title: Anti-Phosphatidylserine/Prothrombin Antibodies Are Associated with Adverse Pregnancy Outcomes.
abstract: Objective. To determine the prevalence and clinical association of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in patients with a history of pregnancy complications relevant to antiphospholipid syndrome (APS). Materials and Methods. Two hundred and eleven patients with a history of (a) three or more consecutive miscarriages before 10th week of gestation (WG) (n = 64), (b) death of a morphologically normal fetus beyond 10th WG (n = 72), (c) premature birth of a morphologically normal neonate before 34th WG due to eclampsia, preeclamsia and placental insufficiency (n = 33), and (d) less than three unexplained consecutive miscarriages before 10th WG (n = 42). Subjects sera were analyzed for lupus anticoagulant (LA), anti-cardiolipin (aCL), anti-β 2-glycoprotein I (anti-β 2GPI), and aPS/PT antibodies. Results. 41/169 (24.3%) of patients were positive for at least one measured aPL. The highest prevalence was found for aPS/PT and aCL (13.0% and 12.4%, resp.) followed by LA (7.7%) and anti-β 2GPI (7.1%). 11/169 with APS-related obstetric manifestations had only aPS/PT. 17.8% of patients were positive for LA or aCL and/or anti-β 2GPI; however when adding the aPS/PT results, an additional 7% of patients could be evaluated for APS. Conclusion. aPS/PT are associated with recurrent early or late abortions and with premature delivery irrespective of other aPL.
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Polona
authors.initials: P
authors.lastname: Žigon
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Katja
authors.identifier: 0000-0001-7778-4016
authors.initials: K
authors.lastname: Perdan Pirkmajer
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Matija
authors.initials: M
authors.lastname: Tomšič
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Kveder
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia ; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, SI-1000 Ljubljana, Slovenia.
authors.forename: Borut
authors.initials: B
authors.lastname: Božič
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia ; Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, SI-6000 Koper, Slovenia.
authors.forename: Snežna
authors.initials: S
authors.lastname: Sodin Šemrl
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Saša
authors.initials: S
authors.lastname: Čučnik
authors.affiliation: Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova 62, SI-1000 Ljubljana, Slovenia.
authors.forename: Aleš
authors.initials: A
authors.lastname: Ambrožič
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D010718:Phosphatidylserines / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D011256:Pregnancy Outcome; D015995:Prevalence; D011516:Prothrombin / Q000276:immunology*; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010718:Phosphatidylserines; D053482:beta 2-Glycoprotein I; D011516:Prothrombin