title: A case of tardive dyskinesia in the last weeks of life.
abstract: Tardive dyskinesia (TD) is a chronic and often irreversible movement disorder that usually evolves after years of neuroleptic use but can sometimes develop over a much shorter time frame. Paradoxically, a higher dose of the neuroleptic agent that causes TD can often temporarily suppress the movement disorder. This is generally an inadvisable approach, though, as its effectiveness is probably limited to only a matter of weeks and as it will worsen the problem in the long run. We describe a patient with widely metastatic squamous cell carcinoma of the lung who developed severe TD when treated with chlorpromazine for severe hiccups. As his prognosis was only days to weeks, we were able to effectively suppress his TD with haloperidol. Hospice care emphasizes relief of suffering at the end of life, often at the expense of attention to long-range adverse effects, and this approach may be a viable management strategy for patients with TD and very limited prognosis.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Yehl
authors.forename: Inna
authors.initials: I
authors.lastname: Sheyner
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Fasnacht
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Stewart
mesh_terms: D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D002746:Chlorpromazine / Q000009:adverse effects / Q000627:therapeutic use; D006220:Haloperidol / Q000627:therapeutic use; D006606:Hiccup / Q000188:drug therapy; D017051:Hospice Care / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy / Q000209:etiology*
chemical_list: D018726:Anti-Dyskinesia Agents; D006220:Haloperidol; D002746:Chlorpromazine
keywords: chlorpromazine; dopamine; extrapyramidal symptoms; free radicals; haloperidol; lung cancer; neuroleptics; tardive dyskinesia