title: First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of Lophotrichus.
abstract: We report an aggressive fungal keratitis caused by a putatively novel species of Lophotrichus in a patient with traumatic injury to the cornea from a dog paw. The organism was isolated from the patient's necrotic cornea, which perforated despite coverage with hourly fortified broad-spectrum topical antibiotic therapy. This report represents the first case of human infection caused by this species.
authors.affiliation: Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Allen O
authors.initials: AO
authors.lastname: Eghrari
authors.affiliation: University of Alberta Microfungus Collection and Herbarium, Edmonton, Alberta, Canada.
authors.forename: Connie
authors.initials: C
authors.lastname: Gibas
authors.affiliation: Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Tonya
authors.initials: T
authors.lastname: Watkins
authors.affiliation: Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Vahedi
authors.affiliation: Microbiology Laboratory, the Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors.forename: Rick
authors.initials: R
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Houle
authors.affiliation: Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Suarez
authors.affiliation: Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Eberhart
authors.affiliation: Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.affiliation: Fungus Testing Laboratory, Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.affiliation: Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ssikder1@jhmi.edu szhang28@jhmi.edu.
authors.forename: Shameema
authors.initials: S
authors.lastname: Sikder
authors.affiliation: Department of Pathology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Microbiology Laboratory, the Johns Hopkins Hospital, Baltimore, Maryland, USA ssikder1@jhmi.edu szhang28@jhmi.edu.
authors.forename: Sean X
authors.initials: SX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001203:Ascomycota / Q000302:isolation & purification*; D065306:Corneal Injuries / Q000150:complications; D003320:Corneal Ulcer / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008828:Microbiological Techniques; D008853:Microscopy; D008875:Middle Aged; D008969:Molecular Sequence Data; D009181:Mycoses / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D017422:Sequence Analysis, DNA
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer