title: Polysaccharide-Based Conjugates for Biomedical Applications.
abstract: Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled.
authors.affiliation: †Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 91120.|‡Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, 835215, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Basu
authors.affiliation: †Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 91120.
authors.forename: Konda Reddy
authors.initials: KR
authors.lastname: Kunduru
authors.affiliation: †Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 91120.
authors.forename: Ester
authors.initials: E
authors.lastname: Abtew
authors.affiliation: †Institute for Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel 91120.
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011134:Polysaccharides / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D011134:Polysaccharides