title: Uterine artery embolization by use of porous gelatin particles for symptomatic uterine leiomyomas: comparison with hand-cut gelatin sponge particles.
abstract: OBJECTIVE
  To evaluate the results of uterine artery embolization (UAE) for symptomatic uterine leiomyoma by use of porous gelatin particles (PGP) in comparison with conventional hand-cut gelatin sponge particles.
  
  
  METHODS
  One hundred and fifteen consecutive patients who had undergone UAE were retrospectively assessed. The first 64 patients were treated with hand-cut gelatin sponge and the last 51 with PGP. Extent of infarction, volume reduction of the dominant leiomyoma on magnetic resonance (MR) imaging, and change in symptoms were assessed.
  
  
  RESULTS
  UAE was successfully performed for all patients. No major complications were observed. MR images one month after UAE showed that the mean extent of infarction of the dominant leiomyoma was 97 % for patients treated with PGP and 96 % for those treated with hand-cut gelatin sponge. Volume reductions of the dominant leiomyoma after 3, 6, 12, and 24 months were, respectively, 45, 56, 62, and 66 % for use of PGP and 45, 57, 63, and 68 % for use of hand-cut gelatin sponge. Symptoms including heavy menstrual bleeding, heavy menstrual pain, and abdominal heaviness had improved by 95-100 % at 12 months. There was no difference between the two groups.
  
  
  CONCLUSIONS
  UAE with PGP is safe, and as effective as conventional gelatin sponge particles.
authors.affiliation: Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute City, 480-1195, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Izumi
authors.forename: Shuji
authors.initials: S
authors.lastname: Ikeda
authors.forename: Akira
authors.initials: A
authors.lastname: Kitagawa
authors.forename: Eisuke
authors.initials: E
authors.lastname: Katsuda
authors.forename: Makiyo
authors.initials: M
authors.lastname: Hagihara
authors.forename: Seiji
authors.initials: S
authors.lastname: Kamei
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Ota
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Ishiguchi
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005780:Gelatin / Q000627:therapeutic use*; D005781:Gelatin Sponge, Absorbable / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000379:methods; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000601:surgery*
chemical_list: D006490:Hemostatics; D005780:Gelatin