title: Obesity and Altered Sleep: A Pathway to Metabolic Derangements in Children?
abstract: Obstructive sleep apnea (OSA) is a frequent disorder in children and is primarily associated with adenotonsillar hypertrophy. The prominent increases in childhood overweight and obesity rates in the world even among youngest of children have translated into parallel increases in the prevalence of OSA, and such trends are undoubtedly associated with deleterious global health outcomes and life expectancy. Even an obesity phenotype in childhood OSA, more close to the adult type, has been recently proposed. Reciprocal interactions between sleep in general, OSA, obesity, and disruptions of metabolic homeostasis have emerged in recent years. These associations have suggested the a priori involvement of complex sets of metabolic and inflammatory pathways, all of which may underlie an increased risk for increased orexigenic behaviors and dysfunctional satiety, hyperlipidemia, and insulin resistance that ultimately favor the emergence of metabolic syndrome. Here, we review some of the critical evidence supporting the proposed associations between sleep disruption and the metabolism-obesity complex. In addition, we describe the more recent evidence linking the potential interactive roles of OSA and obesity on metabolic phenotype.
authors.affiliation: Pediatric Pulmonary Institute, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Fahed
authors.initials: F
authors.lastname: Hakim
authors.affiliation: Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois.
authors.forename: Leila
authors.initials: L
authors.lastname: Kheirandish-Gozal
authors.affiliation: Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois. Electronic address: dgozal@uchicago.edu.
authors.forename: David
authors.initials: D
authors.lastname: Gozal
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D008659:Metabolic Diseases / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology; D012893:Sleep Wake Disorders / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology