title: miSEA: microRNA set enrichment analysis.
abstract: We introduce a novel web-based tool, miSEA, for evaluating the enrichment of relevant microRNA sets from microarray and miRNA-Seq experiments on paired samples, e.g. control vs.
  
  
  METHODS
  In addition to a group of previously annotated microRNA sets embedded in the system, this tool enables users to import new microRNA sets obtained from their own research. miSEA allows users to select from a large variety of microRNA grouping categories, such as family classification, disease association, common regulation, and genome coordinates, based on their requirements. miSEA therefore provides a knowledge-driven representation scheme for microRNA experiments. The usability of this platform was discerned with a cancer type-classification task performed on a set of real microRNA expression profiling experiments. The miSEA web server is available at http://www.baskent.edu.tr/∼hogul/misea.
authors.affiliation: Department of Computer Engineering, Baskent University, Ankara, Turkey; Department of Technology and Information Management, Baskent University, Ankara, Turkey.
authors.forename: M Erdem
authors.initials: ME
authors.lastname: Çorapçıoğlu
authors.affiliation: Department of Computer Engineering, Baskent University, Ankara, Turkey. Electronic address: hogul@baskent.edu.tr.
authors.forename: Hasan
authors.initials: H
authors.lastname: Oğul
mesh_terms: D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: Gene set analysis; Microarray analysis; miRNA-Seq data analysis; microRNA expression profiling