title: Large-Scale Synthesis of Crystalline 1,2,3,4,6,7-Hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose.
abstract: The higher-carbon sugar l-glycero-d-manno-heptose is a major constituent of the inner core region of the lipopolysaccharide (LPS) of many Gram-negative bacteria. All preparative routes used to date require multiple steps, and scalability has been rarely addressed. Here a highly practical synthesis of crystalline 1,2,3,4,6,7-hexa-O-acetyl-l-glycero-α-d-manno-heptopyranose by a simple four-step sequence starting from l-lyxose is disclosed. Only two recrystallisations are required and the process was demonstrated on a >100 mmol scale, yielding 41 g of the target compound.
authors.affiliation: Department of Chemistry, Durham University South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Christian
authors.initials: C
authors.lastname: Stanetty
authors.affiliation: Department of Chemistry, Durham University South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
keywords: Allylation; Carbohydrates; Indium; Rare sugars; Synthetic methods