title: Does the adhesive strategy influence the post-operative sensitivity in adult patients with posterior resin composite restorations?: A systematic review and meta-analysis.
abstract: OBJECTIVE
  A systematic review and meta-analysis were performed on the risk and intensity of postoperative sensitivity (POS) in posterior resin composite restorations bonded with self-etch (SE) and etch-and-rinse (ER) adhesives.
  
  
  METHODS
  A comprehensive search was performed in the MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE without restrictions. The abstracts of the annual conference of the IADR (1990-2014), unpublished and ongoing trials registry were also searched. Dissertations and theses were searched using the ProQuest Dissertations and Periodicos Capes Theses databases.
  
  
  METHODS
  We included randomized clinical trials that compared the clinical effectiveness of SE and ER used for direct resin composite restorations in permanent dentition of adult patients. The risk/intensity of POS was the primary outcome. The risk of bias tool of the Cochrane Collaboration was used. The meta-analysis was performed on the studies considered 'low' risk of bias.
  
  
  METHODS
  After duplicates removal, 2600 articles were identified but only 29 remained in the qualitative synthesis. Five were considered to be 'high' risk of bias and eleven were considered to be 'unclear' in the key domains, yielding 13 studies for meta-analysis. The overall relative risk of the spontaneous POS was 0.63 (95% CI 0.35 to 1.15), while the stimuli-induced POS was 0.99 (95% CI 0.63 to 1.56). The overall standardized mean difference was 0.08 (95%CI -0.19 to 0.35). No overall effect was revealed in the meta-analyses, meaning that no influence of the ER or SE strategy on POS.
  
  
  CONCLUSIONS
  The type of adhesive strategy (ER or SE) for posterior resin composite restorations does not influence the risk and intensity of POS. CRD42014006617.
authors.affiliation: Department of Restorative Dentistry, State University of Ponta Grossa, Rua Carlos Cavalcanti, 4748-Uvaranas, Ponta Grossa, PR, CEP 84030-900, Brazil. Electronic address: reis_ale@hotmail.com.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Reis
authors.affiliation: Department of Restorative Dentistry, State University of Ponta Grossa, Rua Carlos Cavalcanti, 4748-Uvaranas, Ponta Grossa, PR, CEP 84030-900, Brazil.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Dourado Loguercio
authors.affiliation: Department of Dental Materials, Federal University of Rio de Janeiro, School of Dentistry, Cidade Universitária, RJ, CEP 21941-971, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Schroeder
authors.affiliation: Department of Restorative Dentistry, State University of Ponta Grossa, Rua Carlos Cavalcanti, 4748-Uvaranas, Ponta Grossa, PR, CEP 84030-900, Brazil.
authors.forename: Issis
authors.initials: I
authors.lastname: Luque-Martinez
authors.affiliation: Federal Universityof Rio de Janeiro. Library. Cidade Universitária, RJ, CEP 21941-971, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Masterson
authors.affiliation: Department of Orthodontic and Pediatric Dentistry, Federal University of Rio de Janeiro, Departament of Pediatric Dentistry, 68066-Cidade Universitária, RJ, CEP 21941-971, Brazil.
authors.forename: Lucianne
authors.initials: L
authors.lastname: Cople Maia
mesh_terms: D000328:Adult; D000818:Animals; D003188:Composite Resins / Q000627:therapeutic use*; D003731:Dental Caries / Q000150:complications / Q000628:therapy*; D003793:Dental Restoration, Permanent; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D017220:Dentin-Bonding Agents / Q000627:therapeutic use; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic
chemical_list: D003188:Composite Resins; D017220:Dentin-Bonding Agents
keywords: Adhesive system; Posterior restoration; Postoperative sensitivity; Randomized clinical trials; Systematic review