title: Serum Krebs von den Lungen-6 level as a diagnostic biomarker for interstitial lung disease in Chinese patients.
abstract: OBJECTIVE
  The purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs).
  
  
  METHODS
  A total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined.
  
  
  RESULTS
  Serum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.09 ± 2230.08 U/mL vs 258.67 ± 268.73 U/mL or 178.73 ± 71.17 U/mL, all P < 0.05). At the cut-off value of 500 U/mL, the sensitivity and specificity of serum KL-6 as a diagnostic marker for ILDs was 77.75% and 94.51%, respectively. The Kappa value was 0.743 (P < 0.001). The area below the receiver operating characteristic curve was 0.922 with a 95% Confidence interval of 0.904-0.941 (P < 0.001). The posttreatment serum KL-6 levels significantly reduced in patients with improved ILDs, whereas markedly increased in patients with exacerbated ILDs (All P < 0.05).
  
  
  CONCLUSIONS
  Serum KL-6 levels might be a promising diagnostic biomarker for ILDs in Chinese patients. The prognostic value of serum KL-6 levels for ILDs remains to be verified by large-scaled studies.
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Liu-Sheng
authors.initials: LS
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Jin
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Du
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Yu-Kui
authors.initials: YK
authors.lastname: Du
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Xian
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Weng
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Yi-Liang
authors.initials: YL
authors.lastname: Su
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Ding
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Hou-Rong
authors.initials: HR
authors.lastname: Cai
authors.affiliation: Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Dai
authors.affiliation: Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors.forename: Jing-Hong
authors.initials: JH
authors.lastname: Dai
authors.affiliation: Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood*; D002681:China / Q000453:epidemiology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D011379:Prognosis; D012129:Respiratory Function Tests / Q000379:methods; D014797:Vital Capacity / Q000502:physiology
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1
keywords: KL-6; biomarker; diagnosis; interstitial lung disease; prognosis