title: Neurologic Complications of Psychomotor Stimulant Abuse.
abstract: Psychomotor stimulants are drugs that act on the central nervous system (CNS) to increase alertness, elevate mood, and produce a sense of well-being. These drugs also decrease appetite and the need for sleep. Stimulants can enhance stamina and improve performance in tasks that have been impaired by fatigue or boredom. Approved therapeutic applications of stimulants include attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. These agents also possess potent reinforcing properties that can result in excessive self-administration and abuse. Chronic use is associated with adverse effects including psychosis, seizures, and cerebrovascular accidents, though these complications usually occur in individuals with preexisting risk factors. This chapter reviews the adverse neurologic consequences of chronic psychomotor stimulant use and abuse, with a focus on two prototypical stimulants methamphetamine and cocaine.
authors.affiliation: Ellis Endowed Chair of Neurology, University of South Florida, Tampa, Florida, USA. Electronic address: jsramos@health.usf.edu.
authors.forename: Juan
authors.initials: J
authors.lastname: Sanchez-Ramos
mesh_terms: D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D004361:Drug Tolerance; D004409:Dyskinesia, Drug-Induced; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*; D020521:Stroke / Q000139:chemically induced*; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D000697:Central Nervous System Stimulants
keywords: Abuse; Amphetamine; Cocaine; Dependence; Movement disorders; Psychosis; Punding; Seizures; Stroke