title: Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing?
abstract: After diagnosis of non-functioning pituitary adenoma and impact assessment (pituitary deficiency, visual field disorder), the question of management arises between surgery and surveillance. This part of the Consensus document aims to clarify the principal situations encountered in clinical practice (visual disorder, pituitary deficiency, asymptomatic adenoma, etc.), so as to determine which ones indicate surgery and which ones simple surveillance. Particular contexts are also dealt with (elderly patients, young women hoping for pregnancy, etc). The principal surgical techniques (microscopy, endoscopy, etc.) are also considered. Finally, in case of surgery, the principal pathologic criteria are specified (immunolabeling, proliferation markers, etc.).
authors.affiliation: Service d'endocrinologie, hôpital de la Timone, Aix-Marseille université, AP-HM, 13000 Marseille, France. Electronic address: Frederic.castinetti@ap-hm.fr.
authors.forename: Frederic
authors.initials: F
authors.lastname: Castinetti
authors.affiliation: Service de neurochirurgie, hôpital de la Timone, Aix-Marseille université, AP-HM, 13000 Marseille, France.
authors.forename: Henry
authors.initials: H
authors.lastname: Dufour
authors.affiliation: Service de neurochirurgie, hôpital Foch, 75016 Paris, France.
authors.forename: Stephane
authors.initials: S
authors.lastname: Gaillard
authors.affiliation: Service de neurochirurgie, hospices civils de Lyon, groupement hospitalier Est, 69495 Lyon, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Jouanneau
authors.affiliation: Centre de pathologie Est, hospices civils de Lyon, groupement hospitalier Est, 69495 Lyon, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasiljevic
authors.affiliation: Departement d'anatomo-pathologie et cytologie, hôpital Foch, 92151 Suresnes, France; Inserm unité 1016, Institut Cochin, université Paris-Descartes, 75014 Paris, France; Departement d'endocrinologie, université de Liège, CHU de Liège, domaine universitaire du Sart-Tilman, 4000 Liège, Belgium.
authors.forename: Chiara
authors.initials: C
authors.lastname: Villa
authors.affiliation: Centre de pathologie Est, hospices civils de Lyon, groupement hospitalier Est, 69495 Lyon, France; Departement d'anatomo-pathologie et cytologie, hôpital Foch, 92151 Suresnes, France; Inserm unité 1016, Institut Cochin, université Paris-Descartes, 75014 Paris, France; Departement d'endocrinologie, université de Liège, CHU de Liège, domaine universitaire du Sart-Tilman, 4000 Liège, Belgium; Laboratoire d'histologie et d'embryologie moléculaires, faculté de médecine Lyon-Est, 69495 Lyon, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Trouillas
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D000066491:Clinical Decision-Making; D032921:Consensus; D006801:Humans; D009493:Neurosurgery; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D014786:Vision Disorders / Q000209:etiology
keywords: Adénome hypophysaire; Adénome hypophysaire silencieux; Anomalie du champ visuel; Déficit hypophysaire; Elderly subject; Grossesse; Ki67; Pituitary adenoma; Pituitary deficiency; Pregnancy; Silent pituitary adenoma; Sujet âgé; Visual field defect; p53