title: Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients.
abstract: BACKGROUND
  Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV1, but their clinical significance in adult CF patients is poorly characterized.
  
  
  METHODS
  We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV1, rate of pulmonary exacerbations, CRP levels and clinical scores).
  
  
  RESULTS
  In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA.
  
  
  CONCLUSIONS
  In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease.
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. heather.ahlgren@gmail.com.
authors.forename: Heather G
authors.initials: HG
authors.lastname: Ahlgren
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. Andrea.Benedetti@mcgill.ca.|Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Canada. Andrea.Benedetti@mcgill.ca.|Respiratory Epidemiology and Clinical Research Unit, McGill University Health Center, Montreal, Canada. Andrea.Benedetti@mcgill.ca.
authors.forename: Andrea
authors.initials: A
authors.lastname: Benedetti
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. jennifer.landry@mcgill.ca.|Respiratory Epidemiology and Clinical Research Unit, McGill University Health Center, Montreal, Canada. jennifer.landry@mcgill.ca.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Landry
authors.affiliation: Adult CF clinic, McGill University Health Center, Montreal, Canada. joanie_bernier1@hotmail.com.
authors.forename: Joanie
authors.initials: J
authors.lastname: Bernier
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. elias.matouk@mcgill.ca.|Adult CF clinic, McGill University Health Center, Montreal, Canada. elias.matouk@mcgill.ca.
authors.forename: Elias
authors.initials: E
authors.lastname: Matouk
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. danuta.radzioch@mcgill.ca.|Department of Medicine, McGill University Health Center Research Institute, Montreal, Canada. danuta.radzioch@mcgill.ca.|Department of Human Genetics, McGill University, Montreal, Canada. danuta.radzioch@mcgill.ca.
authors.forename: Danuta
authors.initials: D
authors.lastname: Radzioch
authors.affiliation: Department of Pediatrics, McGill University Health Center Research Institute, Montreal, Canada. larry.lands@mcgill.ca.
authors.forename: Larry C
authors.initials: LC
authors.lastname: Lands
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. Simon.Rousseau@mcgill.ca.|Department of Medicine, McGill University Health Center Research Institute, Montreal, Canada. Simon.Rousseau@mcgill.ca.
authors.forename: Simon
authors.initials: S
authors.lastname: Rousseau
authors.affiliation: Department of Medicine, McGill University, Montreal, Canada. dao.nguyen@mcgill.ca.|Department of Medicine, McGill University Health Center Research Institute, Montreal, Canada. dao.nguyen@mcgill.ca.
authors.forename: Dao
authors.initials: D
authors.lastname: Nguyen
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000276:immunology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011552:Pseudomonas Infections / Q000453:epidemiology*; D011550:Pseudomonas aeruginosa; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013183:Sputum / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013211:Staphylococcus aureus; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein