title: Synthesis of bis(indolyl)methanes Catalyzed by Triethylborane.
abstract: Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. VibrindoleA (5)and bis(indolyl)methanes derivatives16and18were synthesized using this methodology. Compound16is an intermediary in the synthesis of the natural bisindoles arsindolineB (2)and streptindole(6). The structure of vibrindoleA (5)was unequivocally confirmed by a single crystal X-ray diffraction analysis.
authors.affiliation: Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca- Tulancingo Km. 4.5, Mineral de La Reforma, Hidalgo, CP 42076, Mexico, ; bInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ed.B-1, C.U., Morelia, Michoacán, 58030, México.
authors.forename: J Pablo García
authors.initials: JP
authors.lastname: Merinos
authors.affiliation: Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca- Tulancingo Km. 4.5, Mineral de La Reforma, Hidalgo, CP 42076, Mexico.
authors.forename: Heraclio López
authors.initials: HL
authors.lastname: Ruíz
authors.affiliation: bInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Ed.B-1, C.U., Morelia, Michoacán, 58030, México.
authors.forename: Yliana
authors.initials: Y
authors.lastname: López
authors.affiliation: Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca- Tulancingo Km. 4.5, Mineral de La Reforma, Hidalgo, CP 42076, Mexico.
authors.forename: Susana Rojas
authors.initials: SR
authors.lastname: Lima
keywords: Arsindoline B; bis(indolyl)methanes; indole; streptindole; triethylborane