title: Topical haemoglobin spray for diabetic foot ulceration.
abstract: The development and subsequent deterioration of diabetic foot ulceration (DFU) is a common occurrence across all healthcare divides, concerning all patient groups, age, gender and social environments. It increases demand on clinical resources and creates unnecessary hardship for patients. Chronic DFU is challenging to prevent and notoriously difficult to manage owing to the complex nature of the patient and the disease itself. The improvement of oxygenation to many chronic wound groups is gaining momentum across wound care; particularly in those wounds such as DFU that present with circulatory, oxygen-deficient scenarios.
  
  
  METHODS
  A descriptive evaluation was undertaken in an acute clinical setting where a spray solution containing purified haemoglobin was used in a cohort of 20 patients who presented with chronic (>12 weeks) DFU. Standard wound care was undertaken by 18 health professionals with no changes to products, devices or practice before evaluation. All wounds received the addition of the product on eight set occasions over a 4-week period and the resulting data correlated in regards to the set outcomes of wound surface area reduction, ease of use, adverse events and patient acceptability.
  
  
  RESULTS
  At 4 weeks all wounds had demonstrated positive wound reduction, there were no adverse events, all patients and clinicians found the product acceptable and easy to use. Interestingly, although not a set outcome, all wounds commenced the evaluation with wound-bed slough present and at 4 weeks 100% were deemed slough free. At a further 4-week review no patients wounds had regressed.
  
  
  CONCLUSIONS
  The incorporation of a haemoglobin spray solution within this cohort of DFU resulted in a positive improvement in wound healing and slough elimination. Further work in this area is recommended to increase the evidence.
authors.affiliation: Nurse Practitioner, Specialist in Tissue Viability, South Tees NHS Hospitals Foundation Trust.
authors.forename: Sharon Dawn
authors.initials: SD
authors.lastname: Bateman
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D017719:Diabetic Foot / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009740:Nursing Staff / Q000523:psychology; D017060:Patient Satisfaction; D014945:Wound Healing; D055815:Young Adult
chemical_list: D006454:Hemoglobins
keywords: Diabetes; Diabetic foot; Foot ulcer; Topical oxygen therapy; Wound healing