title: PRP and articular cartilage: a clinical update.
abstract: The convincing background of the recent studies, investigating the different potentials of platelet-rich plasma, offers the clinician an appealing alternative for the treatment of cartilage lesions and osteoarthritis. Recent evidences in literature have shown that PRP may be helpful both as an adjuvant for surgical treatment of cartilage defects and as a therapeutic tool by intra-articular injection in patients affected by osteoarthritis. In this review, the authors introduce the trophic and anti-inflammatory properties of PRP and the different products of the available platelet concentrates. Then, in a complex scenario made of a great number of clinical variables, they resume the current literature on the PRP applications in cartilage surgery as well as the use of intra-articular PRP injections for the conservative treatment of cartilage degenerative lesions and osteoarthritis in humans, available as both case series and comparative studies. The result of this review confirms the fascinating biological role of PRP, although many aspects yet remain to be clarified and the use of PRP in a clinical setting has to be considered still exploratory.
authors.affiliation: Department of Orthopaedics and Traumatology, University of Torino, 10100 Torino, Italy ; Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.
authors.forename: Antonio
authors.identifier: 0000-0002-1683-6094
authors.initials: A
authors.lastname: Marmotti
authors.affiliation: Department of Orthopaedics and Traumatology, University of Torino, 10100 Torino, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rossi
authors.affiliation: Department of Orthopaedics and Traumatology, University of Torino, 10100 Torino, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Castoldi
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
authors.forename: Eliana
authors.identifier: 0000-0003-2092-3999
authors.initials: E
authors.lastname: Roveda
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Michielon
authors.affiliation: Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy ; IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy.
authors.forename: Giuseppe M
authors.identifier: 0000-0001-9341-7187
authors.initials: GM
authors.lastname: Peretti
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D053657:Platelet-Rich Plasma
chemical_list: D000893:Anti-Inflammatory Agents