title: [Research progress on hypoglycemic effect and its mechanism of action of medicinal fungal polysaccharides].
abstract: Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. Medicinal fungal polysaccharides, as water-soluble macromolecular substances with low toxicity, exhibit diversified pharmacological actions such as immune regulation, anti-tumor, antivirus, antioxidant, anti-aging, hypoglycemic effect and improving liver and kidney function. In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and β cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of α-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation. Therefore, the hypoglycemic activity and its mechanisms of action of medicinal fungal polysaccharides showed characteristics of multiple effects, multi-target, and multi-pathway regulation. These finding suggest that medicinal fungal polysaccharides are a promising source for the development of discovery of anti-diabetic agent.
authors.forename: Rong
authors.initials: R
authors.lastname: Dai
authors.forename: Ru-ming
authors.initials: RM
authors.lastname: Liu
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Xiao
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects; D062610:Fungal Polysaccharides / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D062610:Fungal Polysaccharides; D007004:Hypoglycemic Agents