title: Down Syndrome with Patent Ductus Venosus and Hepato-Biliary-Pancreatic Abnormalities.
abstract: The association between Down syndrome and congenital portosystemic shunts, most commonly caused by patent ductus venosus, remains relatively unknown. The authors present a girl with Down syndrome with patent ductus venosus, pancreaticobiliary maljunction and paucity of interlobular bile ducts, presenting with neonatal cholestasis and transient abnormal myeloproliferative disorder. To the best of authors' knowledge, no report of the concurrent presence of the above in Down syndrome has been published.
authors.affiliation: Department of Pediatrics, Teine Keijinkai Hospital, 1 Jo 12-1-40, Maeda, Teine-ku, Sapporo, Japan. sunamausu_kyu@oasis.ocn.ne.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Department of Pediatrics, Teine Keijinkai Hospital, 1 Jo 12-1-40, Maeda, Teine-ku, Sapporo, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kosugiyama
authors.affiliation: Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Honda
authors.affiliation: Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Japan.
authors.forename: Okada
authors.initials: O
authors.lastname: Tadao
authors.affiliation: Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Japan.
authors.forename: Akinobu
authors.initials: A
authors.lastname: Taketomi
authors.affiliation: Department of Pediatrics, Teine Keijinkai Hospital, 1 Jo 12-1-40, Maeda, Teine-ku, Sapporo, Japan.
authors.forename: Seido
authors.initials: S
authors.lastname: Iwata
mesh_terms: D001659:Biliary Tract / Q000002:abnormalities / Q000000981:diagnostic imaging; D002758:Cholangiography / Q000379:methods; D004065:Digestive System Abnormalities / Q000175:diagnosis / Q000601:surgery; D019468:Disease Management; D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007955:Leukemoid Reaction / Q000150:complications* / Q000175:diagnosis; D008099:Liver / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D010179:Pancreas / Q000002:abnormalities / Q000000981:diagnostic imaging; D011169:Portal Vein / Q000002:abnormalities* / Q000503:physiopathology; D014463:Ultrasonography / Q000379:methods; D054079:Vascular Malformations / Q000175:diagnosis / Q000503:physiopathology
keywords: Down syndrome; Neonatal cholestasis; Patent ductus venosus; Portosystemic shunt