title: Clinicopathological characteristics and prognosis of patients with adenosquamous lung carcinoma.
abstract: This study was aimed to characterize clinicopathological features and prognosis of patients with adenosquamous lung carcinoma (ASC). Among the 2531 patients with lung cancer who underwent surgery between January 2000 and June 2012 in our hospital, 59 were histologically diagnosed as having ASC. The clinicopathological features and follow-up data of ASC patients were collected and analyzed statistically. Superior lobectomy was accomplished in 40 patients, middle and inferior lobectomy in 3, lobectomy plus partial resection of contralateral lung in 5, partial lung resection in 4, and pneumonectomy in 7. Moreover, 22 cases were found to be adenocarcinoma-predominant, and 18 to be squamous cell carcinoma-predominant. The median survival time was 13.6 months, and the 1-, 3-, and 5-year survival rates were 59.9%, 36.4% and 31.2%, respectively. Of the 52 cases with tissue specimens available, 11 had an EGFR mutation (21.2%) and 2 had a KRAS mutation (3.8%). Multivariate analysis showed that histology subtype, pleural invasion, TNM stage, and postoperative treatment were all independent prognostic factors. The data from the current study demonstrated that SCC-predominant histology represents a better prognosis of ASC. Histology subtype, pleural invasion, TNM stage, and postoperative treatment are independent prognostic factors for ASC and adjuvant therapy may help control the disease.
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Guo-Guang
authors.initials: GG
authors.lastname: Shao
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Sun
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Xing-Xing
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Guan-Jun
authors.initials: GJ
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Hospital of Jilin University, Changchun, 130021, China. makw@jlu.edu.cn.
authors.forename: Ke-Wei
authors.initials: KW
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: C117307:KRAS protein, human; C512478:EGFR protein, human; D066246:ErbB Receptors; D016283:Proto-Oncogene Proteins p21(ras)