title: Aerosolized Surfactants, Anti-Inflammatory Drugs, and Analgesics.
abstract: Drug delivery by aerosol may have several advantages over other modes, particularly if the lung is the target organ. Aerosol delivery may allow achievement of higher concentrations while minimizing systemic effects and offers convenience, rapid onset of action, and avoidance of the needles and sterile technique necessary with intravenous drug administration. Aerosol delivery may change the pharmacokinetics of many drugs, however, and an awareness of the caveats of aerosolized drug delivery is mandatory to ensure both safety and adequate drug delivery. This paper discusses the administration of surfactants, anti-inflammatory agents, and analgesics by the aerosol route.
authors.affiliation: Division of Pediatric Critical Care, Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia. dwillson@mcvh-vcu.edu.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Willson
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000700:Analgesics / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D013501:Surface-Active Agents / Q000008:administration & dosage*
chemical_list: D000336:Aerosols; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D013501:Surface-Active Agents
keywords: aerosolized surfactants; analgesics; anti-inflammatory agents; drug delivery