title: The NLRP3 inflammasome and stroke.
abstract: Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke.
authors.affiliation: Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China ; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China.
authors.forename: Yeqing
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Xiangyang Hospital of Traditional Chinese Medical Hospital Xiangyang 441021, P. R. China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Ding
authors.affiliation: Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China.
authors.forename: Fa-Xian
authors.initials: FX
authors.lastname: Zhan
authors.affiliation: Wuhan Center for Disease Control and Prevention Wuhan, 430015, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Cai
authors.affiliation: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China.
authors.forename: Xiaoxv
authors.initials: X
authors.lastname: Yin
authors.affiliation: Queens University Belfast Northern Ireland, United Kingdom.
authors.forename: Jin-Lian
authors.initials: JL
authors.lastname: Ling
authors.affiliation: Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Ye
authors.affiliation: Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China.
authors.forename: Shuang-Yi
authors.initials: SY
authors.lastname: Hou
authors.affiliation: School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China.
authors.forename: Zuxun
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Neurology, Shenzhen NO. 2 People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518035, P. R. China.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China.
authors.forename: Jia-Fa
authors.initials: JF
authors.lastname: Liu
keywords: NLRP3; inflammasome; inflammation; stroke