title: The Role of Storage Lipids in the Relation between Fecundity, Locomotor Activity, and Lifespan of Drosophila melanogaster Longevity-Selected and Control Lines.
abstract: The contribution of insect fat body to multiple processes, such as development, metamorphosis, activity, and reproduction results in trade-offs between life history traits. In the present study, age-induced modulation of storage lipid composition in Drosophila melanogaster longevity-selected (L) and non-selected control (C) lines was studied and the correlation between total body fat mass and lifespan assessed. The trade-offs between fecundity, locomotor activity, and lifespan were re-evaluated from a lipid-related metabolic perspective. Fewer storage lipids in the L lines compared to the C lines supports the impact of body fat mass on extended lifespan. The higher rate of fecundity and locomotor activity in the L lines may increase the lipid metabolism and enhance the lipolysis of storage lipids, reducing fat reserves. The correlation between neutral lipid fatty acids and fecundity, as well as locomotor activity, varied across age groups and between the L and C lines. The fatty acids that correlated with egg production were different from the fatty acids that correlated with locomotor activity. The present study suggests that fecundity and locomotor activity may positively affect the lifespan of D. melanogaster through the inhibition of fat accumulation.
authors.affiliation: Department of Bioscience, Aarhus University, Ny Munkegade 114, DK-8000 Aarhus C, Denmark.
authors.forename: Neda
authors.initials: N
authors.lastname: Nasiri Moghadam
authors.affiliation: Department of Bioscience, Aarhus University, Vejlsøvej 25, PO Box 314, DK-8600 Silkeborg, Denmark.
authors.forename: Martin
authors.initials: M
authors.lastname: Holmstrup
authors.affiliation: Department of Bioscience, Aarhus University, Ny Munkegade 114, DK-8000 Aarhus C, Denmark.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Manenti
authors.affiliation: Department of Bioscience, Aarhus University, Ny Munkegade 114, DK-8000 Aarhus C, Denmark.
authors.forename: Marie
authors.initials: M
authors.lastname: Brandt Mouridsen
authors.affiliation: Aalborg Zoo, Mølleparkvej 63, 9000 Aalborg, Denmark; Department 18 / Section of Environmental Engineering, Aalborg University, Sohngårdsholmvej 57, 9000 Aalborg, Denmark.
authors.forename: Cino
authors.initials: C
authors.lastname: Pertoldi
authors.affiliation: Department of Bioscience, Aarhus University, Ny Munkegade 114, DK-8000 Aarhus C, Denmark.
authors.forename: Volker
authors.initials: V
authors.lastname: Loeschcke
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000378:metabolism / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000502:physiology*; D016014:Linear Models; D050356:Lipid Metabolism / Q000502:physiology*; D008124:Locomotion / Q000502:physiology*; D008136:Longevity / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology
chemical_list: D005227:Fatty Acids