title: Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application.
abstract: Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion.
authors.affiliation: Department of Surgery and Transplantation, University Hospital Zürich, Raemistr. 100, 8091 Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Schlegel
authors.affiliation: Department of Surgery and Transplantation, University Hospital Zürich, Raemistr. 100, 8091 Zurich, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Kron
authors.affiliation: Department of Surgery and Transplantation, University Hospital Zürich, Raemistr. 100, 8091 Zurich, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Dutkowski
keywords: Hypothermic oxygenated perfusion; Ischemia-reperfusion injury; Mitochondria; ROS