title: Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung.
abstract: The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to single-photon emission computed tomography (SPECT) has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with antineutrophil cytoplasmic antibody-positive vasculitis. Here, we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Chrystalla
authors.initials: C
authors.lastname: Loutsios
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Neda
authors.initials: N
authors.lastname: Farahi
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Simmonds
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Ian
authors.initials: I
authors.lastname: Cullum
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gillett
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Chandra
authors.initials: C
authors.lastname: Solanki
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: Kishor
authors.initials: K
authors.lastname: Solanki
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: John
authors.initials: J
authors.lastname: Buscombe
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Condliffe
authors.affiliation: Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, UK.
authors.forename: A Mike
authors.initials: AM
authors.lastname: Peters
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
authors.forename: Edwin R
authors.initials: ER
authors.lastname: Chilvers
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D004804:Eosinophils; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium
keywords: Eosinophil Biology; Imaging/CT MRI etc; Pulmonary eosinophilia