title: Neuronal response impedance mechanism implementing cooperative networks with low firing rates and μs precision.
abstract: Realizations of low firing rates in neural networks usually require globally balanced distributions among excitatory and inhibitory links, while feasibility of temporal coding is limited by neuronal millisecond precision. We show that cooperation, governing global network features, emerges through nodal properties, as opposed to link distributions. Using in vitro and in vivo experiments we demonstrate microsecond precision of neuronal response timings under low stimulation frequencies, whereas moderate frequencies result in a chaotic neuronal phase characterized by degraded precision. Above a critical stimulation frequency, which varies among neurons, response failures were found to emerge stochastically such that the neuron functions as a low pass filter, saturating the average inter-spike-interval. This intrinsic neuronal response impedance mechanism leads to cooperation on a network level, such that firing rates are suppressed toward the lowest neuronal critical frequency simultaneously with neuronal microsecond precision. Our findings open up opportunities of controlling global features of network dynamics through few nodes with extreme properties.
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Roni
authors.initials: R
authors.lastname: Vardi
authors.affiliation: Department of Physics, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Amir
authors.initials: A
authors.lastname: Goldental
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Hagar
authors.initials: H
authors.lastname: Marmari
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Haya
authors.initials: H
authors.lastname: Brama
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel ; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital Boston, MA, USA.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Stern
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel ; Department of Physics, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Shira
authors.initials: S
authors.lastname: Sardi
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel ; Department of Physics, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Pinhas
authors.initials: P
authors.lastname: Sabo
authors.affiliation: Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel ; Department of Physics, Bar-Ilan University Ramat-Gan, Israel.
authors.forename: Ido
authors.initials: I
authors.lastname: Kanter
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D003198:Computer Simulation; D004558:Electric Stimulation; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects
chemical_list: D018377:Neurotransmitter Agents
keywords: low firing rates; neural networks; neuronal response latency; neuronal temporal precision; rate code; temporal code