title: Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines.
abstract: A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt, CNRS UMR 5253, AM2N, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 05, France. marc.taillefer@enscm.fr florian.monnier@enscm.fr.
authors.forename: Janet
authors.initials: J
authors.lastname: Bahri
authors.forename: Rémi
authors.initials: R
authors.lastname: Blieck
authors.forename: Bassem
authors.initials: B
authors.lastname: Jamoussi
authors.forename: Marc
authors.initials: M
authors.lastname: Taillefer
authors.forename: Florian
authors.initials: F
authors.lastname: Monnier
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000588:Amines; D003300:Copper