title: Treatment outcomes of concurrent chemoradiotherapy for locally advanced sinonasal squamous cell carcinoma: A single-institution study.
abstract: CONCLUSIONS
  CCRT is a potential treatment option for locally advanced sinonasal SCC in terms of organ preservation.
  
  
  OBJECTIVE
  Concurrent chemoradiotherapy (CCRT) is increasingly used for patients with advanced head and neck cancer to preserve organ function and improve survival. In the present study, treatment outcomes were compared between surgery and post-operative radiotherapy (PORT) and CCRT in patients with locally advanced sinonasal squamous cell carcinoma (SCC).
  
  
  METHODS
  The records of 30 patients with non-metastatic stage III and IV sinonasal SCC were retrospectively reviewed. Fifteen patients were treated with CCRT and 15 patients underwent PORT.
  
  
  RESULTS
  The locoregional recurrence-free, distant metastasis-free, disease-free, disease-specific, and overall survival rates did not differ between PORT and CCRT groups. In addition, there were no significant differences in incidence rates of acute and chronic toxicities between the two groups.
authors.affiliation: a 1 Department of Otolaryngology.
authors.forename: Ji Heui
authors.initials: JH
authors.lastname: Kim
authors.affiliation: a 1 Department of Otolaryngology.
authors.forename: Yoon Se
authors.initials: YS
authors.lastname: Lee
authors.affiliation: a 1 Department of Otolaryngology.
authors.forename: Yoo-Sam
authors.initials: YS
authors.lastname: Chung
authors.affiliation: a 1 Department of Otolaryngology.
authors.forename: Yong Ju
authors.initials: YJ
authors.lastname: Jang
authors.affiliation: b 2 Department of Oncology.
authors.forename: Sung-Bae
authors.initials: SB
authors.lastname: Kim
authors.affiliation: c 3 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine , Seoul, Republic of Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Lee
authors.affiliation: a 1 Department of Otolaryngology.
authors.forename: Bong-Jae
authors.initials: BJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D002681:China / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends
chemical_list: D000970:Antineoplastic Agents
keywords: Concurrent chemoradiotherapy; paranasal sinus; radiotherapy; squamous cell carcinoma; surgery