title: Palladium-catalyzed oxalyl amide assisted direct ortho-alkynylation of arylalkylamine derivatives at δ and ε positions.
abstract: Palladium-catalyzed oxalyl amide directed ortho-alkynylation of arylalkylamine derivatives is reported for the first time. A wide variety of β-arylethamine and γ-arylpropamine derivatives are compatible with this protocol. This method provides a general means to synthesize substituted alkynylarylalkylamine derivatives, highlighting the ability of oxalyl amide in promoting C-H functionalization at unique δ and ε positions.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. yszhao@suda.edu.cn zengrunsheng@suda.edu.cn.
authors.forename: Mingyu
authors.initials: M
authors.lastname: Guan
authors.forename: Changpeng
authors.initials: C
authors.lastname: Chen
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Runsheng
authors.initials: R
authors.lastname: Zeng
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao