title: Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients.
abstract: Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported. The aim of the study was to investigate the relationship between the components of MetS with the SUA levels as also between SUA and apolipoproteins A1 and B (apoA1 and apoB) ratio in hypertensive patients. A total of 2577 consecutive hypertensive patients (1193 male and 1384 female) aged 57.5±13.3 years, were enrolled in our research. Samples were taken to measure SUA, glucose, triglycerides, high density lipoprotein (HDL-C), components of the MetS and apoA1 and apoB. The study population was divided into two groups: group A: SUA levels above normal range (men ⩾7 mg dl(-1), women ⩾6 mg dl(-1)) and group B: SUA levels within normal range. In the overall study population, SUA levels showed a statistically significant correlation with waist circumference (WC; r=0.293, P<0.000), triglycerides (r=0.197, P<0.000), glucose (r=0.085, P<0.000), apoB/apoA1 (r=0.136, P<0.000) and HDL-C (r=-0.235, P<0,001). In newly diagnosed untreated hypertensive patients there was also a statistically significant correlation of SUA levels with WC (r=0.331, P<0.001), triglycerides (r=0.228, P<0.001) apoB/apoA1 ratio (r=0.202, P<0.001) and HDL-C (r=-0.278, P<0.001). In hyperurecemic hypertensives there was a statistically significant correlation between SUA levels with WC (r=0.168, P=0.007), apoB/apoA1 ratio (r=0.256, P=0.003) and HDL-C (r=-0.202, P<0.001). SUA levels correlate significantly with all the components of MetS, as well as with the risk factor apoB/apoA1 ratio, in hypertensive patients.
authors.affiliation: Department of Cardiology, Sismanoglio General Hospital, Athens, Greece.
authors.forename: M V
authors.initials: MV
authors.lastname: Papavasileiou
authors.affiliation: Department of Cardiology, Sismanoglio General Hospital, Athens, Greece.
authors.forename: A G
authors.initials: AG
authors.lastname: Karamanou
authors.affiliation: Department of Cardiology, Agioi Anargyroi General Hospital, Athens, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Kalogeropoulos
authors.affiliation: Department of Cardiology, Sismanoglio General Hospital, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Moustakas
authors.affiliation: Department of Cardiology, Sismanoglio General Hospital, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Patsianis
authors.affiliation: Department of Cardiology, Mediton Cardiology Center, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Pittaras
mesh_terms: D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood; D053299:Apolipoprotein B-100 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D033461:Hyperuricemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: C505693:APOA1 protein, human; C569471:APOB protein, human; D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D014527:Uric Acid