title: Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores.
abstract: BACKGROUND
  Acne vulgaris is one of the most common skin diseases treated by dermatologists. Salts of copper chlorophyllin complex are semi-synthetic naturally-derived compounds with antioxidant, anti-inflammatory and wound healing activity that have not been previously tested topically in the treatment of acne-prone skin with enlarged pores.
  
  
  OBJECTIVE
  This single-center pilot study was conducted to assess the efficacy and safety of a liposomal dispersion of topically applied sodium copper chlorophyllin complex in subjects with mild-moderate acne and large, visible pores over a course of 3 weeks.
  
  
  METHODS
  Subjects were supplied with the test product, a topical gel containing a liposomal dispersion of sodium copper chlorophyllin complex (0.1%) with directions to apply a small amount to the facial area twice daily. Clinical assessments were performed at screening/baseline and at week 3. VISIA readings were taken and self-assessment questionnaires were conducted.
  
  
  RESULTS
  10 subjects were enrolled and completed the 3-week study. All clinical efficacy parameters showed statistically significant improvements over baseline at week 3. The study product was well tolerated. Subject questionnaires showed the test product was highly rated.
  
  
  CONCLUSIONS
  In this pilot study, a topical formulation containing a liposomal dispersion of sodium copper chlorophyllin complex was shown to be clinically effective and well tolerated for the treatment of mild-moderate acne and large, visible pores when used for 3 weeks.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Stephens
authors.forename: John P
authors.initials: JP
authors.lastname: McCook
authors.forename: James H
authors.initials: JH
authors.lastname: Herndon
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002735:Chlorophyllides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005145:Face; D005782:Gels / Q000008:administration & dosage; D006801:Humans; D010865:Pilot Projects; D012867:Skin / Q000473:pathology; D055815:Young Adult
chemical_list: D002735:Chlorophyllides; D003879:Dermatologic Agents; D005782:Gels; C007020:chlorophyllin