title: Comparative Study of Carcinoembryonic Antigen Tumor Marker in Stomach and Colon Cancer Patients in Khyber Pakhtunkhwa.
abstract: BACKGROUND
  Due to the increase in morbidity and mortality rate, cancer has become an alarming threat to the human population worldwide. Since cancer is a progressive disorder, timely diagnosis would be helpful to prevent/stop cancer from progressing to severe stage. In Khyber Pakhtunkhwa, Pakistan, most of the time, tumors are diagnosed with endoscopy and biopsy; therefore rare studies exist regarding the diagnosis of gastrointestinal (GIT) carcinomas based on tumor markers, especially CEA.
  
  
  OBJECTIVE
  This study made a comparative analysis of CEA in admitted hospitalized stomach and colon cancer patients diagnosed as GIT with biopsy.
  
  
  METHODS
  In this study, a total of 66 cases were included. The level of CEA was determined in the blood of these patients using ELISA technique.
  
  
  RESULTS
  Out of 66 patients, the level of CEA was high in 59.1% of the total, 60.7% in colon cancer patients and 57.9 % in stomach cancer patients. Moreover, the incidence of colorectal and stomach cancer was greater in males as compared to females. Patients were more of the age group of 40- 60 and the level of CEA was comparatively higher in patients (51.5%) with histology which was moderately differentiated, than patients with well differentiated and poorly differentiated tumor histology.
  
  
  CONCLUSIONS
  CEA level was high in more than 50% of the total patients. Moreover, CEA exhibited higher sensitivity for colon than stomach cancer.
authors.affiliation: Centre for Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan E-mail : vet_sajid@yahoo.com.
authors.forename: Bashir
authors.initials: B
authors.lastname: Ahmad
authors.forename: Bushra
authors.initials: B
authors.lastname: Gul
authors.forename: Sajid
authors.initials: S
authors.lastname: Ali
authors.forename: Shumaila
authors.initials: S
authors.lastname: Bashir
authors.forename: Nourin
authors.initials: N
authors.lastname: Mahmood
authors.forename: Jamshed
authors.initials: J
authors.lastname: Ahmad
authors.forename: Seema
authors.initials: S
authors.lastname: Nawaz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000378:metabolism*; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010154:Pakistan; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen