title: Primary central chondrosarcoma of long bone, limb girdle and trunk: Analysis of 174 cases by numerical scoring on histology.
abstract: The aims of this study were: (i) to elucidate clinicopathological characteristics of pcCHS of long bones (L), limb girdles (LG) and trunk (T) in Japan; (ii) to investigate predictive pathological findings for outcome of pcCHS of L, LG and T, objectively; and (iii) to elucidate a discrepancy of grade between biopsy and resected specimens. Clinicopathological profiles of 174 pcCHS (79 male, 95 female), of L, LG, and T were retrieved. For each case, a numerical score was given to 18 pathological findings. The average age was 50.5 years (15-80 years). Frequently involved sites were femur, humerus, pelvis and rib. The 5-year and 10-year disease-specific survival (DSS) rates [follow-up: 1-258 months (average 65.5)] were 87.0% and 80.4%, respectively. By Cox hazards analysis on pathological findings, age, sex and location, histologically higher grade and older age were unfavorable predictors, and calcification was a favorable predictor in DSS. The histological grade of resected specimen was higher than that of biopsy in 37.7% (26/69 cases). In conclusion, higher histological grade and older age were predictors for poor, but calcification was for good prognosis. Because there was a discrepancy in grade between biopsy and resected specimens, comprehensive evaluation is necessary before definitive operation for pcCHS.
authors.affiliation: Department of Pathology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Konishi
authors.affiliation: Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Nakashima
authors.affiliation: Department of Pathology, Osaka National Hospital, Osaka, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Mano
authors.affiliation: Department of Pathology, Osaka Medical Center of Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomita
authors.affiliation: Department of Mathematics, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Ikumitsu
authors.initials: I
authors.lastname: Nagasaki
authors.affiliation: Department of Orthopedics, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kubo
authors.affiliation: Department of Orthopedic Surgery, Osaka Medical Center of Cancer and Cardiovascular Diseases, Osaka, Japan.
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Araki
authors.affiliation: Department of Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Haga
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Toguchida
authors.affiliation: Department of Orthopaedic Surgery, Osaka National Hospital, Osaka, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ueda
authors.affiliation: Department of Pathology, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Sakuma
authors.affiliation: Department of Orthopedic Surgery, Hyogo Cancer Center, Akashi, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Imahori
authors.affiliation: Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Morii
authors.affiliation: Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Yoshitane
authors.initials: Y
authors.lastname: Tsukamoto
authors.affiliation: Department of Orthopaedic Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Futani
authors.affiliation: Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Wakasa
authors.affiliation: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hoshi
authors.affiliation: Department of Pathology, Otsu Municipal Hospital, Otsu, Japan.
authors.forename: Shinshichi
authors.initials: S
authors.lastname: Hamada
authors.affiliation: Department of Orthopedic Surgery, Otsu Municipal Hospital, Otsu, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takeshita
authors.affiliation: Department of Pathology, Osaka City General Hospital, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Orthopedic Surgery, Osaka City General Hospital, Osaka, Japan.
authors.forename: Masanari
authors.initials: M
authors.lastname: Aono
authors.affiliation: Department of Pathology, Matsushita Memorial Hospital, Moriguchi, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawabata
authors.affiliation: Department of Orthopedic Surgery, Matsushita Memorial Hospital, Moriguchi, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Murata
authors.affiliation: Department of Pathology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan.
authors.forename: Kanade
authors.initials: K
authors.lastname: Katsura
authors.affiliation: Department of Pathology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Urata
authors.affiliation: Department of Orthopedic Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueda
authors.affiliation: Department of Pathology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000473:pathology*; D002813:Chondrosarcoma / Q000473:pathology*; D005260:Female; D005269:Femur / Q000473:pathology; D006652:Histological Techniques; D006801:Humans; D006811:Humerus / Q000473:pathology; D007564:Japan; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
keywords: grade; pathology; primary central chondrosarcoma; prognosis; statistical analysis