title: Inhibitory Effects of Lanthanum Chloride on Wear Particle-Induced Osteolysis in a Mouse Calvarial Model.
abstract: Osteolysis is a bone disorder associated with progressive destruction of bone tissues. However, the effects of lanthanum chloride (LaCl3) on osteolysis remain unknown. Therefore, the aim of this study was to determine the effects of LaCl3 on osteolysis in vivo. In a mouse calvarial model, C57BL/6J mice were injected with wear particles with or without LaCl3. Microcomputed tomography, hematoxylin and eosin staining, and tartrate-resistant acid phosphatase staining were performed for the pathological characterization of calvariae, and eight calvariae per group were prepared for the assay of TNF-α, IL-1β, and RANKL secretion using quantitative enzyme-linked immunosorbent assay (ELISA). In mice treated with high-dose LaCl3, particle-induced osteolysis and inflammatory reaction were reduced compared with that in the vehicle-treated control. Moreover, treatment with high-dose LaCl3 suppressed the wear particle-induced decrease in bone mineral content, bone mineral density, and bone volume fraction. Bone destruction and resorption were higher in the LaCl3-treated group than in the saline-treated group but lower than those in the wear particle group. Finally, our results showed that treatment with a high dose of LaCl3 suppressed osteoclastogenesis. Thus, LaCl3 may represent a novel therapeutic agent for the treatment or prevention of wear particle-induced osteolysis and aseptic loosening.
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Jiang-Yin-Zi
authors.initials: JY
authors.lastname: Shang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhan
authors.affiliation: Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shangai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Jiang
authors.affiliation: The Chinese People's Liberation Army 94th Hospital, Nanchang, Jiangxi, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Hucheng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China. daimin@medmail.com.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Dai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D004195:Disease Models, Animal; D006622:Hip Prosthesis; D007811:Lanthanum / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008670:Metals / Q000737:chemistry / Q000633:toxicity; D008810:Mice, Inbred C57BL; D010014:Osteolysis / Q000139:chemically induced / Q000517:prevention & control*; D010316:Particle Size; D012886:Skull / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D008670:Metals; C028521:lanthanum chloride; D007811:Lanthanum
keywords: Calvarial model; Lanthanum chloride; Osteoclastogenesis; Osteolysis; Wear particle