title: Vitamin D and asthma: current perspectives.
abstract: OBJECTIVE
  To review the current evidence on the relationship between vitamin D and asthma.
  
  
  RESULTS
  The rising morbidity and tremendous socioeconomic burden of asthma have prompted efforts to seek modifiable environmental and nutritional factors that contribute to the asthma epidemic. The association between low levels of vitamin D and asthma has been supported by many, but not all observational and epidemiologic studies. Recently, several controlled clinical trials have been undertaken to explore the effect of vitamin D supplementation on asthma control and respiratory tract infections. While some trials support the beneficial role of vitamin D supplementation in reducing asthma severity in children, several trials have found no beneficial role in adults.
  
  
  CONCLUSIONS
  Given the high prevalence of vitamin D insufficiency in children and adults worldwide and recent randomized controlled trials of vitamin D in asthma, supplementation with vitamin D cannot be recommended as adjunctive therapy for asthma.
authors.affiliation: The Divisions of Pulmonary and Critical Care Medicine, Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA.
authors.forename: Junfang
authors.initials: J
authors.lastname: Jiao
authors.forename: Mario
authors.initials: M
authors.lastname: Castro
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D014807:Vitamin D / Q000097:blood / Q000276:immunology; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology / Q000276:immunology
chemical_list: D014807:Vitamin D