title: 4D PET iterative deconvolution with spatiotemporal regularization for quantitative dynamic PET imaging.
abstract: Quantitative measurements in dynamic PET imaging are usually limited by the poor counting statistics particularly in short dynamic frames and by the low spatial resolution of the detection system, resulting in partial volume effects (PVEs). In this work, we present a fast and easy to implement method for the restoration of dynamic PET images that have suffered from both PVE and noise degradation. It is based on a weighted least squares iterative deconvolution approach of the dynamic PET image with spatial and temporal regularization. Using simulated dynamic [(11)C] Raclopride PET data with controlled biological variations in the striata between scans, we showed that the restoration method provides images which exhibit less noise and better contrast between emitting structures than the original images. In addition, the method is able to recover the true time activity curve in the striata region with an error below 3% while it was underestimated by more than 20% without correction. As a result, the method improves the accuracy and reduces the variability of the kinetic parameter estimates calculated from the corrected images. More importantly it increases the accuracy (from less than 66% to more than 95%) of measured biological variations as well as their statistical detectivity.
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: anthonin@ansto.gov.au.
authors.forename: Anthonin
authors.initials: A
authors.lastname: Reilhac
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Charil
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Catriona
authors.initials: C
authors.lastname: Wimberley
authors.affiliation: Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Georgios
authors.initials: G
authors.lastname: Angelis
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Hasar
authors.initials: H
authors.lastname: Hamze
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Callaghan
authors.affiliation: UMR 1037 INSERM/UPS, CRCT, 31062 Toulouse, France; Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Garcia
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Frederic
authors.initials: F
authors.lastname: Boisson
authors.affiliation: Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Will
authors.initials: W
authors.lastname: Ryder
authors.affiliation: Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Meikle
authors.affiliation: Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia; Brain & Mind Research Institute, University of Sydney, Sydney, NSW, Australia.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Gregoire
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D009010:Monte Carlo Method; D059906:Neuroimaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D051381:Rats
keywords: Kinetic modeling; PET; Partial volume effects