title: Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos.
abstract: Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Si
authors.initials: S
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Yi
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
mesh_terms: D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D004622:Embryo, Mammalian / Q000378:metabolism*; D016678:Genome; D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000628:therapy*; D017393:RNA Editing / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial