title: Pericoterpenoid A, a new bioactive cadinane-type sesquiterpene from Periconia sp.
abstract: Pericoterpenoid A (1), a new cadinane-type sesquiterpene, was isolated from an endolichenic fungal strain Periconia sp. (No. 19-4-2-1). Its structure was characterized by analyzing the spectroscopic data (IR, MS, 1D- and 2D-NMR). The antimicrobial activity against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Candida albicans was evaluated. Pericoterpenoid A showed moderate antimicrobial activity against A. niger and weak activity against C. albicans. This is the first report of the presence of cadinane-type sesquiterpene in Periconia sp.
authors.affiliation: a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Wu
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Hu
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.forename: Yun-Yang
authors.initials: YY
authors.lastname: Lian
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C508039:cadinane; C000602157:pericoterpenoid A
keywords: Periconia sp; antimicrobial activity; cadinane-type sesquiterpene; endolichenic fungus; pericoterpenoid A