title: The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) are the new markers of the detection of inflammation. Our aim is to investigate MPV and NLR in lean and obese patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This study was designed to investigate MPV, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 25 obese patients with PCOS and 16 lean patients with PCOS, and our study group was matched with 16 obese and 14 non-obese controls, respectively.
  
  
  RESULTS
  PCOS group had higher MPV, NLR, neutrophil count, neutrophil to total leucocyte ratio, basophil count, waist circumference (WC), insulin, glucose, and HOMA-IR rates than those of controls. hsCRP levels were similar in both groups. Subgroup analyses revealed that obese PCOS group had higher insulin and HOMA-IR levels, compared to those of controls. In this subgroup, total leucocyte counts, MPV, and hsCRP levels were similar. On the other hand, lean PCOS group had higher WC, NLR, MPV, and basophil count than controls. In correlation analysis, hsCRP was positively correlated with body mass index (BMI), WC, total leucocyte count, neutrophil count, while negatively correlated with lymphocyte ratio. Although leucocyte count was positively correlated with BMI, MPV was negatively correlated with BMI, total leucocyte, platelet, and neutrophil counts. NLR was positively correlated with HOMA-IR, hsCRP, BMI, WC, and insulin.
  
  
  CONCLUSIONS
  Our study demonstrated that MPV and NLR levels are increased despite similar hsCRP levels in patients with PCOS. However, we failed to demonstrate these differences in obese PCOS patients. Further studies with larger sample size are required to determine the significance of BMI in the inflammation of PCOS patients.
authors.affiliation: Department of Internal Medicine, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: M A
authors.initials: MA
authors.lastname: Yilmaz
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Clinic of Endocrinology and Metabolism, Konya Training and Research Hospital, 42100, Konya, Turkey. drcduran@gmail.com.
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.affiliation: Department of Obstetrics and Gynecology, Konya Training and Research Hospital, Konya, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Basaran
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000473:pathology*; D063847:Mean Platelet Volume / Q000706:statistics & numerical data; D009504:Neutrophils / Q000473:pathology*; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D013851:Thinness / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D002097:C-Reactive Protein
keywords: High-sensitive CRP; Mean platelet volume; Neutrophil to lymphocyte ratio; Polycystic ovary syndrome