title: [Dermatomyositis in a family of Working Kelpies].
abstract: Eight members of a family of Working Kelpies were presented with signs compatible with dermatomyositis. Alopecia, crusts, ulcerations of the skin, depigmentation of nasal planum and lips, onychodystrophy and atrophy of the masticatory muscles were present with varying degree. Histopathology of the skin, but not from muscles was performed in three dogs and confirmed the clinical diagnosis. Different immunomodulating drugs (steroids, cyclosporine, mycophenolate mofetil, pentoxifylline, doxycyline/niacinamid, omega-3 fatty acids and vitamin E) were used with variable success. Dermatomyositis is an immune-mediated disease and a genetic predisposition is known in humans and certain canine breeds, mainly Shetland Sheepdogs and Collies, but also for the Beauceron. The responsible genes have not been identified so far. It is assumed that the Working Kelpie derives from the Collie which could explain a hereditary predisposition in the Kelpie.
authors.affiliation: Dr. Anja Röthig, Klinik für Kleintiere, Justus-Liebig-Universität Gießen, Frankfurter Straße 126, 35392 Gießen, E-Mail: anja.roethig@vetmed.uni-giessen.de.
authors.forename: A
authors.initials: A
authors.lastname: Röthig
authors.forename: S
authors.initials: S
authors.lastname: Rüfenacht
authors.forename: M M
authors.initials: MM
authors.lastname: Welle
authors.forename: N
authors.initials: N
authors.lastname: Thom
mesh_terms: D000505:Alopecia / Q000473:pathology / Q000628:therapy / Q000662:veterinary; D000818:Animals; D003882:Dermatomyositis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D005260:Female; D008297:Male; D012883:Skin Ulcer / Q000473:pathology / Q000628:therapy / Q000662:veterinary
keywords: Ischemic dermatopathy; canine; vasculitis