title: [Experience of using interferon Β-1a biosimilans (cinnovex and genfaxon-44) in the Moscow Multiple Sclerosis Center].
abstract: OBJECTIVE
  To study the efficacy and tolerability of generics (interferon beta-1a biosimilans) cinnovex for intramascular introduction and genfaxon-44 for subcutaneous injections in multiple sclerosis (MS).
  
  
  METHODS
  One hundred patients were treated with cinnovex and 104 patients were treated with genfaxon-44 during one year. Patient's status was assessed using clinical approach, psychometric scales and MRI.
  
  
  CONCLUSIONS
  The high percentage of withdrawal of treatment due to the lack of clinical effect and intolerance to the drugs was identified during the treatment. Positive effect with respect to stabilization of MS course was found only in patients who earlier did not receive disease-modifying drugs. Double-blind studies are needed to resolve the question of the adequacy of brand-name drugs and generics.
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow.
authors.forename: O G
authors.initials: OG
authors.lastname: Borets
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Davydovskaya
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: T L
authors.initials: TL
authors.lastname: Demina
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Lashch
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: N F
authors.initials: NF
authors.lastname: Popova
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Popova
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Khachanova
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Khasayeva
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow.
authors.forename: S G
authors.initials: SG
authors.lastname: Shchur
authors.affiliation: Moscow Multiple Sclerosis Center of the City Hospital #24, Moscow; Pirogov Russian National Research Medical University, Moscow.
authors.forename: A N
authors.initials: AN
authors.lastname: Boyko