title: Sedentary time is associated with the metabolic syndrome in older adults with mobility limitations--The LIFE Study.
abstract: BACKGROUND
  Epidemiological and objective studies report an association between sedentary time and lower risk of the metabolic syndrome (MetS) and its risk factors in young and middle-age adults. To date, there is a lack of objective data on the association between sedentary time and MetS among older adults.
  
  
  METHODS
  The association between objectively measured sedentary time (accelerometry) with MetS and MetS components was examined in a large sample of older adults with mobility limitations (N=1198; mean age=78.7 ± 5.3 years) enrolled in the Lifestyle Interventions and Independence for Elders (LIFE) study. Participants were divided into tertiles according to percentage of daily sedentary time, and the relation between sedentary time with MetS and MetS components was examined after adjusting for age, sex, ethnicity, and BMI.
  
  
  RESULTS
  Participants in the highest sedentary time tertile had significantly higher odds of MetS (OR=1.54) (95% CI 1.13 to 2.11) in comparison with participants in the lowest tertile (p=0.03). Participants in the highest sedentary time tertile had larger waist circumference (p=0.0001) and lower HDL-C (p=0.0003) than participants in the lowest sedentary time tertile.
  
  
  CONCLUSIONS
  Sedentary time was strongly related to higher odds of MetS. These results, based on objectively measured sedentary time, suggest that sedentary time may represent an important risk factor for the development of MetS in older adults with high likelihood for disability.
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Rehabilitation Medicine, Erasmus University Medical Centre, Rotterdam 3000CA, The Netherlands.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Mankowski
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA; Department of Kinanthropology, University of Quebec, Montreal, Quebec H2X1Y4, Canada.
authors.forename: Mylene
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.affiliation: Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Beavers
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
authors.forename: Anda
authors.initials: A
authors.lastname: Botoseneanu
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Buford
authors.affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: Church
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Nancy W
authors.initials: NW
authors.lastname: Glynn
authors.affiliation: Stanford Prevention Research Center, Department of Medicine, Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Abby C
authors.initials: AC
authors.lastname: King
authors.affiliation: Department of Medicine Geriatrics, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Todd M
authors.initials: TM
authors.lastname: Manini
authors.affiliation: Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Marsh
authors.affiliation: Department of Internal Medicine, Northwestern Medical Faculty Foundation, Chicago, IL 60611, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: McDermott
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Joe R
authors.initials: JR
authors.lastname: Nocera
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15213, USA.
authors.forename: Elsa S
authors.initials: ES
authors.lastname: Strotmeyer
authors.affiliation: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA. Electronic address: santon@ufl.edu.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Anton
mesh_terms: D061725:Accelerometry / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology* / Q000503:physiopathology; D051346:Mobility Limitation; D009043:Motor Activity / Q000502:physiology; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:Time Factors; D055105:Waist Circumference
chemical_list: D008076:Cholesterol, HDL
keywords: Accelerometry; Aging; Disability; Glucose; Waist circumference