title: [Expressions of TUBB3 and γ-synuclein in colorectal adenocarcinoma and their clinical significance].
abstract: OBJECTIVE
  To explore the expressions of TUBB3 (β-tubulin III) and γ-synuclein (SNCG) in colorectal adenocarcinoma and their clinical significance.
  
  
  METHODS
  The expressions of TUBB3 and γ-synuclein were detected by SP immunohistochemistry in 180 cases of colorectal adenocarcinoma.
  
  
  RESULTS
  TUBB3 protein positive rate was 82.2% and γ-synuclein protein positive rate 73.9% in colorectal adenocarcinoma. And there were insignificant differences of positive expression between TUBB3 and γ-synuclein (P > 0.05). The positive expression of TUBB3 was not correlated with gender, age, histological differentiation, depth of tumor invasion or clinical stage (P > 0.05). The positive expression of γ-synuclein was closely correlated with depth of tumor invasion and clinical stage (P < 0.05), but with gender, age or histological differentiation (P > 0.05). The positive expressions of TUBB3 and γ-synuclein were correlated in colorectal adenocarcinoma (r = 0.154, P < 0.05).
  
  
  CONCLUSIONS
  γ-synuclein, detected by immunohistochemistry is better than TUBB3 in colorectal adenocarcinoma. And γ-synuclein may be used as a new prognostic biomarker and therapeutic target.
authors.affiliation: Department of Pathology, Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin 300162, China.
authors.forename: Heyang
authors.initials: H
authors.lastname: Sun
authors.forename: Lifang
authors.initials: L
authors.lastname: Shi
authors.forename: Xuan
authors.initials: X
authors.lastname: He
authors.affiliation: Email: zhengshf@126.com.
authors.forename: Shufang
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000230:Adenocarcinoma; D015179:Colorectal Neoplasms; D006801:Humans; D007150:Immunohistochemistry; D014404:Tubulin; D051845:gamma-Synuclein
chemical_list: C498585:TUBB3 protein, human; D014404:Tubulin; D051845:gamma-Synuclein