title: Antiangiogenic Metargidin Peptide (AMEP) Gene Therapy in Disseminated Melanoma.
abstract: Gene delivery by electroporation is an efficient method for transfecting genes into various tissues including tumors. Here we present the treatment protocol used in a phase 1 study on gene electrotransfer of plasmid DNA encoding an antiangiogenic peptide into cutaneous melanoma.
authors.affiliation: Department of Oncology, Center for Experimental Drug and Gene Electrotransfer, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark.
authors.forename: Iben
authors.initials: I
authors.lastname: Spanggaard
authors.forename: Julie
authors.initials: J
authors.lastname: Gehl
mesh_terms: D051722:ADAM Proteins / Q000235:genetics* / Q000627:therapeutic use*; D020533:Angiogenesis Inhibitors / Q000235:genetics* / Q000627:therapeutic use*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000628:therapy*; D008565:Membrane Proteins / Q000235:genetics* / Q000627:therapeutic use*; D012878:Skin Neoplasms; D000096142:Cutaneous Malignant Melanoma
chemical_list: D020533:Angiogenesis Inhibitors; D008565:Membrane Proteins; D051722:ADAM Proteins; C098660:ADAM15 protein, human