title: From blood to brain through BBB and astrocytic signaling.
abstract: In this Festschrift, I discuss the career and guiding principles to which Abba J. Kastin has adhered during the last 20 years we worked together. I briefly describe the history of our joint laboratory group, the context of studies of peptide permeation across the blood-brain barrier (BBB), and newer developments in the BBB Group as Abba steps down after serving 35 years as the founding Editor-in-Chief for Peptides. Abba's BBB studies on peptides have contributed to concepts in the neuroendocrinology of feeding and developed information on molecular trafficking across BBB cells. The astroglial leptin signaling studies and the interactions of sleep and BBB are two major directions, whereas the long-term MIF-1 project demarcates a tortuous road on translational research.
authors.affiliation: Biopotentials Sleep Center, Baton Rouge, LA 70809, USA. Electronic address: sleep@biopotentials.org.
authors.forename: Weihong
authors.initials: W
authors.lastname: Pan
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000378:metabolism*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020738:Leptin / Q000266:history / Q000378:metabolism*; D009075:MSH Release-Inhibiting Hormone / Q000266:history / Q000378:metabolism*; D010506:Periodicals as Topic / Q000266:history; D015398:Signal Transduction
chemical_list: D020738:Leptin; D009075:MSH Release-Inhibiting Hormone
keywords: Circadian; Leptin; MIF-1; Obesity; Sleep; TNF