title: TB vaccines; promoting rapid and durable protection in the lung.
abstract: TB vaccine discovery has focused on IFN-γ both for the selection of antigens and vaccine delivery strategies. Recent breakthroughs in our understanding of the requirements for immunological memory and the expression of immunity to TB in the lung now provide a framework for reconsidering that strategy. We will discuss the status of the TB vaccine field, recent insights into the role of central memory cells and the potential of tissue-resident memory cells in vaccine promoted protection against TB.
authors.affiliation: Statens Serum Institut, Infectious Disease Immunology, 5 Artillerivej, DK-2300 Copenhagen S, Denmark. Electronic address: pa@ssi.dk.
authors.forename: Peter
authors.initials: P
authors.lastname: Andersen
authors.affiliation: Center for Infectious Disease Research (Formerly Seattle Biomedical Research Institute), Seattle, WA 98109, USA; Department of Immunology, University of Washington, Seattle, WA 98109, USA.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Urdahl
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000378:metabolism; D008168:Lung / Q000276:immunology* / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology / Q000637:transplantation; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control*; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines; D007371:Interferon-gamma