title: Imatinib mesylate treatment in a dog with gastrointestinal stromal tumors with a c-kit mutation.
abstract: A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months after surgical resection of the tumor, we detected the recurrence of GIST with multiple disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn(508)Ile), which has been shown to cause ligand-independent phosphorylation of the KIT protein in GISTs and canine mast cell tumors (MCTs). Upon detection of the recurrent tumors, we initiated treatment with imatinib mesylate (10 mg/kg, q 24 hr). After 2 months, the dog achieved complete remission. Our findings indicate that canine GIST, and possibly MCT, may be responsive to molecular-targeted therapy.
authors.affiliation: Shikoku Veterinary Medical Center, 3308-5 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0701, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Irie
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Ohtake
authors.forename: Hitomi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Nao
authors.initials: N
authors.lastname: Nagata
authors.forename: Takuma
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yamagami
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018076:DNA, Complementary; D004283:Dog Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D004285:Dogs; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D005786:Gene Expression Regulation; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D009154:Mutation; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D018076:DNA, Complementary; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit