title: The Relationship Between Medial Temporal Lobe Atrophy and Cognitive Impairment in Patients With Dementia With Lewy Bodies.
abstract: BACKGROUND
  The relationship between medial temporal lobe atrophy (MTA) and cognitive impairment in patients with dementia with Lewy bodies (DLB) remains unclear. We examined this relationship using voxel-based specific regional analysis system for Alzheimer disease (VSRAD) advance software, which allowed us to quantify the degree of MTA on images obtained from magnetic resonance imaging (MRI) scans.
  
  
  METHODS
  Thirty-seven patients diagnosed with DLB were recruited and scanned with a 1.5 Tesla MRI scanner. All MRI data were analyzed using VSRAD advance. The target volume of interest (VOI) included the entire region of the entorhinal cortex, hippocampus, and amygdala. The degree of MTA was obtained from the averaged positive z-score (Z score) on the target VOI, with higher scores indicating more severe MTA. Mini-Mental State Examination (MMSE) and the Revised Hasegawa Dementia Scale (HDS-R), which strengthened the measures of memory and language more than MMSE, were used to assess the presence of cognitive impairment.
  
  
  RESULTS
  A negative correlation was found between the Z score and MMSE total scores or the HDS-R total scores. A stepwise multiple regression analysis performed to adjust the covariate effects of sex, age, the onset age of the disease, duration of DLB, years of education, and donepezil treatment showed that the HDS-R total scores were independently associated with the Z score, whereas MMSE total scores were not.
  
  
  CONCLUSIONS
  These results suggest that MTA is related to cognitive impairment in patients with DLB, particularly the regions of orientation, immediate and delayed recall, and word fluency.
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan m2032247@med.osaka-cu.ac.jp.
authors.forename: Ryo
authors.initials: R
authors.lastname: Tagawa
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Nakanishi
authors.affiliation: Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
authors.forename: Youjirou
authors.initials: Y
authors.lastname: Kawarada
authors.affiliation: Department of Neurology and Psychiatry, Osaka City Kousaiin Hospital, Osaka, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Muramatsu
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Psychiatry, Cocoroa Hospital, Osaka, Japan.
authors.forename: Kouhei
authors.initials: K
authors.lastname: Kataoka
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Aiko
authors.initials: A
authors.lastname: Shimada
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Uchida
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Higashiyama
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Joji
authors.initials: J
authors.lastname: Kawabe
authors.affiliation: Department of Psychiatry, Osaka City General Hospital, Osaka, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kai
authors.affiliation: Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Shiomi
authors.affiliation: Department of Neuroscience, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Koki
authors.initials: K
authors.lastname: Inoue
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D000679:Amygdala / Q000473:pathology; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D000077265:Donepezil; D018728:Entorhinal Cortex / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D007802:Language; D020961:Lewy Body Disease / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D012984:Software; D013702:Temporal Lobe / Q000473:pathology* / Q000503:physiopathology*; D014705:Verbal Behavior
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil
keywords: DLB; MRI; VSRAD advance; dementia; neuroimaging