title: Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats.
abstract: We studied the effects of fermented barley extract P (FBEP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male 10-week-old SHRSP were divided into three groups that were fed: an AIN-93M diet (control), a low dose of FBEP (4 g/kg; FBEP1), and a high dose of FBEP (20 g/kg; FBEP2) for three weeks. Hypertension was significantly improved by the use of FBEP supplementation. The FBEP diet improved plasma triglyceride, insulin sensitivity, enhanced plasma catalase, and superoxide dismutase activities, and decreased plasma 8-hydroxy-2'-deoxyguanosine levels. In addition, the FBEP diet upregulated hepatic antioxidative genes and modulated Nrf2 protein levels in the liver. Furthermore, a single oral dose of FBEP (2 g/kg body weight) was able to lower blood pressure in SHRSP. In conclusion, our data suggest that increased expression of hepatic antioxidative genes and modulation of Nrf2 may play a role in the regulation of metabolic diseases in SHRSP consuming a FBEP diet.
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.|b Department of Food Science and Technology , Universitas Bakrie , Jakarta , Indonesia.
authors.lastname: Ardiansyah
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shirakawa
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Puspo E
authors.initials: PE
authors.lastname: Giriwono
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Oguchi
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Ueda
authors.affiliation: c Research Laboratory , Sanwa Shurui Co., Ltd. , Usa , Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Hokazono
authors.affiliation: d Akita Research Institute for Food and Brewing , Akita , Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hiwatashi
authors.affiliation: d Akita Research Institute for Food and Brewing , Akita , Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: e Department of Biological Science and Technology , Tokyo University of Science , Tokyo , Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Sato
authors.affiliation: a Laboratory of Nutrition, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Komai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure; D019587:Dietary Supplements; D005285:Fermentation; D001467:Hordeum / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts
keywords: antioxidative; fermented barley extract; hypertension; stroke-prone spontaneously hypertensive rats