title: Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue.
abstract: Recently, vibration training is considered as a novel strategy of weight loss; however, its mechanisms are still unclear. In this study, normal or high-fat diet-induced rats were trained by whole body vibration for 8 weeks. We observed that the body weight and fat metabolism index, blood glucose, triglyceride, cholesterol, and free fatty acid in obesity rats decreased significantly compared with nonvibration group (n = 6). Although intrascapular BAT weight did not change significantly, vibration enhanced ATP reduction and increased protein level of the key molecule of brown adipose tissue (BAT), PGC-1α, and UCP1 in BAT. Interestingly, the adipocytes in retroperitoneal white adipose tissue (WAT) became smaller due to vibration exercise and had higher protein level of the key molecule of brown adipose tissue (BAT), PGC-1α, and UCP1 and inflammatory relative proteins, IL-6 and TNFα. Simultaneously, ATP content and PPARγ protein level in WAT became less in rats compared with nonvibration group. The results indicated that vibration training changed lipid metabolism in rats and promoted brown fat-like change in white adipose tissues through triggering BAT associated gene expression, inflammatory reflect, and reducing energy reserve.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Anatomy, Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Cao
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Zhibang
authors.initials: Z
authors.lastname: Song
authors.affiliation: Department of Pathogeny Biology, Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Yibo
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D052437:Adipocytes, Brown / Q000378:metabolism; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D059305:Diet, High-Fat; D004734:Energy Metabolism; D005786:Gene Expression Regulation / Q000528:radiation effects; D015850:Interleukin-6 / Q000378:metabolism; D050356:Lipid Metabolism / Q000235:genetics / Q000528:radiation effects; D024101:Mitochondrial Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009765:Obesity / Q000503:physiopathology / Q000628:therapy*; D051381:Rats; D014732:Vibration; D015431:Weight Loss
chemical_list: D015850:Interleukin-6; D024101:Mitochondrial Proteins; D000255:Adenosine Triphosphate