title: Clonal diversity in glioblastoma: is it clinically relevant?
abstract: "Serial tumor sampling, single-cell genomics and quantitative imaging are all available technologies, but their integration into current pathways of care will require a paradigm shift in the clinical management of patients with glioblastoma."
authors.forename: Colin
authors.initials: C
authors.lastname: Watts
authors.forename: Sara G M
authors.initials: SG
authors.lastname: Piccirillo
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D006801:Humans; D058990:Molecular Targeted Therapy; D009154:Mutation; D015398:Signal Transduction
keywords: brain; cancer; cancer stem cells; clinical trials; evolution; genomics; glioblastoma; sampling bias; therapy