title: Chemotherapeutic treatment of colorectal cancer in pregnancy: case report.
abstract: BACKGROUND
  Colon cancer in pregnancy is uncommon. Only a small number of case reports have been published in the literature on the use of chemotherapeutic drugs during pregnancy. Reports of such cases assist clinicians in further investigating the use of chemotherapy in pregnancy.
  
  
  METHODS
  FOLFOX-6 was administered to a pregnant, 33-year-old Saudi woman with metastatic colon cancer from 22 to 30 weeks of gestation. Her cancer was diagnosed during her pregnancy. She tolerated the chemotherapy well and delivered a full-term baby girl with no obvious harm, and normal development was documented at her 2-year follow-up examination.
  
  
  CONCLUSIONS
  Colon cancer during pregnancy is not easily detected and is difficult to manage. A detailed history and high clinical suspicion are needed in patients who present with symptoms and signs suggestive of malignancy. A multidisciplinary approach with patient involvement is needed to decrease morbidity and mortality caused by both treatment and the cancer in the mother and to limit side effects for the fetus. Further data and long-term follow-up are needed to better understand the potential long-term side effects of chemotherapeutic drugs on offspring.
authors.affiliation: Department of Surgery, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. zmakoshi@gmail.com.|Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Civic Campus, Ottawa, ON, Canada. zmakoshi@gmail.com.
authors.forename: Ziyad
authors.initials: Z
authors.lastname: Makoshi
authors.affiliation: Southampton School of Medicine, University of Southampton, Southampton, UK. c.perrott@live.co.uk.
authors.forename: Claire
authors.initials: C
authors.lastname: Perrott
authors.affiliation: Department of Obstetrics and Gynecology, Women's Specialist Hospital, King Fahad Medical City, Riyadh, Saudi Arabia. khadija.alkhatani@gmail.com.
authors.forename: Khadija
authors.initials: K
authors.lastname: Al-Khatani
authors.affiliation: Department of Pathology, King Khalid University Hospital, Riyadh, Saudi Arabia. fadia.almohaisen@gmail.com.
authors.forename: Fadia
authors.initials: F
authors.lastname: Al-Mohaisen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000556:secondary; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000556:secondary; D010052:Ovariectomy; D000077150:Oxaliplatin; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil