title: Divergent brain functional network alterations in dementia with Lewy bodies and Alzheimer's disease.
abstract: The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer's disease (AD), suggesting a divergence between these diseases in terms of brain network organization. To fully understand this, we studied functional networks from resting-state functional magnetic resonance imaging in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared with the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD < controls < DLB), and this was also the case for global efficiency (DLB > controls > AD) and clustering coefficient (DLB < controls < AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences.
authors.affiliation: Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. Electronic address: luis.peraza-rodriguez@newcastle.ac.uk.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Peraza
authors.affiliation: Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: John-Paul
authors.initials: JP
authors.lastname: Taylor
authors.affiliation: Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing Science, Newcastle University, Newcastle upon Tyne, UK; Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.
authors.forename: Marcus
authors.initials: M
authors.lastname: Kaiser
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D015331:Cohort Studies; D063132:Connectome; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020961:Lewy Body Disease / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D009415:Nerve Net / Q000098:blood supply / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: D010100:Oxygen
keywords: Attention impairment; Brain networks; Cognitive fluctuations; Connectome; Resting-state