title: Recent strategies and progress in identifying host factors involved in virus replication.
abstract: Viruses are completely dependent on their host cells for the successful production of progeny viruses. At each stage of the viral life cycle an intricate interplay between virus and host takes place with the virus aiming to usurp the host cell for its purposes and the host cell trying to block the intruder from propagation. In recent years these interactions have been studied on a global level by systems biology approaches, such as RNA interference screens, transcriptomic or proteomic methodologies, and exciting new insights into the pathogen-host relationship have been revealed. In this review, we summarize the available data, give examples for important findings from such studies and point out current limitations and potential future directions.
authors.affiliation: Research Group "Host-Pathogen Interactions", Paul-Ehrlich-Institute, 63225 Langen, Germany; Infectious & Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA; German Center for Infection Research (DZIF), Langen, Germany. Electronic address: Renate.Koenig@pei.de.
authors.forename: Renate
authors.initials: R
authors.lastname: König
authors.affiliation: Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland. Electronic address: stertz.silke@virology.uzh.ch.
authors.forename: Silke
authors.initials: S
authors.lastname: Stertz
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D006801:Humans; D020543:Proteome / Q000032:analysis; D049490:Systems Biology; D014779:Virus Replication; D014780:Viruses / Q000254:growth & development* / Q000276:immunology*
chemical_list: D020543:Proteome