title: Primary hepatic neuroendocrine tumor after 4 years tumor-free follow-up.
abstract: BACKGROUND
  A primary hepatic neuroendocrine tumour (PHNET) is a very rare disease. The liver represents the preferential site for neuroendocrine tumors' metastases.
  
  
  METHODS
  A 45-year old Caucasian female who presented with nausea, vomiting, diarrhea, accompanied by diffuse abdominal pain was found to have on contrast-enhanced computer tomography an encapsulated, partially cystic liver mass. The patient underwent an uneventful left atypical hepatic resection. Histopatological and immunohistochemical examination revealed a slowly growing (G1) hepatic neuroendocrine tumour. Post surgery, the specific neuroendocrine markers (serum Chromogranin A and 24h urinary 5 hydroxy-indolacetic acid) were within normal range. Further functional imaging investigations were performed. No other lesions were found making probable the diagnosis of PHNET. The patient is presently after 4 years of follow-up with no local recurrence or distant metastases.
  
  
  CONCLUSIONS
  The diagnosis of PHNET is a medical challenge that requires a thorough long term follow-up in order to exclude an occult primary neuroendocrine tumour.
authors.affiliation: Carol Davila University of Medicine and Pharmacy, PhD student, Bucharest, Romania.
authors.forename: Ioana Maria
authors.initials: IM
authors.lastname: Lambrescu
authors.affiliation: Endocrinology Department Elias University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Sorina
authors.initials: S
authors.lastname: Martin
authors.affiliation: Carol Davila University of Medicine and Pharmacy, PhD student, Bucharest, Romania.
authors.forename: Luminita
authors.initials: L
authors.lastname: Cima
authors.affiliation: Pathology Department, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Vlad
authors.initials: V
authors.lastname: Herlea
authors.affiliation: National Institute of Endocrinology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Corin
authors.initials: C
authors.lastname: Badiu
authors.affiliation: Endocrinology Department Elias University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Fica
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor