title: Gastroretentive Matrix Tablets of Boswellia Oleogum Resin: Preparation, Optimization, In Vitro Evaluation, and Cytoprotective Effect on Indomethacin-Induced Gastric Ulcer in Rabbits.
abstract: Currently available anti-ulcer drugs suffer from serious side effects which limited their uses and prompted the need to search for a safe and efficient new anti-ulcer agent. Boswellia gum resin (BR) emerged as a safe, efficient, natural, and economic potential cytoprotective agent. Thus, it is of medical importance to develop gastroretentive (GR) formulations of BR to enhance its bioavailability and anti-ulcer efficacy. Early attempts involved the use of organic solvents and non-applicability to large-scale production. In this study, different tablet formulations were prepared by simple direct compression combining floating and bioadhesion mechanisms employing hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (SCMC), pectin (PC), and/or carbopol (CP) as bioadhesive polymers and sodium bicarbonate (SB) as a gas former. The prepared tablets were subjected for assessment of swelling, floating, bioadhesion, and drug release in 0.1 N HCl. The optimized GR formulation was examined for its protective effect on the gastric ulcer induced by indomethacin in albino rabbits compared with lactose tablets. The obtained results disclosed that swelling, floating, bioadhesion, and drug release of the GR tablets of BR depend mainly on the nature of the matrix and the ratio of polymer combinations. Moreover, a combination of SCMC-CP in a ratio of 2:1 (SCP21) exhibited desirable floating, bioadhesion, swelling, and extended drug release. Also, a 6-h pretreatment with SCP21 tablets decreased the severity of inflammation and number of bleeding spots among ulcer-induced rabbits in comparison to those treated with lactose tablets.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. rehabyusif@yahoo.com.|Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, 41411, KSA. rehabyusif@yahoo.com.
authors.forename: Rehab Mohammad
authors.initials: RM
authors.lastname: Yusif
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
authors.forename: Irhan Ibrahim
authors.initials: II
authors.lastname: Abu Hashim
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
authors.forename: Elham Abdelmonem
authors.initials: EA
authors.lastname: Mohamed
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
authors.forename: Farid Abd-Elreheim
authors.initials: FA
authors.lastname: Badria
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D029743:Boswellia / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010368:Pectins / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D020011:Protective Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits; D012116:Resins, Plant / Q000737:chemistry*; D017693:Sodium Bicarbonate / Q000737:chemistry; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013607:Tablets / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000180:Acrylic Resins; D000897:Anti-Ulcer Agents; D005079:Excipients; D011108:Polymers; D020011:Protective Agents; D012116:Resins, Plant; D013607:Tablets; C006912:carboxypolymethylene; D065347:Hypromellose Derivatives; D010368:Pectins; D017693:Sodium Bicarbonate; D002266:Carboxymethylcellulose Sodium; D007213:Indomethacin
keywords: Boswellia gum resin; bioadhesion; cytoprotective; floating; gastroretentive