title: Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development.
abstract: Contemporary management of neovascular age-related macular degeneration (AMD) has evolved significantly over the last few years. The goal of treatment is shifting from merely salvaging vision to maintaining a high quality of life. There have been significant breakthroughs in the identification of viable drug targets and gene therapies. Imaging tools with near-histological precision have enhanced our knowledge about pathophysiological mechanisms that play a role in vision loss due to AMD. Visual, social, and vocational rehabilitation are all important treatment goals. In this review, evidence from landmark clinical trials is summarized to elucidate the optimum modern-day management of neovascular AMD. Therapeutic strategies currently under development, such as gene therapy and personalized medicine, are also described.
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Rhoades
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hanout
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Mohamed Kamel
authors.initials: MK
authors.lastname: Soliman
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Salman
authors.initials: S
authors.lastname: Sarwar
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sadiq
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Yasir Jamal
authors.initials: YJ
authors.lastname: Sepah
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.affiliation: Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
keywords: AMD; VEGF; choroidal neovascular membrane; gene therapy; low-vision rehabilitation; neovascular AMD; pharmacogenomics