title: An insight into functionalized calcium based inorganic nanomaterials in biomedicine: Trends and transitions.
abstract: Over the recent years the use of biocompatible and biodegradable nanoparticles in biomedicine has become a significant priority. Calcium based ceramic nanoparticles like calcium phosphate (CaP) and calcium carbonate (CaCO3) are therefore considered as attractive carriers as they are naturally present in human body with nanosize range. Their application in tissue engineering and localized controlled delivery of bioactives for bones and teeth is well established now, but recently their use has increased significantly as carrier of bioactives through other routes also. These delivery systems have become most potential alternatives to other commonly used delivery system because of their cost effectiveness, biodegradability, chemical stability, controlled and stimuli responsive behaviour. This review comprehensively covers their characteristic features, method of preparation and applications but the thrust is to focus their recent development, functionalization and use in systemic delivery. On the same platform mineralization of other nanoparticulate delivery system which has widened their application drug delivery will be discussed. The emphasis has been given on their pH dependent properties which make them excellent carriers for tumour targeting and intracellular delivery. Finally this review also attempts to discuss their drawback which limits their clinical utility.
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: Shweta
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: Ashwni
authors.initials: A
authors.lastname: Verma
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: B Venkatesh
authors.initials: BV
authors.lastname: Teja
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: Gitu
authors.initials: G
authors.lastname: Pandey
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: Naresh
authors.initials: N
authors.lastname: Mittapelly
authors.affiliation: Division of Endocrinology, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Trivedi
authors.affiliation: Division of Pharmaceutics, CSIR-Central Drug Research Institute, B 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India. Electronic address: prabhat_mishra@cdri.res.in.
authors.forename: P R
authors.initials: PR
authors.lastname: Mishra
mesh_terms: D002118:Calcium / Q000378:metabolism*; D049329:Nanostructures
chemical_list: D002118:Calcium
keywords: Endosome disruption; Mineralization; Tissue engineering; pH dependant solubility; siRNA delivery