title: Increased cortico-striatal connectivity during motor practice contributes to the consolidation of motor memory in writer's cramp patients.
abstract: Sensorimotor representations of movements are created in the sensorimotor network through repeated practice to support successful and effortless performance. Writer's cramp (WC) is a disorder acquired through extensive practice of finger movements, and it is likely associated with the abnormal acquisition of sensorimotor representations. We investigated (i) the activation and connectivity changes in the brain network supporting the acquisition of sensorimotor representations of finger sequences in patients with WC and (ii) the link between these changes and consolidation of motor performance 24 h after the initial practice. Twenty-two patients with WC and 22 age-matched healthy volunteers practiced a complex sequence with the right (pathological) hand during functional MRI recording. Speed and accuracy were measured immediately before and after practice (day 1) and 24 h after practice (day 2). The two groups reached equivalent motor performance on day 1 and day 2. During motor practice, patients with WC had (i) reduced hippocampal activation and hippocampal-striatal functional connectivity; and (ii) overactivation of premotor-striatal areas, whose connectivity correlated with motor performance after consolidation. These results suggest that patients with WC use alternative networks to reach equiperformance in the acquisition of new motor memories.
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Centre de Neuroimagerie de Recherche, CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Gallea
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Centre de Neuroimagerie de Recherche, CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, France ; Laboratoire d'Imagerie NeuroFonctionnelle, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm U678, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Balas
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Centre de Neuroimagerie de Recherche, CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Bertasi
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Valabregue
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: García-Lorenzo
authors.affiliation: Laboratoire d'Imagerie NeuroFonctionnelle, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm U678, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Coynel
authors.affiliation: Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France ; Centre d'Investigation Clinique, Groupe Hospitalier Pitié-Salpêtrière, Paris, France ; Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonnet
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France ; Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Grabli
authors.affiliation: Laboratoire d'Imagerie NeuroFonctionnelle, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm U678, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Pélégrini-Issac
authors.affiliation: Unité de Neuroimagerie Fonctionnelle et Département de Psychologie, Université de Montréal, Québec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Doyon
authors.affiliation: Laboratoire d'Imagerie NeuroFonctionnelle, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm U678, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Benali
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France ; Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Roze
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France ; Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Vidailhet
authors.affiliation: Université Pierre et Marie Curie (UPMC Univ Paris 6), Institut du Cerveau et de la Moelle épinière - ICM, UMR-S975, Inserm, U975, CNRS, UMR 7225, Paris, France ; Centre de Neuroimagerie de Recherche, CENIR, Institut du Cerveau et de la Moelle épinière - ICM, Paris, France ; Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Lehericy
mesh_terms: D000328:Adult; D020821:Dystonic Disorders / Q000503:physiopathology*; D005260:Female; D005385:Fingers / Q000503:physiopathology; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D017072:Neostriatum / Q000503:physiopathology*; D011214:Practice, Psychological; D011597:Psychomotor Performance / Q000502:physiology*
keywords: BA, Brodmann area; CD, consolidation dependent; CV-RT, coefficient of variation for reaction time; DT1, dual task 1; DT2, dual task 2; FA, fractional anisotropy; FHD, focal hand dystonia; Focal dystonia; HV, healthy volunteers; Hippocampus; LD, longitudinal diffusivity; MRI; Motor cortex; PD, practice dependent; PMd, dorsal premotor cortex; PMv, ventral premotor cortex; PPI, psychophysiological interaction; RD, radial diffusivity; Striatum; WC, writer's cramp