title: Thrombophilia diagnosis: a retrospective analysis of a single-center experience.
abstract: It is estimated that 30-50% of patients suffering from deep vein thrombosis (DVT) could be diagnosed with congenital or acquired thrombophilia. Its diagnosis, however, rarely changes the clinical management, but is associated with significant costs and negative psychological and social aspects. The aim of this study was to perform a retrospective analysis of the causes and clinical consequences of diagnostics for thrombophilia. A retrospective review of the medical records of 5600 patients was performed, 62 of whom had, at the time, been diagnosed for thrombophilia because of a thromboembolic event. A review of the current literature on the validity of diagnostic tests for hypercoagulability in certain clinical conditions was also performed. The most common reason for thrombophilia testing was episodes of lower limb DVT (56%). The most frequently diagnosed abnormalities were the heterozygous form of the V Leiden gene (18%), protein S deficiency (11%), and the anti cardiolipin antibody IgG (11%). In 45% of the patients, laboratory results did not confirm the presence of any congenital thrombophilia. After receiving the results, 11% of the respondents completed oral anticoagulation therapy after 3 months, and 28% of patients qualified for indefinite use of oral anticoagulant therapy. In most of the cases examined, the diagnosis of thrombophilia did not significantly affect the treatment. A common aberration identified in patients with a history of thromboembolic incidents was the coexistence of risk factors for atherosclerosis.
authors.affiliation: aDepartment of Vascular and Internal Diseases bDepartment of General, Gastroenterological, Colorectal and Oncological Surgery, Jan Biziel University Hospital No. 2, Bydgoszcz cChair of Vascular and Internal Diseases, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Spychalska-Zwolińska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zwoliński
authors.forename: Artur
authors.initials: A
authors.lastname: Mieczkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Budzyński
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics; D055815:Young Adult