title: DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde.
abstract: In this issue of Immunity, Conde et al. (2015) showed that a costimulatory blockade favors the accumulation of CD209a(+) macrophages which, upon interaction with fucosylated tissue ligands, promotes the expansion of CD4(+)Foxp3(+) Treg cell number.
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam MF-B242, 1081BT, the Netherlands. Electronic address: jj.garciavallejo@vumc.nl.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Garcia-Vallejo
authors.affiliation: Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam MF-B242, 1081BT, the Netherlands. Electronic address: y.vankooyk@vumc.nl.
authors.forename: Yvette
authors.initials: Y
authors.lastname: van Kooyk
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation; D037181:Lectins, C-Type / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface