title: MHC class I-related chain B gene polymorphism is associated with virological response to pegylated interferon plus ribavirin therapy in patients with chronic hepatitis C infection.
abstract: The outcome of antiviral therapy is associated with viral and host factors. In the present study, the association between MHC class I-related chain B (MICB) genotypes and therapeutic response to pegylated interferon plus ribavirin (PEG-IFN/RBV) therapy was investigated in hepatitis C virus (HCV)-infected patients. In total, 107 patients with chronic HCV infection (74 with HCV serotype 1 and 33 with serotype 2) were enrolled. Genotyping ofMICBsingle-nucleotide polymorphism (SNP) rs3828913 and interleukin-28B (IL28B) SNP rs8099917 was performed using TaqMan®SNP genotyping assays. The genotype distribution of theMICBalleles was: CC, 79.4%; CA, 17.8%; and AA, 2.8%. Sustained virological response (SVR) was achieved by 55.1% (59/107) of the HCV patients. The SVR rate of patients withMICBmajor (CC) alleles was 62.3% and this rate was significantly higher than that of the patients withMICBminor (CA and AA) alleles (27.2%) (P=0.0068). A multivariate logistic model showed that theMICBmajor genotype was an independent factor contributing to SVR (OR, 4.47; 95% CI, 1.46-13.70; P=0.009). In addition, theMICBgenotype was identified as the sole independent factor contributing to SVR and non-virological response in HCV serotype 1 patients with theIL28Bmajor genotype. In HCV serotype 2 patients, theMICBgenotype was the sole significant factor contributing to SVR (OR, 30.68; 95% CI, 2.72-346.3; P=0.006). In conclusion, theMICBgenotype is a strong predictive factor for virological response to PEG-IFN/RBV therapy in HCV patients.
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Asada
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Shioya
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Osaki
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nishimura
authors.affiliation: Department of Medicine, Notogawa Hospital, Higashioumi 521-1223, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Medicine, Shiga Hospital of Regional Health Care Promotion Organization, Fujimidai, Otsu 520-0846, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Okumura
authors.affiliation: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu 520-2192, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
keywords: MHC class I-related chain B; hepatitis C; interferon; interleukin-28