title: Arterial blood pressure targets in septic shock: is it time to move to an individualized approach?
abstract: Xu and colleagues evaluated the impact of increasing mean arterial blood pressure levels through norepinephrine administration on systemic hemodynamics, tissue perfusion, and sublingual microcirculation of septic shock patients with chronic hypertension. The authors concluded that, although increasing arterial blood pressure improved sublingual microcirculation parameters, no concomitant improvement in systemic tissue perfusion indicators was found. Here, we discuss why resuscitation targets may need to be individualized, taking into account the patient's baseline condition, and present directions for future research in this field.
authors.affiliation: Intensive Care Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, São Paulo, 05652-000, Brazil.|Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10, CH-3010, Bern, Switzerland.
authors.forename: Thiago Domingos
authors.initials: TD
authors.lastname: Corrêa
authors.affiliation: Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10, CH-3010, Bern, Switzerland. stephan.jakob@insel.ch.
authors.forename: Stephan Matthias
authors.initials: SM
authors.lastname: Jakob
authors.affiliation: Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10, CH-3010, Bern, Switzerland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Takala
mesh_terms: D062186:Arterial Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D012772:Shock, Septic / Q000188:drug therapy*