title: Olanzapine-Induced Reversible Pellagroid Skin Lesion.
abstract: Adverse cutaneous reactions are frequently reported to occur with the use of psychotropic medications, which may lead to poor drug compliance. As compared to other groups of psychotropic medication, antipsychotics, both typical and atypical, are less likely to cause adverse cutaneous reactions. The most frequent cutaneous adverse reactions associated with antipsychotics include fixed drug eruptions, exanthematous eruptions, photosensitivity reactions and altered skin pigmentation. Most of these commonly seen cutaneous adverse reactions are benign and easily treatable. Rarely, severe cutaneous adverse reactions such as erythema multiforme, Steven-Johnson syndrome are toxic epidermal necrolysis and have also been associated with antipsychotics. Olanzapine is one of the most commonly prescribed atypical antipsychotic with metabolic complications as most common adverse effects. Dermatological reactions are rarely observed with olanzapine. We report occurrence of pellagroid skin lesions over exposed areas of upper limbs with olanzapine that resolved completely after its discontinuation.
authors.forename: Lokesh K
authors.initials: LK
authors.lastname: Singh
authors.forename: Manoj
authors.initials: M
authors.lastname: Sahu
authors.affiliation: Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, 576104, India. samirpsyche@yahoo.co.in.
authors.forename: Samir K
authors.initials: SK
authors.lastname: Praharaj
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D057915:Drug Substitution; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D000077152:Olanzapine; D000069348:Quetiapine Fumarate / Q000627:therapeutic use; D012074:Remission Induction; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012880:Skin Pigmentation / Q000187:drug effects*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D000077152:Olanzapine