title: Synthetic applications of hypophosphite derivatives in reduction.
abstract: The development of new tools for the reduction of organic functions to reach high chemo- and stereo-selectivity is an important research domain. Although, aluminum and boron hydrides are commonly used, they suffer from environmentally and safety issues. In particular, at industrial scale, the search for more specific and efficient reagents with a lower ecological impact remains one of the main objectives of organic chemists. This review captures highlights from literature concerning phosphonic and phosphinic acid derivatives as reducing agents and evaluates their potential as alternatives, in particular to boron and aluminum hydrides.
authors.affiliation: Equipe Catalyse Synthèse Environnement, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Université de Lyon, Université Claude Bernard-Lyon 1, Bâtiment Curien, 43 boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France. estelle.metay@univ-lyon1.fr.
authors.forename: Carole
authors.initials: C
authors.lastname: Guyon
authors.forename: Estelle
authors.initials: E
authors.lastname: Métay
authors.forename: Florence
authors.initials: F
authors.lastname: Popowycz
authors.forename: Marc
authors.initials: M
authors.lastname: Lemaire
mesh_terms: D002384:Catalysis; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010721:Phosphinic Acids / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry
chemical_list: D010721:Phosphinic Acids; D010758:Phosphorus; D010100:Oxygen