title: The nature of neonatal status epilepticus--a clinician's perspective.
abstract: Neonatal status epilepticus occurs within the substrate of the hyperexcitable newborn brain and is usually provoked by acute CNS derangements, although status can also be the presentation of early-life epilepsy. Provoked neonatal status usually resolves within a few days, with or without treatment, but new data suggests that status is associated with adverse outcomes, even after controlling for underlying disease severity and MRI structural brain injury. Novel treatments may be needed to improve seizure control and outcome, given the characteristics of neurotransmission in the newborn brain. This article is part of a Special Issue entitled "Status Epilepticus".
authors.affiliation: Division of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, 34th Street and Civic Center Boulevard, Colket Translational Research Building, 10th floor, Philadelphia, PA 19104, USA. Electronic address: dlugos@email.chop.edu.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Dlugos
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D010819:Physician's Role; D013226:Status Epilepticus / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology*
chemical_list: D000890:Anti-Infective Agents
keywords: Neonatal seizures; Status epilepticus