title: Clinical and Radiographic Evaluation of Immediate Loaded Dental Implants With Local Application of Melatonin: A Preliminary Randomized Controlled Clinical Trial.
abstract: Immediate loading of dental implants in situations where low bone density exist, such as the posterior maxillary region, became possible recently after the introduction of biomimetic agents. This 1-year preliminary clinical trial was carried out to clinically and radiographically evaluate immediate-loaded 1-piece implants with local application of melatonin in the osteotomy site as a biomimetic material. 14 patients with missing maxillary premolars were randomized to receive 14 implants of 1-piece type that were subjected to immediate loading after 2 weeks of initial placement. Group I included 7 implants with acid-etched surface while group II included 7 implants with acid-etched surface combined with local application of melatonin gel at the osteotomy site. Patients were recalled for follow up at 1, 3, 6, and 12 months after loading. All implants were considered successful after 12 months of follow-up. Significant difference (P < 0.05) was found between both groups at 1 month of implant loading when considering the implant stability. At 1 and 3 months there were significant differences in the marginal bone level between the 2 groups. These results suggest that the local application of melatonin at the osteotomy site is associated with good stability and minimal bone resorption. However, more studies for longer follow-up periods are required to confirm the effect of melatonin hormone on osseointegration of dental implants.
authors.affiliation: 1   Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
authors.forename: Mona Y
authors.initials: MY
authors.lastname: El-Gammal
authors.affiliation: 1   Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.|2   OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven and Department of Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: Salem
authors.affiliation: 3   Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Anees
authors.affiliation: 1   Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Tawfik
mesh_terms: D016301:Alveolar Bone Loss; D000975:Antioxidants / Q000008:administration & dosage; D003442:Crowns; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019250:Dental Implants, Single-Tooth; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D019232:Dental Restoration Failure; D005500:Follow-Up Studies; D006801:Humans; D008550:Melatonin / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015921:Dental Implants; D008550:Melatonin
keywords: acid-etched; immediate loading; implant; melatonin; one-piece