title: Multivariate Analysis of Prognostic Biomarkers in Surgically Treated Endometrial Cancer.
abstract: OBJECTIVE
  The aim of this study was to identify biomarkers with prognostic value in the setting of surgically treated endometrial cancer.
  
  
  METHODS
  Medical data for 282 patients with surgically treated endometrial cancer were reviewed retrospectively. Preoperative concentrations of six serum biomarkers (CA125, CA15-3, C-reactive protein [CRP], D-dimer [D-D], platelet-to-lymphocyte ratio [PLR], and neutrophil-to-lymphocyte ratio [NLR]) were analysed to determine potential associations with clinicopathologic characteristics and to assess prognostic values separately via Kaplan-Meier method and multivariate Cox regression.
  
  
  RESULTS
  In univariate analyses, the 5-year overall survival (OS) rate was 86.5% for a maximum follow-up period of 75 months. High concentrations of CA125, CA15-3, CRP, D-D, PLR, and NLR each proved significantly predictive of poor survival (log-rank test, P<0.01). CRP and D-D were identified as independent prognosticators, using a Cox regression model. Study patients were then stratified (based on combined independent risk factors) into three tiers (P<0.001), marked by 5-year OS rates of 92.1%, 78.4%, and 33.3%.
  
  
  CONCLUSIONS
  All serum biomarkers assessed (CA125, CA15-3, CRP, D-D, PLR, and NLR) proved to be valid prognostic indices of surgically treated endometrial cancer. A novel prognostic grouping system, incorporating independent risk factors (CRP and D-D Concentrations), may have merit in assessing these patients preoperatively, providing a biologic basis for improved clinical staging.
authors.affiliation: Department of Clinical laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong province, PR China.
authors.forename: Jianpei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Clinical laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong province, PR China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Clinical laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong province, PR China.
authors.forename: Yaoling
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Clinical laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong province, PR China.
authors.forename: Miaohuan
authors.initials: M
authors.lastname: Kuang
authors.affiliation: Department of Clinical laboratory, State Key Laboratory of Oncology in South China/Cancer Center of Sun Yat-sen University, Guangzhou, Guangdong province, PR China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D001792:Blood Platelets / Q000473:pathology; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism; D018394:CA-125 Antigen / Q000097:blood / Q000235:genetics; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000601:surgery*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood / Q000235:genetics; D015999:Multivariate Analysis; D009504:Neutrophils / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D005338:Fibrin Fibrinogen Degradation Products; C451759:MUC16 protein, human; D008565:Membrane Proteins; D018396:Mucin-1; C036309:fibrin fragment D; D002097:C-Reactive Protein