, 537-0025, Osaka, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Nagayoshi
authors.affiliation: Research Center for Environmental Preservation, Osaka University, 2-4, Yamadaoka, Suita, Osaka, 565-0871, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D005399:Fishes; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D011078:Polychlorinated Biphenyls / Q000737:chemistry* / Q000378:metabolism*; D017747:Seafood; D013237:Stereoisomerism; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000378:metabolism
chemical_list: D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls
keywords: 2,2′,3,4,4′,5′,6-hepta CB; Enantiomer fraction value; Enantiomer selective analysis; High resolution gas chromatography/high resolution mass chromatography; Human breast milk; Market basket study