title: Horses for courses: reaching outside drug-like chemical space for inhibitors of challenging drug targets.
authors.affiliation: Department of Chemistry, Boston University, Boston, MA 02215, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Whitty
authors.affiliation: Department of Chemistry, Boston University, Boston, MA 02215, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
mesh_terms: D001688:Biological Products / Q000737:chemistry* / Q000493:pharmacokinetics; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011485:Protein Binding; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001688:Biological Products; D047028:Macrocyclic Compounds; D010455:Peptides; D004364:Pharmaceutical Preparations; D011506:Proteins
keywords: ADME; covalent inhibitors; druggability; druglikeness; foldamers; macrocycles; protein–protein interactions