title: [Efficacy of conservative treatment in patients with dry form of age-related macular degeneration].
abstract: OBJECTIVE
  To evaluate the efficacy of conservative treatment in dry AMD patients by means of 3D computer-automated threshold Amsler grid testing (3D-CTAG; Fink & Sadun, 2004).
  
  
  METHODS
  The study included 90 patients (180 eyes) with dry AMD divided into three groups. Group 1 (n = 30) was prescribed Vitrum Vision forte, 1 tablet b.i.d., group 2 (n = 30)--Vitrum Vision forte, 1 tablet b.i.d. and Vitrum Cardio Omega-3, 1 capsule b.i.d. Group 3 (n = 30), the controls, received Taurine 250 mg, 1 tablet b.i.d. Besides standard ophthalmic examination, all patients underwent 3D-CTAG before and after the treatment. The number of defects per eye (ND) and volume lost relative to the hill-of-vision (VLRH) were chosen as evaluation criteria.
  
  
  RESULTS
  After 3 months of treatment ND decreased from 0.33 ± 0.02 to 0.22 ± 0.01 in group 1 (p < 0.01) and from 0.33 ± 0.02 to 0.2 ± 0.01 in group 2 (p < 0.01); VLRH decreased from 0.32 ± 0.02% to 0.15 ± 0.01% out of 693,000 [deg2%] in group 1 (p < 0.01) and from 0.32 ± 0.03% to 0.15 ± 0.01% out of 693,000 [deg2%] in group 2 (p < 0.01). In the controls both indices increased: ND from 0.32 ± 0.02 to 0.37 ± 0.02 and VLRH from 0.35 ± 0.24% to 0.49 ± 0.03% out of 693,000 [deg2%] (p < 0.01).
  
  
  CONCLUSIONS
  The positive effect of Vitrum Vision forte in combination with Vitrum Cardio Omega-3 on macular function is comparable to that of monotherapy with Vitrum Vision forte. The maximum effect was achieved in patients with small scotomas (VLRH < 1.5% out of 693,000 [deg2%]).
authors.affiliation: Voronezh State Medical Academy named after N.N. Burdenko, 10 Studencheskaya St., Voronezh, Russian Federation, 394000.
authors.forename: M A
authors.initials: MA
authors.lastname: Kovalevskaya
authors.affiliation: Voronezh State Medical Academy named after N.N. Burdenko, 10 Studencheskaya St., Voronezh, Russian Federation, 394000; Voronezh State Polyclinic No. 7, 1 Pisatelya Marshaka St., Voronezh, Russian Federation, 394000.
authors.forename: S O
authors.initials: SO
authors.lastname: Milyutkina
mesh_terms: D000368:Aged; D003941:Diagnostic Techniques, Ophthalmological; D004338:Drug Combinations; D016903:Drug Monitoring / Q000379:methods; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D014975:Lutein / Q000008:administration & dosage*; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D012607:Scotoma / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D014131:Trace Elements / Q000008:administration & dosage*; D016896:Treatment Outcome; D014792:Visual Acuity; D014815:Vitamins / Q000008:administration & dosage*; D065146:Zeaxanthins / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D015525:Fatty Acids, Omega-3; D014131:Trace Elements; D014815:Vitamins; D065146:Zeaxanthins; D014975:Lutein