title: Metal-Free Radical [2+2+1] Carbocyclization of Benzene-Linked 1,n-Enynes: Dual C(sp(3))-H Functionalization Adjacent to a Heteroatom.
abstract: A new metal-free oxidative radical [2+2+1] carbocyclization of benzene-linked 1,n-enynes with two C(sp(3))-H bonds adjacent to the same heteroatom is described. This method achieves two C(sp(3))-H oxidative functionalizations and an annulation, thus providing efficient and general access to a variety of fused five-membered carbocyclic hydrocarbons.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Ming
authors.initials: M
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Xuan-Hui
authors.initials: XH
authors.lastname: Ouyang
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China).
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (China). jhli@hnu.edu.cn.|State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000 (China). jhli@hnu.edu.cn.
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D005609:Free Radicals; D006571:Heterocyclic Compounds; D010545:Peroxides
keywords: carbocycles; enynes; heterocycles; peroxides; radicals