title: [Efficacy and mechanism of hemoperfusion plus hemodialysis for peripheral neuropathy of uremic patients on maintenance hemodialysis].
abstract: OBJECTIVE
  To explore the efficacy and mechanism of hemoperfusion (HP) plus hemodialysis (HD) for peripheral neuropathy of uremic patients on maintenance hemodialysis.
  
  
  METHODS
  A total of 66 uremic patients on hemodialysis during January 2014 and April 2011 were assigned randomly into HP+HD, low-flux HD and high-flux HD groups (n=22 each). The serum levels of leptin, endothelin-1 (ET-1), parathyroid hormone (PTH) and β-2 microglobulin were observed pre and post-treatment. And sensory conduction velocity (SCV) was detected simultaneously.
  
  
  RESULTS
  After 12-week treatment, the clinical symptoms of group HP+HD improved significantly with an effective rate of 90.91% while improvement was not obvious in groups high-flux and low-flux HD with effective rates of 31.82% and 13.64%. In HP+HD group, the levels of leptin, ET-1, PTH and β-2MG decreased, sensory conduction velocity increased (P<0.05) and clinical symptoms improved apparently. While in low-flux HD and high-flux HD groups, leptin, ET-1, PTH and β-2MG had no decrease and SCV showed no improvement (P>0.05). Correlation analysis showed that the levels of leptin, ET-1 and β-2MG were negatively correlated with SCV (r=-0.57, r=-0.47, r=-0.56). Yet PTH had no correlation with SCV (r=-0.23).
  
  
  CONCLUSIONS
  Hemoperfusion plus hemodialysis may improve the clinical symptoms of peripheral neuropathy of uremic patients on maintenance hemodialysis. And it is probably due to the fact that HP+HD effectively removes such plasma middle and macromolecular toxins as leptin, ET-1, PTH and β-2MG.
authors.affiliation: Blood Purification Center, Municipal People's Hospital, Zhengzhou 450003, China; Email: wendyshy@126.com.
authors.forename: Wenli
authors.initials: W
authors.lastname: Cai
authors.affiliation: Blood Purification Center, Municipal People's Hospital, Zhengzhou 450003, China.
authors.forename: Shuzhai
authors.initials: S
authors.lastname: Miao
authors.affiliation: Blood Purification Center, Municipal People's Hospital, Zhengzhou 450003, China.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Blood Purification Center, Municipal People's Hospital, Zhengzhou 450003, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xing
mesh_terms: D019332:Endothelin-1; D006464:Hemoperfusion; D006801:Humans; D020738:Leptin; D010281:Parathyroid Hormone; D010523:Peripheral Nervous System Diseases; D006435:Renal Dialysis; D001613:beta 2-Microglobulin
chemical_list: D019332:Endothelin-1; D020738:Leptin; D010281:Parathyroid Hormone; D001613:beta 2-Microglobulin