title: Correlation of Microalbuminuria with Estimated GFR (eGFR) by Cockcroft-Gault and MDRD Formula in Type 2 Diabetics and Hypertensives.
abstract: Increase in urine albumin excretion rate (AER) precede a fall in glomerular filtration rate in patients developing diabetic chronic kidney disease (CKD). Our results have shown that 7 (50 %) of diabetic and hypertensive individuals with decreased GFR do not have increased AER. In this cross-sectional study, we measured AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric method. We correlated the results with eGFR values obtained by Cockcroft-Gault and MDRD method. The method used was not a compensated method. We measured serum creatinine by modified Jaffe's kinetic method in autoanalyzer XL-600. Analysis of data showed positive correlation between eGFR and microalbuminuria by both the methods with eGFR <60 mL/min/1.73 m(2). Pearson's correlation co-efficient (r) was 0.9 (p = 0.0001) by Cockcroft-Gault formula and 0.69 (p = 0.0063) by MDRD formula. Our results concluded that there was positive correlation between AER and eGFR <60 mL/min/1.73 m(2). We have recognized that these two parameters provide a complimentary benefit in management of cases with CKD.
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: T K
authors.initials: TK
authors.lastname: Saha
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: Arabinda Mohan
authors.initials: AM
authors.lastname: Bhattarai
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: H S
authors.initials: HS
authors.lastname: Batra
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: Mithu
authors.initials: M
authors.lastname: Banerjee
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: Pratibha
authors.initials: P
authors.lastname: Misra
authors.affiliation: Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India.
authors.forename: Vivek
authors.initials: V
authors.lastname: Ambade
keywords: Albumin excretion rate; Cockcroft–Gault; Modification of diet in renal disease; eGFR