title: Synthesis of tripodal catecholates and their immobilization on zinc oxide nanoparticles.
abstract: A common approach to generate tailored materials and nanoparticles (NPs) is the formation of molecular monolayers by chemisorption of bifunctional anchor molecules. This approach depends critically on the choice of a suitable anchor group. Recently, bifunctional catecholates, inspired by mussel-adhesive proteins (MAPs) and bacterial siderophores, have received considerable interest as anchor groups for biomedically relevant metal surfaces and nanoparticles. We report here the synthesis of new tripodal catecholates as multivalent anchor molecules for immobilization on metal surfaces and nanoparticles. The tripodal catecholates have been conjugated to various effector molecules such as PEG, a sulfobetaine and an adamantyl group. The potential of these conjugates has been demonstrated with the immobilization of tripodal catecholates on ZnO NPs. The results confirmed a high loading of tripodal PEG-catecholates on the particles and the formation of stable PEG layers in aqueous solution.
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Pharmaceutical and Medicinal Chemistry, Bundesstr. 45, 20146 Hamburg, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Klitsche
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Pharmaceutical and Medicinal Chemistry, Bundesstr. 45, 20146 Hamburg, Germany.
authors.forename: Julian
authors.initials: J
authors.lastname: Ramcke
authors.affiliation: IENI-CNR, Department of Chemical Sciences, University of Padova, INSTM, Via Marzolo 1, 35131 Padova, Italy.
authors.forename: Julia
authors.initials: J
authors.lastname: Migenda
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Physical Chemistry, Grindelallee 117, 20146 Hamburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hensel
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Physical Chemistry, Grindelallee 117, 20146 Hamburg, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Vossmeyer
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Physical Chemistry, Grindelallee 117, 20146 Hamburg, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Weller
authors.affiliation: IENI-CNR, Department of Chemical Sciences, University of Padova, INSTM, Via Marzolo 1, 35131 Padova, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gross
authors.affiliation: Department of Chemistry, University of Hamburg, Institute of Pharmaceutical and Medicinal Chemistry, Bundesstr. 45, 20146 Hamburg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maison
keywords: ZnO nanoparticles; bifunctional anchors; catecholates; multivalency; poly(ethylene glycol)