title: Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population.
abstract: OBJECTIVE
  To investigate the association between colorectal cancer (CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population.
  
  
  METHODS
  A case-control study was conducted including 360 esophageal cancer patients and 310 healthy controls. Thirty-one single-nucleotide polymorphisms (SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from Hardy-Weinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ(2) test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models (codominant, dominant, recessive, overdominant, and additive). ORs and 95%CIs were calculated by unconditional logistic regression with adjustments for age and sex.
  
  
  RESULTS
  The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010). The rs4939827 C/T-T/T genotype was associated with a 0.67-fold (95%CI: 0.46-0.98; P = 0.038) decreased esophageal cancer risk under the dominant model. In addition, rs6687758, rs1321311, and rs4444235 were associated with an increased risk. In particular, the T/T genotype of rs1321311 was associated with an 8.06-fold (95%CI: 1.96-33.07; P = 0.004) increased risk in the codominant model.
  
  
  CONCLUSIONS
  These results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors.
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Geng
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Xun
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Li
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Tian-Bo
authors.initials: TB
authors.lastname: Jin
authors.affiliation: Ting-Ting Geng, Li-Ping Wang, Peng Hou, Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor
keywords: Colorectal cancer; Esophageal cancer; Single-nucleotide polymorphism; Susceptibility