title: Invasive Microascus trigonosporus Species Complex Pulmonary Infection in a Lung Transplant Recipient.
abstract: Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this prophylaxis is not universally effective and may contribute to the selection of emerging, resistant pathogens. Here we present a rare case of invasive infection caused by Microascus trigonosporus species complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. Nebulized liposomal amphotericin B was used in addition to systemic therapy in order to optimize antifungal drug exposure; this regimen appeared to reduce the patient's fungal burden. Despite this apparent improvement, the patient's pulmonary status progressively declined in the setting of multiple comorbidities, ultimately leading to respiratory failure and death.
authors.affiliation: Department of Pharmacy, University of Colorado Hospital, Aurora, CO 80010, USA.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Schoeppler
authors.affiliation: Department of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USA.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Zamora
authors.affiliation: Hospitalist Medicine, Denver Health and Hospital, Denver, CO 80204, USA.
authors.forename: Noelle M
authors.initials: NM
authors.lastname: Northcutt
authors.affiliation: Department of Pharmacy, University of Colorado Hospital, Aurora, CO 80010, USA.
authors.forename: Gerard R
authors.initials: GR
authors.lastname: Barber
authors.affiliation: Department of Mycology, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USA.
authors.forename: Gayle
authors.initials: G
authors.lastname: O'Malley-Schroeder
authors.affiliation: Department of Pulmonary and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80010, USA.
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Lyu