title: Autologous hematopoietic stem cell transplantation in elderly patients (≥ 70 years) with non-Hodgkin's lymphoma: A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study.
abstract: BACKGROUND
  Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL).
  
  
  METHODS
  In the setting of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) group, we retrospectively analyzed 81 consecutive patients with NHL over 70 years of age who received AHSCT.
  
  
  RESULTS
  The median age at AHSCT was 72.3 years [70-80]. Patients' were diagnosed with diffuse large B-cell lymphoma (n=40), follicular lymphoma (n=16), mantle cell lymphoma (n=15), T-cell lymphoma (n=5), and other (n=5). Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) was 0 in 73% of patients. Main conditionings were BEAM (Carmustine-Etoposide-Cytarabine-Melphalan, n=61) and melphalan alone (n=14). Median delays to reach 0.5×10⁹/L neutrophils and 20 × 10(9)/L platelets were of 12 [9-76] days and 12 [0-143] days, respectively. One hundred day and one year cumulative incidence of NRM was 5.4% and 8.5%, respectively. The main cause of death remains relapse.
  
  
  CONCLUSIONS
  In conclusion, this study revealed that AHSCT seemed to be acceptable in patients over 70 years of age with NHL. Patient age is not a limiting factor if clinical condition is adequate.
authors.affiliation: Service de thérapie cellulaire et d'hématologie clinique adulte, Université d'Auvergne EA3846, CIC-501, CHU Clermont-Ferrand Hôpital Estaing, Clermont-Ferrand, France. Electronic address: ehermet@chu-clermontferrand.fr.
authors.forename: E
authors.initials: E
authors.lastname: Hermet
authors.affiliation: Service de thérapie cellulaire et d'hématologie clinique adulte, Université d'Auvergne EA3846, CIC-501, CHU Clermont-Ferrand Hôpital Estaing, Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Cabrespine
authors.affiliation: Service de thérapie cellulaire et d'hématologie clinique adulte, Université d'Auvergne EA3846, CIC-501, CHU Clermont-Ferrand Hôpital Estaing, Clermont-Ferrand, France.
authors.forename: R
authors.initials: R
authors.lastname: Guièze
authors.affiliation: Hôpital Pitié-Salpétrière, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Garnier
authors.affiliation: Hôpital Augustin Morvan, Brest, France.
authors.forename: A
authors.initials: A
authors.lastname: Tempescul
authors.affiliation: Centre Henri Becquerel, Rouen, France.
authors.forename: P
authors.initials: P
authors.lastname: Lenain
authors.affiliation: Institut Paoli Calmettes, Marseille, France.
authors.forename: R
authors.initials: R
authors.lastname: Bouabdallah
authors.affiliation: Centre François Baclesse, Caen, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Vilque
authors.affiliation: Centre Hospitalier de Meaux, Meaux, France.
authors.forename: J
authors.initials: J
authors.lastname: Frayfer
authors.affiliation: Hôpital Universitaire Dupuytren, Limoges, France.
authors.forename: D
authors.initials: D
authors.lastname: Bordessoule
authors.affiliation: Hôpital Saint-Louis, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Sibon
authors.affiliation: Centre René Huguelin, St Cloud, France.
authors.forename: M
authors.initials: M
authors.lastname: Janvier
authors.affiliation: Hôpital Le Bocage, Dijon, France.
authors.forename: D
authors.initials: D
authors.lastname: Caillot
authors.affiliation: Centre Leon Berard, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Biron
authors.affiliation: Hôpital l'Archet, Nice, France.
authors.forename: L
authors.initials: L
authors.lastname: Legros
authors.affiliation: Hôpital Duchenne, Boulogne/mer, France.
authors.forename: B
authors.initials: B
authors.lastname: Choufi
authors.affiliation: Hôpital Emile Muller, Mulhouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Drenou
authors.affiliation: Hôpital St-Antoine, Paris, France.
authors.forename: N C
authors.initials: NC
authors.lastname: Gorin
authors.affiliation: Hôpital Hautepierre, Strasbourg, France.
authors.forename: K
authors.initials: K
authors.lastname: Bilger
authors.affiliation: Hôpital Cochin, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Tamburini
authors.affiliation: Institut Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Soussain
authors.affiliation: Hôpital Avicenne, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Brechignac
authors.affiliation: Service de thérapie cellulaire et d'hématologie clinique adulte, Université d'Auvergne EA3846, CIC-501, CHU Clermont-Ferrand Hôpital Estaing, Clermont-Ferrand, France.
authors.forename: J O
authors.initials: JO
authors.lastname: Bay
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016026:Bone Marrow Transplantation; D064987:Cell- and Tissue-Based Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015994:Incidence; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012955:Societies, Medical; D015996:Survival Rate / Q000639:trends
keywords: Autologous stem cell transplantation; Elderly patients; High dose chemotherapy; Non-Hodgkin lymphoma; Treatment related mortality