title: The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.
abstract: A fundamental goal of research into the basic mechanisms of aging is to develop translational strategies that improve human health by delaying the onset and progression of age-related pathology. Several interventions have been discovered that increase life span in invertebrate organisms, some of which have similar effects in mice. These include dietary restriction and inhibition of the mechanistic target of rapamycin by treatment with rapamycin. Key challenges moving forward will be to assess the extent to which these and other interventions improve healthy longevity and increase life span in mice and to develop practical strategies for extending this work to the clinic. Companion animals may provide an optimal intermediate between laboratory models and humans. By improving healthy longevity in companion animals, important insights will be gained regarding human aging while improving the quality of life for people and their pets.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA, USA kaeber@uw.edu.
authors.forename: M
authors.initials: M
authors.lastname: Kaeberlein
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D059232:Laboratory Personnel; D008136:Longevity; D051379:Mice; D023421:Models, Animal; D057805:Pets / Q000502:physiology*; D011788:Quality of Life; D012106:Research
keywords: caloric restriction; dietary restriction; dogs; health span; life span; mechanistic target of rapamycin; mice; sirtuins; target of rapamycin