title: Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes.
abstract: Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.
authors.affiliation: Departamento de Biología Molecular, Universidad de Cantabria-IDIVAL, 39011, Santander, Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: García-Hevia
authors.affiliation: Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Cantabria-IDIVAL, 39005, Santander, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Valiente
authors.affiliation: Hospital Valdecilla-IDIVAL, 39011, Santander, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Fernández-Luna
authors.affiliation: CNRS, Institut Carnot CIRIMAT, Université de Toulouse, F-31062, Toulouse, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Flahaut
authors.affiliation: SERMET, Universidad de Cantabria, 39005, Santander, Spain.
authors.forename: Lidia
authors.initials: L
authors.lastname: Rodríguez-Fernández
authors.affiliation: Departamento de Anatomía y Biología Celular, Universidad de Cantabria-IDIVAL, 39011, Santander, Spain.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Villegas
authors.affiliation: MALTA-Consolider Team, CITIMAC, Facultad de Ciencias, Universidad de Cantabria-IDIVAL, 39005, Santander, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: González
authors.affiliation: Departamento de Biología Molecular, Universidad de Cantabria-IDIVAL, 39011, Santander, Spain.
authors.forename: Mónica L
authors.initials: ML
authors.lastname: Fanarraga
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D008870:Microtubules; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000633:toxicity; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D013059:Spectrum Analysis, Raman
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon
keywords: biomechanics; cancer; cytoskeleton; metastasis; tubulin polymers