title: An Open Label, Phase 2 Study of MABp1 Monotherapy for the Treatment of Acne Vulgaris and Psychiatric Comorbidity.
abstract: BACKGROUND
  Acne vulgaris is a common inflammatory skin disorder. There remain few rapid, safe, and effective therapy options for patients with moderate to severe acne vulgaris that also address psychological comorbidities such as anxiety.
  
  
  OBJECTIVE
  To assess the efficacy of interleukin 1 alpha blockade in patients with moderate to severe acne vulgaris using the true human monoclonal antibody MABp1.
  
  
  METHODS
  Eleven patients were administered open-label, subcutaneous injections of MABp1 over a six-week period. Objectives were assessment of safety, change in inflammatory lesion count and change in psychosocial functioning using two validated questionnaires.
  
  
  RESULTS
  There were no serious adverse events, or adverse events greater than grade I. Median inflammatory lesion counts decreased 36% (IQR -44% to 1%). Anxiety scores improved (from median 6 to 1) as well as self-image assessment (2.3±0.9 to 2.1±0.1) as measured by the Hospital Anxiety and Depression Scale and the modified Body Image Disturbance Questionnaire.
  
  
  CONCLUSIONS
  Patients had rapid improvement of skin lesions, as well as psychosocial functioning and anxiety. MABp1 may provide a safe and effective means for treating inflammatory acne lesions and. Further studies using this antibody are warranted in this patient population.
authors.forename: Daniel
authors.initials: D
authors.lastname: Carrasco
authors.forename: Michael
authors.initials: M
authors.lastname: Stecher
authors.forename: Gigi Claire
authors.initials: GC
authors.lastname: Lefebvre
authors.forename: Alan C
authors.initials: AC
authors.lastname: Logan
authors.forename: Ronald
authors.initials: R
authors.lastname: Moy
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000523:psychology; D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001007:Anxiety / Q000209:etiology; D001828:Body Image / Q000523:psychology; D003863:Depression / Q000209:etiology; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000066498:Emotional Adjustment; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D053582:Interleukin-1alpha / Q000037:antagonists & inhibitors; D008297:Male; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D003879:Dermatologic Agents; D053582:Interleukin-1alpha; C000599944:MABp1 monoclonal antibody