title: Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.
abstract: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in Chinese pediatric patients. To date, the genetic susceptibility to AD in this population has not been fully clarified. Three single nucleotide polymorphisms have previously been associated with AD in Europeans, rs2897442 (KIF3A), rs479844 (OVOL1) and rs2164983 (ACTL9). To verify the correlation between AD and these three SNPs in the Chinese pediatric population, we conducted a case-control study including 235 pediatric patients with AD and 200 health controls. We confirmed the correlation between rs2897442 and rs479844 and AD in this population at both the genotype and allele levels. Statistical analysis showed that the C allele of rs2897442 is associated with an increased risk of developing AD, while the A allele of rs479844 is associated with a reduced risk. No correlation between rs2164983 and AD was identified. Our study indicates that KIF3A and OVOL1 are involved in the development of AD in the Chinese pediatric population.
authors.affiliation: Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China.
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Kang
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Microbiology, Children's Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China.
authors.forename: Pan
authors.initials: P
authors.lastname: Fu
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China.
authors.forename: Shuxian
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China; Central Laboratory, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China.
authors.forename: Ming
authors.initials: M
authors.lastname: Guan
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China. Electronic address: xujinhua2012@sina.com.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Dermatology, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai 200040, PR China. Electronic address: xufeng@medmail.com.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
mesh_terms: D000199:Actins / Q000235:genetics*; D000293:Adolescent; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D004268:DNA-Binding Proteins / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D016547:Kinesins / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C000603397:ACTL9 protein, human; D000199:Actins; D004268:DNA-Binding Proteins; C087415:KIF3A protein, human; C490319:OVOL1 protein, human; D014157:Transcription Factors; D016547:Kinesins
keywords: ACTL9; Atopic dermatitis; KIF3A; OVOL1