title: [GENETIC ASPECTS OF CHRONIC GLOMERULONEPHRITIS].
abstract: The aim of our work was to determine the the gene polymorphism of IL-1β in children with chronic glomerulonephritis. there has been defined the frequency of combinations of allelic variants of cytokines genes of IL-1β and IL-10 in chronic glomerulonephritis in children and found the connection of allelic polymorphism with the disease course, indices of hemopoiesis and IL-1β in serum. The presence of C/T genotype is associated with increased production of interleukin-1β in serum. Genetic polymorphism of genes of interleukin can be a new marker of progression of chronic kidney disease.
authors.forename: V
authors.initials: V
authors.lastname: Dudnyk
authors.forename: A
authors.initials: A
authors.lastname: Zvenigorodska
authors.forename: G
authors.initials: G
authors.lastname: Guminska
mesh_terms: D000483:Alleles; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002908:Chronic Disease; D018450:Disease Progression; D004921:Erythropoietin / Q000097:blood / Q000235:genetics; D015870:Gene Expression; D005787:Gene Frequency; D005838:Genotype; D005921:Glomerulonephritis / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006410:Hematopoiesis / Q000235:genetics; D006454:Hemoglobins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D053583:Interleukin-1beta / Q000097:blood / Q000235:genetics*; D007501:Iron / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: D015415:Biomarkers; C554270:EPO protein, human; D006454:Hemoglobins; C508609:IL10 protein, human; D053583:Interleukin-1beta; D004921:Erythropoietin; D016753:Interleukin-10; D007501:Iron