title: ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE.
abstract: OBJECTIVE
  The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice.
  
  
  METHODS
  We measured free T4, thyroid-stimulating hormone (TSH) and Tg serum levels and studied thyroid morphology in 14 sortilin-deficient (Sort1)(-/-)and 12 wildtype (WT) mice.
  
  
  RESULTS
  Serum free T4 levels did not differ between Sort1(-/-)and WT females but were significantly lower in Sort1(-/-)males compared with WT (P = .0424). Neither serum TSH nor Tg levels differed between Sort1(-/-)and WT mice, regardless of sex. On the same line, no thyroid histology differences were observed.
  
  
  CONCLUSIONS
  Our findings seem to exclude a role of sortilin in thyroid hormone secretion, although it is possible that the absence of sortilin may result in a thyroid phenotype if combined with other molecular defects of thyroid hormone synthesis and secretion or under iodine deficiency.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Lisi
authors.forename: Peder
authors.initials: P
authors.lastname: Madsen
authors.forename: Roberta
authors.initials: R
authors.lastname: Botta
authors.forename: Claus Munck
authors.initials: CM
authors.lastname: Petersen
authors.forename: Anders
authors.initials: A
authors.lastname: Nykjær
authors.forename: Francesco
authors.initials: F
authors.lastname: Latrofa
authors.forename: Paolo
authors.initials: P
authors.lastname: Vitti
authors.forename: Michele
authors.initials: M
authors.lastname: Marinò
mesh_terms: D033942:Adaptor Proteins, Vesicular Transport / Q000172:deficiency* / Q000502:physiology*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010641:Phenotype; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D000099183:Sortilin
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D013954:Thyroglobulin; D013972:Thyrotropin; D013974:Thyroxine; D000099183:Sortilin