title: Evolution of antimicrobial resistance and serotype distribution of Streptococcus pneumoniae isolated from children with invasive and noninvasive pneumococcal diseases in Algeria from 2005 to 2012.
abstract: Pneumococcal infections are a major cause of morbidity and mortality in developing countries. The introduction of pneumococcal conjugate vaccines (PCVs) has dramatically reduced the incidence of pneumococcal diseases. PCVs are not currently being used in Algeria. We conducted a prospective study from 2005 to 2012 in Algeria to determine antimicrobial drug resistance and serotype distribution of Streptococcus pneumoniae from children with pneumococcal disease. Among 270 isolated strains from children, 97 (36%) were invasive disease; of these, 48% were not susceptible to penicillin and 53% not susceptible to erythromycin. A high rate of antimicrobial nonsusceptibility was observed in strains isolated from children with meningitis. The serotype distribution from pneumococci isolated from children with invasive infections was (by order of prevalence): 14, 1, 19F, 19A, 6B, 5, 3, 6A and 23F. Multidrug resistance was observed in serotypes 14, 19F, 19A and 6B. The vaccine coverage of serotypes isolated from children aged <5 years was 55.3% for PCV7, 71.1% for PCV10 and 86.8% for PCV13. Our results highlight the burden of pneumococcal disease in Algeria and the increasing S. pneumoniae antibiotic resistance. The current pneumococcal vaccines cover a high percentage of the circulating strains. Therefore, vaccination would reduce the incidence of pneumococcal disease in Algeria.
authors.affiliation: Service de Microbiologie, Centre Hospitalier Universitaire Mustapha Bacha, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Ramdani-Bouguessa
authors.affiliation: Service de Microbiologie, Centre Hospitalier Universitaire Mustapha Bacha, Algeria.
authors.forename: H
authors.initials: H
authors.lastname: Ziane
authors.affiliation: Centre Hospitalier Universitaire d'Oran, Oran, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Bekhoucha
authors.affiliation: Centre Hospitalier Universitaire Nafissa Hamoud, Algeria.
authors.forename: Z
authors.initials: Z
authors.lastname: Guechi
authors.affiliation: Centre Hospitalier Universitaire Nedir Mohamed, Tizi Ouzou, Algeria.
authors.forename: A
authors.initials: A
authors.lastname: Azzam
authors.affiliation: Centre Hospitalier Universitaire Issad Hassani, Béni-Messous, Algiers, Algeria.
authors.forename: D
authors.initials: D
authors.lastname: Touati
authors.affiliation: Hôpital Central de l'Armée Mohamed Seghir Nekkache, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Naim
authors.affiliation: Hôpital de Boufarik, Blida, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Azrou
authors.affiliation: Hôpital Salim Zmirli, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Hamidi
authors.affiliation: Service de Microbiologie, Centre Hospitalier Universitaire Mustapha Bacha, Algeria.
authors.forename: A
authors.initials: A
authors.lastname: Mertani
authors.affiliation: Centre Hospitalier Universitaire Lamine Debaghine, Algeria.
authors.forename: A
authors.initials: A
authors.lastname: Laraba
authors.affiliation: Centre Hospitalier Universitaire Lamine Debaghine, Algeria.
authors.forename: T
authors.initials: T
authors.lastname: Annane
authors.affiliation: Hopital Ain Taya, Algiers, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Kermani
authors.affiliation: Service de Microbiologie, Centre Hospitalier Universitaire Mustapha Bacha, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Tazir
keywords: Algeria; Streptococcus pneumoniae; antibiotics; burden of disease; children; pneumococcal conjugate vaccines; pneumococcal diseases; serotype distribution