title: Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues.
abstract: OBJECTIVE
  To analyze the clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues.
  
  
  METHODS
  One hundred and eight tissue samples from the patients with endometrial cancer enrolled in our hospital from August 2011 to July 2014 were selected, including 60 normal tissue samples (normal group), 60 neoplastic tissue samples (neoplastic group) and 60 cancer tissue samples (cancer group). All the samples were subjected to immunohistochemical assay to detect the expressions of COX-2, GLUT-1 and VEGF. The clinical data were also investigated for correlation analysis.
  
  
  RESULTS
  The positive rates of COX-2 in normal group, neoplastic group and cancer groups were 3.3%, 21.7% and 55.0% respectively. The positive rates of GLUT-1 in normal group, neoplastic group and cancer groups were 3.3%, 25.0% and 70.0% respectively. The positive rates of VEGF in normal group, neoplastic group and cancer groups were 1.7%, 23.3% and 63.3% respectively. With increasing stage of such cancer, decreasing degree of differentiation and lymphatic metastasis, the positive expression rates of COX-2, GLUT-1 and VEGF proteins were raised significantly (P<0.05). Spearman's correlation analysis showed that the expressions of COX-2 and GLUT-1 (r=0.207, P<0.05), COX-2 and VEGF (r=0.243, P<0.05), as well as GLUT-1 and VEGF (r=0.758, P<0.05) were positively correlated.
  
  
  CONCLUSIONS
  COX-2, GLUT-1 and VEGF were highly prominent in endometrial cancer, especially in the patients with low degree of differentiation, late stage and metastasis. They functioned synergistically in the onset and progression of this cancer.
authors.affiliation: Xiaoping Ma, Department of Gynecology and Obstetrics, Qilu Hospital Affiliated to Shandong University, Jinan 250012, Shandong Province, P.R. China. Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Ma
authors.affiliation: Yuzuo Hui, Department of Neurosurgery, Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Yuzuo
authors.initials: Y
authors.lastname: Hui
authors.affiliation: Li Lin, Department of Gynecology and Obstetrics, Qilu Hospital Affiliated to Shandong University, Jinan 250012, Shandong Province, P.R. China. Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Yu Wu, Department of Gynecology and Obstetrics, Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Xian Zhang, Department of Gynecology and Obstetrics, Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Xian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Peishu Liu, Department of Gynecology and Obstetrics, Qilu Hospital Affiliated to Shandong University, Jinan 250012, Shandong Province, P.R. China. Liaocheng People's Hospital and Clinical Teaching Hospital, Taishan Medical College, Liaocheng 252000, Shandong Province, P.R. China.
authors.forename: Peishu
authors.initials: P
authors.lastname: Liu
keywords: COX-2; Endometrial cancer; GLUT-1; VEGF