title: Does platelet-rich plasma enhance healing in the idiopathic bone cavity? A single-blind randomized clinical trial.
abstract: The presence of an idiopathic bone cavity (IBC) is usually identified during routine dental radiographic examinations. The purpose of this study was to investigate the effect of platelet-rich plasma (PRP) on bone healing in the idiopathic bone cavity. This was a single-blind randomized clinical trial. Twenty-four subjects were assigned randomly to two groups. Subjects in group 1 received PRP through a buccal window approach, and those in group 2 underwent conventional management via the creation of a window on the buccal wall and curettage of the walls of the defect. Subjects were followed up at 3, 6, and 9 months after the intervention. The amount of bone formation as determined on panoramic radiographs was divided into four categories: stage 1: ≤25% of the defect showed opacity; stage 2: 25-50% of the defect showed opacity; stage 3: 50-75% of the defect showed opacity; and stage 4: >75% of the defect showed opacity. There was a significant difference between the two groups with regard to the various healing stages at the three time points (P<0.05). When compared with conventional management of the idiopathic bone cavity, the use of PRP may enhance bone formation.
authors.affiliation: School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: Tabmed@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Tabrizi
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: T
authors.initials: T
authors.lastname: Karagah
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Shahidi
authors.affiliation: Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Zare
mesh_terms: D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001861:Bone Regeneration / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D011862:Radiography, Panoramic; D016037:Single-Blind Method; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D055815:Young Adult
keywords: bone; healing; idiopathic bone cavity; platelet-rich plasma