title: An urgent need for experimental animal model of autism in drug development.
abstract: Construct, face and predictive validities are necessary for any disease model. Although rodent models are used to investigate the neurobiology of autism, however, till date there is no such ideal animal model which can fulfill all the above said validities. Available drug therapy to treat autism is very limited and less effective. In this review, we summarize the work done with rodent models of autism and highlight different validities. We found that, very few studies have studied all the validities in a single study and none of the study fulfilled all the validities. We also reviewed the drugs used in the treatment of autism. Here we propose the limitations of available animal models. We also propose the urgent need of additional models to fulfill all the validities and to understand autism in a better way.
authors.affiliation: Department of Pharmacology, PGIMER, Chandigarh, INDIA.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Ruhela
authors.affiliation: Department of Pharmacology, PGIMER, Chandigarh, INDIA.
authors.forename: Ajay
authors.initials: A
authors.lastname: Prakash
authors.affiliation: Department of Pharmacology, PGIMER, Chandigarh, INDIA.
authors.forename: Bikash
authors.initials: B
authors.lastname: Medhi
keywords: Animal model; Autism; Construct validity; Drug therapy; Face validity