title: Reducing Skeletal-Related Events in Metastatic Castration-Resistant Prostate Cancer.
abstract: Skeletal-related events contribute substantially to morbidity, mortality and cost in men with metastatic castration-resistant prostate cancer (mCRPC). There are five agents available for treatment in mCRPC that reduce skeletal-related events. Here we discuss the efficacy and safety of zoledronic acid, denosumab, enzalutamide, abiraterone, and radium-223. We include data on and a discussion of duration of treatment with zoledronic acid and denosumab, the only two of these agents that do not have a clinically proven anticancer effect. Finally, we review the available data regarding the cost of denosumab compared with that of zoledronic acid.
authors.forename: Julie N
authors.initials: JN
authors.lastname: Graff
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Beer
mesh_terms: D059002:Androgen Receptor Antagonists / Q000627:therapeutic use; D000736:Androstenes / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000517:prevention & control* / Q000556:secondary; D003362:Cost-Benefit Analysis; D000069448:Denosumab; D004164:Diphosphonates / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005598:Fractures, Spontaneous / Q000517:prevention & control*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008297:Male; D009570:Nitriles; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy / Q000473:pathology*; D011788:Quality of Life; D011868:Radioisotopes / Q000627:therapeutic use; D011883:Radium / Q000627:therapeutic use; D013117:Spinal Cord Compression / Q000517:prevention & control*; D000077211:Zoledronic Acid
chemical_list: D059002:Androgen Receptor Antagonists; D000736:Androstenes; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D001549:Benzamides; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D004791:Enzyme Inhibitors; D007093:Imidazoles; D009570:Nitriles; D011868:Radioisotopes; D010669:Phenylthiohydantoin; D000069448:Denosumab; D000077211:Zoledronic Acid; C540278:enzalutamide; C089740:abiraterone; D011883:Radium