title: Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications.
abstract: Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan.
authors.forename: Yueh-Hsia
authors.initials: YH
authors.lastname: Luo
authors.affiliation: National Environmental Health Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan.
authors.forename: Louis W
authors.initials: LW
authors.lastname: Chang
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan ; National Environmental Health Research Center, National Health Research Institutes, 35 Keyan Road, Zhunan 35053, Miaoli County, Taiwan.
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D053768:Metal Nanoparticles / Q000009:adverse effects* / Q000627:therapeutic use; D014018:Tissue Distribution