title: Biotransformation of (-)-α-pinene and geraniol to α-terpineol and p-menthane-3,8-diol by the white rot fungus, Polyporus brumalis.
abstract: In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after three days. Moreover, another substrate, the acyclic monoterpenoids geraniol was transformed into the cyclic compound, p-menthane-3, 8-diol (PMD). The main metabolites, i.e., α-terpineol and PMD, are known to be bioactive monoterpene alcohol compounds. This study highlights the potential of fungal biocatalysts for monoterpene transformation.
authors.affiliation: Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Su-Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Seon-Hong
authors.initials: SH
authors.lastname: Kim
authors.forename: Chang-Young
authors.initials: CY
authors.lastname: Hong
authors.forename: Se-Yeong
authors.initials: SY
authors.lastname: Park
authors.forename: In-Gyu
authors.initials: IG
authors.lastname: Choi
mesh_terms: D000080462:Acyclic Monoterpenes; D000081008:Bicyclic Monoterpenes; D001711:Biotransformation; D002849:Chromatography, Gas; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000378:metabolism*; D004798:Enzymes / Q000378:metabolism; D013058:Mass Spectrometry; D008610:Menthol / Q000031:analogs & derivatives / Q000378:metabolism; D039821:Monoterpenes / Q000378:metabolism*; D055492:Polyporus / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*
chemical_list: D000080462:Acyclic Monoterpenes; D000081008:Bicyclic Monoterpenes; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D004798:Enzymes; D039821:Monoterpenes; D013729:Terpenes; D008610:Menthol; C016775:alpha-terpineol; C005451:alpha-pinene; C007836:geraniol; C005804:terpin