title: Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv.
abstract: A new diketopiperazine alkaloid named spirotryprostatin K (1), and five known alkaloids, spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H),2'-[2H]-indole]-3',5,10(1'H) trione (2), 6-methoxyspirotryprostatin B (3), pseurotin A (4), N-β-acetyltryptamine (5), and lumichrome (6) were isolated from the endophytic fungus Aspergillus fumigatus. The structure and the absolute configuration of spirotryprostatin K were established by extensive spectroscopic analyses, acid hydrolysis and ECD calculations. Pseurotin A exhibited indirect anti-inflammatory activity by suppressing the lipopolysaccharide-induced proinflammatory factors in BV2 microglial cells, with an IC50 of 5.20 µM.
authors.affiliation: Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Shi
authors.affiliation: Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.
authors.forename: Xiao-Zhong
authors.initials: XZ
authors.lastname: Chen
authors.affiliation: Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liuyunbao@imm.ac.cn.
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Liu
mesh_terms: D001232:Aspergillus fumigatus / Q000737:chemistry* / Q000378:metabolism; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry* / Q000302:isolation & purification; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C531255:6-methoxyspirotryprostatin B; D026121:Indole Alkaloids; D011760:Pyrrolidinones; D013141:Spiro Compounds; C012013:pseurotin
keywords: Aspergillus fumigatus; Erythrophloeum fordii Oliv.; endophytic fungus