title: The expanding family of regulatory B cells.
abstract: Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (Bregs), contributes to the maintenance of tolerance, primarily via the production of IL-10. Studies in experimental animal models, as well as in patients with autoimmune diseases, have identified multiple Breg subsets exhibiting diverse mechanisms of immune suppression. In this review, we describe the different Breg subsets identified in mice and humans, and their diverse mechanisms of suppression in different disease settings.
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK c.mauri@ucl.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mauri
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK.
authors.forename: Madhvi
authors.initials: M
authors.lastname: Menon
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D060151:B-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication; D019070:Cell Lineage / Q000276:immunology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D056724:Immunity, Humoral; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology
chemical_list: D015703:Antigens, CD; C508609:IL10 protein, human; D016753:Interleukin-10
keywords: B cell; Bregs; IL-10; human; immune-suppression; mouse; regulation; regulatory B cells; subsets