title: Serum periostin is associated with prevalent knee osteoarthritis and disease incidence/progression in women: the OFELY study.
abstract: OBJECTIVE
  Our aim was to investigate the relationships between serum periostin (POSTN) and both prevalence and incidence/progression of knee osteoarthritis (OA) in women.
  
  
  METHODS
  We investigated 594 women (62.7 ± 11.2 yr) from the OFELY cohort. Knee radiographs were scored according to the Kellgren & Lawrence (KL) grading system at baseline and 4 years later. Spine, hip and hand OA were assessed at baseline. Prevalent knee OA was defined by a KL score higher or equal in 2. Progression of KL was defined as an increase of the KL score ≥1 during the 4 years follow-up. Serum POSTN was measured at baseline by ELISA.
  
  
  RESULTS
  By non-parametric tests, POSTN was significantly lower in 83 women with a KL score ≥2 at baseline, compared to those with a KL score <2 (n = 511; 1101 ± 300 vs 1181 ± 294 ng/ml, P = 0.002) after adjustment for age, body mass index (BMI), treatments and diseases, prevalent hand OA and prevalent lumbar spine OA. By logistic regression analyses, the odds-ratio of knee OA incidence/progression was significantly reduced by 21% (P = 0.043) for each quartile increase in serum POSTN at baseline, after adjustment for age, BMI, prevalent knee OA, prevalent hand OA and prevalent lumbar spine OA.
  
  
  CONCLUSIONS
  We show for the first time that serum POSTN is associated with prevalence and the risk of development/progression of knee OA in women.
authors.affiliation: INSERM Research Unit 1033, Université de Lyon, 69437 Lyon Cedex 03, France. Electronic address: jean-charles.rousseau@inserm.fr.
authors.forename: J C
authors.initials: JC
authors.lastname: Rousseau
authors.affiliation: INSERM Research Unit 1033, Université de Lyon, 69437 Lyon Cedex 03, France; Service de rhumatologie et pathologie osseuse, Hôpital E.-Herriot, Université de Lyon, 69437 Lyon Cedex 03, France. Electronic address: elisabeth.rendu@inserm.fr.
authors.forename: E
authors.initials: E
authors.lastname: Sornay-Rendu
authors.affiliation: INSERM Research Unit 1033, Université de Lyon, 69437 Lyon Cedex 03, France. Electronic address: cindy.bertholon@inserm.fr.
authors.forename: C
authors.initials: C
authors.lastname: Bertholon
authors.affiliation: INSERM Research Unit 1033, Université de Lyon, 69437 Lyon Cedex 03, France; Cisbio Bioassays, Codolet, France; Service de rhumatologie et pathologie osseuse, Hôpital E.-Herriot, Université de Lyon, 69437 Lyon Cedex 03, France. Electronic address: patrickgarnero@free.fr.
authors.forename: P
authors.initials: P
authors.lastname: Garnero
authors.affiliation: INSERM Research Unit 1033, Université de Lyon, 69437 Lyon Cedex 03, France; Service de rhumatologie et pathologie osseuse, Hôpital E.-Herriot, Université de Lyon, 69437 Lyon Cedex 03, France. Electronic address: roland.chapurlat@inserm.fr.
authors.forename: R
authors.initials: R
authors.lastname: Chapurlat
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015815:Cell Adhesion Molecules / Q000097:blood*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D050823:Hand Joints / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D015207:Osteoarthritis, Hip / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D055013:Osteoarthritis, Spine / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Incidence/progression; Knee; Osteoarthritis; Periostin; Prevalence