title: CORRELATION BETWEEN OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI AND VISUAL OUTCOMES AFTER ANTI-VEGF TREATMENT IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AND POLYPOIDAL CHOROIDAL VASCULOPATHY.
abstract: OBJECTIVE
  To investigate the correlation between hyperreflective foci (HF) on spectral domain optical coherence tomography at baseline and visual outcomes after intravitreal anti-vascular endothelial growth factor injection in neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).
  
  
  METHODS
  The authors retrospectively reviewed the medical records of 44 patients with nAMD and 44 patients with PCV. The number of HF was counted according to the location of HF on spectral domain optical coherence tomography: neurosensory retinal layer, outer retinal layer, and subretinal layer. Statistical correlation between final visual acuity and pretreatment and posttreatment optical coherence tomographic parameters including the number of HF, the status of external limiting membrane and inner segment ellipsoid zone was evaluated.
  
  
  RESULTS
  The number of HF in all retinal layers was reduced in nAMD and PCV after treatment. In multivariate regression analysis, final visual acuity was associated with baseline visual acuity (P = 0.028), number of subretinal HF (P = 0.046), and ellipsoid zone disruption length (P = 0.009) in nAMD. In PCV, final visual acuity was associated with baseline visual acuity (P = 0.001), number of subretinal HF (P = 0.001), and pigment epithelial detachment thickness (P = 0.034). The baseline number of subretinal HF was correlated with final foveal thickness and thickness of subretinal fluid and choroidal neovascularization in nAMD (P = 0.002, P < 0.001, P = 0.009, respectively). In PCV, the baseline number of subretinal HF was correlated with final foveal thickness and ellipsoid zone and external limiting membrane disruption lengths (P = 0.027, P = 0.010, P = 0.020, respectively).
  
  
  CONCLUSIONS
  The number of HF at subretinal layer on spectral domain optical coherence tomography at baseline might predict the final visual acuity after treatment in nAMD and PCV.
authors.affiliation: Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyungwoo
authors.initials: H
authors.lastname: Lee
authors.forename: Bokjun
authors.initials: B
authors.lastname: Ji
authors.forename: Hyewon
authors.initials: H
authors.lastname: Chung
authors.forename: Hyung Chan
authors.initials: HC
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D004396:Coloring Agents / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D058449:Intravitreal Injections; D008297:Male; D011127:Polyps / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012372:ROC Curve; D000069579:Ranibizumab / Q000627:therapeutic use; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D013223:Statistics as Topic; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology*; D057135:Wet Macular Degeneration / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D020533:Angiogenesis Inhibitors; D004396:Coloring Agents; D004338:Drug Combinations; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; D007208:Indocyanine Green; D000069579:Ranibizumab