title: Coupled Simulation of Heart Valves: Applications to Clinical Practice.
abstract: The last few decades have seen great advances in the understanding of heart valves, and consequently, in the development of novel treatment modalities and surgical procedures for valves afflicted by disease. This is due in part to the profound advancements in computing technology and noninvasive medical imaging techniques that have made it possible to numerically model the complex heart valve systems characterized by distinct features at different length scales and various interacting processes. In this article, we highlight the importance of explicitly coupling these multiple scales and diverse processes to accurately simulate the true behavior of the heart valves, in health and disease. We examine some of the computational modeling studies that have a direct consequence on clinical practice.
authors.affiliation: Departments of Bioengineering and Mechanical Engineering, University of California, 208A Stanley Hall #1762, Berkeley, CA, 94720-1762, USA.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Bakhaty
authors.forename: Mohammad R K
authors.initials: MR
authors.lastname: Mofrad
mesh_terms: D003198:Computer Simulation; D006351:Heart Valves / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular