title: A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates.
abstract: OBJECTIVE
  Optical coherence tomography (OCT) is a non-invasive imaging method widely used in ophthalmology. Recent developments have produced OCT devices for imaging the skin. The purpose of this study was to investigate Fourier Domain OCT morphological features of periocular basal cell carcinoma (BCC) in correlation with conventional histopathology.
  
  
  METHODS
  Consecutive patients with periocular nodular BCC were prospectively examined with VivoSight OCT (Michelson Ltd) prior to surgical excision. OCT slice mode images were analysed using criteria defined for conventional and HD-OCT; the images were correlated to haematoxylin and eosin stained histology sections.
  
  
  RESULTS
  A total of 15 patients with periocular BCC were recruited. Three categories of BCC morphological features were identified from slice mode OCT images: (1) Epidermal changes included epidermal thinning (15/15; 100%), ulceration and crusting (5/15, 33.3%) and decreased density of hair follicles (8/15; 53.3%); (2) Intralesional features included hyporeflective nodules (15/15; 100%), hyper-reflective edges (15/15; 100%) and hyporeflective central necrosis (3/15; 20%) (3) Perilesional features included hyporeflective borders (11/15; 73%), hypereflective margins (15/15; 100%) and dilated blood vessels (5/15; 33%).
  
  
  CONCLUSIONS
  This study demonstrated that Fourier Domain OCT imaging offers additional information in the identification of morphological features of nodular BCC compared to conventional OCT diagnostic criteria. VivoSight produced fast, non-invasive imaging of skin lesions in the periocular region and high correlation with histology. Further studies are necessary to investigate OCT features of different histological subtypes of BCC.
authors.affiliation: Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK.
authors.forename: L
authors.initials: L
authors.lastname: Pelosini
authors.affiliation: Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK.
authors.forename: H B
authors.initials: HB
authors.lastname: Smith
authors.affiliation: Histopathology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK.
authors.forename: J B
authors.initials: JB
authors.lastname: Schofield
authors.affiliation: Michaelson Diagnostics Ltd, 11A Grays Farm Production Village, Orpington, Kent, UK.
authors.forename: A
authors.initials: A
authors.lastname: Meeckings
authors.affiliation: Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK.
authors.forename: A
authors.initials: A
authors.lastname: Dithal
authors.affiliation: Ophthalmology Department, Maidstone & Tunbridge Wells NHS Trust, Maidstone, Kent, UK.
authors.forename: M
authors.initials: M
authors.lastname: Khandwala
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis*; D005153:Facial Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*