title: Role of high sensitivity C-reactive protein and other risk factors in intracranial and extracranial artery occlusion in patients with ischaemic stroke.
abstract: OBJECTIVE
  A retrospective case-control study to identify stroke-associated risk factors and quantify serum C-reactive protein in patients with ischaemic stroke, with or without intracranial and/or extracranial artery occlusion (IEAO).
  
  
  METHODS
  Patients with ischaemic stroke and internal carotid artery occlusion (ICAO), middle cerebral artery occlusion (MCAO), ICAO + MCAO, or no IEAO (control patients) were retrospectively recruited. Data regarding stroke-associated risk factors were retrieved from medical records. High sensitivity (hs)-CRP was quantified within 3 days of hospital admission.
  
  
  RESULTS
  Patients with ICAO (n = 89), MCAO (n = 74) and ICAO + MCAO (n = 29) had significantly higher serum hs-CRP concentrations, and were significantly more likely to have coronary heart disease, a history of stroke, and more than three stroke-associated risk factors than control patients (n = 84).
  
  
  CONCLUSIONS
  Coronary heart disease and a history of stroke are risk factors for ischaemic stroke with IEAO. Hs-CRP may be used as a marker for IEAO.
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xie
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Deng
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Liu
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Ji-mei
authors.initials: JM
authors.lastname: Li
authors.affiliation: Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China ybzhangcn@sina.com.
authors.forename: Yong-bo
authors.initials: YB
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism*; D002539:Cerebral Arterial Diseases / Q000378:metabolism*; D002536:Cerebral Arteries / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000378:metabolism*
chemical_list: D002097:C-Reactive Protein
keywords: Ischaemic stroke; high-sensitivity C-reactive protein; internal carotid artery occlusion; middle cerebral artery occlusion; risk factors