title: Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders.
abstract: Clinically, the therapeutic outcomes in neurodegenerative disorders (NDs) by drug treatment are very limited, and the most insurmountable obstacle in the treatment of NDs is the blood-brain barrier (BBB), which provides the highest level of protection from xenobiotics. A great deal of attention still needs to be paid to overcome these barriers, and surface-engineered polymeric nanoparticles are emerging as innovative tools that are able to interact with the biological system at a molecular level for the desired response. The present review covers the potential importance of surface-structure-engineered nanoparticles to overcome the BBB for good bioavailability, and the evaluation of drug therapy in NDs.
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Devendra
authors.initials: D
authors.lastname: Singh
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Himani
authors.initials: H
authors.lastname: Kapahi
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Muzamil
authors.initials: M
authors.lastname: Rashid
authors.affiliation: b Department of Pharmacology , I.S.F. College of Pharmacy , Moga, Punjab , India.|c Brain Research Laboratory, Department of Pharmacology , Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) , 42300, Puncak Alam, Malaysia.
authors.forename: Atish
authors.initials: A
authors.lastname: Prakash
authors.affiliation: c Brain Research Laboratory, Department of Pharmacology , Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) , 42300, Puncak Alam, Malaysia.
authors.forename: Abu Bakar Abdul
authors.initials: AB
authors.lastname: Majeed
authors.affiliation: a Department of Pharmaceutics , I.S.F. College of Pharmacy , Moga, Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D004337:Drug Carriers / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D053758:Nanoparticles; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D013499:Surface Properties; D015262:Xenobiotics / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D015262:Xenobiotics
keywords: BBB; conjugation; neurodegenerative disorders; surface-modified nanoparticles; transcytosis