title: Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo.
abstract: BACKGROUND
  The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis.
  
  
  METHODS
  Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression.
  
  
  RESULTS
  Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found.
  
  
  CONCLUSIONS
  Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.
authors.affiliation: Department of Dermatology and Venereology, Tanta University, Tanta, Egypt - lamia_elgarhy@yahoo.com.
authors.forename: Lamia H
authors.initials: LH
authors.lastname: Elgarhy
authors.forename: Amani
authors.initials: A
authors.lastname: Abdullatif
authors.forename: Rehab
authors.initials: R
authors.lastname: Abdelazim
authors.forename: Karima I
authors.initials: KI
authors.lastname: El-Desouky
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000379:methods; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000235:genetics*; D000070819:Discoidin Domain Receptor 1 / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008544:Melanocytes / Q000378:metabolism*; D008875:Middle Aged; D014820:Vitiligo / Q000235:genetics / Q000473:pathology*; D055815:Young Adult
chemical_list: D000070819:Discoidin Domain Receptor 1