title: RS3PE: Clinical and Research Development.
abstract: Remitting seronegative symmetrical synovitis with pitting edema or RS3PE is a rare elderly-onset rheumatic syndrome. Although there are overlapping clinical manifestations between RS3PE, elderly-onset rheumatoid arthritis, and polymyalgia rheumatica, RS3PE has distinct characteristics. RS3PE can be associated with neoplasia and various rheumatic conditions, suggesting that it may be heterogeneous, and is considered as a paraneoplastic rheumatic disease. The pathogenesis of RS3PE may involve vascular endothelial growth factor and infection in RS3PE based upon limited data. Patients with RS3PE without concomitant malignancy respond well to small doses of glucocorticoids and carry good prognosis.
authors.affiliation: The Division of Rheumatology, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Hongbin
authors.initials: H
authors.lastname: Li
authors.forename: Roy D
authors.initials: RD
authors.lastname: Altman
authors.forename: Qingping
authors.initials: Q
authors.lastname: Yao
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D035843:Biomedical Research / Q000379:methods; D003937:Diagnosis, Differential; D004487:Edema / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D010257:Paraneoplastic Syndromes / Q000175:diagnosis; D011111:Polymyalgia Rheumatica / Q000175:diagnosis; D011379:Prognosis; D013577:Syndrome; D013585:Synovitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D005938:Glucocorticoids