title: Intrapartum mean platelet volume is not a useful predictor of new-onset delayed postpartum pre-eclampsia.
abstract: OBJECTIVE
  To determine whether intrapartum mean platelet volume (MPV) can predict new-onset delayed postpartum pre-eclampsia.
  
  
  METHODS
  In a retrospective study, data were obtained for women with delayed postpartum pre-eclampsia (≥48 hours after delivery) who attended the Detroit Medical Center, Detroit, MI, USA, between January 2002 and July 2010. Patients were divided into two subgroups: new-onset delayed postpartum pre-eclampsia (no history of hypertensive disorder before 48 hours after delivery) and other late-onset/delayed postpartum pre-eclampsia (history of hypertensive disorders). Cases with no hypertensive disorders paired by delivery date were selected as controls. Receiver operating characteristic (ROC) curves were used to determine whether MPV could distinguish between cases and controls.
  
  
  RESULTS
  Data for 130 cases of new-onset delayed postpartum pre-eclampsia, 71 cases of other late-onset/delayed postpartum pre-eclampsia, and 405 controls were collected. MPV was significantly different between the pre-eclampsia subgroups (P=0.007). ROC curves showed that MPV significantly distinguished new-onset delayed postpartum pre-eclampsia cases (area under the curve 0.6, 95% confidence interval 0.5-0.6; P=0.02), with a sensitivity and specificity of 58.1% and 55.4%, respectively.
  
  
  CONCLUSIONS
  Although MPV was significantly lower in women who went on to develop new-onset delayed postpartum pre-eclampsia than among controls, it is not a useful predictor. The low MPV suggests a different mechanism for the development of new-onset delayed postpartum pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University/Detroit Medical Center, Detroit, MI, USA. Electronic address: gvilchez@med.wayne.edu.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Vilchez
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Lutherville, MD, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Londra
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University/Detroit Medical Center, Detroit, MI, USA.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Hoyos
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Sokol
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
authors.forename: Ray
authors.initials: R
authors.lastname: Bahado-Singh
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D063847:Mean Platelet Volume; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000453:epidemiology*; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D055815:Young Adult
keywords: Mean platelet volume; Platelet count; Postpartum period; Pre-eclampsia