title: Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation.
abstract: Scaffolds with tunable mechanical and topological properties fabricated by templated-fused deposition modeling promote increased osteogenic differentiation of bone marrow stem cells with increasing substrate modulus and decreasing pore size. These findings guide the rational design of cell-responsive scaffolds that recapitulate the bone microenvironment for repair of bone damaged by trauma or disease.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
authors.forename: Ruijing
authors.initials: R
authors.lastname: Guo
authors.affiliation: Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
authors.forename: Sichang
authors.initials: S
authors.lastname: Lu
authors.affiliation: Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Page
authors.affiliation: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.|Center for Bone Biology, Division of Clinical Pharmacology, Nashville, TN, 37232, USA.|Division of Clinical Phamacology, Vanderbilt University, Nashville, TN, 37235, USA.|Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
authors.forename: Alyssa R
authors.initials: AR
authors.lastname: Merkel
authors.affiliation: Agilent Technologies, Chandler, AZ, USA.
authors.forename: Sandip
authors.initials: S
authors.lastname: Basu
authors.affiliation: Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, 37212, USA.|Center for Bone Biology, Division of Clinical Pharmacology, Nashville, TN, 37232, USA.|Division of Clinical Phamacology, Vanderbilt University, Nashville, TN, 37235, USA.|Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Sterling
authors.affiliation: Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37212, USA.|Center for Bone Biology, Division of Clinical Pharmacology, Nashville, TN, 37232, USA.|Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Guelcher
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D059630:Mesenchymal Stem Cells; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: fused deposition modeling; modulus; osteogenic differentiation; pore size; scaffolds