title: Can We Identify Patients with High Risk of Osteoarthritis Progression Who Will Respond to Treatment? A Focus on Biomarkers and Frailty.
abstract: Osteoarthritis (OA), a disease affecting different patient phenotypes, appears as an optimal candidate for personalized healthcare. The aim of the discussions of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group was to explore the value of markers of different sources in defining different phenotypes of patients with OA. The ESCEO organized a series of meetings to explore the possibility of identifying patients who would most benefit from treatment for OA, on the basis of recent data and expert opinion. In the first meeting, patient phenotypes were identified according to the number of affected joints, biomechanical factors, and the presence of lesions in the subchondral bone. In the second meeting, summarized in the present article, the working group explored other markers involved in OA. Profiles of patients may be defined according to their level of pain, functional limitation, and presence of coexistent chronic conditions including frailty status. A considerable amount of data suggests that magnetic resonance imaging may also assist in delineating different phenotypes of patients with OA. Among multiple biochemical biomarkers identified, none is sufficiently validated and recognized to identify patients who should be treated. Considerable efforts are also being made to identify genetic and epigenetic factors involved in OA, but results are still limited. The many potential biomarkers that could be used as potential stratifiers are promising, but more research is needed to characterize and qualify the existing biomarkers and to identify new candidates.
authors.affiliation: NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.
authors.forename: Nigel
authors.initials: N
authors.lastname: Arden
authors.forename: Pascal
authors.initials: P
authors.lastname: Richette
authors.forename: Cyrus
authors.initials: C
authors.lastname: Cooper
authors.forename: Olivier
authors.initials: O
authors.lastname: Bruyère
authors.forename: Eric
authors.initials: E
authors.lastname: Abadie
authors.forename: Jaime
authors.initials: J
authors.lastname: Branco
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Brandi
authors.forename: Francis
authors.initials: F
authors.lastname: Berenbaum
authors.forename: Cécile
authors.initials: C
authors.lastname: Clerc
authors.forename: Elaine
authors.initials: E
authors.lastname: Dennison
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Devogelaer
authors.forename: Marc
authors.initials: M
authors.lastname: Hochberg
authors.forename: Pieter
authors.initials: P
authors.lastname: D'Hooghe
authors.forename: Gabriel
authors.initials: G
authors.lastname: Herrero-Beaumont
authors.forename: John A
authors.initials: JA
authors.lastname: Kanis
authors.forename: Andrea
authors.initials: A
authors.lastname: Laslop
authors.forename: Véronique
authors.initials: V
authors.lastname: Leblanc
authors.forename: Stefania
authors.initials: S
authors.lastname: Maggi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mautone
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
authors.forename: Florence
authors.initials: F
authors.lastname: Petit-Dop
authors.forename: Susanne
authors.initials: S
authors.lastname: Reiter-Niesert
authors.forename: René
authors.initials: R
authors.lastname: Rizzoli
authors.forename: Lucio
authors.initials: L
authors.lastname: Rovati
authors.forename: Eleonora
authors.initials: E
authors.lastname: Tajana Messi
authors.forename: Yannis
authors.initials: Y
authors.lastname: Tsouderos
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Reginster
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010003:Osteoarthritis / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011237:Predictive Value of Tests; D012307:Risk Factors
chemical_list: D015415:Biomarkers