title: FGF23 regulation of renal tubular solute transport.
abstract: OBJECTIVE
  Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress phosphate reabsorption in the kidney. The purpose of this review was to highlight the recent advances in the area of FGF23-regulated solute transport in the kidney.
  
  
  RESULTS
  Recent evidence suggests that FGF23 suppresses phosphate reabsorption in renal proximal tubular epithelium by a Klotho-dependent, FGF receptor (FGFR)-1 and FGFR4-mediated signaling mechanism that may also involve Janus kinase 3. Moreover, it was recently established that FGF23 signaling in the distal renal tubule targets with-no-lysine kinase-4 (WNK4), a key molecule in the regulation of solute transport in the distal nephron. By targeting WNK4, FGF23 has been shown to increase the membrane abundance of the epithelial calcium channel TRPV5 and of the sodium-chloride cotransporter NCC, resulting in augmented renal calcium and sodium reabsorption.
  
  
  CONCLUSIONS
  Significant progress has been made in the further characterization of the signaling pathways involved in the FGF23-induced inhibition of phosphate transport in proximal tubular epithelium, and major new functions of FGF23 in solute transport have been discovered in distal renal tubules. The calcium- and sodium-conserving functions of FGF23 may have major implications for the pathophysiology of cardiovascular diseases. VIDEO ABSTRACT.
authors.affiliation: University of Veterinary Medicine Vienna, Vienna, Austria.
authors.forename: Reinhold G
authors.initials: RG
authors.lastname: Erben
authors.forename: Olena
authors.initials: O
authors.lastname: Andrukhova
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D007686:Kidney Tubules, Distal / Q000378:metabolism*; D000090265:Klotho Proteins; D010710:Phosphates / Q000378:metabolism; D049992:Sodium Chloride Symporters / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D010710:Phosphates; D049992:Sodium Chloride Symporters; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002118:Calcium