title: [Levonorgestrel-releasing intrauterine system Mirena® (Bayer) for the prevention and treatment of endometrial adenocarcinoma and the incidence of other malignancies in women].
abstract: The use of hormone-releasing intrauterine devices has been on the increase for the last three decades. To date, evidence of their long-term efficiency is available. The aim of the present paper was to briefly review beneficial prophylactic effects of the levonorgestrel-releasing intrauterine system on the incidence of a variety of malignancies in women. Such an influence is of a particular importance in the light of the currently observed increased prevalence of endometrial and cervical adenocarcinomas. Low-dose releasing intrauterine systems are also available, but the hard evidence-based medical data have been derived primarily for Mirena® (Bayer) device, which topically releases from 20 to 14 pg of levonorgestrel daily. Consequently the risk of developing endometrial carcinoma in Mirena® users is lowered by as much as 50% compared with the general population risk To a lesser extent, the intrauterine system decreases the risk for cervical adenocarcinoma and squamous cell carcinoma, as well as ovarian, pancreas, and lung carcinomas. In one population-based study Mirena® increased the risk for breast carcinoma by approximately 20%, whereas a number of other studies failed to demonstrate such a hazard. In the recent decades of the increased predominance of insulin resistance and obesity and an occurrence of hormone-dependent carcinomas at earlier age, a broad application of levonorgestrel-releasing intrauterine systems may become a particularly important component of primary prevention of malignancies in women. Both obese and overweight patients seem perfect candidates for such a hormonal intervention.
authors.forename: Maciej
authors.initials: M
authors.lastname: Jóźwik
authors.forename: Marcin
authors.initials: M
authors.lastname: Jóźwik
authors.forename: Beata
authors.initials: B
authors.lastname: Modzelewska
authors.forename: Marta
authors.initials: M
authors.lastname: Niewińska
authors.forename: Michał
authors.initials: M
authors.lastname: Jóźwik
mesh_terms: D000230:Adenocarcinoma / Q000517:prevention & control; D018269:Carcinoma, Endometrioid / Q000517:prevention & control*; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004714:Endometrial Hyperplasia / Q000517:prevention & control; D016889:Endometrial Neoplasms / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel / Q000008:administration & dosage*
chemical_list: D003271:Contraceptive Agents, Female; D016912:Levonorgestrel