title: Adaptive Ridge Point Refinement for Seeds Detection in X-Ray Coronary Angiogram.
abstract: Seed point is prerequired condition for tracking based method for extracting centerline or vascular structures from the angiogram. In this paper, a novel seed point detection method for coronary artery segmentation is proposed. Vessels on the image are first enhanced according to the distribution of Hessian eigenvalue in multiscale space; consequently, centerlines of tubular vessels are also enhanced. Ridge point is extracted as candidate seed point, which is then refined according to its mathematical definition. The theoretical feasibility of this method is also proven. Finally, all the detected ridge points are checked using a self-adaptive threshold to improve the robustness of results. Clinical angiograms are used to evaluate the performance of the proposed algorithm, and the results show that the proposed algorithm can detect a large set of true seed points located on most branches of vessels. Compared with traditional seed point detection algorithms, the proposed method can detect a larger number of seed points with higher precision. Considering that the proposed method can achieve accurate seed detection without any human interaction, it can be utilized for several clinical applications, such as vessel segmentation, centerline extraction, and topological identification.
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China ; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Room C249, Beijing 100084, China.
authors.forename: Ruoxiu
authors.identifier: 0000-0003-3959-9797
authors.initials: R
authors.lastname: Xiao
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Jian
authors.identifier: 0000-0003-1250-6319
authors.initials: J
authors.lastname: Yang
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Danni
authors.initials: D
authors.lastname: Ai
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Jingfan
authors.initials: J
authors.lastname: Fan
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Room C249, Beijing 100084, China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Wang
authors.affiliation: Key Laboratory of Photoelectronic Imaging Technology and System, Ministry of Education of China, School of Optics and Electronics, Beijing Institute of Technology, Beijing 100081, China.
authors.forename: Yongtian
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D015901:Angiography, Digital Subtraction / Q000706:statistics & numerical data; D019295:Computational Biology; D017023:Coronary Angiography / Q000706:statistics & numerical data*; D005240:Feasibility Studies; D006801:Humans; D008955:Models, Cardiovascular; D015233:Models, Statistical; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods