title: MR Diagnosis of Bone Metastases at 1.5 T and 3 T: Can STIR Imaging Be Omitted?
abstract: OBJECTIVE
  To date, no prospective comparative study of the diagnostic value of STIR versus T1-weighted (T1w) sequences at both 1.5 T and 3 T has been performed with special focus on the detectability of bone metastases.
  
  
  METHODS
  212 oncological patients had a whole-body MRI at 1.5 T and/or at 3 T. The standard protocol comprised STIR and T1w sequences. All patients who showed typical signs of bone metastases were included in the study. Evaluation of the images was performed by the calculation of the number of metastases by three independent readers and by visual assessment on a 4-point scale.
  
  
  RESULTS
  86 patients fulfilled the inclusion criteria. The total number of metastases was significantly higher on T1w than on STIR images at both field strengths (p < 0.05). T1w revealed a sensitivity of 99.72% (3 T) and 100.00% (1.5 T) versus STIR with 70.99 % (3 T) and 79.34 % (1.5 T). In 53% (38/72) of all patients, STIR detected fewer bone metastases in comparison with T1w at 3 T. At 1.5 T, STIR showed inferior results in 37.5 % (18/48) of all patients. Qualitative analysis indicated a significantly better lesion conspicuity, lesion delineation and an improved image quality on T1w compared to STIR imaging at both field strengths (p < 0.05) with similar results for T1w at 1.5 T and 3 T, but inferior results for STIR especially at 3 T.
  
  
  CONCLUSIONS
  The whole-body MRI protocol for the detection of bone metastases could safely be limited to the T1w sequence in adults, especially at 3 T. There is no need for an additional STIR sequence. These initial results will have a major impact on the department's workflow if confirmed by larger studies as they will help reduce examination time and therefore save financial resources.
  
  
  CONCLUSIONS
  In a routine MR protocol, T1w imaging is sufficient for the detection of bone metastases. In case of differential diagnostic problems, other appropriate sequences can be added to the protocol. STIR is inferior to T1w in the detection of metastases, especially at 3 T.
authors.forename: S
authors.initials: S
authors.lastname: Ohlmann-Knafo
authors.forename: A D
authors.initials: AD
authors.lastname: Tarnoki
authors.forename: D L
authors.initials: DL
authors.lastname: Tarnoki
authors.forename: D
authors.initials: D
authors.lastname: Pickuth
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D013131:Spine / Q000473:pathology; D051598:Whole Body Imaging / Q000379:methods*