title: Oxytocin and bone status in men: analysis of the MINOS cohort.
abstract: Oxytocin, a neurohypophysial hormone, regulates bone metabolism in animal studies and postmenopausal women. In men, oxytocin is not associated with bone mineral density, bone turnover markers, or prevalent fractures, but weakly negatively with incident fragility fracture requiring further studies.
  
  
  BACKGROUND
  We previously showed that serum oxytocin (OT) level is associated with bone mineral density (BMD) and bone turnover rate in postmenopausal women. The aim of our study was to assess the relationship between circulating OT levels and bone status in men.
  
  
  METHODS
  In 552 men aged 50 and older from the MINOS cohort, we measured serum levels of OT. We assessed the association of serum OT levels with BMD (lumbar, femoral neck, total hip), bone turnover markers (BTM) (serum N-terminal propeptide of type I procollagen (PINP), bone-specific alkaline phosphatase (bone ALP), and C-terminal telopeptide of type I collagen (CTX-I)) and fracture risk.
  
  
  RESULTS
  In the univariate analysis, serum OT level was not associated with BMD at any site, BTM levels, or with prevalent or incident fracture. OT was significantly correlated with body mass index (BMI) (r = 0.17, p < 0.001), total or bioavalaible 17β-estradiol (r = 0.09, p = 0.04 and r = 0.20, p < 0.001, respectively), free testosterone (r = 0.17, p < 0.001), and leptin (r = 0.16, p < 0.001). Multivariate analysis did not show significant relationship between serum OT and BMD. After adjustment for age, BMI, interaction BMI/age, history of fall in the last year, and BMD, OT and prevalent fracture were not associated. By contrast, the same analysis with additional adjustment for prevalent fracture showed a weakly significant negative association between OT and incident fracture, e.g., after adjustment for femoral neck BMD, HR = 0.73, 95 %CI 0.55-0.99, p = 0.04.
  
  
  CONCLUSIONS
  In men, serum OT levels are not associated with BMD, bone turnover rate, or prevalent fractures. The weak negative relationship with fracture risk requires further studies.
authors.affiliation: Nice University Hospital, Pasteur Hospital, Department of Rheumatology, Nice, F-06003, France. breuil@unice.fr.|UMR E-4320 MATOs CEA/iBEB/SBTN, Université Nice Sophia Antipolis, Faculté de Médecine, Nice, France. breuil@unice.fr.
authors.forename: V
authors.initials: V
authors.lastname: Breuil
authors.affiliation: Nice University Hospital, Cimiez Hospital, Department of Clinical Research, Nice, F-06003, France.
authors.forename: E
authors.initials: E
authors.lastname: Fontas
authors.affiliation: INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Chapurlat
authors.affiliation: Nice University Hospital, Saint Roch Hospital, Department of Hormonology, Nice, F-06003, France.
authors.forename: P
authors.initials: P
authors.lastname: Panaia-Ferrari
authors.affiliation: Nice University Hospital, Saint Roch Hospital, Department of Hormonology, Nice, F-06003, France.|CNRS, iBV UMR 7277, 06100, Nice, France.|Inserm, iBV, U1091, 06100, Nice, France.
authors.forename: H B
authors.initials: HB
authors.lastname: Yahia
authors.affiliation: Nice University Hospital, Saint Roch Hospital, Department of Hormonology, Nice, F-06003, France.
authors.forename: S
authors.initials: S
authors.lastname: Faure
authors.affiliation: Nice University Hospital, Pasteur Hospital, Department of Rheumatology, Nice, F-06003, France.
authors.forename: L
authors.initials: L
authors.lastname: Euller-Ziegler
authors.affiliation: CNRS, iBV UMR 7277, 06100, Nice, France.|Inserm, iBV, U1091, 06100, Nice, France.
authors.forename: E Z
authors.initials: EZ
authors.lastname: Amri
authors.affiliation: INSERM UMR 1033, University of Lyon, Hospices Civils de Lyon, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Szulc
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D015331:Cohort Studies; D005272:Femur Neck / Q000502:physiology; D006621:Hip Joint / Q000502:physiology; D006801:Humans; D008159:Lumbar Vertebrae / Q000502:physiology; D008297:Male; D008875:Middle Aged; D058866:Osteoporotic Fractures / Q000097:blood / Q000503:physiopathology; D010121:Oxytocin / Q000097:blood*
chemical_list: D010121:Oxytocin
keywords: Bone mineral density; Fracture; Human; Male; Osteoporosis; Oxytocin