title: Lysine triggered ratiometric conversion of dynamic to static excimer of a pyrene derivative: aggregation-induced emission, nanomolar detection and human breast cancer cell (MCF7) imaging.
abstract: A simple pyrene based probe (A3) derived from pyrene-1-carboxaldehyde and 2-amino-1-phenylpropan-1-ol shows unique optical response triggered by the concentration of lysine (Lys). This allows selective nanomolar detection of Lys via a cascade of processes, dynamic to static-excimer conversion in a ratiometric manner followed by aggregation-induced emission (AIE). Imaging of Lys in the human breast cancer cell (MCF7) has been achieved.
authors.affiliation: Department of Chemistry, The University of Burdwan, Golapbag, Burdwan, India. ddas100in@yahoo.com.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Ghosh
authors.forename: Archya
authors.initials: A
authors.lastname: Sengupta
authors.forename: Ansuman
authors.initials: A
authors.lastname: Chattopadhyay
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
mesh_terms: D000586:Amination; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008239:Lysine / Q000032:analysis*; D061986:MCF-7 Cells; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D061848:Optical Imaging; D020005:Propanols / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D020005:Propanols; D011721:Pyrenes; C439395:1-phenylpropanol; C030984:pyrene; D008239:Lysine