title: A voxel-based morphometry study of gray matter correlates of facial emotion recognition in bipolar disorder.
abstract: Facial emotion recognition (FER) is one of the many cognitive deficits reported in bipolar disorder (BD) patients. The aim of this study was to investigate neuroanatomical correlates of FER impairments in BD type I (BD-I). Participants comprised 21 euthymic BD-I patients without Axis I DSM IV-TR comorbidities and 21 healthy controls who were assessed using magnetic resonance imaging and the Penn Emotion Recognition Test (ER40). Preprocessing of images used DARTEL (diffeomorphic anatomical registration through exponentiated Lie algebra) for optimized voxel-based morphometry in SPM8. Compared with healthy subjects, BD-I patients performed poorly in on the ER40 and had reduced gray matter volume (GMV) in the left orbitofrontal cortex, superior portion of the temporal pole and insula. In the BD-I group, the statistical maps indicated a direct correlation between FER on the ER40 and right middle cingulate gyrus GMV. Our findings are consistent with the previous studies regarding the overlap of multiple brain networks of social cognition and BD neurobiology, particularly components of the anterior-limbic neural network.
authors.affiliation: Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Brazil. Electronic address: mailacln@gmail.com.
authors.forename: Maila de Castro L
authors.initials: Mde C
authors.lastname: Neves
authors.affiliation: Universidade Federal de Viçosa (UFV), Brazil.
authors.forename: Maicon Rodrigues
authors.initials: MR
authors.lastname: Albuquerque
authors.affiliation: Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Malloy-Diniz
authors.affiliation: Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Nicolato
authors.affiliation: Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Silva Neves
authors.affiliation: Laboratory of Psychiatric Neuroimaging (LIM-21), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
authors.forename: Fábio Luis
authors.initials: FL
authors.lastname: de Souza-Duran
authors.affiliation: Department of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), Universidade de São Paulo, Brazil.
authors.forename: Geraldo
authors.initials: G
authors.lastname: Busatto
authors.affiliation: Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Brazil.
authors.forename: Humberto
authors.initials: H
authors.lastname: Corrêa
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005239:Fear / Q000502:physiology; D005260:Female; D066128:Gray Matter / Q000473:pathology* / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D021641:Recognition, Psychology / Q000502:physiology*; D013223:Statistics as Topic
keywords: Bipolar disorder; Facial emotion recognition; Social cognition; Voxel-based morphometry (VBM)