title: A new phenolic compound with antioxidant activity from the branches and leaves of Pyrus pashia.
abstract: The branches and leaves of Pyrus pashia are used to cure abdominal pain and diarrhoea in Chinese folk medicine. A new phenilic compound, 4-O-β-d-glucopyranosylbenzyl-benzoate ester (1), along with 21 known ones (2-22) were isolated from the branches and leaves of this plant. Compounds 2 and 3 displayed remarkable antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl radical (IC50 = 13.26 ± 0.04 μM, 13.28 ± 0.11 μM, respectively), which were at the same grade as positive control rutin. The caffeoyl group in compounds 2 and 3 was supposed to play an important role in the antioxidant activities.
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , Yunnan 650091 , China.
authors.forename: Zhen-Jie
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: b Central Laboratory , No 1 Hospital Affiliated Yunnan University of Traditional Chinese Medicine , Kunming 650021 , China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
authors.affiliation: b Central Laboratory , No 1 Hospital Affiliated Yunnan University of Traditional Chinese Medicine , Kunming 650021 , China.
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Wan
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , Yunnan 650091 , China.
authors.forename: Le
authors.initials: L
authors.lastname: Cai
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , Yunnan 650091 , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , Yunnan 650091 , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
authors.affiliation: a Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology , Yunnan University , Kunming , Yunnan 650091 , China.
authors.forename: Zhong-Tao
authors.initials: ZT
authors.lastname: Ding
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001565:Benzoates / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts; D018515:Plant Leaves / Q000737:chemistry; D031989:Pyrus / Q000737:chemistry*
chemical_list: C000611769:4-O-beta-D-glucopyranosylbenzyl-benzoate; D000975:Antioxidants; D001565:Benzoates; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts
keywords: Pyrus pashia; antioxidant activity; phenolic constituents