title: Association between IL-1β, IL-8, and IL-10 polymorphisms and risk of acute pancreatitis.
abstract: We assessed the possible correlation between genetic polymorphisms in interleukin (IL)-1β, IL-8, and IL-10 and risk of acute pancreatitis. Polymorphisms of IL-1β+3954C/T (rs1143634), IL-1β-511C/T (rs16944), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1800871) were assessed by polymerase chain reaction-restriction fragment length polymorphism. Patients with acute pancreatitis were more likely to have a family history of acute pancreatitis and a habit of tobacco smoking and alcohol drinking. Conditional logistic regression analyses showed that subjects carrying IL-10 -1082A/G and IL-8 -251 AA genotype with the A allele were significantly associated with an increased risk of acute pancreatitis, with adjusted odds ratio (95% confidence interval) of 1.82 (1.01-3.31) and 1.39 (1.02-1.90), respectively. However, we did not observe that IL-1β +3954C/T, IL-1β -511C/T, IL-10 -1082A/G, and IL-10 -819C/T polymorphisms were associated with the risk of acute pancreatitis. We found that the IL-8 -251T/A polymorphism is associated with an increased risk of acute pancreatitis, and no significant association between IL-1βand IL-10 gene polymorphisms and risk of acute pancreatitis was detected.
authors.affiliation: Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China lidapeng667@126.com.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D016209:Interleukin-8 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D053583:Interleukin-1beta; D016209:Interleukin-8; D016753:Interleukin-10