title: Neonatal drug therapy: The first frontier of therapeutics for children.
abstract: Knowledge about the safe and effective use of medicines in neonates has increased substantially but has resulted in few label changes. Drugs developed for use in adults are reshaped and tailored to specific neonatal indications. However, the use of drugs in neonates should not only mirror adult pharmacotherapy, but should be driven by their own specific needs. Therefore, building collaborative networks may assist to develop a newborn-driven research agenda addressing their clinical needs and diseases.
authors.affiliation: Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.|Department of Development and Regeneration, KU, Leuven, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Allegaert
authors.affiliation: Division of Pediatric Clinical Pharmacology, Children's National Health System, Washington, DC, USA.|Departments of Pediatrics, Integrative Systems Biology, Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.|Intensive Care and Department of Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.|Department of Paediatric Pharmacology, University Children's Hospital Basel, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: van den Anker
mesh_terms: D000367:Age Factors; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002657:Child Development; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D004364:Pharmaceutical Preparations