title: Mild encephalitis/encephalopathy with a reversible splenial lesion: five cases and a literature review.
abstract: The aim of this study was to explore the clinical characteristics and etiology of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in China by retrospectively analyzing five MERS cases from the Jiangsu Provincial Hospital within a total of 27 reported MERS cases from available Chinese literature. Most of the 27 cases originated near the eastern and southern parts of China. Ages for 23 MERS cases were under 30 years and the female-to-male ratio was 1:1.25. The major causes of MERS included infection, antiepileptic drug withdrawal, high-altitude cerebral edema, and cesarean section (C-section). Hyponatremia was also observed in 10 MERS cases. All patients had a complete recovery within a month. Steroids and IVIG were the most commonly used therapy for MERS, but their efficiency remained questionable.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Jing Jing
authors.initials: JJ
authors.lastname: Pan
authors.affiliation: Department of Neonatology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: You-Yan
authors.initials: YY
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lu
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China. wqm403-19h@163.com.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Hu
authors.affiliation: Department of Neonatology, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China. yy860507@126.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002675:Child, Preschool; D002681:China; D018352:Coronavirus Infections / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Hyponatremia; MRI; Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS); Splenium of the corpus callosum