title: Autism Symptoms Across Adulthood in Men with Fragile X Syndrome: A Cross-Sectional Analysis.
abstract: A cross-sectional analysis was used to examine age-related differences in ASD symptoms and corresponding differences in disruptive behavior and social skills in 281 adult men with fragile X syndrome. Four age groups were created: 18-21, 22-29, 30-39, and 40-49 years. The 18-21 year-old group was reported to have more impairments in verbal communication than the 22-29 year-old group and more restricted and repetitive behaviors than the 40-49 year-old group. There was not an age-group difference in the percentage of men who met criteria for an ASD diagnosis based on respondent-reported, current symptoms. There was a trend for an age-related difference in disruptive behavior. Findings add to understanding of the developmental trajectory of ASD symptoms in adulthood.
authors.affiliation: Human Development and Family Studies and Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave., Madison, WI, 53705, USA. hartley@waisman.wisc.edu.
authors.forename: Sigan L
authors.initials: SL
authors.lastname: Hartley
authors.affiliation: RTI International, Research Triangle Park, NC, USA.
authors.forename: Anne C
authors.initials: AC
authors.lastname: Wheeler
authors.affiliation: Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Marsha R
authors.initials: MR
authors.lastname: Mailick
authors.affiliation: RTI International, Research Triangle Park, NC, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Raspa
authors.affiliation: Human Development and Family Studies, University of Wisconsin-Madison, Madison, WI, USA.
authors.forename: Iulia
authors.initials: I
authors.lastname: Mihaila
authors.affiliation: RTI International, Research Triangle Park, NC, USA.
authors.forename: Ellen
authors.initials: E
authors.lastname: Bishop
authors.affiliation: RTI International, Research Triangle Park, NC, USA.
authors.forename: Donald B
authors.initials: DB
authors.lastname: Bailey
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000523:psychology*; D000067877:Autism Spectrum Disorder / Q000150:complications* / Q000175:diagnosis / Q000523:psychology*; D003142:Communication; D003430:Cross-Sectional Studies; D005600:Fragile X Syndrome / Q000150:complications* / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000066553:Problem Behavior / Q000523:psychology; D066107:Social Skills; D055815:Young Adult
keywords: Adult; Aging; Autism; DSM; Fragile X syndrome