title: Polymorphisms in Genes Coding for Cytokines, Mannose-Binding Lectin, Collagen Metabolism and Thrombophilia in Women with Cervical Insufficiency.
abstract: OBJECTIVE
  To study the association between cervical insufficiency and single nucleotide polymorphisms in seven genes coding for pro- and anti-inflammatory cytokine-related factors, mannose-binding lectin 2 (MBL2), collagen1α1 (COL1A1), factor II and factor V Leiden genes.
  
  
  METHODS
  In a case-control study, potential maternal biomarkers for cervical insufficiency were investigated in 30 women with a history of second-trimester miscarriage or preterm birth due to cervical insufficiency and in 70 control women.
  
  
  RESULTS
  Homozygous carriers of the interleukin 6 (IL6) -174 genotype GG had an odds ratio (OR) of 3.1 [95% confidence interval (95% CI) 1.3-7.4, p = 0.01] and MBL2 genotypes coding for low or intermediate levels of plasma MBL had an OR of 3.3 (95% CI 1.2-9.0, p = 0.01) for cervical insufficiency compared with controls. Serum MBL levels were lower in women with cervical insufficiency than in controls (median 408 and 1,985 ng/ml, respectively, p < 0.01).
  
  
  CONCLUSIONS
  Single nucleotide polymorphisms in the IL6 gene and the MBL2 gene and low MBL levels related to the latter polymorphism may increase the risk of preterm birth due to cervical insufficiency.
authors.affiliation: Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Iben
authors.initials: I
authors.lastname: Sundtoft
authors.forename: Niels
authors.initials: N
authors.lastname: Uldbjerg
authors.forename: Rudi
authors.initials: R
authors.lastname: Steffensen
authors.forename: Steffen
authors.initials: S
authors.lastname: Sommer
authors.forename: Ole Bjarne
authors.initials: OB
authors.lastname: Christiansen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D016207:Cytokines / Q000235:genetics*; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D047928:Premature Birth / Q000235:genetics*; D002581:Uterine Cervical Incompetence / Q000235:genetics*; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; C095381:factor V Leiden; D005165:Factor V