title: Maternal cardiac and obstetric performance in consecutive pregnancies in women with heart disease.
abstract: OBJECTIVE
  Second pregnancies are usually less complicated than first pregnancies, and have a better outcome in terms of fetal growth. We studied a group of women with heart disease to assess whether their second pregnancy was less complicated and resulted in a larger baby.
  
  
  METHODS
  Retrospective case control study.
  
  
  METHODS
  Tertiary referral academic obstetric unit.
  
  
  METHODS
  First and second pregnancies in 77 women with congenital and acquired heart disease and in 154 control women were identified.
  
  
  METHODS
  Data were collected from medical and obstetric records.
  
  
  METHODS
  Cardiac complications, obstetric complications, intra-partum events, birthweight and perinatal complications.
  
  
  RESULTS
  The rate of obstetric complication was greater in first pregnancies in both the heart disease and the control groups (38% versus 26%, cf. 20% versus 17%). In the heart disease group, the rate of cardiac complications was similar in first and second pregnancies (9% versus 6%). Overall, significantly more perinatal complications were seen in the heart disease group, with no significant difference between first and second pregnancies (36% versus 27%, cf. 14% versus 12%). Median birthweight was significantly higher in second pregnancies in the control group (3308 versus 3519 g P < 0.001), but not significantly different between pregnancies in the heart disease group (3014 versus 3133 g, P = 0.19).
  
  
  CONCLUSIONS
  This case control study demonstrates that women with mild to moderate heart disease have similar pregnancy outcomes in consecutive pregnancies. However, while the median birthweight was higher in the control second pregnancies, it was not increased in the women with heart disease.
  
  
  CONCLUSIONS
  A study of women with heart disease to assess whether their second pregnancy was less complicated.
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Gelson
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, London, UK.|Department of Maternal and Fetal Medicine, Institute for Women's Health, University College London, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Curry
authors.affiliation: Adult Congenital Heart Centre, The National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Gatzoulis
authors.affiliation: Adult Congenital Heart Centre, The National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Swan
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, London, UK.|Adult Congenital Heart Centre, The National Heart and Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Lupton
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Steer
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Johnson
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural / Q000706:statistics & numerical data; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D020073:Gravidity; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012720:Severity of Illness Index; D006113:United Kingdom / Q000453:epidemiology
keywords: Birth; heart disease; obstetric outcomes; parity