title: High mobility group A1 expression shows negative correlation with recurrence time in patients with glioblastoma multiforme.
abstract: The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM. Paired initial and recurrent GBM specimens from the same patient were evaluated using immunohistochemical analysis. The association between HMGA1 expression and progression-free survival time (PFST) was analyzed. Three patients were confirmed with IDH-1 R132H mutations in both initial and recurrent groups (3/25, 12%). There was a significant difference in HMGA1 expression between initial and recurrent GBM (P=0.002), and patients with tumors expressing HMGA1 at higher level had a significantly shorter PFST (7.3 months versus 11.1months; P=0.044). Our study indicates that recurrent GBM express HMGA1 at a higher level and that HMGA1 overexpressoin is associated with shorter PFST in patients with GBM. These findings suggest that HMGA1 potentially plays an important role in the treatment of GBM.
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China; Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, Japan.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Shandong University Graduate School of Medicine, Jinan 250012, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Pang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Huajie
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Arakawa
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Feng
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhong
authors.affiliation: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, Japan.
authors.forename: Daiki
authors.initials: D
authors.lastname: Murata
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xin
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China. Electronic address: guohua71@hotmail.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Liming
authors.initials: L
authors.lastname: Luan
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China.
authors.forename: Shangchen
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606-8527, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyamoto
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, PR China. Electronic address: pangqisdu@126.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D024003:HMGA Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology*
chemical_list: D024003:HMGA Proteins; D007521:Isocitrate Dehydrogenase
keywords: Glioblastoma multiforme; High mobility group A1; Isocitrate dehydrogenase 1 mutation; Progression-free survival time; Recurrence