title: Associations Between Topical Ophthalmic Corticosteroids and Central Serous Chorioretinopathy: A Taiwanese Population-Based Study.
abstract: OBJECTIVE
  To investigate the association between central serous chorioretinopathy (CSCR) and topical ophthalmic corticosteroid use.
  
  
  METHODS
  Data were collected from the Longitudinal Health Insurance Database 2000, containing randomly selected medical claim data from 23 million residents in Taiwan. The study cohort comprised all patients diagnosed with CSCR between January 2001 and December 2010 (n = 2921) with a control group of patients (n = 17,526) matched to study patients according to age, sex, geographic region, and date of index medical care. Demographic characteristics, comorbidities, and corticosteroid use (topical ophthalmic, oral, nasal spray, injected, and inhaled) within 1 year before CSCR diagnosis were examined using univariate logistic regression. Student's t-test was used for continuous variables. Adjusted logistic regression was used to compare the odds ratio (OR) of the prognosis of CSCR patients with that of controls.
  
  
  RESULTS
  In CSCR patients, we observed an increased prevalence of topical ophthalmic corticosteroid use (OR 6.328, 95% confidence interval [CI] 5.786-6.921, P < 0.0001). After adjusting for age, sex, geographic location of the patient's residence, hypertension, diabetes mellitus, hyperlipidemia, chronic renal disease, peptic ulcer, psychiatric disease, allergic respiratory disease, coronary artery disease, and corticosteroid use, conditional logistic regression analysis showed that CSCR patients were more likely to have used topical ophthalmic corticosteroids recently than the controls (OR 6.036, 95% CI 5.512-6.610, P < 0.0001).
  
  
  CONCLUSIONS
  Results strongly support an association between recent topical ophthalmic corticosteroid use and CSCR. Thus, patients who require ophthalmic corticosteroids should be advised of the associated risk of developing CSCR.
authors.affiliation: Department of Ophthalmology, Chi Mei Medical Center, Tainan, Taiwan 2Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
authors.forename: Yuh-Shin
authors.initials: YS
authors.lastname: Chang
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan 4Department of Hospital and Healthcare Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
authors.forename: Shih-Feng
authors.initials: SF
authors.lastname: Weng
authors.affiliation: Department of Education, University of Taipei, Taipei, Taiwan.
authors.forename: Chun
authors.initials: C
authors.lastname: Chang
authors.affiliation: Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan 6Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Jiu-Yao
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Graduate Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan 8Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
authors.forename: Ren-Long
authors.initials: RL
authors.lastname: Jan
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D056833:Central Serous Chorioretinopathy / Q000139:chemically induced* / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009883:Ophthalmic Solutions / Q000009:adverse effects; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D009883:Ophthalmic Solutions