title: Psoriasis and New-onset Depression: A Danish Nationwide Cohort Study.
abstract: Psoriasis is associated with an increased risk of depression, but results are inconsistent. This study examined the risk of new-onset depression in patients with psoriasis in a nationwide Danish cohort including some 5 million people in the period 2001-2011. A total of 35,001 patients with mild psoriasis and 7,510 with severe psoriasis were identified. Incidence rates per 1,000 person-years and incidence rate ratios (IRRs) were calculated. Incidence rates for depression were 20.0 (95% confidence interval 19.9-20.0), 23.9 (23.1-24.7) and 31.6 (29.5-33.8) for the reference population, mild, and severe psoriasis, respectively. Adjusted for age, sex, and inclusion year, IRRs were 1.08 (1.04-1.12) in mild and 1.36 (1.27-1.46) in severe psoriasis. After adjustment for comorbidity, the IRR was significant in only patients < 50 years with severe psoriasis (IRR 1.23 (1.03-1.46)). In conclusion, the risk of new-onset depression in psoriasis is mediated primarily by comorbidities, except in younger individuals with severe psoriasis, in whom psoriasis itself may be a risk factor.
authors.affiliation: Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark. peter.jensen@regionh.dk, peter.jensen@gmail.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Jensen
authors.forename: Ole
authors.initials: O
authors.lastname: Ahlehoff
authors.forename: Alexander
authors.initials: A
authors.lastname: Egeberg
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gislason
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hansen
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D000328:Adult; D000367:Age Factors; D000928:Antidepressive Agents / Q000627:therapeutic use; D015897:Comorbidity; D003718:Denmark / Q000453:epidemiology; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D003879:Dermatologic Agents