title: Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later.
abstract: OBJECTIVE
  Examine the relationship between 1- and 2-month weight loss (WL) and 8-year WL among participants enrolled in a lifestyle intervention.
  
  
  METHODS
  2,290 Look AHEAD participants (BMI: 35.65 ± 5.93 kg/m(2) ) with type 2 diabetes received an intensive behavioral WL intervention.
  
  
  RESULTS
  1- and 2-month WL were associated with yearly WL through Year 8 (P's < 0.0001). At Month 1, participants losing 2-4% and >4% had 1.62 (95% CI: 1.32, 1.98) and 2.79 (95% CI: 2.21, 3.52) times higher odds of achieving ≥5% WL at Year 4 and 1.28 (95% CI: 1.05,1.58) and 1.77 (95% CI: 1.40, 2.24) times higher odds of achieving ≥5% WL at Year 8, compared to those losing <2% initially. At Month 2, 3-6% WL resulted in greater odds of achieving ≥5% WL at Year 4 (OR = 1.85; CI: 1.48, 2.32), and >6% WL resulted in the greatest odds of achieving ≥5% WL at Year 4 (OR = 3.85; CI: 3.05, 4.88) and Year 8 (OR = 2.28; CI: 1.81, 2.89), compared to those losing <3%. Differences in adherence between WL categories were observed as early as Month 2.
  
  
  CONCLUSIONS
  1- and 2-month WL was associated with 8-year WL. Future studies should examine whether alternative treatment strategies can be employed to improve treatment outcomes among those with low initial WL.
authors.affiliation: Weight Control and Diabetes Research Center, Miriam Hospital and Brown Medical School, Providence, Rhode Island, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Unick
authors.affiliation: Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Rebecca H
authors.initials: RH
authors.lastname: Neiberg
authors.affiliation: Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Hogan
authors.affiliation: Department of Health, Behavior & Society, Johns Hopkins Bloomberg School of Public Health, and the Global Obesity Prevention Center at Johns Hopkins, Baltimore, Maryland, USA.
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Cheskin
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Gareth R
authors.initials: GR
authors.lastname: Dutton
authors.affiliation: University of Minnesota, Minneapolis, Minnesota, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Jeffery
authors.affiliation: Southwest American Indian Center, Phoenix, Arizona, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Nelson
authors.affiliation: Columbia University Medical Center, New York, New York, USA.
authors.forename: Xavier
authors.initials: X
authors.lastname: Pi-Sunyer
authors.affiliation: Arnold School of Public Health at the University of South Carolina, Columbia, South Carolina, USA.
authors.forename: Delia Smith
authors.initials: DS
authors.lastname: West
authors.affiliation: Weight Control and Diabetes Research Center, Miriam Hospital and Brown Medical School, Providence, Rhode Island, USA.
authors.forename: Rena R
authors.initials: RR
authors.lastname: Wing
mesh_terms: D000368:Aged; D001521:Behavior Therapy; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss