title: Recent advances in renal transplantation: antibody-mediated rejection takes center stage.
abstract: Overlooked for decades, antibodies have taken center stage in renal transplantation and are now widely recognized as the first cause of allograft failure. Diagnosis of antibody-mediated rejection has considerably improved with identification of antibody-mediated lesions in graft biopsies and advances made in the detection of circulating donor-specific antibodies. Unfortunately, this progress has not yet translated into better outcomes for patients. Indeed, in the absence of a drug able to suppress antibody generation by plasma cells, available therapies can only slow down graft destruction. This review provides an overview of the current knowledge of antibody-mediated rejection and discusses future interesting research directions.
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Eric
authors.initials: E
authors.lastname: Pouliquen
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Alice
authors.initials: A
authors.lastname: Koenig
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Chien Chia
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Antoine
authors.initials: A
authors.lastname: Sicard
authors.affiliation: Laboratoire d'anatomopathologie, Hospices Civils de Lyon, Hôpital Edouard HerriotLyonFrance.
authors.forename: Maud
authors.initials: M
authors.lastname: Rabeyrin
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon
authors.affiliation: Laboratoire d'Histocompatibilité, Etablissement Français du SangLyonFrance.
authors.forename: Valérie
authors.initials: V
authors.lastname: Dubois
authors.affiliation: Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Transplantation, Néphrologie et Immunologie CliniqueLyonFrance.|Institut National de la Santé et de la Recherche MédicaleU1111, LyonFrance.|Unité de Formation et de Recherche Lyon Est, Université de LyonLyonFrance.
authors.forename: Olivier
authors.initials: O
authors.lastname: Thaunat