title: Vascular endothelial growth factor polymorphisms and lung cancer risk.
abstract: The VEGF polymorphisms has been implicated in the susceptibility to lung cancer, but the results are not conclusive. The aim of this study is to investigate the association between the VEGF polymorphisms and the risk of lung cancer by meta-analysis. We searched PubMed, Embase, CNKI and Wanfang databases. A total of 7 case-control studies were included in this meta-analysis. We found that VEGF rs833061 polymorphism showed no significant association with lung cancer risk. Subgroup analysis on race suggested that CC genotype was significantly associated with lung cancer risk in Asian population. We found that VEGF rs699947 polymorphism showed significant association with lung cancer risk. Subgroup analysis on race showed that VEGF rs699947 polymorphism increased lung cancer risk in Asians. In conclusion, this meta-analysis suggested that the VEGF rs699947 is associated with increased risk of lung cancer.
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Fan
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Caipeng
authors.initials: C
authors.lastname: Lei
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Qiao
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Hongduo
authors.initials: H
authors.lastname: Jiao
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Leizhen
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Microsurgical Ward Section, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Cui
authors.affiliation: Department of Oncology Surgery, The First Affiliated Hospital of Henan University of Science and Technology Luoyang 471003, Henan, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Chen
keywords: Lung cancer; VEGF; meta-analysis