title: The predominant cluster of CRF01_AE circulating among newly diagnosed HIV-1-positive people in Anhui Province, China.
abstract: CRF01_AE, which has led a new epidemic in many provinces in China and has displayed complex characteristics, has now evolved into multiple clusters in China. Some clusters often circulate in specific regions or among specific risk populations in China. To better determine the characteristics of CRF01_AE circulating in Anhui Province, we analyzed CRF01_AE based on gag and pol sequences. Our results showed that CRF01_AE circulating in Anhui Province was clearly divided into three clusters. Cluster 1 covered 90% of the sequences in all CRF01_AE. Among Cluster 1, the sequences from men who have sex with men (MSM) and heterosexuals were interwoven. It is suggested that MSM may play a bridge role in transmitting HIV-1 among the different risk groups.
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Jianjun
authors.initials: J
authors.lastname: Wu
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Yuelan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: 2 Shanghai Municipal Center for Disease Control and Prevention , Shanghai City, China .
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.affiliation: 3 Chinese Center for Disease Control and Prevention , Beijing City, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: 3 Chinese Center for Disease Control and Prevention , Beijing City, China .
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Yizu
authors.initials: Y
authors.lastname: Qin
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Aiwen
authors.initials: A
authors.lastname: Liu
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Lifeng
authors.initials: L
authors.lastname: Miao
authors.affiliation: 4 Anhui Medical University , Hefei City, Anhui Province, China .
authors.forename: Lili
authors.initials: L
authors.lastname: Cui
authors.affiliation: 1 Anhui Provincial Center for Disease Control and Prevention , Hefei City, Anhui Province, China .
authors.forename: Bin
authors.initials: B
authors.lastname: Su
authors.affiliation: 5 Jiangsu Provincial Center for Disease Control and Prevention , Nanjing City, Jiangsu Province, China .
authors.forename: Hongxiong
authors.initials: H
authors.lastname: Guo
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D015750:Genes, gag; D015751:Genes, pol; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA