title: [Hypoglycaemic coma revealing a malignant recurrence during Doege-Potter syndrome].
abstract: BACKGROUND
  The Doege-Potter syndrome is a rare paraneoplastic syndrome, first described by Doege and Potter in 1930, that usually involves solid fibrous pleural tumours. Hypoglycaemia is a rare complication of these tumours, due to secretion of insulin-like growth factors, and it can be the presenting symptom. The incidence of malignancy is low, about 12-15 %.
  
  
  METHODS
  An 81-year-old Caucasian man, operated on 20 years previously for a benign pleural fibroma, presented with several episodes of loss of consciousness due to profound hypoglycaemia and a history of increasing dyspnea. The chest X-ray revealed an intrathoracic mass. Following excision histological examination confirmed recurrence with malignant transformation to a high-grade sarcoma.
  
  
  CONCLUSIONS
  The Doege-Potter syndrome is a rare condition but it should be suspected in episodes of hypoglycaemia associated with a history of dyspnea. These patients should be followed up postoperatively because of the risk of tumour recurrence.
authors.affiliation: Service de pathologie respiratoire et d'allergologie, hôpital du Cluzeau, CHU de Limoges, 23, avenue Dominique-Larrey, 87042 Limoges cedex, France. Electronic address: eve.lc@free.fr.
authors.forename: E-M
authors.initials: EM
authors.lastname: Le Coustumier
authors.affiliation: Service d'oncologie médicale, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France.
authors.forename: E
authors.initials: E
authors.lastname: Vandeix
authors.affiliation: Service d'anatomopathologie et de cytologie, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Delage-Corre
authors.affiliation: Service de chirurgie thoracique et cardiovasculaire, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Bertin
authors.affiliation: Service de pathologie respiratoire et d'allergologie, hôpital du Cluzeau, CHU de Limoges, 23, avenue Dominique-Larrey, 87042 Limoges cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Melloni
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D003128:Coma / Q000209:etiology*; D018450:Disease Progression; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000378:metabolism*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010997:Pleural Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D054363:Solitary Fibrous Tumor, Pleural / Q000473:pathology / Q000601:surgery; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D007335:Insulin-Like Growth Factor II
keywords: Doege-Potter syndrome; Dyspnea; Dyspnée; Hypoglycaemia; Hypoglycémie; Pleural tumour; Solitary fibrous tumour; Syndrome de Doege-Potter; Tumeur fibreuse solitaire; Tumeur pleurale