title: Human herpesvirus 6B reactivation and delirium are frequent and associated events after cord blood transplantation.
abstract: Human herpesvirus 6B (HHV-6B) frequently reactivates after cord blood transplantation (CBT). We previously reported an association between HHV-6B reactivation and delirium after hematopoietic cell transplantation. In this prospective study, 35 CBT recipients underwent twice-weekly plasma PCR testing for HHV-6 and thrice-weekly delirium assessment until day 84. There was a quantitative association between HHV-6B reactivation and delirium in univariable (odds ratio, 2.88; 95% confidence interval (CI), 0.97-8.59) and bivariable models. In addition, intensified prophylaxis with high-dose valacyclovir mitigated HHV-6B reactivation (adjusted hazard ratio, 0.39; 95% CI, 0.14-1.08). Larger trials are needed to explore the utility of HHV-6B prophylaxis after CBT.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.|Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Hill
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.|Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Boeckh
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: W M
authors.initials: WM
authors.lastname: Leisenring
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Xie
authors.affiliation: Pediatric Infectious Diseases, Seattle Children's Research Institute, Seattle, WA, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Adler
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: M-L
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Fann
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|Department of Pediatrics, University of Washington, Seattle, WA, USA.
authors.forename: C
authors.initials: C
authors.lastname: Delaney
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|Pediatric Infectious Diseases, Seattle Children's Research Institute, Seattle, WA, USA.|Department of Pediatrics, University of Washington, Seattle, WA, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Zerr
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D003693:Delirium / Q000209:etiology*; D015654:Herpesvirus 6, Human / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D055815:Young Adult