title: Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis.
abstract: Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricular-subventricular zone (V-SVZ), replenish olfactory neurons throughout life. However, V-SVZ NSCs are heterogeneous: they have different embryonic origins and give rise to distinct neuronal subtypes depending on their location. In this Review, we discuss how this spatial heterogeneity arises, how it affects NSC biology, and why its consideration in future studies is crucial for understanding general principles guiding NSC self-renewal, differentiation and specification.
authors.affiliation: Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix AZ 85013, USA.
authors.forename: Roberto
authors.initials: R
authors.lastname: Fiorelli
authors.affiliation: Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Kasum
authors.initials: K
authors.lastname: Azim
authors.affiliation: Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
authors.forename: Bruno
authors.initials: B
authors.lastname: Fischer
authors.affiliation: Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland Inserm U846, Stem Cell and Brain Research Institute, 18 Avenue Doyen Lépine, Bron 69500, France Université de Lyon, Université Lyon 1, Bron 69500, France olivier.raineteau@inserm.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Raineteau
mesh_terms: D019521:Body Patterning / Q000502:physiology*; D006801:Humans; D020547:Lateral Ventricles / Q000254:growth & development*; D058953:Neural Stem Cells / Q000166:cytology*; D055495:Neurogenesis / Q000502:physiology*; D016548:Prosencephalon / Q000166:cytology / Q000254:growth & development*
keywords: Neurogenesis; Patterning; Specification; Subventricular zone; Transcription factors