title: [Late-onset lupus in the elderly after 65 years: retrospective study of 18 cases].
abstract: OBJECTIVE
  The aim of our study was to investigate characteristics of late-onset lupus after 65 years compared to younger ones.
  
  
  METHODS
  Patients with lupus revealed after 65 years were investigated in four French hospitals between 1985 and 2013. Patients with 4 ACR criteria or more were included. Clinical and biological characteristics, prognosis, treatment, comorbidities were described retrospectively and compared to the cohort of 1000 lupus patients of Cervera et al.
  
  
  RESULTS
  Eighteen patients were included (14 women and 4 men). The most frequent features were arthritis (13/18), skin involvement (9/18). Hemolytic anemia and thrombosis were more frequently found in elderly lupus (p<0.05). During evolution, only cutaneous involvement were less frequent than in young subjects (p <0.05). Corticosteroids were often used (16/18), but iatrogenic complications were frequent (10/16).
  
  
  CONCLUSIONS
  Diagnosis is difficult because of non-specific clinical features. Treatment needed a rigourous follow-up because of iatrogenic complications.
authors.affiliation: Département de médecine interne et gériatrie, CHU Reims, France.
authors.forename: Abrar-Ahmad
authors.initials: AA
authors.lastname: Zulfiqar
authors.affiliation: Département de médecine interne et gériatrie, CHU Reims, France.
authors.forename: Tommy
authors.initials: T
authors.lastname: Courtel
authors.affiliation: Département de médecine interne et gériatrie, CHU Reims, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Novella
authors.affiliation: Département de médecine interne et gériatrie, CHU Reims, France.
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Pennaforte
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones
keywords: follow-up; hematological complications; late-onset lupus