title: Antifungal drug resistance pattern of Candida. spp isolated from vaginitis in Ilam-Iran during 2013-2014.
abstract: Vaginal Candidiasis is the most common and important opportunistic fungal infection in women. By increasing use of antifungal drugs in recent years, it has caused drug resistance. This study aims to evaluate antifungal drugs susceptibility of Candida. spp isolated of women with vaginitis from Ilam-Iran during 2013-2014. samples were collected and cultured from 385 women with vaginitis, then Candida.spp was diagnosed by standard method. Antifungal drug susceptibility test for nystatin 100 unit/disk, fluconazole 10µg/disk, itraconazole 10µg/disk, ketoconazole 10µg/disk, amphotericinB 20µg/disk, clotrimazole 10µg/disk, posaconazole 5µg/disk, and voriconazole 1µg/disk were carried out by M44-A method(CLSI). From all culture positive samples, 150 isolates were Candida albicans and 89 isolates were non-albicans. The resistance to fluconazole, itraconazole, ketoconazole, clotrimazole, voriconazole, posaconazole, nystatin and amphotericin B was 76%, 62%, 72%, 55%, 6%, 7%, 1% and 0%. The highest resistance was seen for fluconazole , itraconazole, and the highest susceptible was seen for nystatin and amphotericin B. These results indicate nystatin and amphotericin B can be used as the first line for empirical therapy of vaginal candidiasis in the district.
authors.affiliation: Department pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Jasem
authors.initials: J
authors.lastname: Mohamadi
authors.affiliation: Department of Periodontics, School of Dentistry, Ilam University of Medical sciences, Ilam/ Iran.
authors.forename: Mohamad Reza
authors.initials: MR
authors.lastname: Havasian
authors.affiliation: Department of Periodontics, School of Dentistry, Ilam University of Medical sciences, Ilam/ Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Panahi
authors.affiliation: Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran ; Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam/ Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Pakzad
keywords: Candida albicans; Drug resistance; vaginitis