title: A short GC rich DNA derived from microbial origin targets tubulin/microtubules and induces apoptotic death of cancer cells.
abstract: A short GC rich DNA derived from microbial origin interacts with tubulin/microtubules activates p53 over expression and induces apoptotic death of human breast cancer (MCF-7) cells.
authors.affiliation: Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India. sghosh@iicb.res.in.
authors.forename: Batakrishna
authors.initials: B
authors.lastname: Jana
authors.forename: Jayita
authors.initials: J
authors.lastname: Sarkar
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Mondal
authors.forename: Surajit
authors.initials: S
authors.lastname: Barman
authors.forename: Saswat
authors.initials: S
authors.lastname: Mohapatra
authors.forename: Debmalya
authors.initials: D
authors.lastname: Bhunia
authors.forename: Krishnangsu
authors.initials: K
authors.lastname: Pradhan
authors.forename: Abhijit
authors.initials: A
authors.lastname: Saha
authors.forename: Anindyasundar
authors.initials: A
authors.lastname: Adak
authors.forename: Subhajit
authors.initials: S
authors.lastname: Ghosh
authors.forename: Surajit
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001483:Base Sequence; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D014404:Tubulin / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014404:Tubulin; D016159:Tumor Suppressor Protein p53; D004247:DNA