title: Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects.
abstract: Tumor-homing and pH-responsive polypeptide-drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly better anti-tumor efficacy and less systemic toxicity than not only free drugs, but also polypeptide-drug nanoparticles without the tumor-homing function.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China. gaoweiping@tsinghua.edu.cn.
authors.forename: Jin
authors.initials: J
authors.lastname: Hu
authors.forename: Lining
authors.initials: L
authors.lastname: Xie
authors.forename: Wenguo
authors.initials: W
authors.lastname: Zhao
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Sun
authors.forename: Xinyu
authors.initials: X
authors.lastname: Liu
authors.forename: Weiping
authors.initials: W
authors.lastname: Gao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000009:adverse effects / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D016503:Drug Delivery Systems; D004549:Elastin / Q000009:adverse effects / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010455:Peptides / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D010455:Peptides; D004317:Doxorubicin; D004549:Elastin