title: Relation of Serum and Vitreous Concentrations of Fetuin-A with Diabetic Retinopathy.
abstract: BACKGROUND
  Fetuin-A, a liver-derived glycoprotein, is correlated with diabetes. The aim of the present investigation was to evaluate serum and vitreous concentrations of fetuin-A in patients with diabetic retinopathy (DR).
  
  
  METHODS
  We randomly selected 224 diabetic patients and 68 control subjects for this study. RESULTS :There were markedly higher serum and vitreous fetuin-A concentrations in proliferative diabetic retinopathy (PDR) patients than in the other three groups. NPDR patients exhibited elevated vitreous fetuin-A concentrations compared with patients without DR. However, no significant differences in serum fetuin-A concentrations were observed between NPDR patients and patients without DR. In addition, there were significantly lower concentrations of serum and vitreous fetuin-A in control subjects compared with the other three groups.
  
  
  CONCLUSIONS
  The occurrence and severity of DR is correlated with serum and vitreous fetuin-A concentrations.
authors.affiliation: Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Chunming
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Jiangping
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Oncology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Shengxi
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Oncology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland).
authors.forename: Rui
authors.initials: R
authors.lastname: Jiang
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism*; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D060749:alpha-2-HS-Glycoprotein