title: Correlation between promoter methylation in the GSTP1 gene and hepatocellular carcinoma development: a meta-analysis.
abstract: Epigenetic silencing of the GSTP1 gene by promoter methylation has been associated with increased risk and shortened survival in patients with hepatocellular carcinoma (HCC). We therefore conducted a meta-analysis to obtain a more precise estimate of this association. By searching the Cochrane Library, CBM, EMBASE, PubMed, and the Web of Science, we tabulated and analyzed parameters from each study. Results were summarized by meta-analyses using the version 12.0 STATA software. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were also calculated in this analysis. A total of 14 cohort studies (tumor samples = 607, adjacent samples = 356, benign samples = 182, normal samples = 133) were included for the following statistical analysis. Our meta-analysis results demonstrated that the frequency of GSTP1 methylation in cancer tissues was significantly higher than those in adjacent tissues, benign tissues, and normal tissues (all P < 0.05). Further subgroup analysis by country indicated that the frequency of aberrant GSTP1 promoter methylation was correlated to the development of HCC among all the included experimental subgroups (all P < 0.05). The results indicate a significant association between GSTP1 methylation and poor outcomes in HCC patients.
authors.affiliation: Department of Infectious Diseases, Liao Cheng People's Hospital, Liaocheng, China liqingfang614@126.com.
authors.forename: Q F
authors.initials: QF
authors.lastname: Li
authors.affiliation: Department of Infectious Diseases, Liao Cheng People's Hospital, Liaocheng, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Third Hospital of Liaocheng, Liaocheng, China.
authors.forename: A R
authors.initials: AR
authors.lastname: Gao
authors.affiliation: Department of Infectious Diseases, Liao Cheng People's Hospital, Liaocheng, China.
authors.forename: Q F
authors.initials: QF
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011401:Promoter Regions, Genetic; D016019:Survival Analysis
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi