title: Hepatitis C (chronic).
abstract: BACKGROUND
  About 60% to 85% of people infected with hepatitis C virus will go on to develop chronic hepatitis C, which is now believed to affect 3% of the world's population.
  
  
  METHODS
  We conducted a systematic overview and aimed to answer the following clinical questions: What are the effects of interferon-free treatments in treatment-naïve people with chronic hepatitis C infection without cirrhosis? What are the effects of interferon-free treatments in treatment-naïve people with chronic hepatitis C infection with cirrhosis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this review).
  
  
  RESULTS
  After deduplication and removal of conference abstracts, 30 records were screened for inclusion in the review. Appraisal of titles and abstracts led to the exclusion of 11 studies and the further review of 19 full publications. Of the 19 full articles evaluated, two systematic reviews and one RCT were added. We performed a GRADE evaluation for two PICO combinations.
  
  
  CONCLUSIONS
  In this systematic overview, we categorised the efficacy for 12 different intervention/comparison combinations, based on information relating to the effectiveness and safety of sofosbuvir (with or without ribavirin), sofosbuvir (with or without ribavirin) plus ledipasvir, and sofosbuvir (with or without ribavirin) plus simeprevir, all in people with and without cirrhosis.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Vancouver General Hospital, Vancouver, Canada.
authors.forename: Alan Hoi Lun
authors.initials: AH
authors.lastname: Yau
authors.forename: Vladimir
authors.initials: V
authors.lastname: Marquez-Azalgara
authors.forename: Eric M
authors.initials: EM
authors.lastname: Yoshida
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents