title: Macrophages and Uveitis in Experimental Animal Models.
abstract: Resident and infiltrated macrophages play relevant roles in uveitis as effectors of innate immunity and inductors of acquired immunity. They are major effectors of tissue damage in uveitis and are also considered to be potent antigen-presenting cells. In the last few years, experimental animal models of uveitis have enabled us to enhance our understanding of the leading role of macrophages in eye inflammation processes, including macrophage polarization in experimental autoimmune uveoretinitis and the major role of Toll-like receptor 4 in endotoxin-induced uveitis. This improved knowledge should guide advantageous iterative research to establish mechanisms and possible therapeutic targets for human uveitis resolution.
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Mérida
authors.affiliation: FISABIO, Oftalmología Médica, 46020 Valencia, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Palacios
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, Spain ; FISABIO, Oftalmología Médica, 46020 Valencia, Spain.
authors.forename: Amparo
authors.identifier: 0000-0002-9856-5370
authors.initials: A
authors.lastname: Navea
authors.affiliation: Instituto de Ciencias Biomédicas, Universidad CEU Cardenal Herrera, 46113 Valencia, Spain ; FISABIO, Oftalmología Médica, 46020 Valencia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Bosch-Morell
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D004195:Disease Models, Animal; D008264:Macrophages / Q000276:immunology / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D014605:Uveitis / Q000276:immunology / Q000378:metabolism*
chemical_list: D051197:Toll-Like Receptor 4