title: 5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications.
abstract: We report the synthesis, characterization and in vitro release behavior of anti-cancer drug carrying iron oxide@layered double hydroxide core-shell nanocomposites with sizes ranging from 40 to 300 nm, good drug loading capacities and soft ferromagnetic properties. HRTEM analyses verified that nearly spherical isotropic carriers were obtained by coating spherical magnetite particles while anisotropic carriers were obtained by coating spindle-shaped hematite particles. They both displayed a fluctuating in vitro release profile with a higher release percentage for the anisotropic carrier.
authors.affiliation: Hacettepe University, Chemistry Department, Beytepe Campus, 06800 Ankara, Turkey.
authors.forename: Gülsevde
authors.initials: G
authors.lastname: Tuncelli
authors.affiliation: Hacettepe University, Chemistry Department, Beytepe Campus, 06800 Ankara, Turkey. Electronic address: ay@hacettepe.edu.tr.
authors.forename: Ahmet Nedim
authors.initials: AN
authors.lastname: Ay
authors.affiliation: Hacettepe University, Chemistry Department, Beytepe Campus, 06800 Ankara, Turkey. Electronic address: bkaran@hacettepe.edu.tr.
authors.forename: Birgül
authors.initials: B
authors.lastname: Zümreoglu-Karan
mesh_terms: D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D005472:Fluorouracil / Q000737:chemistry*; D006878:Hydroxides / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission
chemical_list: D005290:Ferric Compounds; D006878:Hydroxides; C000499:ferric oxide; D005472:Fluorouracil
keywords: 5-Fluorouracil; Core-shell carriers; Layered double hydroxide; Magnetic drug delivery; Particle morphology