title: Meta-analysis of osteoporosis: fracture risks, medication and treatment.
abstract: Osteoporosis is a brittle bone disease that can cause fractures mostly in older men and women. Meta-analysis is the statistical method which is applied in the frame work for the assessment of results obtained from various research studies conducted in several years. A meta-analysis of osteoporotic fracture risk with medication non-adherence has been described to assess the bone fracture risk among patients non-adherent versus adherent to therapy for osteoporosis by many researchers. Osteoporosis therapy reduces the risk of fracture in clinical trials, and real-world adherence to therapy which is suboptimal and can reduce the effectiveness of intervention. The methods of Medline, Embase, and CINAHL were literature searched for these observational studies from year 1998 to 2009, and up to 2015. The results of meta-analysis of osteoporosis research on fractures of postmenopausal women and men are presented. The use of bisphosphonate therapy for osteoporosis has been described with other drugs. The authors, design, studies (women %), years (data), follow-up (wks), fractures (types), and compliance or persistence results from years 2004 to 2009 from are shown in a brief table. The meta-analysis studies have been reviewed from other researchers on osteoporosis and fractures, medications and treatments.
authors.affiliation: Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: L-H
authors.initials: LH
authors.lastname: Yang
authors.forename: X-C
authors.initials: XC
authors.lastname: Kong
authors.forename: L-K
authors.initials: LK
authors.lastname: An
authors.forename: R
authors.initials: R
authors.lastname: Wang
mesh_terms: D000368:Aged; D000375:Aging; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008019:Life Style; D055118:Medication Adherence; D010024:Osteoporosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000628:therapy; D058866:Osteoporotic Fractures / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents