title: From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome.
abstract: The development of in vitro fertilization (IVF) techniques for infertility management has led to the investigation of the proteome of follicular fluid and oocyte. In addition, different markers contributing to oocyte maturation and embryo development potential have been reported in the literature. Different techniques were utilized to analyze whole proteome or single protein markers in follicular fluid and oocytes, particularly in animal models. Data from several studies have generated large amounts of information, however, an ideal profile to predict the best oocytes and embryos suitable for implantation are still to be uncovered. The identification of such profiles and markers from follicular fluid, oocytes and endometrium should help scientists and clinicians develop better strategies to improving clinical outcome of IVF cycles.
authors.affiliation: Reproductive Biology and Medical Cytogenetics Laboratory, Regional University Hospital & School of Medicine, Picardie University Jules Verne, Amiens, France.
authors.forename: Moncef
authors.initials: M
authors.lastname: Benkhalifa
authors.forename: Aicha
authors.initials: A
authors.lastname: Madkour
authors.forename: Noureddine
authors.initials: N
authors.lastname: Louanjli
authors.forename: Nouzha
authors.initials: N
authors.lastname: Bouamoud
authors.forename: Brahim
authors.initials: B
authors.lastname: Saadani
authors.forename: Ismail
authors.initials: I
authors.lastname: Kaarouch
authors.forename: Hikmat
authors.initials: H
authors.lastname: Chahine
authors.forename: Omar
authors.initials: O
authors.lastname: Sefrioui
authors.forename: Philippe
authors.initials: P
authors.lastname: Merviel
authors.forename: Henri
authors.initials: H
authors.lastname: Copin
mesh_terms: D000818:Animals; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D009865:Oocytes / Q000378:metabolism*; D020543:Proteome
chemical_list: D020543:Proteome
keywords: embryo implantation; follicular fluid; oocyte proteome; oocytes quality