title: sFlt-1 and IP-10 in women with early-onset preeclampsia.
abstract: Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5pg/mL in preeclamptic women, as compared with 52.28pg/mL in the controls (P=0.0028). The mean serum level of sFlt-1 was 13,636pg/mL in preeclamptic women, as compared with 2020pg/mL in the controls (P<0.0001). PlGF levels were significantly lower in women with preeclampsia.
authors.affiliation: Obstetrics Department, Universidade Federal de São Paulo, Brazil; Laboratory of Immunobiology of Transplantation, Universidade de São Paulo, Brazil; Laboratory of Clinical and Experimental Investigation, Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: De Oliveira
authors.affiliation: Laboratory of Immunobiology of Transplantation, Universidade de São Paulo, Brazil.
authors.forename: Niels Olsen S
authors.initials: NO
authors.lastname: Câmara
authors.affiliation: Obstetrics Department, Universidade Estadual de São Paulo, Botucatu, Brazil.
authors.forename: José C
authors.initials: JC
authors.lastname: Peraçoli
authors.affiliation: Obstetrics Department, Universidade Estadual de São Paulo, Botucatu, Brazil.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Peraçoli
authors.affiliation: Obstetrics Department, Universidade Federal de São Paulo, Brazil.
authors.forename: Antonio F
authors.initials: AF
authors.lastname: Moron
authors.affiliation: Obstetrics Department, Universidade Federal de São Paulo, Brazil; Laboratory of Clinical and Experimental Investigation, Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo, Brazil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Sass