title: Infant death associated with maternal methamphetamine use during pregnancy and delivery: A case report.
abstract: The case described in this report is of a male infant who was found dead in a closet. His mother delivered the infant in the kitchen, left him wrapped in a towel, and called emergency medical services 4days after the delivery. At the autopsy, the growth suggests a full-term delivery, significant pathological findings were not observed, and the infant was estimated to be stillborn. After the autopsy, the police investigation discovered that the mother used a stimulant during the pregnancy and shortly before the rupture of the membrane. Toxicological analysis showed 1.60mg/L of methamphetamine in the blood, strongly suggesting that the fetal death was associated with this acute intoxication. Thus far, only a few cases of infant deaths have been reported in association with methamphetamine intoxication. The present case showed the highest blood concentration of methamphetamine compared to the past infant cases with this intoxication.
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan. Electronic address: kentaro.sakai@jikei.ac.jp.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
authors.forename: Kimiharu
authors.initials: K
authors.lastname: Iwadate
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Maebashi
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
authors.forename: Sari
authors.initials: S
authors.lastname: Matsumoto
authors.affiliation: Department of Forensic Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
authors.forename: Shojiro
authors.initials: S
authors.lastname: Takasu
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000097:blood; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008297:Male; D008431:Maternal-Fetal Exchange; D008694:Methamphetamine / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D008694:Methamphetamine; D000661:Amphetamine
keywords: Autopsy; Drug abuse; Infant; Methamphetamine; Pregnancy; Toxicology