title: Perspective on unraveling the versatility of 'co-repressor' complexes.
abstract: A multitude of post-translational modifications take place on histones, one of the best studied being acetylation on lysine residues, which is generally associated with gene activation. During the last decades, several so-called co-repressor protein complexes that carry out the reverse process, histone deacetylation, have been identified and characterized, such as the Sin3, N-CoR/SMRT and NuRD complexes. Although a repressive role for these complexes in regulating gene expression is well established, accumulating evidence also points to a role in gene activation. Here, we argue that integration of various state-of-the-art technologies, addressing different aspects of transcriptional regulation, is essential to unravel this apparent biological versatility of 'co-repressor' complexes.
authors.affiliation: Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands.
authors.forename: H Irem
authors.initials: HI
authors.lastname: Baymaz
authors.affiliation: Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands.
authors.forename: Ino D
authors.initials: ID
authors.lastname: Karemaker
authors.affiliation: Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands. Electronic address: M.vermeulen@ncmls.ru.nl.
authors.forename: Michiel
authors.initials: M
authors.lastname: Vermeulen
mesh_terms: D000818:Animals; D056970:Co-Repressor Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex / Q000502:physiology; D046912:Multiprotein Complexes / Q000502:physiology*; D056971:Nuclear Receptor Co-Repressor 1 / Q000502:physiology; D056985:Nuclear Receptor Co-Repressor 2 / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D056970:Co-Repressor Proteins; D046912:Multiprotein Complexes; C539127:NCOR1 protein, human; D056971:Nuclear Receptor Co-Repressor 1; D056985:Nuclear Receptor Co-Repressor 2; D014157:Transcription Factors; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex
keywords: Co-repressor complexes; Gene regulation; Histone deacetylation; Technology integration