title: Structural Features and Asymmetric Environment of i-Pr-SPRIX Ligand.
abstract: Novel chiral diisopropyl spiro bis(isoxazoline) ligands, anti-i-Pr-SPRIX and syn-i-Pr-SPRIX, were designed and synthesized. Their catalytic utility, X-ray crystallographic analyses, and complexation studies demonstrated the structural features of tetraisopropyl spiro bis(isoxazoline) ligand, i-Pr-SPRIX, which is a prominent ligand in various enantioselective Pd catalytic processes: All i-Pr groups work in collaboration to create an effective asymmetric environment.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka, Japan.
authors.forename: Xianjin
authors.initials: X
authors.lastname: Lin
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takizawa
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai
mesh_terms: D018360:Crystallography, X-Ray; D007555:Isoxazoles / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D007555:Isoxazoles; D008024:Ligands
keywords: asymmetric environment; chiral ligand; enantioselective catalysis; isoxazoline; oxidative cyclization; palladium; spiro framework