title: EVALUATION OF PARA- AND PERIRENAL FAT THICKNESS AND ITS ASSOCIATION WITH METABOLIC DISORDERS IN POLYCYSTIC OVARY SYNDROME.
abstract: OBJECTIVE
  The aim of this study was to compare para- and perirenal fat (PFT) and subcutaneous abdominal fat (SFT) measurements between patients with polycystic ovary syndrome (PCOS) and control subjects and to assess the possible relation with metabolic disorders.
  
  
  METHODS
  This study included 68 patients with PCOS and 40 age- and body mass index (BMI)-matched healthy controls. We evaluated anthropometric, hormonal, and metabolic parameters, and abdominal ultrasonography was performed to measure PFT and SFT.
  
  
  RESULTS
  The mean PFT values were 6.1 ± 2.9 mm in patients with PCOS and 4.3 ± 2.3 mm in healthy controls (P = .002). SFT values were also higher in the patient group (9.6 ± 5 mm) compared to healthy subjects (3.5 ± 0.5 mm) (P = .017). A significant positive correlation was found between PFT and BMI (r = 0.368), waist circumference (WC) (r = 0.441), Ferriman-Gallwey (FG) score (r = 0.313), blood pressure (systolic, SBP, r = 0.213; diastolic, DBP, r = 0.215), plasma glucose (r = 0.195), homeostasis model assessment-insulin resistance (HOMA-IR, r = 0.273), SFT (r = 0.555). Conversely, negative correlations were found between PFT and estradiol (r = -0.218) and sex hormone-binding globulin (SHBG, r = -0.304). Nonobese PCOS patients (6.1 ± 3.07 mm) had higher PFT values than nonobese controls (3.47 ± 1.5 mm); however, SFT measurements did not differ (P = .086). In multiple linear regression analysis, SFT (P = .006) was a significant and independent predictor for PFT, along with WC (P = .023). In a stepwise model, SFT was the predictor of PFT (P = .001).
  
  
  CONCLUSIONS
  PFT values were higher particularly in nonobese PCOS patients compared to nonobese control subjects. There was a significant interaction between PCOS and obesity on PFT.
authors.forename: Serap Baydur
authors.initials: SB
authors.lastname: Sahin
authors.forename: Tugba
authors.initials: T
authors.lastname: Durakoglugil
authors.forename: Teslime
authors.initials: T
authors.lastname: Ayaz
authors.forename: Osman Zikrullah
authors.initials: OZ
authors.lastname: Sahin
authors.forename: Emre
authors.initials: E
authors.lastname: Durakoglugil
authors.forename: Fatih
authors.initials: F
authors.lastname: Sumer
authors.forename: Ezgi
authors.initials: E
authors.lastname: Aktas
authors.forename: Nese
authors.initials: N
authors.lastname: Alyildiz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D007668:Kidney / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging* / Q000378:metabolism*; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult