title: Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study.
abstract: BACKGROUND
  Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile.
  
  
  METHODS
  In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied.
  
  
  RESULTS
  Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain.
  
  
  CONCLUSIONS
  Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Emilia
authors.initials: E
authors.lastname: Salvadori
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Poggesi
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Valenti
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pracucci
authors.affiliation: Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pescini
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Pasi
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Nannucci
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Sandro
authors.initials: S
authors.lastname: Marini
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Del Bene
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Ciolli
authors.affiliation: "Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ginestroni
authors.affiliation: Department of Electrical, Electronic, and Information Engineering "Guglielmo Marconi", University of Bologna, Cesena, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Diciotti
authors.affiliation: Department of Neurosciences, University of Pisa, Pisa, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Orlandi
authors.affiliation: Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Di Donato
authors.affiliation: Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: De Stefano
authors.affiliation: Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
authors.forename: Mirco
authors.initials: M
authors.lastname: Cosottini
authors.affiliation: Department of Neurosciences, University of Pisa, Pisa, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiti
authors.affiliation: Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Federico
authors.affiliation: Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Dotti
authors.affiliation: Department of Neurosciences, University of Pisa, Pisa, Italy.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Inzitari
authors.affiliation: NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy; Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. Electronic address: leonardo.pantoni@unifi.it.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pantoni
mesh_terms: D000368:Aged; D001284:Atrophy; D002561:Cerebrovascular Disorders / Q000175:diagnosis*; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007558:Italy; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D062706:Prodromal Symptoms; D011446:Prospective Studies; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D066127:White Matter / Q000000981:diagnostic imaging
keywords: Cerebrovascular disease; Cognitive aging; Mild cognitive impairment; Neuropsychology; Vascular dementia