title: Effect of exercise on serum markers of muscle inflammation in Spanish Greyhounds.
abstract: OBJECTIVE
  To investigate effects of exercise on hematologic and biochemical values (especially markers of inflammation and muscle damage) in Spanish Greyhounds used for hunting without previous training.
  
  
  METHODS
  32 Spanish Greyhounds and 31 dogs of other breeds.
  
  
  METHODS
  Hematologic variables and concentrations of C-reactive protein (CRP) and other biochemical markers were compared in samples obtained from Spanish Greyhounds 24 hours after exercise (eg, a hunting race) and 2 months after exercise (ie, at rest) and from non-Spanish Greyhounds at rest. All dogs were healthy. Hematologic and biochemical analyses were performed within 24 hours after samples were obtained, and results were compared by means of a Student t test.
  
  
  RESULTS
  CRP concentration and muscle enzyme (creatine kinase, lactate dehydrogenase, and aspartate aminotransferase) activities were significantly higher and serum iron concentration was significantly lower for Spanish Greyhounds after exercise than at rest. The WBC and neutrophil counts were significantly higher after exercise then at rest. Plasma alanine transaminase activity and total protein, calcium, and phosphorus concentrations were significantly higher after exercise than at rest. Spanish Greyhounds at rest had higher RBC counts, PCVs, and hemoglobin concentrations and lower WBC, neutrophil, and lymphocyte counts, compared with values for non-Spanish Greyhounds at rest.
  
  
  CONCLUSIONS
  Exercise of Spanish Greyhounds without prior training activated an acute-phase response represented by an increase in serum CRP concentration and decrease in serum albumin and iron concentrations. These changes, along with leukocytosis and neutrophilia, were indicative of a subclinical inflammatory state in Spanish Greyhounds.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Lucas
authors.forename: Rafael
authors.initials: R
authors.lastname: Barrera
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Duque
authors.forename: Patricia
authors.initials: P
authors.lastname: Ruiz
authors.forename: Concepcion
authors.initials: C
authors.lastname: Zaragoza
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count / Q000662:veterinary; D003402:Creatine Kinase / Q000097:blood; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis; D004285:Dogs; D005260:Female; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D008297:Male; D009220:Myositis / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D010375:Pedigree; D010805:Physical Conditioning, Animal
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase; D003402:Creatine Kinase