title: The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis.
abstract: OBJECTIVE
  Rheumatoid arthritis is a polygenically controlled systemic autoimmune disease. Rheumatoid vasculitis is an important extra-articular phenotype of rheumatoid arthritis that can result in deep cutaneous ulcers. The objective of this study was to establish a correlation between the frequency of major histocompatibility complex class I/II alleles and killer immunoglobulin-like receptor genotypes in patients with cutaneous rheumatoid vasculitis.
  
  
  METHODS
  Using the Scott & Bacon 1984 criteria to diagnose rheumatoid vasculitis and after excluding any other causes such as diabetes, atherosclerosis, adverse drug reactions, infection, and smoking, patients who met the criteria were selected. All of the selected rheumatoid vasculitis patients presented deep cutaneous ulcers. Identification of the major histocompatibility complex class I/II and killer immunoglobulin-like receptor genotypes was performed by polymerase chain reaction assays of samples collected from the 23 rheumatoid vasculitis patients as well as from 80 controls (40 non-rheumatoid vasculitis RA control patients and 40 healthy volunteers).
  
  
  RESULTS
  An association between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and cutaneous lesions in rheumatoid vasculitis patients and a correlation between the inhibitor KIR2DL3 and the HLA-C*0802 ligand in rheumatoid vasculitis patients were found.
  
  
  CONCLUSIONS
  An association was found between the presence of the HLA-DRB1*1402 and HLA-DRB1*0101 alleles and the development of cutaneous lesions in rheumatoid vasculitis patients. Additionally, the HLA-C*0802 ligand protects these individuals from developing cutaneous lesions.
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Wester Eidi
authors.initials: WE
authors.lastname: Nishimura
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Zoraida
authors.initials: Z
authors.lastname: Sachetto
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Lilian Teresa Lavras
authors.initials: LT
authors.lastname: Costallat
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Michel Alexandre
authors.initials: MA
authors.lastname: Yazbek
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Ana Carolina Santos
authors.initials: AC
authors.lastname: Londe
authors.affiliation: Department of Hematology, University of Campinas (UNICAMP), Campinas/, SP, Brazil.
authors.forename: Edilaine Gildo
authors.initials: EG
authors.lastname: Guariento
authors.affiliation: Department of Hematology, University of Campinas (UNICAMP), Campinas/, SP, Brazil.
authors.forename: Silvia Barbosa Dutra
authors.initials: SB
authors.lastname: Marques
authors.affiliation: Department of Rheumatology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Manoel Barros
authors.initials: MB
authors.lastname: Bertolo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology; D001938:Brazil; D005260:Female; D005434:Flow Cytometry; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D054340:Receptors, KIR / Q000235:genetics*; D054344:Receptors, KIR2DL3 / Q000235:genetics*; D056653:Rheumatoid Vasculitis / Q000235:genetics / Q000276:immunology*; D017445:Skin Diseases, Vascular / Q000235:genetics / Q000276:immunology*; D055815:Young Adult
chemical_list: D015236:HLA-C Antigens; D059811:HLA-DRB1 Chains; C487961:HLA-DRB1*01:01 antigen; C515078:KIR2DL3 protein, human; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3