title: [Diagnostic Value of Neutrophil CD64 for Bacterial Infection in Patients with Hematologic Malignancies after Chemotherapy].
abstract: OBJECTIVE
  To investigate the value of CD64 mean fluorescence intensity of the peripheral blood neutrophils as a diagnostic marker of bacterial infection in patients with hematologic malignancies after chemotherapy.
  
  
  METHODS
  The neutrophil CD64 mean fluorescence intensity of all patients was detected by flow cytometry, and compared with procalcitonin (PCT) and C reactive protein (CRP) detected in part of patients; the relationship between nCD64 and bacterial infection were analyzed through continuous dynamic monitoring nCD64 mean fluorescence intensity in part of patients.
  
  
  RESULTS
  The expression of nCD64 was not affected by neutrophils counts (P>0.01); the nCD64 mean fluorescence intensity, PCT and CRP levels in infection group and dynamic monitoring group were significantly higher than those in non-infected group (P<0.01); the sensitivity and specificity of nCD64 mean fluorescence intensity were much higher, as compared with PCT and CRP in diagnosis of bacterial infection.
  
  
  CONCLUSIONS
  nCD64 mean fluorescence intensity can be used as an effective diagnostic marker for bacterial infection in patients with hematologic malignancies after chemotherapy, and may be used to forecast bacterial infection to a certain extent.
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Jin-Shu
authors.initials: JS
authors.lastname: Shi
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail: jeniferjian@gmail.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents; D001424:Bacterial Infections; D002097:C-Reactive Protein; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D005434:Flow Cytometry; D019337:Hematologic Neoplasms; D006801:Humans; D009504:Neutrophils; D011498:Protein Precursors; D017452:Receptors, IgG
chemical_list: D000970:Antineoplastic Agents; C000606589:CALCA protein, human; D011498:Protein Precursors; D017452:Receptors, IgG; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide