title: Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap.
abstract: TCF21 is a basic helix-loop-helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461).
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: S T
authors.initials: ST
authors.lastname: Nurnberg
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: K
authors.initials: K
authors.lastname: Cheng
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
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authors.initials: A
authors.lastname: Raiesdana
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
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authors.initials: R
authors.lastname: Kundu
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
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authors.initials: CL
authors.lastname: Miller
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: J B
authors.initials: JB
authors.lastname: Kim
authors.affiliation: Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii 96813.
authors.forename: K
authors.initials: K
authors.lastname: Arora
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: I
authors.initials: I
authors.lastname: Carcamo-Oribe
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: Y
authors.initials: Y
authors.lastname: Xiong
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: N
authors.initials: N
authors.lastname: Tellakula
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: V
authors.initials: V
authors.lastname: Nanda
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: N
authors.initials: N
authors.lastname: Murthy
authors.affiliation: Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii 96813.
authors.forename: W A
authors.initials: WA
authors.lastname: Boisvert
authors.affiliation: Departments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Hedin
authors.affiliation: Departments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Perisic
authors.affiliation: Departments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Aldi
authors.affiliation: Departments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Maegdefessel
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: M
authors.initials: M
authors.lastname: Pjanic
authors.affiliation: Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908.
authors.forename: G K
authors.initials: GK
authors.lastname: Owens
authors.affiliation: Center for Cardiovascular Research, University of Hawaii, Honolulu, Hawaii 96813.
authors.forename: M D
authors.initials: MD
authors.lastname: Tallquist
authors.affiliation: Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford CA 94305.
authors.forename: T
authors.initials: T
authors.lastname: Quertermous