title: Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells.
abstract: Natural killer (NK) cells are capable of identifying and killing tumor cells as well as virus infected cells without pre-sensitization. NK cells express activating and inhibitory receptors, and can distinguish between normal and tumor cells. The present study was designed to demonstrate the importance of the expression level of NKG2D ligands on the Burkitt's lymphoma cell line, Raji, in enhancing NK cell cytolytic activity. Various flavonoids were used as stimulants to enhance the expression of NKG2D ligands. NK cell lysis activity against Raji was not changed by pre-treatment of Raji with luteolin, kaempferol, taxifolin and hesperetin. However, treatment of Raji with naringenin showed increased sensitivity to NK cell lysis than untreated control cells. The activity of naringenin was due to enhanced NKG2D ligand expression. These results provide evidence that narigenin's antitumor activity may be due to targeting of NKG2D ligand expression and suggests a possible immunotherapeutic role for cancer treatment.
authors.affiliation: Department of Biology Education, College of Education, Chungbuk National University, Chungbuk, 361-763, Republic of Korea. lusia7942@chungbuk.ac.kr.|College of Pharmacy, Chungbuk National University, Chungbuk-do, 361-763, Republic of Korea. lusia7942@chungbuk.ac.kr.
authors.forename: Jeong Hwa
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Biology Education, College of Education, Chungbuk National University, Chungbuk, 361-763, Republic of Korea. chemokine@cbnu.ac.kr.
authors.forename: Jae Kwon
authors.initials: JK
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000276:immunology; D045744:Cell Line, Tumor; D044950:Flavanones / Q000494:pharmacology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents; D044950:Flavanones; D055655:NK Cell Lectin-Like Receptor Subfamily K; C005273:naringenin
keywords: Flavonoid; NKG2D ligands; Naringenin; Natural killer cell; Raji