title: WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm.
abstract: We report a 50-year-old woman with no relevant clinical history who presented with headache and loss of memory. Magnetic resonance imaging showed a left parieto-temporal mass with annular enhancement after contrast media administration, rendering a radiological diagnosis of high-grade astrocytic neoplasm. Tumour sampling was performed but the patient ultimately died as a result of disease. Microscopically, the lesion had areas of glioblastoma mixed with a benign mesenchymal constituent; the former showed hypercellularity, endothelial proliferation, high mitotic activity and necrosis, while the latter showed fascicles of long spindle cells surrounded by collagen and reticulin fibers. With approximately 40 previously reported cases, gliofibroma is a rare neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As shown in our case, its prognosis is apparently determined by the degree of anaplasia of the glial component.
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Paola A
authors.initials: PA
authors.lastname: Escalante Abril
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Miguel Fdo
authors.initials: MF
authors.lastname: Salazar
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Nubia L
authors.initials: NL
authors.lastname: López García
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Mónica N
authors.initials: MN
authors.lastname: Madrazo Moya
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Yadir U
authors.initials: YU
authors.lastname: Zamora Guerra
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Yadira Gandhi
authors.initials: YG
authors.lastname: Mata Mendoza
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Erick
authors.initials: E
authors.lastname: Gómez Apo
authors.affiliation: Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico.
authors.forename: Laura G
authors.initials: LG
authors.lastname: Chávez Macías
keywords: Adult population; Bimorphic neoplasm; Desmoplastic glioma; Gliofibroma; Tumour suppressor protein 53