title: Stereotactic Body Radiation Therapy for Liver Lesions. A Single-institution Experience.
abstract: OBJECTIVE
  To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies.
  
  
  METHODS
  From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT.
  
  
  RESULTS
  The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events.
  
  
  CONCLUSIONS
  SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy donatella.caivano@gmail.com.
authors.forename: Donatella
authors.initials: D
authors.lastname: Caivano
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bracci
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Russo
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Adelaide
authors.initials: A
authors.lastname: Montalto
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Armosini
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Vitaliana
authors.initials: V
authors.lastname: De Sanctis
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Valeriani
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy; IRCCS Neuromed, Pozzilli (IS), Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Minniti
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Riccardo Maurizi
authors.initials: RM
authors.lastname: Enrici
authors.affiliation: Department of Radiation Oncology, Faculty of Medicina e Psicologia, Sant'Andrea Hospital, University of Rome Sapienza, Rome, Italy.
authors.forename: Mattia Falchetto
authors.initials: MF
authors.lastname: Osti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D006801:Humans; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D016634:Radiosurgery / Q000009:adverse effects*; D012189:Retrospective Studies
keywords: liver metastases; primary liver tumor; stereotactic body radiation therapy