title: Cutaneous Phaeohyphomycosis Caused by Exophiala attenuata in a Domestic Cat.
abstract: A 7-year-old female-spayed, domestic short-haired cat was presented to her veterinarian with a mass on the hind paw. Histopathologic examination of a tissue biopsy revealed nodular pyogranulomatous panniculitis with intralesional pigmented fungal hyphae. A dematiaceous fungal isolate was isolated with a micromorphological phenotype consistent with the anamorphic genus Exophiala: budding cells, torulose mycelium and annellidic conidiogenesis from simple conidiophores consisting of terminal and lateral cells that tapered to a short beak at the apex. Sequence homology of the internal transcribed spacer region of the rDNA gene confirmed the identification of the isolate as Exophiala attenuata. Reported here is the first confirmed case of feline phaeohyphomycosis caused by E. attenuata in North America. Similar to historical cases of feline phaeohyphomycosis caused by Exophiala spp., there was no history or postmortem evidence to suggest the patient was in an immunocompromised state (e.g., suffering from FeLV or FIV). Although aggressive surgical excision of local lesions is recommended prior to drug treatment when dealing with subcutaneous phaeohyphomycosis, surgery followed by itraconazole treatment did not resolve the E. attenuata infection in this cat.
authors.affiliation: Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, C1A 4P3, Canada, dovery@upei.ca.
authors.forename: David P
authors.initials: DP
authors.lastname: Overy
authors.forename: Chelsea
authors.initials: C
authors.lastname: Martin
authors.forename: Anne
authors.initials: A
authors.lastname: Muckle
authors.forename: Lorraine
authors.initials: L
authors.lastname: Lund
authors.forename: Jill
authors.initials: J
authors.lastname: Wood
authors.forename: Paul
authors.initials: P
authors.lastname: Hanna
mesh_terms: D000818:Animals; D001706:Biopsy; D002371:Cat Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D002415:Cats; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005093:Exophiala / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006614:Hindlimb / Q000473:pathology; D006651:Histocytochemistry; D008853:Microscopy; D008969:Molecular Sequence Data; D009656:North America; D060446:Phaeohyphomycosis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D010802:Phylogeny; D010860:Pigments, Biological / Q000032:analysis; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D010860:Pigments, Biological