title: Incidence of dementia and subtypes: A cohort study in four regions in China.
abstract: BACKGROUND
  There is a dearth of literature on the incidence of dementia in China.
  
  
  METHODS
  Using a stratified, multistage, cluster-sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers in China in 1997 and followed up to 4.5 years. Cases were identified through a three-step protocol, according to standardized criteria for dementia, Alzheimer's dementia (AD), and vascular dementia (VaD).
  
  
  RESULTS
  The crude incidence in persons ≥65 years was 12.1/1000 person-years for dementia, 8.2/1000 person-years for AD, and 3.1/1000 person-years for VaD. After adjusting for sociodemographic factors, older age and lower education were associated with a higher risk of incident dementia, AD and VaD; regional difference was associated mainly with incidence of VaD (north vs. south: hazard ratio [HR] = 3.59); modestly with AD (east vs. west: HR = 1.55).
  
  
  CONCLUSIONS
  The incidence of dementia in Chinese population is comparable with that in Europe and United States.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Electronic address: wuzhangzhenxin@163.com.
authors.forename: Zhenxin
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Wen
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hong
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
authors.forename: Qiumin
authors.initials: Q
authors.lastname: Qu
authors.affiliation: Department of Psychiatry, The First Hospital, Huaxi Medical College, Chengdu, People's Republic of China.
authors.forename: Mouni
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Neurology, Beijing Sixth Hospital, Beijing, People's Republic of China.
authors.forename: Jixing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Epidemiology and Biostatistics, Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Cummings
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003704:Dementia / Q000145:classification* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D017678:Sex Distribution
keywords: Alzheimer's disease; China; Dementia; Epidemiology; Incidence; Prospective cohort study; Risk factors; Vascular dementia