title: The efficacy and safety of rabbit anti-thymocyte globulin vs rabbit anti-T-lymphocyte globulin in peripheral blood stem cell transplantation from unrelated donors.
abstract: The comparative efficacy and safety of antithymocyte globulin (ATG) at fixed doses in patients undergoing allogeneic peripheral blood stem cell transplantation from unrelated donors (UR-PBSCT) has not been evaluated. In this study, the records of 56 patients and 54 patients who received pre-transplant ATG-Thymoglobulin (ATG-T) at a total dose of 10 mg/kg and ATG- Fresenius (ATG-F) at a total dose of 20 mg/kg, respectively, were retrospectively analyzed. ATG-F patients had a significantly lower probability of developing chronic graft-vs-host disease (cGVHD) than those treated with ATG-T (p = 0.04). ATG-F was associated with a non-significant trend towards lower relapse rates and higher survival at 3- and 5-years of follow-up compared with ATG-T. A significantly greater proportion of ATG-T patients experienced chills and high fever than ATG-F patients (p < 0.01). The current findings suggest that ATG-F may more effectively and safely prevent cGVHD without increasing relapse rates in patients undergoing UR-PBSCT.
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.|b Department of Hematology , Hainan Branch of Chinese PLA General Hospital , Hainan province , PR China.
authors.forename: Wenrong
authors.initials: W
authors.lastname: Huang
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Cao
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Zhanxiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Honghua
authors.initials: H
authors.lastname: Li
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Bo
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Wang
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhu
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Dou
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Qunshun
authors.initials: Q
authors.lastname: Wang
authors.affiliation: a Department of Hematology and BMT , Chinese PLA General Hospital , Beijing , PR China.
authors.forename: Chunji
authors.initials: C
authors.lastname: Gao
keywords: ATG-Fresenius; ATG-Thymoglobulin; Unrelated donor; graft-vs-host disease; peripheral blood stem cell transplantation