title: [Sleep disorders and circadian rhythms in diseases of the cardiovascular system].
abstract: OBJECTIVE
  To study disturbances of sleep and circadian rhythms in patients with cardiovascular diseases taking into account the level of melatonin secretion and to optimize a complex approach to their treatment.
  
  
  METHODS
  The study included patients with cardiovascular diseases with- (n=121) and without (n=105) cerebrovascular diseases (CVD). All patients received melaxen in dose 3 mg daily 30-40 min before sleep. Examination of patients included assessment of neurological status, psychometric scales, the definition of circadian rhythm of the heart and blood pressure, determination of 6-SOMT in daily urine.
  
  
  RESULTS
  Pathological changes in circadian rhythms affected sleep disturbances, emotional and cognitive disorders and were associated with a reduction in the level of 6-SOMT in the urine. These changes were most pronounced in patients with CVD and stroke. The inclusion of melaxen in the comprehensive regimen of treatment improved sleep, reduced mood disorders and normalized the circadian heart rate profile and blood pressure.
  
  
  CONCLUSIONS
  The data obtained allowed to consider melaxen as an effective tool in the complex therapy of patients with CVD.
authors.affiliation: Pirogov Russian National Research Medical University, Moscow; Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Kostenko
authors.affiliation: Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow.
authors.forename: L V
authors.initials: LV
authors.lastname: Petrova
authors.affiliation: Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine, Moscow.
authors.forename: M A
authors.initials: MA
authors.lastname: Eneeva
authors.affiliation: Pirogov Russian National Research Medical University, Moscow.
authors.forename: P R
authors.initials: PR
authors.lastname: Kamchatnov
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications*; D002940:Circadian Rhythm; D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology; D020178:Sleep Disorders, Circadian Rhythm / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D020521:Stroke / Q000453:epidemiology
chemical_list: C054513:6-sulfatoxymelatonin; D008550:Melatonin