title: Nicolaus Copernicus and the rapid vascular responses to aldosterone.
abstract: For decades, rapid steroid responses initiated by membrane receptors have been a primary research focus. G protein-coupled estrogen receptor (GPER) is activated by 17β-estradiol and participates in functional crosstalk with other steroid receptors. With reference to the physician and astronomer Nicolaus Copernicus (1473-1543), who used rigorous scientific approaches to shift paradigms and change dogma, we discuss whether GPER can also be considered an aldosterone receptor.
authors.affiliation: Molecular Internal Medicine, University of Zurich, Switzerland. Electronic address: barton@access.uzh.ch.
authors.forename: Matthias
authors.initials: M
authors.lastname: Barton
authors.affiliation: Department of Cardiology, Bern University Hospital, Switzerland.
authors.forename: Matthias R
authors.initials: MR
authors.lastname: Meyer
mesh_terms: D002621:Chemistry / Q000266:history; D005197:Famous Persons; D049668:History, 15th Century; D049669:History, 16th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D043562:Receptors, G-Protein-Coupled / Q000502:physiology*; D018161:Receptors, Mineralocorticoid / Q000502:physiology*; D012586:Science / Q000266:history
chemical_list: D043562:Receptors, G-Protein-Coupled; D018161:Receptors, Mineralocorticoid
keywords: GPR30; aldosterone; membrane receptor; non-genomic; steroid receptor