title: Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.
abstract: The critical importance of membrane-bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.
authors.affiliation: Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: K L R
authors.initials: KL
authors.lastname: Brouwer
authors.affiliation: Department of Pharmacology and Toxicology, Rutgers, the State University of New Jersey, Ernest Mario School of Pharmacy, Piscataway, New Jersey, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Aleksunes
authors.affiliation: NIH Library, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: B
authors.initials: B
authors.lastname: Brandys
authors.affiliation: Obstetric and Pediatric Pharmacology and Therapeutics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Giacoia
authors.affiliation: College of Pharmacy, Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA.
authors.forename: G
authors.initials: G
authors.lastname: Knipp
authors.affiliation: Simulations Plus, lnc., Lancaster, California, USA.
authors.forename: V
authors.initials: V
authors.lastname: Lukacova
authors.affiliation: University of Tennessee Health Science Center, College of Pharmacy, Memphis, Tennessee, USA.
authors.forename: B
authors.initials: B
authors.lastname: Meibohm
authors.affiliation: University of California San Diego, La Jolla, California, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Nigam
authors.affiliation: Department of Pediatrics, University of Western Ontario, London, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Rieder
authors.affiliation: Erasmus MC Sophia Children's Hospital, Intensive Care and Department of Pediatric Surgery, Rotterdam, the Netherlands.
authors.forename: S N
authors.initials: SN
authors.lastname: de Wildt
mesh_terms: D000367:Age Factors; D000818:Animals; D001692:Biological Transport; D035843:Biomedical Research / Q000379:methods; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D026901:Membrane Transport Proteins / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics
chemical_list: D026901:Membrane Transport Proteins; D004364:Pharmaceutical Preparations