title: Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs.
abstract: Anti-epileptic drugs (AEDs) have been widely used in patients with epilepsy. This study evaluated the adverse effects of two commonly prescribed AED monotherapies, carbamazepine (CBZ) and valproic acid (VPA). The aim of this study was to evaluate the influence of these anti-epileptic drugs on paraoxonase-1 (PON-1), glutathione S-transferase (GST) and acetyl cholinesterase (AChE) activities in the serum of adult patients with epilepsy. Of the 56 epileptic adults, 28 were given valproate, and the remaining 28 were given carbamazepine. Glutathione (GSH) levels in epilepsy patients receiving anti-epileptic drug treatment were insignificantly higher compared with controls. GST activity in epilepsy patients receiving anti-epileptic drug treatment was insignificantly lower compared with controls. PON1 and AChE activity in epilepsy patients receiving anti-epileptic drug treatment was significantly lower compared with controls. PON1 and AChE activities in the serum of patients treated with carbamazepine monotherapy were lower than in patients treated with valproic acid monotherapy.
authors.affiliation: Faculty of Sciences, Department of Chemistry, Biochemistry Division, Ataturk University , Turkey-Erzurum .
authors.forename: Mesut
authors.initials: M
authors.lastname: Işık
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Demir
authors.forename: Mahinur
authors.initials: M
authors.lastname: Kırıcı
authors.forename: Recep
authors.initials: R
authors.lastname: Demir
authors.forename: Fatma
authors.initials: F
authors.lastname: Şimşek
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Beydemir
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000097:blood; D002220:Carbamazepine / Q000627:therapeutic use*; D016022:Case-Control Studies; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D005978:Glutathione / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D000975:Antioxidants; D058851:GPI-Linked Proteins; D002220:Carbamazepine; D014635:Valproic Acid; D005982:Glutathione Transferase; C548244:ACHE protein, human; D000110:Acetylcholinesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D005978:Glutathione
keywords: Acetyl cholinesterase; anti-epileptic drugs; epilepsy; oxidative stress; serum