title: AGO Austria recommendations for genetic testing of patients with ovarian cancer.
abstract: In Austria, 700 women are diagnosed every year with ovarian carcinoma. Approximately 15% of the patients with epithelial ovarian cancer have a germline mutation in the BRCA1 or BRCA2 genes. The increased incidence of breast and/or ovarian cancer in genetically related family members has given rise to the term "hereditary breast and ovarian cancer syndrome" (HBOC). Some 25-55% of these in-family diseases are attributed to germline mutations of BRCA1 or BRCA2, and approximately 5-10% to other known tumor predisposition syndromes. The remaining persons may carry mutations in as yet unidentified genes. HBOC caused by BRCA1 and BRCA2 mutations is an autosomal dominant disorder with high penetrance. BRCA1 and BRCA2 encode for so-called tumor suppressor proteins. Inherited functional mutations of these genes cause loss of function of the respective allele. Loss of function of the second allele causes complete loss of the corresponding protein and facilitates the development of a malignancy.The Association of Gynecologic Oncology recommends that testing for a germline mutation in BRCA1 or BRCA2 should be offered to all patients with epithelial ovarian cancer. When mutations in BRCA1, BRCA2, or other cancer-susceptibility genes have been identified, patients with ovarian carcinoma can be treated with new, innovative therapies. This recommendation is intended as a standard guideline for genetic testing of patients with an ovarian carcinoma.
authors.affiliation: Clinic for Gynecology and Obstetrics, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria, christian.marth@uki.at.
authors.forename: Christian
authors.initials: C
authors.lastname: Marth
authors.forename: Michael
authors.initials: M
authors.lastname: Hubalek
authors.forename: Edgar
authors.initials: E
authors.lastname: Petru
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Christian
authors.initials: C
authors.lastname: Schauer
authors.forename: Tonja
authors.initials: T
authors.lastname: Scholl-Firon
authors.forename: Christian F
authors.initials: CF
authors.lastname: Singer
authors.forename: Johannes
authors.initials: J
authors.lastname: Zschocke
authors.forename: Alain G
authors.initials: AG
authors.lastname: Zeimet
mesh_terms: D001317:Austria; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D055088:Early Detection of Cancer / Q000592:standards*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000592:standards*; D006176:Gynecology / Q000592:standards; D006801:Humans; D008495:Medical Oncology / Q000592:standards*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017410:Practice Guidelines as Topic
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D014408:Biomarkers, Tumor