title: GABAB Agonists for the Treatment of Alcohol Use Disorder.
abstract: Almost 10% of the world's population is affected by alcohol use disorder (AUD). The combination between psychosocial intervention and pharmacological treatment seems to be the most effective approach for patients affected by AUD. Among effective drugs useful in the treatment of AUD, GABAB-ergic medications have been tested with encouraging results (i.e. sodium oxybate, baclofen, gabapentin, pregabalin and tiagabine). The present review will summarize available data on these medications.
authors.forename: Antonio
authors.initials: A
authors.lastname: Mirijello
authors.forename: Fabio
authors.initials: F
authors.lastname: Caputo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Vassallo
authors.forename: Benjamin
authors.initials: B
authors.lastname: Rolland
authors.forename: Claudia
authors.initials: C
authors.lastname: Tarli
authors.forename: Antonio
authors.initials: A
authors.lastname: Gasbarrini
authors.affiliation: Department of Internal Medicine, Catholic University of Rome, Gemelli Hospital, Largo Gemelli 8, 00168 Rome, Italy. g.addolorato@rm.unicatt.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Addolorato
mesh_terms: D019973:Alcohol-Related Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D058786:GABA-B Receptor Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D057970:Inappropriate Prescribing; D056687:Off-Label Use; D061214:Patient Safety; D010818:Practice Patterns, Physicians'; D018080:Receptors, GABA-B / Q000187:drug effects* / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D058786:GABA-B Receptor Agonists; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid