title: Optical Imaging: Future Tool in Detection of Pre-cancerous and Cancerous Lesions of Cervix and Its Comparison to Colposcopy.
abstract: OBJECTIVE
  To study the diagnostic potential of optical imaging and its comparison with colposcopy, in detecting early cervical dysplasia.
  
  
  METHODS
  The study was conducted on 200 patients attending the outdoor of UISE maternity hospital with symptoms suspicious of cervical lesions. All patients were subjected to colposcopy, followed by histo-pathological examination. Out of all HPE, 18 samples each from normal and dysplastic histology were sent to IIT Physics lab, Kanpur for optical imaging. Statistical analysis was done using sensitivity, specificity, PPV, and NPV. Chi square test was applied to calculate p value.
  
  
  RESULTS
  In optical imaging, depolarization images had shown significant changes in the epithelium region of the dysplastic tissue as compared to normal one. It is found that the mean value of depolarization power for normal cervix tissues is less than 0.32, while for dysplastic tissues it is greater than 0.32.
  
  
  CONCLUSIONS
  Optical imaging is fast, non-invasive tool with high sensitivity and specificity, comparable to colposcopy (sensitivity 88.9 vs 100 %, specificity 83.3 vs 86.6 %) and thus is useful in both for screening and diagnosis of cervical dysplasia.
authors.affiliation: Department of Obstetrics and Gynecology, G.S.V.M. Medical College, Flat No. 104, Narayandeep Appt., 7/81, Tilaknagar, Kanpur, 208002 UP India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Pandey
authors.affiliation: Department of SPM, G.S.V.M. Medical College, Kanpur, UP India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Bhagoliwal
authors.affiliation: Department of Obstetrics and Gynecology, G.S.V.M. Medical College, Flat No. 104, Narayandeep Appt., 7/81, Tilaknagar, Kanpur, 208002 UP India.
authors.forename: Sonal
authors.initials: S
authors.lastname: Jain
keywords: Cancer cervix; Colposcopy; Depolarization power; Optical imaging