title: Cross-Presentation in Mouse and Human Dendritic Cells.
abstract: Cross-presentation designates the presentation of exogenous antigens on major histocompatibility complex class I molecules and is essential for the initiation of cytotoxic immune responses. It is now well established that dendritic cells (DCs) are the best cross-presenting cells. In this chapter, we will discuss recent advances in our understanding of the molecular mechanisms of cross-presentation. We will also describe the different DC subsets identified in mouse and human, and their functional specialization for cross-presentation. Finally, we will summarize the current knowledge of the role of cross-presentation in pathological situations.
authors.affiliation: Institut Curie, Paris Cedex 05, France; INSERM U932, Paris Cedex 05, France. Electronic address: elodie.segura@curie.fr.
authors.forename: Elodie
authors.initials: E
authors.lastname: Segura
authors.affiliation: Institut Curie, Paris Cedex 05, France; INSERM U932, Paris Cedex 05, France.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Amigorena
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015551:Autoimmunity; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D004705:Endocytosis; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: Cross-presentation; DC subsets; Dendritic cells; Human; Phagosome