title: Diabetes and obesity not associated with 6-month remission rates for primary care patients with depression.
abstract: BACKGROUND
  Complex interrelationships appear to exist among depression, diabetes, and obesity, and it has been proposed that both diabetes and obesity have an association with depression.
  
  
  OBJECTIVE
  The purpose of our study was to explore the effect of obesity and diabetes on response to the treatment of depression. Our hypothesis was that obesity and the diagnosis of diabetes in primary care patients with depression would have no effects on depression remission rates 6 months after diagnosis.
  
  
  METHODS
  A retrospective chart review analysis of 1894 adult (age ≥18y) primary care patients diagnosed with major depressive disorder or dysthymia and a Patient Health Questionnaire-9 score ≥10 from January 1, 2008, through September 30, 2012. Multiple logistic regression modeling retaining all independent variables was performed for the outcome of remission (Patient Health Questionnaire-9 < 5) 6 months after diagnosis.
  
  
  RESULTS
  The presence of obesity (odds ratio = 0.937, 95% CI: 0.770-1.140, p = 0.514) or the diagnosis of diabetes (odds ratio = 0.740, 95% CI: 0.535-1.022, p = 0.068) did not affect the likelihood of remission, while controlling for the other independent variables.
  
  
  CONCLUSIONS
  In primary care patients treated for depression, the presence of diabetes or obesity at the time of diagnosis of depression does not appear to significantly affect remission of depressive symptoms 6 months after diagnosis.
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Todd W
authors.initials: TW
authors.lastname: Wade
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Sara S
authors.initials: SS
authors.lastname: Oberhelman
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN. Electronic address: angstman.kurt@mayo.edu.
authors.forename: Kurt B
authors.initials: KB
authors.lastname: Angstman
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
authors.forename: Craig N
authors.initials: CN
authors.lastname: Sawchuk
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Meunier
authors.affiliation: Department of Family Medicine, Mayo Clinic Health System-Austin, Austin, MN.
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Angstman
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN.
authors.forename: James E
authors.initials: JE
authors.lastname: Rohrer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology / Q000628:therapy*; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000523:psychology; D011320:Primary Health Care; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult