title: CCR 20th Anniversary Commentary: From Regulatory T Cells to Checkpoint Monoclonal Antibodies--Immuno-oncology Advances Clinical Cancer Research.
abstract: Immune escape is a hallmark of cancer development and metastasis. Regulatory T cells (Treg) are potent inhibitors of cancer immune surveillance but also prevent inflammation-driven tumorigenesis. The study by Wolf and colleagues, which was published in the February 2003 issue of Clinical Cancer Research, showed the expansion of Treg in solid cancer patients, providing a deeper understanding of cancer immune escape mechanisms that later set the stage for the development of scientific breakthroughs in cancer immunotherapy.
authors.affiliation: Medical Clinic III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn (UKB), Bonn, Germany. Laboratory of Tumor Immunology, Department of Medicine V, Medical University Innsbruck, Innsbruck, Austria. dominik.wolf@ukb.uni-bonn.de anna_maria.wolf@ukb.uni-bonn.de.
authors.forename: Dominik
authors.initials: D
authors.lastname: Wolf
authors.affiliation: Medical Clinic III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn (UKB), Bonn, Germany. Laboratory of Tumor Immunology, Department of Medicine V, Medical University Innsbruck, Innsbruck, Austria. dominik.wolf@ukb.uni-bonn.de anna_maria.wolf@ukb.uni-bonn.de.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Wolf
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics*; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor; D051858:Forkhead Transcription Factors