title: Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii.
abstract: Five polyphenols were isolated from the ethanolic extract of the fruiting bodies of Phellinus baumii. These compounds were identified by various spectroscopic methods as hispidin, hypholomine B, inoscavin A, davallialactone, and phelligridin D. All compounds inhibited noncompetitively H1N1, H5N1, and H3N2 neuraminidase activity and reduced the amount of virally-induced cytopathic effect (CPE) according to an MDCK cell-based assay.
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea.
authors.forename: Byung Soon
authors.initials: BS
authors.lastname: Hwang
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea.
authors.forename: In-Kyoung
authors.initials: IK
authors.lastname: Lee
authors.affiliation: Department of Beauty Science, Kwangju Women's University, 165 Sanjeong-dong, Gwangsan-gu, Kwangju 506-713, Republic of Korea.
authors.forename: Hwa Jung
authors.initials: HJ
authors.lastname: Choi
authors.affiliation: Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University, 79 Gobong-ro, Iksan-si 570-752, Republic of Korea. Electronic address: bsyun@jbnu.ac.kr.
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects / Q000201:enzymology; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects / Q000201:enzymology; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D061985:Madin Darby Canine Kidney Cells; D008518:Medicine, East Asian Traditional; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000201:enzymology; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D059808:Polyphenols; D009439:Neuraminidase
keywords: Anti-influenza; Cytopathic effect; Neuraminidase inhibition; Phellinus baumii; Polyphenol