title: Serous Tubal Intraepithelial Carcinoma (STIC)-like Lesions Arising in Ovarian Serous Cystadenofibroma: Report of 2 Cases.
abstract: Recent studies have demonstrated that most so-called ovarian high-grade serous carcinomas are likely to arise from the epithelium of the distal fimbrial portion of the fallopian tube from a precursor lesion known as serous tubal intraepithelial carcinoma (STIC). We report 2 cases in patients aged 56 and 71 of lesions morphologically identical to STIC (referred to as STIC-like lesions) arising from the benign ciliated epithelium of ovarian serous cystadenofibromas. In 1 case, 2 glands within the serous cystadenofibroma exhibited high-grade nuclear atypia and mitotic activity and in the other similar changes were multifocal. No invasion of the stroma was seen. In both cases, the STIC-like lesion exhibited aberrant "mutation-type" staining with p53 (1 diffuse intense positivity, 1 null pattern). As far as we are aware, a STIC-like lesion involving the epithelium of a benign ovarian serous neoplasm has not been reported previously. Both patients were followed up without adjuvant treatment. One case is recent, and follow-up in the other patient is uneventful at 12 mo.
authors.affiliation: Departments of Gynaecological Oncology (E.C.) Pathology (W.G.M.), Belfast Health and Social Care Trust, Belfast Department of Pathology, Craigavon Area Hospital, Craigavon (R.C.) Department of Pathology, Maidstone & Tunbridge Wells NHS Trust, Maidstone (G.R.), United Kingdom.
authors.forename: Elaine
authors.initials: E
authors.lastname: Craig
authors.forename: Rosemary
authors.initials: R
authors.lastname: Clarke
authors.forename: Gary
authors.initials: G
authors.lastname: Rushton
authors.forename: W Glenn
authors.initials: WG
authors.lastname: McCluggage
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002278:Carcinoma in Situ / Q000473:pathology*; D062625:Cystadenofibroma / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor