title: Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy.
abstract: Today, nanotechnology plays a vital role in biomedical applications, especially for the diagnosis and treatment of various diseases. Among the many different types of fabricated nanoparticles, magnetic metal oxide nanoparticles stand out as unique and useful tools for biomedical applications, because of their imaging characteristics and therapeutic properties such as drug and gene carriers. Polymer-coated magnetic particles are currently of particular interest to investigators in the fields of nanobiomedicine and fundamental biomaterials. Theranostic magnetic nanoparticles that are encapsulated or coated with polymers not only exhibit imaging properties in response to stimuli, but also can efficiently deliver various drugs and therapeutic genes. Even though a large number of polymer-coated magnetic nanoparticles have been fabricated over the last decade, most of these have only been used for imaging purposes. The focus of this review is on polysaccharide-coated magnetic nanoparticles used for imaging and gene delivery.
authors.affiliation: Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Saji
authors.initials: S
authors.lastname: Uthaman
authors.affiliation: Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Sang Joon
authors.identifier: 0000-0002-7337-0243
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Kondareddy
authors.initials: K
authors.lastname: Cherukula
authors.affiliation: Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Republic of Korea.
authors.forename: Chong-Su
authors.initials: CS
authors.lastname: Cho
authors.affiliation: Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D058185:Magnetite Nanoparticles / Q000627:therapeutic use*; D036103:Nanotechnology; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use; D011134:Polysaccharides / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D058185:Magnetite Nanoparticles; D011108:Polymers; D011134:Polysaccharides