title: Placental and fetal cysteine dioxygenase gene expression in mouse gestation.
abstract: Nutrient sulfate is important for fetal development. The fetus has a limited capacity to generate sulfate and relies on maternal sulfate supplied via the placenta. The gestational age when fetal sulfate generation begins is unknown but would require cysteine dioxygenase (CDO1) which mediates a major step of sulfate production from cysteine. We investigated the ontogeny of Cdo1 mRNA expression in mouse fetal and placental tissues, which showed increasing levels from embryonic day 10.5 and was localised to the decidua and several fetal tissues including nasal cavities and brain. These findings suggest a role for Cdo1 in sulfate generation from mid-gestation.
authors.affiliation: Mater Research Institute, University of Queensland, Woolloongabba, Australia; School of Biomedical Sciences, University of Queensland, St. Lucia, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Rakoczy
authors.affiliation: Mater Research Institute, University of Queensland, Woolloongabba, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.affiliation: Mater Research Institute, University of Queensland, Woolloongabba, Australia.
authors.forename: S J
authors.initials: SJ
authors.lastname: Weerasekera
authors.affiliation: School of Biomedical Sciences, University of Queensland, St. Lucia, Australia.
authors.forename: D G
authors.initials: DG
authors.lastname: Simmons
authors.affiliation: Mater Research Institute, University of Queensland, Woolloongabba, Australia; School of Biomedical Sciences, University of Queensland, St. Lucia, Australia. Electronic address: paul.dawson@mater.uq.edu.au.
authors.forename: P A
authors.initials: PA
authors.lastname: Dawson
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D050558:Cysteine Dioxygenase / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D015870:Gene Expression; D051379:Mice; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D050558:Cysteine Dioxygenase
keywords: Cysteine dioxygenase; Decidua; Fetus; Placenta; Pregnancy; Sulfate