title: Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder.
abstract: The sense of hearing is the fastest of our senses and provides the first all-or-none action potential in the auditory nerve in less than four milliseconds. Short stimulus evoked latencies and their minimal variability are hallmarks of auditory processing from spiral ganglia to cortex. Here, we review how even small changes in first spike latencies (FSL) and their variability (jitter) impact auditory temporal processing. We discuss a number of mouse models with degraded FSL/jitter whose mutations occur exclusively in the central auditory system and therefore might serve as candidates to investigate the cellular mechanisms underlying auditory processing disorders (APD).
authors.affiliation: Division of Neurobiology, Department Biology II, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany. Electronic address: cks@bio.lmu.de.
authors.forename: Conny
authors.initials: C
authors.lastname: Kopp-Scheinpflug
authors.affiliation: VM Bloedel Hearing Research Center and Departments of Otolaryngology-HNS and Pharmacology, University of Washington, Seattle, WA, USA; Department of Otolaryngology-HNS, University of Washington, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Tempel
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology*; D001307:Auditory Perception; D001308:Auditory Perceptual Disorders / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D004195:Disease Models, Animal; D016057:Evoked Potentials, Auditory, Brain Stem; D020022:Genetic Predisposition to Disease; D006309:Hearing; D006801:Humans; D051379:Mice; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010641:Phenotype; D011930:Reaction Time; D013067:Speech Perception; D009435:Synaptic Transmission; D013997:Time Factors
chemical_list: D009419:Nerve Tissue Proteins
keywords: Auditory brainstem responses; Auditory processing disorder; First spike latency; Jitter; Kv1.1; Quivering; βIV-spectrin