title: Outcomes and Treatment of Lumbosacral Spinal Tuberculosis: A Retrospective Study of 53 Patients.
abstract: A retrospective clinic study.
  
  
  OBJECTIVE
  To evaluate the efficacy of conservative and surgical treatment for lumbosacral tuberculosis.
  
  
  METHODS
  This study retrospectively reviewed 53 patients with lumbosacral tuberculosis who were treated in our institution between January 2005 and January 2011. There were 29 males and 24 females with average ages of 37.53 ± 17.28 years (range 6-72 years). 11 patients were given only anti-TB drugs; the remainder underwent anterior debridement, interbody fusion with and without instrumentation, or one-stage anterior debridement combined with posterior instrumentation. Outcome data for these patients included neurologic status, lumbosacral angle, erythrocyte sedimentation rate value(ESR) and C-reactive protein value(CRP) were assessed before and after treatment.
  
  
  RESULTS
  The mean lumbosacral angles were 23.00°± 2.90° in the conservatively treated patients and 22.36°± 3.92o in the surgically treated patients. At the final follow-up, this had improved to 24.10o ± 2.96° in the conservatively treated patients and 28.13° ± 1.93° in the surgically treated patients (all P < 0.05). There were statistically significant differences before and after treatment in terms of ESR and CRP (all P < 0.05). All patients achieved bone fusion. The mean follow-up period was 32.34 ± 8.13 months (range 18 to 55 months). The neurological deficit did not worsen in any of the patients.
  
  
  CONCLUSIONS
  It has been proven that conservative and surgical treatments are safe and effective and produce good clinical outcomes for patients with lumbosacral tuberculosis. The advantages of operation include thoroughness of debridement, decompression of the spinal cord, and adequate spinal stabilization.
authors.affiliation: Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Tenglong
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Jinming
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Maolin
authors.initials: M
authors.lastname: He
authors.affiliation: Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.affiliation: Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Mitra
authors.initials: M
authors.lastname: Fowdur
authors.affiliation: Department of Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuang Yong Rd, Nanning, Guangxi, China; Guangxi Key Laboratory of Regenerative Medicine, Nanning, Guangxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D001416:Back Pain; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000096:biosynthesis; D002648:Child; D003646:Debridement; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D012447:Sacrum / Q000473:pathology; D013123:Spinal Fusion; D016896:Treatment Outcome; D014399:Tuberculosis, Spinal / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D002097:C-Reactive Protein