title: Emerging medical informatics with case-based reasoning for aiding clinical decision in multi-agent system.
abstract: This research aims to depict the methodological steps and tools about the combined operation of case-based reasoning (CBR) and multi-agent system (MAS) to expose the ontological application in the field of clinical decision support. The multi-agent architecture works for the consideration of the whole cycle of clinical decision-making adaptable to many medical aspects such as the diagnosis, prognosis, treatment, therapeutic monitoring of gastric cancer. In the multi-agent architecture, the ontological agent type employs the domain knowledge to ease the extraction of similar clinical cases and provide treatment suggestions to patients and physicians. Ontological agent is used for the extension of domain hierarchy and the interpretation of input requests. Case-based reasoning memorizes and restores experience data for solving similar problems, with the help of matching approach and defined interfaces of ontologies. A typical case is developed to illustrate the implementation of the knowledge acquisition and restitution of medical experts.
authors.affiliation: Peking University Shenzhen Graduate School - Institute of Big Data Technologies, School of Electronics and Computer Engineering (SECE), Shenzhen Key Lab for Cloud Computing Technology & Applications, PKU Shenzhen Graduate School, 518055 Shenzhen, PR China; Université Paris Ouest (UMR CNRS 7114) - MoDyCo, 200 avenue de la République, 92000 Nanterre, France. Electronic address: ying.shen@u-paris10.fr.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Université du Havre (UMR CNRS CIRTAI/IDEES 6266), 25 Rue Philippe Lebon, 76086 Le Havre Cedex, France. Electronic address: joel.colloc@univ-lehavre.fr.
authors.forename: Joël
authors.initials: J
authors.lastname: Colloc
authors.affiliation: Université Paris Ouest (UMR CNRS 7114) - MoDyCo, 200 avenue de la République, 92000 Nanterre, France; Université Paris Descartes (EA 4569) - Laboratoire d'éthique médicale et de médecine légale, 45 rue des Saints-Pères, 75006 Paris, France. Electronic address: armelle.jacquet@u-paris10.fr.
authors.forename: Armelle
authors.initials: A
authors.lastname: Jacquet-Andrieu
authors.affiliation: Peking University Shenzhen Graduate School - Institute of Big Data Technologies, School of Electronics and Computer Engineering (SECE), Shenzhen Key Lab for Cloud Computing Technology & Applications, PKU Shenzhen Graduate School, 518055 Shenzhen, PR China. Electronic address: leik@pkusz.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Lei
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D003199:Computer Systems; D003657:Decision Making; D020000:Decision Support Systems, Clinical; D003661:Decision Support Techniques; D003936:Diagnosis, Computer-Assisted; D017143:Fuzzy Logic; D006801:Humans; D008490:Medical Informatics / Q000379:methods*; D015233:Models, Statistical; D011336:Probability; D011340:Problem Solving; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000628:therapy*
keywords: Case-based reasoning; Clinical decision support; Knowledge representation; Multi-agent system; Ontology application