title: Chikungunya virus vaccines: Current strategies and prospects for developing plant-made vaccines.
abstract: Chikungunya virus is an emerging pathogen initially found in East Africa and currently spread into the Indian Ocean Islands, many regions of South East Asia, and in the Americas. No licensed vaccines against this eminent pathogen are available and thus intensive research in this field is a priority. This review presents the current scenario on the developments of Chikungunya virus vaccines and identifies the use of genetic engineered plants to develop attractive vaccines. The possible avenues to develop plant-made vaccines with distinct antigenic designs and expression modalities are identified and discussed considering current trends in the field.
authors.affiliation: Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí 78210, SLP, Mexico.
authors.forename: Jorge A
authors.initials: JA
authors.lastname: Salazar-González
authors.affiliation: Grupo de Inmunología y Vacunología, Centro de Investigaciones Biológicas del Noroeste, SC., Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, B.C.S., C.P. 23096 Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Angulo
authors.affiliation: Laboratorio de Biofarmacéuticos Recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava 6, San Luis Potosí 78210, SLP, Mexico. Electronic address: rosales.s@fcq.uaslp.mx.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
mesh_terms: D000349:Africa / Q000453:epidemiology; D000569:Americas / Q000453:epidemiology; D001210:Asia, Southeastern / Q000453:epidemiology; D065632:Chikungunya Fever / Q000453:epidemiology / Q000517:prevention & control*; D002646:Chikungunya virus / Q000276:immunology*; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D007195:Indian Ocean Islands / Q000453:epidemiology; D030821:Plants, Genetically Modified; D022462:Vaccines, Edible / Q000276:immunology / Q000302:isolation & purification; D014614:Vaccines, Synthetic / Q000276:immunology / Q000302:isolation & purification; D058425:Vaccines, Virus-Like Particle / Q000276:immunology / Q000302:isolation & purification; D014765:Viral Vaccines / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D022462:Vaccines, Edible; D014614:Vaccines, Synthetic; D058425:Vaccines, Virus-Like Particle; D014765:Viral Vaccines
keywords: E antigen; Edible crop; Oral vaccine; Transgenic plant; Transient expression; Transplastomic plant; Vaccine cost; Virus like particles