title: Inflammatory bowel diseases in anti-neutrophil cytoplasmic antibody-associated vasculitides: 11 retrospective cases from the French Vasculitis Study Group.
abstract: OBJECTIVE
  Coexistence of ANCA-associated vasculitis (AAV) and IBD is a rare condition that is rarely described in the literature. The aim of the study was to describe the main characteristics of patients presenting with both IBD and AAV.
  
  
  METHODS
  A retrospective study of AAV patients in the French Vasculitis Study Group cohort who also had a diagnosis of IBD was conducted. We reviewed the medical records and outcomes of these patients.
  
  
  RESULTS
  We identified 11 patients with AAV and IBD. Four patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss) also had ulcerative colitis and seven patients with granulomatosis with polyangiitis (GPA) had Crohn's disease. No Crohn's disease was observed in eosinophilic GPA and no ulcerative colitis in GPA. IBD started before AAV manifestations in six cases, simultaneously in two cases and after AAV manifestations in three cases.
  
  
  CONCLUSIONS
  Coexistence of IBD and AAV is a rare condition. The therapeutic management of these patients includes corticosteroids in all cases and immunosuppressive drugs in some patients. Coexistence of IBD and AAV might be explained by common underlying inflammatory responses and cytokine profiles polarized towards either Th1 or Th2. Finally, in the presence of digestive manifestations in the context of AAV, the hypothesis of IBD should be assessed.
authors.affiliation: Service de Médecine Interne, Université Montpellier 1, Maladies Multi-organiques, centre de compétence des maladies systémiques et auto-immunes rares de l'adulte, Hôpital Saint-Eloi, CHRU de Montpellier, Montpellier.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Humbert
authors.affiliation: Service de Médecine Interne, Université Montpellier 1, Maladies Multi-organiques, centre de compétence des maladies systémiques et auto-immunes rares de l'adulte, Hôpital Saint-Eloi, CHRU de Montpellier, Montpellier, p-guilpain@chu-montpellier.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guilpain
authors.affiliation: Faculté de Médecine, Université Paris Descartes, Pôle de Médecine Interne et Centre National de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hôpital Cochin, APHP, Paris.
authors.forename: Xavier
authors.initials: X
authors.lastname: Puéchal
authors.affiliation: Faculté de Médecine, Université Paris Descartes, Pôle de Médecine Interne et Centre National de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hôpital Cochin, APHP, Paris.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Terrier
authors.affiliation: Service de Médecine Interne, Université Montpellier 1, Maladies Multi-organiques, centre de compétence des maladies systémiques et auto-immunes rares de l'adulte, Hôpital Saint-Eloi, CHRU de Montpellier, Montpellier.
authors.forename: Sophie
authors.initials: S
authors.lastname: Rivière
authors.affiliation: Service de Médecine Interne, Hôpital Saint-Louis, Université Paris 7, APHP, Paris.
authors.forename: Alfred
authors.initials: A
authors.lastname: Mahr
authors.affiliation: Faculté de Médecine, Université Paris Descartes, Pôle de Médecine Interne et Centre National de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hôpital Cochin, APHP, Paris.
authors.forename: Christian
authors.initials: C
authors.lastname: Pagnoux
authors.affiliation: Service de médecine interne, hôpital Nord, Assistance publique-Hôpitaux de Marseille, Marseille.
authors.forename: Denis
authors.initials: D
authors.lastname: Bagnères
authors.affiliation: Service de Pneumologie, Centre de Référence des Maladies Orphelines Pulmonaires, Hôpital Louis Pradel, Université Lyon I, Hospices Civils de Lyon, Lyon and.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cordier
authors.affiliation: Service de Médecine Interne, Université Montpellier 1, Maladies Multi-organiques, centre de compétence des maladies systémiques et auto-immunes rares de l'adulte, Hôpital Saint-Eloi, CHRU de Montpellier, Montpellier.
authors.forename: Alain
authors.initials: A
authors.lastname: Le Quellec
authors.affiliation: Département d'Hépato-Gastroentérologie, Hôpital Saint-Eloi, Université Montpellier 1, CHRU de Montpellier, Montpellier, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Altwegg
authors.affiliation: Faculté de Médecine, Université Paris Descartes, Pôle de Médecine Interne et Centre National de Référence pour les Vascularites Nécrosantes et la Sclérodermie Systémique, Hôpital Cochin, APHP, Paris.
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D015897:Comorbidity; D003424:Crohn Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents
keywords: Crohn’s disease; anti-neutrophil cytoplasmic antibody; eosinophilic granulomatosis with polyangiitis (Churg–Strauss); granulomatosis with polyangiitis; ulcerative colitis