title: Effects of treatment with fluoxetine on mandibular development: A morphological study in rats.
abstract: OBJECTIVE
  To verify whether the use of fluoxetine during gestation and lactation interferes in mandibular bone formation in rats.
  
  
  METHODS
  Twenty-four Wistar rat pups were used and distributed into four groups: CG - control of gestation; CL - control of gestation and lactation; FG - treated with fluoxetine during gestation and FL - treated with fluoxetine during gestation and lactation. At 25 days of life, after anesthesia, perfusion and decapitation, the mandibles were removed. Radiographic, histologic, histometric and polarizing microscopy analyses were performed. Statistical analysis was used considering a level of 5% significance.
  
  
  RESULTS
  The FL group compared with its control (CL) was shown to differ statistically from the other groups as regards histometry and radiopacity, revealing a reduction in the inferior cortical thickness, reduction in number of osteocytes, with consequent reduction in radiographic bone density. There was also reduction in the number of osteoblasts in FG.
  
  
  CONCLUSIONS
  The long-term use of fluoxetine via oral route by pregnant and lactating rats modifies the mandibular bone mass.
authors.affiliation: School of Dentistry, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: priscyllagcorreia@hotmail.com.
authors.forename: Priscylla Gonçalves
authors.initials: PG
authors.lastname: Correia-Leite de Marcelos
authors.affiliation: School of Dentistry, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: regueiraluciana@hotmail.com.
authors.forename: Luciana Silva
authors.initials: LS
authors.lastname: Regueira
authors.affiliation: School of Dentistry, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: isabelasantiago1@yahoo.com.br.
authors.forename: Isabela Maria
authors.initials: IM
authors.lastname: Santiago-Jaegger
authors.affiliation: School of Dentistry, Oral Pathology Section, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: danyel.perez@ufpe.br.
authors.forename: Danyel Elias
authors.initials: DE
authors.lastname: Cruz Perez
authors.affiliation: School of Dentistry, Oral Radiology Section, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: flavia.ramosperez@ufpe.br.
authors.forename: Flavia Maria
authors.initials: FM
authors.lastname: de Moraes Ramos-Perez
authors.affiliation: Department of Animal Morphology and Physiology: R. Dom Manoel de Medeiros, s/n, Dois Irmãos, CEP, 52171-900, Recife, PE, Brazil. Electronic address: evencioneto@bol.com.br.
authors.forename: Joaquim
authors.initials: J
authors.lastname: Evêncio Neto
authors.affiliation: Department of Histology and Embryology, Universidade Federal de Pernambuco, Av. Prof. Moraes, Rego, 1235, CEP, 50670-901, Recife, PE, Brazil. Electronic address: liriane@uol.com.br.
authors.forename: Liriane
authors.initials: L
authors.lastname: Baratella-Evêncio
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D008334:Mandible / Q000187:drug effects* / Q000196:embryology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005473:Fluoxetine
keywords: Antidepressants; Bone; Fluoxetine; Mandible; Serotonin