title: A feasibility study for using ABS plastic and a low-cost 3D printer for patient-specific brachytherapy mould design.
abstract: This feasibility study aims to determine if a low-cost 3D printer (BitsFromBytes 3D Touch) with ABS plastic can print custom mould structures and catheter channels defined in a brachytherapy treatment planning system (Nucletron Oncentra) for patient-specific treatment. Printer accuracy was evaluated through physical measurement, and print quality was investigated by adjusting print parameters (print speed, layer thickness, percentage infill). Catheter positioning and reproducibility were measured over repeated insertions. ABS plastic water equivalency was investigated by comparing Ir-192 HDR source dose distributions, measured with radiochromic film, in ABS plastic and in water. Structures and catheter channels were printed accurately to within 0.5 mm laterally and 1 mm in the vertical print direction. Adjusting print parameters could reduce print time, albeit with reduced print quality. 3.5 mm channel diameters allowed for easy catheter insertion. Catheter positioning was reproducible to within 0.5 mm but, because of catheter flex within the channel, was on average 1 mm offset from defined TPS positions. This offset could be accounted for by repeating the treatment planning CT scan with the printed mould positioned on the patient. Dose attenuation in ABS plastic and in water was equivalent to within the measurement limitations. While clinical uses for this particular low-cost printer and ABS plastic are limited by print size restrictions and non-certification for biocompatibility, it has been demonstrated that a low-cost 3D printer set-up can accurately create custom moulds and catheter channels potentially acceptable for clinical use.
authors.affiliation: Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, 4102, Australia. bdharris.1988@gmail.com.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Harris
authors.affiliation: Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, 4029, Australia.
authors.forename: Sanna
authors.initials: S
authors.lastname: Nilsson
authors.affiliation: Department of Obstetrics & Gynaecology, University of Melbourne, Royal Women's Hospital, Melbourne, VIC, 3052, Australia.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Poole
mesh_terms: D000180:Acrylic Resins / Q000627:therapeutic use*; D001918:Brachytherapy / Q000295:instrumentation*; D002070:Butadienes / Q000627:therapeutic use*; D005240:Feasibility Studies; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D008954:Models, Biological; D019047:Phantoms, Imaging; D010969:Plastics / Q000627:therapeutic use*; D011137:Polystyrenes / Q000627:therapeutic use*; D057285:Precision Medicine / Q000295:instrumentation*; D066330:Printing, Three-Dimensional / Q000295:instrumentation*; D014057:Tomography, X-Ray Computed
chemical_list: D000180:Acrylic Resins; D002070:Butadienes; D010969:Plastics; D011137:Polystyrenes; C024636:ABS resin
keywords: 3D printing; Brachytherapy; Customised moulds; Patient-specific treatment