title: DNA-protein crosslink repair.
abstract: DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown. This has changed with discoveries made in yeast and Xenopus laevis that revealed a protease-based DNA-repair pathway specific for DPCs. Importantly, mutations in the gene encoding the putative human homologue of a yeast DPC protease cause a human premature ageing and cancer predisposition syndrome. Thus, DPC repair is a previously overlooked genome-maintenance mechanism that may be essential for tumour suppression.
authors.affiliation: Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. Present address: The Francis Crick Institute, Clare Hall Laboratory, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK.
authors.forename: Julian
authors.initials: J
authors.lastname: Stingele
authors.affiliation: Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Jentsch
mesh_terms: D000818:Animals; D018736:DNA Adducts / Q000235:genetics* / Q000378:metabolism; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans; D010447:Peptide Hydrolases / Q000502:physiology
chemical_list: D018736:DNA Adducts; D010447:Peptide Hydrolases