title: Primary gynecologic melanoma: A report of two unusual cases.
abstract: BACKGROUND
  Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically.
  
  
  METHODS
  A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab.
  
  
  CONCLUSIONS
  Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.
authors.affiliation: Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Berger
authors.affiliation: Department of Pathology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Daman
authors.initials: D
authors.lastname: Samrao
authors.affiliation: Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Huang
authors.affiliation: Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Olawaiye
keywords: Cervical melanoma; Immunotherapy; Multidisciplinary treatment; Ovarian melanoma