title: Hepcidin and its potential clinical utility.
abstract: A number of pathophysiological conditions are related to iron metabolism disturbances. Some of them are well known, others are newly discovered or special. Hepcidin is a newly identified iron metabolism regulating hormone, which could be a promising biomarker for many disorders. In this review, we provide background information about mammalian iron metabolism, cellular iron trafficking, and the regulation of expression of hepcidin. Beside these molecular biological processes, we summarize the methods that have been used to determine blood and urine hepcidin levels and present those pathological conditions (cancer, inflammation, neurological disorders) when hepcidin measurement may have clinical relevance.
authors.affiliation: Department of Laboratory Medicine, Faculty of Medical Sciences, University of Pécs, 7624 Ifjusag Street 13. Pecs, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Miseta
authors.affiliation: Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences, University of Pécs, 7624 Ifjusag Street 13. Pecs, Hungary.
authors.forename: Judit
authors.initials: J
authors.lastname: Nagy
authors.affiliation: Department of Laboratory Medicine, Faculty of Medical Sciences, University of Pécs, 7624 Ifjusag Street 13. Pecs, Hungary.
authors.forename: Tamas
authors.initials: T
authors.lastname: Nagy
authors.affiliation: Department of Forensic Medicine, Faculty of Medical Sciences, University of Pécs, 7624 Szigeti Street 12. Pecs, Hungary.
authors.forename: Viktor Soma
authors.initials: VS
authors.lastname: Poór
authors.affiliation: Department of Medical Biology, Faculty of Medical Sciences, University of Pécs, 7624 Szigeti Street 12. Pecs, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Fekete
authors.affiliation: Department of Pharmaceutical Biology, Faculty of Medical Sciences, University of Pécs, 7624 Rokus Street 2. Pecs, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Sipos
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D064451:Hepcidins / Q000378:metabolism* / Q000494:pharmacology*; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000097:blood / Q000188:drug therapy
chemical_list: D015415:Biomarkers; D064451:Hepcidins; D007501:Iron
keywords: diagnostics; hepcidin; iron homeostasis; liver; prohepcidin