title: [Cerebrovascular reactivity in patients with rheumatoid arthritis concurrent with and without hypertension].
abstract: OBJECTIVE
  To compare cerebrovascular reactivity (CVR) in patients with rheumatoid arthritis (RA) concurrent with essential hypertension (Group 1) and in those with RA and normal blood pressure (BP) (Group 2).
  
  
  METHODS
  During the study of Groups 1 (n = 37) and 2 (n = 12), the investigators estimated the prevalence of traditional cardiovascular risk factors, performed 24-hour BP monitoring, investigated CVR by transcranial Doppler (TCD) of the middle cerebral arteries (MCA) by hyperoxic and hypercapnic tests, and endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation of the brachial artery. The groups were matched for gender, age, RA activity and stage, and antirheumatic therapy volume.
  
  
  RESULTS
  According to the results of MCA TCD, the hyperoxic test recorded impaired CVR in 34 (92%) and 10 (83%) patients in Group 1 and 2, respectively; the hypercapnic test revealed this condition in 19 (51%) and 6 (50%) patients in these groups, respectively. The hyperoxic test most commonly showed an insufficient decrease in MCA linear blood flow velocities (LBFV) in 31 (84%) and 8 (66%) patients in Groups 1 and 2, respectively; the hypercapnic test did an excessive increase in MCA LBFV in 12 (32%) and 4 (33%) patients, respectively. There was a high rate of impaired EDV in 32 (86%) and 9 (75%) patients in Groups 1 and 2, respectively.
  
  
  CONCLUSIONS
  According to the results of MCA TCD, there were high and similar rates of impaired CVR in patients with RA concurrent with and without essential hypertension during the hyperoxic and hypercapnic tests.
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Rebrova
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Anisimova
authors.affiliation: Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
authors.forename: O L
authors.initials: OL
authors.lastname: Sarkisova
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Mordovin
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
authors.forename: R S
authors.initials: RS
authors.lastname: Karpov
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: T M
authors.initials: TM
authors.lastname: Ripp
authors.affiliation: Siberian State Medical University, Ministry of Health of Russia, Tomsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Trifonova
authors.affiliation: Department of Arterial Hypertension, Research Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: I I
authors.initials: II
authors.lastname: Bogomolova
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017585:Ultrasonography, Doppler, Transcranial; D014655:Vascular Resistance / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*