title: Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery.
abstract: OBJECTIVE
  To compare the postoperative analgesic efficacy and side effects of paracetamol and tramadol in patients undergoing lumbar disc surgery.
  
  
  METHODS
  Group P (paracetamol group) was given 1 g of paracetamol intravenously 30 min before the end of the operation and 1 g each day at 6-h intervals. Group T (tramadol group) was given 1.5 mg/kg of tramadol as a loading dose and patient-controlled analgesia for 1 day. Hemodynamic parameters, modified Aldrete score, Ramsay sedation scale score, patient satisfaction scale (PSS) score, visual analog scale (VAS) score, nausea/vomiting scale score, and additional analgesic needs/times were recorded.
  
  
  RESULTS
  PSS scores were significantly higher in Group T (P < 0.05). The total analgesic consumption was significantly higher in Group P. There were no significant differences in the VAS scores at any time points. Twenty-one patients in Group P and 8 patients in Group T needed additional analgesia (P < 0.05). The first additional analgesic time was earlier in Group P, and pain was more evident at the 15th minute and at hours 2 and 6 (P < 0.05).
  
  
  CONCLUSIONS
  Paracetamol alone was not able to provide effective analgesia. Tramadol was more effective in the treatment of postoperative pain after lumbar disc surgery.
authors.forename: Mehmet Ziya
authors.initials: MZ
authors.lastname: Yilmaz
authors.forename: Bahriye Binnur
authors.initials: BB
authors.lastname: Sarihasan
authors.forename: Ebru
authors.initials: E
authors.lastname: Kelsaka
authors.forename: Nilay
authors.initials: N
authors.lastname: Taş
authors.forename: Aysun
authors.initials: A
authors.lastname: Çaglar Torun
authors.forename: Ersin
authors.initials: E
authors.lastname: Köksal
authors.forename: Enis
authors.initials: E
authors.lastname: Kuruoğlu
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects* / Q000379:methods; D059408:Pain Management / Q000379:methods; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy; D013122:Spinal Diseases / Q000601:surgery*; D014147:Tramadol / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000082:Acetaminophen; D014147:Tramadol