title: Evaluation of anxiolytic activity of aqueous extract of Coriandrum sativum Linn. in mice: A preliminary experimental study.
abstract: OBJECTIVE
  To evaluate the anxiolytic effect of Coriandrum sativum (CS) aqueous extract in mice. To compare the antianxiety activity of CS against standard drug diazepam (3 mg/kg).
  
  
  METHODS
  After obtaining Institutional Animal Ethics Committee approval, Swiss albino mice (18-25 g) of either sex were randomly divided into five groups of six animals each. Dried powder of CS leaves was boiled with distilled water, cooled, filtered, placed on a hotplate for complete evaporation, finally weighed and stored. The control group, test group, and standard drugs group received saline, CS extract (50, 100, and 200 mg/kg), diazepam (3 mg/kg), respectively, by oral feeding. The antianxiety effect was assessed by elevated plus maze (EPM) in mice.
  
  
  RESULTS
  In EPM, it implied that CS 50 mg/kg (Group III), 100 mg/kg (Group IV), and 200 mg/kg (Group V) significantly (P < 0.001) increases the number of entries in open arms compared to control. The time spent in open arms also increased in all the doses of CS extract significantly.
  
  
  CONCLUSIONS
  The current study demonstrates statistically significant dose-dependent antianxiety activity of CS leaves.
authors.affiliation: Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore.
authors.forename: K
authors.initials: K
authors.lastname: Latha
authors.affiliation: Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore.
authors.forename: B
authors.initials: B
authors.lastname: Rammohan
authors.affiliation: Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore.
authors.forename: B P V
authors.initials: BP
authors.lastname: Sunanda
authors.affiliation: Department of Pharmacology, Karpagam Faculty of Medical Sciences and Research, Coimbatore.
authors.forename: M S Uma
authors.initials: MS
authors.lastname: Maheswari
authors.affiliation: Department of Biochemistry, Saveetha Medical College and Hospital, Faculty of Medicine, Saveetha University, Thandalam, Chennai, Tamil Nadu, India.
authors.forename: Surapaneni Krishna
authors.initials: SK
authors.lastname: Mohan
keywords: Antianxiety effect; Coriandrum sativum; Diazepam; Elevated plus maze