title: Global Tests in Evaluation of the Function of Pro-and Anticoagulant Systems: Present and Future.
abstract: Comparative analysis of the effectiveness of global tests for evaluation of the blood coagulation systems demonstrated the possibility of obtaining express data on hemostasis stages I-II and III when working with native substrate (whole blood). Changes in viscous characteristics of the whole blood recorded ex vivo during hemocoagulation allowed us to propose the concept of permanency of fibrinogenesis as the obligatory in vivo process determining the hemostatic potential, an integral characteristic of the hemocoagulation cycle providing sufficient blood fluidity and limiting extravasation of blood components under conditions of permeability disturbances and damage to the vascular wall.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: I I
authors.initials: II
authors.lastname: Tyutrin
authors.forename: M A
authors.initials: MA
authors.lastname: Solov'ev
authors.forename: V F
authors.initials: VF
authors.lastname: Klimenkova
authors.forename: E F
authors.initials: EF
authors.lastname: Malyugin
authors.forename: O S
authors.initials: OS
authors.lastname: Karchagina
authors.forename: E V
authors.initials: EV
authors.lastname: Borodulina
authors.forename: A V
authors.initials: AV
authors.lastname: Turenko
mesh_terms: D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests / Q000379:methods*; D001809:Blood Viscosity / Q000502:physiology*; D004903:Erythrocyte Aggregation / Q000502:physiology*; D005340:Fibrinogen / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D013916:Thrombelastography / Q000379:methods
chemical_list: D005340:Fibrinogen