title: Analysis of 17 Y-STR loci haplotype and Y-chromosome haplogroup distribution in five Chinese ethnic groups.
abstract: To investigate genetic diversity in Chinese populations, 706 unrelated male individuals from five ethnic groups (Han, Korean, Hui, Mongolian, and Tibetan, respectively) were analyzed with 17 Y-chromosomal STRs. The haplotype diversity was 0.99985 in the combined data. A total of 675 distinct haplotypes were observed, of which 649 were unique. Y-chromosome haplogroups in the five groups were also predicted with Y-STR haplotypes. Genetic distance between the five studied ethnic groups and other published groups was analyzed by analysis of molecular variance and visualized in a multidimensional scaling plot. In conclusion, the 17 Y-STR loci are highly polymorphic markers in the five groups and hence are very useful in forensic application, population genetics, and human evolution studies.
authors.affiliation: Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Key Laboratory of Forensic Genetics, Guangzhou, P. R. China.|Guangzhou Institute of Criminal Science and Technology, Guangzhou, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Chu-chu
authors.initials: CC
authors.lastname: Zhang
authors.affiliation: Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of Forensic Genetics, Guangzhou, P. R. China.|Guangzhou Institute of Criminal Science and Technology, Guangzhou, P. R. China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Xue-ling
authors.initials: XL
authors.lastname: Ou
authors.affiliation: Department of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Hong-yu
authors.initials: HY
authors.lastname: Sun
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D010802:Phylogeny
keywords: Chinese ethnic group; Genetic distance; Genetic diversity; Haplogroup distribution; Y-chromosomal short tandem repeat