title: Prophylactic Radiotherapy to Intervention Sites in Malignant Pleural Mesothelioma--Single-institution Experience and Literature Review.
abstract: OBJECTIVE
  To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM).
  
  
  METHODS
  From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out with 3 × 7=21 Gy with 6-18 MeV electrons.
  
  
  RESULTS
  The mean follow-up period was 14.4 months (range=0-37 months). At the time of the analysis, 20 patients were alive. Three patients had developed a local recurrence within the irradiated site, representing a local recurrence rate of 5.7%. Toxicity was low, with transient grade I erythema found in 20.7% of patients. No grade II or higher toxicity was observed.
  
  
  CONCLUSIONS
  Our simple and time-saving RT approach to interventional sites in patients with MPM was both effective and well-tolerated. This approach is easily integrated into general treatment concepts. Until publication of results from prospective randomized trials, prophylactic RT to intervention sites should remain standard.
authors.affiliation: Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany Department of Radiation Oncology, University of Lübeck, Lübeck, Germany s.janssen@strahlentherapie.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Janssen
authors.affiliation: Department of Pneumology, Siloah Hospital, Hannover, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Schönhofer
authors.affiliation: Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
authors.forename: Dirk
authors.initials: D
authors.lastname: Rades
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008654:Mesothelioma / Q000473:pathology / Q000532:radiotherapy*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D010997:Pleural Neoplasms / Q000473:pathology / Q000532:radiotherapy*
keywords: Malignant mesothelioma; intervention-site metastases; procedure-tract metastases; prophylactic radiotherapy