title: Phenytoin as an effective treatment for polymorphic ventricular tachycardia due to QT prolongation in a patient with multiple drug intolerances.
abstract: We present a case of a 69-year-old woman presenting with polymorphic ventricular tachycardia caused by QT prolongation. Owing to known intolerances to a majority of antiarrhythmic medications, one remaining option was to initiate phenytoin. Phenytoin's narrow therapeutic window, multiple drug interactions and side effect profile make it an infrequently used antiarrhythmic. It is, however, a potent antiarrhythmic agent, which may be useful in treatment of ventricular tachycardia, especially in patients with multiple drug intolerances.
authors.affiliation: Albany Medical College, Albany, New York, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Yager
authors.affiliation: Albany Medical College, Albany, New York, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Wang
authors.affiliation: Albany Medical College, Albany, New York, USA.
authors.forename: Najiba
authors.initials: N
authors.lastname: Keshwani
authors.affiliation: Albany Medical College, Albany, New York, USA.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Torosoff
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications*; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use*; D017180:Tachycardia, Ventricular / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D010672:Phenytoin