title: Schisandrin C Ameliorates Learning and Memory Deficits by Aβ1-42-induced Oxidative Stress and Neurotoxicity in Mice.
abstract: Schisandrin C (SCH-C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize the effect of SCH-C on memory impairment and further research on pathological changes in Aβ1-42-induced Alzheimer's disease mice. Mice were administration with SCH-C daily for 5 days in the lateral cerebral ventricles using sterotaxically implanted cannula. Cognitive functions were assessed by Y-maze test, active avoidance test and Morris water maze test in all groups, and the level of Aβ1-42and neuronal injury induced by Aβ1-42were reversed remarkably following SCH-C treatment compared with sham group; meanwhile the impairment of short-term or working memory was dramatically improved. In addition, SCH-C significantly inhibited total cholinesterase (ChEtotal), and increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activity glutathione (GSH) levels in the hippocampus and cerebral cortex. It can be speculated that SCH-C offers protection against Aβ1-42-induced dysfunction in learning and memory by inhibiting ChEtotal and its antioxidant action. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Mao
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Mengjie
authors.initials: M
authors.lastname: Xu
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhao
authors.affiliation: The Engineering Laboratory of National and Local Union of Quality Control for Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Kaishun
authors.initials: K
authors.lastname: Bi
authors.affiliation: Shenyang Key Laboratory of Active Components of Chinese Medicine Screening and Evaluation, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jia
keywords: Alzheimer's disease; Aβ1-42; antioxidant; intracerebroventricular injection; neuroprotective effect; schisandrin C