title: [Effect of Clopidogrel on Pharmacokinetic of Fufang Danshen Dripping Pill (FDDP)].
abstract: OBJECTIVE
  To investigate the effect of clopidogrel on the pharmacokinetic of Fufang Danshen Dripping Pill (FDDP);
  
  
  METHODS
  20 SD rats were randomly divided into two group,which were intrinsically administrated FDDP(324 mg/kg) alone and combination of FDDP(324 mg/kg) and clopidogrel(30 mg/kg) respectively for 21 days. The ginsenoside Rg, from FDDP was determined by HPLC and its pharmacokinetic parameter were finally compared.
  
  
  RESULTS
  The value of Cmax and AUC0-∞ of ginsenoside Rg, were increased from 1.97 ± 0.44 mg/L and 8.44 ± 2.64 mg/L · h to 2.48 ± 0.63 mg/L and 14.38 ± 5.72 mg/L · h respectively.
  
  
  CONCLUSIONS
  Long term with clopidogrel has effect on the pharmacokinetic character of Rg, from FDDP, this research may provides theoretical support for the FDDP-clopidogrel combination treatment in clinical.
authors.forename: Shi-tang
authors.initials: ST
authors.lastname: Ma
authors.forename: Guo-liang
authors.initials: GL
authors.lastname: Dai
authors.forename: Bing-ting
authors.initials: BT
authors.lastname: Sun
authors.forename: Wen-zhu
authors.initials: WZ
authors.lastname: Zhao
authors.forename: Wen-zheng
authors.initials: WZ
authors.lastname: Ju
authors.forename: Heng-shan
authors.initials: HS
authors.lastname: Tan
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D000077144:Clopidogrel; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D036145:Ginsenosides / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C517866:fufang danshen; D000077144:Clopidogrel; D013988:Ticlopidine