title: Effect of Nasal Corticosteroid on Secretory Immunoglobulin A Measured in Rat Nasal Lavage: Experimental Study.
abstract: OBJECTIVE
  In this study, we aimed to experimentally investigate the effects of nasal corticosteroids on the levels of secretory immunoglobulin A (sIgA) in nasal mucosa in rats.
  
  
  METHODS
  Prospective, randomized control trial.
  
  
  METHODS
  Research laboratory.
  
  
  METHODS
  Twenty-four male Sprague Dawley rats were included in our study. The rats were randomized into 3 groups. In group 1, nasal mometasone furoate was applied to the rats for 30 days. Saline was applied to group 2 for 30 days. Group 3 was the control group and received no treatment throughout the study period. Nasal lavage was conducted on both nasal openings of all rats in the 3 groups at the beginning of the study and on days 15 and 30, and the lavage solution (distilled water) was collected by aspiration.
  
  
  RESULTS
  In group 1, the sIgA value was significantly higher at day 15 than at baseline. No significant difference was found between the sIgA values on day 15 and day 30. In groups 2 and 3, there were no significant differences in sIgA values at baseline, day 15, and day 30. The sIgA value of group 1 on day 15 was significantly higher than the values of groups 2 and 3. The sIgA value of group 1 on day 30 was significantly higher than the values of groups 2 and 3.
  
  
  CONCLUSIONS
  Topical corticosteroids (mometasone furoate) applied to the nasal mucosa significantly increase nasal sIgA levels.
authors.affiliation: Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.
authors.forename: Fadlullah
authors.initials: F
authors.lastname: Aksoy
authors.affiliation: Bayrampasa State Hospital, Department of Otorhinolaryngology, Bayrampasa, Istanbul, Turkey dr.remzidogan@gmail.com.
authors.forename: Remzi
authors.initials: R
authors.lastname: Dogan
authors.affiliation: Koç University, Department of Otorhinolaryngology, Sarıyer, Istanbul, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Kocak
authors.affiliation: Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.
authors.forename: Bayram
authors.initials: B
authors.lastname: Veyseller
authors.affiliation: Bezmialem Vakif University, Department of Otorhinolaryngology, Fatih, Istanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozturan
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine Department of Biochemistry, Fatih, Istanbul, Turkey.
authors.forename: Said
authors.initials: S
authors.lastname: Incir
mesh_terms: D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000818:Animals; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008297:Male; D000068656:Mometasone Furoate; D055556:Nasal Lavage; D011244:Pregnadienediols / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000305:Adrenal Cortex Hormones; D007071:Immunoglobulin A, Secretory; D011244:Pregnadienediols; D000068656:Mometasone Furoate
keywords: mometasone furoate; nasal lavage; rat; secretory immunoglobulin A