title: Reshaping the protein folding pathway by osmolyte via its effects on the folding intermediates.
abstract: It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway and the energy landscape. The present article describes the advances made so far in understanding the effects of organic osmolytes on the folding intermediates and pathways. The ability of osmolytes to rescue disease causing mutations in proteins by inducing proper folding into functionally active form is also discussed. Finally, some future directions are described.
authors.forename: Gurumayum Suraj
authors.initials: GS
authors.lastname: Sharma
authors.forename: Tanveer Ali
authors.initials: TA
authors.lastname: Dar
authors.affiliation: Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India. lrsingh@acbr.du.ac.in.
authors.forename: Laishram Rajendrakumar
authors.initials: LR
authors.lastname: Singh
mesh_terms: D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D009994:Osmolar Concentration; D011487:Protein Conformation / Q000187:drug effects; D017510:Protein Folding / Q000187:drug effects*; D055550:Protein Stability; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D064267:Intrinsically Disordered Proteins; D011506:Proteins