title: Novel Application of 3-Dimensional Real-Time Cardiac Imaging to Guide Stem Cell-Based Therapy.
abstract: Stem cell-based therapy is an emerging treatment for refractory ischemic cardiomyopathy. The transendocardial approach represents the most attractive method that allows direct percutaneous injections of the cell product into the ischemic territories. This clinical case shows a novel strategy designed to optimize cell endocardial delivery, based on the implementation of the 3-dimensional electroanatomical map with the intracardiac-echocardiographic reconstruction of the left ventricle, using acquired multiple slice recordings. Combined imaging was efficacious to detail the anatomical and functional characteristics of the target areas and to guide cell delivery supported by direct real-time visualization of the needle to improve procedural effectiveness and safety.
authors.affiliation: Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino - IRCCS, Milan, Italy. Electronic address: corrado.carbucicchio@ccfm.it.
authors.forename: Corrado
authors.initials: C
authors.lastname: Carbucicchio
authors.affiliation: Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino - IRCCS, Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Casella
authors.affiliation: Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino - IRCCS, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Catto
authors.affiliation: Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino - IRCCS, Milan, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Bassetti
authors.affiliation: "L. Sacco" Department of Clinical and Biomedical Sciences, Università degli Studi di Milano, Casa di Cura San Pio X, Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bestetti
authors.affiliation: Vascular Biology and Regenerative Medicine Unit, Centro Cardiologico Monzino - IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
authors.forename: Giulio
authors.initials: G
authors.lastname: Pompilio
mesh_terms: D006328:Cardiac Catheterization; D009202:Cardiomyopathies / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D033581:Stem Cell Transplantation / Q000379:methods*; D025321:Surgery, Computer-Assisted / Q000379:methods*