title: Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis.
abstract: BACKGROUND
  The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA).
  
  
  METHODS
  We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system. Serum IL-17 levels were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Synovia IL-17 levels were significantly higher in OA patients compared with controls (P<0.01), and were negatively correlated with OA severity. IL-17 level gradually decreased among different phases but lacked statistical significance.
  
  
  CONCLUSIONS
  IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain. Blocking the IL-17 signaling pathway may delay pain related to OA.
authors.affiliation: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland).
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Orthopedics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Zhao
authors.initials: Z
authors.lastname: Meng
authors.affiliation: Department of Orthopedics, Shiyan Hospital of Integrated Traditional and Western Medicine, Shiyan, Hubei, China (mainland).
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Wei
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000378:metabolism*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020381:Interleukin-17