title: Neurofibromatosis: part 2--clinical management.
abstract: Part 1 of this guideline addressed the differential diagnosis of the neurofibromatoses (NF): neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH). NF shares some features such as the genetic origin of the neural tumors and cutaneous manifestations, and affects nearly 80 thousand Brazilians. Increasing scientific knowledge on NF has allowed better clinical management and reduced rate of complications and morbidity, resulting in higher quality of life for NF patients. Most medical doctors are able to perform NF diagnosis, but the wide range of clinical manifestations and the inability to predict the onset or severity of new features, consequences, or complications make NF management a real clinical challenge, requiring the support of different specialists for proper treatment and genetic counseling, especially in NF2 and SCH. The present text suggests guidelines for the clinical management of NF, with emphasis on NF1.
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Pollyanna Barros
authors.initials: PB
authors.lastname: Batista
authors.affiliation: Faculdade de Medicina de São José do Rio Preto, Sao Paulo, SP, Brazil.
authors.forename: Eny Maria Goloni
authors.initials: EM
authors.lastname: Bertollo
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Danielle de Souza
authors.initials: Dde S
authors.lastname: Costa
authors.affiliation: Radiologia Anchieta, Brasília, DF, Brazil.
authors.forename: Lucas
authors.initials: L
authors.lastname: Eliam
authors.affiliation: Faculdade de Medicina, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
authors.forename: Karin Soares Gonçalves
authors.initials: KS
authors.lastname: Cunha
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: José Renan
authors.initials: JR
authors.lastname: Cunha-Melo
authors.affiliation: Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, SP, Brazil.
authors.forename: Luiz Guilherme
authors.initials: LG
authors.lastname: Darrigo Junior
authors.affiliation: Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Mauro
authors.initials: M
authors.lastname: Geller
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Ingrid Faria
authors.initials: IF
authors.lastname: Gianordoli-Nascimento
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Luciana Gonçalves
authors.initials: LG
authors.lastname: Madeira
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Hérika Martins
authors.initials: HM
authors.lastname: Mendes
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Débora Marques de
authors.initials: DM
authors.lastname: Miranda
authors.affiliation: Loyola University of Chicago, USA.
authors.forename: Nikolas Andre
authors.initials: NA
authors.lastname: Mata-Machado
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Eric Grossi
authors.initials: EG
authors.lastname: Morato
authors.affiliation: Faculdade de Medicina de São José do Rio Preto, Sao Paulo, SP, Brazil.
authors.forename: Érika Cristina
authors.initials: ÉC
authors.lastname: Pavarino
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Luciana Baptista
authors.initials: LB
authors.lastname: Pereira
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Nilton Alves de
authors.initials: NA
authors.lastname: Rezende
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Luíza de Oliveira
authors.initials: Lde O
authors.lastname: Rodrigues
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Jorge Bezerra Cavalcanti
authors.initials: JB
authors.lastname: Sette
mesh_terms: D019468:Disease Management; D006801:Humans; D009442:Neurilemmoma / Q000150:complications / Q000473:pathology / Q000628:therapy*; D017253:Neurofibromatoses / Q000150:complications / Q000473:pathology / Q000628:therapy*; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology / Q000628:therapy*; D016518:Neurofibromatosis 2 / Q000150:complications / Q000473:pathology / Q000628:therapy*; D020339:Optic Nerve Glioma / Q000473:pathology / Q000628:therapy; D012307:Risk Factors; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*