title: Tuning the surface microstructure of titanate coatings on titanium implants for enhancing bioactivity of implants.
abstract: Biological performance of artificial implant materials is closely related to their surface characteristics, such as microtopography, and composition. Therefore, convenient fabrication of artificial implant materials with a cell-friendly surface structure and suitable composition was of great significance for current tissue engineering. In this work, titanate materials with a nanotubular structure were successfully fabricated through a simple chemical treatment. Immersion test in a simulated body fluid and in vitro cell culture were used to evaluate the biological performance of the treated samples. The results demonstrate that the titanate layer with a nanotubular structure on Ti substrates can promote the apatite-inducing ability remarkably and greatly enhance cellular responses. This highlights the potential of such titanate biomaterials with the special nanoscale structure and effective surface composition for biomedical applications such as bone implants.
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China ; State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China.
authors.forename: Yue-Kun
authors.initials: YK
authors.lastname: Lai
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China.
authors.forename: Ru-Yue
authors.initials: RY
authors.lastname: Zheng
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Bian
authors.affiliation: National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People's Republic of China.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, People's Republic of China.
authors.forename: Chang-Jian
authors.initials: CJ
authors.lastname: Lin
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001031:Apatites / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D051379:Mice; D019736:Prostheses and Implants; D013499:Surface Properties; D023822:Tissue Engineering; D014025:Titanium / Q000737:chemistry*
chemical_list: D001031:Apatites; D020099:Coated Materials, Biocompatible; D014025:Titanium
keywords: biological perfor mance; bone-like apatite; cell culture; nanotubes structure