title: Peptic ulcer hemorrhage combined with acute gout: analyses of treatment in 136 cases.
abstract: This study aims to compare the safety and curative effect of celecoxib and small-dose methylprednisolone sodium succinate in patients with peptic ulcer hemorrhage combined with acute gout. In this randomized, controlled trial, a total of 136 patients with peptic ulcer hemorrhage combined with acute gout were divided into the celecoxib group or the small-dose methylprednisolone sodium succinate group. These patients underwent gastroscopy hemostasis and proton pump inhibitor (PPI) therapy. Moreover, for the treatment of gout, the patients were administered either celecoxib or small-dose methylprednisolone sodium succinate. Adverse reactions and the visual analogue scale (VAS) score were recorded for the two groups. The difference in adverse reactions between the two groups was not significant (χ(2) = 0.002, P = 0.967). The duration of evident pain relief after the first dose of treatment showed a significant difference between the two groups (t = 13.728, P < 0.01). The VAS scores before treatment were not significantly different between the two groups (t = -1.786, P = 0.076). The VAS scores at 6 h, 2 days, 4 days, 6 days, and 8 days after treatment were significantly different between the two groups (t = 3.239, 6.586, 6.280, 3.737, 3.215; P = 0.002, 0.000, 0.000, 0.000, 0.002, respectively). In cases that receive effective gastroscopy hemostasis and PPI therapy, small-dose methylprednisolone sodium succinate exhibits a greater clinical curative effect for peptic ulcer hemorrhage combined with acute gout as compared to celecoxib, and is associated with greater safety.
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Zhenglei
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Dingguo
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Ruiyue
authors.initials: R
authors.lastname: Shi
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Gastroenterology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital Shenzhen 518000, Guangdong Province, China.
authors.forename: Lisheng
authors.initials: L
authors.lastname: Wang
keywords: Peptic ulcer; acute gout; hemorrhage