title: Vascular Calcification Progression Is an Independent Predictor of Mortality in Patients on Haemodialysis.
abstract: BACKGROUND
  We previously reported that vascular calcification (VC) score was associated with mortality in patients on haemodialysis (HD) and that a high serum level of parathyroid hormone (PTH) and fibroblast growth factor (FGF)-23 were the only factors associated with VC progression.
  
  
  OBJECTIVE
  To assess the impact of VC progression on HD patient survival.
  
  
  METHODS
  The study cohort including 85 HD patients studied between 2006 and 2007 and between 2009 and 2010 was divided into patients with VC progression (PG+, n = 38) and no-progression (PG-, n = 47), based on VC scores measured twice at 3-year intervals (VC1 and VC2). Patients were followed during 3 additional years.
  
  
  RESULTS
  Kaplan-Meier analysis determined that PG+ displayed increased mortality (hazard ratio (HR): 2.4; 95% confidence interval (CI): 1.12-4.8; p = 0.03). This result was confirmed using a Cox proportional hazards model adjusted for age, dialysis duration, the VC1 score, and the mean FGF-23 and iPTH serum levels (HR: 2.7; 95% CI: 1.12-6.6; p = 0.02).
  
  
  CONCLUSIONS
  VC progression is associated with poor survival in patients on HD, irrespective of a patient's baseline VC score.
authors.affiliation: NephroCare Tassin-Charcot, Sainte Foy-Les-Lyon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Jean
authors.forename: Brice
authors.initials: B
authors.lastname: Mayor
authors.forename: Patrik
authors.initials: P
authors.lastname: Deleaval
authors.forename: Christie
authors.initials: C
authors.lastname: Lorriaux
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Hurot
authors.forename: Eric
authors.initials: E
authors.lastname: Bresson
authors.forename: Charles
authors.initials: C
authors.lastname: Chazot
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000150:complications / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis / Q000401:mortality*; D016019:Survival Analysis; D061205:Vascular Calcification / Q000209:etiology / Q000401:mortality*
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23