title: NLRP3 Inflammasome Activation by Viroporins of Animal Viruses.
abstract: Viroporins are a group of low-molecular-weight proteins containing about 50-120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly, as well as viral particle entry and release. Viroporins also play an important role in the regulation of antiviral innate immune responses, especially in inflammasome formation and activation, to ensure the completion of the viral life cycle. By reviewing the research progress made in recent years on the regulation of the NLRP3 inflammasome by viroporins of animal viruses, we aim to understand the importance of viroporins in viral infection and to provide a reference for further research and development of novel antiviral drugs.
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. gguohuichen@caas.cn.
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. jinye@caas.cn.
authors.forename: Ye
authors.initials: Y
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. zhixiaoyin333@163.com.
authors.forename: Xiao-Yin
authors.initials: XY
authors.lastname: Zhi
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. danyan9005@163.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. sunshiqi@caas.cn.
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Sun
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D014764:Viral Proteins
keywords: NLRP3; animal virus; inflammasome; viroporin