title: Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).
abstract: In this review we discuss recent progress in targeting the protein-protein interactions made by oncogenic transcription factors. We particularly focus on the challenges posed by the prevalence of intrinsically disordered regions in this class of protein and the strategies being used to overcome them.
authors.affiliation: Department of Microbiology, Cell and Tumour Biology, and Science for Life Laboratory, Karolinska Institutet, Tomtebodavägen 23A, Stockholm 171 65, Sweden.
authors.forename: Susan
authors.initials: S
authors.lastname: Sammak
authors.affiliation: Department of Microbiology, Cell and Tumour Biology, and Science for Life Laboratory, Karolinska Institutet, Tomtebodavägen 23A, Stockholm 171 65, Sweden. Electronic address: giovanna.zinzalla@ki.se.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Zinzalla
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D064267:Intrinsically Disordered Proteins; D014157:Transcription Factors
keywords: Anticancer therapy; HIF-1; Intrinsically disordered proteins; Protein–protein interactions; STAT3; Transcription factors; c-MYC; β-catenin