title: [Bone and Nutrition. The relationship between iron and phosphate metabolism].
abstract: Fibroblast growth factor 23 (FGF23) is an essential hormone for phosphate metabolism. It has been shown that intravenous administration of some iron formulations including saccharated ferric oxide induces hypophosphatemic osteomalacia with high FGF23 levels. On the other hand, iron deficiency promotes FGF23 and induces hypophosphatemia in patients with autosomal dominant hypophosphatemic rickets (ADHR). While iron and phosphate metabolism is connected, the detailed mechanism of this connection remains to be clarified.
authors.affiliation: Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takashi
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukumoto
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000378:metabolism; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects; D000077605:Ferric Oxide, Saccharated; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000502:physiology; D005937:Glucaric Acid / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced / Q000378:metabolism; D007275:Injections, Intravenous; D007501:Iron / Q000378:metabolism*; D010018:Osteomalacia / Q000139:chemically induced / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism; D063730:Rickets, Hypophosphatemic / Q000209:etiology / Q000378:metabolism
chemical_list: C000717427:FGF23 protein, human; D005290:Ferric Compounds; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D007501:Iron; D000077605:Ferric Oxide, Saccharated; D005937:Glucaric Acid