title: Is dabigatran efficacy enough to prevent stroke in atrial fibrillation patient with high CHADS2 score during peri-procedural catheter radiofrequency ablation? A case report with literature review.
abstract: Atrial fibrillation (AF) is a major cause of thromboembolic (TE) events including stroke and transient ischemic attacks, catheter radiofrequency ablation (CA) has been demonstrated to effectively eliminate AF in majority of patients. During the peri-procedural CA of AF, dabigatran, a reversible direct thrombin inhibitor, has been proved as safe and efficacy as warfarin in the prevention of thromboembolic complication. However, for patients with CHADS2 score ≥3, sometimes dabigatran may not be an ideal substitute of warfarin. The current study presents delayed stroke occurred in a middle-aged AF patient with high CHADS2 score who had undergone successful CA of AF being on dabigatran, trans esophageal echocardiogram (TEE) detected a clot in the left atrium appendage (LAA) and magnetic resonance image (MRI) indicated stroke of left basal ganglia, therefore anticoagulant was switched to warfarin with well controlled international normalization ratio (INR) ranging from 2.0-3.0 and the patient eventually recovered without any TE events during the subsequent follow-up.
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Xiang-Min
authors.initials: XM
authors.lastname: Shi
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Fu-Kun
authors.initials: FK
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Guo
authors.affiliation: Department of Cardiology, The General Hospital of PLA Beijing 100853, China.
authors.forename: Zhao-Liang
authors.initials: ZL
authors.lastname: Shan
keywords: Atrial fibrillation; catheter radiofrequency ablation; dabigatran; left atrium appendage; thromboembolic events