title: Antitumor activity of a rhenium (I)-diselenoether complex in experimental models of human breast cancer.
abstract: Rhenium (I)-diselenother (Re-diselenoether) is a water soluble metal-based compound, combining one atom of rhenium and two atoms of selenium. This compound has been reported to exhibit marked activities against several solid tumor cell lines. We now disclose an improved synthesis of this complex. The Re-diselenoether showed a potent inhibitory effect on MDA-MB231 cell division in vitro, which lasted when the complex was no longer present in the culture. Re-diselenoether induced a remarkable reduction of the volume of the primitive breast tumors and of the pulmonary metastases without clinical signs of toxicity, in mice-bearing a MDA-MB231 Luc+ tumor, orthotopically transplanted, after a daily oral administration at the dose of 10 mg/kg/d. Interestingly, an antagonism was observed when cisplatin was administered as a single i.p. injection 1 week after the end of the Re-diselenoether administration. In an effort to gain insight of the mechanisms of action of Re-diselenoether complex, interaction with 9-methylguanine as a nucleic acid base model was studied. We have shown that Re-diselenoether gave both mono- and bis-guanine Re adducts, the species assumed to be responsible for the DNA intrastrand lesions.
authors.affiliation: Société de Coordination de Recherches Thérapeutiques, Algajola, France, philippe.collery@gmail.com.
authors.forename: Philippe
authors.initials: P
authors.lastname: Collery
authors.forename: Ahmed
authors.initials: A
authors.lastname: Mohsen
authors.forename: Anthony
authors.initials: A
authors.lastname: Kermagoret
authors.forename: Samantha
authors.initials: S
authors.lastname: Corre
authors.forename: Gérard
authors.initials: G
authors.lastname: Bastian
authors.forename: Alain
authors.initials: A
authors.lastname: Tomas
authors.forename: Ming
authors.initials: M
authors.lastname: Wei
authors.forename: François
authors.initials: F
authors.lastname: Santoni
authors.forename: Nadia
authors.initials: N
authors.lastname: Guerra
authors.forename: Didier
authors.initials: D
authors.lastname: Desmaële
authors.forename: Jean
authors.initials: J
authors.lastname: d'Angelo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008819:Mice, Nude; D012211:Rhenium / Q000494:pharmacology / Q000627:therapeutic use*; D012643:Selenium / Q000494:pharmacology / Q000627:therapeutic use*; D014018:Tissue Distribution; D047368:Tumor Burden / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; C116701:9-methylguanine; D006147:Guanine; D012211:Rhenium; D012643:Selenium