title: [Impact of glutamine, eicosapntemacnioc acid, branched-chain amino acid supplements on nutritional status and treatment compliance of esophageal cancer patients on concurrent chemoradiotherapy and gastric cancer patients on chemotherapy].
abstract: OBJECTIVE
  To explore the effects of glutamine, eicosapntemacnioc acid (EPA) and branched-chain amino acids supplements in esophageal cancer patients on concurrent chemoradiotherapy and gastric cancer patients on chemotherapy.
  
  
  METHODS
  From April 2013 to April 2014, a total of 104 esophageal and gastric carcinoma patients on chemotherapy or concurrent chemoradiotherapy were recruited and randomly divided into experimental and control groups. Both groups received dietary counseling and routine nutritional supports while only experimental group received supplements of glutamine (20 g/d), EPA (3.3 g/d) and branched-chain amino acids (8 g/d). And body compositions, blood indicators, incidence of complications and completion rates of therapy were compared between two groups.
  
  
  RESULTS
  After treatment, free fat mass and muscle weight increased significantly in experiment group while decreased in control group (P < 0.05). And albumin, red blood cell count, white blood cell count and blood platelet count remained stable in experiment group while declined significantly in control group. During treatment, compared to control group, the incidences of infection-associated complication were lower (6% vs 19%, P < 0.05) and the completion rates of therapy were significantly higher in experiment group (96% vs 83%, P < 0.05).
  
  
  CONCLUSIONS
  Supplements of glutamine, EPA and branched-chain amino acids can help maintain nutrition status, decrease the complications and improve compliance for esophageal cancer patients on concurrent chemo-radiotherapy and gastric cancer patients on postoperative adjuvant chemotherapy.
authors.affiliation: Department of General Medicine, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Minghua
authors.initials: M
authors.lastname: Cong
authors.forename: Chenxin
authors.initials: C
authors.lastname: Song
authors.forename: Baohua
authors.initials: B
authors.lastname: Zou
authors.forename: Yingbing
authors.initials: Y
authors.lastname: Deng
authors.forename: Shuluan
authors.initials: S
authors.lastname: Li
authors.forename: Xuehui
authors.initials: X
authors.lastname: Liu
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
authors.forename: Jinying
authors.initials: J
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.affiliation: Email: xubinghe@medmail.com.cn.
authors.forename: Binghe
authors.initials: B
authors.lastname: Xu
mesh_terms: D000597:Amino Acids, Branched-Chain; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D019587:Dietary Supplements; D004938:Esophageal Neoplasms; D005973:Glutamine; D006801:Humans; D009752:Nutritional Status; D018529:Nutritional Support; D010349:Patient Compliance; D013274:Stomach Neoplasms
chemical_list: D000597:Amino Acids, Branched-Chain; D005973:Glutamine