title: Herpes Viral Origin of the Parsonage-Turner Syndrome: Highlighting of Serological Immune Anti-Herpes Deficiency Cured by Anti-Herpes Therapy.
abstract: In 2012, a 50 year-old athletic male presented with weakness, pain and unilateral phrenic paralysis, followed by bilateral phrenic paralysis with deep dyspnea. In 2013, the Parsonage-Turner syndrome was diagnosed. When the patient was seen in September 2014 for the first time, he was facing phrenic neuromuscular failure, which led to the hypothesis of neurotropic herpes viruses. A control of the global serological anti-Herpes immunity to analyze his antibody (Ab) levels confirmed herpes immune genetic deficiency. An appropriate herpes chemotherapy treatment was proposed. Immediately, a spectacular recovery of the patient was observed, and after a few weeks, the respiratory function tests showed normal values. The hypothesis of the inductive role of viruses of the herpes family in the Parsonage-Turner syndrome was thus substantiated. The patient's immune deficiency covers the HSV2, HHV3, HHV4, HHV5 and HHV6 Ab levels. This led to the control of herpes in the family lineage: indeed, his daughter presented alterations of her serological herpes Ab levels.
authors.affiliation: Department of Tropical Diseases, Hôpital Cochin C.H.U., University Paris V, Paris.
authors.forename: Jacqueline Le
authors.initials: JL
authors.lastname: Goaster
authors.affiliation: Department of Tropical Diseases, Hôpital Cochin C.H.U., University Paris V, Paris.
authors.forename: Patrice
authors.initials: P
authors.lastname: Bourée
authors.affiliation: Biomnis Laboratory, Ivry-sur-Seine, Pasteur Institute, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Ifergan
authors.affiliation: Viral Genomics and Vaccinations, CNRS, Pasteur Institute, Paris, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Tangy
authors.affiliation: European Cancer and Environment Research Institute, Brussels, Belgium.
authors.forename: René
authors.initials: R
authors.lastname: Olivier
authors.affiliation: Jacques Monod Institute, CNRS, University of Paris VII, Paris, France.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Haenni
keywords: Appropriate anti-herpes therapy; Bilateral phrenic paralysis; Neuralgic amyotrophy; Neurotropic herpes virus occurrences; Parsonage-Turner syndrome