title: Optogenetic probing of mitochondrial damage responses.
abstract: It is now possible to functionally impair mitochondria through light illumination with high specificity. These optogenetic tools permit precise control on the timing, location, and extent of mitochondrial damage within a cell population with subcellular resolution, allowing quantitative probing of the various types of mitochondrial damage responses within cells. This approach can generally be extended toward the probing of other organelle damage responses.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.|Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei, Taiwan.
authors.forename: Wei Yuan
authors.initials: WY
authors.lastname: Yang
mesh_terms: D055011:Ablation Techniques; D000818:Animals; D001343:Autophagy; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*; D028361:Mitochondrial Diseases / Q000209:etiology*; D063306:Mitophagy; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects*; D062308:Optogenetics / Q000009:adverse effects; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*
keywords: Parkin; Parkinson disease; autophagy; mitochondria; mitophagy; optogenetics; photochemical control; photosensitizer; quality control