title: Reduction in delta activity predicted improved negative affect in Major Depressive Disorder.
abstract: While prior research has demonstrated a paradoxical antidepressant effect of slow-wave disruption (SWD), the specific dimensions of depression affected is still unclear. The current study aimed to extend this research by utilizing a dimensional approach in examining the antidepressant effects of SWD. Of particular interest is the affective dimension, as negative affect in depression is arguably the most salient characteristic of depression. This sample included 16 individuals with depression (10 female) recruited from the community. Participants slept in the lab for three nights (adaptation, baseline night, and SWD) with polysomnography, and completed measures of negative affect and depression severity the following morning. Results show that reduction in delta power was linearly associated with improved negative affect. Comparison of individual change scores revealed that half of the individuals showed improved negative affect, which is comparable to the reported 40-60% antidepressant response rate to sleep deprivation. Results suggest that vulnerability in the sleep homeostatic system may be a contributing individual differences factor in response to slow-wave disruption in depression.
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States. Electronic address: pcheng1@hfhs.org.
authors.forename: Philip
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Goldschmied
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Melynda
authors.initials: M
authors.lastname: Casement
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Hyang Sook
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Hoffmann
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Roseanne
authors.initials: R
authors.lastname: Armitage
authors.affiliation: Department of Psychiatry University of Michigan, Ann Arbor, Ann Arbor MI 48105, United States.
authors.forename: Patricia
authors.initials: P
authors.lastname: Deldin
mesh_terms: D000293:Adolescent; D000328:Adult; D003700:Delta Rhythm / Q000502:physiology*; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography / Q000379:methods*; D011237:Predictive Value of Tests; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D055815:Young Adult
keywords: Affect; Depression; Slow-wave disruption; Slow-wave sleep