title: Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment.
abstract: Cervical cancer is the second leading gynecological malignancy threat to the health of women in the world. However, few improvements in the efficacy of treatments of cervical cancer have been reported for the recurrent and metastasis patterns. As an endogenous antitumor agent, pigment epithelium derived factor (PEDF) has attracted wide attention, and its sensitivity to estrogen suggests a special role in female tumors, including cervical cancer. This review aims to summarize recent findings, the role of PEDF in cervical cancer treatment, and enhance the current understanding of the antitumor properties of PEDF such as inhibiting angiogenesis and metastasis, inducing tumor cell apoptosis and differentiation, and modulating cellular immunity against cervical cancer. The production and delivery of PEDF, as well as derived short peptides and their respective receptors will also be discussed.
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu, Daping, Yuzhong District, Chongqing 400042, P.R. China. gjx_tmmu_obgyn@163.com.
authors.forename: J
authors.initials: J
authors.lastname: Guo
mesh_terms: D020533:Angiogenesis Inhibitors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D004195:Disease Models, Animal; D004337:Drug Carriers; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D018014:Gene Transfer Techniques; D006801:Humans; D007157:Immunologic Surveillance / Q000187:drug effects / Q000276:immunology; D058990:Molecular Targeted Therapy; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D015843:Serpins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004337:Drug Carriers; D004967:Estrogens; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor