title: Oral application of lactic acid bacteria following treatment with antibiotics inhibits allergic airway inflammation.
abstract: OBJECTIVE
  To investigate whether lactic acid bacteria (LAB) can exhibit anti-allergy properties in antibiotics-treated mice model.
  
  
  RESULTS
  Antibiotic treatment affected the composition of the intestinal microbiota and its metabolites, and thus has a mild effect on Th1/Th2 balance. Oral administration of Streptococcus thermophilus CCFM218 (ST218) could not fully repair antibiotic-induced damage to the intestinal microbiota and its metabolites, and restore them to their original condition. But ST218 treatment revealed a strong suppressive effect on airway inflammation characterized by reduced inflammatory cell infiltration and levels of Th2 cytokines in lung tissues, which was associated with an enhanced mucosal tolerance.
  
  
  CONCLUSIONS
  These results showed that ST218 could alleviate allergic responses in mice treated with antibiotics, primarily through the modulation of mucosal and systemic responses rather than the restoration of the intestinal microbiota.
  
  
  CONCLUSIONS
  The rise in incidence in allergies may correlate with the widespread and liberal use of antibiotics. This study affirmed that one species of LAB ST218 significantly reduces allergic airway inflammation in antibiotic-treated mice model.
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: C
authors.initials: C
authors.lastname: Ai
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: F
authors.initials: F
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.|Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing 100048, China.
authors.forename: W
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D019344:Lactic Acid / Q000378:metabolism; D008168:Lung / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D019936:Probiotics / Q000008:administration & dosage*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000276:immunology; D048249:Streptococcus thermophilus / Q000502:physiology*; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D016207:Cytokines; D019344:Lactic Acid
keywords: allergy; antibiotics; inflammation; intestinal microbiota; lactic acid bacteria