title: Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.
abstract: RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malignancies. Let-7, one of the most well-known tumor suppressors, is frequently down-regulated in a variety of human cancers. The RBP LIN28A/LIN28B, a direct target of the let-7 family of miRNAs, is an inhibitor of let-7 biogenesis and is frequently up-regulated in cancers. Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors is reportedly involved in cancer development, contributing to cellular proliferation, cell death resistance, angiogenesis, metastasis, metabolism reprogramming, tumor-associated inflammation, genome instability, acquiring immortality and evading immune destruction. In this review, we summarized the mechanisms of LIN28A/LIN28B and let-7 loop aberrant regulation in human cancer and discussed the roles and potential mechanisms of the LIN28A/LIN28B and let-7 loop in regulating the hallmarks of cancer. The crosstalk between LIN28A/LIN28B and let-7 loop and certain oncogenes (such as MYC, RAS, PI3K/AKT, NF-κB and β-catenin) in regulating hallmarks of cancer has also been discussed.
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China. wtzpath@163.com.
authors.forename: Tianzhen
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. wangguangyu03@163.com.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.affiliation: Faculty of Health Sciences, University of Macau, Taipa, Macau, China. yb47615@umac.mo.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Hao
authors.affiliation: Center of Cardiovascular, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, China. 13836117714@163.com.
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. wangdong@ems.hrbmu.edu.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, International Hospital of Pecking University, Beijing, China. ningning301@126.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Ning
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China. lixiaobo@ems.hrbmu.edu.cn.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D042822:Genomic Instability; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D016601:RNA-Binding Proteins / Q000235:genetics*; D015398:Signal Transduction
chemical_list: C516326:LIN28B protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C487931:mirnlet7 microRNA, human