title: Comparing three toothpastes in controlling plaque and gingivitis: A 6-month clinical study.
abstract: OBJECTIVE
  To investigate the clinical efficacy of three toothpastes in controlling established gingivitis and plaque over 6 months.
  
  
  METHODS
  135 subjects were enrolled in a single-center, double-blind, parallel group, randomized clinical study. Subjects were randomly assigned to one of three treatments: triclosan/copolymer/fluoride dentifrice containing 0.3% triclosan, 2.0% copolymer and 1,450 ppm F as sodium fluoride in a silica base; herbal/bicarbonate dentifrice containing herbal extract and 1,400 ppm F as sodium fluoride in a sodium bicarbonate base; or fluoride dentifrice containing 450 ppm F as sodium fluoride, and 1,000 ppm F as sodium monofluorophosphate. Subjects were instructed to brush their teeth twice daily for 1 minute for 6 months.
  
  
  RESULTS
  After 6 months, subjects assigned to the triclosan/copolymer/fluoride group exhibited statistically significant reductions in gingival index scores and plaque index scores as compared to subjects assigned to the herbal/bicarbonate group by 35.4% and 48.9%, respectively. There were no statistically significant differences in gingival index and plaque index between subjects in the herbal/ bicarbonate group and those in the fluoride group. The triclosan/copolymer/fluoride dentifrice was statistically significantly more effective in reducing gingivitis and dental plaque than the herbal/bicarbonate dentifrice, and this difference in efficacy was clinically meaningful.
authors.forename: Terdphong
authors.initials: T
authors.lastname: Triratana
authors.forename: Petcharat
authors.initials: P
authors.lastname: Kraivaphan
authors.forename: Cholticha
authors.initials: C
authors.lastname: Amornchat
authors.forename: Luis R
authors.initials: LR
authors.lastname: Mateo
authors.forename: Boyce M
authors.initials: BM
authors.lastname: Morrison
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
authors.forename: Yun-Po
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D003802:Dentifrices / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010710:Phosphates / Q000627:therapeutic use; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome; D014260:Triclosan / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D010710:Phosphates; D010936:Plant Extracts; D014100:Toothpastes; C012980:fluorophosphate; D014260:Triclosan; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride; D005459:Fluorides