title: Cinnamomum cassia: an implication of serotonin reuptake inhibition in animal models of depression.
abstract: The aim of the study was to explore the traditional use of Cinnamomum cassia against depression. The standardised methanolic extract of the bark of C. cassia was evaluated for antidepressant activity using various behavioural tests, i.e. tail suspension test (TST), forced swim test (FST) and locomotor activity test. The serotonergic and noradrenergic modulation was assessed using 5-hydroxytryptophan (5-HTP)-induced head twitches and yohimbine potentiation tests, respectively. The fluoxetine and phenelzine were used as positive controls in the study. The C. cassia extract significantly decreased the immobility time in TST (maximum effective dose tested was 50 mg/kg) while no effect was observed in FST and locomotor activity test. The extract significantly increased the 5-HTP-induced head twitches while yohimbine-induced lethality remained unaltered. The aforementioned results are similar to that caused by fluoxetine. The standardised methanolic extract of C. cassia demonstrated antidepressant activity that can be attributed to rise in serotonin levels.
authors.affiliation: a Department of Pharmacy , COMSATS Institute of Information Technology , Abbottabad 22060 , K.P.K , Pakistan.
authors.forename: Wahid
authors.initials: W
authors.lastname: Zada
authors.affiliation: a Department of Pharmacy , COMSATS Institute of Information Technology , Abbottabad 22060 , K.P.K , Pakistan.
authors.forename: Sara
authors.initials: S
authors.lastname: Zeeshan
authors.affiliation: b H.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi , Karachi , Pakistan.
authors.forename: Huma Aslam
authors.initials: HA
authors.lastname: Bhatti
authors.affiliation: a Department of Pharmacy , COMSATS Institute of Information Technology , Abbottabad 22060 , K.P.K , Pakistan.
authors.forename: Wajahat
authors.initials: W
authors.lastname: Mahmood
authors.affiliation: a Department of Pharmacy , COMSATS Institute of Information Technology , Abbottabad 22060 , K.P.K , Pakistan.
authors.forename: Khalid
authors.initials: K
authors.lastname: Rauf
authors.affiliation: a Department of Pharmacy , COMSATS Institute of Information Technology , Abbottabad 22060 , K.P.K , Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D005473:Fluoxetine / Q000494:pharmacology; D019417:Hindlimb Suspension; D008297:Male; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000032:analysis; D017367:Selective Serotonin Reuptake Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D013550:Swimming; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D010936:Plant Extracts; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D015016:Yohimbine
keywords: C. cassia; antidepressant; fluoxetine; serotonin