title: The helminth parasite proteome at the host-parasite interface - Informing diagnosis and control.
abstract: Helminth parasites are a significant health burden for humans in the developing world and also cause substantial economic losses in livestock production across the world. The combined lack of vaccines for the major human and veterinary helminth parasites in addition to the development of drug resistance to anthelmintics in sheep and cattle mean that controlling helminth infection and pathology remains a challenge. However, recent high throughput technological advances mean that screening for potential drug and vaccine candidates is now easier than in previous decades. A better understanding of the host-parasite interactions occurring during infection and pathology and identifying pathways that can be therapeutically targeted for more effective and 'evolution proof' interventions is now required. This review highlights some of the advances that have been made in understanding the host-parasite interface in helminth infections using studies of the temporal expression of parasite proteins, i.e. the parasite proteome, and discuss areas for potential future research and translation.
authors.affiliation: Institute of Immunology & Infection Research, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK.
authors.forename: Anna M
authors.initials: AM
authors.lastname: van der Ree
authors.affiliation: Institute of Immunology & Infection Research, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, UK. Electronic address: fmutapi@staffmail.ed.ac.uk.
authors.forename: Francisca
authors.initials: F
authors.lastname: Mutapi
mesh_terms: D000818:Animals; D014943:Global Health; D015801:Helminth Proteins / Q000502:physiology*; D006373:Helminthiasis / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D006376:Helminths / Q000502:physiology*; D006790:Host-Parasite Interactions / Q000502:physiology*; D006801:Humans; D020543:Proteome / Q000502:physiology*
chemical_list: D015801:Helminth Proteins; D020543:Proteome
keywords: Host-parasite interface; Immune response; Interaction; Parasitic helminths; Proteomics; Vaccine and drug candidates