title: Histamine receptor signaling in energy homeostasis.
abstract: Histamine modulates several aspects of energy homeostasis. By activating histamine receptors in the hypothalamus the bioamine influences thermoregulation, its circadian rhythm, energy expenditure and feeding. These actions are brought about by activation of different histamine receptors and/or the recruitment of distinct neural pathways. In this review we describe the signaling mechanisms activated by histamine in the hypothalamus, the evidence for its role in modulating energy homeostasis as well as recent advances in the understanding of the cellular and neural network mechanisms involved. This article is part of the Special Issue entitled 'Histamine Receptors'.
authors.affiliation: The Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: tabarean@scripps.edu.
authors.forename: Iustin V
authors.initials: IV
authors.lastname: Tabarean
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D006632:Histamine / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D011968:Receptors, Histamine / Q000378:metabolism*
chemical_list: D011968:Receptors, Histamine; D006632:Histamine
keywords: Energy homeostasis; Feeding; H1 histamine receptor; H1R antagonist; H2 histamine receptor; H3 histamine receptor; Histamine; Hypothalamus; Signaling; Thermoregulation