title: [BCL1 POLYMORPHISM OF GLUCOCORTICOID RECEPTOR GENE AND RESPIRATORY DISEASES].
abstract: The article analyses the results of investigating the connection between BCL1-polymorphism of glucocorticoid receptor gene and respiratory diseases. Its role in increasing sensitivity to glucocorticoids is proved here. The authors investigated the association of Bcl1 polymorphism with predisposition to bronchial asthma, chronic obstructive pulmonary disease, with the nicotine addiction degree and with progressing disorders of pulmonary function in cystic fibrosis.
authors.forename: L N
authors.initials: LN
authors.lastname: Prystupa
authors.forename: V Yu
authors.initials: VY
authors.lastname: Garbuzova
authors.forename: V V
authors.initials: VV
authors.lastname: Kmyta
mesh_terms: D000483:Alleles; D001249:Asthma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012307:Risk Factors; D014029:Tobacco Use Disorder / Q000503:physiopathology / Q000523:psychology
chemical_list: D005938:Glucocorticoids; C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid