title: Iatrogenic Baclofen Neurotoxicity in ESRD: Recognition and Management.
abstract: Baclofen is an oral derivative of gamma-aminobutyric acid (GABA) used to treat muscular spasticity from disorders of the central nervous system. However, it is also being used for a variety of other conditions such as musculoskeletal pain, myoclonus, and alcohol withdrawal. The elimination of baclofen is heavily dependent on intact renal function, and the contraindication for use in patients with insufficient renal function is not well recognized by healthcare providers. Here, the authors report a series of mild to severe cases of baclofen intoxication in patients with end-stage renal disease. In all cases, baclofen was initiated by either inpatient or outpatient healthcare providers and the patients generally presented with altered mentation, somnolence, and/or respiratory depression. All patients were treated with aggressive hemodialysis and made a full recovery. This paper will briefly review the literature regarding baclofen intoxication, safety of baclofen use in renal disease, and efficacy of extracorporeal therapy in the treatment of baclofen intoxication.
authors.affiliation: Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: John K
authors.initials: JK
authors.lastname: Roberts
authors.affiliation: Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: Scott
authors.initials: S
authors.lastname: Westphal
authors.affiliation: Division of Nephrology and Department of Medicine, Duke University and Durham Veterans Affairs Medical Centers, Durham, North Carolina.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Sparks
mesh_terms: D000368:Aged; D001418:Baclofen / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D058786:GABA-B Receptor Agonists / Q000009:adverse effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed
chemical_list: D058786:GABA-B Receptor Agonists; D001418:Baclofen