title: [ANALYSIS OF MUTATION IN CODON 531 rpoB GENE, ASSOCIATED WITH RIFAMPICIN RESISTANCE AMONG SAMPLES OF MYCOBACTERIUM TUBERCULOSIS THAT WAS ISOLATED FROM THE PATIENTS].
abstract: In the conditions of high relative density of multidrug resistant tuberculosis in Ukraine, rapid diagnostics of M. tuberculosis susceptibility to antituberculous drugs is the important tool in treatment of patients with lung tuberculosis. 78 patients with lung TB that were treated in TB dispensary in Kharkiv during 2004-2005 years were analyzed. Mutations in 531 codon of rpoB gene of isolates M. tuberculosis were studied. Among 48 (61.5%) resistant isolates of M tuberculosis according to phenotypic method, mutations were found only at 29 (60.4%) isolates. Among 30 (38.5%) phenotypic sensitive M. tuberculosis isolates only 1 (3.3%) isolate had mutation in rpoB gene M. tuberculosis.
authors.forename: P I
authors.initials: PI
authors.lastname: Poteĭko
authors.forename: A A
authors.initials: AA
authors.lastname: Liashenko
authors.forename: L V
authors.initials: LV
authors.lastname: Lebed'
authors.forename: M A
authors.initials: MA
authors.lastname: Dymova
authors.forename: V S
authors.initials: VS
authors.lastname: Kryt'ko
authors.forename: M L
authors.initials: ML
authors.lastname: Filipenko
authors.forename: D A
authors.initials: DA
authors.lastname: Kashuba
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics*; D003062:Codon; D012321:DNA-Directed RNA Polymerases; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009161:Mycobacterium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D003062:Codon; C505805:rpoB protein, Mycobacterium tuberculosis; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin