title: Mutual interaction between BCL6 and miRNAs contributing to the pathogenesis of various cancers.
abstract: MicroRNA (miRNA), a class of non-protein-coding RNAs, plays a critical role in many cellular processes, such as invasion, proliferation and migration, and also function in disease pathology. The transcription factor and proto-oncogene B cell CLL/lymphoma 6 (BCL6) is aberrantly expressed in various cancers. An increasing body of evidence has demonstrated that miRNAs and BCL6 can target one another and mutually adjust their expression which are of great importance in the pathogenesis of various cancers. In this report, we summarize the mutual interaction between miRNAs and BCL6, which have been studied in cancers, highlighting their mechanisms and potential therapeutic targets in cancers.
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People's Republic of China.|The Battalion 10 of Cadet Brigade, Third Military Medical University, Chongqing, 400038, People's Republic of China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wei
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People's Republic of China.|Third Military Medical University, Chongqing, 400038, People's Republic of China.
authors.forename: W
authors.initials: W
authors.lastname: Gao
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People's Republic of China. nibing@tmmu.edu.cn.
authors.forename: B
authors.initials: B
authors.lastname: Ni
authors.affiliation: Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People's Republic of China. tianyi19831015@hotmail.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000090063:Proto-Oncogene Mas; D051560:Proto-Oncogene Proteins c-bcl-6
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; C000715470:MAS1 protein, human; D035683:MicroRNAs; D000090063:Proto-Oncogene Mas; D051560:Proto-Oncogene Proteins c-bcl-6
keywords: BCL6; Cancer; Oncogene; miRNA