title: Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure.
abstract: One of the most common diseases of old age in modern societies is glaucoma. It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye. As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important. The chemical composition of the dried Cornelian cherry (Cornus mas L.) polar, iridoid-polyphenol-rich fraction was investigated. Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components. Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction. In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated. We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol. About a 25% decrease in IOP was observed within the first 3 hours of use.
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland ; Ophthalmology Clinic, Uniwersytecki Szpital Kliniczny, 50-556 Wrocław, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Szumny
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sozański
authors.affiliation: Department of Fruit and Vegetables Technology, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
authors.forename: Alicja Z
authors.initials: AZ
authors.lastname: Kucharska
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Dziewiszek
authors.affiliation: Arboretum and Institute of Physiography in Bolestraszyce, 37-722 Bolestraszyce, Poland ; Department of Turism & Recreation, University of Rzeszow, 35-959 Rzeszów, Poland.
authors.forename: Narcyz
authors.initials: N
authors.lastname: Piórecki
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Magdalan
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Chlebda-Sieragowska
authors.affiliation: Department of Environment Hygiene and Animal Welfare, Wrocław University of Environmental and Life Sciences, 51-630 Wrocław, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Kupczynski
authors.affiliation: Department of Pharmacology, Wrocław Medical University, 50-345 Wrocław, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Szeląg
authors.affiliation: Department of Chemistry, Wrocław University of Environmental and Life Science, 50-375 Wrocław, Poland.
authors.forename: Antoni
authors.initials: A
authors.lastname: Szumny