title: H2 S restores the cardioprotection from ischemic post-conditioning in isolated aged rat hearts.
abstract: This study explored the mechanisms underlying the recovery of myocardial protection from ischemic post-conditioning (PC) by exogenous hydrogen sulfide (H2 S) in aged rat hearts. We observed that ischemia/reperfusion (I/R) inhibited the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and promoted phosphorylation of p38 MAPK and c-Jun N-terminal kinase (JNK) in both young hearts and aged hearts. PC up-regulated ERK1/2 phosphorylations and down-regulated p38 MAPK and JNK phosphorylations. Exogenous H2 S further enhanced the role of PC in the young hearts. In the aged hearts, PC failed to affect all these 3 MAPK members, while co-treatment with exogenous H2 S-induced ERK1/2 and reduced p38 MAPK and JNK phosphorylations. These results suggest that exogenous H2 S recovers PC-induced cardioprotection via MAPK pathway in the aged hearts.
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Can
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of emergency, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Peng
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Yajun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.
authors.forename: Hongjiang
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.|The Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, 150086, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.|The Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, 150086, China.
authors.forename: Hongzhu
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Pathophysiology, Harbin Medical University, Baojian Road, Harbin, 150081, China.|The Key Laboratory of Cardiovascular Medicine Research (Harbin Medical University), Ministry of Education, Harbin, 150086, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xu
mesh_terms: D000375:Aging; D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D006321:Heart / Q000502:physiology; D006862:Hydrogen Sulfide / Q000627:therapeutic use*; D057775:Ischemic Postconditioning; D017202:Myocardial Ischemia / Q000188:drug therapy*; D009206:Myocardium / Q000201:enzymology; D009924:Organ Culture Techniques; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002316:Cardiotonic Agents; D006862:Hydrogen Sulfide
keywords: aged hearts; cardiomyocytes; hydrogen sulfide; post-conditioning