title: Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice.
abstract: OBJECTIVE
  To determine the therapeutic efficacy of resveratrol on ulcerative colitis (UC) and its underlying mechanisms.
  
  
  METHODS
  The mouse UC model was developed using 5% dextran sulfate sodium. Mice were randomly divided into four groups: normal control, UC model group, resveratrol low-dose group (RLD; 50 mg/kg per day), and resveratrol high-dose group (RHD; 100 mg/kg per day).
  
  
  RESULTS
  The results showed that RLD regulates Treg/Th17 balance mainly through reducing the number of Th17 cells, whereas RHD regulates Treg/Th17 balance through both downregulating the number of Th17 cells and upregulating the number of Treg cells. Resveratrol can also regulate the level of plasma and intestinal mucosal cytokines including interleukin (IL)-10, transforming growth factor-β1, IL-6, and IL-17. The expressions of hypoxia inducible factor (HIF)-1α, mammalian target of rapamycin (mTOR), and signal transducer and activator of transcription 3 were significantly decreased in the intestinal tissues of mice treated with resveratrol.
  
  
  CONCLUSIONS
  The therapeutic efficacy of resveratrol in UC is dose dependent and closely associated with the regulation of Treg/Th17 balance and the HIF-1α/mTOR signaling pathway.
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wei
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Jian-Yao
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Ying-Xue
authors.initials: YX
authors.lastname: Li
authors.affiliation: Jun Yao, Cheng Wei, Ru Zhang, Ying-Xue Li, Li-sheng Wang, Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen 518020, Guangdong Province, China.
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Wang
mesh_terms: D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D003106:Colon / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008807:Mice, Inbred BALB C; D000077185:Resveratrol; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D013997:Time Factors
chemical_list: D016207:Cytokines; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D018836:Inflammation Mediators; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D013267:Stilbenes; D016264:Dextran Sulfate; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases; D000077185:Resveratrol
keywords: Hypoxia inducible factor-α; Mammalian target of rapamycin; Resveratrol; Th17 cells; Treg cells; Ulcerative colitis