title: Association between vitamin D receptor polymorphisms and haplotypes with pulmonary tuberculosis.
abstract: The vitamin D receptor (VDR) is an important factor in activating immune response in different infectious diseases. The aim of the present study was to investigate the association between theVDRgene polymorphisms and pulmonary tuberculosis (PTB). The case control study was performed on 120 PTB patients and 131 healthy controls. Genetic analysis was performed by polymerase chain reaction and the restriction fragment length polymorphism method. TheVDR Fok1 Ffgenotype was associated with TB and the risk of PTB was two times higher in individuals with theFfgenotype. A higher frequency offallele was observed in PTB patients and therefore, thefallele may be a risk factor for PTB susceptibility. There were no associations between theTaq1andBsm1polymorphisms and PTB. In addition, haplotype analysis showed that thef-T-Bandf-t-bhaplotypes (Fok1, Taq1andBsm1) may have the potential to increase PTB susceptibility. In conclusion, theFfgenotype andfallele of theVDR Fok1polymorphism were associated with PTB susceptibility. In addition, thef-T-Bandf-t-bhaplotypes may be the susceptible haplotypes for PTB.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Departments of Clinical Biochemistry and Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Salimi
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Departments of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Farajian-Mashhadi
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Alavi-Naini
authors.affiliation: Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Golbarg
authors.initials: G
authors.lastname: Talebian
authors.affiliation: Department of Genetics, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Narooie-Nejad
keywords: gene; haplotype; polymorphism; pulmonary tuberculosis; vitamin D receptor