title: The spontaneous regression of palmoplantar pustulosis following removal of dental amalgams: A report of two cases.
abstract: Metal allergens are occasionally reported to be associated with palmoplantar pustulosis. We describe two severe, therapy-resistant, chronic cases of palmoplantar pustulosis induced by metal dental fillings. Both patients' clinical findings and symptoms regressed following the removal of their metal teeth. A patch test examination revealed positive reactions to metal allergens in both cases (in Case 1 the positive reactions were to cobalt chloride hexahydrate and nickel sulfate and in Case 2 the positive reaction was to nickel sulphate). Our studies suggest that metal allergens may play an important role in the pathogenesis of palmoplantar pustulosis.
authors.affiliation: Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine, Nanjing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine, Nanjing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine, Nanjing, China.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine, Nanjing, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Dermatology, Jinling Hospital affiliated to Nanjing University School of Medicine, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Sang
mesh_terms: D000328:Adult; D003723:Dental Amalgam / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011565:Psoriasis / Q000209:etiology* / Q000503:physiopathology; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D014081:Tooth Extraction / Q000379:methods*
chemical_list: D003723:Dental Amalgam
keywords: allergens; cobalt; nickel; palmoplantar pustulosis