title: Biocompatible organic charge transfer complex nanoparticles based on a semi-crystalline cellulose template.
abstract: Using a bio-inspired cellulose template, new charge transfer (CT) nanoparticles (NPs) with unique and intriguing emission properties are reported. Pyrene-modified 2,3-di-O-methyl cellulose formed CT complexes with small molecule acceptors, e.g. 7,7,8,8-tetracyanoquinodimethane (TCNQ), and exhibited aggregation-induced emission (AIE) in aqueous medium upon nanoparticle formation. The TCNQ-CT NPs showed multicolor fluorescence emissions at 370-400 nm, 602 nm and 777 nm, when excited at 330 nm, 485 nm and 620 nm respectively. The cellulose-TCNQ NPs are biocompatible and demonstrate an advance in the use of the CT mechanism for biomedical imaging applications both in vitro and in vivo.
authors.affiliation: Institute for Molecular Science, National Institutes of Natural Sciences, Department of Materials Molecular Science, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan. nagai@ims.ac.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagai
authors.forename: Jason B
authors.initials: JB
authors.lastname: Miller
authors.forename: Jia
authors.initials: J
authors.lastname: Du
authors.forename: Petra
authors.initials: P
authors.lastname: Kos
authors.forename: Mihaela C
authors.initials: MC
authors.lastname: Stefan
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Siegwart
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D002482:Cellulose / Q000737:chemistry / Q000493:pharmacokinetics*; D006367:HeLa Cells; D006801:Humans; D008545:Melanoma / Q000175:diagnosis*; D051379:Mice; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000175:diagnosis; D009570:Nitriles / Q000737:chemistry / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D009570:Nitriles; C013703:tetracyanoquinodimethane; D002482:Cellulose