title: THE INFLUENCE OF CARBON MONOXIDE ON THE SECRETION OF MELATONIN BY PINEALOCYTES MEASURED IN VITRO.
abstract: Photoperiod is considered the most important factor entraining the circannual physiological rhythms through changing circadian patterns of melatonin (MEL) secretion from the pineal gland. The pineal gland of mammals does not respond directly to light but is controlled by light via neuronal phototransduction originating in the retina. In accordance with humoral phototransduction hypothesis, the aim of this study was to determine whether an increased concentration of CO, as a carrier of a light signal in pineal cell culture, affects the synthesis of melatonin. This study demonstrates that a commonly used carbon monoxide donor (CORM-2) markedly stimulated melatonin release from pineal cells incubated in vitro in a time-dependent manner, but the mechanism whereby CO modulates MEL release needs to be further explored.
authors.affiliation: Institute of Applied Biotechnology and Basic Sciences, Center of Applied Biotechnology and Basic Sciences, University of Rzeszow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Romerowicz-Misielak
authors.affiliation: Institute of Applied Biotechnology and Basic Sciences, Center of Applied Biotechnology and Basic Sciences, University of Rzeszow, Poland.
authors.forename: O
authors.initials: O
authors.lastname: Kusak
authors.affiliation: Faculty of Mathematics and Natural Sciences, Department of Computer Engineering University of Rzeszow, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Koziorowska
authors.affiliation: The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland.
authors.forename: F
authors.initials: F
authors.lastname: Przekop
authors.affiliation: Institute of Applied Biotechnology and Basic Sciences, Center of Applied Biotechnology and Basic Sciences, University of Rzeszow, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Koziorowski
mesh_terms: D000121:Acetylserotonin O-Methyltransferase / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D047068:Arylalkylamine N-Acetyltransferase / Q000096:biosynthesis / Q000235:genetics; D002248:Carbon Monoxide / Q000494:pharmacology*; D002478:Cells, Cultured; D055537:Light Signal Transduction / Q000502:physiology*; D008550:Melatonin / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009569:Nitric Oxide / Q000502:physiology; D009942:Organometallic Compounds / Q000494:pharmacology; D017440:Photoperiod; D010870:Pineal Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D034421:Sus scrofa; D013552:Swine; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D012333:RNA, Messenger; C447082:tricarbonyldichlororuthenium (II) dimer; D009569:Nitric Oxide; D002248:Carbon Monoxide; D000121:Acetylserotonin O-Methyltransferase; D047068:Arylalkylamine N-Acetyltransferase; D008550:Melatonin