title: Toward Naphthocyclinones: Doubly Connected Octaketide Dimers with a Bicyclo[3.2.1]octadienone Core by Thiolate-Mediated Cyclization.
abstract: A viable method is reported for the synthesis of the bicyclo[3.2.1]octadienone scaffold in naturally occurring octaketide dimers. The procedure employs a reductive cyclization reaction mediated by an unusual ethanedithiol monosodium salt.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8551 (Japan).
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ando
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8551 (Japan).
authors.forename: Subaru
authors.initials: S
authors.lastname: Hori
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8551 (Japan).
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukazawa
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8551 (Japan). kohmori@chem.titech.ac.jp.
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmori
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro, Tokyo 152-8551 (Japan). ksuzuki@chem.titech.ac.jp.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
keywords: cyclization; dimerization; dithiol reagents; quinones; synthetic methods