title: EXPRESSION AND CLINICAL SIGNIFICANCE OF APOPTOSIS-ASSOCIATED PROTEINS SURVIVIN AND LIVIN IN CONDYLOMA ACUMINATUM.
abstract: The objective of the present study was to explore the expression and significance of survivin and Livin in lesions of Condyloma acuminatum (CA). Streptavidin-peroxidase (SP) immunohistochemistry method was used to measure the expression of survivin, Livin and Ki-67 in 48 cases of CA and 25 cases of normal foreskin tissues. The positive expression rates of survivin, Livin and Ki-67 were 72.91% (35/48), 77.08% (37/48) and 85.42% (41/48) in CA tissues, and 4% (1/25), 4% (5/25) and 60% (15/25) in the control group, respectively. The expression intensity of survivin, Livin and Ki-67 in CA tissues (++ ~ +++) was significantly higher than that in the normal control group (- ~ ++). There were significant differences (P <0.05) both in the positive rates and the expression intensity of survivin, Livin and Ki-67 between the two groups. There was positive correlation between the expression of survivin and Livin in CA group (P < 0.01); the expressions of survivin and Ki-67 were positively correlated with each other (P < 0.01); Livin and Ki-67 expressions were positively correlated with each other (P < 0.01). There were over-expressions and excessive proliferations of survivin and Livin in CA tissues, and apoptosis suppressors survivin and Livin were correlated with CA.
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: G-W
authors.initials: GW
authors.lastname: Yin
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Dermatology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou City, Henan Province, China.
authors.forename: H-B
authors.initials: HB
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics; D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002455:Cell Division; D003218:Condylomata Acuminata / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005832:Genital Diseases, Male / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D051034:Inhibitor of Apoptosis Proteins / Q000096:biosynthesis* / Q000235:genetics; D019394:Ki-67 Antigen / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D000077022:Survivin; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C107489:BIRC5 protein, human; C419866:BIRC7 protein, human; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D000077022:Survivin