title: DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.
abstract: Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Chouliaras
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Gunter
authors.initials: G
authors.lastname: Kenis
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.|Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Pieter Jelle
authors.initials: PJ
authors.lastname: Visser
authors.affiliation: Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.affiliation: Aristotle University of Thessaloniki, Memory & Dementia Center, 3rd Department of Neurology, G Papanicolaou General Hospital, Thessaloniki, Greece.
authors.forename: Magda
authors.initials: M
authors.lastname: Tsolaki
authors.affiliation: The Research Institute for the Care of Older People (RICE), Bath, UK.
authors.forename: Roy W
authors.initials: RW
authors.lastname: Jones
authors.affiliation: School of Clinical Sciences, Dementia Research Group, University of Bristol Frenchay Hospital, Bristol, UK.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Kehoe
authors.affiliation: Department of Neurobiology, Care Sciences & Society, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Graff
authors.affiliation: Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Italy.
authors.forename: Nicola G
authors.initials: NG
authors.lastname: Girtler
authors.affiliation: Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Sweden.
authors.forename: Åsa K
authors.initials: ÅK
authors.lastname: Wallin
authors.affiliation: Radboud Alzheimer Center, Department of Geriatrics, Donders Institute for Cognitive Neurosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Marcel Olde
authors.initials: MO
authors.lastname: Rikkert
authors.affiliation: "Carol Davila" University of Medicine & Pharmacy, Bucharest, Romania.
authors.forename: Luiza
authors.initials: L
authors.lastname: Spiru
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Lyzel S
authors.initials: LS
authors.lastname: Elias-Sonnenschein
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Inez H G B
authors.initials: IH
authors.lastname: Ramakers
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Pishva
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Harry W M
authors.initials: HW
authors.lastname: Steinbusch
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Frans R J
authors.initials: FR
authors.lastname: Verhey
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Daniel L A
authors.initials: DL
authors.lastname: van den Hove
authors.affiliation: Department of Psychiatry & Neuropsychology, School for Mental Health & Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.|Department of Psychiatry & Psychology, Faculty of Health, Medicine & Life Sciences, School for Mental Health & Neuroscience (MHeNS), European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, PO Box 616 6200 MD, Maastricht, The Netherlands.
authors.forename: Bart P F
authors.initials: BP
authors.lastname: Rutten
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003071:Cognition; D060825:Cognitive Dysfunction / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A
keywords: DNA methylation; DNMT3A; MCI; SNP; aging; epigenetics; mild cognitive impairment