title: How Inflammation Impinges on NAFLD: A Role for Kupffer Cells.
abstract: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
authors.affiliation: CEDOC, NOVA Medical School, Faculdade de Ciências Médicas (NMS/FCM), Universidade Nova de Lisboa, Edifício CEDOC II, Rua Câmara Pestana, Nos. 6, 6A, 6B, Laboratory 3.8, Piso 3, 1150-082 Lisboa, Portugal ; Instituto Gulbenkian de Ciência (IGC), Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
authors.forename: Nádia
authors.initials: N
authors.lastname: Duarte
authors.affiliation: CEDOC, NOVA Medical School, Faculdade de Ciências Médicas (NMS/FCM), Universidade Nova de Lisboa, Edifício CEDOC II, Rua Câmara Pestana, Nos. 6, 6A, 6B, Laboratory 3.8, Piso 3, 1150-082 Lisboa, Portugal ; Instituto Gulbenkian de Ciência (IGC), Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
authors.forename: Inês C
authors.initials: IC
authors.lastname: Coelho
authors.affiliation: CEDOC, NOVA Medical School, Faculdade de Ciências Médicas (NMS/FCM), Universidade Nova de Lisboa, Edifício CEDOC II, Rua Câmara Pestana, Nos. 6, 6A, 6B, Laboratory 3.8, Piso 3, 1150-082 Lisboa, Portugal ; Instituto Gulbenkian de Ciência (IGC), Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
authors.forename: Rita S
authors.initials: RS
authors.lastname: Patarrão
authors.affiliation: Instituto Gulbenkian de Ciência (IGC), Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.
authors.forename: Joana I
authors.initials: JI
authors.lastname: Almeida
authors.affiliation: Instituto Gulbenkian de Ciência (IGC), Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal ; APDP-ERC Portuguese Diabetes Association Education and Research Center, Rua do Salitre, No. 118-120, 1250-203 Lisbon, Portugal.
authors.forename: Carlos
authors.initials: C
authors.lastname: Penha-Gonçalves
authors.affiliation: CEDOC, NOVA Medical School, Faculdade de Ciências Médicas (NMS/FCM), Universidade Nova de Lisboa, Edifício CEDOC II, Rua Câmara Pestana, Nos. 6, 6A, 6B, Laboratory 3.8, Piso 3, 1150-082 Lisboa, Portugal ; APDP-ERC Portuguese Diabetes Association Education and Research Center, Rua do Salitre, No. 118-120, 1250-203 Lisbon, Portugal.
authors.forename: M Paula
authors.initials: MP
authors.lastname: Macedo
mesh_terms: D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D007333:Insulin Resistance; D007728:Kupffer Cells / Q000378:metabolism* / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D012307:Risk Factors