title: Selecting the proper pediatric dose: It is more than size that matters.
abstract: Appropriate pediatric dose selection remains one of the most vexing clinical problems faced by healthcare professionals who are charged to provide medical care to infants and children. While body size does reflect the ontogeny of processes that govern drug disposition, there are extremes of disease that perturb the expected relationships.
authors.affiliation: Arkansas Children's Hospital Research Institute and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Kearns
mesh_terms: D000367:Age Factors; D049628:Body Size; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D061214:Patient Safety; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004364:Pharmaceutical Preparations