title: Common Aging Signature in the Peripheral Blood of Vascular Dementia and Alzheimer's Disease.
abstract: Alzheimer's disease (AD) and vascular dementia (VaD) are the two most dominant forms of dementia in elderly people. Due to the large overlap between AD and VaD in clinical observations, great controversies exist regarding the distinction and connection between these two types of senile dementia. Here for the first time, we resort to the gene expression pattern of the peripheral blood to compare AD and VaD objectively. In our previous work, we have demonstrated that the dysregulation of gene expression in AD is unique among the examined diseases including neurological diseases, cancer, and metabolic diseases. In this study, we found that the dysregulation of gene expression in AD and VaD is quite similar to each other at both functional and gene levels. Interestingly, the dysregulation started at the early stages of the diseases, namely mild cognitive impairment (MCI) and vascular cognitive impairment (VCI). We have also shown that this signature is distinctive from that of peripheral vascular diseases. Comparison with aging studies revealed that the most profound change in AD and VaD, namely ribosome, is consistent with the accelerated aging scenario. This study may have implications to the common mechanism between AD and VaD.
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou military Area Command, Lanzhou, Gansu, 730050, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Luo
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
authors.forename: Guangchun
authors.initials: G
authors.lastname: Han
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 100053, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou military Area Command, Lanzhou, Gansu, 730050, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou military Area Command, Lanzhou, Gansu, 730050, China.
authors.forename: Shaoju
authors.initials: S
authors.lastname: Shao
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Fuhai
authors.initials: F
authors.lastname: Song
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Zhouxian
authors.initials: Z
authors.lastname: Bai
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.|University of Chinese Academy of Sciences, Beijing, 100049, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 100053, China.
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Lanzhou General Hospital, Lanzhou military Area Command, Lanzhou, Gansu, 730050, China. shixq_2003@163.com.
authors.forename: Xiangqun
authors.initials: X
authors.lastname: Shi
authors.affiliation: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. leihx@big.ac.cn.|Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China. leihx@big.ac.cn.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Lei
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood* / Q000235:genetics; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics; D030541:Databases, Genetic; D015140:Dementia, Vascular / Q000097:blood* / Q000235:genetics; D018450:Disease Progression; D020869:Gene Expression Profiling; D006801:Humans; D000067616:S100A12 Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D000067616:S100A12 Protein; C090441:S100A12 protein, human
keywords: Alzheimer’s disease; Gene expression; Peripheral blood; Ribosome; Vascular dementia