title: Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy.
abstract: A 64-year-old woman had suffered from painful livedo reticularis for 2 years and was referred to us due to fever, anasarca and paresthesia of the lower limbs. Serum proteinase-3-anti-neutrophil cytoplasmic antibody (ANCA) was positive. Abnormal lymphocytes were found in the cerebrospinal fluid and bone marrow. Skin biopsy revealed large atypical lymphoid cells with CD20 positivity lodged in the small vessels and neutrophilic infiltration into the arterial vascular wall with fibrinoid degeneration. A diagnosis of intravascular large B-cell lymphoma complicated by ANCA-associated vasculitis was made, and rituximab-containing chemotherapy followed by prednisolone was quite effective for both lymphoma and ANCA-associated vasculitis.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Mariko
authors.initials: M
authors.lastname: Tsuda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Motohiko
authors.initials: M
authors.lastname: Ikeda
authors.forename: Shingo
authors.initials: S
authors.lastname: Shimada
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Nomura
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Matsushima
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takahashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Oda
authors.forename: Motoaki
authors.initials: M
authors.lastname: Shiratsuchi
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D000069283:Rituximab / Q000008:administration & dosage; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D011241:Prednisone