title: Lactobionic acid reduces body weight gain in diet-induced obese rats by targeted inhibition of galectin-1.
abstract: Galectin-1 (GAL1), an animal lectin with a carbohydrate recognition domain, is known for its roles in cancer, tumor progression, as well as obesity and related complications. Here, we investigated the anti-obesity effect of lactobionic acid (LBA), a GAL1 inhibitor, both in vitro and in vivo. LBA treatment significantly reduced lipogenic capacity of both 3T3-L1 and HIB1B adipocytes through down-regulation of major adipogenic transcription factors at both mRNA and protein levels. Moreover, oral administration and intraperitoneal injection of LBA in Sprague-Dawley male rats fed a high fat diet caused marked reduction of body weight gain as well as improvement of related metabolic parameters. Important lipogenic transcription factors were also down-regulated in LBA-treated rats, resulting in attenuated lipogenesis and fat accumulation. Collectively, pharmaceutical targeting of GAL1 using LBA would be a novel therapeutic approach for the treatment of obesity.
authors.affiliation: Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, 712-714, Republic of Korea.
authors.forename: Rajib
authors.initials: R
authors.lastname: Mukherjee
authors.affiliation: Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, 712-714, Republic of Korea. Electronic address: jwyun@daegu.ac.kr.
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Yun
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D004032:Diet; D004187:Disaccharides / Q000494:pharmacology*; D037483:Galectin 1 / Q000037:antagonists & inhibitors*; D050155:Lipogenesis; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000628:therapy*; D051381:Rats; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D004187:Disaccharides; D037483:Galectin 1; C005608:lactobionic acid
keywords: Adipose tissue; Galectin-1; Lactobionic acid; Lipogenesis; Obesity