title: Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians.
abstract: Our meta-analysis was designed to obtain the correlation between thrombomodulin (TM) and high-sensitive C-reactive protein (hs-CRP) levels and the development of cerebral infarction (CI). Case-control studies relevant to the role plasma TM levels and serum hs-CRP levels in the development of CI were retrieved both electronically and manually and further screened according to a predetermined inclusion and exclusion criteria. All enrolled studies were analyzed for meta-regression analyses, sensitivity analyses, and assessments of publication bias. Comprehensive Meta-analysis 2.0 software (CMA 2.0) was used for statistical analysis. A total of 359 studies were initially retrieved, and 13 studies were eventually recruited into our meta-analysis with a total of 881 CI patients (plasma TM levels: n = 513; serum hs-CRP levels: n = 368) and 1067 healthy controls. The results of our meta-analysis suggested that plasma TM levels and serum hs-CRP levels in CI patients were significantly higher than those in healthy controls. In conclusion, increased plasma TM levels and serum hs-CRP levels in CI patients were associated with the development of CI in Asians.
authors.affiliation: Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Psychology, Qiqihar Mental Health Center, Qiqihar, 161000, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, The First Hospital of Qiqihar City, Qiqihar, 161000, China.
authors.forename: Jian-Qi
authors.initials: JQ
authors.lastname: Xiao
authors.affiliation: Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar, 161000, China.
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wei
authors.affiliation: Department of Neurology, Shanghai Houkou District Jiangwan Hospital, Shanghai, China. hanyan.2006@aliyun.com.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Liu
authors.affiliation: Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. lizezhi1981@aliyun.com.
authors.forename: Ze-Zhi
authors.initials: ZZ
authors.lastname: Li
mesh_terms: D044466:Asian People; D002097:C-Reactive Protein / Q000378:metabolism*; D002544:Cerebral Infarction / Q000097:blood*; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D008297:Male; D017594:Publication Bias; D012044:Regression Analysis; D018180:Thrombomodulin / Q000097:blood*
chemical_list: C546931:THBD protein, human; D018180:Thrombomodulin; D002097:C-Reactive Protein
keywords: Cerebral infarction; High-sensitive C-reactive protein; Meta-analysis; Thrombomodulin