title: Quantitative Assessment of Mitral Apparatus Geometry Using Dual-Source Computed Tomography in Mitral Regurgitation.
abstract: To quantitatively assess the geometric changes in mitral valve apparatus in mitral regurgitation (MR) by dualsource computed tomography (DSCT) and to analyze its impact on MR.The study subjects consisted of 20 controls, 20 patients with mild MR, and 30 patients with moderate to severe MR, all of whom underwent DSCT. The geometric parameters of the mitral valve were measured by CT and compared among the 3 groups. The correlations between DSCT measurements and MR severity were also analyzed.As regurgitation worsened, our results showed progressive enlargements of the mitral annular area, anteroposterior diameter, and mitral valve tenting area at the central level. Moreover, a higher mitral valve sphericity index and longer distance between the heads of the papillary muscles reflected a more outward displacement of the papillary muscles. The mitral annular area and tenting area at the central level had strong correlations with regurgitation severity.DSCT is available to quantitatively assess mitral valve morphology and provide additional information regarding its geometry. The mitral annular area and tenting area at the central level were the strongest determinants of MR severity.
authors.affiliation: Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University.
authors.forename: Lingxuezi
authors.initials: L
authors.lastname: Zhang
authors.forename: Junwei
authors.initials: J
authors.lastname: Qiu
authors.forename: Linwei
authors.initials: L
authors.lastname: Yu
authors.forename: Sun
authors.initials: S
authors.lastname: Chen
authors.forename: Kun
authors.initials: K
authors.lastname: Sun
authors.forename: Liping
authors.initials: L
authors.lastname: Yao
mesh_terms: D000368:Aged; D061827:Dimensional Measurement Accuracy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology; D010210:Papillary Muscles / Q000000981:diagnostic imaging*; D011379:Prognosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013318:Stroke Volume; D014057:Tomography, X-Ray Computed; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology