title: Comparison of ketorolac 0.45% versus diclofenac 0.1% for macular thickness and volume after uncomplicated cataract surgery.
abstract: OBJECTIVE
  To compare the effects of ketorolac 0.45% and diclofenac 0.1% on macular thickness and volume after uncomplicated cataract surgery.
  
  
  METHODS
  A total of 76 eyes of 76 patients who underwent uncomplicated cataract surgery were included. Patients were treated with either diclofenac 0.1% (38 eyes) or ketorolac 0.45% (38 eyes) after surgery. The macular thickness and volume were obtained with optical coherence tomography (OCT). Central subfield thickness (CST, OCT 1 mm zone), total foveal thickness (TFT, OCT 3 mm zone), total macular thickness (TMT, OCT 6 mm zone), average macular thickness (AMT) and total macular volume (TMV) were compared between the two study groups.
  
  
  RESULTS
  No significant differences between groups were found in macular thickness or volume 1 month after cataract surgery. Two months after surgery, the ketorolac group had significantly lower CST, TFT, TMT and AMT than the diclofenac group (p < 0.05 for all). Additionally, 1 and 2 months after surgery, changes from preoperative values in CST (both p = 0.04), AMT (p = 0.02 and p < 0.01, respectively) and TMV (both p = 0.04) were significantly less in the ketorolac group than in the diclofenac group.
  
  
  CONCLUSIONS
  Following uncomplicated cataract surgery, topical ketorolac 0.45% was more effective than diclofenac 0.1% in preventing increases in macular thickness and volume.
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
authors.forename: Yong Sok
authors.initials: YS
authors.lastname: Ji
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, South Korea.
authors.forename: Kyung Chul
authors.initials: KC
authors.lastname: Yoon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D020910:Ketorolac / Q000627:therapeutic use*; D019654:Lens Implantation, Intraocular; D008266:Macula Lutea / Q000187:drug effects* / Q000473:pathology; D008269:Macular Edema / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000517:prevention & control*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac; D020910:Ketorolac
keywords: average macular thickness; central subfield thickness; diclofenac sodium 0.1%; ketorolac tromethamine 0.45%; total foveal thickness; total macular thickness; total macular volume