title: Current Antiarrhythmic Therapy for Nonvalvular Atrial Fibrillation in Spain. Data From the FANTASIIA Registry.
abstract: OBJECTIVE
  Recently, there have been many developments in the management of nonvalvular atrial fibrillation, antiarrhythmic and anticoagulant therapy, and nonpharmacological treatment, but these developments are not applied immediately in clinical practice. The aim of this study was to identify the overall management and antiarrhythmic therapy used in the current general population of patients with nonvalvular atrial fibrillation in Spain.
  
  
  METHODS
  A prospective, observational study of 1318 consecutive anticoagulated patients with nonvalvular atrial fibrillation, recruited between June 2013 and March 2014. We analyzed the patients' general characteristics, management, and antiarrhythmic therapy.
  
  
  RESULTS
  Mean age was 73.8 ± 9.4 years; 42.5% were women. Atrial fibrillation was paroxysmal in 28% of the patients, permanent in 50%, persistent in 17.6%, long-standing persistent in 4.5%, and new-onset in 66 patients (5%). A rhythm control strategy was chosen in 39.4% of the patients and rate control in 60.6%. Beta-blockers were prescribed in 60.2% of the patients, digoxin in 19.5%, and calcium channel antagonists in 10.7%. The antiarrhythmic agents used were amiodarone (12.6%), flecainide (8.9%), propafenone (0.4%), sotalol (0.5%), and dronedarone (2.3%). Cardioversion had been performed previously in 41.9% of the patients, ablation in 3.4%, and atrial appendage closure in 0.2%.
  
  
  CONCLUSIONS
  Currently, patients with nonvalvular atrial fibrillation in Spain are managed mainly with rate control, and beta-blockers in particular. They receive few antiarrhythmic agents and only a very small number of these patients undergo nonpharmacological treatments.
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain. Electronic address: iroldanra@gmail.com.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Roldán Rabadán
authors.affiliation: Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Anguita Sánchez
authors.affiliation: Servicio de Cardiología, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: María Angustias
authors.initials: MA
authors.lastname: Quesada
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Camacho Siles
authors.affiliation: Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Peinado
authors.affiliation: Servicio de Cardiología, Hospital Universitario de San Juan, San Juan de Alicante, Alicante, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.affiliation: Servicio de Cardiología, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Cequier Fillat
authors.affiliation: Centro de Investigación Cardiovascular, CSIC-ICCC, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.
authors.forename: Lina
authors.initials: L
authors.lastname: Badimón
authors.affiliation: Instituto Universitario de Ciencias de la Salud, Universidad de A Coruña, A Coruña, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Muñiz
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000628:therapy*; D004554:Electric Countershock / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D009017:Morbidity / Q000639:trends; D011446:Prospective Studies; D012042:Registries; D013030:Spain / Q000453:epidemiology
chemical_list: D000889:Anti-Arrhythmia Agents
keywords: Ablación; Ablation; Antiarrhythmic therapy; Cardioversion; Cardioversión; FANTASIIA registry; Fibrilación auricular no valvular; Nonvalvular atrial fibrillation; Registro FANTASIIA; Tratamiento antiarrítmico