title: Yvh1 protein phosphatase is required for pre-autophagosomal structure formation after TORC1 inactivation.
abstract: The pre-autophagosomal structure (PAS) is a putative site for autophagosome formation in budding yeast. Upon nutrient depletion or rapamycin treatment, target of rapamycin complex 1 (TORC1) becomes inactive, inducing PAS formation and autophagy. Here, we show that Yvh1 phosphatase is critical for PAS formation, but not autophagy induction, after TORC1 inactivation.
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Akter M S T
authors.initials: AM
authors.lastname: Yeasmin
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
authors.forename: Talukdar Muhammad
authors.initials: TM
authors.lastname: Waliullah
authors.affiliation: b Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kondo
authors.affiliation: a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.|b Faculty of Science , Shizuoka University , Shizuoka , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ushimaru
mesh_terms: D001343:Autophagy; D054637:Dual-Specificity Phosphatases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D010588:Phagosomes / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000201:enzymology / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins; C561842:TORC1 protein complex, S cerevisiae; D014157:Transcription Factors; D054637:Dual-Specificity Phosphatases; C121559:YVH1 protein, S cerevisiae
keywords: Saccharomyces cerevisiae; Yvh1; autophagy; pre-autophagosomal structure (PAS); target of rapamycin complex 1 (TORC1)