title: Biotransformation and stability of antibody-drug conjugates: payload metabolism and linker cleavage delineation.
authors.affiliation: Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063, USA.
authors.forename: Vangipuram S
authors.initials: VS
authors.lastname: Rangan
authors.affiliation: Bioanalytical Sciences-Biologics, Bristol-Myers Squibb, Lawrenceville, NJ, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Myler
authors.affiliation: Bioanalytical Sciences-Biologics, Bristol-Myers Squibb, Lawrenceville, NJ, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Kozhich
authors.affiliation: Bioanalytical Sciences-LCMS, Bristol-Myers Squibb, Lawrenceville, NJ, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Global Manufacturing & Supply/Biologics Development & Operations, Hopewell, NJ, USA.
authors.forename: Renee
authors.initials: R
authors.lastname: Randazzo
authors.affiliation: Biologics Discovery California, Bristol-Myers Squibb, Redwood City, CA 94063, USA.
authors.forename: Shrikant
authors.initials: S
authors.lastname: Deshpande
mesh_terms: D000818:Animals; D001711:Biotransformation; D002623:Chemistry Techniques, Analytical / Q000379:methods; D004355:Drug Stability; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D055550:Protein Stability
chemical_list: D018796:Immunoconjugates; D004364:Pharmaceutical Preparations
keywords: active antibody–drug conjugates; bioanalytical assay; biotransformation; conjugated antibody; conjugated payload; drug to antibody ratio; linker cleavage; unconjugated payload