title: Sustained release of VH and rhBMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair.
abstract: Nanoporous magnesium-zinc-silicon (n-MZS) xerogels with a pore size ∼4 nm, a surface area of 718 cm(2)/g, and a pore volume of 1.24 cm(3)/g were synthesized by a sol-gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium-zinc-silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.
authors.affiliation: Department of Pharmacy, Shanghai Xuhui Dahua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Fengqian
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Wen
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Pharmacy, Shanghai Xuhui Dahua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Department of Pharmacy, Shanghai Xuhui Dahua Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.
authors.forename: Gan
authors.initials: G
authors.lastname: Weng
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Hong
authors.affiliation: School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry / Q000493:pharmacokinetics; D002460:Cell Line; D005782:Gels / Q000737:chemistry*; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D058608:Nanopores; D010019:Osteomyelitis; D011994:Recombinant Proteins / Q000737:chemistry / Q000493:pharmacokinetics; D012825:Silicon / Q000737:chemistry; D014640:Vancomycin / Q000737:chemistry / Q000493:pharmacokinetics; D015032:Zinc / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D005782:Gels; D011994:Recombinant Proteins; D014640:Vancomycin; D008274:Magnesium; D015032:Zinc; D012825:Silicon
keywords: bactericidal activity; bone regeneration; cytocompatibility; drugs; nanoporous xerogels; osteomyelitis; sustained release