title: The effect of disease control on mean platelet volume and red blood cell distribution in patients with acromegaly.
abstract: OBJECTIVE
  Several studies have shown increased atherogenic risk factors and biomarkers of inflammation and atherosclerosis in association with growth hormone excess. Mean platelet volume (MPV) and red blood cell distribution (RDW) are currently gaining interest as new independent cardiovascular risk factors. The aim of this study was to evaluate the effect of disease control on MPV and RDW in acromegaly patients.
  
  
  METHODS
  We retrospectively enrolled 36 acromegaly patients (23 males, 13 females; mean age 41.94 ± 11.55). Patients were divided into two groups: disease controlled by surgical treatment alone (group A) or by somatostatin analog (SSA) therapy (group B). MPV and RDW measurements were evaluated during active and inactive disease periods in the two groups.
  
  
  RESULTS
  There were statistically significant increases in MPV and RDW in patients receiving SSA therapy (P = 0.012 and P = 0.020, respectively). The differences in MPV and RDW changes in patients receiving surgical treatment alone were not statistically significant (P=0.364 and P=0.339, respectively).
  
  
  CONCLUSIONS
  This is the first report on the evaluated the effect of disease control on MPV and RDW in acromegaly patients. Our study results showed that MPV and RDW measurements are significantly increased in acromegaly patients with disease controlled by SSA therapy. Therefore, acromegalic patients treated with SSAs may have increased cardiovascular risk based on an increase in MPV and RDW.
authors.affiliation: Department of Endocrinology and Metabolism, Medical Faculty, Yuzuncu Yil University Van, Turkey.
authors.forename: Rifki
authors.initials: R
authors.lastname: Ucler
authors.affiliation: Department of Internal Medicine, Medical Faculty, Yuzuncu Yil University Van, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.affiliation: Department of Endocrinology and Metabolism, Medical Faculty, Yuzuncu Yil University Van, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Atmaca
authors.affiliation: Department of Endocrinology and Metabolism, Medical Faculty, Yuzuncu Yil University Van, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Alay
authors.affiliation: Department of Endocrinology and Metabolism, Bitlis State Hospital Bitlis, Turkey.
authors.forename: Esra Nur
authors.initials: EN
authors.lastname: Ademoglu
authors.affiliation: Department of Endocrinology and Metabolism, Van Education and Research Hospital Van, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Candan
authors.affiliation: Department of Neurosurgery, Medical Faculty, Yuzuncu Yil University Van, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Gulsen
keywords: Acromegaly; cardiovascular risk; inflammation; somatostatin