title: Facial expression perception correlates with verbal working memory function in schizophrenia.
abstract: OBJECTIVE
  Facial emotion perception is considered to provide a measure of social cognition. Numerous studies have examined the perception of emotion in patients with schizophrenia, and the majority has reported impaired ability to recognize facial emotion perception. We aimed to investigate the correlation between facial expression recognition and other domains of social cognition and neurocognition in Japanese patients with schizophrenia.
  
  
  METHODS
  Participants were 52 patients with schizophrenia and 53 normal controls with no history of psychiatric diseases. All participants completed the Hinting Task and the Social Cognition Screening Questionnaire. The Brief Assessment of Cognition in Schizophrenia was administered only to the patients. Facial emotion perception measured by the Facial Emotion Selection Test (FEST) was compared between the patients and normal controls.
  
  
  RESULTS
  Patients performed significantly worse on the FEST compared to normal control subjects. The FEST total score was significantly positively correlated with scores of the Brief Assessment of Cognition in Schizophrenia attention subscale, Hinting Task, Social Cognition Screening Questionnaire Verbal Working Memory and Metacognition subscales. Stepwise multiple regression analysis revealed that verbal working memory function was positively related to the facial emotion perception ability in patients with schizophrenia.
  
  
  CONCLUSIONS
  These results point to the concept that facial emotion perception and some types of working memory use common cognitive resources. Our findings may provide implications for cognitive rehabilitation and related interventions in schizophrenia.
authors.affiliation: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.|Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hagiya
authors.affiliation: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Tomiki
authors.initials: T
authors.lastname: Sumiyoshi
authors.affiliation: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Ayako
authors.identifier: http://orcid.org/0000-0001-8480-7001
authors.initials: A
authors.lastname: Kanie
authors.affiliation: Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, Tottori, Japan.
authors.forename: Shenghong
authors.initials: S
authors.lastname: Pu
authors.affiliation: Division of Neuropsychiatry, Department of Brain and Neuroscience, Tottori University Faculty of Medicine, Tottori, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaneko
authors.affiliation: Department of Clinical Psychology, Graduate School of Medical Sciences, Tottori University, Tottori, Japan.
authors.forename: Tamiko
authors.initials: T
authors.lastname: Mogami
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Sachie
authors.initials: S
authors.lastname: Oshima
authors.affiliation: Department of Neuropsychiatry, Fukushima Medical University, Fukushima, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Niwa
authors.affiliation: Department of Psychiatric Nursing, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.|Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Inagaki
authors.affiliation: Department of Neuropsychiatry, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Ikebuchi
authors.affiliation: Department of Forensic Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Kikuchi
authors.affiliation: Department of Psychiatry & Behavioral Science, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
authors.forename: Syudo
authors.initials: S
authors.lastname: Yamasaki
authors.affiliation: Department of Psychiatry, Osaka Psychiatric Medical Center, Osaka, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwata
authors.affiliation: Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nakagome
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005149:Facial Expression; D000066499:Facial Recognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D000067489:Metacognition; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012938:Social Perception; D056345:Theory of Mind; D014706:Verbal Learning
keywords: facial emotion perception; neurocognition; schizophrenia; social cognition; working memory