title: Measurement of sST2 is comparable to PlGF in the diagnosis of early-onset pre-eclampsia.
abstract: A diagnostic test to confirm pre-eclampsia would be beneficial for the clinical management of the syndrome. The Triage PlGF test is able to confirm pre-eclampsia with high accuracy, with the greatest efficacy at <35weeks gestation. We recently found that the anti-inflammatory protein sST2 is elevated in the plasma of pre-eclamptic women compared to normal controls. Here sST2 and PlGF are compared in early-onset and late-onset pre-eclamptic women. sST2 was found to be an equally good diagnostic tool for early-onset (sST2 AUC 0.944 versus PlGF AUC 0.995; not significant) but not late-onset disease.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK. Electronic address: jen.southcombe@obs-gyn.ox.ac.uk.
authors.forename: Jennifer H
authors.initials: JH
authors.lastname: Southcombe
authors.affiliation: Departments of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Samantha J
authors.initials: SJ
authors.lastname: Benton
authors.affiliation: Departments of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Departments of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: von Dadelszen
authors.affiliation: Oxford Fertility Unit and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
authors.forename: Tim
authors.initials: T
authors.lastname: Child
authors.affiliation: Critical Diagnostics, San Diego, CA, USA.
authors.forename: James V
authors.initials: JV
authors.lastname: Snider
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
authors.forename: Christopher W G
authors.initials: CW
authors.lastname: Redman
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
authors.forename: Ian L
authors.initials: IL
authors.lastname: Sargent
authors.affiliation: Oxford Fertility Unit and Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Granne
keywords: Inflammation; Maternal immunity; PlGF; Pre-eclampsia; sST2