title: Comparison of lyophilized glutaraldehyde-preserved bovine pericardium with different vascular prostheses for use as vocal cords implants: experimental study.
abstract: This study compared the use of lyophilized glutaraldehyde-preserved bovine pericardium (LGPBP), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), and Teflon felt (TF) as implants for vocal cords (VC) medialization and aimed to assess the endoscopic, macroscopic, and microscopic VC changes after medialization in a canine model. In 18 mongrel dogs, the right VC were medialized with LGPBP and the left were implanted as follows: Group I (n = 6): LGPBP and PTFE; Group II (n = 6): LGPBP and PET; Group III (n = 6): LGPBP and TF. Surgical handling of the implants was compared. Three months after surgery, macroscopic and microscopic changes of VC and implants were evaluated. LGPBP offered the best surgical handling (p = 0.005, Kruskal-Wallis). TF implants showed extrusion (p = 0.005, Kruskal-Wallis) and severe inflammation. All VC formed fibrous capsules around the implants; the ones developed by LGPBP implants were thinner (p = 0.001, ANOVA, Tukey). VC implanted with synthetic materials showed eosinophilic infiltration (p = 0.01, Kruskal-Wallis). We concluded that the LGPBP could be used as an implant for VC medialization because it is biocompatible, easy to handle and remove during surgical procedures, and nonabsorbable or extrudable and produces an inflammatory reaction similar to PTFE and PET.
authors.affiliation: Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: J Raúl
authors.initials: JR
authors.lastname: Olmos-Zuñiga
authors.affiliation: Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Jasso-Victoria
authors.affiliation: Department of Morphology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gaxiola-Gaxiola
authors.affiliation: Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Avelina
authors.initials: A
authors.lastname: Sotres-Vega
authors.affiliation: Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hernández-Jiménez
authors.affiliation: Department of Surgical Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Matilde
authors.initials: M
authors.lastname: Baltazares-Lipp
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Arredondo del Bosque
authors.affiliation: Medical Direction, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Tlalpan, 14080 Mexico City, DF, Mexico.
authors.forename: Patricio
authors.initials: P
authors.lastname: Santillan-Doherty
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002417:Cattle; D004285:Dogs; D005612:Freeze Drying; D005976:Glutaral; D020007:Implants, Experimental; D010496:Pericardium; D014827:Vocal Cords / Q000601:surgery*
chemical_list: D005976:Glutaral