title: p53 in survival, death and metabolic health: a lifeguard with a licence to kill.
abstract: The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates various metabolic pathways, helping to balance glycolysis and oxidative phosphorylation, limiting the production of reactive oxygen species, and contributing to the ability of cells to adapt to and survive mild metabolic stresses. Although these activities may be integrated into the tumour suppressive functions of p53, deregulation of some elements of the p53-induced response might also provide tumours with a survival advantage.
authors.affiliation: 1] Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. [2].
authors.forename: Flore
authors.initials: F
authors.lastname: Kruiswijk
authors.affiliation: 1] Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. [2].
authors.forename: Christiaan F
authors.initials: CF
authors.lastname: Labuschagne
authors.affiliation: Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.
authors.forename: Karen H
authors.initials: KH
authors.lastname: Vousden
mesh_terms: D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53