title: 4-Substituted-2-Methoxyphenol: Suitable Building Block to Prepare New Bioactive Natural-like Hydroxylated Biphenyls.
abstract: A small collection of eugenol- and curcumin-analog hydroxylated biphenyls was prepared by straightforward methods starting from natural 4-substituted-2-methoxyphenols and their antitumoral activity was evaluatedin vitro. Two curcumin-biphenyl derivatives showed interesting growth inhibitory activities on different malignant melanoma cell lines with IC50ranging from 13 to 1 µM. Preliminary molecular modeling studies were carried out to evaluate conformations and dihedral angles suitable for antiproliferative activity in hydroxylated biphenyls bearing a side aliphatic chain.
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Dettori
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Fabbri
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Pisano
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Rozzo
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Palmieri
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dess
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Dallocchio
authors.affiliation: CNR-Istituto di Chimica Biomolecolare, UOS Sassari, Traversa La Crucca 3, 07100 Sassari-Baldinca Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Delogu
keywords: Curcumin; dihedral angle; hydroxylated biphenyls; malignant melanoma; synthesis.