title: Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China.
abstract: BACKGROUND
  Drug response variability observed amongst patients is caused by the interaction of both genetic and non-genetic factors, and frequencies of functional genetic variants are known to vary amongst populations. Pharmacogenomic research has the potential to help with individualized treatments. We have not found any pharmacogenomics information regarding Uygur ethnic group in northwest China. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Uygur population and compared our data with other eleven populations from the HapMap data set.
  
  
  RESULTS
  Through statistical analysis, we found that CYP3A5 rs776746, VKORC1 rs9934438, and VKORC1 rs7294 were most different in Uygur compared with most of the eleven populations from the HapMap data set. Compared with East Asia populations, allele A of rs776746 is less frequent and allele A of rs7294 is more frequent in the Uygur population. The analysis of F-statistics (Fst) and population structure shows that the genetic background of Uygur is relatively close to that of MEX.
  
  
  CONCLUSIONS
  Our results show significant differences amongst Chinese populations that will help clinicians triage patients for better individualized treatments.
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China. Li_wangprof@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Drug Analysis, Faculty of Pharmacy, Xinjiang Medical University, Urumqi, 830054, China. Ainiwaer_Aikemu@163.com.
authors.forename: Ainiwaer
authors.initials: A
authors.lastname: Aikemu
authors.affiliation: Department of radiotherapy two, The people's hospital of Xinjiang Uygur Autonomous Region, #91 Tianchi Road, Urumqi, 830001, , Xinjiang, China. Ayiguli_Yibulayin@163.com.
authors.forename: Ayiguli
authors.initials: A
authors.lastname: Yibulayin
authors.affiliation: School of Life Sciences, Northwest University, Mailbox 386, #229 North Taibai Road, Xi'an, 710069, , Shaanxi, China. Shuli_du@163.com.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. Shuli_du@163.com.
authors.forename: Shuli
authors.initials: S
authors.lastname: Du
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. gengttlife@163.com.
authors.forename: Tingting
authors.initials: T
authors.lastname: Geng
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. wangbo_life@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. zhangyuan_life@163.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, 712082, China. jintianboNW@163.com.|School of Life Sciences, Northwest University, Mailbox 386, #229 North Taibai Road, Xi'an, 710069, , Shaanxi, China. jintianboNW@163.com.|National Engineering Research Center for Miniaturized Detection Systems, Xi'an, 710069, China. jintianboNW@163.com.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of radiotherapy two, The people's hospital of Xinjiang Uygur Autonomous Region, #91 Tianchi Road, Urumqi, 830001, , Xinjiang, China. 13579879118@163.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
mesh_terms: D000483:Alleles; D001499:Bayes Theorem; D002681:China; D016000:Cluster Analysis; D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide