title: Oral Sucrose for Pain in Neonates During Echocardiography: A Randomized Controlled Trial.
abstract: OBJECTIVE
  To test the efficacy of oral sucrose in reducing pain/stress during echocardiography as estimated by Premature Infant Pain Profile score.
  
  
  METHODS
  Double-blind, parallel-group, randomized control trial.
  
  
  METHODS
  Tertiary-care neonatal care unit located in Western India.
  
  
  METHODS
  Neonates with established enteral feeding, not on any respiratory support and with gestational age between 32 and 42 weeks requiring echocardiography.
  
  
  METHODS
  Neonates in intervention group received oral sucrose prior to echocardiography.
  
  
  METHODS
  Assessment was done using Premature Infant Pain Profile score.
  
  
  RESULTS
  There were 104 examinations; 52 in each group. Baseline characteristics like mean gestational age (37.6 vs. 37.1), birth weight (2.20 vs. 2.08), and feeding status (Breastfeeding- 59.6% vs. 44.2%, paladai feeding- 13.5% vs. 13.5%, and gavage feeding- 26.9% vs. 42.3%) were comparable. The mean (SD) premature infant pain profile score was significantly higher in control group [(7.4 (3.78) vs. 5.2 (1.92), P <0.001].
  
  
  CONCLUSIONS
  Oral sucrose significantly reduces pain, and is safe to administer to neonates.
authors.affiliation: Departments of Pediatrics and *Physiology, Pramukhswami Medical College; and #Central Research Services, Charutar Arogya Mandal; Karamsad, Gujarat, India. Correspondence to: Prof Somashekhar Nimbalkar, Professor of Pediatrics, Department of Pediatrics, Pramukhswami Medical College, Karamsad-Anand, Gujarat 388 325. somu_somu@yahoo.com.
authors.forename: Nirav T
authors.initials: NT
authors.lastname: Potana
authors.forename: Ashish R
authors.initials: AR
authors.lastname: Dongara
authors.forename: Somashekhar M
authors.initials: SM
authors.lastname: Nimbalkar
authors.forename: Dipen V
authors.initials: DV
authors.lastname: Patel
authors.forename: Archana S
authors.initials: AS
authors.lastname: Nimbalkar
authors.forename: Ajay
authors.initials: A
authors.lastname: Phatak
mesh_terms: D000284:Administration, Oral; D004452:Echocardiography / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007194:India; D007231:Infant, Newborn; D008297:Male; D010146:Pain / Q000188:drug therapy*; D059408:Pain Management / Q000379:methods*; D013395:Sucrose / Q000008:administration & dosage / Q000627:therapeutic use; D013549:Sweetening Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013549:Sweetening Agents; D013395:Sucrose