title: Chinese border disease virus strain JSLS12-01 infects piglets and down-regulates the antibody responses of classical swine fever virus C strain vaccination.
abstract: During 2012 and 2013, several border disease virus (BDV) strains were identified from Chinese goat and sheep herds. At the same time, pigs from the same areas were found to be seropositive to BDV by ELISA, without showing clinical signs (unpublished data). To examine the susceptibility of pigs to the Chinese BDV strains, BDV isolate JSLS12-01, isolated from naturally infected sheep, was used to infect pigs. Antibody responses, viremia, clinical signs and pathological changes of the infected animals were examined. It confirmed that the current BDV strain could infect the domestic pigs, the animals showed viremia during 4 to 14 days post infection (dpi) and sero-conversion from 14dpi; no clinical and pathological changes were observed. In addition, CSFV maternal antibody did not influence BDV infection. Subsequently, pigs were infected with the BDV isolate and vaccinated with Hog cholera lapinized virus (HCLV) 21 days later to determine the effect of BDV infection on antibody induction of CSFV vaccination. The specific CSFV antibody and neutralizing antibody titers of the BDV infected group remained negative after the primary vaccination. Even after the boost vaccination, they were still significantly lower than those of the uninfected groups (p<0.05). These results indicated that BDV infection could down-regulate the antibody responses of CSFV C-strain vaccination. It should be paid attention that BDV prevalence in pig herds and in live vaccines might hamper the vaccination of CSF.
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: jeason0725@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Mao
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: kfliwenliang@163.com.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address: 934519995@qq.com.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: 243044709@qq.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Hao
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: 89700244@qq.com.
authors.forename: Leilei
authors.initials: L
authors.lastname: Yang
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China; College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address: 623824496@qq.com.
authors.forename: Jiawu
authors.initials: J
authors.lastname: Deng
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: 987505468@qq.com.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China. Electronic address: 1138837046@qq.com.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Wei
authors.affiliation: Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: 1776556843@qq.com.
authors.forename: Jieyuan
authors.initials: J
authors.lastname: Jiang
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D058345:Asymptomatic Infections; D001882:Border Disease / Q000276:immunology*; D018083:Border disease virus / Q000302:isolation & purification / Q000502:physiology*; D002681:China; D006692:Classical Swine Fever Virus / Q000276:immunology*; D006041:Goats; D012756:Sheep; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000821:virology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014765:Viral Vaccines
keywords: Antibody response; BDV; CSFV; Infection; Pig