title: Out-of-Plane Plasmonic Antennas for Raman Analysis in Living Cells.
abstract: Out-of-plane plasmonic nanoantennas protruding from the substrate are exploited to perform very sensitive surface enhanced Raman scattering analysis of living cells. Cells cultured on three-dimensional surfaces exhibit tight adhesion with nanoantenna tips where the plasmonic hot-spot resides. This fact provides observable cell adhesion sites combined with high plasmonic enhancement, resulting in an ideal system for Raman investigation of cell membranes.
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: La Rocca
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
authors.forename: Gabriele C
authors.initials: GC
authors.lastname: Messina
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Dipalo
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
authors.forename: Victoria
authors.initials: V
authors.lastname: Shalabaeva
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genoa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Angelis
mesh_terms: D000199:Actins / Q000737:chemistry; D000818:Animals; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D002470:Cell Survival; D004574:Electromagnetic Fields; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles; D051379:Mice; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D041681:NIH 3T3 Cells; D049329:Nanostructures; D036103:Nanotechnology; D010316:Particle Size; D012834:Silver / Q000737:chemistry; D012984:Software; D019265:Spectroscopy, Near-Infrared; D013059:Spectrum Analysis, Raman / Q000379:methods*; D020349:Surface Plasmon Resonance
chemical_list: D000199:Actins; D012834:Silver; D006046:Gold
keywords: 3D plasmonic nanoantennas; Raman spectroscopy; bio-interfaces; surface enhanced Raman scattering (SERS)