title: The effects of ventilation with high density oxygen on the strength of gastrointestinal anastomosis.
abstract: OBJECTIVE
  The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses.
  
  
  METHODS
  Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats and assigned to an oxygen/nitrous oxide mixture with a fraction of inspired oxygen of 30% in groups 1 and 3 and 80% in groups 2 and 4. The measurements of perianastomotic tissue oxygen pressure, bursting pressure, level of hydroxyproline were evaluated and compared in all groups.
  
  
  RESULTS
  The perianastomotic tissue oxygen pressures, bursting pressures and levels of hydroxyproline were identified as significantly high in groups 2 and 4, administered a fraction of inspired oxygen of 80%, compared to groups 1 and 3, administered a fraction of inspired oxygen of 30%.
  
  
  CONCLUSIONS
  Perioperative supplemental oxygen contributes positively to the anastomotic healing.
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Eker
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Genc
authors.affiliation: Department of General Surgery, Ankara Penal Institution Campus State Hospital, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Sevim
authors.affiliation: Ankara University Biotechnology Institute, Ankara, Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Cumaogullari
authors.affiliation: Department of Anesthesiology and Reanimation, Ankara University Medical School, Ankara, Turkey.
authors.forename: Menekse
authors.initials: M
authors.lastname: Ozcelik
authors.affiliation: Department of General Surgery, Ankara University Medical School, Ankara, Turkey.
authors.forename: Akin Firat
authors.initials: AF
authors.lastname: Kocaay
authors.affiliation: Department of General Surgery, Antalya Education and Training Hospital, Antalya, Turkey.
authors.forename: Cemal Özben
authors.initials: CÖ
authors.lastname: Ensari
authors.affiliation: Department of Medical Biochemistry, Gazi University Medical School, Ankara, Turkey.
authors.forename: Ozge Tugce
authors.initials: OT
authors.lastname: Pasaoglu
keywords: Anastomosis; Oxygen; Wistar rats