title: Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study.
abstract: The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China; Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Guo
authors.affiliation: Breast Disease Center, Peking University First Hospital, Beijing, China.
authors.forename: Xue-ning
authors.initials: XN
authors.lastname: Duan
authors.affiliation: Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Shu-de
authors.initials: SD
authors.lastname: Cui
authors.affiliation: Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.
authors.forename: Fu-guo
authors.initials: FG
authors.lastname: Tian
authors.affiliation: National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
authors.forename: Xu-chen
authors.initials: XC
authors.lastname: Cao
authors.affiliation: Breast Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Cui-zhi
authors.initials: CZ
authors.lastname: Geng
authors.affiliation: Department of Breast Surgery, the First Hospital of Jilin University, Changchun, Jilin, China.
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Fan
authors.affiliation: Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Breast Disease Center, Peking University People's Hospital, Beijing, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Beijing Chaoyang Hospital, Beijing, China.
authors.forename: Hong-chuan
authors.initials: HC
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Zhang
authors.affiliation: Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.affiliation: Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China.
authors.forename: Jin-hai
authors.initials: JH
authors.lastname: Tang
authors.affiliation: Department of General Surgery, Linyi People's Hospital, Linyi, Shandong, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.affiliation: Department of Thyroid and Breast Surgery, the First Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China.
authors.forename: Zhen-lin
authors.initials: ZL
authors.lastname: Yang
authors.affiliation: Breast Center, Qingdao University Affiliated Hospital, Qingdao, Shandong, China.
authors.forename: Hai-bo
authors.initials: HB
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, the Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, Shandong, China.
authors.forename: Qi-tang
authors.initials: QT
authors.lastname: Wang
authors.affiliation: Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong, China.
authors.forename: Guo-lou
authors.initials: GL
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
authors.forename: Shi-guang
authors.initials: SG
authors.lastname: Zhu
authors.affiliation: Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Wen-shu
authors.initials: WS
authors.lastname: Zuo
authors.affiliation: Epidemiology Institute, School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: Li-yuan
authors.initials: LY
authors.lastname: Liu
authors.affiliation: Division of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China.
authors.forename: Dan-dan
authors.initials: DD
authors.lastname: Ma
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China.
authors.forename: Shu-chen
authors.initials: SC
authors.lastname: Liu
authors.affiliation: Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Yu-juan
authors.initials: YJ
authors.lastname: Xiang
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China.
authors.forename: Chun-miao
authors.initials: CM
authors.lastname: Ye
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, China.
authors.forename: Wen-zhong
authors.initials: WZ
authors.lastname: Zhou
authors.affiliation: Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Li-xiang
authors.initials: LX
authors.lastname: Yu
authors.affiliation: Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Zhong-bing
authors.initials: ZB
authors.lastname: Ma
authors.affiliation: Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Yu
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D011379:Prognosis; D012306:Risk
chemical_list: D052242:Adiponectin