title: [Effectiveness Of 2% And 4% Papain Gels In The Healing Of Venous Ulcers].
abstract: OBJECTIVE
  To analyze the effectiveness of 2% and 4% papain gels in tissue repair of venous ulcers.
  
  
  METHODS
  Quasi-experimental study with consecutive sample of 16 patients with 30 venous ulcers treated at the outpatient clinic of a teaching hospital, from April to November in 2011, using a form for clinical assessment of the patient and its lesion. Variables were analyzed by Wilcoxon and McNemar test (p < 0.05).
  
  
  RESULTS
  Most participants were female; aged between 51 and 59 years; obese; with hypertension. Regarding ulcers, there was an average decrease of 7.9 cm2 (50% of its original size) in 90 days; 20% of the ulcers completely healed within 56.67 days. There was an increase in epithelialization, significant reduction in the slough and edema, improved depth, in the type and amount of exudate (p < 0.0001).
  
  
  CONCLUSIONS
  2% and 4% papain gels were effective in healing venous ulcers.
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Andréa Pinto Leite
authors.initials: AP
authors.lastname: Ribeiro
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Beatriz Guitton Renaud Baptista de
authors.initials: BG
authors.lastname: Oliveira
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Marja Ferreira
authors.initials: MF
authors.lastname: Soares
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Bruna Maiara Ferreira
authors.initials: BM
authors.lastname: Barreto
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Débora Omena
authors.initials: DO
authors.lastname: Futuro
authors.affiliation: Universidade Federal Fluminense, Niteroi, RJ, Brazil.
authors.forename: Selma Rodrigues de
authors.initials: SR
authors.lastname: Castilho
mesh_terms: D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010206:Papain / Q000008:administration & dosage*; D016896:Treatment Outcome; D014647:Varicose Ulcer / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; D010206:Papain