title: MgI2 -mediated chemoselective cleavage of protecting groups: an alternative to conventional deprotection methodologies.
abstract: The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports.
authors.affiliation: Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM, CC17-03, Pl. E. Bataillon, 34095 Montpellier Cedex 5 (France).
authors.forename: Mathéo
authors.initials: M
authors.lastname: Berthet
authors.affiliation: Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM, CC17-03, Pl. E. Bataillon, 34095 Montpellier Cedex 5 (France).
authors.forename: Florian
authors.initials: F
authors.lastname: Davanier
authors.affiliation: IMMM UMR 6283 CNRS, Université du Maine, Le Mans (France).
authors.forename: Gilles
authors.initials: G
authors.lastname: Dujardin
authors.affiliation: Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM, CC17-03, Pl. E. Bataillon, 34095 Montpellier Cedex 5 (France).
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.affiliation: Institut des Biomolécules Max Mousseron, IBMM, UMR-5247, CNRS, Université Montpellier, ENSCM, CC17-03, Pl. E. Bataillon, 34095 Montpellier Cedex 5 (France). isabelle.parrot@um2.fr.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Parrot
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D004951:Esterification; D004952:Esters / Q000737:chemistry; D055772:Green Chemistry Technology; D007454:Iodides / Q000138:chemical synthesis / Q000737:chemistry*; D017616:Magnesium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques / Q000379:methods*; D012997:Solvents
chemical_list: D000596:Amino Acids; D004952:Esters; D007454:Iodides; D017616:Magnesium Compounds; D012997:Solvents; C510205:magnesium iodide
keywords: carbamates; cleavage reactions; esters; protecting groups; solid-phase synthesis