title: Toxic epidermal necrolysis complicating antibiotic treatment of puerperal endometritis: a case report.
abstract: The aim of the study is to describe a case report of Lyell syndrome (toxic epidermal necrolysis) involving 63% of body surface which has been associated with antibiotic therapy of mild peurperal endometritis in woman 3 weeks postpartum. Lyell syndrome is a severe life-threatening condition developing due to idiosyncrazy (alergic reaction type IV), most commonly after administration of drugs. Incidence quoted in literature is around 1:1-2000000. Illness severity can be assessed using a SCORTEN scoring system, which predicts patient mortality based on seven independent factors. Lyell syndrome is a very rare but potentially lethal complication of antibiotic treatment.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Simetka
authors.forename: Igor
authors.initials: I
authors.lastname: Michalec
authors.forename: Zdenka Nemeckova
authors.initials: ZN
authors.lastname: Crkvenjas
authors.forename: Hana
authors.initials: H
authors.lastname: Klosova
authors.forename: Lenka
authors.initials: L
authors.lastname: Janackova
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Klat
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002053:Burn Units; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D011645:Puerperal Infection / Q000188:drug therapy; D017192:Skin Diseases, Bacterial / Q000517:prevention & control; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous