title: Lessons from Nature: A Bio-Inspired Approach to Molecular Design.
abstract: Metalloproteins contain actives sites with intricate structures that perform specific functions with high selectivity and efficiency. The complexity of these systems complicates the study of their function and the understanding of the properties that give rise to their reactivity. One approach that has contributed to the current level of understanding of their biological function is the study of synthetic constructs that mimic one or more aspects of the native metalloproteins. These systems allow individual contributions to the structure and function to be analyzed and also permit spectroscopic characterization of the metal cofactors without complications from the protein environment. This Current Topic is a review of synthetic constructs as probes for understanding the biological activation of small molecules. These topics are developed from the perspective of seminal molecular design breakthroughs from the past that provide the foundation for the systems used today.
authors.affiliation: Department of Chemistry, University of California-Irvine, 1102 Natural Sciences II, Irvine, California 92697, United States.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Cook
authors.affiliation: Department of Chemistry, University of California-Irvine, 1102 Natural Sciences II, Irvine, California 92697, United States.
authors.forename: Ethan A
authors.initials: EA
authors.lastname: Hill
authors.affiliation: Department of Chemistry, University of California-Irvine, 1102 Natural Sciences II, Irvine, California 92697, United States.
authors.forename: A S
authors.initials: AS
authors.lastname: Borovik
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D010100:Oxygen / Q000378:metabolism; D045332:Photosystem II Protein Complex / Q000737:chemistry / Q000378:metabolism; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism; D058615:Synthetic Biology
chemical_list: D006454:Hemoglobins; D008667:Metalloproteins; D045332:Photosystem II Protein Complex; D011166:Porphyrins; D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen