title: Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment.
abstract: Recently it was discovered that a transient activation of transcription factor NF-κB can give cells properties essential for invasiveness and cancer initiating potential. In contrast, most oncogenes to date were characterized on the basis of mutations or by their constitutive overexpression. Study of NF-κB actually leads to a far more dynamic perspective on cancer: tumors caused by diverse oncogenes apparently evolve into cancer after loss of feedback regulation for NF-κB. This event alters the cellular phenotype and the expression of hormonal mediators, modifying signals between diverse cell types in a tissue. The result is a disruption of stem cell hierarchy in the tissue, and pervasive changes in the microenvironment and immune response to the malignant cells.
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece. Electronic address: v_spiros@hotmail.com.
authors.forename: Spiros A
authors.initials: SA
authors.lastname: Vlahopoulos
authors.affiliation: Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, United States.
authors.forename: Osman
authors.initials: O
authors.lastname: Cen
authors.affiliation: Bernard J. Dunn School of Pharmacy, Shenandoah University, United States.
authors.forename: Nina
authors.initials: N
authors.lastname: Hengen
authors.affiliation: Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, United States.
authors.forename: James
authors.initials: J
authors.lastname: Agan
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Moschovi
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.
authors.forename: Elena
authors.initials: E
authors.lastname: Critselis
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Adamaki
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.
authors.forename: Flora
authors.initials: F
authors.lastname: Bacopoulou
authors.affiliation: Mayo Clinic Comprehensive Cancer Center, Department of Cancer Biology, United States.
authors.forename: John A
authors.initials: JA
authors.lastname: Copland
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, University of Texas Medical Branch at Galveston, United States.
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
authors.affiliation: Department of Pharmacology, University of California, San Diego, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
authors.affiliation: First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens, Greece.
authors.forename: George P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D059016:Tumor Microenvironment / Q000502:physiology*
chemical_list: D016328:NF-kappa B
keywords: Cancer; Homeostasis; Immunity; Inflammation; Nuclear Factor kappa B