title: A Family History of Lethal Prostate Cancer and Risk of Aggressive Prostate Cancer in Patients Undergoing Radical Prostatectomy.
abstract: We investigated whether a family history of lethal prostate cancer (PCa) was associated with high-risk disease or biochemical recurrence in patients undergoing radical prostatectomy. A cohort of radical prostatectomy patients was stratified into men with no family history of PCa (NFH); a first-degree relative with PCa (FH); and those with a first-degree relative who had died of PCa (FHD). Demographic, operative and pathologic outcomes were analyzed. Freedom from biochemical recurrence was examined using Kaplan-Meier log rank. A multivariate Cox logistic regression analysis was also performed. We analyzed 471 men who underwent radical prostatectomy at our institution with known family history. The three groups had: 355 patients (75%) in NFH; 97 patients (21%) in FH; and 19 patients (4%) in FHD. The prevalence of a Gleason score ≥8, higher pathologic T stage, and biochemical recurrence (BCR) rates did not significantly differ between groups. On Kaplan-Meier analysis there were no differences in short-term BCR rates (p = 0.212). In this cohort of patients undergoing radical prostatectomy, those with first-degree relatives who died of PCa did not have an increased likelihood of high-risk or aggressive PCa or shorter-term risk of BCR than those who did not.
authors.affiliation: Department of Urology, UC San Diego Health System, San Diego, CA, United States.
authors.forename: Omer A
authors.initials: OA
authors.lastname: Raheem
authors.affiliation: Department of Urology, UC San Diego Health System, San Diego, CA, United States.
authors.forename: Seth A
authors.initials: SA
authors.lastname: Cohen
authors.affiliation: Department of Urology, UC San Diego Health System, San Diego, CA, United States.
authors.forename: J Kellogg
authors.initials: JK
authors.lastname: Parsons
authors.affiliation: Department of Urology, UC San Diego Health System, San Diego, CA, United States.
authors.forename: Kerrin L
authors.initials: KL
authors.lastname: Palazzi
authors.affiliation: Department of Urology, UC San Diego Health System, San Diego, CA, United States.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kane
mesh_terms: D000367:Age Factors; D000368:Aged; D015331:Cohort Studies; D003710:Demography; D018572:Disease-Free Survival; D005192:Family Health; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen