title: Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis.
abstract: The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio- and enantioselective addition of active borylcopper(I) species to indole-2-carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers.
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita-ku, Sapporo, Hokkaido 060-8628 (Japan).
authors.forename: Koji
authors.initials: K
authors.lastname: Kubota
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita-ku, Sapporo, Hokkaido 060-8628 (Japan).
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hayama
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita-ku, Sapporo, Hokkaido 060-8628 (Japan).
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Iwamoto
authors.affiliation: Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University, Kita 13 Nishi 8 Kita-ku, Sapporo, Hokkaido 060-8628 (Japan). hajito@eng.hokudai.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Ito
keywords: borylation; copper; dearomatization; enantioselective synthesis; indoles