title: Subcategorization of Suspicious Breast Lesions (BI-RADS Category 4) According to MRI Criteria: Role of Dynamic Contrast-Enhanced and Diffusion-Weighted Imaging.
abstract: OBJECTIVE
  The purposes of this study were to investigate whether dynamic contrast-enhanced MRI is adequate for subcategorization of suspicious lesions (BI-RADS category 4) and to evaluate whether use of DWI improves diagnostic performance.
  
  
  METHODS
  The study group was composed of 103 suspicious lesions found in 83 subjects. Patient ages and lesion sizes were compiled, and two radiologists reanalyzed the images; subcategorized the findings as BI-RADS 4A, 4B, or 4C; and calculated apparent diffusion coefficient (ADC) values. The stratified variables were tested by univariate analysis and inserted in two multivariate predictive models, which were used to generate ROC curves and compare AUCs. Positive predictive values (PPVs) for each subcategory and ADC level were calculated, and interobserver agreement was tested.
  
  
  RESULTS
  Forty-four (42.7%) suspicious findings proved malignant. Except for age (p = 0.08), all stratified predictor variables were significant in univariate analyses (p < 0.01). Logistic regression models did not differ substantially after comparison of the ROC curves (p = 0.09), but the one including ADC values was slightly better: AUC of 0.89 (95% CI, 0.82-0.95) against AUC of 0.85 (95% CI, 0.78-0.93). PPV increased progressively in each BI-RADS 4 subcategory (4A, 0.15; 4B, 0.37; 4C, 0.84). ADC values of 1.10 × 10(-3) mm(2)/s or less had the second highest PPV (0.77). Interobserver agreement was substantial at a kappa value of 0.80 (95% CI, 0.70-0.90; p < 0.01).
  
  
  CONCLUSIONS
  Risk stratification of suspicious lesions (BI-RADS category 4) can be satisfactorily performed with DCE-MRI and slightly improved when DWI is introduced.
authors.affiliation: 1 Department of Diagnostic Imaging, Clínica de Assistência à Mulher, Grupo CAM, Avenida ACM, 237, Ed. Prof. Carlos Aristides Maltez, Itaigara, Salvador, Bahia, Brazil 41825-000.
authors.forename: João Ricardo
authors.initials: JR
authors.lastname: Maltez de Almeida
authors.affiliation: 1 Department of Diagnostic Imaging, Clínica de Assistência à Mulher, Grupo CAM, Avenida ACM, 237, Ed. Prof. Carlos Aristides Maltez, Itaigara, Salvador, Bahia, Brazil 41825-000.
authors.forename: André Boechat
authors.initials: AB
authors.lastname: Gomes
authors.affiliation: 2 Department of Biomedicine, Bahiana School of Medicine and Public Health, Campus Brotas, Salvador, Bahia, Brazil.
authors.forename: Thomas Pitangueira
authors.initials: TP
authors.lastname: Barros
authors.affiliation: 3 Department of Pathology, Clínica de Assistência à Mulher, Grupo CAM, Salvador, Bahia, Brazil.
authors.forename: Paulo Eduardo
authors.initials: PE
authors.lastname: Fahel
authors.affiliation: 4 Department of Medicine, Bahiana School of Medicine and Public Health, Campus Brotas, Brotas, Salvador, Bahia, Brazil.
authors.forename: Mário
authors.initials: M
authors.lastname: de Seixas Rocha
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D003287:Contrast Media; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008536:Meglumine; D008875:Middle Aged; D009942:Organometallic Compounds; D012189:Retrospective Studies; D018570:Risk Assessment
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine
keywords: BI-RADS; DWI; breast MRI; breast cancer; suspicious breast lesions