title: V(D)J Recombination: Mechanism, Errors, and Fidelity.
abstract: V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we review the basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA rearrangements, and the types of aberrant events uncovered in recent genomewide analyses of lymphoid neoplasms.
authors.affiliation: Department of Pathology and Laboratory Medicine and the Center for Personalized Diagnostics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
authors.forename: David B
authors.initials: DB
authors.lastname: Roth
mesh_terms: D000818:Animals; D014644:Genetic Variation; D006801:Humans; D011946:Receptors, Antigen / Q000235:genetics*; D060152:V(D)J Recombination; D045567:VDJ Recombinases / Q000378:metabolism
chemical_list: D011946:Receptors, Antigen; D045567:VDJ Recombinases