title: Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed extract improves obesity and survival of C57BL/6 mice fed a high-fat diet.
abstract: Melinjo (Gnetum gnemon L.) seed extracts (MSEs) are rich in resveratrol dimers (gnemonoside A, C, D, gnetin C), trans-resveratrol, and other resveratrol derivatives. trans-Resveratrol is a widely studied caloric restriction mimetic. In mice fed a high-fat diet (HFD), trans-resveratrol protects against obesity, type 2 diabetes, and premature death. Here, treatment of HFD-fed mice with 2.0% MSE significantly reduced body weight gain (p < 0.001), blood insulin (p < 0.01), and HOMA-IR (p < 0.05) after 8 weeks compared with untreated HFD-fed mice. Additionally, 0.2% MSE treatment of HFD-fed mice significantly improved physiological activity (p < 0.05) at 18 months of age and reduced risk of death due to HFD by 25% (hazard ratio = 0.75, p = 0.036). These data show that MSE can improve several aspects of metabolic syndrome and survival in mice and may have health benefits as a dietary supplement.
authors.affiliation: a Institute for Bee Products and Health Science , Yamada Bee Company, Inc. , 194 Ichiba, Kagamino-cho, Tomata-gun 708-0393 , Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ikuta
authors.affiliation: a Institute for Bee Products and Health Science , Yamada Bee Company, Inc. , 194 Ichiba, Kagamino-cho, Tomata-gun 708-0393 , Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.affiliation: a Institute for Bee Products and Health Science , Yamada Bee Company, Inc. , 194 Ichiba, Kagamino-cho, Tomata-gun 708-0393 , Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tani
authors.affiliation: a Institute for Bee Products and Health Science , Yamada Bee Company, Inc. , 194 Ichiba, Kagamino-cho, Tomata-gun 708-0393 , Japan.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tatefuji
authors.affiliation: a Institute for Bee Products and Health Science , Yamada Bee Company, Inc. , 194 Ichiba, Kagamino-cho, Tomata-gun 708-0393 , Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D035684:Gnetum / Q000737:chemistry*; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000077185:Resveratrol; D012639:Seeds / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry*; D016019:Survival Analysis
chemical_list: D007328:Insulin; D010936:Plant Extracts; D013267:Stilbenes; D000077185:Resveratrol
keywords: high-fat diet-fed mice; longevity; melinjo seed extract; obesity; resveratrol derivatives