title: Platelet to Lymphocyte Ratio as a Prognostic Marker of In-Hospital and Long-Term Major Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction.
abstract: We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) on in-hospital and long-term major adverse cardiovascular events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) in a large prospective study. Patients (n = 1938) admitted with acute STEMI within 12 hours of symptom onset and who underwent pPCI between January 2010 and January 2015 were followed up for 31.6 ± 16.2 months. During the in-hospital and long-term follow-up period, MACE, the prevalence of stent thrombosis, nonfatal myocardial infarction, and mortality were higher in the third PLR tertile group. A PLR in the third tertile had 2.4-fold increased risk of in-hospital MACE and 2.8-fold risk of long-term MACE. The PLR was significantly and positively correlated with peak creatine kinase MB (CK-MB) levels (r = 0.562, P < .001) and Gensini score (r = 0.408, P < .001). Kaplan-Meier analysis of long-term MACE-free survival revealed a higher occurrence of MACE in the third PLR tertile group compared to the other tertiles. In conclusion, the PLR may be a marker of inflammatory and prothrombotic status and predicted in-hospital and long-term MACE in a population with STEMI.
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey dr.elifhande@gmail.com.
authors.forename: Elif Hande
authors.initials: EH
authors.lastname: Ozcan Cetin
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet Serkan
authors.initials: MS
authors.lastname: Cetin
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Dursun
authors.initials: D
authors.lastname: Aras
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Topaloglu
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temizhan
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Halil Lutfi
authors.initials: HL
authors.lastname: Kisacik
authors.affiliation: Cardiology Department, Türkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydogdu
mesh_terms: D000368:Aged; D056988:Anterior Wall Myocardial Infarction / Q000175:diagnosis / Q000601:surgery*; D001792:Blood Platelets / Q000166:cytology*; D017023:Coronary Angiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Gensini; MACE; ST-segment elevation myocardial infarction; platelet to lymphocyte ratio; thrombosis