title: Total Synthesis of Shishijimicin A.
abstract: The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.
authors.affiliation: Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.affiliation: Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
authors.forename: Zhaoyong
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
authors.forename: Ruofan
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
authors.forename: James R
authors.initials: JR
authors.lastname: Woods
authors.affiliation: Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
authors.forename: Te-ik
authors.initials: TI
authors.lastname: Sohn
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D004187:Disaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D053281:Enediynes / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D002243:Carbolines; D004187:Disaccharides; D053281:Enediynes; C472755:Shishijimicin A; D013438:Sulfhydryl Compounds; C005732:thioacetic acid