title: Intraoperative biomarkers in renal transplantation.
abstract: The emerging need for biomarkers in the management of renal transplantation is highlighted by the severity of related complications such as acute renal failure and ischaemia/reperfusion injury (IRI) and by the increasing efforts to identify novel markers of these events to predict and monitor delayed graft function (DGF) and long-term outcome. In clinical studies candidate markers such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and interleukin-18 have been demonstrated to be valid biomarkers with high predictive value for DFG in a post-transplant setting. However, studies investigating biomarkers for early diagnosis of IRI and assumable DGF as well as identification of potential graft recipients at increased risk at the time point of transplantation lack further confirmation and translation into clinical practice. This review summarizes the current literature on the value of IRI biomarkers in outcome prediction following renal transplantation as well their capacity as surrogate end points from an intraoperative perspective.
authors.affiliation: Department of Neurosurgery with Pediatric Neurosurgery, Charité-University Medicine, Campus Virchow, Berlin, Germany.|Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, Dresden, Germany.
authors.forename: Laura-Nanna
authors.initials: LN
authors.lastname: Lohkamp
authors.affiliation: Department for General, Visceral and Transplantation Surgery, Charité-University Medicine, Campus Virchow, Berlin, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Öllinger
authors.affiliation: Department of Clinical Pathobiochemistry, Medical Faculty Carl Gustav Carus Technische Universität Dresden, Dresden, Germany.|Paul-Langerhans Institute Dresden, German Center for Diabetes Research, Dresden, Germany.
authors.forename: Antonios
authors.initials: A
authors.lastname: Chatzigeorgiou
authors.affiliation: Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, Dresden, Germany.|Department of Neurology, University Hospital Carl Gustav Carus Technische Universität Dresden, Dresden, Germany.
authors.forename: Ben Min-Woo
authors.initials: BM
authors.lastname: Illigens
authors.affiliation: Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, Dresden, Germany.|Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Timo
authors.identifier: http://orcid.org/0000-0003-2196-5904
authors.initials: T
authors.lastname: Siepmann
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D051799:Delayed Graft Function / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D042241:Early Diagnosis; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D016343:Monitoring, Intraoperative / Q000379:methods*; D011237:Predictive Value of Tests; D020127:Recovery of Function; D015427:Reperfusion Injury / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers
keywords: biomarkers; ischaemia/reperfusion injury; prediction; renal transplantation