title: The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma.
abstract: The melanoma-associated antigens Melan-A and NY-ESO-1 stimulate different T-cell responses in late-stage melanoma patients. Either CD4+or CD8+T-cell reactivity against NY-ESO-1 was associated with better prognosis, but for Melan-A, only CD8+but not CD4+T-cell responses were associated with longer survival.
authors.affiliation: Interfaculty Institute for Cell Biology; Department of Immunology; University of Tübingen ; Tübingen, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Zelba
authors.affiliation: Division of Dermatooncology; Department of Dermatology; Tübingen University Medical Center ; Tübingen, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Weide
authors.affiliation: Department of Internal Medicine II; Section for Transplantation Immunology and Immunohematology; Tübingen University Medical Center ; Tübingen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Martens
authors.affiliation: Department of Internal Medicine II; Section for Transplantation Immunology and Immunohematology; Tübingen University Medical Center ; Tübingen, Germany.
authors.forename: Jithendra Kini
authors.initials: JK
authors.lastname: Bailur
authors.affiliation: Division of Dermatooncology; Department of Dermatology; Tübingen University Medical Center ; Tübingen, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Garbe
authors.affiliation: Department of Internal Medicine II; Section for Transplantation Immunology and Immunohematology; Tübingen University Medical Center ; Tübingen, Germany.
authors.forename: Graham
authors.initials: G
authors.lastname: Pawelec
keywords: MAGE-A3; Melan-A; NY-ESO-1; antigen-specific T-cells; intracellular cytokine staining; survivin