title: New Polyphenols Identified in Artemisiae abrotani herba Extract.
abstract: Artemisia abrotanum L. ("southernwood") belongs to the Artemisia genus and it is used in traditional medicine for the treatment of a variety of illnesses. Scarce data is available on the chemical composition of this medicinal plant, most research being focused on the quantitative and qualitative analyses of its essential oil. Our aim was to investigate the content and profile of polyphenols, flavonoids and hydroxycinnamic derivatives present in the Artemisiae abrotani herba extract. We conducted LC/MS analysis and we screened for 19 polyphenols, flavonoids and hydroxycinnamic derivatives. We determined the total content of these compounds and we screened for antioxidant activity. Most polyphenol acids, hydroxycinnamic derivatives and flavonoids were identified and quantified for the first time in this study. We found an original polyphenol distribution profile with high concentration of sinapic acid, rutin, quercetol, ferulic acid and patuletin. We measured the antioxidant activity, the ethanolic extract presenting a modest radical scavenging activity. The value of this study consists in its novelty as it adds new data on the chemical composition of A. abrotanum L. and it opens novel perspectives for medical and nutritional applications of this plant.
authors.affiliation: Pharmaceutical Botany Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Marinescu Street, Cluj-Napoca 400037, Romania. comsa.elisabeta@umfcluj.ro.
authors.forename: Elisabeta
authors.initials: E
authors.lastname: Baiceanu
authors.affiliation: Pharmaceutical Technology and Biopharmaceutics Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 12 I. Creanga Street, Cluj-Napoca 400010, Romania. laurian.vlase@umfcluj.ro.
authors.forename: Laurian
authors.initials: L
authors.lastname: Vlase
authors.affiliation: Physical Chemistry Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur Street, Cluj-Napoca 400349, Romania. baiceanu.andrei@umfcluj.ro.
authors.forename: Andrei
authors.initials: A
authors.lastname: Baiceanu
authors.affiliation: Physical Chemistry Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur Street, Cluj-Napoca 400349, Romania. madalinananes@yahoo.com.
authors.forename: Madalina
authors.initials: M
authors.lastname: Nanes
authors.affiliation: Physical Chemistry Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 6 Louis Pasteur Street, Cluj-Napoca 400349, Romania. drusu@umfcluj.ro.
authors.forename: Dan
authors.initials: D
authors.lastname: Rusu
authors.affiliation: Pharmaceutical Botany Department, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Marinescu Street, Cluj-Napoca 400037, Romania. gcrisan@umfcluj.ro.
authors.forename: Gianina
authors.initials: G
authors.lastname: Crisan
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002853:Chromatography, Liquid; D005419:Flavonoids / Q000737:chemistry; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010936:Plant Extracts; D059808:Polyphenols
keywords: Artemisia abrotanum L.; bioactive compounds; flavonoids; healthy nutrition; hydroxycinnamic derivatives; natural antioxidants; phenolic acids; polyphenols