title: Macular thickness measured by optical coherence tomography correlates with proteinuria in pre-eclampsia.
abstract: OBJECTIVE
  Pre-eclampsia is associated with ocular changes. The aim of this study was to examine the macular changes of patients with early-onset severe pre-eclampsia using optical coherence tomography (OCT).
  
  
  METHODS
  This prospective study was performed at Tygerberg Academic Hospital, a secondary and tertiary referral centre in Cape Town, South Africa. Twenty women with early onset pre-eclampsia and 20 women without hypertensive or vascular complications, matched for gestational age, were examined before and after delivery.
  
  
  RESULTS
  There was a trend showing a positive correlation between increased central retinal thickness and increasing proteinuria in patients with pre-eclampsia antepartum (left eye r=0.52, p=0.04) and postpartum (left eye r=0.60, p=0.01). A positive correlation between average central 1mm and proteinuria was noted antepartum (left eye r=0.63, p=0.01) and postpartum (right eye r=0.52, p=0.03). There were no significant correlations between blood pressure and any of the retinal parameters. Two of the 23 patients with pre-eclampsia developed serous retinal detachments, both of which resolved completely postpartum.
  
  
  CONCLUSIONS
  Macular thickness parameters measured using OCT correlated with the degree of proteinuria in pre-eclampsia. These changes reversed soon after delivery.
authors.affiliation: Department of Ophthalmology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, Western Cape, South Africa. Electronic address: goodingcaro@gmail.com.
authors.forename: Caroline
authors.initials: C
authors.lastname: Gooding
authors.affiliation: Department of Obstetrics and Gynaecology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, Western Cape, South Africa.
authors.forename: David R
authors.initials: DR
authors.lastname: Hall
authors.affiliation: Centre for Statistical Consultation, Stellenbosch University, Stellenbosch, Western Cape, South Africa.
authors.forename: Martin
authors.initials: M
authors.lastname: Kidd
authors.affiliation: Department of Ophthalmology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, Western Cape, South Africa.
authors.forename: Ari
authors.initials: A
authors.lastname: Ziskind
keywords: CSCR; Central Serous Chorioretinopathy; OCT; Optical Coherence Tomography; Optical coherence tomography; Pre-eclampsia; Proteinuria; Retinal thickness