title: Searching and Navigating UniProt Databases.
abstract: The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt Web site receives ∼400,000 unique visitors per month and is the primary means to access UniProt. It provides ten searchable datasets and three main tools. The key UniProt datasets are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), the UniProt Archive (UniParc), and protein sets for completely sequenced genomes (Proteomes). Other supporting datasets include information about proteins that is present in UniProtKB protein entries such as literature citations, taxonomy, and subcellular locations, among others. This paper focuses on how to use UniProt datasets. The basic protocol describes navigation and searching mechanisms for the UniProt datasets, while two alternative protocols build on the basic protocol to describe advanced search and query building.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
authors.forename: Sangya
authors.initials: S
authors.lastname: Pundir
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
authors.forename: Michele
authors.initials: M
authors.lastname: Magrane
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Martin
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.
authors.forename: Claire
authors.initials: C
authors.lastname: O'Donovan
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom.|Swiss Institute of Bioinformatics, Geneva, Switzerland.|Protein Information Resource, Washington D.C.
mesh_terms: D000595:Amino Acid Sequence; D030562:Databases, Protein; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry; D057386:Search Engine; D012984:Software
chemical_list: D011506:Proteins
keywords: UniProt; navigation; search; tutorial