title: Urinary kidney injury molecule-1 rapid test predicts acute kidney injury in extremely low-birth-weight neonates.
abstract: BACKGROUND
  The new urinary and serum biomarkers are discovered and are being investigated. With them we can diagnose acute kidney injury (AKI) faster and more precisely and they also have a significant role in the outcome prediction.
  
  
  METHODS
  The study included 22 extremely low-birth-weight neonates who were hospitalized in the neonatal intensive care units. They were divided into two groups based on serum creatinine (SCr) level-with and without AKI. Detection and quantification of urinary kidney injury molecule-1 (uKIM-1) was done on the third day of life, using commercially available KIM-1 rapid test. Subsequently, measurements were repeated only in subjects who were diagnosed with AKI, at different values of SCr.
  
  
  RESULTS
  Logistic regression analysis showed that AKI is an independent risk factor for mortality. In a group of neonates with AKI, 50% of neonates administered the KIM-1 rapid test showed positive findings. KIM-1 rapid test was positive in patients with a wide range of SCr levels (range of 78.73-385 µmol/l), but all subjects had oliguria and died in the next 24 h.
  
  
  CONCLUSIONS
  KIM-1 is a significant predictor of death. On the other hand, our study failed to prove that KIM-1 rapid test has any significance for early prediction of AKI.
authors.affiliation: Intensive Care Unit, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.|Faculty of Medicine University of Novi Sad, Novi Sad, Serbia.
authors.forename: Vesna D
authors.initials: VD
authors.lastname: Stojanović
authors.affiliation: Intensive Care Unit, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.|Faculty of Medicine University of Novi Sad, Novi Sad, Serbia.
authors.forename: Nenad A
authors.initials: NA
authors.lastname: Barišić
authors.affiliation: Faculty of Medicine University of Novi Sad, Novi Sad, Serbia.|Centre of Pathology and Histology, Clinical Centre of Vojvodina, Vojvodina, Serbia.
authors.forename: Nada M
authors.initials: NM
authors.lastname: Vučković
authors.affiliation: Intensive Care Unit, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia.|Faculty of Medicine University of Novi Sad, Novi Sad, Serbia.
authors.forename: Aleksandra D
authors.initials: AD
authors.lastname: Doronjski
authors.affiliation: Department of Nephrology, University Children Hospital, Faculty of Medicine University of Belgrade, Belgrade, Serbia.
authors.forename: Amira E
authors.initials: AE
authors.lastname: Peco Antić
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001724:Birth Weight; D003404:Creatinine / Q000097:blood; D005260:Female; D005865:Gestational Age; D000072596:Hepatitis A Virus Cellular Receptor 1; D017052:Hospital Mortality; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D016014:Linear Models; D016015:Logistic Models; D008562:Membrane Glycoproteins / Q000652:urine*; D016017:Odds Ratio; D054238:Perinatal Mortality; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D011991:Receptors, Virus; D012307:Risk Factors; D016482:Urinalysis
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus; D003404:Creatinine