title: Therapeutic approaches of magnetic nanoparticles for the central nervous system.
abstract: The diseases of the central nervous system (CNS) represent one of the fastest growing areas of concern requiring urgent medical attention. Treatment of CNS ailments is hindered owing to different physiological barriers including the blood-brain barrier (BBB), which limits the accessibility of potential drugs. With the assistance of a nanotechnology-based drug delivery strategy, the problems could be overcome. Recently, magnetic nanoparticles (MNPs) have proven immensely useful as drug carriers for site-specific delivery and as contrast agents owing to their magnetic susceptibility and biocompatibility. By utilizing MNPs, diagnosis and treatment of CNS diseases have progressed by overcoming the hurdles of the BBB. In this review, the therapeutic aspect and the future prospects related to the theranostic approach of MNPs are discussed.
authors.affiliation: Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751023, Odisha, India.
authors.forename: Fahima
authors.initials: F
authors.lastname: Dilnawaz
authors.affiliation: Laboratory of Nanomedicine, Institute of Life Sciences, Nalco Square, Chandrasekharpur, Bhubaneswar 751023, Odisha, India. Electronic address: sanjeebsahoo2005@gmail.com.
authors.forename: Sanjeeb Kumar
authors.initials: SK
authors.lastname: Sahoo
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy*; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D058185:Magnetite Nanoparticles; D036103:Nanotechnology; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D002491:Central Nervous System Agents; D003287:Contrast Media; D004337:Drug Carriers; D058185:Magnetite Nanoparticles