title: Oxaliplatin for the treatment of ovarian cancer.
abstract: BACKGROUND
  Oxaliplatin is an important drug in treatment of several solid tumors. Ovarian cancer (OC) is sensitive to chemotherapy and the overall response rate with primary therapy is about 75%. Unfortunately, 60 - 70% of patients experience recurrence requiring additional treatments and finally die of progressive disease within 5 years of the initial diagnosis. Currently, a platinum-based combination therapy is recommended in platinum-sensitive disease while a non-platinum single-agent therapy is preferred in platinum-resistant disease that is characterized by a low response rate.
  
  
  METHODS
  In this article, the authors review the Phase II and Phase III studies of oxaliplatin as an OC therapy. Furthermore, the authors discuss the pharmacokinetic and pharmacodynamic features of oxaliplatin.
  
  
  CONCLUSIONS
  Platinum emerged as the mainstay of OC treatment in frontline therapy, and platinum compounds remain a critical component of chemotherapy also in relapsed disease. Unfortunately, increasing exposure to carboplatin/cisplatin raises the risk of resistance or hypersensitivity to platinum. Several studies have demonstrated the safety and effectiveness of oxaliplatin, both alone and in combination regimens, in relapsed OC, demonstrating a good tolerability profile. Moreover, the therapeutic spectrum of oxaliplatin might be extended to OC patients who experienced hypersensitivity to carboplatin because of its favorable toxicity profile and at least equal efficacy.
authors.affiliation: IRCCS-Fondazione Policlinico San Matteo and University of Pavia, Department of Obstetrics and Gynaecology , 19 Viale Camillo Golgi, 27100 Pavia , Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bogliolo
authors.forename: Chiara
authors.initials: C
authors.lastname: Cassani
authors.forename: Barbara
authors.initials: B
authors.lastname: Gardella
authors.forename: Valentina
authors.initials: V
authors.lastname: Musacchi
authors.forename: Luciana
authors.initials: L
authors.lastname: Babilonti
authors.forename: Pier-Luigi
authors.initials: PL
authors.lastname: Venturini
authors.forename: Simone
authors.initials: S
authors.lastname: Ferrero
authors.forename: Arsenio
authors.initials: A
authors.lastname: Spinillo
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000077150:Oxaliplatin
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: adverse effect to platinum; chemotherapy; hypersensitivity to platinum; ovarian cancer therapy; oxaliplatin