title: Therapeutic efficacy of paclitaxel and carboplatin via arterial or venous perfusion in rabbits with VX-2 tongue cancer.
abstract: OBJECTIVE
  This study aimed to investigate the therapeutic efficacy of paclitaxel in combination with carboplatin in different ways in rabbits with VX-2 tongue cancer.
  
  
  METHODS
  Rabbit VX-2 tongue cancer model was established and animals were then divided into 6 groups, in which animals received perfusion with paclitaxel liposome and carboplatin via the lingual artery, with free paclitaxel and carboplatin via the lingual artery, with 5% glucose via the lingual artery, with paclitaxel liposome and carboplatin via ear vein, with free paclitaxel and carboplatin via the ear vein and with 5% glucose via the ear vein independently. When the maximum diameter of cervical lymph nodes was larger than 5 mm, chemotherapy was initiated. Seven days later, flow cytometry and immunohistochemistry were performed to detect the apoptosis of VX-2 cells and P53 expression in the primary cancer and metastatic lymph nodes.
  
  
  RESULTS
  Targeted arterial perfusion with paclitaxel liposome in combination with carboplatin was more effective to induce the apoptosis of cancer cells in the primary cancer and metastatic lymph nodes and inhibit their proliferation.
  
  
  CONCLUSIONS
  Targeted arterial perfusion with paclitaxel liposome in combination with carboplatin is effective to reduce tumor size, attenuate the surgery induced injury and improve the post-operative quality of life of oral cancer patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Ni-Ni
authors.initials: NN
authors.lastname: Zhang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Li-Gang
authors.initials: LG
authors.lastname: Zhang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Ze-Nian
authors.initials: ZN
authors.lastname: Liu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.affiliation: Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Zunyi Medical College Zunyi 563003, Guizhou, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Hu
keywords: Paclitaxel; paclitaxel liposome; targeted arterial perfusion