title: [Diagnostic algorithm for von Willebrand Disease (vWD) in a Mexican population].
abstract: The diagnosis of von Willebrand disease (vWD) is complex and requires several screening and confirmation tests, such as the analysis of vWF multimers, which is considered the gold standard for vWD subtyping; however, it only discriminates 2A subtype while the 2B, 2M, and 2N subtypes require additional tests and even genetic testing for final confirmation. It is important to consider the patients’ hemotype for the vWD diagnosis, particularly in Mexico where hemotype “O” predominates and may entail a 20-25% decreased level of plasma vWF and increased bleeding tendency.
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jal., México.|Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., México.
authors.forename: María Guadalupe
authors.initials: MG
authors.lastname: Zavelia Padilla-Romo
authors.affiliation: División de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jal., México.
authors.forename: Ana Rebeca
authors.initials: AR
authors.lastname: Jaloma-Cruz
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis; D000465:Algorithms; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008800:Mexico; D014842:von Willebrand Diseases / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D000017:ABO Blood-Group System