title: Phyllodes Tumor of the Breast With Malignant Melanoma Component: A Case Report.
abstract: Phyllodes tumors of the breast display a wide variation in histological appearance and are classified into benign, borderline, and malignant categories based on a combination of histological parameters. These tumors may include a malignant heterologous component that is believed to originate through a process of multidirectional differentiation from a cancer stem cell. In these cases, the tumor is classified as a malignant phyllodes tumor. Among the heterologous elements that have been described in malignant phyllodes tumors are rhabdomyosarcoma, chondrosarcoma, osteosarcoma, liposarcoma and angiosarcoma. We present the first case of a phyllodes tumor with a malignant melanoma component in the breast of a 71-year-old lady, discussing the clinical implications of this diagnosis.
authors.affiliation: Department of Histopathology, Royal Sussex County Hospital, Brighton and Sussex University Hospitals, Brighton, UK marco.vergine@bsuh.nhs.uk.
authors.forename: Marco
authors.initials: M
authors.lastname: Vergine
authors.affiliation: Department of Histopathology, Royal Sussex County Hospital, Brighton and Sussex University Hospitals, Brighton, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Guy
authors.affiliation: Department of Histopathology, Royal Sussex County Hospital, Brighton and Sussex University Hospitals, Brighton, UK.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Taylor
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D018193:Neoplasms, Complex and Mixed / Q000473:pathology*; D003557:Phyllodes Tumor / Q000473:pathology*
keywords: breast; cancer stem cell; heterologous elements; malignant melanoma; multidirectional divergent differentiation; phyllodes tumor