title: Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children.
abstract: Investigate associations of TV viewing time and accelerometry-derived sedentary time with inflammatory and endothelial function biomarkers in children.
  
  
  
  Cross-sectional analysis of 164 7-10-year-old children. TV viewing time was assessed by parental proxy report and total and patterns of sedentary time accumulation (e.g. prolonged bouts) were assessed by accelerometry. C-reactive protein (CRP), homeostasis model assessment of insulin resistance, interleukin-2, -6, -8, -10, tumour necrosis factor alpha, adiponectin, resistin, brain-derived neurotrophic factor, soluble intercellular and vascular adhesion molecule 1, plasminogen activator inhibitor 1 and soluble E-selectin were assessed. Generalised linear models assessed the associations of TV viewing and sedentary time with biomarkers, adjusting for sex, waist circumference, moderate- to vigorous-intensity physical activity and diet density.
  
  
  
  Each additional h week(-1) of TV viewing was associated with 4.4% (95% CI: 2.1, 6.7) greater CRP and 0.6% (0.2, 1.0) greater sVCAM-1 in the fully adjusted model. The association between frequency and duration of 5-10 min bouts of sedentary time and CRP was positive after adjustment for sex and waist circumference but attenuated after adjustment for diet density.
  
  
  
  This study suggests that TV viewing was unfavourably associated with several markers of inflammation and endothelial dysfunction. The detrimental association between 5 and 10 min bouts of sedentary time and CRP approached significance, suggesting that further research with a stronger study design (longitudinal and/or experimental) is needed to better understand how the accumulation of sedentary time early in life may influence short and longer term health.
authors.affiliation: Experimental Medicine Program, Faculty of Medicine & Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.|Centre for Hip Health and Mobility, Vancouver Coastal Research Institute, Vancouver, British Columbia, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Gabel
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: N D
authors.initials: ND
authors.lastname: Ridgers
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: P A
authors.initials: PA
authors.lastname: Della Gatta
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Arundell
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: E
authors.initials: E
authors.lastname: Cerin
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Robinson
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: Daly
authors.affiliation: Physical Activity and Behavioural Epidemiology Laboratories, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.|School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia.|School of Population Health, The University of Queensland, Brisbane, Queensland, Australia.|Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.|School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia, Australia.|Central Clinical School, Monash University, Melbourne, Victoria, Australia.
authors.forename: D W
authors.initials: DW
authors.lastname: Dunstan
authors.affiliation: Center for Physical Activity and Nutrition Research, Deakin University, Burwood, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Salmon
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular; D005260:Female; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D008297:Male; D057185:Sedentary Behavior; D012737:Sex Factors; D013690:Television; D013997:Time Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D019010:Vascular Cell Adhesion Molecule-1; D002097:C-Reactive Protein
keywords: Cardiometabolic; paediatric; sedentary behaviour