title: [Study on regulatory effect of Danshensu on lipid metabolism of hyperlipidemia rats].
abstract: OBJECTIVE
  To explore the effect of Danshensu on the lipid metabolism of hyperlipidemic rats.
  
  
  METHODS
  Sixty clean male SD rats were selected. Twelve of them were selected in the basic control group and fed with common foods, and the remaining rats were fed with the high-fat feeds. After the successful modeling, they were randomly divided into the high-fat control group and low dose (10 mg x kg(-1) x d(-1)), medium dose (20 mg x kg(-1) x d(-1)) and high dose (40 mg x kg(-1) x d(-1)) Danshensu (dissolved in saline) groups. Both of the two groups were abdominally injected with the same volume of normal saline once a day for consecutively 30 days. The serum TG, TC, HDL-C and liver ACC1, FAS, HMGR, CPT-I mRNA expressions were detected.
  
  
  CONCLUSIONS
  Danshensu could inhibit the LDL-C level, timely clear redundant cholesterol and effectively regulate the lipid metablism of hyperlipidemic rats by reducing the TC content, decrease the fatty acid by reducing the FAS mRNA expression, and reduce the synthesis levels of endogenous cholesterol by inhibit the HMGR mRNA expression.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Deng
authors.forename: Yu-yan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Li
authors.forename: Fei-yu
authors.initials: FY
authors.lastname: Wu
authors.forename: Hai-tong
authors.initials: HT
authors.lastname: Wan
mesh_terms: D000818:Animals; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D007773:Lactates / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid