title: Association between serum ferritin level and diastolic cardiac function in patients with major β-thalassemia.
abstract: BACKGROUND
  Prevention of myocardial siderosis is a key step to reduce rate of mortality in thalassemic patients. Our objective was to study association between echocardiography parameters and serum ferritin level in patients with major thalassemia.
  
  
  METHODS
  Sixty-six patients with major thalassemia were studied in Amir Kabir hospital, Arak, Iran. Serum ferritin levels were measured during 3 months in patients with no symptoms of infection. It was measured by enzyme-linked immunosorbent assay (ELISA). Ejection Fraction (EF), Fractional Shortening (FS) and Early/Late ratio (E/A) were studied by echocardiography.
  
  
  RESULTS
  Fifty two percent were female and 48% were male. Mean age was 16 ± 9 years and the age range was3-26years. Mean serum ferritin level was1912 ± 1748 ng/dl and its range was from 303 to 8333 ng/dl. There were significant correlations between serum ferritin level and EF(r=0.3 and P=0.05) and also between serum ferritin level and FS.
  
  
  CONCLUSIONS
  Due to significant association between serum ferritin level and echo parameters, it is beneficial that all patients with major thalassemia undergo echocardiography to gain better understating about cardiac function.
authors.affiliation: Pediatric Hematologist & Oncologist, Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Eghbali
authors.affiliation: Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Taherahmadi
authors.affiliation: Cancer Research Center and Department of Pharmacology, Semnan University of Medical sciences, Semnan, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Bagheri
authors.affiliation: Student of Medicine, Arak University of Medical Sciences, Arak, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Nikanjam
authors.affiliation: Blood transfusion research center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
authors.forename: L
authors.initials: L
authors.lastname: Ebrahimi
keywords: Diastolic Dysfunction; Echocardiography; Ejection Fraction; Ferritin; Thalassemia