title: Construction of an all-carbon quaternary stereocenter by organocatalytic enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron deficient vinylarenes.
abstract: A chiral amine catalyzed enantioselective α-functionalization of α-substituted β-ketocarbonyls with electron-deficient vinylarenes has been developed to construct the dicarbonyl products with the formation of a chiral all-carbon quaternary stereocenter. The products can be used for the efficient synthesis of useful but challenging chiral quaternary centered pyrazolones.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, and State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China. hli77@ecust.edu.cn.
authors.forename: Shizhou
authors.initials: S
authors.lastname: Liu
authors.forename: Mengchao
authors.initials: M
authors.lastname: Tong
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Hexin
authors.initials: H
authors.lastname: Xie
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D007659:Ketones; D014753:Vinyl Compounds; D002244:Carbon