title: Orchestrating liver development.
abstract: The liver is a central regulator of metabolism, and liver failure thus constitutes a major health burden. Understanding how this complex organ develops during embryogenesis will yield insights into how liver regeneration can be promoted and how functional liver replacement tissue can be engineered. Recent studies of animal models have identified key signaling pathways and complex tissue interactions that progressively generate liver progenitor cells, differentiated lineages and functional tissues. In addition, progress in understanding how these cells interact, and how transcriptional and signaling programs precisely coordinate liver development, has begun to elucidate the molecular mechanisms underlying this complexity. Here, we review the lineage relationships, signaling pathways and transcriptional programs that orchestrate hepatogenesis.
authors.affiliation: Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Gordillo
authors.affiliation: Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Todd
authors.initials: T
authors.lastname: Evans
authors.affiliation: Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA valerie.gouon-evans@mssm.edu.
authors.forename: Valerie
authors.initials: V
authors.lastname: Gouon-Evans
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D022781:Hepatocytes / Q000166:cytology*; D006801:Humans; D008099:Liver / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D008107:Liver Diseases / Q000473:pathology; D051379:Mice; D038081:Organogenesis / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*
keywords: Cholangiocyte; Hepatoblast; Hepatocyte; Liver development; Transcription factors