title: Extracorporeal membrane oxygenation for the treatment of adult sickle cell acute chest syndrome.
abstract: Sickle cell disease (SCD) is a hereditary haemoglobinopathy that results in polymerization of haemoglobin molecules and subsequent vaso-occlusion. A common cause of death in adults is acute chest syndrome (AChS) with resulting hypoxemic respiratory failure.Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used successfully in acutely reversible respiratory failure when conventional mechanical ventilation has been unable to adequately oxygenate and ventilate in a lung-protective fashion.We present an adult SCD patient with severe respiratory failure due to AChS, successfully treated with VV-ECMO. We also discuss some of the technical challenges and considerations when using ECMO in the SCD patient.
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK ken.parhar@albertahealthservices.ca.
authors.forename: Ken
authors.initials: K
authors.lastname: Parhar
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Barbora
authors.initials: B
authors.lastname: Parizkova
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Jones
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Kamen
authors.initials: K
authors.lastname: Valchanov
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Fowles
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Besser
authors.affiliation: Department of Haematology, Barts Health NHS Trust, London, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Telfer
authors.affiliation: Department of Haematology, Barts Health NHS Trust, London, UK.
authors.forename: Banu
authors.initials: B
authors.lastname: Kaya
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Alain
authors.initials: A
authors.lastname: Vuylsteke
authors.affiliation: Department of Anaesthesia and Intensive Care, Papworth Hospital, Cambridge, UK.
authors.forename: Antonio
authors.initials: A
authors.lastname: Rubino
mesh_terms: D056586:Acute Chest Syndrome / Q000209:etiology* / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans
keywords: acute chest syndrome; adult; chest crisis; extracorporeal membrane oxygenation; sickle cell disease