title: The Effect of Decreasing Flow Rate on Cerebral Hemodynamics During Veno-Arterial Extracorporeal Membrane Oxygenation in Piglets.
abstract: To explore the influence of decreasing flow rate on cerebral hemodynamics during veno-arterial extracorporeal membrane oxygenation (va-ECMO), six normoxemic and six hypoxemic piglets were put on va-ECMO. The ECMO flow rate was decreased from the maximal achievable level to 50 mL min1 with steps of 50 mL min1 every 2 minutes. Changes in mean arterial blood pressure (MABP), left common carotid artery blood flow (Qcar), and other physiologic variables were continuously measured. Changes in concentrations of oxyhemoglobin and deoxyhemoglobin were measured using near infrared spectrophotometry (NIRS). Changes in difference between cerebral oxygen hemoglobin and deoxyhemoglobin concentration (ΔcHbD) and total hemoglobin concentration (ΔctHb) were calculated. ΔcHbD represents changes in cerebral blood flow (CBF), and ΔctHb reflects changes in cerebral blood volume (CBV). Data analysis was performed using mixed models and demonstrated a significant positive correlation between ECMO flow and, respectively, MABP (r = 0.7, p < 0.001), Qcar (r = 0.7, p < 0.001), cHbD (r = 0.8, p < 0.001), and ctHb (r = 0.7, p < 0.001). There was no significant relation between oxygenation state preceding ECMO and Qcar, cHbD, and ctHb during decreasing ECMO flow rate. We conclude that decreasing ECMO flow rate ultimately leads to concurrent decrease in MABP, CBF, and CBV.
authors.affiliation: From the *Section Neonatology, Department of Pediatrics, †Department of Radiology, Medical Ultrasound Imaging Center, ‡Section Biostatistics, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
authors.forename: Luella C
authors.initials: LC
authors.lastname: Gerrits
authors.forename: Arno F J
authors.initials: AF
authors.lastname: van Heijst
authors.forename: Jeroen C W
authors.initials: JC
authors.lastname: Hopman
authors.forename: Anton F J
authors.initials: AF
authors.lastname: de Haan
authors.forename: Kian D
authors.initials: KD
authors.lastname: Liem
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D006439:Hemodynamics / Q000502:physiology*; D013055:Spectrophotometry, Infrared; D034421:Sus scrofa