title: Non-autonomous consequences of cell death and other perks of being metazoan.
abstract: Drosophila melanogasterremains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use ofDrosophilato study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights fromDrosophilawill be discussed in the context of analogous processes in mammalian development and cancer biology.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado, Boulder, CO 80309-0347, USA.
authors.forename: Tin Tin
authors.initials: TT
authors.lastname: Su
keywords: Drosophila; apoptosis; cancer; caspase; imaginal discs