title: Discrepancy in impact of maternal milk on vertical transmission between Hepatitis B virus and Human cytomegalovirus.
abstract: OBJECTIVE
  This study aims to elucidate the role of breastfeeding on vertical transmission of HCMV and HBV and to investigate the difference in perinatal transmission via breast milk between HBV and HCMV.
  
  
  METHODS
  This detailed study monitored the kinetics of viral DNA load in maternal milk for both HBV and HCMV, demonstrated the rate of transmission to infants, and compared HBV infection rate with that of HCMV.
  
  
  RESULTS
  There was no difference in overall DNAlactia+ between HBV (23.86%) and HCMV (29.54%, P=0.140) for seropositive mothers, while HBsAg prevalence (0.75%) was significantly lower than HCMV IgG+ (27.44%, P<0.001) for the breast-fed babies. Between breast-fed babies of seropositive mothers and those of seronegative mothers, HBV infection rate had no difference (HBsAg+: 0.75% vs 0%, P=0.538; DNAemia+: 0.38% vs 0%, P=0.664), but HCMV infection rate of the former was significantly higher than that of the latter (IgG+: 27.07% vs 18.00%, P=0.045; DNAemia+: 15.79% vs 4.00%, P=0.027).
  
  
  CONCLUSIONS
  Breastfeeding is not a risk factor for maternal-to-infant transmission of HBV after the recommended prophylaxis is implemented. However, viral DNA positive breast milk is a main source for vertical transmission of HCMV to infants who are not protected by a standard immunoprophylaxis protocol.
authors.affiliation: Medical Laboratory, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: Medical Laboratory, Children's Hospital of Zhengzhou, 255 Gangdu Street, Zhengzho 450053, China.
authors.forename: Meiye
authors.initials: M
authors.lastname: Wang
authors.affiliation: Medical Laboratory, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, China.
authors.forename: Gehong
authors.initials: G
authors.lastname: Duan
authors.affiliation: Medical Laboratory, Henan Provincial People's Hospital, 7 Weiwu Road, Zhengzhou 450003, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Medical Laboratory, the Second Affiliated Hospital of Zhengzhou University, 2 Jingba Road, Zhengzhou 450014, China. Electronic address: yanxiahe1961@126.com.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001942:Breast Feeding / Q000009:adverse effects*; D003587:Cytomegalovirus / Q000276:immunology* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000635:transmission*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007114:Immunization; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008892:Milk / Q000821:virology*; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors; D019562:Viral Load; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens
keywords: Hepatitis B virus; Human cytomegalovirus; Maternal milk; Vaccine; Vertical transmission