title: Serum Ischemia-Modified Albumin Levels in Experimental Model of Acute Pancreatitis.
abstract: OBJECTIVE
  To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Experimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013.
  
  
  METHODS
  Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope.
  
  
  RESULTS
  Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels.
  
  
  CONCLUSIONS
  The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.
authors.affiliation: Department of Pediatrics, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Naci
authors.initials: N
authors.lastname: Topaloglu
authors.affiliation: Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Kucuk
authors.affiliation: Department of Pediatrics, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tekin
authors.affiliation: Department of Pediatrics, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Yildirim
authors.affiliation: Department of Anesthesiology, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Erbas
authors.affiliation: Department of Anesthesiology, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Kiraz
authors.affiliation: Department of Clinical Biochemistry, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey.
authors.forename: Dilek Ulker
authors.initials: DU
authors.lastname: Cakir
authors.affiliation: Department of Pathology, Düzce Atatürk State Hospital, Düzce, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Erdem
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010183:Pancreatic Ducts; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D002097:C-Reactive Protein; D000681:Amylases; D000075462:Serum Albumin, Human