title: Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities.
abstract: Four new phenanthrenoid dimers, effususins A-D (1-4), were isolated from an ethanolic extract of the medullae of Juncus effuses (Juncaceae). Their structures were elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry. Compounds 1-4 was in vitro evaluated for their cytotoxic activities by CCK-8 assay against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG2, Hela, and MCF-7) and their inhibitory effects on NO production in lipopolysaccharide-activated murine macrophage RAW264.7 cells. Effususin B exhibited moderate to strong cytotoxic activities against the tested cancer cell lines and moderate anti-inflammatory activity.
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.
authors.forename: Yun-Yun
authors.initials: YY
authors.lastname: Ding
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China. Electronic address: ln0110@sina.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010616:Phenanthrenes / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry*; D000067996:RAW 264.7 Cells / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D010936:Plant Extracts; D009569:Nitric Oxide
keywords: Anti-inflammatory activity; Cytotoxic activity; Juncaceae; Juncus effusus L.; Phenanthrenoid dimer