title: Mast cell production and response to IL-4 and IL-13.
abstract: IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4Rα, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13.
authors.affiliation: Department of Biology, Virginia Commonwealth University Richmond, VA 23284, United States. Electronic address: mcleodjj@vcu.edu.
authors.forename: Jamie J A
authors.initials: JJ
authors.lastname: McLeod
authors.affiliation: Department of Biology, Virginia Commonwealth University Richmond, VA 23284, United States.
authors.forename: Bianca
authors.initials: B
authors.lastname: Baker
authors.affiliation: Department of Biology, Virginia Commonwealth University Richmond, VA 23284, United States.
authors.forename: John J
authors.initials: JJ
authors.lastname: Ryan
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000818:Animals; D001249:Asthma / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007107:Immune System; D007249:Inflammation / Q000276:immunology; D018793:Interleukin-13 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D008407:Mast Cells / Q000166:cytology*; D051379:Mice; D019948:Receptors, Interleukin-4 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000305:Adrenal Cortex Hormones; D016207:Cytokines; C578095:IL13 protein, human; C508598:IL4 protein, human; D018793:Interleukin-13; D019948:Receptors, Interleukin-4; D015847:Interleukin-4
keywords: IL-13; IL-4; Interleukin-13; Interleukin-4; Mast cells