title: The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5.
abstract: Gastric cancer (GC) is one of the most common malignancies worldwide. Emerging evidence has shown that aberrant expression of microRNAs (miRNAs) plays important roles in cancer progression. However, little is known about the potential role of miR-217 in GC. In this study, we investigated the role of miR-217 on GC cell proliferation and invasion. The expression of miR-217 was down-regulated in GC cells and human GC tissues. Enforced expression of miR-217 inhibited GC cells proliferation and invasion. Moreover, Glypican-5 (GPC5), a new ocncogene, was identified as the potential target of miR-217. In addition, overexpression of miR-217 impaired GPC5-induced promotion of proliferation and invasion in GC cells. In conclusion, these findings revealed that miR-217 functioned as a tumor suppressor and inhibited the proliferation and invasion of GC cells by targeting GPC5, which might consequently serve as a therapeutic target for GC patients.
authors.affiliation: Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of neurology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of General Surgery, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Qin
authors.affiliation: Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, 650051, Yunnan, China.
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Gao
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D053673:Glypicans / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C106228:GPC5 protein, human; D053673:Glypicans; C553315:MIRN217 microRNA, human; D035683:MicroRNAs