title: Hypotension After Cardiac Operations Based on Autoregulation Monitoring Leads to Brain Cellular Injury.
abstract: BACKGROUND
  Individualizing blood pressure targets could improve organ perfusion compared with current practices. In this study we assess whether hypotension defined by cerebral autoregulation monitoring vs standard definitions is associated with elevation in the brain-specific injury biomarker glial fibrillary acidic protein plasma levels (GFAP).
  
  
  METHODS
  Plasma GFAP levels were measured in 121 patients undergoing cardiac operations after anesthesia induction, at the conclusion of the operation, and on postoperative day 1. Cerebral autoregulation was monitored during the operation with the cerebral oximetry index, which correlates low-frequency changes in mean arterial pressure (MAP) and regional cerebral oxygen saturation. Blood pressure was recorded every 15 minutes in the intensive care unit. Hypotension was defined based on autoregulation data as an MAP below the optimal MAP (MAP at the lowest cerebral oximetry index) and based on standard definitions (systolic blood pressure decrement >20%, >30% from baseline, or <100 mm Hg, or both).
  
  
  RESULTS
  MAP (mean ± standard deviation) in the intensive care unit was 74 ± 7.3 mm Hg; optimal MAP was 78 ± 12.8 mm Hg (p = 0.008). The incidence of hypotension varied from 22% to 37% based on standard definitions but occurred in 54% of patients based on the cerebral oximetry index (p < 0.001). There was no relationship between standard definitions of hypotension and plasma GFAP levels, but MAP of less than optimal was positively related with postoperative day 1 GFAP levels (coefficient, 1.77; 95% confidence interval, 1.27 to 2.48; p = 0.001) after adjusting for GFAP levels at the conclusion of the operation and low cardiac output syndrome.
  
  
  CONCLUSIONS
  Individualizing blood pressure management using cerebral autoregulation monitoring may better ensure brain perfusion than current practice.
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Daijiro
authors.initials: D
authors.lastname: Hori
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ono
authors.affiliation: Department of Anesthesiology & Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Rappold
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: John V
authors.initials: JV
authors.lastname: Conte
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Ashish S
authors.initials: AS
authors.lastname: Shah
authors.affiliation: Division of Cardiac Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Duke E
authors.initials: DE
authors.lastname: Cameron
authors.affiliation: Department of Cardiovascular Surgery, Saitama Medical Center Jichi Medical University, Saitama, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Adachi
authors.affiliation: Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Allen D
authors.initials: AD
authors.lastname: Everett
authors.affiliation: Department of Anesthesiology & Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: chogue2@jhmi.edu.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Hogue
mesh_terms: D000368:Aged; D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000209:etiology* / Q000473:pathology*; D002315:Cardiopulmonary Bypass; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D007022:Hypotension / Q000150:complications* / Q000503:physiopathology; D064795:Intraoperative Neurophysiological Monitoring; D008297:Male; D010092:Oximetry; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology*; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein