title: Synthesis, characterization and applications of N-quaternized chitosan/poly(vinyl alcohol) hydrogels.
abstract: Hydrogels composed of N-quaternized chitosan (NQC) and poly(vinyl alcohol) (PVA) in different weight ratios (1:3), (1:1) and (3:1) chemically crosslinked by glutaraldehyde in different weight ratios – 1.0 and 5.0% – have been prepared. The prepared hydrogels were characterized via several analysis tools such as: Fourier transform IR (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and thermogravimetric analysis (TGA). Different applications have been done on NQC/PVA hydrogels including; metal ions uptake, swellability in different buffer solutions (pH: 4, 7 and 9), swellability and degradation studies in simulated body fluid (SBF) solutions and antimicrobial activity towards bacteria and fungi. The results indicated that crosslinked NQC/PVA hydrogels with glutaraldehyde (GA) are more thermallystable than non crosslinked hydrogels, NQC/PVA hydrogels swell highly in different buffer solutions as PVA content increases and the antimicrobial activity of NQC/PVA hydrogels is higher than NQC itself.
authors.affiliation: Cairo University-Faculty of Science-Chemistry Department, Giza, Egypt. Electronic address: rihamrashad@hotmail.com.
authors.forename: Riham R
authors.initials: RR
authors.lastname: Mohamed
authors.affiliation: Cairo University-Faculty of Science-Chemistry Department, Giza, Egypt.
authors.forename: Mahmoud H
authors.initials: MH
authors.lastname: Abu Elella
authors.affiliation: Cairo University-Faculty of Science-Chemistry Department, Giza, Egypt.
authors.forename: Magdy W
authors.initials: MW
authors.lastname: Sabaa
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002104:Cadmium / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D005848:Geotrichum / Q000187:drug effects; D005976:Glutaral / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D020100:Hydrogels; D000644:Quaternary Ammonium Compounds; D002104:Cadmium; D003035:Cobalt; D000431:Ethanol; D003300:Copper; D009532:Nickel; D011142:Polyvinyl Alcohol; D048271:Chitosan; D005976:Glutaral
keywords: Crosslinked; Hydrogel; Metal ions uptake; Simulated body fluid; Swellability