title: PP083. Clinic and out-of-clinic blood pressure changes during pregnancy by parity: Boshi study.
abstract: BACKGROUND
  Nulliparity is believed to be one of the risk factors for hypertension during pregnancy. However, the relationship between parity and out-of-clinic blood pressure during pregnancy is still unknown.
  
  
  OBJECTIVE
  The aim of this study was to evaluate clinic blood pressure and blood pressure measured at home during pregnancy among nulliparous and multiparous women.
  
  
  METHODS
  This study was a prospective cohort study. We examined blood pressure measured in the clinic and at home among 530 normotensive pregnant women who received antenatal care at a maternity hospital in Japan. Clinic blood pressures were obtained by duplicate measurements at each antenatal care visit. The participants were also required to measure their own blood pressures every morning at home while they were pregnant. A linear mixed model was used for analysis of the blood pressure course throughout pregnancy [1]. The SAS package (version 9.2) was used for the statistical analyses.
  
  
  RESULTS
  A total of 315 nulliparous and 215 multiparous women were entered into this study (mean ages 30.1±4.6years and 33.0±4.1years, respectively). Clinic blood pressure during pregnancy among nulliparous women was significantly higher than that among multiparous women (P=0.02/P<0.0001 for systolic/diastolic blood pressure), whereas there were no significant differences in blood pressure measured at home during pregnancy between them (P=0.42/P=0.22 for systolic/diastolic blood pressure).
  
  
  CONCLUSIONS
  Out-of-clinic blood pressure levels during pregnancy have been shown not to differ between nulliparous and multiparous women, while clinic blood pressure during pregnancy among nulliparous women is higher than that among multiparous women.
authors.affiliation: Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ishikuro
authors.affiliation: Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Obara
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Metoki
authors.affiliation: Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan; Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohkubo
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Akutsu
authors.affiliation: Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakurai
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Iwama
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katagiri
authors.affiliation: Suzuki Memorial Hospital, Iwanuma, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yagihashi
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yaegashi
authors.affiliation: Suzuki Memorial Hospital, Iwanuma, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.affiliation: Suzuki Memorial Hospital, Iwanuma, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kuriyama
authors.affiliation: Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Imai