title: Maternal and newborn infants amino acid concentrations in obese women born themselves with normal and small for gestational age birth weight.
abstract: This study was undertaken to compare amino acid concentrations in maternal and newborn infants' serum in normal pregnancy and two groups of obese women who were born themselves with normal and small for gestational age (SGA) birth weight. Maternal cholesterol, lipoproteins concentrations and maternal and infants amino acid concentrations were evaluated at the time of delivery in 28 normal pregnancies, 46 obese pregnant women with normal birth weight (Ob-AGA group) and 44 obese pregnant women born themselves SGA (Ob-SGA group). Mean birth weight of newborn infants in Ob-SGA group was significantly less than in normal and Ob-AGA groups. Cholesterol and lipoproteins were significantly elevated in obese women (more prominent in Ob-SGA group). Most amino acid concentrations and fetal-maternal amino acid gradients were significantly lower in Ob-SGA group. These data suggest significant changes in placental amino acid transport/synthetic function in obese women who were born themselves SGA.
authors.affiliation: 1Mother and Child Care Research Institute,Russian Ministry of Public Health,Yekaterinburg,Russia.
authors.forename: P B
authors.initials: PB
authors.lastname: Tsyvian
authors.affiliation: 1Mother and Child Care Research Institute,Russian Ministry of Public Health,Yekaterinburg,Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Bashmakova
authors.affiliation: 2Ural State Medical University,Yekaterinburg,Russia.
authors.forename: O P
authors.initials: OP
authors.lastname: Kovtun
authors.affiliation: 1Mother and Child Care Research Institute,Russian Ministry of Public Health,Yekaterinburg,Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Makarenko
authors.affiliation: 1Mother and Child Care Research Institute,Russian Ministry of Public Health,Yekaterinburg,Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Pestryaeva
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001053:Apolipoproteins / Q000097:blood; D001724:Birth Weight; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007236:Infant, Small for Gestational Age; D050356:Lipid Metabolism; D008297:Male; D009765:Obesity / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D055815:Young Adult
chemical_list: D000596:Amino Acids; D001053:Apolipoproteins; D002784:Cholesterol
keywords: amino acids; maternal obesity; pregnancy