title: Comparative Application of PLS and PCR Methods to Simultaneous Quantitative Estimation and Simultaneous Dissolution Test of Zidovudine - Lamivudine Tablets.
abstract: In the development strategies of new drug products and generic drug products, the simultaneous in-vitro dissolution behavior of oral dosage formulations is the most important indication for the quantitative estimation of efficiency and biopharmaceutical characteristics of drug substances. This is to force the related field's scientists to improve very powerful analytical methods to get more reliable, precise and accurate results in the quantitative analysis and dissolution testing of drug formulations. In this context, two new chemometric tools, partial least squares (PLS) and principal component regression (PCR) were improved for the simultaneous quantitative estimation and dissolution testing of zidovudine (ZID) and lamivudine (LAM) in a tablet dosage form. The results obtained in this study strongly encourage us to use them for the quality control, the routine analysis and the dissolution test of the marketing tablets containing ZID and LAM drugs.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Üstündağ
authors.forename: Erdal
authors.initials: E
authors.lastname: Dinç
authors.forename: Nurten
authors.initials: N
authors.lastname: Özdemir
authors.forename: M Günseli
authors.initials: MG
authors.lastname: Tilkan
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry*; D004338:Drug Combinations; D019259:Lamivudine / Q000737:chemistry*; D016018:Least-Squares Analysis; D025341:Principal Component Analysis; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D015215:Zidovudine / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004338:Drug Combinations; D018894:Reverse Transcriptase Inhibitors; D013607:Tablets; C109078:lamivudine, zidovudine drug combination; D019259:Lamivudine; D015215:Zidovudine