title: Does Extended-Release Liposomal Bupivacaine Better Control Pain Than Bupivacaine After Total Knee Arthroplasty (TKA)? A Prospective, Randomized Clinical Trial.
abstract: Liposomal bupivacaine periarticular injection (PAI) offers sustained bupivacaine release after TKA, but few prospective independent studies exist. In this prospective, blinded study, liposomal bupivacaine was randomized against bupivacaine and incorporated into a comprehensive multimodal pain management protocol. 111 primary TKAs were randomized to receive PAI: 58 patients received 266 mg (20cc) liposomal bupivacaine mixed with 75 mg (30cc) 0.25% bupivacaine, and 53 patients received 150 mg (60cc) 0.25% bupivacaine. Visual analog pain scores and narcotic use were determined. No pain score differences occurred between study and control patients: Day 1: 4.5/4.6 (P=0.73); Day 2: 4.4/4.8 (P=0.27); or Day 3: 3.5/3.7 (P=0.58). Narcotic use was similar during hospitalization, 51.8/54.2 (P=0.34). The study medication costs $285, and the control medication costs $2.80. This finding does not justify the routine use of liposomal bupivacaine.
authors.affiliation: St. Louis Joint Replacement Institute, St. Louis, Missouri.
authors.forename: William C
authors.initials: WC
authors.lastname: Schroer
authors.affiliation: St. Louis Joint Replacement Institute, St. Louis, Missouri.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Diesfeld
authors.affiliation: St. Louis Joint Replacement Institute, St. Louis, Missouri.
authors.forename: Angela R
authors.initials: AR
authors.lastname: LeMarr
authors.affiliation: St. Louis Joint Replacement Institute, St. Louis, Missouri.
authors.forename: Diane J
authors.initials: DJ
authors.lastname: Morton
authors.affiliation: St. Louis Joint Replacement Institute, St. Louis, Missouri.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Reedy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000008:administration & dosage*; D019645:Arthroplasty, Replacement, Knee; D002045:Bupivacaine / Q000008:administration & dosage* / Q000191:economics; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular / Q000191:economics; D008081:Liposomes / Q000008:administration & dosage* / Q000191:economics; D008297:Male; D008875:Middle Aged; D059408:Pain Management / Q000191:economics / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D000779:Anesthetics, Local; D003692:Delayed-Action Preparations; D008081:Liposomes; D002045:Bupivacaine
keywords: bupivacaine; multimodal; pain management; periarticular injection; total knee arthroplasty