title: Calcium Hydride Catalyzed Highly 1,2-Selective Pyridine Hydrosilylation.
abstract: Reaction of the calcium hydride complex (DIPPnacnac-CaH⋅THF)2 with pyridine is much faster and selective than that of the corresponding magnesium hydride complex (DIPPnacnac = [(2,6-iPr2 C6 H3 )NC(Me)]2 CH). With a range of pyridine, picoline and quinoline substrates, exclusive transfer of the hydride ligand to the 2-position is observed and also at higher temperatures no 1,2→1,4 isomerization is found. The heteroleptic product DIPPnacnac-Ca(1,2-dihydropyridide)⋅(pyridine) shows fast ligand exchange into homoleptic calcium complexes and therefore could not be isolated. Calcium hydride reduction of isoquinoline gave well-defined homoleptic products which could be characterized by X-ray diffraction: Ca(1,2-dihydroisoquinolide)2 ⋅(isoquinoline)4 and Ca3 (1,2-dihydroisoquinolide)6 ⋅(isoquinoline)6 . The striking selectivity difference in the dearomatization of pyridines by Mg or Ca complexes could be explained by DFT theory and was utilized in catalysis. Whereas hydroboration of pyridine with pinacol borane with a calcium hydride catalyst gave only minor conversion, the hydrosilylation of pyridine and quinolines with PhSiH3 yields exclusively 1,2-dihydropyridine and 1,2-dihydroquinoline silanes with 80-90 % conversion. Similar results can be achieved with the catalyst Ca[N(SiMe3 )2 ]2 ⋅(THF)2 . These calcium complexes represent the first catalysts for the 1,2-selective hydrosilylation of pyridines.
authors.affiliation: Stratingh Institute for Chemistry, Nijenborgh 4, 9747AG Groningen (The Netherlands).
authors.forename: Julia
authors.initials: J
authors.lastname: Intemann
authors.affiliation: Friedrich-Alexander University Erlangen-Nürnberg, Inorganic and Organometallic Chemistry, Egerlandstraße 1, 91058 Erlangen (Germany).
authors.forename: Heiko
authors.initials: H
authors.lastname: Bauer
authors.affiliation: Friedrich-Alexander University Erlangen-Nürnberg, Inorganic and Organometallic Chemistry, Egerlandstraße 1, 91058 Erlangen (Germany).
authors.forename: Jürgen
authors.initials: J
authors.lastname: Pahl
authors.affiliation: Université de Toulouse et CNRS INSA, UPS, CNRS, UMR 5215, LPCNO, 135 avenue de Rangueil, 31077 Toulouse (France).
authors.forename: Laurent
authors.initials: L
authors.lastname: Maron
authors.affiliation: Friedrich-Alexander University Erlangen-Nürnberg, Inorganic and Organometallic Chemistry, Egerlandstraße 1, 91058 Erlangen (Germany).
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Harder
keywords: calcium; catalysis; hydride; hydrosilylation; reduction