title: NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.
abstract: NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
authors.affiliation: Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
authors.forename: Carles
authors.initials: C
authors.lastname: Cantó
authors.affiliation: Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
authors.forename: Keir J
authors.initials: KJ
authors.lastname: Menzies
authors.affiliation: Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address: admin.auwerx@epfl.ch.
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D008659:Metabolic Diseases / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D009243:NAD / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000378:metabolism; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D037761:Sirtuins / Q000378:metabolism
chemical_list: D009243:NAD; D011065:Poly(ADP-ribose) Polymerases; D037761:Sirtuins