title: Linking Micronuclei to Chromosome Fragmentation.
abstract: Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.
authors.affiliation: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA.
authors.forename: Emily M
authors.initials: EM
authors.lastname: Hatch
authors.affiliation: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA. Electronic address: hetzer@salk.edu.
authors.forename: Martin W
authors.initials: MW
authors.lastname: Hetzer
mesh_terms: D019457:Chromosome Breakage; D004249:DNA Damage; D006801:Humans; D048629:Micronuclei, Chromosome-Defective