title: [Effect of Radix euphorbiae pekinensis extract on bioavailability of paclitaxel after their oral co-administration].
abstract: OBJECTIVE
  To evaluate the effect of Radix euphorbiae pekinensis extract on the permeability and bioavailability of paclitaxel co-administered orally.
  
  
  METHODS
  Based on Ussing Chamber and in vivo experiment, the permeability and bioavailability of paclitaxel were evaluated after oral co-administration with radix euphorbiae pekinensis in rats. The contents of paclitaxel in the permeates and the blood samples were determined using HPLC and LC-MS/MS method, respectively.
  
  
  RESULTS
  In Radix euphorbiae pekinensis co-administration group, the Papp of the mucosal-to-serosal (M-S) transport or serosal-to-mucosal transport (S-M) of paclitaxel in the jejunum or ileum segment differed significantly from those in verapamil co-administration group and blank control group (P<0.05), but the Papp of S-M transport in the colon showed no significant difference from that in the blank control group. In the blank group, the average absolute bioavailability (AB%) of orally administered paclitaxel was only 2.81%, compared to that of 7.63% in radix euphorbiae pekinensis group. The average AB% in verapamil group was about 1.5 times that of the blank group.
  
  
  CONCLUSIONS
  Co-administration of Radix euphorbiae pekinensis extract can increase the bioavailability of orally administered paclitaxel.
authors.affiliation: Longjiang Hospital of Shunde District, Foshan 528318, China. E-mail: 1390729887@qq.com.
authors.forename: Minghua
authors.initials: M
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Peng
authors.forename: Fuheng
authors.initials: F
authors.lastname: Yang
authors.forename: Sijia
authors.initials: S
authors.lastname: Liu
authors.forename: Shengqi
authors.initials: S
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001692:Biological Transport; D002851:Chromatography, High Pressure Liquid; D019665:Euphorbiaceae / Q000737:chemistry*; D017239:Paclitaxel / Q000493:pharmacokinetics*; D010539:Permeability; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D053719:Tandem Mass Spectrometry; D014700:Verapamil
chemical_list: D010936:Plant Extracts; D014700:Verapamil; D017239:Paclitaxel