title: MetabNet: An R Package for Metabolic Association Analysis of High-Resolution Metabolomics Data.
abstract: Liquid-chromatography high-resolution mass spectrometry provides capability to measure >40,000 ions derived from metabolites in biologic samples. This presents challenges to confirm identities of known chemicals and delineate potential metabolic pathway associations of unidentified chemicals. We provide an R package for metabolic network analysis, MetabNet, to perform targeted metabolome-wide association study of specific metabolites to facilitate detection of their related metabolic pathways and network structures.
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
authors.forename: Karan
authors.initials: K
authors.lastname: Uppal
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
authors.forename: Quinlyn A
authors.initials: QA
authors.lastname: Soltow
authors.affiliation: Department of Pathology, University of Washington , Seattle, WA , USA.
authors.forename: Daniel E L
authors.initials: DE
authors.lastname: Promislow
authors.affiliation: New England Primate Research Center, Harvard University , Southborough, MA , USA.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Wachtman
authors.affiliation: Division of Cardiology, Department of Medicine, Emory University , Atlanta, GA , USA.
authors.forename: Arshed Ali
authors.initials: AA
authors.lastname: Quyyumi
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Emory University , Atlanta, GA , USA.
authors.forename: Dean P
authors.initials: DP
authors.lastname: Jones
keywords: choline; metabolic networks; metabolic pathways; metabolite identification; metabolomics; targeted MWAS