title: Small intestinal bacterial overgrowth prevalence in celiac disease patients is similar in healthy subjects and lower in irritable bowel syndrome patients.
abstract: BACKGROUND
  Untreated celiac disease has traditionally been linked to a greater risk for small intestinal bacterial overgrowth, but the existing evidence is inconclusive.
  
  
  OBJECTIVE
  To compare the prevalence of small intestinal bacterial overgrowth in subjects with celiac disease compared with control subjects and patients with irritable bowel syndrome.
  
  
  METHODS
  The study included 15 untreated celiac disease patients, 15 subjects with irritable bowel syndrome, and 15 healthy controls. All enrolled patients underwent a lactulose breath test measuring hydrogen and methane. Small intestinal bacterial overgrowth was defined according to previously published criteria.
  
  
  RESULTS
  No differences were found in relation to age or sex. The prevalence of small intestinal bacterial overgrowth was similar between the celiac disease patients and the controls (20 vs. 13.33%, P=NS), whereas it was higher in patients with irritable bowel syndrome (66.66%, P<05).
  
  
  CONCLUSIONS
  There was no difference in the prevalence of small intestinal bacterial overgrowth between the untreated celiac disease patients and healthy controls.
authors.affiliation: Sección de Gastroenterología, Departamento de Medicina Interna, CEMIC, Buenos Aires, Argentina. Electronic address: drjuanslasa@gmail.com.
authors.forename: J S
authors.initials: JS
authors.lastname: Lasa
authors.affiliation: Sección de Gastroenterología, Departamento de Medicina Interna, CEMIC, Buenos Aires, Argentina.
authors.forename: I
authors.initials: I
authors.lastname: Zubiaurre
authors.affiliation: Sección de Gastroenterología, Departamento de Medicina Interna, CEMIC, Buenos Aires, Argentina.
authors.forename: I
authors.initials: I
authors.lastname: Fanjul
authors.affiliation: Sección de Gastroenterología, Departamento de Medicina Interna, CEMIC, Buenos Aires, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Olivera
authors.affiliation: Sección de Gastroenterología, Departamento de Medicina Interna, CEMIC, Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Soifer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D001944:Breath Tests; D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000382:microbiology*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology*; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
keywords: Celiac disease; Enfermedad celíaca; Irritable bowel syndrome; Small intestinal bacterial overgrowth; Sobrecrecimiento bacteriano; Síndrome de intestino irritable