title: Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction.
abstract: Abuse of and addiction to psychostimulants remains a challenging clinical issue; yet no effective pharmacotherapy is available. Trace amine associated receptor 1 (TAAR 1) is increasingly recognized as a novel drug target that participates in the modulation of drug abuse. This review analyzed existing preclinical evidence from electrophysiological, biochemical to behavioral aspects regarding the functional interactions between TAAR 1 and dopaminergic system. TAAR 1 knockout mice demonstrate increased sensitivity to dopaminergic activation while TAAR 1 agonists reduce the neurochemical effects of cocaine and amphetamines, attenuate abuse- and addiction-related behavioral effects of cocaine and methamphetamine. It is concluded that TAAR 1 activation functionally modulates the dopaminergic activity and TAAR 1 agonists appear to be promising pharmacotherapies against psychostimulant addiction.
authors.affiliation: Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA; Department of Physiology and Pathophysiology, Tianjin Me dical University, Tianjin, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.affiliation: Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA. Electronic address: junxuli@buffalo.edu.
authors.forename: Jun-Xu
authors.initials: JX
authors.lastname: Li
mesh_terms: D019969:Amphetamine-Related Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D000818:Animals; D016739:Behavior, Addictive; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D059290:Dopaminergic Neurons / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008694:Methamphetamine / Q000009:adverse effects*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D000095383:Trace Amine-Associated Receptors
chemical_list: D000697:Central Nervous System Stimulants; D008024:Ligands; D008694:Methamphetamine; D043562:Receptors, G-Protein-Coupled; D000095383:Trace Amine-Associated Receptors
keywords: Addiction; Behavior; Cocaine; Methamphetamine; TAAR 1