title: Synthesis ofN-substituted aryl amidines by strong base activation of amines.
abstract: We describe an efficient method for the direct preparation ofN-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines.
authors.affiliation: Department of Chemistry & Biochemistry, University of Oregon, Eugene, OR 97403-1253, USA.
authors.forename: Muhammad M
authors.initials: MM
authors.lastname: Khalifa
authors.affiliation: Department of Chemistry & Biochemistry, University of Oregon, Eugene, OR 97403-1253, USA.
authors.forename: Micah J
authors.initials: MJ
authors.lastname: Bodner
authors.affiliation: Department of Chemistry & Biochemistry, University of Oregon, Eugene, OR 97403-1253, USA ; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Berglund
authors.affiliation: Department of Chemistry & Biochemistry, University of Oregon, Eugene, OR 97403-1253, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Haley
keywords: Amidine; amine; base-activation; nitrile; strong base