title: Mitochondrial ROS Metabolism: 10 Years Later.
abstract: The role of mitochondria in oxidative stress is well recognized, but many questions are still to be answered. This article is intended to update our comprehensive review in 2005 by highlighting the progress in understanding of mitochondrial reactive oxygen species (ROS) metabolism over the past 10 years. We review the recently identified or re-appraised sources of ROS generation in mitochondria, such as p66(shc) protein, succinate dehydrogenase, and recently discovered properties of the mitochondrial antioxidant system. We also reflect upon some controversies, disputes, and misconceptions that confound the field.
authors.affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0601, USA. alex_andreyev@mitoexperts.com.
authors.forename: A Y
authors.initials: AY
authors.lastname: Andreyev
authors.forename: Y E
authors.initials: YE
authors.lastname: Kushnareva
authors.forename: A N
authors.initials: AN
authors.lastname: Murphy
authors.forename: A A
authors.initials: AA
authors.lastname: Starkov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D024101:Mitochondrial Proteins; D017382:Reactive Oxygen Species