title: Three-Dimensional Optoacoustic and Laser-Induced Ultrasound Tomography System for Preclinical Research in Mice: Design and Phantom Validation.
abstract: In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents.
authors.affiliation: TomoWave Laboratories, Houston, TX, USA sae@tomowave.com.
authors.forename: S A
authors.initials: SA
authors.lastname: Ermilov
authors.affiliation: TomoWave Laboratories, Houston, TX, USA Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
authors.forename: R
authors.initials: R
authors.lastname: Su
authors.affiliation: TomoWave Laboratories, Houston, TX, USA.
authors.forename: A
authors.initials: A
authors.lastname: Conjusteau
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
authors.forename: F
authors.initials: F
authors.lastname: Anis
authors.affiliation: TomoWave Laboratories, Houston, TX, USA.
authors.forename: V
authors.initials: V
authors.lastname: Nadvoretskiy
authors.affiliation: Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Anastasio
authors.affiliation: TomoWave Laboratories, Houston, TX, USA Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Oraevsky
mesh_terms: D000818:Animals; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007834:Lasers; D051379:Mice; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D015203:Reproducibility of Results; D014054:Tomography / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods
keywords: mouse imaging; photoacoustic tomography; speed of sound tomography