title: A Review of the Toxicologic Implications of Obesity.
abstract: The increasing prevalence of obesity in developed nations has far-reaching implications for medical toxicology. The management of obese patients is complicated by comorbid illnesses, changes in cardiovascular and respiratory physiology, alterations in pharmacokinetics, and a lack of studies to identify appropriate dosing for current therapeutics and antidotes. In this review article, we examine obesity-associated physiologic and pharmacokinetic changes that may increase the vulnerability of obese patients to overdose. Further research is needed to characterize the relationship between drug toxicity and obesity.
authors.affiliation: University of Colorado, Anschutz Medical Campus, 12401 East 17th Avenue, Rm 759, Aurora, CO, 80045, USA, matthew.zuckerman@ucdenver.edu.
authors.forename: Matthew
authors.initials: M
authors.lastname: Zuckerman
authors.forename: Howard A
authors.initials: HA
authors.lastname: Greller
authors.forename: Kavita M
authors.initials: KM
authors.lastname: Babu
mesh_terms: D065567:Absorption, Physiological; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D001711:Biotransformation; D062787:Drug Overdose; D006801:Humans; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D010599:Pharmacokinetics; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism*; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D000931:Antidotes