title: Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivatives.
abstract: In this paper, we describe the synthesis and pharmacological evaluation of a series of 4-aminoquinolines. The compounds were characterised and tested in models of pain and inflammation, using the writhing test with acetic acid, formalin test, peritonitis test by zymosan and arthritis test with Freund's adjuvant complete assay. The results revealed that all of the 4-aminoquinolines that were prepared promoted anti-nociceptive activity as well as acute and chronic anti-inflammatory effects, with marked activity in the derivates labelled with BAQ and 7-CF3-MAQ. After 7 days of treatment, 7-CF3-MAQ did not induce significant hepatotoxicity, gastrotoxicity or nephrotoxicity.
authors.affiliation: GCaR-Grupo de Catálise e Reatividade Química, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Raquel
authors.initials: R
authors.lastname: de Meneses Santos
authors.affiliation: GCaR-Grupo de Catálise e Reatividade Química, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Pooline Rocha
authors.initials: PR
authors.lastname: Barros
authors.affiliation: GCaR-Grupo de Catálise e Reatividade Química, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Janaína Heberle
authors.initials: JH
authors.lastname: Bortoluzzi
authors.affiliation: GCaR-Grupo de Catálise e Reatividade Química, Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, AL, Brazil. Electronic address: mrm@qui.ufal.br.
authors.forename: Mario Roberto
authors.initials: MR
authors.lastname: Meneghetti
authors.affiliation: LaFI-Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Yolanda Karla Cupertino
authors.initials: YKC
authors.lastname: da Silva
authors.affiliation: LaFI-Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Amanda Evelyn
authors.initials: AE
authors.lastname: da Silva
authors.affiliation: LaFI-Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: da Silva Santos
authors.affiliation: LaFI-Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil. Electronic address: suzana.magna@gmail.com.
authors.forename: Magna Suzana
authors.initials: MS
authors.lastname: Alexandre-Moreira
mesh_terms: D000634:Aminoquinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy / Q000209:etiology; D005620:Freund's Adjuvant / Q000633:toxicity; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010147:Pain Measurement; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D015054:Zymosan / Q000633:toxicity
chemical_list: D000634:Aminoquinolines; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005620:Freund's Adjuvant; D015054:Zymosan; C001920:4-aminoquinoline
keywords: Aminoquinolines; Anti-inflammatory; Anti-nociceptive; Rheumatism; Toxicity