title: Comparing the NIS vs. MRC and INCAT sensory scale through Rasch analyses.
abstract: We performed a comparison between Neuropathy Impairment Scale-sensory (NISs) vs. the modified Inflammatory Neuropathy Cause and Treatment sensory scale (mISS), and NIS-motor vs. the Medical Research Council sum score in patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and IgM monoclonal gammopathy of undetermined significance-related polyneuropathy (MGUSP). The ordinal data were subjected to Rasch analyses, creating Rasch-transformed (RT)-intervals for all measures. Comparison between measures was based on validity/reliability with an emphasis on responsiveness (using the patient's level of change related to the individually obtained varying SE for minimum clinically important difference). Eighty stable patients (GBS: 30, CIDP: 30, and MGUSP: 20) were assessed twice (entry: two observers; 2-4 weeks later: one observer), and 137 newly diagnosed or relapsing patients (GBS: 55, CIDP: 59, and IgM-MGUSP: 23) were serially examined with 12 months follow-up. Data modifications were needed to improve model fit for all measures. The sensory and motor scales demonstrated approximately equal and acceptable validity and reliability scores. Responsiveness scores were poor but slightly higher in RT-mISS compared to RT-NISs. Responsiveness was equal for the RT-motor scales, but higher in GBS compared to CIDP; responsiveness was poor in patients with MGUSP, suggesting a longer duration of follow-up in the latter group of patients.
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Thomas H P
authors.initials: TH
authors.lastname: Draak
authors.affiliation: Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Els K
authors.initials: EK
authors.lastname: Vanhoutte
authors.affiliation: Department of Neurology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Sonja I
authors.initials: SI
authors.lastname: van Nes
authors.affiliation: Department of Neurology, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Gorson
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: W-Ludo
authors.initials: WL
authors.lastname: Van der Pol
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Nicolette C
authors.initials: NC
authors.lastname: Notermans
authors.affiliation: Department of Neurological Sciences, Milan University, Humanitas Clinical Institute, Rozzano, Milan, Italy.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nobile-Orazio
authors.affiliation: Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lewis
authors.affiliation: Department of Neurology, Hôpital de la Salpêtrière, Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Léger
authors.affiliation: Department of Neurology, Catholique University of Louvain, Louvain, Belgium.
authors.forename: Peter Y K
authors.initials: PY
authors.lastname: Van den Bergh
authors.affiliation: Department of Clinical Neurosciences, Neuromuscular Diseases Unit National Neurological Institute "Carlo Besta", 3rd Neurology Unit, Milan, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lauria
authors.affiliation: Department of Neurology, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Vera
authors.initials: V
authors.lastname: Bril
authors.affiliation: Department of Neurology, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Hans
authors.initials: H
authors.lastname: Katzberg
authors.affiliation: Department of Neurology, Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
authors.forename: Michael P T
authors.initials: MP
authors.lastname: Lunn
authors.affiliation: Department of Neurology, Centre de Référence des Maladies Neuromusculaires et de la SLA, Hôpital de La Timone, Marseille, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Pouget
authors.affiliation: Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Anneke J
authors.initials: AJ
authors.lastname: van der Kooi
authors.affiliation: Department of Neurology, London Health Science Center, London, ON, Canada.
authors.forename: Angelika F
authors.initials: AF
authors.lastname: Hahn
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Leonard H
authors.initials: LH
authors.lastname: van den Berg
authors.affiliation: Department of Neurology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: Pieter A
authors.initials: PA
authors.lastname: van Doorn
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Cornblath
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Catharina G
authors.initials: CG
authors.lastname: Faber
authors.affiliation: Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.|Department of Neurology, Spaarne Hospital, Hoofddorp, The Netherlands.
authors.forename: Ingemar S J
authors.initials: IS
authors.lastname: Merkies
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D020275:Guillain-Barre Syndrome / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010265:Paraproteinemias / Q000503:physiopathology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000503:physiopathology*; D015203:Reproducibility of Results; D012677:Sensation / Q000502:physiology*; D012720:Severity of Illness Index; D055815:Young Adult
keywords: MRC; NIS; Rasch; mISS; responsiveness