title: Impact of Multilevel Surgical Treatment on Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome.
abstract: OBJECTIVE
  Mean platelet volume (MPV) is a potential marker of platelet reactivity. Increased MPV levels are shown to be the predictor of cardiovascular diseases, hypertension, and stroke. Previous studies demonstrated increased MPV levels in patients with obstructive sleep apnea syndrome (OSAS). The aim of this study was to examine the impact of 1-stage multilevel surgical treatment on MPV levels in patients with OSAS.
  
  
  METHODS
  Preoperative and postoperative 6-month hematologic parameters as well as polysomnographic findings of 42 patients, who underwent 1-stage multilevel surgery for treatment of moderate or severe OSAS, were compared.
  
  
  RESULTS
  In the comparisons of preoperative and postoperative apnea-hypopnea index (AHI) and MPV values, statistically significant decreases were detected There was a significant positive correlation between the decrease in mean AHI and decrease in MPV levels.
  
  
  CONCLUSIONS
  One-stage multilevel surgery targeting the obstruction at the retropalatal and tongue-base levels was found to be effective in decreasing AHI and MPV. Mean platelet volume may be a new index to indicate the success of OSAS surgery.
authors.affiliation: *Department of Otolaryngology, Ondokuz Mayis University Faculty of Medicine, Samsun †Department of Physiology, Hacettepe University Faculty of Medicine ‡Department of Otolaryngology, Gazi University Faculty of Medicine, Ankara §Department of Otolaryngology, Muş Malazgirt State Hospital, Muş, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Günbey
authors.forename: Ismail
authors.initials: I
authors.lastname: Karabulut
authors.forename: Hayriye
authors.initials: H
authors.lastname: Karabulut
authors.forename: Murat
authors.initials: M
authors.lastname: Zaim
mesh_terms: D001792:Blood Platelets; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods*; D008875:Middle Aged; D017286:Polysomnography; D019651:Plastic Surgery Procedures / Q000379:methods*; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000175:diagnosis / Q000601:surgery*