title: Dose- and time-dependent effects of Garcinia kola seed extract on sexual behaviour and reproductive parameters in male Wistar rats.
abstract: The aim of the present study was to investigate the effects of a crude extract of Garcinia kola on male sexual function after subchronic and chronic treatment periods at different sublethal doses. Adult male Wistar rats were treated orally with 100, 200 and 400 mg kg(-1) of a 70% ethanolic extract of G. kola daily for 56 days. Sexual behaviour studies were performed on days 28 and 50. At termination on day 56, organ weights, sperm count, reproductive hormone levels and testicular histology were assessed. Subchronic and chronic treatment of normal male rats with G. kola extract resulted in overall increase in components of libido, erection and ejaculation in treated rats - with lower doses being more efficient than the higher dose. There was a slight reduction in some components of sexual behaviour with prolonged time of treatment. G. kola treatment at all doses resulted in increased testicular weights, increased sperm count with no change in motility and increased serum testosterone levels with no change in gonadotropin levels. Gross testicular histology was not affected by treatment. We conclude that G. kola seed extract possesses potent aphrodisiac activity in male albino rats with resultant increase in sperm count and testosterone levels.
authors.affiliation: Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
authors.forename: C R
authors.initials: CR
authors.lastname: Sewani-Rusike
authors.affiliation: Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: Ralebona
authors.affiliation: Faculty of Science Engineering and Technology, Walter Sisulu University, Mthatha, South Africa.
authors.forename: B N
authors.initials: BN
authors.lastname: Nkeh-Chungag
mesh_terms: D000818:Animals; D004542:Ejaculation / Q000187:drug effects; D029763:Garcinia kola; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D010936:Plant Extracts; D013739:Testosterone
keywords: Garcinia kola; sexual behaviour; sperm; testes; testosterone