title: The efficacy of CT for detection of right ventricular dysfunction in acute pulmonary embolism, and comparison with cardiac biomarkers.
abstract: OBJECTIVE
  The purpose of this study was to evaluate results from computed tomography pulmonary angiography (CTPA) indicative of right ventricular dysfunction (RVD), and to assess the relationship of these results with cardiac biomarkers and mortality among patients with acute PE.
  
  
  METHODS
  This retrospective study involved 118 patients with acute PE proved by CTPA. CTPA variables were analyzed and compared with cardiac biomarkers and echocardiography (ECHO) findings.
  
  
  RESULTS
  Compared with ECHO, the sensitivity, specificity, positive predictive value, and negative predictive value of CTPA for detection of RVD were 85.7, 91.7, 93.7, and 81.5 %, respectively. ROC curve analysis for prediction of RVD resulted in areas under the curve of 0.925 for RV dimension (95 % CI 0.879-0.971, p < 0.001) and 0.913 for main pulmonary artery (MPA) diameter (95 % CI 0.863-0.963, p < 0.001). The optimum cut-off values for prediction of RVD were 37.5 mm for RV dimension and 29.1 mm for MPA diameter. These values were also statistically significantly greater for non-survivors than for survivors (p = 0.001, p < 0.001, respectively) and significantly associated with cardiac biomarkers.
  
  
  CONCLUSIONS
  It was found that CTPA findings were significantly associated with the presence of RVD in ECHO, cardiac biomarkers, and mortality of patients with acute PE.
authors.affiliation: Department of Chest Diseases, Faculty of Medicine, Firat University, 23119, Elazig, Turkey, inerda@gmail.com.
authors.forename: Erdal
authors.initials: E
authors.lastname: İn
authors.forename: Ayşe Murat
authors.initials: AM
authors.lastname: Aydın
authors.forename: Cengiz
authors.initials: C
authors.lastname: Özdemir
authors.forename: Sinem Nedime
authors.initials: SN
authors.lastname: Sökücü
authors.forename: Mustafa Necati
authors.initials: MN
authors.lastname: Dağlı
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins; D006801:Humans; D008297:Male; D008875:Middle Aged; D045283:Natriuretic Agents / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods*; D019210:Troponin I / Q000097:blood*; D018497:Ventricular Dysfunction, Right / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D045283:Natriuretic Agents; D019210:Troponin I; D020097:Natriuretic Peptide, Brain