title: Pathogenesis of Crohn's disease.
abstract: Significant progress in our understanding of Crohn's disease (CD), an archetypal common, complex disease, has now been achieved. Our ability to interrogate the deep complexities of the biological processes involved in maintaining gut mucosal homeostasis is a major over-riding factor underpinning this rapid progress. Key studies now offer many novel and expansive insights into the interacting roles of genetic susceptibility, immune function, and the gut microbiota in CD. Here, we provide overviews of these recent advances and new mechanistic themes, and address the challenges and prospects for translation from concept to clinic.
authors.affiliation: Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh Edinburgh, EH16 4TJ UK ; Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, EH4 2XU UK.
authors.forename: Ray
authors.initials: R
authors.lastname: Boyapati
authors.affiliation: Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh Edinburgh, EH16 4TJ UK ; Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, EH4 2XU UK.
authors.forename: Jack
authors.initials: J
authors.lastname: Satsangi
authors.affiliation: Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh Edinburgh, EH16 4TJ UK ; Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, EH4 2XU UK.
authors.forename: Gwo-Tzer
authors.initials: GT
authors.lastname: Ho