title: Mitochondria-Targeted Plastoquinone Antioxidant SkQR1 Has Positive Effect on Memory of Rats.
abstract: A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 µmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.
authors.affiliation: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, 125367, Russia. estelmash@mail.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: A V
authors.initials: AV
authors.lastname: Stavrovskaya
authors.forename: N G
authors.initials: NG
authors.lastname: Yamshchikova
authors.forename: A S
authors.initials: AS
authors.lastname: Ol'shanskii
authors.forename: N A
authors.initials: NA
authors.lastname: Kapay
authors.forename: O V
authors.initials: OV
authors.lastname: Popova
authors.forename: L G
authors.initials: LG
authors.lastname: Khaspekov
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
mesh_terms: D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects*; D008928:Mitochondria / Q000378:metabolism*; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017966:Pyramidal Cells / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012235:Rhodamines / Q000494:pharmacology*
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; D012235:Rhodamines; D010971:Plastoquinone