title: Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study.
abstract: BACKGROUND
  Several studies suggest that Vitamin D (Vit-D3) supplementation reduces Chronic Urticaria (CU) symptoms.
  
  
  OBJECTIVE
  Evaluation of serum 25-hydroxyvitamin-D (25 (OH)2D) level and assessment of therapeutic effect of VitD3in CU patients.
  
  
  METHODS
  192 subjects were stratified according to the baseline 25(OH)2D levels and subsequently randomized into three subgroups to receive Vit-D3 alone (VD) or antihistamine and systemic corticosteroid (H+S) or VitD3 with antihistamine and systemic corticosteroid (VD+H+S) for 6 weeks between July 2012 to Oct 2014. 130 healthy controls (HC) were followed without any intervention. The patients were evaluated for reduction in urticarial symptoms using visual analogue scale (VAS) and 5-D itch score.
  
  
  RESULTS
  Low serum levels of 25 (OH)2D was observed in 91% of CU patients and 64% of the healthy controls (P < 0.0001). VAS and 5-D Score in subgroups VD, H + S and VD + H + S decreased significantly from 6 · 7 ± 0 · 043, 6 · 6 ± 0 · 42 and 6 · 68 ± 0 · 40 at baseline to 5 · 2 ± 0 · 70 (P = 0 · 0088), 3 · 3 ± 0 · 50 (P < 0 · 0001) and1 · 86 ± 0 · 39 (P < 0 · 0001) after treatment and from 14 · 5 ± 0 · 72, 13 · 9 ± 0 · 77 and 13 · 9 ± 0 · 221 to 12 · 06 ± 1 · 10 (P = 0 · 0072), 8 · 1 ± 1 · 13 (P < 0 · 0001) and 5 · 01 ± 0 · 94 (P < 0 · 0001) respectively.
  
  
  CONCLUSIONS
  CU patients have low serum 25(OH)2D levels and Vit-D3 supplementation in combination with antihistamine and systemic corticosteroid show elevated response in resolving the symptoms of CU. This study also warrants that each subject with CU should be screened for serum 25 (OH)2D levels before starting a treatment.
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Roohi
authors.initials: R
authors.lastname: Rasool
authors.affiliation: Division of Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K 190025 India.
authors.forename: Khalid Z
authors.initials: KZ
authors.lastname: Masoodi
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Irfan A
authors.initials: IA
authors.lastname: Shera
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Qayser
authors.initials: Q
authors.lastname: Yosuf
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Imtiyaz A
authors.initials: IA
authors.lastname: Bhat
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Qasim
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Saniya
authors.initials: S
authors.lastname: Nissar
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i- Kashmir Institute of Medical Sciences, Soura, Srinagar, J&K 190011 India.
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Shah
keywords: 25 (OH) vitamin D; 5-D itch score; Chronic Urticaria; IgE; Visual analogue scale