title: Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children.
abstract: This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10-24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10-24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10-24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample.
authors.affiliation: Emory University.
authors.forename: Michael
authors.initials: M
authors.lastname: Windle
authors.affiliation: University of Georgia.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Kogan
authors.affiliation: University of Georgia.
authors.forename: Sunbok
authors.initials: S
authors.lastname: Lee
authors.affiliation: University of Georgia.
authors.forename: Yi-Fu
authors.initials: YF
authors.lastname: Chen
authors.affiliation: University of Georgia.
authors.forename: Karlo Mankit
authors.initials: KM
authors.lastname: Lei
authors.affiliation: University of Georgia.
authors.forename: Gene H
authors.initials: GH
authors.lastname: Brody
authors.affiliation: University of Georgia.
authors.forename: Steven R H
authors.initials: SR
authors.lastname: Beach
authors.affiliation: University of Georgia.
authors.forename: Tianyi
authors.initials: T
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D001741:Black or African American / Q000235:genetics* / Q000523:psychology; D000483:Alleles; D002648:Child; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012111:Residence Characteristics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D019966:Substance-Related Disorders / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins