title: Hyporeactivity of Alveolar Macrophages and Higher Respiratory Cell Permissivity Characterize DBA/2J Mice Infected by Influenza A Virus.
abstract: Influenza A virus remains a major public health problem. Mouse models have been widely used to study influenza infection in mammals. DBA/2J and C57BL/6J represent extremes in terms of susceptibility to influenza A infection among inbred laboratory mouse strains. Several studies focused specifically on the factors responsible for the susceptibility of DBA/2J or the resistance of C57BL/6J and resulted in impressive lists of candidate genes or factors over- or underexpressed in one of the strains. We adopted a different phenotypical approach to identify the critical steps of the infection process accounting for the differences between DBA/2J and C57BL/6J strains. We concluded that both a dysfunction of alveolar macrophages and an increased permissivity of respiratory cells rendered DBA/2J more susceptible to influenza infection.
authors.affiliation: Department of Veterinary Pathology, University of Liège , Liège, Belgium .
authors.forename: Tomás
authors.initials: T
authors.lastname: Casanova
authors.affiliation: Department of Veterinary Pathology, University of Liège , Liège, Belgium .
authors.forename: Els
authors.initials: E
authors.lastname: Van de Paar
authors.affiliation: Department of Veterinary Pathology, University of Liège , Liège, Belgium .
authors.forename: Daniel
authors.initials: D
authors.lastname: Desmecht
authors.affiliation: Department of Veterinary Pathology, University of Liège , Liège, Belgium .
authors.forename: Mutien-Marie
authors.initials: MM
authors.lastname: Garigliany
mesh_terms: D056809:Alveolar Epithelial Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D000818:Animals; D018925:Chemokines / Q000235:genetics / Q000378:metabolism; D003165:Complement System Proteins / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D060467:Disease Resistance; D004198:Disease Susceptibility; D015870:Gene Expression; D007150:Immunohistochemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology; D009980:Influenza A virus / Q000276:immunology*; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D016676:Macrophages, Alveolar / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D051379:Mice; D008811:Mice, Inbred DBA; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000401:mortality / Q000473:pathology / Q000821:virology; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D019562:Viral Load
chemical_list: D018925:Chemokines; D016207:Cytokines; D003165:Complement System Proteins; D019158:N-Acetylneuraminic Acid