title: [POLYMORPHISM OF GLUTHATIONE-S-TRANSFERASE P1 IN CHILDREN WITH REFLUX-ESOPHAGITIS].
abstract: The distribution of allele and genotype frequencies of genes of xenobiotic detoxication (CYP2E1--PstI, RsaI, DraI; ADH, ALDH, NAT2, GSTP1, GSTM1, GSTT1) was examined in 147 patients with reflux-esophagitis (RE) and 50 conditionally healthy children 12-18 years. The frequency of AA genotype of GSTP1 gene and A allele was significantly higher in patients with RE as compared with healthy children (χ2 = 4.93; P = 0.03 and χ2 = 5.94; P = 0.01 respectively).
authors.forename: S E
authors.initials: SE
authors.lastname: Zagorskiy
authors.forename: S B
authors.initials: SB
authors.lastname: Melnov
authors.forename: E A
authors.initials: EA
authors.lastname: Sinevich
mesh_terms: D000293:Adolescent; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D004942:Esophagitis, Peptic / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D009481:Neurophysins / Q000235:genetics; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000235:genetics; D014667:Vasopressins / Q000235:genetics
chemical_list: D000444:Aldehyde Dehydrogenase; D001191:Arylamine N-Acetyltransferase; D019392:Cytochrome P-450 CYP2E1; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D009481:Neurophysins; D011498:Protein Precursors; D014667:Vasopressins; C438657:AVP protein, human; C478900:NAT2 protein, human; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human