title: Do Nonsteroidal Anti-Inflammatory Drugs Cause Endoprosthetic Loosening? Mid- to Long-Term Follow-Up of 100 Total Hip Arthroplasties after Local NSAID Infiltration.
abstract: We evaluated the effect of local infiltration of NSAIDs on prosthetic fixation at mid- to long-term follow-up of total hip arthroplasties. Intra-articular local NSAID (ketorolac) was injected into hip joints and surrounding tissues intraoperatively and postoperatively as a part of multimodal pain management protocol. Clinical and radiographic evaluation was performed for any evidence of component loosening or failure and clinical outcomes in 100 total hip joint arthroplasties with a mean follow-up of 7.3 years (4.9 to 11 yrs). Radiographic analysis at the most recent follow-up showed no evidence of loosening, subsidence, or migration and no evidence of impending failure. Clinical outcomes showed improved Harris hip scores. Intra-articular NSAID used in the intraoperative/postoperative period in hip arthroplasty showed no evidence of prosthetic loosening at mid- to long-term follow-up.
authors.affiliation: Joint Orthopaedic Centre, P.O. Box 240, Bondi Junction, NSW 1335, Australia.
authors.forename: Ikram
authors.initials: I
authors.lastname: Nizam
authors.affiliation: Joint Orthopaedic Centre, P.O. Box 240, Bondi Junction, NSW 1335, Australia.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Kohan
authors.affiliation: Joint Orthopaedic Centre, P.O. Box 240, Bondi Junction, NSW 1335, Australia.
authors.forename: Clarice
authors.initials: C
authors.lastname: Field
authors.affiliation: Joint Orthopaedic Centre, P.O. Box 240, Bondi Junction, NSW 1335, Australia.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kerr
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal