title: A numerical model of blood oxygenation during veno-venous ECMO: analysis of the interplay between blood oxygenation and its delivery parameters.
abstract: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an important tool in the management of most severe forms of acute respiratory failure. The determinants and management of oxygen delivery in patients treated with VV-ECMO is a complex topic. The physiological principles of oxygenation on VV-ECMO are reviewed in many textbooks. However a numerical model is an additional instrument to be used in understanding and exploring this intricate subject matter. We present a numerical model of blood oxygenation during VV-ECMO. Using this model we examined the role and impact of each determinant on blood oxygenation. The numerical analysis of variation and interplay between each oxygenation determinants during VV-ECMO is presented in graphical form. These results corroborate all the findings of previous studies. The proposed numerical model facilitates understanding of oxygenation physiology during VV-ECMO; it can be used for a medical simulation system and for teaching the principles of oxygenation during VV-ECMO.
authors.affiliation: Service de réanimation, Centre Hospitalier de Cholet, 1 rue Marengo, BP 507, 49325, Cholet, France. messaielmi@gmail.com.
authors.forename: Elmi
authors.initials: E
authors.lastname: Messai
authors.affiliation: Departement de Physique, Université de Souk-Ahras, 41000, Souk-Ahras, Algeria.
authors.forename: Abdesselam
authors.initials: A
authors.lastname: Bouguerra
authors.affiliation: Cardiac Surgery, Department of Sperimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: Guy
authors.initials: G
authors.lastname: Harmelin
authors.affiliation: Cardiac Surgery, Department of Sperimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Di Lascio
authors.affiliation: Anaesthesia and Intensive Care Unit of Emergency Department, Careggi Teaching Hospital, Florence, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Bonizzoli
authors.affiliation: Cardiac Surgery, Department of Sperimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonacchi
mesh_terms: D002302:Cardiac Output / Q000502:physiology; D003198:Computer Simulation; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods / Q000706:statistics & numerical data; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008955:Models, Cardiovascular; D010100:Oxygen / Q000097:blood*; D013318:Stroke Volume / Q000502:physiology
chemical_list: D006454:Hemoglobins; D010100:Oxygen
keywords: ARDS; ECMO; Numerical modelling; Oxygenation; Recirculation; Simulation