title: Two Cases of Pathological Complete Response to Neoadjuvant Chemoradiation Therapy in Pancreatic Cancer.
abstract: Neoadjuvant chemoradiation therapy (NACRT) is increasingly used in patients with a potentially or borderline resectable pancreatic ductal adenocarcinoma (PDA) and it has been shown to improve survival and reduce locoregional metastatic disease. It is rare for patients with PDA to have a pathological complete response (pCR) to NACRT, but such patients reportedly have a good prognosis. We report the clinicopathological findings of two cases of pCR to NACRT in PDA. Both patients underwent pancreatectomy after NACRT (5-fluorouracil, mitomycin C, cisplatin, and radiation). Neither had residual invasive carcinoma and both showed extensive fibrotic regions with several ducts regarded as having pancreatic intraepithelial neoplasia 3/carcinoma in situ in their post-therapy specimens. It is noteworthy that both patients had a history of a second primary cancer. They both had comparatively good outcomes: one lived for 9 years after the initial pancreatectomy and the other is still alive without recurrence after 2 years.
authors.affiliation: Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujii-Nishimura
authors.forename: Ryo
authors.initials: R
authors.lastname: Nishiyama
authors.forename: Minoru
authors.initials: M
authors.lastname: Kitago
authors.forename: Yohei
authors.initials: Y
authors.lastname: Masugi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Ueno
authors.forename: Koichi
authors.initials: K
authors.lastname: Aiura
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Miho
authors.initials: M
authors.lastname: Kawaida
authors.forename: Yuta
authors.initials: Y
authors.lastname: Abe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shinoda
authors.forename: Osamu
authors.initials: O
authors.lastname: Itano
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tanimoto
authors.forename: Michiie
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil