title: Formulation and evaluation of nanocrystalline cellulose as a potential disintegrant.
abstract: Disintegrant is a typical excipient that improves the solubility, dissolution and bioavailability of drug. In this study, the application of nanocrystalline cellulose (NCC) as a potential disintegrant in the preparation of tablet was investigated. Angle of repose of NCC was 44.26° which was between L-HPC and MCC suggesting a good fluidity of NCC. Swelling property of NCC was between CMS-Na and MCC indicating that NCC was of good absorbent ability. Carbonate calcium tablet of which NCC was used as a disintegrant exhibited fastest disintegration time than known disintegrants. The disintegration and dissolution tests demonstrated that NCC showed effective disintegrant properties, e.g. consistently fast disintegration, rapid dissolution, and effectiveness at low concentrations. Thus, we believe that NCC has a great potential as a disintegrant in tablets.
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Chengyu
authors.initials: C
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Huijin
authors.initials: H
authors.lastname: Huang
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Jin
authors.affiliation: Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing 100190, China. Electronic address: chart@nanoctr.cn.
authors.forename: Ruitao
authors.initials: R
authors.lastname: Cha
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D005079:Excipients; D013607:Tablets; D002482:Cellulose; D002119:Calcium Carbonate
keywords: Disintegrant; Disintegration time; Nanocrystalline cellulose