title: [The role of Wnt/β-catenin pathway and LRP5 protein in metabolism of bone tissue and osteoporosis etiology].
abstract: Osteoporosis is a metabolic bone disease, manifested by decreased bone mineral density microarchitectural disturbances of bone tissue, and increased risk of bone fractures. Owing to large-scale morbidity particularly among postmenopausal women, nowadays osteoporosis constitutes a significant global health problem. In recent years, much attention has been paid to the role of signaling Wnt/β-catenin pathway and LRP protein in the pathomechanism of osteoporosis, indicating a possible contribution of polymorphic variants of the candidate LRP5 gene to disease development. The goal of our study is to present contemporary research on signaling Wnt/β-catenin pathway and mechanism of LRP protein action in the process of bone tissue metabolism and etiology of osteoporosis.
authors.forename: Hubert
authors.initials: H
authors.lastname: Wolski
authors.forename: Natalia
authors.initials: N
authors.lastname: Drwęska-Matelska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.forename: Zdzisław
authors.initials: Z
authors.lastname: Łowicki
authors.forename: Bogusław
authors.initials: B
authors.lastname: Czerny
mesh_terms: D015519:Bone Density / Q000235:genetics; D005260:Female; D050723:Fractures, Bone / Q000378:metabolism; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics / Q000378:metabolism*; D010024:Osteoporosis / Q000235:genetics* / Q000378:metabolism*; D017698:Postmenopause / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D026502:LDL-Receptor Related Proteins; C551781:LRP4 protein, human; D051153:Wnt Proteins