title: [Skin disorder as an indication of viral infection].
abstract: BACKGROUND
  Gianotti-Crosti syndrome (GCS) is a dermatosis primarily affecting children between 2 and 6 years of age. It is characterized by multiple, itching, monomorphous, pink to red-brown papules or papulovesicles between 1 and 5 mm in size. GCS is associated with viral infections such as hepatitis B virus and Epstein-Barr virus (EBV). It is often accompanied by fever, hepatosplenomegaly and lymphadenopathy. The syndrome is self-limiting and disappears within 2 months. No treatment is therefore required.
  
  
  METHODS
  We report a case of a 16-year-old female who presented with itching papulovesicles on the extremities and on the buttocks. She was diagnosed with GCS because of the clinical findings, histopathological tests and positive EBV serology.
  
  
  CONCLUSIONS
  GCS can also affect patients older than 6 years of age. Moreover, this syndrome may be a first sign of infection with Epstein-Barr virus, hepatitis B virus, HIV or other viral infections.
authors.affiliation: Sint Franciscus Gasthuis, Rotterdam.
authors.forename: Sanne M
authors.initials: SM
authors.lastname: Snelder
authors.forename: Lotte K
authors.initials: LK
authors.lastname: Engels
authors.forename: Hans
authors.initials: H
authors.lastname: van der Valk
authors.forename: Marinus C G
authors.initials: MC
authors.lastname: van Praag
mesh_terms: D000169:Acrodermatitis / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D000293:Adolescent; D002081:Buttocks / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis*; D005121:Extremities / Q000473:pathology; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000821:virology; D011537:Pruritus / Q000175:diagnosis / Q000821:virology