title: The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury.
abstract: This study investigated the effects of perturbed cerebral blood flow (CBF) and cerebrovascular reactivity (CR) on relaxation time constant (T2), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and behavioral scores at 1 and 3 hours, 2, 7, and 14 days after traumatic brain injury (TBI) in rats. Open-skull TBI was induced over the left primary forelimb somatosensory cortex (N=8 and 3 sham). We found the abnormal areas of CBF and CR on days 0 and 2 were larger than those of the T2, ADC, and FA abnormalities. In the impact core, CBF was reduced on day 0, increased to 2.5 times of normal on day 2, and returned toward normal by day 14, whereas in the tissue surrounding the impact, hypoperfusion was observed on days 0 and 2. CR in the impact core was negative, most severe on day 2 but gradually returned toward normal. T2, ADC, and FA abnormalities in the impact core were detected on day 0, peaked on day 2, and pseudonormalized by day 14. Lesion volumes peaked on day 2 and were temporally correlated with forelimb asymmetry and foot-fault scores. This study quantified the effects of perturbed CBF and CR on structural magnetic resonance imaging and behavioral readouts.
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Long
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.|Departments of Cellular and Structure Biology, University of Texas Health Science Center, San Antonio, Texas, USA.|Department of Neurology, University of Texas Health Science Center, Houston, Texas, USA.
authors.forename: Lora T
authors.initials: LT
authors.lastname: Watts
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Eric R
authors.initials: ER
authors.lastname: Muir
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Shiliang
authors.initials: S
authors.lastname: Huang
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Boggs
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Suri
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.|Department of Neurology, University of Texas Health Science Center, Houston, Texas, USA.|Department of Opthalmology, University of Texas Health Science Center, San Antonio, Texas, USA.|South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Timothy Q
authors.initials: TQ
authors.lastname: Duong
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001930:Brain Injuries / Q000473:pathology* / Q000523:psychology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000473:pathology* / Q000523:psychology*; D056324:Diffusion Tensor Imaging; D004525:Efferent Pathways / Q000473:pathology; D005552:Forelimb / Q000294:innervation; D006935:Hypercapnia / Q000473:pathology / Q000523:psychology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000473:pathology
chemical_list: D009419:Nerve Tissue Proteins