title: [Expression of USP9X in Non-small Cell Lung Cancer and Its Clinical Significance].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of ubiquitin-specific protease 9X (USP9X) protein in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  USP9X proteins were detected in 71 cases of NSCLC and 20 cases of benign pulmonary tissues by immunohistochemical staining. The correlation between USP9X expression and 51 NSCLC clinicopathological parameters as well as survival rates were indicated.
  
  
  RESULTS
  Higher rate [69. 0% (49/71)] of the expression of USP9X was observed in NSCLC samples, compared with 20. 0% (4/20) in benign pulmonary tissues (P<0. 001). Furthermore, the expression of USP9X proteins was positively associated with both histological types and lymph node metastasis (P<0. 05). The survival analysis showed that the survival rate was lower in patients with positive expressions of USP9X than in patients with negative expressions (P< 0. 05). USP9X expression, together with histological types and TNM stage was an independent predictor for overall survival in the multivariate Cox regression model (P < 0. 05).
  
  
  CONCLUSIONS
  Up-regulation of USP9X plays an important role in the invasion and progression of NSCLC and could be considered as a prognostic predictor for NSCLC.
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.forename: Qian
authors.initials: Q
authors.lastname: Hu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Shan-ling
authors.initials: SL
authors.lastname: Liu
authors.forename: He
authors.initials: H
authors.lastname: Wang
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008207:Lymphatic Metastasis; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C506234:USP9X protein, human; D043222:Ubiquitin Thiolesterase