title: Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia.
abstract: Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone-induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF-α, IL-1β, IL-6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed. The obese rats had a higher prostate weight compared with controls. S. repens significantly decreased prostate weight, total nitrites, and malondialdehyde; improved total glutathione, SOD, and catalase activity; and significantly reduced inflammatory (TNF-α, IL-1β and IL-6) and growth factors (VEGF and FGFb). S. repens showed high antioxidant and antiinflammatory activity in obese rats, suggesting that their use could be beneficial in the treatment of benign prostatic hyperplasia.
authors.affiliation: Departamento Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Juventino
authors.initials: J
authors.lastname: Colado-Velázquez
authors.affiliation: Departamento Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mailloux-Salinas
authors.affiliation: Departamento Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Jml
authors.initials: J
authors.lastname: Medina-Contreras
authors.affiliation: Departamento de Biología Molecular, Instituto Nacional de Cardiología, Ignacio Chávez, Mexico City, Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Cruz-Robles
authors.affiliation: Departamento Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Bravo
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D015850:Interleukin-6; D008297:Male; D009765:Obesity / Q000150:complications / Q000188:drug therapy*; D018384:Oxidative Stress; D008517:Phytotherapy; D010936:Plant Extracts; D011470:Prostatic Hyperplasia / Q000150:complications / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D028024:Serenoa; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A
chemical_list: D000726:Androgen Antagonists; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015850:Interleukin-6; D010936:Plant Extracts; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; C040972:saw palmetto extract
keywords: Serenoa repens; growth factors; obesity; oxidative stress; prostatic hyperplasia; testosterone