title: The next steps in improving the outcomes of advanced ovarian cancer.
abstract: Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication. Second, acquisition of chemotherapy resistance results in untreatable progressive disease. Advances in treatment of advanced ovarian cancer involve a spectrum of interventions including improvements in frontline debulking surgery and combination chemotherapy. Anti-angiogenic factors have been shown to have activity in frontline and recurrent disease while novel chemotherapeutic agents and targeted treatments are in development particularly for disease that is resistant to platinum-based chemotherapy. These developments aim to improve the progression-free and overall survival of women with advanced ovarian cancer.
authors.affiliation: Department of Medical Oncology, Hammersmith Hospital, Imperial College NHS, London, UK.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Openshaw
authors.affiliation: Department of Medical Oncology, Hammersmith Hospital, Imperial College NHS, London, UK.
authors.forename: Christina
authors.initials: C
authors.lastname: Fotopoulou
authors.affiliation: Department of Medical Oncology, Hammersmith Hospital, Imperial College NHS, London, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Blagden
authors.affiliation: Department of Medical Oncology, Hammersmith Hospital, Imperial College NHS, London, UK.
authors.forename: Hani
authors.initials: H
authors.lastname: Gabra
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D014943:Global Health; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D020360:Neoadjuvant Therapy / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic; D016387:Women's Health
keywords: BRCA; PARP inhibitors; TP53; adjuvant chemotherapy; debulking surgery; immunotherapy; intraperitoneal chemotherapy; neoadjuvant chemotherapy; ovarian cancer; platinum resistance