title: Inverse Levels of Adiponectin in Type 1 and Type 2 Diabetes Are in Accordance with the State of Albuminuria.
abstract: Aims. To investigate the behaviour of adiponectin (ApN) in patients with type 1 and type 2 diabetic nephropathy. Methods. ApN and inflammatory and other markers of the metabolic syndrome were compared across diabetes types, albumin excretion rate (AER), and creatinine clearance (CrCl) categories in 219 type 1 and type 2 diabetic patients. Results. Significant differences among ApN levels according to AER were found in both types of diabetes (F = 8.45, df = 2, P < 0.001). With the progression of albuminuria, ApN increased in type 1 and decreased in type 2 diabetes. Patients with decreased CrCl had higher ApN levels than those with normal CrCl in either type of diabetes (F = 12.7, df = 1, P < 0.001). The best model for ApN (R (2) = 0.9002) obtained from stepwise regression in type 1 diabetes included CrCl, BMI, WBC, CRP, and age, while in type 2 diabetes (R (2) = 0.2882) it included ppPG, LDL, and UA. Conclusion. ApN behaved differently in relation to albuminuria, increasing with its progression in type 1 diabetes and decreasing in type 2 diabetes. It was however increased in the subgroups with decreased CrCl in both types of diabetes. Albuminuria seems to be more important than renal insufficiency in the definition of ApN levels in type 1 and type 2 diabetes.
authors.affiliation: Department of Endocrinology and Metabolic Disease, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
authors.forename: Spomenka
authors.identifier: 0000-0002-9631-3890
authors.initials: S
authors.lastname: Ljubic
authors.affiliation: Faculty of Forestry, University of Zagreb, Svetosimunska 25, 10000 Zagreb, Croatia.
authors.forename: Anamarija
authors.initials: A
authors.lastname: Jazbec
authors.affiliation: Department of Ophthalmology, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
authors.forename: Martina
authors.initials: M
authors.lastname: Tomic
authors.affiliation: Department of Endocrinology and Metabolic Disease, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
authors.forename: Ante
authors.initials: A
authors.lastname: Piljac
authors.affiliation: Department of Internal Medicine, Rijeka University Hospital Center, Kresimirova 42, 51000 Rijeka, Croatia.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Jurisic Erzen
authors.affiliation: Department of Diabetes, Vuk Vrhovac University Clinic, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
authors.forename: Branko
authors.initials: B
authors.lastname: Novak
authors.affiliation: Department of Ophthalmology, Dubrava Clinical Hospital, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.
authors.forename: Snjezana
authors.initials: S
authors.lastname: Kastelan
authors.affiliation: Department of Laboratory Medicine, Merkur University Hospital, 10000 Zagreb, Croatia.
authors.forename: Marijana Vucic
authors.initials: MV
authors.lastname: Lovrencic
authors.affiliation: Department of Cardiology, Merkur University Hospital, Zajceva 19, 10000 Zagreb, Croatia.
authors.forename: Neva
authors.initials: N
authors.lastname: Brkljacic