title: Depression, anxiety and non-motor symptoms on initiation of intrajejunal levodopa/carbidopa therapy.
abstract: In Parkinson's disease (PD), clinical observations and some studies suggest that depression and anxiety are linked to motor fluctuations. We studied prospectively 10 patients with advanced PD just before initiation of intrajejunal levodopa/carbidopa therapy, and after 1 and 3 months of regular treatment. Motor symptoms, motor fluctuations, non-motor symptoms, quality of sleep, symptoms of depression and anxiety were evaluated with the appropriate scales. As expected, motor symptoms and motor fluctuations improved considerably. Non-motor symptoms, quality of sleep and depression also improved significantly. However, anxiety score remained unchanged during the study. Our data in a small numbers of patients indicate that all aspects of mental and psychic symptoms are not alleviated within a short period of reduction of motor fluctuations.
authors.affiliation: Department of Neurology, Hôpital Erasme, Bruxelles, Belgium. fbellant@ulb.ac.be.
authors.forename: F
authors.initials: F
authors.lastname: Bellante
authors.affiliation: Department of Neurology, Hôpital de Tivoli, La Louvière, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Dethy
authors.affiliation: Department of Neurology, Hôpital Erasme, Bruxelles, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Zegers de Beyl
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects*; D001007:Anxiety / Q000139:chemically induced*; D002230:Carbidopa / Q000009:adverse effects*; D003863:Depression / Q000139:chemically induced*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007583:Jejunum / Q000187:drug effects / Q000502:physiology; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa
keywords: Depression and Anxiety; Non-motor symptoms; Parkinson’s disease