title: Seroprevalence for Hepatitis E and Other Viral Hepatitides among Diverse Populations, Malawi.
abstract: Data on prevalence of hepatitis E virus (HEV) in Malawi is limited. We tested blood samples from HIV-uninfected and -infected populations of women and men enrolled in research studies in Malawi during 1989-2008 to determine the seroprevalence of HEV, hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total antibodies against HAV and HCV, and presence of HBV surface antigens. Of 800 samples tested, 16.5% were positive for HEV IgG, 99.6% were positive for HAV antibodies, 7.5% were positive for HBV surface antigen, and 7.1% were positive for HCV antibodies. No clear trends over time were observed in the seroprevalence of HEV, and HIV status was not associated with hepatitis seroprevalence. These preliminary data suggest that the seroprevalence of HEV is high in Malawi; the clinical effects may be unrecognized or routinely misclassified.
authors.forename: Taha E
authors.initials: TE
authors.lastname: Taha
authors.forename: Laura K
authors.initials: LK
authors.lastname: Rusie
authors.forename: Alain
authors.initials: A
authors.lastname: Labrique
authors.forename: Mulinda
authors.initials: M
authors.lastname: Nyirenda
authors.forename: Dean
authors.initials: D
authors.lastname: Soko
authors.forename: Melvin
authors.initials: M
authors.lastname: Kamanga
authors.forename: Johnstone
authors.initials: J
authors.lastname: Kumwenda
authors.forename: Homayoon
authors.initials: H
authors.lastname: Farazadegan
authors.forename: Kenrad
authors.initials: K
authors.lastname: Nelson
authors.forename: Newton
authors.initials: N
authors.lastname: Kumwenda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D016751:Hepatitis E / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D016752:Hepatitis E virus / Q000276:immunology; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
keywords: HAV; HBV; HCV; HEV; HIV; Hepatitis; Malawi; prevalence; viruses