title: Social Experience-Dependent Myelination: An Implication for Psychiatric Disorders.
abstract: Myelination is one of the strategies to promote the conduction velocity of axons in order to adjust to evolving environment in vertebrates. It has been shown that myelin formation depends on genetic programing and experience, including multiple factors, intracellular and extracellular molecules, and neuronal activities. Recently, accumulating studies have shown that myelination in the central nervous system changes more dynamically in response to neuronal activities and experience than expected. Among experiences, social experience-dependent myelination draws attention as one of the critical pathobiologies of psychiatric disorders. In this review, we summarize the mechanisms of neuronal activity-dependent and social experience-dependent myelination and discuss the contribution of social experience-dependent myelination to the pathology of psychiatric disorders.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Toritsuka
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, Japan.
authors.forename: Manabu
authors.identifier: 0000-0003-4339-9413
authors.initials: M
authors.lastname: Makinodan
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, Japan.
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000503:physiopathology*; D009186:Myelin Sheath / Q000502:physiology*; D009431:Neural Conduction; D020890:Neuregulin-1 / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D012919:Social Behavior
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C094131:NRG1 protein, human; D020890:Neuregulin-1; C579455:BDNF protein, human