title: Screening Mild and Major Neurocognitive Disorders in Parkinson's Disease.
abstract: BACKGROUND
  Among the nonmotor features of Parkinson's disease (PD), cognitive impairment is one of the most troublesome problems. New diagnostic criteria for mild and major neurocognitive disorder (NCD) in PD were established by Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5). The aim of our study was to establish the diagnostic accuracy of widely used screening tests for NCD in PD.
  
  
  METHODS
  Within the scope of our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke's Cognitive Examination (ACE), Mattis Dementia Rating Scale (MDRS), Mini Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA)) in 370 PD patients without depression.
  
  
  RESULTS
  MoCA and ACE feature the finest diagnostic accuracy for detecting mild cognitive disorder in PD (DSM-5) at the cut-off scores of 23.5 and 83.5 points, respectively. The diagnostic accuracy of these tests was 0.859 (95% CI: 0.818-0.894, MoCA) and 0.820 (95% CI: 0.774-0.859, ACE). In the detection of major NCD (DSM-5), MoCA and MDRS tests exhibited the best diagnostic accuracy at the cut-off scores of 20.5 and 132.5 points, respectively. The diagnostic accuracy of these tests was 0.863 (95% CI: 0.823-0.897, MoCA) and 0.830 (95% CI: 0.785-0.869, MDRS).
  
  
  CONCLUSIONS
  Our study demonstrated that the MoCA may be the most suitable test for detecting mild and major NCD in PD.
authors.affiliation: Institute of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti Utca 12, Pécs 7624, Hungary.
authors.forename: Tivadar
authors.initials: T
authors.lastname: Lucza
authors.affiliation: Institute of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti Utca 12, Pécs 7624, Hungary.
authors.forename: Kázmér
authors.initials: K
authors.lastname: Karádi
authors.affiliation: Institute of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti Utca 12, Pécs 7624, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Kállai
authors.affiliation: Institute of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti Utca 12, Pécs 7624, Hungary.
authors.forename: Rita
authors.initials: R
authors.lastname: Weintraut
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Pécs, Rét Utca 2, Pécs 7623, Hungary ; MTA-PTE Clinical Neuroimaging MR Research Group, Pécs, Rét Utca 23, Pécs 7623, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Janszky
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Makkos
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Pécs, Rét Utca 2, Pécs 7623, Hungary.
authors.forename: Sámuel
authors.initials: S
authors.lastname: Komoly
authors.affiliation: Department of Neurology, Faculty of Medicine, University of Pécs, Rét Utca 2, Pécs 7623, Hungary ; MTA-PTE Clinical Neuroimaging MR Research Group, Pécs, Rét Utca 23, Pécs 7623, Hungary.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kovács
mesh_terms: D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000523:psychology*; D003704:Dementia / Q000175:diagnosis*; D003863:Depression / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D011594:Psychometrics / Q000379:methods