title: Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance.
abstract: BACKGROUND
  To analyze the association between the plasma C1q/TNF-related protein-3 (CTRP-3) concentrations, obesity, and type II diabetes in the Chinese population.
  
  
  METHODS
  The plasma CTRP-3 concentrations were analyzed in 174 Chinese subjects with obesity (n = 43), type II diabetes (n = 41), obesity combined with type II diabetes (n = 45), and healthy subjects (n = 45), as were various clinical parameters of obesity-related metabolic disorders and adipokines.
  
  
  RESULTS
  The plasma CTRP-3 concentrations were significantly lower in patients with obesity and type II diabetes than in healthy subjects (P < .01). Obese type II diabetic patients had the lowest CTRP-3 concentrations. Correlation analysis revealed that the plasma CTRP-3 concentrations were significantly negatively correlated with body mass index, waist circumferences, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, triglyceride, fasting insulin, homeostasis model assessment for insulin resistance, and interleukin 6 levels and were positively correlated with high-density lipoprotein cholesterol level (all P < .01). Multiple linear regression analysis showed that hemoglobin A1c (β = -0.232, P = .023), triglyceride (β = -0.147, P = .040), and homeostasis model assessment for insulin resistance (β = -0.172, P = .031) were independently correlated with circulating CTRP-3. Multivariate logistic regression analysis revealed that plasma CTRP-3 concentrations were significantly correlated with obesity, even after adjusting for glucose metabolic factors.
  
  
  CONCLUSIONS
  Chinese patients with obesity and type II diabetes have significantly lower plasma CTRP-3 concentrations than healthy subjects do, and plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Qu
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Huili
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: deng_huacong@126.com.
authors.forename: Huacong
authors.initials: H
authors.lastname: Deng
mesh_terms: D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D048069:Tumor Necrosis Factors / Q000097:blood*
chemical_list: D001786:Blood Glucose; C506069:C1QTNF3 protein, human; D048069:Tumor Necrosis Factors
keywords: CTRP-3; Inflammation; Insulin resistance; Obesity; Type II diabetes mellitus