title: Remote ischaemic preconditioning in intermittent claudication.
abstract: BACKGROUND
  Remote ischaemic preconditioning (RIPC) protects tissues against ischaemia-reperfusion (I/R) injury, a common occurrence in several clinical settings.
  
  
  OBJECTIVE
  To evaluate whether RIPC has a beneficial impact on walking disability in arterial intermittent claudication.
  
  
  METHODS
  A total of 20 patients with proven intermittent claudication underwent two treadmill walking tests with a 7-day interval in between; they were randomized according to the order in which they received either RIPC or a control procedure before the first treadmill test, with a crossover at the second test. Patients received three cycles of alternating 5-minute inflation and 5-minute deflation of blood-pressure cuffs on both arms, with inflation to a pressure of 200 mmHg in the RIPC procedure or 10mmHg in the control procedure. Walking distances and limb oxygenation data, assessed with transcutaneous oximetry and near infrared spectroscopy measurements, were obtained during both RIPC and control procedures in all patients.
  
  
  RESULTS
  Similar exercise intensities were achieved after the control and RIPC procedures. Walking distances did not significantly differ after the control and RIPC procedures (204 [141-259]m vs 215 [162-442]m, respectively; P=0.22). Similarly, no difference was observed in terms of transcutaneous oxygen pressure change and near infrared spectroscopy measurements during exercise between the two procedures.
  
  
  CONCLUSIONS
  RIPC did not improve walking distance or limb ischaemia variables in patients with peripheral artery disease and intermittent claudication.
authors.affiliation: L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France.
authors.forename: Hermeland
authors.initials: H
authors.lastname: Delagarde
authors.affiliation: L'UNAM université, Nantes, France; Service d'explorations fonctionnelles vasculaires et centre régional de médicine du sport, CHU d'Angers, Angers, France; Inserm U771, CNRS UMR 6214, université d'Angers, Angers, France.
authors.forename: Nafi
authors.initials: N
authors.lastname: Ouadraougo
authors.affiliation: L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Grall
authors.affiliation: L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Macchi
authors.affiliation: L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France.
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Roy
authors.affiliation: L'UNAM université, Nantes, France; Service d'explorations fonctionnelles vasculaires et centre régional de médicine du sport, CHU d'Angers, Angers, France; Inserm U771, CNRS UMR 6214, université d'Angers, Angers, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Abraham
authors.affiliation: L'UNAM université, Nantes, France; EA 3860 cardioprotection, remodelage et thrombose, université Angers, rue Haute-de-Reculée, 49045 Angers, France; Service de cardiologie, CHU d'Angers, Angers, France. Electronic address: faprunier@chu-angers.fr.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Prunier
mesh_terms: D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005602:France; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D058729:Peripheral Arterial Disease / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D020127:Recovery of Function; D012039:Regional Blood Flow; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors; D016896:Treatment Outcome; D034941:Upper Extremity / Q000098:blood supply*; D016138:Walking
keywords: Artériopathie oblitérante des membres inférieurs; Conditionnement ischémique à distance; Ischaemia-reperfusion; Ischémie-reperfusion; Peripheral artery disease; Remote conditioning