title: Double dispersant-assisted ionic liquid dispersive liquid-liquid microextraction coupled with capillary electrophoresis for the determination of benzophenone-type ultraviolet filters in sunscreen cosmetic product.
abstract: In this work, double dispersant-assisted ionic liquid dispersive liquid-liquid microextraction coupled with micellar electrokinetic chromatography was developed to determine four UV filters (benzophenone, 4-hydroxybenzophenone, 2,4-dihydroxybenzophenone, and 2-hydroxy-4-methoxybenzophenone). 1-Hexyl-3-methylimidazolium hexafluorophosphate was used as the extraction solvent. The main novelty of the present work was that acetonitrile-Triton X-114 was used as double disperser solvent. Parameters affected the extraction efficiency were investigated and optimized. Under the optimum conditions, enrichment factors were in the range of 25.3-40.5. The limits of detection and quantitation, calculated at a S/N of three and ten, were 3.9-6.7 ng/mL and 13.0-22.3 ng/mL. The linearity of the method was in the range of 0.02-2 μg/mL for 2, 4-dihydroxybenzophenone and 4-hydroxybenzophenone, 0.01-2 μg/mL for benzophenone and 2-hydroxy-4-methoxybenzophenone, with correlation coefficient (R(2)) of 0.9984-0.9991. The proposed method was successfully applied to the determination of four benzophenone-type UV filters in six kinds of sunscreen cosmetic products, with yielded relative recoveries ranging from 80.2 to 117.7%.
authors.affiliation: College of Chemistry, Jilin University, Changchun, P. R., China.
authors.forename: Teng
authors.initials: T
authors.lastname: Ma
authors.affiliation: College of Chemistry, Jilin University, Changchun, P. R., China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Jilin Entry and Exit Inspection and Quarantine Bureau of China, Changchun, P. R., China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Niu
authors.affiliation: College of Chemistry, Jilin University, Changchun, P. R., China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun, P. R., China.
authors.forename: Weihong
authors.initials: W
authors.lastname: Zhou
mesh_terms: D001577:Benzophenones / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D002498:Centrifugation; D003358:Cosmetics / Q000032:analysis*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry; D057230:Limit of Detection; D016014:Linear Models; D059627:Liquid Phase Microextraction / Q000379:methods*; D015203:Reproducibility of Results; D013473:Sunscreening Agents / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D001577:Benzophenones; D003358:Cosmetics; D007093:Imidazoles; D052578:Ionic Liquids; D013473:Sunscreening Agents; D013501:Surface-Active Agents; C047723:benzophenone
keywords: Benzophenone-type ultraviolet filters; Double dispersant-assisted extraction; Ionic liquid liquid-liquid microextraction; Micellar electrokinetic chromatography; Sunscreen cosmetic product