title: Synthesis of New Styrylquinoline Cellular Dyes, Fluorescent Properties, Cellular Localization and Cytotoxic Behavior.
abstract: New styrylquinoline derivatives with their photophysical constants are described. The synthesis was achieved via Sonogashira coupling using the newly developed heterogeneous nano-Pd/Cu catalyst system, which provides an efficient synthesis of high purity products. The compounds were tested in preliminary fluorescent microscopy studies to in order to identify their preferable cellular localization, which appeared to be in the lipid cellular organelles. The spectroscopic properties of the compounds were measured and theoretical TD-DFT calculations were performed. A biological analysis of the quinolines that were tested consisted of cytotoxicity assays against normal human fibroblasts and colon adenocarcinoma cells. All of the compounds that were studied appeared to be safe and indifferent to cells in a high concentration range. The presented results suggest that the quinoline compounds that were investigated in this study may be valuable structures for development as fluorescent dyes that could have biological applications.
authors.affiliation: A. Chelkowski Institute of Physics, University of Silesia, Uniwersytecka 4, Katowice, 40-007, Poland; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Rams-Baron
authors.affiliation: Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland; Institute of Material Sciences, University of Silesia, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Dulski
authors.affiliation: A. Chelkowski Institute of Physics, University of Silesia, Uniwersytecka 4, Katowice, 40-007, Poland; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Mrozek-Wilczkiewicz
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Korzec
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Wioleta
authors.initials: W
authors.lastname: Cieslik
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Spaczyńska
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Bartczak
authors.affiliation: A. Chelkowski Institute of Physics, University of Silesia, Uniwersytecka 4, Katowice, 40-007, Poland; Silesian Center for Education and Interdisciplinary Research, 75 Pulku Piechoty 1A, Chorzow, 41-500, Poland.
authors.forename: Alicja
authors.initials: A
authors.lastname: Ratuszna
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Polanski
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, Katowice, 40-006, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Musiol
mesh_terms: D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003603:Cytotoxins; D005456:Fluorescent Dyes; D011804:Quinolines; C481600:styrylquinoline