title: Enhanced circulating ILC2s accompany by upregulated MDSCs in patients with asthma.
abstract: Group 2 innate lymphoid cells (ILC2s) are considered to be the most significant mediators during the orchestration of immune responses in asthma. Myeloid-derived suppressor cells (MDSCs) has received a great deal of attention for their immunosuppressive activity, and our early studies indicate that the increased Th2 cytokines are associated with MDSCs. In this study, we sought to determine whether MDSCs are also participation in immune imbalance and its relationship with ILC2s in asthma. The data showed that the circulatory ILC2s or MDSCs and their characteristic cytokines or transcription factors were significantly enhanced in asthmatic patients, as well as in chronic obstructive pulmonary disease (COPD) or respiratory viral infections (RVI). Meanwhile, a Th2-dominated phenotype was found in patients with asthma which closely related to the expression levels of ILC2s and MDSCs associated moleculars. These findings indicated that Th2 polarization was close related to synergistically increased ILC2s and MDSCs, it may allow to further the comprehension of the contribution of these cells to the inflammatory response involved in asthma or other respiratory tract inflammatory diseases, such as COPD and RVI, as well as to develop novel therapeutic strategies.
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212001, P R, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Zhaoliang
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Bie
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China ; Department of Internal Medicine, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212001, P R, China.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China ; Department of Laboratory Medicine, Zhejiang Provincial Hospital of Traditional Chinese Medicine Hangzhou 310006, P R, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Hongqun
authors.initials: H
authors.lastname: Ding
authors.affiliation: Department of Internal Medicine, The Affiliated People's Hospital of Jiangsu University Zhenjiang 212001, P R, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.affiliation: Department of Immunology, School of Medicine, Jiangsu University Zhenjiang 212013, P R, China.
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D000067596:Interleukin-33 / Q000378:metabolism; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000276:immunology* / Q000378:metabolism; D010641:Phenotype; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation; D015854:Up-Regulation
chemical_list: D016207:Cytokines; C506536:IL33 protein, human; D000067596:Interleukin-33; D014157:Transcription Factors
keywords: Asthma; ILC2s; MDSCs; Th2 cells