title: Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro.
abstract: Specific JNK and p53 inhibitors stimulated the formation of fibroblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia, zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: E Yu
authors.initials: EY
authors.lastname: Sherstoboev
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Burmina
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000818:Animals; D052160:Benzothiazoles / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology*; D006918:Hydroxyurea; D066298:In Vitro Techniques; D048670:MAP Kinase Kinase 4 / Q000037:antagonists & inhibitors*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction / Q000502:physiology*; D018709:Statistics, Nonparametric; D014050:Toluene / Q000031:analogs & derivatives* / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors*
chemical_list: D052160:Benzothiazoles; D047428:Protein Kinase Inhibitors; D016159:Tumor Suppressor Protein p53; D014050:Toluene; C121565:pifithrin; D048670:MAP Kinase Kinase 4; D006918:Hydroxyurea