title: Responsive foams for nanoparticle delivery.
abstract: We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.
authors.affiliation: Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, United States; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.
authors.forename: Christina
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, United States.
authors.forename: Edward
authors.initials: E
authors.lastname: Xiao
authors.affiliation: Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Sinko
authors.affiliation: Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Szekely
authors.affiliation: Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, United States. Electronic address: prudhomm@princeton.edu.
authors.forename: Robert K
authors.initials: RK
authors.lastname: Prud'homme
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage; D053758:Nanoparticles; D013696:Temperature
chemical_list: D000180:Acrylic Resins; C006903:carbopol 940
keywords: Foams; Nanoparticle; Quick-break; Surfactant