title: Regenerative Approach to Scleroderma with Fat Grafting.
abstract: Grafted fat has many qualities of ideal filler; it is autologous, easily available, and naturally integrated into the host tissues. From a lipoaspirate, the adipose-tissue-derived stromal vascular fraction can be isolated, which is an excellent source of stem/stromal cells, endothelial progenitors, and immune cells. Fat grafting is being increasingly applied in autoimmune diseases, and this article focuses on systemic sclerosis, a rare autoimmune disease characterized by skin fibrosis and microvascular damage. The authors' approach of using fat graft in the face and adipose-tissue-derived stromal vascular fraction for hands is presented as innovative and promising therapy for patients with systemic sclerosis.
authors.affiliation: Plastic Surgery Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France; Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France. Electronic address: secretariat.magalon@gmail.com.
authors.forename: Guy
authors.initials: G
authors.lastname: Magalon
authors.affiliation: Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13010 Marseilles, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Daumas
authors.affiliation: Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13010 Marseilles, France.
authors.forename: Nolwenn
authors.initials: N
authors.lastname: Sautereau
authors.affiliation: Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Magalon
authors.affiliation: Culture and Cell Therapy Laboratory, INSERM CBT-1409, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13005 Marseilles, France; Vascular Research Center Marseilles, INSERM UMRS-1076, Aix-Marseilles University, 13005 Marseilles, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Sabatier
authors.affiliation: Internal Medicine Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, 13010 Marseilles, France; Vascular Research Center Marseilles, INSERM UMRS-1076, Aix-Marseilles University, 13005 Marseilles, France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Granel
mesh_terms: D017667:Adipocytes / Q000637:transplantation; D000273:Adipose Tissue / Q000502:physiology / Q000637:transplantation*; D005145:Face / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005355:Fibrosis; D006225:Hand / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D012038:Regeneration; D012595:Scleroderma, Systemic / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D012867:Skin / Q000473:pathology / Q000503:physiopathology; D033581:Stem Cell Transplantation; D020858:Tissue and Organ Harvesting; D014182:Transplantation, Autologous
keywords: Adipose tissue; Autologous fat graft; Cell therapy; Fat grafting; Microfat injection; Stromal vascular fraction; Systemic sclerosis