title: Unmet Needs in the Treatment of Gastroesophageal Reflux Disease.
abstract: Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the ther-apeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, main-tenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any fu-ture development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the afore-mentioned areas of unmet need.
authors.affiliation: The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Ram
authors.identifier: http://orcid.org/0000-0002-6477-2849
authors.initials: R
authors.lastname: Dickman
authors.affiliation: The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Carla
authors.identifier: http://orcid.org/0000-0003-3900-8598
authors.initials: C
authors.lastname: Maradey-Romero
authors.affiliation: The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Rachel
authors.identifier: http://orcid.org/0000-0002-2831-4402
authors.initials: R
authors.lastname: Gingold-Belfer
authors.affiliation: The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Ronnie
authors.identifier: http://orcid.org/0000-0002-4807-3052
authors.initials: R
authors.lastname: Fass
keywords: Gastroesophageal Reflux; Heartburn; Proton Pump Inhibitors