title: Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects.
abstract: The principal pathogenesis of coronary artery disease (CAD) is coronary artery atherosclerosis, a chronic inflammatory disease of the vessel walls of the coronary artery. Intercellular adhesion molecule-1 (ICAM-1) displays an important role in the development of the inflammation reaction and atherosclerosis. Few studies report the association of ICAM-1 genetic polymorphisms with CAD in Taiwanese subjects. Therefore, we conducted a study to associate the single nucleotide polymorphisms (SNPs) of ICAM-1, rs5491, rs5498, rs281432 and rs3093030 with CAD. Five hundred and twenty-five male and female subjects, who received elective coronary angiography in Taiwan Chung Shan Medical University Hospital, were recruited to determine four ICAM-1 SNPs by real time-polymerase chain reaction and genotyping. The relationships among ICAM-1 SNPs, haplotypes, demographic and characteristics and CAD were analyzed. This study showed that rs281432 (C8823G) was the only ICAM-1 SNP which affect the development of CAD. Multivariate analysis revealed that ICAM-1 SNP rs281432 CC/CG [p=0.016; odds ratio (OR): 2.56, 95% confidence interval (CI): 1.19-5.56], male gender (p=0.018; OR: 1.66, 95% CI: 1.09-2.51), aspirin use in the past 7 days (p=0.001; OR: 2.05, 95% CI: 1.33-3.14), hypertension (p<0.001; OR: 2.15, 95% CI: 1.42-3.25), serum cardiac troponin I elevation (p<0.001; OR: 2.14, 95% CI: 1.47-3.24) and severe angina in recent 24 hours (p=0.001; OR: 1.97, 95% CI: 1.31- 2.95) increase the risk of CAD. In conclusion, ICAM-1 SNP rs281432 is an independent factor to predict the development of CAD. ICAM-1 SNP rs281432 homozygotic mutant GG can reduce the susceptibility to the CAD in Taiwanese subjects.
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University,110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan ; 2. Division of Cardiology, Department of Internal Medicine, Yuan-Sheng Hospital and Changhua Christian Hospital, Yuanlin Branch, Yuanlin, Taiwan.
authors.forename: Chi-Hung
authors.initials: CH
authors.lastname: Chou
authors.affiliation: 3. Department of Internal Medicine, Chung Shan Medical University Hospital, 110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan ; 4. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Kwo-Chang
authors.initials: KC
authors.lastname: Ueng
authors.affiliation: 5. Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Liu
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University,110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan.
authors.forename: Chih-Hsien
authors.initials: CH
authors.lastname: Wu
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University,110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan ; 6. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan.
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
authors.affiliation: 1. Institute of Medicine, Chung Shan Medical University,110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan ; 4. School of Medicine, Chung Shan Medical University, Taichung, Taiwan ; 7. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Po-Hui
authors.initials: PH
authors.lastname: Wang
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000235:genetics* / Q000503:physiopathology; D003331:Coronary Vessels; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan
chemical_list: D018799:Intercellular Adhesion Molecule-1
keywords: Coronary artery disease; Taiwanese.; genetic polymorphism; haplotype; intercellular adhesion molecule-1; rs281432