title: Symptomatic intracranial vertebral artery atherosclerotic stenosis (≥70%) with concurrent contralateral vertebral atherosclerotic diseases in 88 patients treated with the intracranial stenting.
abstract: OBJECTIVE
  To investigate the safety, effect and instent restenosis rate of Wingspan stenting in treating patients with intracranial vertebral artery atherosclerotic stenosis (70-99%) concurrent with contralateral vertebral artery atherosclerotic diseases.
  
  
  METHODS
  Eighty-eight patients with severe symptomatic intracranial vertebral artery atherosclerotic stenosis (≥70%) combined with contralateral vertebral artery atherosclerotic diseases were treated with the Wingpsan stent. All the baseline, cerebral angiography, success rate, perioperative complications, clinical and imaging follow-up data were prospectively analyzed.
  
  
  RESULTS
  The success rate of stenting was 100%, and the mean stenotic rate was reduced from prestenting (84.9±6.8)% to poststenting (17.2±5.9)%. The perioperative stroke rate was 1.1%. Among eighty patients (90.9%) with clinical follow-up 8-62 months (mean 29.3±17.2) poststenting, five (6.3%) had posterior circulation TIA only, three (3.8%) had mild stroke in the posterior circulation but recovered completely, and another five patients greater than 70 years old died of non-ischemic stroke. Imaging follow-up in 46 patients (52.3%) 5-54 months (mean 9.9±9.9) following stenting revealed instent restenosis in 12 patients (26.1%) including 7 (58.3%) symptomatic restenosis. Age and residual stenosis were the two factors to significantly (P<0.05) affect instent restenosis.
  
  
  CONCLUSIONS
  Wingspan stenting in the intracranial vertebral artery atherosclerotic stenosis combined with contralateral vertebral artery atherosclerotic diseases has a low perioperative stroke rate and a good preventive effect on long-term ischemic stroke, but the instent restenosis rate is a little high.
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Zi-Liang
authors.initials: ZL
authors.lastname: Wang
authors.affiliation: Department of Medical Research Shijiazhuang First Hospital, Hebei Medical University, China.
authors.forename: Bu-Lang
authors.initials: BL
authors.lastname: Gao
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China. Electronic address: litianxiaod@163.com.
authors.forename: Tian-Xiao
authors.initials: TX
authors.lastname: Li
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Cai
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Liang-Fu
authors.initials: LF
authors.lastname: Zhu
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Bai
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Jiang-Yu
authors.initials: JY
authors.lastname: Xue
authors.affiliation: Stroke Center, Henan Provincial People's Hospital, Zhengzhou University, China.
authors.forename: Zhao-Shuo
authors.initials: ZS
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D002533:Cerebral Angiography; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents / Q000706:statistics & numerical data*; D020521:Stroke / Q000517:prevention & control; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014715:Vertebrobasilar Insufficiency / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D055815:Young Adult
keywords: Atherosclerotic stenosis; Contralateral vertebral disease; Instent restenosis; Intracranial vertebral artery; Wingspan stent