title: Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat.
abstract: To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti"). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (SC). Pharmacological inactivation of rat medial PFC supported its expected role in Anti. Remarkably, bilateral SC inactivation substantially impaired Anti while leaving Pro essentially intact. Moreover, SC inactivation eliminated the performance cost of switching from Anti to Pro tasks. Our results establish a rodent model of single-trial sensorimotor remapping and suggest a critical role for SC in the cognitively demanding Anti task.
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
authors.forename: Chunyu A
authors.initials: CA
authors.lastname: Duan
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai 200122, China.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Erlich
authors.affiliation: Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute. Electronic address: brody@princeton.edu.
authors.forename: Carlos D
authors.initials: CD
authors.lastname: Brody
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D056344:Executive Function / Q000187:drug effects / Q000502:physiology*; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D018755:GABA Agonists / Q000494:pharmacology; D007266:Inhibition, Psychological; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009949:Orientation / Q000187:drug effects / Q000502:physiology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000187:drug effects; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*
chemical_list: D018755:GABA Agonists; D009118:Muscimol