title: Recombinant MAG1 Protein of Toxoplasma gondii as a Diagnostic Antigen.
abstract: The aim of this study was to evaluate the potential diagnostic usefulness of the full-length recombinant Toxoplasma gondii MAG1 protein by determining the levels of specific IgM and IgG antibodies in mouse and human sera obtained from individuals with acute and chronic toxoplasmosis. The obtained results revealed that IgG antibodies against MAG1 are a sensitive and specific marker of T. gondii infection since the protein was recognized by both mouse and human sera, 100% and 94.3%, respectively, rendering the full-length rMAG1 a prospective alternative for the polyvalent native antigen (TLA).
authors.forename: Justyna M
authors.initials: JM
authors.lastname: Gatkowska
authors.forename: Bożena
authors.initials: B
authors.lastname: Dziadek
authors.forename: Jarosław
authors.initials: J
authors.lastname: Dziadek
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Dzitko
authors.forename: Henryka
authors.initials: H
authors.lastname: Długońska
mesh_terms: D000818:Animals; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D007075:Immunoglobulin M / Q000097:blood / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism; D014123:Toxoplasmosis / Q000097:blood / Q000175:diagnosis / Q000469:parasitology*; D014124:Toxoplasmosis, Animal / Q000097:blood / Q000175:diagnosis / Q000469:parasitology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015800:Protozoan Proteins; D011994:Recombinant Proteins