title: Endovascular trophoblast and preeclampsia: A reassessment.
abstract: Since the earliest report on impaired spiral artery remodelling in preeclamptic human pregnancies, numerous studies have been devoted to possible mechanisms of impaired trophoblast invasion. A better knowledge of early uteroplacental blood flow has provided a physiological context for the processes of spiral artery invasion and associated remodelling, revealing a closely timed relationship between increasing flow and early steps in vascular remodelling. Concerning the impaired trophoblast invasion in preeclampsia, it has also to be considered that impaired invasion not only concerns invasion depth per se, but also the extension of this deep invasion from the central towards the more lateral spiral arteries of the placental bed. Since also in preeclampsia the very central spiral arteries may be normally invaded, the existence of such spatial gradient provides a further dimension to the problem. A practical consequence is that frequently used rodent models, which show invasion of two or three spiral arteries only, may be less useful for studying this particular aspect of the disease. Amongst non-human primates, baboons and rhesus monkeys are 'shallow invaders', and only in some of the great apes deep trophoblast invasion and associated spiral artery remodelling occurs. A better knowledge of the evolutionary history of deep invasion and its possible selective benefit might ultimately improve our understanding of failed deep invasion and impaired spiral artery remodelling in preeclampsia.
authors.affiliation: Department of Woman and Child, University Hospital Leuven, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Pijnenborg
authors.affiliation: Department of Woman and Child, University Hospital Leuven, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Vercruysse
authors.affiliation: Department of Woman and Child, University Hospital Leuven, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
authors.forename: Myriam
authors.initials: M
authors.lastname: Hanssens
authors.affiliation: Leuven Institute for Fertility and Embryology, Tiensevest 168, B-3000 Leuven, Belgium.
authors.forename: Ivo
authors.initials: I
authors.lastname: Brosens