title: Increasing Complexity of Vaccine Development.
abstract: Vaccines already developed have been enormously successful. However, the development of future vaccines requires solution of a number of immunologic problems, including pathogen variability, short effector memory, evoking functional responses, and identification of antigens that generate protective responses. In addition, different populations may respond differently to the same vaccine because of genetic, age, or environmental factors.
authors.affiliation: University of Pennsylvania, Doylestown.
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Plotkin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control; D000486:Allergy and Immunology / Q000639:trends*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D014612:Vaccines / Q000276:immunology*; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control
chemical_list: D014612:Vaccines
keywords: HIV; correlates of protection; cytomegalovirus; dengue; immune memory; influenza; pertussis; respiratory syncytial virus; rotavirus