title: Multifaceted control of adult SVZ neurogenesis by the vascular niche.
abstract: The subventricular zone is one of the 2 germinal niches of the adult brain where neural stem cells (NSC) generate new neurons and glia throughout life. NSC behavior is controlled by the integration of intrinsic signals and extrinsic cues provided by the surrounding microenvironment, or niche. Within the niche, the vasculature has emerged as a critical compartment, to which both neural stem cells and transit-amplifying progenitors are closely associated. A key function of the vasculature is to deliver blood-borne and secreted factors that promote proliferation and lineage progression of committed neural progenitors. We recently found that, in contrast to the established role of soluble cues, juxtacrine signals on vascular endothelial cells maintain neural stem cells in a quiescent and undifferentiated state through direct cell-cell interactions. In this perspective, we discuss how, through these apparently opposing signals, the vascular niche might coordinate stem cell decisions between maintenance and proliferation.
authors.affiliation: a Cell Interactions and Cancer Group; MRC Clinical Sciences Center; Imperial College London ; London , UK.
authors.forename: Cristina
authors.initials: C
authors.lastname: Ottone
authors.forename: Simona
authors.initials: S
authors.lastname: Parrinello
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism; D036388:Ephrin-B2 / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism*; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D020933:Neurotrophin 3; D019899:Paracrine Communication; D000072099:Serrate-Jagged Proteins; D055153:Stem Cell Niche
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C515255:CXCL12 protein, human; D002135:Calcium-Binding Proteins; D054377:Chemokine CXCL12; D036388:Ephrin-B2; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C000595808:NTF3 protein, human; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D000072099:Serrate-Jagged Proteins; C579455:BDNF protein, human
keywords: adult neurogenesis; cell-cell signaling; neural stem cells; quiescence; subventricular zone; vascular niche