title: Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer.
abstract: The costimulatory molecules B7-H3 and B7-H4 are overexpressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
authors.affiliation: Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Katharina
authors.initials: K
authors.lastname: Kreymborg
authors.affiliation: Columbia University Medical Center, New York, New York. Centre of Allergy and Environment (ZAUM), Technical University and Helmholtz Centre Munich, Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Haak
authors.affiliation: Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Rajmohan
authors.initials: R
authors.lastname: Murali
authors.affiliation: Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Joyce
authors.initials: J
authors.lastname: Wei
authors.affiliation: Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Waitz
authors.affiliation: Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Georg
authors.initials: G
authors.lastname: Gasteiger
authors.affiliation: Department of Pathology, University of Chicago, Chicago, Illinois.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Savage
authors.affiliation: Department of Immunology and Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Marcel R M
authors.initials: MR
authors.lastname: van den Brink
authors.affiliation: Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas. JAllison@mdanderson.org.
authors.forename: James P
authors.initials: JP
authors.lastname: Allison
mesh_terms: D000818:Animals; D060887:B7 Antigens / Q000235:genetics* / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D017353:Gene Deletion; D006801:Humans; D016130:Immunophenotyping; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D047368:Tumor Burden; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D060887:B7 Antigens; C486038:Cd276 protein, mouse; D012333:RNA, Messenger; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475824:Vtcn1 protein, mouse