title: Selective Michael Reaction Controlled by Supersilyl Protecting Group.
abstract: Selective Michael reaction of organolithium reagents to supersilyl methacrylate is reported. The method was able to control a single and double Michael addition. The successful termination of the process using the supersilyl protecting group allows for the controlled, chemoselective, and diastereoselective Michael reaction.
authors.affiliation: Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501 (Japan). izumiseki@isc.chubu.ac.jp.
authors.forename: Atsuto
authors.initials: A
authors.lastname: Izumiseki
authors.affiliation: Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501 (Japan). hyamamoto@isc.chubu.ac.jp.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D060326:Chemistry Techniques, Synthetic; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry*; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D008689:Methacrylates; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D008094:Lithium
keywords: Michael reaction; chemoselectivity; protecting groups; supersilyl group; synthetic methods