title: Autotransplantation of cryopreserved ovarian tissue after treatment for malignant disease - the first Norwegian results.
abstract: BACKGROUND
  With increasing survival rates after treatment for cancer in prepubertal girls and women of reproductive age, an increasing focus on quality of life has emerged. Both irradiation and cytotoxic drugs can be detrimental to future fertility, consequently several treatment alternatives have been developed to spare or restore fertility in young females diagnosed with cancer. One of these options is cryopreservation of ovarian tissue before treatment and autotransplantation at a later time.
  
  
  METHODS
  We present the Norwegian experience after 11 years of practice with ovarian tissue cryopreservation. A total of 164 patients have had ovarian tissue cryopreserved during the period 2004-2014. Fifteen patients died during the observation period. Six patients requested autotransplantation, which was performed in two women.
  
  
  RESULTS
  Both patients conceived, one spontaneously and one after assisted reproduction due to a concomitant male factor. The pregnancies were uneventful and they each gave birth to a healthy child.
  
  
  CONCLUSIONS
  Cryopreservation with later autotransplantation of ovarian tissue should be offered to a selected group of young women with cancer.
authors.affiliation: Department of Gynecology, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Tanbo
authors.affiliation: Department of Gynecology, Oslo University Hospital, Oslo, Norway.
authors.forename: Gareth
authors.initials: G
authors.lastname: Greggains
authors.affiliation: Norwegian National Advisory Unit on Women's Health, Oslo University Hospital, Oslo, Norway.
authors.forename: Ritsa
authors.initials: R
authors.lastname: Storeng
authors.affiliation: Department of Gynecology, Oslo University Hospital, Oslo, Norway.
authors.forename: Bjørn
authors.initials: B
authors.lastname: Busund
authors.affiliation: Department of Gynecology, Oslo University Hospital, Oslo, Norway.
authors.forename: Anton
authors.initials: A
authors.lastname: Langebrekke
authors.affiliation: Department of Gynecology, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Peter
authors.initials: P
authors.lastname: Fedorcsak
mesh_terms: D000328:Adult; D015925:Cryopreservation; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D009664:Norway; D010052:Ovariectomy; D010053:Ovary / Q000637:transplantation*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011788:Quality of Life; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D055815:Young Adult
keywords: Autotransplantation; cancer; chemotherapy; cryopreservation; fertility; ovary