title: Inhibitors of Protein Translocation Across the ER Membrane.
abstract: Protein translocation into the endoplasmic reticulum (ER) constitutes the first step of protein secretion. ER protein import is essential in all eukaryotic cells and is particularly critical in fast-growing tumour cells. Thus, the process can serve as target both for potential cancer drugs and for bacterial virulence factors. Inhibitors of protein transport across the ER membrane range from broad-spectrum to highly substrate-specific and can interfere with virtually any stage of this multistep process, and even with transport of endocytosed antigens into the cytosol for cross-presentation.
authors.affiliation: Institute of Biology, CSCM, University of Lübeck, Lübeck, Germany.
authors.forename: Kai-Uwe
authors.initials: KU
authors.lastname: Kalies
authors.affiliation: Department of Microbiology, Faculty of Natural Sciences and Technology VIII, Saarland University, 66123, Saarbrücken, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Römisch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000187:drug effects* / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D026901:Membrane Transport Proteins
keywords: ER-associated degradation; Sec61 channel; antigen cross-presentation; endoplasmic reticulum; membrane protein integration; protein secretion; protein translocation