title: Supplementation with two probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032, reduces fasting triglycerides and enhances apolipoprotein A-V levels in non-diabetic subjects with hypertriglyceridemia.
abstract: OBJECTIVE
  Previous studies have indicated that supplementation with probiotics might improve lipid metabolism. The objective of the study was to evaluate the effect of supplementation with probiotic strains Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032 on triglyceride (TG) and apolipoprotein A-V (apo A-V) levels.
  
  
  METHODS
  A randomized, double-blinded, placebo-controlled study was conducted with 128 non-diabetic subjects with hypertriglyceridemia. Over a 12-week test period, the probiotic group consumed 2 g/day of a powdered supplement containing L. curvatus HY7601 and L. plantarum KY1032, whereas the placebo group consumed a powder lacking probiotics.
  
  
  RESULTS
  After the treatment, the probiotic group showed an 18.3% (P < 0.001) reduction in TGs and increases of 21.1% (P = 0.001) and 15.6% (P < 0.001) in the apo A-V and LDL particle size, respectively. The probiotic group had a significant reduction in TGs (P = 0.040) and increases in the plasma apo A-V (P = 0.003) and LDL particle size (P < 0.001) compared with the placebo group. In the probiotic group, the reduction in the TG levels was negatively correlated with changes in the apo A-V and baseline TGs, regardless of the APOA5 -1131T > C genotype.
  
  
  CONCLUSIONS
  The consumption of two probiotic strains for 12 weeks reduced TGs and increased the apo A-V and LDL particle size in hypertriglyceridemic subjects. This effect was more pronounced in subjects with higher levels of fasting TGs regardless of their APOA5 -1131T > C genotype.
authors.affiliation: Interdisciplinary Course of Science for Aging, Yonsei University, Seoul, Republic of Korea.
authors.forename: Hyeon Yeong
authors.initials: HY
authors.lastname: Ahn
authors.affiliation: Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea.
authors.forename: Minjoo
authors.initials: M
authors.lastname: Kim
authors.affiliation: Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea.
authors.forename: Jey Sook
authors.initials: JS
authors.lastname: Chae
authors.affiliation: Korea Yakult Co., Ltd., Yongin, Gyeonggi, Republic of Korea.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Ahn
authors.affiliation: Korea Yakult Co., Ltd., Yongin, Gyeonggi, Republic of Korea.
authors.forename: Jae-Hun
authors.initials: JH
authors.lastname: Sim
authors.affiliation: Korea Yakult Co., Ltd., Yongin, Gyeonggi, Republic of Korea.
authors.forename: Il-Dong
authors.initials: ID
authors.lastname: Choi
authors.affiliation: Department of Family Practice, National Health Insurance Corporation Ilsan Hospital, Goyang, Republic of Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea; National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Republic of Korea; Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Republic of Korea; Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jhleeb@yonsei.ac.kr.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000886:Anthropometry; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000737:chemistry* / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000737:chemistry; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000382:microbiology / Q000628:therapy*; D007778:Lactobacillus; D048191:Lactiplantibacillus plantarum; D008077:Lipoproteins, LDL / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D019936:Probiotics / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D001786:Blood Glucose; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: Apolipoprotein A–V; Hypertriglyceridemic; LDL particle size; Probiotic; Triglyceride