title: A single rapid point-of-care placental growth factor determination as an aid in the diagnosis of preeclampsia.
abstract: OBJECTIVE
  To evaluate the clinical performance of a rapid point-of-care test, Triage PLGF (Alere, San Diego) in the diagnosis of preeclampsia.
  
  
  METHODS
  For the reference range 2212 plasma samples were collected from 595 subjects with normotensive pregnancies, between week 17 of gestation and delivery. In the case-control part, two cohorts of women with preeclampsia (80 women) were matched for maternal age, gestational age (GA) at sampling and parity with normotensive women who delivered at 37weeks or more.
  
  
  RESULTS
  The areas under the receiver operating characteristic curves (GA<35weeks) were 1.0 and 0.994 (cohort 1 and 2, respectively). The clinical sensitivity of the Triage PLGF test for the pooled GA range of 21⩽GA<35, using a GA dependent cut-off, was 1.0 for both cohorts with specificities of 1.0 and 0.940.
  
  
  CONCLUSIONS
  The Triage PLGF test distinguishes well between preterm pregnancies with and without preeclampsia.
authors.affiliation: Department of Obstetrics and Gynaecology, Randers Hospital, Denmark. Electronic address: ubk@dadlnet.dk.
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Knudsen
authors.affiliation: Department of Obstetrics and Gynaecology, Randers Hospital, Denmark.
authors.forename: Camilla S
authors.initials: CS
authors.lastname: Kronborg
authors.affiliation: Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: von Dadelszen
authors.affiliation: Alere, San Diego, CA, United States.
authors.forename: Ken
authors.initials: K
authors.lastname: Kupfer
authors.affiliation: Alere, San Diego, CA, United States.
authors.forename: Seok-Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynaecology, Randers Hospital, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Vittinghus
authors.affiliation: Department of Obstetrics and Gynaecology, Randers Hospital, Denmark.
authors.forename: Jim G
authors.initials: JG
authors.lastname: Allen
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Redman
keywords: Angiogenesis; Biomarkers; PlGF; Preeclampsia; Preterm preeclampsia; Triage PLGF test