title: Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension.
abstract: We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P < 0.05) in women but not in men. In the additive model, the TT group showed the greatest reductions in systolic BP (23 ± 10 mmHg) after treatment. The CT group showed greater reductions in systolic BP (21 ± 11 mmHg) compared to the CC group (8 ± 3 mmHg) (P < 0.05). The reductions in systolic BP of the TT and CT/CC groups were 23 ± 10 and 19 ± 10 mmHg, respectively. The reductions in systolic BP of the CC and TT/CT groups were 8 ± 3 and 21 ± 10 mmHg, respectively. After adjustment for confounding factors, quantitative trait analysis with a general linear model showed that the female patients with TT genotype showed greater reductions in systolic blood pressure after 24 weeks of treatment compared to the patients with the C allele (P < 0.05). The apelin -1860T>C genotype may play an important predictive role in the response to losartan in hypertensive women.
authors.affiliation: Geriatric Medicine Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Jia
authors.affiliation: Geriatric Medicine Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, China.
authors.forename: C
authors.initials: C
authors.lastname: Men
authors.affiliation: Geriatric Medicine Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, China.
authors.forename: K-T
authors.initials: KT
authors.lastname: Tang
authors.affiliation: Geriatric Medicine Department, The First Affiliated Hospital with Nanjing Medical University, Nanjing City, Jiangsu Province, China.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Zhan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000073861:Apelin; D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D019808:Losartan / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins; D019808:Losartan