title: Eosinophilic esophagitis associated with celiac disease in children.
abstract: BACKGROUND
  Celiac disease (CD) and eosinophilic esophagitis (EoE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics. Recent studies have found higher rates of EoE in patients with CD than in the general population. Our aim was to estimate the incidence of EoE among children who were diagnosed with CD over a 42-month period.
  
  
  METHODS
  The study included patients diagnosed with CD based on endoscopy and histopathological findings between January 2010 and June 2013. Histopathology reports of esophageal biopsies were reviewed to identify all cases of EoE. The patients' presenting symptoms, laboratory evaluations, endoscopic and histopathological findings, treatments, and follow-ups were analysed.
  
  
  RESULTS
  Fifty-six patients with CD were identified, of whom six (10.7%) were diagnosed with both CD and EoE. Four of these patients presented with abdominal pain and diarrhea, two presented with failure to thrive, and three presented with food allergies. Endoscopic and histopathological changes typical of EoE were observed in all six patients. During follow-up, two patients showed significant improvement with the gluten-free diet and a proton-pump inhibitor (PPI). Two patients improved with the elimination diet and two patients were treated with topical corticosteroid therapy. Endoscopic appearance was normal in all children on follow-up endoscopy after treatment. Biopsy samples also showed resolution of the histologic features of EoE in all of the children.
  
  
  CONCLUSIONS
  The incidence of EoE in our cohort of children with CD was 10.7%, which is higher than what has been reported for the general population. In all children undergoing upper gastrointestinal endoscopy for suspected CD, coexistence of EoE should be considered.
authors.affiliation: Department of Pediatrics, St. John Providence Children's Hospital, Detroit, MI, 48236, USA. drrajmohan.d@gmail.com.
authors.forename: Rajmohan
authors.initials: R
authors.lastname: Dharmaraj
authors.affiliation: Department of Biostatistics, St. John Providence Children's Hospital, Detroit, MI, 48236, USA. karen.hagglund@stjohn.org.
authors.forename: Karen
authors.initials: K
authors.lastname: Hagglund
authors.affiliation: Department of Pediatric Gastroenterology, St. John Providence Childern's Hospital, Wayne State University School of Medicine, Detroit, MI, 48236, USA. hernando.lyons@stjohn.org.
authors.forename: Hernando
authors.initials: H
authors.lastname: Lyons
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000150:complications*; D002648:Child; D057765:Eosinophilic Esophagitis / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011446:Prospective Studies