title: Evaluation of Oxygen Supplementation Status as a Risk Factor Associated with the Development of Severe Retinopathy of Prematurity.
abstract: OBJECTIVE
  The effects of oxygen supplementation status and other clinical risk factors on the development of severe retinopathy of prematurity (ROP) were evaluated.
  
  
  METHODS
  Clinical records of 143 newborn infants with a gestational age of 32 weeks or less were reviewed. Severe ROP was diagnosed when photocoagulation due to progression to stage 3 was identified or when 'plus disease' developed. The factors were evaluated with univariate and multivariate logistic regression analyses between the groups with severe (n = 24) and non-severe (n = 119) ROP.
  
  
  RESULTS
  Gestational age, birth weight, duration of oxygen supplementation, duration of directional positive air pressure and maximum fraction of inspiratory oxygen (FiO2) were significantly associated with severe ROP in the univariate analyses. In the multivariate analysis, a longer duration of oxygen supplementation and a higher maximum FiO2 were revealed as significant risk factors associated with severe ROP.
  
  
  CONCLUSIONS
  Duration of oxygen supplementation and maximum FiO2 required were important factors associated with severe ROP.
authors.affiliation: Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Enomoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Miki
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsumiya
authors.forename: Shigeru
authors.initials: S
authors.lastname: Honda
mesh_terms: D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D017075:Laser Coagulation; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D011175:Positive-Pressure Respiration; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012178:Retinopathy of Prematurity / Q000145:classification / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors