title: Irf6-Related Gene Regulatory Network Involved in Palate and Lip Development.
abstract: Numerous genes including Irf6 have been revealed to contribute to cleft lip with or without cleft palate (CL/P). In this study, we performed a systematic bioinformatics analysis of Irf6-related gene regulatory network involved in palate and lip development by using GeneDecks, DAVID, STRING, and GeneMANIA database. Our results showed that many CL/P candidate genes have relation with Irf6, and 9 of these genes, including Msx1, Pvrl1, Pax9, Jag2, Irf6, Tgfb3, Rara, Gli2, and Tgfb2, were enriched into the CL/P gene group. Some of these 9 genes also were commonly involved in different signaling pathways and different biological processes, and they also have protein-protein interactions with Irf6. These findings make us analyze the intricate function of Irf6 in a CL/P gene regulatory network, followed by guiding us to perform further functional studies on these genes in the future. This method also offers us a simple, cheap, but useful method to analyze the relationship with a gene regulatory network of a certain disease such as CL/P.
authors.affiliation: Department of Oral and Craniomaxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
authors.forename: Jiewen
authors.initials: J
authors.lastname: Dai
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yu
authors.forename: Jiawen
authors.initials: J
authors.lastname: Si
authors.forename: Bing
authors.initials: B
authors.lastname: Fang
authors.forename: Steve Guofang
authors.initials: SG
authors.lastname: Shen
mesh_terms: D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D019295:Computational Biology; D030541:Databases, Genetic; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D054730:Protein Interaction Domains and Motifs / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: C109803:IRF6 protein, human; D050835:Interferon Regulatory Factors