title: SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique.
abstract: BACKGROUND
  Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.
  
  
  OBJECTIVE
  Study of SULF1 gene polymorphism with fetus failure in in vitro fertilization (IVF) technique.
  
  
  METHODS
  We studied one common (minor allele frequency >0.05) regulatory SNP, rs6990375, with polymerase chain reaction and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.
  
  
  RESULTS
  We found that rs6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).
  
  
  CONCLUSIONS
  These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.
authors.affiliation: Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Eskandar
authors.initials: E
authors.lastname: Taghizadeh
authors.affiliation: Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Kalantar
authors.affiliation: Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Mahdian
authors.affiliation: Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Sheikhha
authors.affiliation: Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Farashahi-Yazd
authors.affiliation: Department of Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Ghasemi
authors.affiliation: Pasteur Institute of Iran, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Shahbazi
keywords: Polymerase chain reaction; Restriction endonucleases; Restriction fragment length Polymorphysm; SULF1 gene; Single nucleotide polymorphism; rs6990375