title: Grip strength comparison in immune-mediated neuropathies: Vigorimeter vs. Jamar.
abstract: The Jamar dynamometer and Vigorimeter have been used to assess grip strength in immune-mediated neuropathies, but have never been compared to each other. Therefore, we performed a comparison study between these two devices in patients with immune-mediated neuropathies. Grip strength data were collected in 102 cross-sectional stable and 163 longitudinal (new diagnoses or changing condition) patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), gammopathy-related polyneuropathy (MGUSP), and multifocal motor neuropathy (MMN). Stable patients were assessed twice (validity/reliability studies). Longitudinal patients were assessed 3-5 times during 1 year. Responsiveness comparison between the two tools was examined using combined anchor-/distribution-based minimum clinically important difference (MCID) techniques. Patients were asked to indicate their preference for the Jamar or Vigorimeter. Both tools correlated highly with each other (ρ = 0.86, p < 0.0001) and showed good intra-class correlation coefficients (Jamar [Right/Left hands]: ICC 0.997/0.96; Vigori: ICC 0.95/0.98). Meaningful changes were comparable between the two instruments, being higher in GBS compared to CIDP patients. In MGUSP/MMN poor responsiveness was seen. Significant more patients preferred the Vigorimeter. In conclusion, validity, reliability, and responsiveness aspects were comparable between the Jamar dynamometer and Vigorimeter. However, based on patients' preference, the Vigorimeter is recommended in future studies in immune-mediated neuropathies.
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Thomas H P
authors.initials: TH
authors.lastname: Draak
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Mariëlle H J
authors.initials: MH
authors.lastname: Pruppers
authors.affiliation: Department of Neurology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Sonja I
authors.initials: SI
authors.lastname: van Nes
authors.affiliation: Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Els K
authors.initials: EK
authors.lastname: Vanhoutte
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Mayienne
authors.initials: M
authors.lastname: Bakkers
authors.affiliation: Department of Neurology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Gorson
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands.
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: Van der Pol
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lewis
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands.
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Notermans
authors.affiliation: Department of Neurological Sciences, Milan University, Humanitas Clinical Institute, Milan, Italy.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nobile-Orazio
authors.affiliation: Department of Neurology, Hôpital de la Salpêtrière, Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Léger
authors.affiliation: Neuromuscular Reference Centre UCL St-Luc, University Hospitals St-Luc, Brussels, Belgium.
authors.forename: Peter Y K
authors.initials: PY
authors.lastname: Van den Bergh
authors.affiliation: Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.affiliation: Department of Neurology, Toronto General Hospital, Toronto, Canada.
authors.forename: Vera
authors.initials: V
authors.lastname: Bril
authors.affiliation: Department of Neurology, Toronto General Hospital, Toronto, Canada.
authors.forename: Hans
authors.initials: H
authors.lastname: Katzberg
authors.affiliation: Department of Neurology, Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: Michael P T
authors.initials: MP
authors.lastname: Lunn
authors.affiliation: Department of Neurology, Centre de Référence des Maladies Neuromusculaires et de la SLA, Hôpital de La Timone, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Pouget
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Anneke J
authors.initials: AJ
authors.lastname: van der Kooi
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands.
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
authors.affiliation: Department of Neurology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Cornblath
authors.affiliation: Department of Neurology, London Health Science Center, London, Canada.
authors.forename: Angelika F
authors.initials: AF
authors.lastname: Hahn
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Catharina G
authors.initials: CG
authors.lastname: Faber
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.|Department of Neurology, Spaarne Hospital, Hoofddorp, The Netherlands.
authors.forename: Ingemar S J
authors.initials: IS
authors.lastname: Merkies
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D053581:Muscle Strength Dynamometer; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000503:physiopathology*; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric
keywords: Jamar dynamometer; Vigorimeter; grip strength; responsiveness comparison