title: Trichomonas vaginalis Cysteine Proteinases: Iron Response in Gene Expression and Proteolytic Activity.
abstract: We focus on the iron response of Trichomonas vaginalis to gene family products such as the cysteine proteinases (CPs) involved in virulence properties. In particular, we examined the effect of iron on the gene expression regulation and function of cathepsin L-like and asparaginyl endopeptidase-like CPs as virulence factors. We addressed some important aspects about CPs genomic organization and we offer possible explanations to the fact that only few members of this large gene family are expressed at the RNA and protein levels and the way to control their proteolytic activity. We also summarized all known iron regulations of CPs at transcriptional, posttranscriptional, and posttranslational levels along with new insights into the possible epigenetic and miRNA processes.
authors.affiliation: Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Rossana
authors.identifier: 0000-0002-8193-9700
authors.initials: R
authors.lastname: Arroyo
authors.affiliation: Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Rosa Elena
authors.initials: RE
authors.lastname: Cárdenas-Guerra
authors.affiliation: Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Elisa Elvira
authors.initials: EE
authors.lastname: Figueroa-Angulo
authors.affiliation: Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Puente-Rivera
authors.affiliation: Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Olga
authors.initials: O
authors.lastname: Zamudio-Prieto
authors.affiliation: Departamento de Biotecnología y Bioingeniería, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida IPN 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Jaime
authors.initials: J
authors.lastname: Ortega-López
mesh_terms: D000595:Amino Acid Sequence; D057056:Cysteine Proteases / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D007501:Iron / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics; D012313:RNA / Q000235:genetics; D014246:Trichomonas vaginalis / Q000201:enzymology* / Q000472:pathogenicity
chemical_list: D035683:MicroRNAs; D012313:RNA; D007501:Iron; D057056:Cysteine Proteases