title: Risk of venous thromboembolism in patients with Sjögren's syndrome: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on Sjögren's syndrome (SS) remain unclear. This study aimed to investigate this association.
  
  
  METHODS
  We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardised incidence ratio comparing risk of VTE in patients with SS versus non-SS subjects. Pooled risk ratio and 95% confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.
  
  
  RESULTS
  Out of 306 potentially relevant articles, four eligible studies were identified and included in the data analysis. The pooled risk ratio of VTE in patients with SS was 2.05 (95% CI, 1.86-2.27). The statistical heterogeneity of this study was insignificant with an I2 of 0%.
  
  
  CONCLUSIONS
  Our study demonstrated a statistically significant increased VTE risk among patients with SS.
authors.affiliation: Division of Rheumatology, Mayo Clinic, Rochester, USA.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Division of Pulmonology and Critical Care Medicine, Mayo Clinic, Rochester, USA.
authors.forename: Narat
authors.initials: N
authors.lastname: Srivali
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA.
authors.forename: Wonngarm
authors.initials: W
authors.lastname: Kittanamongkolchai
mesh_terms: D016009:Chi-Square Distribution; D006801:Humans; D016017:Odds Ratio; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D054556:Venous Thromboembolism / Q000097:blood / Q000175:diagnosis / Q000209:etiology*