title: Sensorineural hearing loss following induction chemotherapy plus concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To compare the incidence of sensorineural hearing loss between those treated with docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by carboplatin concurrent chemoradiotherapy and those treated with conventional concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma.
  
  
  METHODS
  Serial pure tone audiometry was conducted in 36 nasopharyngeal carcinoma patients who were randomised into 2 groups. The first group received docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by carboplatin concurrent chemoradiotherapy. The second group received conventional concurrent chemoradiotherapy.
  
  
  RESULTS
  The incidence of sensorineural hearing loss at speech frequency in the first group was 10 per cent and in the second group was 50 per cent (p = 0.0027). Bone conduction thresholds were significantly increased after completion of the treatment at 2-4 kHz in the first group and at all frequencies in the second group.
  
  
  CONCLUSIONS
  The docetaxel, cisplatin and 5-fluorouracil induction chemotherapy regimen followed by concurrent chemoradiotherapy was associated with a lower incidence of sensorineural hearing loss than conventional concurrent chemoradiotherapy. This regimen may be the preferred choice of treatment for hearing preservation.
authors.affiliation: Department of Otolaryngology,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand.
authors.forename: V
authors.initials: V
authors.lastname: Atchariyasathian
authors.affiliation: Department of Otolaryngology,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Pruegsanusak
authors.affiliation: Department of Otolaryngology,Faculty of Medicine,Prince of Songkla University,Songkhla,Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Wongsriwattanakul
mesh_terms: D000158:Acoustic Impedance Tests; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D059248:Chemoradiotherapy / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D013069:Speech Reception Threshold Test
keywords: Chemoradiotherapy; Nasopharyngeal Carcinoma; Sensorineural Hearing Loss