title: Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively.
abstract: We retrospectively analyzed the findings of a prospective cohort of 75 children referred for thyroid nodules between 2008 and 2013. Prevalence of papillary differentiated thyroid carcinoma was 18.7%. Thyrotropin >2.5 mIU/L, multinodular goiter, solid nodules, irregular margins, and pathologic lymphadenopathies were identified as independent predictors of malignancy.
authors.affiliation: Centro de Investigaciones Endocrinológicas Dr. César Bergadá, Consejo Nacional de Investigaciones Científicas y Técnicas, Division of Endocrinology, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina. Electronic address: patopapen@yahoo.com.ar.
authors.forename: Patricia
authors.initials: P
authors.lastname: Papendieck
authors.affiliation: Centro de Investigaciones Endocrinológicas Dr. César Bergadá, Consejo Nacional de Investigaciones Científicas y Técnicas, Division of Endocrinology, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Gruñeiro-Papendieck
authors.affiliation: Centro de Investigaciones Endocrinológicas Dr. César Bergadá, Consejo Nacional de Investigaciones Científicas y Técnicas, Division of Endocrinology, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Marcela
authors.initials: M
authors.lastname: Venara
authors.affiliation: Surgery Department, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Oscar
authors.initials: O
authors.lastname: Acha
authors.affiliation: Radiology Department, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Hugo
authors.initials: H
authors.lastname: Cozzani
authors.affiliation: Radiology Department, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Mateos
authors.affiliation: Pathological Anatomy Department, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Silvana
authors.initials: S
authors.lastname: Maglio
authors.affiliation: School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
authors.forename: Maria Lujan
authors.initials: ML
authors.lastname: Calcagno
authors.affiliation: Centro de Investigaciones Endocrinológicas Dr. César Bergadá, Consejo Nacional de Investigaciones Científicas y Técnicas, Division of Endocrinology, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Bergada
authors.affiliation: Centro de Investigaciones Endocrinológicas Dr. César Bergadá, Consejo Nacional de Investigaciones Científicas y Técnicas, Division of Endocrinology, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
authors.forename: Ana
authors.initials: A
authors.lastname: Chiesa
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D000293:Adolescent; D044963:Biopsy, Fine-Needle; D002291:Carcinoma, Papillary / Q000175:diagnosis; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D016606:Thyroid Nodule / Q000473:pathology*; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D013972:Thyrotropin