title: Clinical Management of Patients With Parenteral Nutrition-Dependent Short Bowel Syndrome During Teduglutide Therapy.
abstract: Patients with intestinal failure, who are dependent on parenteral nutrition (PN) to supplement their limited absorption of dietary nutrients, are subject to complications associated with long-term PN therapy. Medication therapy that results in improved dietary nutrient absorption may enable these patients to reduce or even become independent from PN therapy and its related complications. The glucagon-like peptide 2 (GLP-2) analogue teduglutide was approved for use in such patients by the U.S. Food and Drug Administration in 2012.
  
  
  
  The purpose of this article is to describe the experience of 7 patients with PN-dependent intestinal failure who were treated with teduglutide by a single center that had been involved in the teduglutide clinical trials.
  
  
  
  Two patients who were treated during the clinical trials and 5 others who were treated since teduglutide came to market in the United States are described. Protocols used to prepare and monitor patients with this drug and PN weaning and adverse event outcomes are presented.
  
  
  
  While some patients had uncomplicated PN reduction, others experienced various complications. Careful monitoring of patients' clinical course is needed during drug therapy.
authors.affiliation: University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania compherc@nursing.upenn.edu.|Clinical Nutrition Support Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.|Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Charlene
authors.initials: C
authors.lastname: Compher
authors.affiliation: University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania.|Clinical Nutrition Support Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Boullata
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Department of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Octavia
authors.initials: O
authors.lastname: Pickett-Blakely
authors.affiliation: Clinical Nutrition Support Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Phyllis
authors.initials: P
authors.lastname: Schiavone
authors.affiliation: Clinical Nutrition Support Services, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Nancy
authors.initials: N
authors.lastname: Stoner
authors.affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.|Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Kinosian
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D019468:Disease Management; D004305:Dose-Response Relationship, Drug; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D010455:Peptides / Q000627:therapeutic use*; D012778:Short Bowel Syndrome / Q000188:drug therapy* / Q000628:therapy*
chemical_list: D005765:Gastrointestinal Agents; D010455:Peptides; C494910:teduglutide
keywords: GLP-2; copper; intestinal failure; short bowel syndrome; teduglutide