title: Disseminated Infections with Talaromyces marneffei in Non-AIDS Patients Given Monoclonal Antibodies against CD20 and Kinase Inhibitors.
abstract: Infections with the fungus Talaromyces (formerly Penicillium) marneffei are rare in patients who do not have AIDS. We report disseminated T. marneffei infection in 4 hematology patients without AIDS who received targeted therapy with monoclonal antibodies against CD20 or kinase inhibitors during the past 2 years. Clinicians should be aware of this emerging complication, especially in patients from disease-endemic regions.
authors.forename: Jasper F W
authors.initials: JF
authors.lastname: Chan
authors.forename: Thomas S Y
authors.initials: TS
authors.lastname: Chan
authors.forename: Harinder
authors.initials: H
authors.lastname: Gill
authors.forename: Frank Y F
authors.initials: FY
authors.lastname: Lam
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Trendell-Smith
authors.forename: Siddharth
authors.initials: S
authors.lastname: Sridhar
authors.forename: Herman
authors.initials: H
authors.lastname: Tse
authors.forename: Susanna K P
authors.initials: SK
authors.lastname: Lau
authors.forename: Ivan F N
authors.initials: IF
authors.lastname: Hung
authors.forename: Kwok-Yung
authors.initials: KY
authors.lastname: Yuen
authors.forename: Patrick C Y
authors.initials: PC
authors.lastname: Woo
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D009570:Nitriles; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011720:Pyrazoles / Q000009:adverse effects / Q000627:therapeutic use; D011743:Pyrimidines; D000069283:Rituximab / Q000627:therapeutic use; D032901:Talaromyces; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009570:Nitriles; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011743:Pyrimidines; D000069283:Rituximab; C540383:ruxolitinib
keywords: CD20; Talaromyces (Penicillium) marneffei; fungi; kinase inhibitors; monoclonal antibodies; obinutuzumab; rituximab; ruxolitinib; sorafenib