title: Cytosine-type nucleosides from marine-derived Streptomyces rochei 06CM016.
abstract: Rocheicoside A (3), a nucleoside analog possessing a novel 5-(hydroxymethyl)-5-methylimidazolidin-4-one substructure, was isolated from marine-derived actinomycete Streptomyces rochei 06CM016, together with a new (4) and three known compounds. Structures of the new metabolites were elucidated by one-dimensional ((1)H and (13)C) and 2D NMR (COSY, HMQC and HMBC) and HR-TOF-MS analyses. All the metabolites exhibited significant antimicrobial activity. A plausible mechanism was proposed for compound 3's formation from amicetin.
authors.affiliation: Ege University, Department of Biology, Basic and Industrial Microbiology Section, Izmir, Turkey.
authors.forename: Semiha Çetinel
authors.initials: SÇ
authors.lastname: Aksoy
authors.affiliation: Ege University, Department of Biology, Basic and Industrial Microbiology Section, Izmir, Turkey.
authors.forename: Ataç
authors.initials: A
authors.lastname: Uzel
authors.affiliation: Ege University, Department of Bioengineering, Izmir, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Bedir
mesh_terms: D003596:Cytosine / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D003596:Cytosine