title: Removing silicone artifacts in diffusion-weighted breast MRI by means of shift-resolved spatiotemporally encoding.
abstract: OBJECTIVE
  Evaluate the usefulness of diffusion-weighted spatiotemporally encoded (SPEN) methods to obtain apparent diffusion coefficient (ADC) maps of fibroglandular human breast tissue, in the presence of silicone implants.
  
  
  METHODS
  Seven healthy volunteers with breast augmentation were scanned at 3 Tesla (T) using customized SPEN sequences yielding separate silicone and water (1) H images in one scan, together with their corresponding diffusion-weightings.
  
  
  RESULTS
  SPEN's ability to deliver multiple spectrally resolved images in a single scan, coupled to the method's substantial robustness to magnetic field heterogeneities, served to acquire ADC maps that could be freed from contributions that did not belong to fibroglandular tissue.
  
  
  CONCLUSIONS
  SPEN-based sequences incorporating spectral discrimination and diffusion-weighting enable the acquisition of reliable ADC maps despite the presence of dominant signals from silicone implants, thereby opening new screening possibilities for the identification of malignancies in breast augmented patients.
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Eddy
authors.initials: E
authors.lastname: Solomon
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Noam
authors.initials: N
authors.lastname: Nissan
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Rita
authors.initials: R
authors.lastname: Schmidt
authors.affiliation: Unit of Biological Services, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Edna
authors.initials: E
authors.lastname: Furman-Haran
authors.affiliation: Breast Surgery Unit, Meuhedet Clinic, Ashdod, Israel.
authors.forename: Uriel
authors.initials: U
authors.lastname: Ben-Aharon
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel.
authors.forename: Lucio
authors.initials: L
authors.lastname: Frydman
mesh_terms: D000328:Adult; D016477:Artifacts; D001940:Breast / Q000000981:diagnostic imaging* / Q000601:surgery; D018427:Breast Implants; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D060526:Magnetic Fields; D008875:Middle Aged; D015233:Models, Statistical; D019047:Phantoms, Imaging; D019736:Prostheses and Implants; D012828:Silicones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D012828:Silicones; D014867:Water
keywords: breast MRI; diffusion-weighted imaging - DWI; silicone implants; spatiotemporal encoding - SPEN