title: Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012.
abstract: OBJECTIVE
  To analyze the prevalence, length and predictors of hospitalization in the biological era in the population-based inception cohort from Veszprem province.
  
  
  METHODS
  Data of 331 incident Crohn's disease (CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed (median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.
  
  
  RESULTS
  Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%, 53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures (37%), surgery or disease activity (27% and 21%). Non-inflammatory disease behavior at diagnosis (HR = 1.32, P = 0.001) and perianal disease (HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change (HR = 2.38, P = 0.002) and need for steroids (HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses. Early CD-related hospitalization (within the year of diagnosis) was independently associated with need for immunosuppressives (OR = 2.08, P = 0.001) and need for surgeries (OR = 7.25, P < 0.001) during the disease course.
  
  
  CONCLUSIONS
  Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and re-hospitalization.
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Petra A
authors.initials: PA
authors.lastname: Golovics
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Laszlo
authors.initials: L
authors.lastname: Lakatos
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mandel
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Lovasz
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Vegh
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kurti
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Istvan
authors.initials: I
authors.lastname: Szita
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Lajos S
authors.initials: LS
authors.lastname: Kiss
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Tunde
authors.initials: T
authors.lastname: Pandur
authors.affiliation: Petra A Golovics, Michael D Mandel, Barbara D Lovasz, Zsuzsanna Vegh, Zsuzsanna Kurti, Lajos S Kiss, Peter L Lakatos, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary.
authors.forename: Peter L
authors.initials: PL
authors.lastname: Lakatos
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*; D013505:Digestive System Surgical Procedures; D005260:Female; D006760:Hospitalization; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053208:Kaplan-Meier Estimate; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010359:Patient Readmission; D011159:Population Surveillance; D015995:Prevalence; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: Biological therapy; Crohn’s disease; Hospitalization; Population-based; Predictor; Recurrence