title: OP004. A SNP associated with susceptibility to preeclampsia near the inhibin, beta B gene, is also associated with cardiovascular disease risk traits.
abstract: BACKGROUND
  It is well established that preeclampsia (PE) increases later life cardiovascular disease (CVD) risk. Consequently, PE has started to gain a role as an early screening criterion for CVD. PE and CVD share several risk factors, pathological features and metabolic abnormalities. These common antecedents have drawn attention to the likelihood of shared genetic susceptibility.
  
  
  OBJECTIVE
  Results from our previous PE GWAS identified a significant association with the rs7579169 SNP and maternal PE susceptibility (odds ratio 1.57). This SNP resides near the Inhibin, beta B (INHBB) gene on chromosome 2q14. Therefore, this study sought to interrogate this PE susceptibility SNP against several CVD risk traits in an effort to highlight additional empirical evidence of likely shared PE/CVD genetic mechanisms.
  
  
  METHODS
  The rs7579169 SNP was genotyped in a large independent Australian cohort rich in quantitative CVD risk traits; The Western Australian Pregnancy Cohort (Raine) Study. This cohort comprises of fasting blood samples from 1246 mothers and 1461 adolescents (14- and 17-year-old) and clinical parameters pertaining, but not limited, to anthropometric measures of adiposity and lipid-related measures. Genetic association analyses of rs7579169 against the Raine CVD-related risk traits were performed using the software package R. All statistical analyses assumed an additive model of gene action.
  
  
  RESULTS
  Significant associations (p<0.05) for rs7579169 with CVD-related risk traits were detected, both for the mothers and the adolescents. Specifically, the minor rs7579169-T allele (MAF 0.400) was found to be significantly associated with elevated levels of triglycerides, total and LDL cholesterol, a greater average waist:hip circumference ratio and a greater average hip circumference.
  
  
  CONCLUSIONS
  We have previously identified rs7579169 located near the INHBB gene on chromosome 2q14 to significantly associate with maternal PE susceptibility. We have now demonstrated that this SNP is also significantly associated with several CVD-related risk traits in an independent Caucasian population. We hereby present additional empirical evidence of possible shared genetic risk factors underlying both PE and CVD related traits.
authors.forename: Mari
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authors.lastname: Løset
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Johnson
authors.forename: Phillip E
authors.initials: PE
authors.lastname: Melton
authors.forename: Wei
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authors.lastname: Ang
authors.forename: Julie
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authors.lastname: Marsh
authors.forename: Rae-Chi
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authors.lastname: Huang
authors.forename: Trevor
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authors.lastname: Mori
authors.forename: Lawrence
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authors.lastname: Beilin
authors.forename: Craig
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authors.lastname: Pennell
authors.forename: Linda T
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authors.lastname: Roten
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Iversen
authors.forename: Rigmor
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authors.lastname: Austgulen
authors.forename: Christine E
authors.initials: CE
authors.lastname: East
authors.forename: John
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authors.lastname: Blangero
authors.forename: Shaun P
authors.initials: SP
authors.lastname: Brennecke
authors.forename: Eric K
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authors.lastname: Moses