title: [Calcium and vitamin D in osteology].
abstract: Calcium homeostasis is of paramount physiological and pathophysiological importance in health and disease. This article focuses on the skeletal relevance of calcium and vitamin D in daily clinical practice. Against the background of an endemic vitamin D deficiency in Germany and the increasing number of patients with drug-induced (proton pump inhibitor) enteral calcium uptake problems, it is of critical importance to understand that a vitamin D level of > 30 µg/l (> 75 nmol/l) is required for intact skeletal mineralization and that furthermore, a physiological gastric acid production is essential for a normal enteral uptake of calcium from foodstuffs. Therefore, a guideline-conform handling of vitamin D and calcium substitution is required not only for patients with rheumatoid diseases but also for any osteological therapy.
authors.affiliation: Institut für Osteologie und Biomechanik (IOBM), Universitätsklinikum Hamburg Eppendorf, Lottestr. 59, 22529, Hamburg, Deutschland, amling@uke.de.
authors.forename: M
authors.initials: M
authors.lastname: Amling
authors.forename: F
authors.initials: F
authors.lastname: Barvencik
mesh_terms: D001846:Bone Development; D001847:Bone Diseases / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D002118:Calcium