title: Genome sequence of Bacillus anthracis attenuated vaccine strain A16R used for human in China.
abstract: An attenuated Bacillus anthracis vaccine strain for human use, A16R, was obtained in China after ultraviolet radiation treatment and continuous subculture of the wild-type strain A16. A16R can synthesize the exotoxin, but without a capsule. We sequenced and annotated the A16R genome to encourage the use of this strain. The genome sequencing of the wild-type strain A16 is underway and the genomic comparison between the two strains will help to illustrate the attenuating mechanism of the A16R vaccine strain.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Xiankai
authors.initials: X
authors.lastname: Liu
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Dongshu
authors.initials: D
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Deng
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Weili
authors.initials: W
authors.lastname: Wu
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; Beijing Genomics Institute, Beijing, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China.
authors.forename: Hengliang
authors.initials: H
authors.lastname: Wang
mesh_terms: D022122:Anthrax Vaccines / Q000235:genetics*; D001408:Bacillus anthracis / Q000235:genetics* / Q000528:radiation effects; D001482:Base Composition; D004269:DNA, Bacterial / Q000032:analysis; D016680:Genome, Bacterial / Q000528:radiation effects; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA / Q000379:methods*; D014613:Vaccines, Attenuated / Q000235:genetics
chemical_list: D022122:Anthrax Vaccines; D004269:DNA, Bacterial; D014613:Vaccines, Attenuated
keywords: Solexa; Vaccine strain