title: Multifunctional 3D Patternable Drug-Embedded Nanocarrier-Based Interfaces to Enhance Signal Recording and Reduce Neuron Degeneration in Neural Implantation.
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, 30010, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Huang
authors.affiliation: Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, No. 268, Kaixuan Road, Hangzhou City, Zhejiang Province, 310029, China.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Lai
authors.affiliation: Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. Keyan Road, Miaoli, 35053, Taiwan.
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Kuo
authors.affiliation: Department of Medical Research, Buddhist Tzu Chi General Hospital, No. 707, Sec. 3, Chung-Yang Rd., Hualien, 97002, Taiwan.
authors.forename: Chia-Hsin
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, 30010, Taiwan.
authors.forename: Po-Hsieh
authors.initials: PH
authors.lastname: Chang
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, 30010, Taiwan.
authors.forename: Ta-Chung
authors.initials: TC
authors.lastname: Liu
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, No. 1001, Ta-Hsueh Rd., Hsinchu, 30010, Taiwan.
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, National Yang Ming University, No. 155, Sec. 2, Linong St., Taipei, 11221, Taiwan.
authors.forename: You-Yin
authors.initials: YY
authors.lastname: Chen
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D055119:Elastic Modulus; D055724:Electrophysiological Phenomena; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry* / Q000633:toxicity; D009410:Nerve Degeneration / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*; D016716:PC12 Cells; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D059629:Signal-To-Noise Ratio; D013718:Tensile Strength
chemical_list: D004337:Drug Carriers; D017382:Reactive Oxygen Species; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011100:Polyglycolic Acid; D019344:Lactic Acid
keywords: drug delivery; hydrogel; nanocarrier(s); neural implant; neural interface