title: Impact of cinacalcet pre-transplantation on mineral metabolism in renal transplant recipients.
abstract: OBJECTIVE
  Cinacalcet is effective in reducing parathyroid hormone (PTH) in patients on dialysis. Reports of biochemical profiles and other clinical outcomes in patients discontinuing cinacalcet at time of renal transplantation are limited.
  
  
  METHODS
  A retrospective study assessing markers of mineral metabolism, graft and patient outcomes in renal transplant recipients to determine differences in patients discontinuing cinacalcet (C+) compared with patients not treated with cinacalcet (C-) at time of transplantation. To allow for differences between groups in pre-transplant biochemical parameters, we also analysed a matched cohort of C- with C+ recipients (2:1), matched for age, calcium and PTH levels at transplantation.
  
  
  RESULTS
  Five hundred thirty-two recipients (460 C-, 72 C+), transplanted January 2006-December 2012, were analysed, mean age 48.0 ± 12.7 years and 64.3% were men. At a median 42.9 months follow up, there were 10 deaths (1.9%), 56 allograft loss (10.6%) and 5 parathyroidectomies post-transplant (0.8%). Median PTH immediately pre-transplant was higher in C+ versus C- (50.7(25.4-75.2) versus 28.3(13.9-49.7) pmol/L, P < 0.001). Twelve-month post-transplant PTH was reduced but higher in C+ (11.7(6.9-21.2) vs 7.2(4.6-11.2) pmol/L, P < 0.001). Mean calcium was higher for C+ versus C- at 12 months (2.50 ± 0.19 vs 2.43 ± 0.17 mmol/L, P < 0.001), with differences to 4 years post-transplant. No difference was seen in renal function, graft loss, post-transplant parathyroidectomy rate and mortality. In the matched cohort (144 C- vs 72 C+), similar findings were also seen.
  
  
  CONCLUSIONS
  Differences in mineral metabolism post-transplant are seen with cinacalcet pre-transplant compared with no cinacalcet. Transplant recipients discontinuing cinacalcet had higher post-transplant PTH and calcium although the clinical significance is unclear.
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.|Department of Medicine (RMH), The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Masterson
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.|Department of Medicine (RMH), The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Holt
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.|Department of Medicine (RMH), The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Sven-Jean
authors.initials: SJ
authors.lastname: Tan
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Hughes
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
authors.forename: Melissa
authors.initials: M
authors.lastname: Chu
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
authors.forename: Pavithra
authors.initials: P
authors.lastname: Jayadeva
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.|Department of Medicine (RMH), The University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Nigel D
authors.initials: ND
authors.lastname: Toussaint
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D057966:Calcimimetic Agents / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood*; D000069449:Cinacalcet / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy; D006435:Renal Dialysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014739:Victoria
chemical_list: D015415:Biomarkers; D057966:Calcimimetic Agents; C470125:PTH protein, human; D010281:Parathyroid Hormone; D002118:Calcium; D000069449:Cinacalcet
keywords: calcimimetic; cinacalcet; hypercalcaemia; mineral metabolism; renal transplantation; secondary hyperparathyroidism