title: Cooperation for Better Inhibiting.
abstract: Cladosporin is an antimalarial drug that acts as an ATP-mimetic to selectively inhibit Plasmodium lysyl-tRNA synthetase. Using multiple crystal structures, Fang et al. (2015) reveal in this issue of Chemistry & Biology the fascinating mechanism responsible for cladosporin selectivity.
authors.affiliation: Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA; The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: enovoa@mit.edu.
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Novoa
authors.affiliation: Institute for Research in Biomedicine (IRB), c/Baldiri Reixac 15-21, 08028 Barcelona, Catalonia, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Catalonia, Spain. Electronic address: lluis.ribas@irbbarcelona.org.
authors.forename: Lluís
authors.initials: L
authors.lastname: Ribas de Pouplana
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D006801:Humans
chemical_list: D000255:Adenosine Triphosphate; D000604:Amino Acyl-tRNA Synthetases