title: [Neuromyelitis optica and aquaporin-associated syndromes].
abstract: Identification of aquaporin-4 antibodies in neuromyelitis optica (NMO) is highly important to provide early diagnosis for starting pathogenetic treatment, and for differential diagnosis in neuromyelitis optica spectrum disorders (NMO-SD). In this paper, we review current pathogenetic and clinical aspects of NMO and NMO NMO-SD. We present our data on the identification of aquaporin-4 antibodies in CNS disorders. Aquaporin-4 antibodies were detected in 86.36% of patients with neuromyelitis optica, in 12.5% of patients with partial syndromes and in 100% of patients with systemic lupus erythematosus with longitudinally extensive transverse myelitis or optic neuritis. There was the correlation between the extent of lesion in the spinal cord and positive aquaporin-4 antibodies.
authors.affiliation: Neurology Research Center, Moscow.
authors.forename: T O
authors.initials: TO
authors.lastname: Simaniv
authors.affiliation: Neurology Research Center, Moscow.
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'eva
authors.affiliation: Neurology Research Center, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Smirnova
authors.affiliation: Gamaleja Research Institute of Epidemiology and Microbiology, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Zigangirova
authors.affiliation: Neurology Research Center, Moscow.
authors.forename: M N
authors.initials: MN
authors.lastname: Zakharova