title: Pervasive Computing Technologies to Continuously Assess Alzheimer's Disease Progression and Intervention Efficacy.
abstract: Traditionally, assessment of functional and cognitive status of individuals with dementia occurs in brief clinic visits during which time clinicians extract a snapshot of recent changes in individuals' health. Conventionally, this is done using various clinical assessment tools applied at the point of care and relies on patients' and caregivers' ability to accurately recall daily activity and trends in personal health. These practices suffer from the infrequency and generally short durations of visits. Since 2004, researchers at the Oregon Center for Aging and Technology (ORCATECH) at the Oregon Health and Science University have been working on developing technologies to transform this model. ORCATECH researchers have developed a system of continuous in-home monitoring using pervasive computing technologies that make it possible to more accurately track activities and behaviors and measure relevant intra-individual changes. We have installed a system of strategically placed sensors in over 480 homes and have been collecting data for up to 8 years. Using this continuous in-home monitoring system, ORCATECH researchers have collected data on multiple behaviors such as gait and mobility, sleep and activity patterns, medication adherence, and computer use. Patterns of intra-individual variation detected in each of these areas are used to predict outcomes such as low mood, loneliness, and cognitive function. These methods have the potential to improve the quality of patient health data and in turn patient care especially related to cognitive decline. Furthermore, the continuous real-world nature of the data may improve the efficiency and ecological validity of clinical intervention studies.
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Bayard E
authors.initials: BE
authors.lastname: Lyons
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Biomedical Engineering, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Austin
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Adriana
authors.initials: A
authors.lastname: Seelye
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Biomedical Engineering, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Johanna
authors.initials: J
authors.lastname: Petersen
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Yeargers
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Riley
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Nora
authors.initials: N
authors.lastname: Mattek
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Wild
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Dodge
authors.affiliation: Oregon Center for Aging and Technology, Oregon Health and Science University , Portland, OR , USA ; Department of Neurology, Oregon Health and Science University , Portland, OR , USA ; Department of Biomedical Engineering, Oregon Health and Science University , Portland, OR , USA ; Neurology Service, Portland Veteran Affairs Medical Center , Portland, OR , USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kaye
keywords: aging in place; dementia; gait; in-home monitoring; medication adherence; sleep; smart home; technologies