title: A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis.
abstract: A new sesquiterpenoid fomeffic acid (1) and a new triterpene lactone fomefficinin (2) were isolated from the fungus Fomes officinalis, together with another six known compounds fomitopsin C (3), dehydrosulfurenic acid (4), dehydroeburiconic acid (5), dehydroeburicoic acid (6), 3-keto-dehydrosulfurenic acid (7), and laricinolic acid (8). The structures and stereochemistry of 1 and 2 were determined by NMR and X-ray diffraction analyses. The sesquiterpenoid and five triterpenes were tested for cytotoxicity against HL-60, Bel-7402, and KB cancer lines in vitro, and they appeared to be modestly active.
authors.affiliation: a Pharmacology Laboratory of Traditional Chinese Medicine, Hebei University of Chinese Medicine , Shijiazhuang 050200 , China.|b Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.affiliation: b Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Jun-Shan
authors.initials: JS
authors.lastname: Yang
mesh_terms: D055453:Coriolaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D018922:HL-60 Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D007810:Lanosterol / Q000031:analogs & derivatives; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007783:Lactones; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D014315:Triterpenes; C547186:dehydroeburicoic acid; C492580:dehydroeburiconic acid; C437376:drimane; C000605470:fomeffic acid; C000605471:fomefficinin; D007810:Lanosterol
keywords: Fomes officinalis; cytotoxicity; sesquiterpenoid; triterpene