title: Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.
abstract: This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
authors.forename: Sakib
authors.initials: S
authors.lastname: Mahmud
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
authors.forename: Samina
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
authors.forename: Md Atiar
authors.initials: MA
authors.lastname: Rahman
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
authors.forename: Jannatul
authors.initials: J
authors.lastname: Aklima
authors.affiliation: Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh.
authors.forename: Shaheen
authors.initials: S
authors.lastname: Akhter
authors.affiliation: Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh.
authors.forename: Syeeda Rayhana
authors.initials: SR
authors.lastname: Merry
authors.affiliation: Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh.
authors.forename: S M Rakibul
authors.initials: SM
authors.lastname: Jubair
authors.affiliation: Department of Pharmacy, BGC Trust University, Chittagong 4000, Bangladesh.
authors.forename: Raju
authors.initials: R
authors.lastname: Dash
authors.affiliation: Department of Pharmacy, BGC Trust University, Chittagong 4000, Bangladesh.
authors.forename: Talha Bin
authors.initials: TB
authors.lastname: Emran