title: A switch-on MRI contrast agent for noninvasive visualization of methylmercury.
abstract: This communication presents the first Gd(III)-based T1 MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH3Hg(+). o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH3Hg(+). Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH3Hg(+). Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH3Hg(+) and could be useful for biomedical applications.
authors.affiliation: Department of Biological Science and Technology, Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 300, Taiwan. ymwang@mail.nctu.edu.tw.
authors.forename: Gyan
authors.initials: G
authors.lastname: Singh
authors.forename: Kuang-Mei
authors.initials: KM
authors.lastname: Hsu
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Chen
authors.forename: Shou-Cheng
authors.initials: SC
authors.lastname: Wu
authors.forename: Chiao-Yun
authors.initials: CY
authors.lastname: Chen
authors.forename: Yun-Ming
authors.initials: YM
authors.lastname: Wang
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D005682:Gadolinium / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000737:chemistry; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008767:Methylmercury Compounds / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D009498:Neurotoxins / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics
chemical_list: D003287:Contrast Media; D004785:Environmental Pollutants; D008767:Methylmercury Compounds; D009498:Neurotoxins; D005682:Gadolinium