title: Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study.
abstract: OBJECTIVE
  Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP × dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies.
  
  
  METHODS
  SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad BeadChip, total fat intake derived from a 3-day weighted food record, and SNP × total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects.
  
  
  RESULTS
  The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10(-5), including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4.
  
  
  CONCLUSIONS
  This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD.
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, Québec, Qué., Canada.
authors.forename: Iwona
authors.initials: I
authors.lastname: Rudkowska
authors.forename: Louis
authors.initials: L
authors.lastname: Pérusse
authors.forename: Claire
authors.initials: C
authors.lastname: Bellis
authors.forename: John
authors.initials: J
authors.lastname: Blangero
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Després
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
mesh_terms: D000328:Adult; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011792:Quebec
chemical_list: D004041:Dietary Fats; D008077:Lipoproteins, LDL