title: Biological mechanism of shockwave in bone.
abstract: Shockwave is a rapid, short duration acoustic wave that carries energy and can propagate through tissue medium. This kind of physical force can be a mechanical stimulus that induces biological effects in living tissue. Extracorporeal shockwave therapy (ESWT) acts as a mechanical stimulus which promotes biological healing processes through a mechanotransduction. The biological effects of ESWT are reported such as tissue regeneration, wound healing, angiogenesis, bone remodeling, and anti-inflammation. Until now, however, little is known about the basic mechanism of action of this type of therapy. This article describes the molecular mechanism on the current status of ESWT with pre-clinical and clinical applications for treating disorders in bone.
authors.affiliation: Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Jai-Hong
authors.initials: JH
authors.lastname: Cheng
authors.affiliation: Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: w281211@adm.cgmh.org.tw.
authors.forename: Ching-Jen
authors.initials: CJ
authors.lastname: Wang
mesh_terms: D001861:Bone Regeneration; D016723:Bone Remodeling; D001842:Bone and Bones / Q000502:physiology*; D005271:Femur Head Necrosis / Q000628:therapy; D019220:High-Energy Shock Waves; D006801:Humans; D040542:Mechanotransduction, Cellular; D018919:Neovascularization, Physiologic; D010003:Osteoarthritis / Q000628:therapy; D014945:Wound Healing / Q000502:physiology
keywords: Biological mechanism; Bone; Shockwave