title: Lipid transport and human brain development.
abstract: How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprising solution to an old enigma.
authors.affiliation: Vascular Biology Program, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Betsholtz
mesh_terms: D001692:Biological Transport; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008831:Microcephaly / Q000235:genetics; D027981:Symporters; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C549328:MFSD2A protein, human; D027981:Symporters; D025521:Tumor Suppressor Proteins