title: Apple Peel Supplemented Diet Reduces Parameters of Metabolic Syndrome and Atherogenic Progression in ApoE-/- Mice.
abstract: Cardiovascular Diseases (CVD) represent about 30% of all causes of death worldwide. The development of CVD is related in many cases with the previous existence of metabolic syndrome (MS). It is known that apple consumption has a cardiovascular protecting effect, containing phenolic compounds with antioxidant effect, which are concentrated in the fruit peel. The objective of this study was to test the effect of apple peel consumption in a murine model of MS and apoE-/- mice. Apple supplemented diets reduced the biochemical parameters (glycaemia, total cholesterol, HDL-cholesterol, LDL-cholesterol, ureic nitrogen, triglycerides, insulin, and asymmetric dimethylarginine (ADMA)) of MS model in CF1 mice significantly. The model apoE-/- mouse was used to evaluate the capacity of the apple peel to revert the progression of the atherogenesis. FD with HAP reverts cholesterol significantly and slows down the progression of the plate diminishing the cholesterol accumulation area. With these results, it can be concluded that the consumption of apple peel reduces several MS parameters and the atherogenic progression in mice.
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile ; Programa de Magister en Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Chile.
authors.forename: Jaime
authors.initials: J
authors.lastname: Gonzalez
authors.affiliation: Departamento de Estomatología, Facultad de Ciencias de la Salud, Universidad de Talca, Chile ; Instituto de Química y Recursos Naturales, Universidad de Talca, Chile.
authors.forename: Wendy
authors.initials: W
authors.lastname: Donoso
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sandoval
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile.
authors.forename: María
authors.initials: M
authors.lastname: Reyes
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile.
authors.forename: Priscila
authors.initials: P
authors.lastname: Gonzalez
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile.
authors.forename: Monica
authors.initials: M
authors.lastname: Gajardo
authors.affiliation: Facultad de Medicina, Universidad Católica del Maule, Avenida San Miguel 3605, 3480112 Talca, Chile.
authors.forename: Erik
authors.initials: E
authors.lastname: Morales
authors.affiliation: Centro de Pomáceas, Facultad de Ciencias Agrarias, Universidad de Talca, Chile.
authors.forename: Amalia
authors.initials: A
authors.lastname: Neira
authors.affiliation: Instituto de Química y Recursos Naturales, Universidad de Talca, Chile.
authors.forename: Iván
authors.initials: I
authors.lastname: Razmilic
authors.affiliation: Centro de Pomáceas, Facultad de Ciencias Agrarias, Universidad de Talca, Chile ; Centro de Estudios en Alimentos Procesados (CEAP), Conicyt-Regional, Gore Maule, R09I2001, Avenida San Miguel 3425, 3480137 Talca, Chile ; Programa Investigación de Excelencia Interdisciplinario en Envejecimiento Saludable PIEI-ES, Universidad de Talca, Avenida Lircay s/n, Talca, Chile.
authors.forename: José A
authors.initials: JA
authors.lastname: Yuri
authors.affiliation: Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud, Universidad de Talca, P.O. Box 747, Talca, Chile ; Centro de Estudios en Alimentos Procesados (CEAP), Conicyt-Regional, Gore Maule, R09I2001, Avenida San Miguel 3425, 3480137 Talca, Chile ; Programa Investigación de Excelencia Interdisciplinario en Envejecimiento Saludable PIEI-ES, Universidad de Talca, Avenida Lircay s/n, Talca, Chile.
authors.forename: Rodrigo
authors.identifier: 0000-0003-4870-9660
authors.initials: R
authors.lastname: Moore-Carrasco