title: Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse.
abstract: The idea of multiple differentiation capacity of glioma stem cells and progentior cells (GSCPs) has been accepted by most of the researchers, but the effect of local environment on the differentiation of GSCPs is unclear. GSCPs SU2 and CM-Dil-stained C6 cells (C6-Dil) were injected into the brain of GFP transgenic nude mice. The xenografts were sectioned. Morphological changes of tumor cells that resided in the choroid plexus, molecular markers expression, and the relationship between the original tumor cells and host cells were studied carefully. The tumorigenicity rate was 40/40 (100%) in all of the inoculated nude mice. Cell morphology and molecular expression of neoplasm settled in the choroid plexus showed that choroidcarcinoma derived from GSCPs was developed. These results showed that GSCPs may have the multiple differentiation capacity, which can be induced by the local environment of host brain as NSCs, and cell fusion may play an important role in the transformation.
authors.affiliation: 1 Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine , Suzhou, China .
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1 Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine , Suzhou, China .
authors.forename: Xifeng
authors.initials: X
authors.lastname: Fei
authors.affiliation: 2 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University , Suzhou, China .
authors.forename: Xinliang
authors.initials: X
authors.lastname: Dai
authors.affiliation: 1 Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine , Suzhou, China .
authors.forename: Hanchun
authors.initials: H
authors.lastname: Chen
authors.affiliation: 3 Department of Pharmaceutical Preparation Section, Kowloon Hospital, Shanghai Jiaotong University School of Medicine , Suzhou, China .
authors.forename: Haiyan
authors.initials: H
authors.lastname: Tian
authors.affiliation: 2 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University , Suzhou, China .
authors.forename: Aidong
authors.initials: A
authors.lastname: Wang
authors.affiliation: 2 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University , Suzhou, China .
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.affiliation: 1 Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine , Suzhou, China .|2 Department of Neurosurgery, The Second Affiliated Hospital of Soochow University , Suzhou, China .
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology*; D002454:Cell Differentiation; D002465:Cell Movement; D002831:Choroid Plexus; D016545:Choroid Plexus Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000473:pathology*; D049452:Green Fluorescent Proteins / Q000235:genetics; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008819:Mice, Nude; D008822:Mice, Transgenic; D014411:Neoplastic Stem Cells / Q000502:physiology* / Q000637:transplantation; D064231:Nestin / Q000032:analysis; D059016:Tumor Microenvironment
chemical_list: D019394:Ki-67 Antigen; D064231:Nestin; D049452:Green Fluorescent Proteins
keywords: choroid plexus tumor; glioma stem cells and progenitor cells; mimicry differentiation; transplantation tumor; tumor microecosystem