title: Common RASGRP1 Gene Variants That Confer Risk of Type 2 Diabetes.
abstract: BACKGROUND
  Genome-wide association studies have validated the RAS guanyl nucleotide-releasing protein 1 (RASGRP1) gene as a type 2 diabetes (T2D) susceptibility locus.
  
  
  OBJECTIVE
  This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.
  
  
  METHODS
  Eleven common variants of RASGRP1 were detected using TaqMan technology in 1272 healthy controls and 1234 T2D patients. All study participants were unrelated members of the Han ethnic group in China. In this study, the rs7403531 genotype frequency differed significantly between T2D patients and controls (allele: adjusted p=8.30×10(-6), genotype: adjusted p=2.50×10(-5), OR=1.366 [95% CI=1.206-1.546]). The rs4465567-rs4567661 C-A and C-C haplotypes were also significant risk factors for T2D (adjusted p=0.0002 and p=0.0006, respectively) with a global p-value of 6.46×10(-5). These results indicate that in a Chinese Han population, RASGRP1 variants, particularly rs7403531, confer a risk for developing T2D.
authors.affiliation: 1 Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai, China .
authors.forename: Jun-Yan
authors.initials: JY
authors.lastname: Li
authors.affiliation: 1 Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai, China .
authors.forename: Feng
authors.initials: F
authors.lastname: Tao
authors.affiliation: 2 Shanghai Technical Institute of Electronics & Information , Shanghai, China .
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Wu
authors.affiliation: 1 Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai, China .
authors.forename: Ying-Zi
authors.initials: YZ
authors.lastname: Tan
authors.affiliation: 3 Bio-X Institutes, Shanghai Jiao Tong University , Shanghai, China .
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.affiliation: 1 Diabetes Research Institute, Department of Endocrinology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine , Shanghai, China .
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; C491790:RASGRP1 protein, human