title: Plasma lactate concentrations and comparison of two point-of-care lactate analyzers to a laboratory analyzer in a population of healthy cats.
abstract: OBJECTIVE
  To establish a reference interval for plasma lactate in a population of healthy adult cats on a laboratory analyzer (Nova Biomedical Critical Care Xpress [CCX]) and 2 commercially available point-of-care (POC) analyzers (Abbott i-STAT [i-STAT] and Nova Biomedical Lactate Plus [LP]), and to compare the level of agreement of lactate measurement between the laboratory analyzer and POC analyzers.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  University veterinary teaching hospital.
  
  
  METHODS
  Forty-seven healthy adult cats.
  
  
  METHODS
  Jugular phlebotomy.
  
  
  RESULTS
  In this population, plasma lactate reference interval was 0.67-5.44 mmol/L for the CCX, 0.65-5.16 mmol/L for the i-STAT, and 0.68-4.39 mmol/L for the LP. Comparisons were made between lactate measurements on 2 point-of-care analyzers and the laboratory analyzer using the Bland-Altman method. For the comparison of CCX and i-STAT, the bias was -0.10 mmol/L; for the CCX and LP, the bias was -0.24 mmol/L.
  
  
  CONCLUSIONS
  Measurements of plasma lactate in cats using the i-STAT showed acceptable agreement with the CCX. The LP showed weaker agreement. However, both POC analyzers are suitable for measurement of lactate in cats, provided results from different POC analyzers are not directly compared. This study identified a larger reference interval for plasma lactate concentration in cats than what has been previously reported.
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO, 65211.
authors.forename: Beth
authors.initials: B
authors.lastname: Tynan
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO, 65211.
authors.forename: Marie E
authors.initials: ME
authors.lastname: Kerl
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO, 65211.
authors.forename: Mary L
authors.initials: ML
authors.lastname: Jackson
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri College of Veterinary Medicine, 900 East Campus Drive, Columbia, MO, 65211.
authors.forename: F A
authors.initials: FA
authors.lastname: Mann
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000662:veterinary*; D002415:Cats / Q000097:blood*; D005260:Female; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D019095:Point-of-Care Systems; D011446:Prospective Studies; D012015:Reference Standards
chemical_list: D019344:Lactic Acid
keywords: acidemia; point-of-care; shock