title: Deregulation of protein translation control, a potential game-changing hypothesis for Parkinson's disease pathogenesis.
abstract: Protein translation is one of the most fundamental and exquisitely controlled processes in biology, and is energetically demanding. The deregulation of this process is deleterious to cells, as demonstrated by several diseases caused by mutations in protein translation machinery. Emerging evidence now points to a role for protein translation in the pathogenesis of Parkinson's disease (PD); a debilitating neurodegenerative movement disorder. In this paper, we propose a hypothesis that protein translation machinery, PD-associated proteins and PD pathology are connected in a functional network linking cell survival to protein translation control. This hypothesis is a potential game changer in the field of the molecular pathogenesis of PD, with implications for the development of PD diagnostics and disease-modifying therapies.
authors.affiliation: UMR-S1172 Jean-Pierre Aubert Research Center - (INSERM - CHRU de Lille - Université de Lille), Early Stages of Parkinson's Disease Team, Lille, France. Electronic address: jean-marc.taymans@inserm.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Taymans
authors.affiliation: UMR-S1172 Jean-Pierre Aubert Research Center - (INSERM - CHRU de Lille - Université de Lille), Early Stages of Parkinson's Disease Team, Lille, France.
authors.forename: Aurore
authors.initials: A
authors.lastname: Nkiliza
authors.affiliation: UMR-S1172 Jean-Pierre Aubert Research Center - (INSERM - CHRU de Lille - Université de Lille), Early Stages of Parkinson's Disease Team, Lille, France. Electronic address: marie-christine.chartier-harlin@inserm.fr.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Chartier-Harlin
mesh_terms: D005786:Gene Expression Regulation; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis
keywords: EIF4G1; LRRK2; alpha-synuclein; ribosome; translation elongation factor; translation initiation factor