title: Role of dietary polyphenols in the management of peptic ulcer.
abstract: Peptic ulcer disease is a multifactorial and complex disease involving gastric and duodenal ulcers. Despite medical advances, the management of peptic ulcer and its complications remains a challenge, with high morbidity and death rates for the disease. An accumulating body of evidence suggests that, among a broad reach of natural molecules, dietary polyphenols with multiple biological mechanisms of action play a pivotal part in the management of gastric and duodenal ulcers. The current review confirmed that dietary polyphenols possess protective and therapeutic potential in peptic ulcer mediated by: improving cytoprotection, re-epithelialization, neovascularization, and angiogenesis; up-regulating tissue growth factors and prostaglandins; down-regulating anti-angiogenic factors; enhancing endothelial nitric oxide synthase-derived NO; suppressing oxidative mucosal damage; amplifying antioxidant performance, antacid, and anti-secretory activity; increasing endogenous mucosal defensive agents; and blocking Helicobacter pylori colonization associated gastric morphological changes and gastroduodenal inflammation and ulceration. In addition, anti-inflammatory activity due to down-regulation of proinﬂammatory cytokines and cellular and intercellular adhesion agents, suppressing leukocyte-endothelium interaction, inhibiting nuclear signaling pathways of inflammatory process, and modulating intracellular transduction and transcription pathways have key roles in the anti-ulcer action of dietary polyphenols. In conclusion, administration of a signiﬁcant amount of dietary polyphenols in the human diet or as part of dietary supplementation along with conventional treatment can result in perfect security and treatment of peptic ulcer. Further well-designed preclinical and clinical tests are recommended in order to recognize higher levels of evidence for the confirmation of bioefficacy and safety of dietary polyphenols in the management of peptic ulcer.
authors.affiliation: Mohammad Hosein Farzaei, Mohammad Abdollahi, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Farzaei
authors.affiliation: Mohammad Hosein Farzaei, Mohammad Abdollahi, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.affiliation: Mohammad Hosein Farzaei, Mohammad Abdollahi, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
authors.forename: Roja
authors.initials: R
authors.lastname: Rahimi
mesh_terms: D004032:Diet; D019587:Dietary Supplements; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000178:diet therapy* / Q000209:etiology; D006801:Humans; D059808:Polyphenols / Q000008:administration & dosage*; D012307:Risk Factors; D013276:Stomach Ulcer / Q000175:diagnosis / Q000178:diet therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D059808:Polyphenols
keywords: Anti-inflammatory; Dietary supplement; Helicobacter pylori; Inflammatory cytokines; Natural medicine; Non-steroidal anti-inflammatory drugs; Peptic ulcer; Polyphenols; Ulcer healing