title: Developing a Successful HIV Vaccine.
abstract: Human immunodeficiency virus (HIV) genome integration indicates that persistent sterilizing immunity will be needed for a successful vaccine candidate. This suggests a need for broad antibodies targeting the Env protein. Immunogens targeting gp120 have been developed that block infection in monkeys and mimic the modest success of the RV144 clinical trial in that protection is short-lived following a decline in antibody-depending cell-mediated cytotoxicity-like antibodies. Attempts to induce antibody persistence have been complicated by a loss of efficacy, presumably by increasing the number of HIV-target cells. The key seems to be achieving an immune balance.
authors.affiliation: Institute of Human Virology, University of Maryland School of Medicine, Baltimore.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Gallo
mesh_terms: D016915:AIDS Vaccines; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D016679:Genome, Viral; D006678:HIV / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D015483:HIV Antibodies; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D054299:env Gene Products, Human Immunodeficiency Virus
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D054299:env Gene Products, Human Immunodeficiency Virus
keywords: AIDS; HIV; T cells; antibodies; vaccine