title: Dual-Wavelength Irradiation and Dox Delivery for -Cancer Cell Ablation with Photocatalytic Pr Doped TiO2 /NGO -Hybrid Nanocomposite.
abstract: Herein, hybrid nanocomposite of praseodymium doped TiO2 nanocrystals and graphene oxide nanosheets are prepared by facile hydrothermal treatment. As-synthesized Pr-TiO2 /NGO hybrid nanocomposite exhibits enhanced photocatalytic activity under visible light irradiation by the intact graphene oxide and doped lanthanide mediated band gap narrowing compared to TiO2 . Moreover, high payload and controlled release of doxorubicin by charge reversal of hybrid nanocomposite at endosomal pH and near-infrared irradiation mediated efficient photothermal conversion provide highly favorable features in therapeutic applications. Through the combination of these three distinctive therapeutic modalities, highly efficient trimodal cancer cell ablation is demonstrated.
authors.affiliation: Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.
authors.forename: Hongje
authors.initials: H
authors.lastname: Jang
authors.affiliation: Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.
authors.forename: Myung-Ho
authors.initials: MH
authors.lastname: Choi
authors.affiliation: Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.
authors.forename: Yeajee
authors.initials: Y
authors.lastname: Yim
authors.affiliation: Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.
authors.forename: Young-Kwan
authors.initials: YK
authors.lastname: Kim
authors.affiliation: Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.|Lemonex Inc, Seoul, 151-742, South Korea.
authors.forename: Dal-Hee
authors.initials: DH
authors.lastname: Min
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000494:pharmacology*; D006108:Graphite / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008027:Light; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010789:Phototherapy; D014025:Titanium / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; C009495:titanium dioxide; D006108:Graphite; D004317:Doxorubicin; D014025:Titanium
keywords: cancer therapy; drug delivery; graphene oxide; photodynamic therapy; photothermal therapy