title: Statistical Biomechanical Surface Registration: Application to MR-TRUS Fusion for Prostate Interventions.
abstract: A common challenge when performing surface-based registration of images is ensuring that the surfaces accurately represent consistent anatomical boundaries. Image segmentation may be difficult in some regions due to either poor contrast, low slice resolution, or tissue ambiguities. To address this, we present a novel non-rigid surface registration method designed to register two partial surfaces, capable of ignoring regions where the anatomical boundary is unclear. Our probabilistic approach incorporates prior geometric information in the form of a statistical shape model (SSM), and physical knowledge in the form of a finite element model (FEM). We validate results in the context of prostate interventions by registering pre-operative magnetic resonance imaging (MRI) to 3D transrectal ultrasound (TRUS). We show that both the geometric and physical priors significantly decrease net target registration error (TRE), leading to TREs of 2.35 ± 0.81 mm and 2.81 ± 0.66 mm when applied to full and partial surfaces, respectively. We investigate robustness in response to errors in segmentation, varying levels of missing data, and adjusting the tunable parameters. Results demonstrate that the proposed surface registration method is an efficient, robust, and effective solution for fusing data from multiple modalities.
authors.forename: Siavash
authors.initials: S
authors.lastname: Khallaghi
authors.forename: C Antonio
authors.initials: CA
authors.lastname: Sánchez
authors.forename: Abtin
authors.initials: A
authors.lastname: Rasoulian
authors.forename: Saman
authors.initials: S
authors.lastname: Nouranian
authors.forename: Cesare
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Abdi
authors.forename: Silvia D
authors.initials: SD
authors.lastname: Chang
authors.forename: Peter C
authors.initials: PC
authors.lastname: Black
authors.forename: Larry
authors.initials: L
authors.lastname: Goldenberg
authors.forename: William J
authors.initials: WJ
authors.lastname: Morris
authors.forename: Ingrid
authors.initials: I
authors.lastname: Spadinger
authors.forename: Aaron
authors.initials: A
authors.lastname: Fenster
authors.forename: Aaron
authors.initials: A
authors.lastname: Ward
authors.forename: Sidney
authors.initials: S
authors.lastname: Fels
authors.forename: Purang
authors.initials: P
authors.lastname: Abolmaesumi
mesh_terms: D001696:Biomechanical Phenomena; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015233:Models, Statistical; D011467:Prostate / Q000033:anatomy & histology / Q000000981:diagnostic imaging* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography