title: Zinc Finger Protein 259 (ZNF259) Polymorphisms are Associated with the Risk of Metabolic Syndrome in a Han Chinese Population.
abstract: BACKGROUND
  Zinc finger protein 259 (ZNF259) binds to the cytoplasmic domain of epidermal growth factor receptor (EGFR) in quiescent cells and contributes tolipid metabolism. This case and control study investigated the association between ZNF259 single nucleotide polymorphisms (SNPs) and metabolic syndrome (MetS).
  
  
  METHODS
  This study included 1,812 MetS patients and 2,036 controls from the Jilin province of Northeastern China. MetS was diagnosed using the International Diabetes Federation (IDF) criteria. Three ZNF259 SNPs (rs964184, rs2075290 and rs2075294) were genotyped using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS).
  
  
  RESULTS
  There were significant differences between metabolic syndrome and healthy control subjects for the ZNF259 rs964184 and rs2075290 genotypes. The minor alleles of both SNPs were associated with an increased risk of MetS and associated conditions (elevated triglycerides, elevated blood pressure, increased abdominal obesity, fasting hyperglycemia, and low HDL-C; p < 0.05). The distribution of haplotype G-G-G (rs964184, rs2075290 and rs2075294) was significantly different between MetS patients and controls (OR = 1.39; 95% CI, 1.24 - 1.56; p < 0.01).
  
  
  CONCLUSIONS
  This study demonstrated that ZNF259 variants were associated with elevated MetS risk in a Han Chinese population from the Jilin province of Northeastern China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wu
authors.forename: Shibin
authors.initials: S
authors.lastname: Yu
authors.forename: Shibin
authors.initials: S
authors.lastname: Wang
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Ziqi
authors.initials: Z
authors.lastname: Xu
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yingli
authors.initials: Y
authors.lastname: Fu
authors.forename: Yue
authors.initials: Y
authors.lastname: Qi
authors.forename: Jianwei
authors.initials: J
authors.lastname: Liu
authors.forename: Rao
authors.initials: R
authors.lastname: Fu
authors.forename: Changgui
authors.initials: C
authors.lastname: Kou
authors.forename: Yu
authors.initials: Y
authors.lastname: Yaqin
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D026901:Membrane Transport Proteins; D024821:Metabolic Syndrome / Q000208:ethnology / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C099746:ZPR1 protein, human