title: Metformin treatment before and during in vitro fertilization or intracytoplasmic sperm injection in women with polycystic ovary syndrome: summary of a Cochrane review.
abstract: In women with polycystic ovary syndrome, metformin treatment before or during assisted reproductive technology cycles increases clinical pregnancy rates and decreases the risk of ovarian hyperstimulation syndrome. However, there is no conclusive evidence of a benefit in live birth rates.
authors.affiliation: Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Leopoldo O
authors.initials: LO
authors.lastname: Tso
authors.affiliation: Division of Obstetrics & Gynaecology, School of Women's and Children's Health, University of New South Wales and Royal Hospital for Women and IVF Australia, Sydney, New South Wales, Australia.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Costello
authors.affiliation: Human Reproduction Center, Fertivitro Center for Human Reproduction Humana, São Paulo, Brazil.
authors.forename: Luiz Eduardo T
authors.initials: LE
authors.lastname: Albuquerque
authors.affiliation: Department of Public Health, University of Pará State, Belém, Brazil.
authors.forename: Régis B
authors.initials: RB
authors.lastname: Andriolo
authors.affiliation: Cochrane Office, University of Auckland, Auckland, New Zealand. Electronic address: j.marjoribanks@auckland.ac.nz.
authors.forename: Jane
authors.initials: J
authors.lastname: Marjoribanks
authors.affiliation: Brazilian Cochrane Centre, Centre for Evidence Based Health Studies and Health Technology Evaluation, São Paulo, Brazil.
authors.forename: Cristiane R
authors.initials: CR
authors.lastname: Macedo
mesh_terms: D016009:Chi-Square Distribution; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005307:Fertilization in Vitro; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects; D016017:Odds Ratio; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control; D010062:Ovulation Induction / Q000009:adverse effects; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D012307:Risk Factors; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin
keywords: Metformin; assisted reproductive techniques; intracytoplasmic sperm injection; in vitro fertilization; polycystic ovary syndrome