title: Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging.
abstract: BACKGROUND
  There is a limited data on the association between serum uric acid (SUA) and cardiovascular disease (CVD) among the very elderly population.
  
  
  OBJECTIVE
  We evaluated the association of SUA, highly sensitive C-reactive protein (hs-CRP, a marker of vascular and systemic inflammation), and coronary artery calcification (CAC, a marker of subclinical CVD) in a cohort of Brazilian octogenarians (≥80 years) free from known clinical CVD.
  
  
  METHODS
  208 individuals were included and evaluated for an association between increasing tertiles of SUA, elevated hs-CRP (>3 mg/dL), the presence and burden of CAC (CAC > 0 and CAC > 400).
  
  
  RESULTS
  The median hs-CRP was 1.9 (IQR = 1.0-3.4) mg/L and mean SUA was 5.3 (±1.4) mg/dL. The overall prevalence of elevated hs-CRP (>3 mg/dL) was 31 %. A significant increase in the prevalence of hs-CRP was noted across the higher SUA tertiles (p < 0.001) with 3.4 times the odds of having elevated hs-CRP in the highest SUA tertile (3.40; CI = 1.27-9.08). No association was noted with either the CAC presence and/or CAC burden (CAC > 0 or CAC > 400) across the increasing SUA tertiles.
  
  
  CONCLUSIONS
  In the healthy octogenarians, higher SUA levels are associated with vascular inflammation (hs-CRP) but not with coronary atherosclerosis (CAC); markers for the subclinical CVD.
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Rehan
authors.initials: R
authors.lastname: Malik
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Ehimen C
authors.initials: EC
authors.lastname: Aneni
authors.affiliation: Aventura Hospital & Medical Center, Miami, FL, USA.
authors.forename: Sameer
authors.initials: S
authors.lastname: Shahrayar
authors.affiliation: Cardiology Department, State University of Campinas School of Medicine, Campinas, 13084-971, Sao Paulo, Brazil.
authors.forename: Wladimir M
authors.initials: WM
authors.lastname: Freitas
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.|University of Manchester School of Medicine, Manchester, UK.
authors.forename: Shozab S
authors.initials: SS
authors.lastname: Ali
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.|Robert Stempel College of Public Health, Florida International University, Miami, FL, USA.
authors.forename: Emir
authors.initials: E
authors.lastname: Veledar
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Latif
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Aziz
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Rameez
authors.initials: R
authors.lastname: Ahmed
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Sher A
authors.initials: SA
authors.lastname: Khan
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA.
authors.forename: Jeffrin
authors.initials: J
authors.lastname: Joseph
authors.affiliation: Aventura Hospital & Medical Center, Miami, FL, USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Feiz
authors.affiliation: Cardiology Department, State University of Campinas School of Medicine, Campinas, 13084-971, Sao Paulo, Brazil.
authors.forename: Andrei
authors.initials: A
authors.lastname: Sposito
authors.affiliation: Center for Prevention and Wellness Research, Baptist Health South Florida, 1691 Michigan Avenue Suite 500; Miami Beach, Miami, FL, 33139, USA. KhurramN@baptisthealth.net.|Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. KhurramN@baptisthealth.net.|Robert Stempel College of Public Health, Florida International University, Miami, FL, USA. KhurramN@baptisthealth.net.|Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. KhurramN@baptisthealth.net.
authors.forename: Khurram
authors.initials: K
authors.lastname: Nasir
mesh_terms: D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*; D061205:Vascular Calcification / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: CAC; Octogenarians; Subclinical CVD; hs-CRP and Serum Uric Acid