title: Effect of dorzolamide-timolol fixed combination prophylaxis on intraocular pressure spikes after intravitreal bevacizumab injection.
abstract: OBJECTIVE
  To evaluate the effect of topical dorzolamide-timolol fixed combination prophylaxis on short term intraocular pressure (IOP) changes in patients who had intravitreal bevacizumab injection.
  
  
  METHODS
  One hundred and fifty one eyes of 151 patients which were followed up in retina clinic in Ulucanlar Eye Training and Research Hospital were evaluated in this study. Patients were divided into two groups. Group 1 consists of 75 patients who had topical dorzolamid-timolol medication two hours before injection; while Group 2 consists of 76 patients without prophylaxis. Demographic data, IOP measurements prior to the injection and one, thirty and sixty minutes and twenty-four hours after the injection were recorded. The data were analyzed using SPSS software version 15.0 (SPSS Inc., Chicago, IL, USA).
  
  
  RESULTS
  There were no significant difference between two groups in age, gender distrubition and indications for injections. The mean IOPs in Groups 1 and 2 prior to the injection (T0) were 17.84±0.43 and 18.15±0.43 mm Hg, one minute after the injection (T1) were 29.75±1.6 and 34.44±1.59 mm Hg, 30min after the injection (T30) were 20.06±0.6 and 21.71±0.59 mm Hg respectively. The mean IOPs were 18.26±0.56 mm Hg in Group 1 and 19.78±0.56 mm Hg in Group 2 sixty minutes after the injection (T60). All IOP values after the injection were compared between two groups, there was a significant difference between two groups only on T1; one minute after the injection (P=0.04). There were a statiscially significant difference between the baseline values and other recorded values; except on T60, in Groups 1 and 2 (P<0.05).
  
  
  CONCLUSIONS
  After intravitreal bevacizumab injection; we observe a transient IOP elevation which normalizes about one hour after intravitreal injection. In patients who had topical dorzolamid-timolol combination prophylaxis before injections, a significant decrease is seen in IOP spikes due to this injection. The appropiate approach will monitor IOP after intravitreal injection and evaluate the using prophylactic antiglaucomatous drugs before the injection in patients with ganglion nerve cell damage.
authors.affiliation: Eye Clinic, Baskale Devlet Hastanesi, Van 65600, Turkey.
authors.forename: Sehnaz
authors.initials: S
authors.lastname: Ozcaliskan
authors.affiliation: Department of Ophthalmology, Yildirim Beyazit University, Ankara 06830, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ozturk
authors.affiliation: Eye Clinic, Ulucanlar Eye Training and Research Hospital, Ankara 06230, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Yilmazbas
authors.affiliation: Department of Ophthalmology, Gynecology and Pediactric Diseases Hospital, Samsun 55060, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Beyazyildiz
keywords: bevacizumab; dorzolamid-timolol combination; intraocular pressure