title: Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease.
abstract: Argyrophilic grain (ArG) is the main pathological feature of argyrophilic grain disease (AGD) and is clinically characterized by cognitive impairment, behavioral abnormalities, personality changes, and emotional imbalances. However, ArG can not only be found in AGD but also in various other neurological disorders, including Parkinson's disease (PD). The association of ArG with psychosis and/or dementia in various neurological disorders remains unknown; in this study, we have investigated this in PD. The distribution and degree of ArG deposition, spongiform change in the transentorhinal cortex (TER SpC), and phosphorylated alpha-synuclein-positive neurites in CA2/3 were assessed, and we used formalin-fixed, paraffin-embedded specimens obtained from the anterior/posterior medial temporal region of 20 autopsy cases diagnosed as PD. These cases were clinically divided into two groups: PD without dementia (PDND) and PD with dementia (PDD). Most PDD cases revealed scattered to numerous ArG or moderate to severe TER SpC, both of which were rarely observed in the PDND group. Furthermore, by the degree of ArG density and TER SpC, the PDD group was further divided into three subtypes: PDD with ArG, with TER SpC and without ArG/TER SpC. Scattered-to-numerous ArG and/or moderate-to-severe TER SpC were observed only in PDD, which suggested that both ArG and TER SpC could be important factors affecting dementia in PD and that their distribution and degree are equally important.
authors.affiliation: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.|Department of Pathology, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Homma
authors.affiliation: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.|Department of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Centre for the Disabled, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Mochizuki
authors.affiliation: Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.|Department of Neurology, Saitama Medical University, Saitama, Japan.
authors.forename: Kazushi
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Komori
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D003704:Dementia / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010766:Phosphorylation; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D051844:alpha-Synuclein
keywords: Parkinson's disease; argyrophilic grain; cerebral limbic system; dementia; spongiform change