title: 807C/T polymorphism of platelet glycoprotein Ia gene is associated with cerebral hemorrhage in a Chinese population.
abstract: Platelet glycoprotein (GP) mediated the role of platelet in coagulation. Platelet GP Ia 807C/T is the only GP polymorphism associated with the expression levels of GP Ia/IIa (the platelet collagen receptor). Recently, the GP Ia 807C/T polymorphism has been reported to have no association with cerebral hemorrhage (CH) in two studies pertained to Caucasian populations. The purpose of this study is to evaluate the association between platelet GP Ia 807C/T polymorphism and CH in a Han Chinese population. We performed genotype analysis for platelet GP Ia 807C/T polymorphism in a case-control study involving 195 patients with CH and 116 age- and sex-matched controls. In contrast to previous reports, we found that the frequencies of GP Ia 807C/T T allele, CT and TT genotype were much higher in CH patients than in controls (33.9% vs. 22.8%, p = 0.004; 45.5% and 11.1% vs. 40.4% and 2.6%, p = 0.022). Logistic regression analysis revealed that the presence of GP Ia 807C/T C allele and CC genotype were both associated with a decreased risk of CH compared with T allele, CT and TT genotypes, respectively (adjusted odds ratio [OR] = 0.565, 95% CI: 0.384-0.887, p = 0.005; adjusted OR = 0.172, 95% CI: 0.043-0.639, p = 0.009; adjusted OR = 0.254, 95% CI: 0.085-0.961, p = 0.041, respectively). These findings indicated that platelet GP Ia 807C/T polymorphism could be a protective factor of CH in the Chinese population.
authors.affiliation: a 1 Department of Geriatrics, Second Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.affiliation: c 3 Department of Neurology, Second Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Hu
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Qidong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Ma
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Baoqiong
authors.initials: B
authors.lastname: Liu
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xia
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Xu
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Liu
authors.affiliation: b 2 Department of Neurology, Xiangya Hospital , Central South University , Changsha , China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D065840:Protective Factors
chemical_list: D039421:Integrin alpha2
keywords: 807C/T polymorphism; Cerebral hemorrhage; Platelet glycoprotein Ia