title: Effects of one resistance exercise session on vascular smooth muscle of hypertensive rats.
abstract: BACKGROUND
  Hypertension is a public health problem and increases the incidence of cardiovascular diseases.
  
  
  OBJECTIVE
  To evaluate the effects of a resistance exercise session on the contractile and relaxing mechanisms of vascular smooth muscle in mesenteric arteries of NG-nitro L-arginine methyl ester (L-NAME)-induced hypertensive rats.
  
  
  METHODS
  Wistar rats were divided into three groups: control (C), hypertensive (H), and exercised hypertensive (EH). Hypertension was induced by administration of 20 mg/kg of L-NAME for 7 days prior to experimental protocols. The resistance exercise protocol consisted of 10 sets of 10 repetitions and intensity of 40% of one repetition maximum. The reactivity of vascular smooth muscle was evaluated by concentration‑response curves to phenylephrine (PHEN), potassium chloride (KCl) and sodium nitroprusside (SNP).
  
  
  RESULTS
  Rats treated with L-NAME showed an increase (p < 0.001) in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) compared to the initial period of induction. No difference in PHEN sensitivity was observed between groups H and EH. Acute resistance exercise reduced (p < 0.001) the contractile response induced by KCl at concentrations of 40 and 60 mM in group EH. Greater (p < 0.01) smooth muscle sensitivity to NPS was observed in group EH as compared to group H.
  
  
  CONCLUSIONS
  One resistance exercise session reduces the contractile response induced by KCl in addition to increasing the sensitivity of smooth muscle to NO in mesenteric arteries of hypertensive rats.
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Tharciano Luiz Teixeira Braga da
authors.initials: TL
authors.lastname: Silva
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Marcelo Mendonça
authors.initials: MM
authors.lastname: Mota
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Milene Tavares
authors.initials: MT
authors.lastname: Fontes
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: João Eliakim Dos Santos
authors.initials: JE
authors.lastname: Araújo
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Vitor
authors.initials: V
authors.lastname: Oliveira Carvalho
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Leonardo Rigoldi
authors.initials: LR
authors.lastname: Bonjardim
authors.affiliation: Universidade Federal de Sergipe, BR.
authors.forename: Márcio Roberto Viana
authors.initials: MR
authors.lastname: Santos
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001835:Body Weight; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017079:Exercise Tolerance / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology*; D008638:Mesenteric Arteries / Q000503:physiopathology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009599:Nitroprusside / Q000032:analysis; D010656:Phenylephrine / Q000032:analysis; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011189:Potassium Chloride / Q000032:analysis; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D009599:Nitroprusside; D010656:Phenylephrine; D011189:Potassium Chloride; D019331:NG-Nitroarginine Methyl Ester