title: Effect of electron radiation on vasomotor function of the left anterior descending coronary artery.
abstract: The left anterior descending (LAD, interventricular) coronary artery provides the blood supply to the mid-region of the heart and is a major site of vessel stenosis. Changes in LAD function can have major effects on heart function. In this report, we examined the effect of electron simulated solar particle event (eSPE) radiation on LAD function in a porcine animal model. Vasodilatory responses to adenosine diphosphate (ADP; 10(−9)–10(−4) M), bradykinin (BK; 10(−11)–10(−6) M), and sodium nitroprusside (SNP; 10(−10)–10(−4) M) were assessed. The LAD arteries from Control (non-irradiated) and the eSPE (irradiated) animals were isolated and exhibited a similar relaxation response following treatment with either ADP or SNP. In contrast, a significantly reduced relaxation response to BK treatment was observed in the eSPE irradiated group, compared to the control group. These data demonstrate that simulated SPE radiation exposure alters LAD function.
authors.forename: Jenine K
authors.initials: JK
authors.lastname: Sanzari
authors.forename: Paul C
authors.initials: PC
authors.lastname: Billings
authors.forename: Jolaine M
authors.initials: JM
authors.lastname: Wilson
authors.forename: Eric S
authors.initials: ES
authors.lastname: Diffenderfer
authors.forename: Arturo A
authors.initials: AA
authors.lastname: Arce-Esquivel
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Thorne
authors.forename: Maurice H
authors.initials: MH
authors.lastname: Laughlin
authors.forename: Ann R
authors.initials: AR
authors.lastname: Kennedy
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D003331:Coronary Vessels / Q000528:radiation effects*; D004583:Electrons / Q000009:adverse effects; D006321:Heart / Q000528:radiation effects*; D008297:Male; D009599:Nitroprusside / Q000494:pharmacology*; D013552:Swine; D013556:Swine, Miniature; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D000244:Adenosine Diphosphate; D001920:Bradykinin