title: Association of COMT G675A and MTHFR C677T polymorphisms with hypertensive disorders of pregnancy in Mexican mestizo population.
abstract: OBJECTIVE
  To investigate the relationship between COMT G675A and MTHFR C677T polymorphisms and hypertension disorders of pregnancy (HDP) in a Mexican mestizo population.
  
  
  METHODS
  This case-control study involved 194 HDP and 194 normoevolutive pregnant women. The polymorphisms were genotyped by real time PCR.
  
  
  RESULTS
  Our results showed that the COMT AA genotype increases the risk to HDP (OR: 2.67; 95% CI 1.33-5.35), preeclampsia (OR: 2.69; 95% CI 1.00-7.22) and gestational hypertension (OR: 3.87; 95% CI 1.25-12.0). Furthermore, the double mutant genotype (COMTAA/MTHFRTT) potency the risk to HDP more than two times (OR: 5.21; 95% CI 1.12-24.3, p=0.019).
  
  
  CONCLUSIONS
  Our work provides evidence that COMT 675AA genotype is a risk factor for HDP and that this risk is increased by the presence of MTHFR 677TT genotype in a Mexican mestizo population.
authors.affiliation: Hospital General de Durango, Secretaría de Salud, Zip Code 34000, Durango, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Vazquez-Alaniz
authors.affiliation: Hospital General de Durango, Secretaría de Salud, Zip Code 34000, Durango, Mexico.
authors.forename: Mario I
authors.initials: MI
authors.lastname: Lumbreras-Márquez
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico.
authors.forename: Ada A
authors.initials: AA
authors.lastname: Sandoval-Carrillo
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico.
authors.forename: Marisela
authors.initials: M
authors.lastname: Aguilar-Durán
authors.affiliation: Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico.
authors.forename: Edna M
authors.initials: EM
authors.lastname: Méndez-Hernández
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Barraza-Salas
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico.
authors.forename: Francisco X
authors.initials: FX
authors.lastname: Castellanos-Juárez
authors.affiliation: Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Zip Code 34000, Durango, Mexico. Electronic address: jsalas_pacheco@hotmail.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Salas-Pacheco
keywords: COMT; Hypertensive disorders of pregnancy; MTHFR; Polymorphisms