title: Complex and dynamic expression of cadherins in the embryonic marmoset cerebral cortex.
abstract: Cadherin is a cell adhesion molecule widely expressed in the nervous system. Previously, we analyzed the expression of nine classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh9, Cdh10, Cdh11, Cdh12, and Cdh20) and T-cadherin (Cdh13) in the developing postnatal common marmoset (Callithrix jacchus) brain, and found differential expressions between mice and marmosets. In this study, to explore primate-specific cadherin expression at the embryonic stage, we extensively analyzed the expression of these cadherins in the developing embryonic marmoset brain. Each cadherin showed differential spatial and temporal expression and exhibited temporally complicated expression. Furthermore, the expression of some cadherins differed from that in rodent brains, even at the embryonic stage. These results suggest the possibility that the differential expressions of diverse cadherins are involved in primate specific cortical development, from the prenatal to postnatal period.
authors.affiliation: Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, 351-0198, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsunaga
authors.affiliation: Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, 351-0198, Japan.
authors.forename: Sanae
authors.initials: S
authors.lastname: Nambu
authors.affiliation: Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, 351-0198, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Oka
authors.affiliation: Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, 351-0198, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iriki
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D002144:Callithrix / Q000196:embryology / Q000235:genetics; D002540:Cerebral Cortex / Q000196:embryology* / Q000378:metabolism; D004622:Embryo, Mammalian; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006624:Hippocampus / Q000196:embryology / Q000378:metabolism; D008297:Male; D038081:Organogenesis / Q000235:genetics*; D011247:Pregnancy
chemical_list: D015820:Cadherins
keywords: cadherin; embryo; gene expression; marmoset; neocortex