title: The Association between Obstructive Sleep Apnea and Metabolic Markers and Lipid Profiles.
abstract: OBJECTIVE
  The purpose of this study was to investigate the association between apnea-hypopnea index (AHI) and metabolic markers and whether the elevated risk of Metabolic Syndrome (MetS) is related to Obstructive Sleep Apnea (OSA).
  
  
  METHODS
  This cross-sectional study recruited 246 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test and by blood lipids examination. Severity of OSA was categorized according to the apnea-hypopnea index (AHI).
  
  
  RESULTS
  The results showed that a 73.3% prevalence of MetS in OSA (AHI > 15) and a 80.0% prevalence of MetS in severe OSA (AHI > 30) were found. After adjusting for confounding variables, an increased level of Body-Mass Index (BMI) and two non-MetS cardiovascular risk factors, total cholesterol/HDL-C ratio and TG/HDL-C ratio was significantly associated with AHI in subjects with severe OSA. MetS was about three times to be present in subjects with severe OSA, even adjusted for BMI.
  
  
  CONCLUSIONS
  The findings showed a high prevalence of MetS in OSA among professional drivers, especially in the severe group category. BMI was the major contributing factor to OSA. However, the present study did not find a sensitive clinical marker of a detrimental metabolic profile in OSA patients.
authors.affiliation: National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
authors.forename: Wei-Te
authors.initials: WT
authors.lastname: Wu
authors.affiliation: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Su-Shan
authors.initials: SS
authors.lastname: Tsai
authors.affiliation: Institute of Labor, Occupational Safety And Health, Ministry of Labor, Taipei, Taiwan.
authors.forename: Tung-Sheng
authors.initials: TS
authors.lastname: Shih
authors.affiliation: Institute of Labor, Occupational Safety And Health, Ministry of Labor, Taipei, Taiwan.
authors.forename: Ming-Hsiu
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Department of Public Health, China Medical University, Taichung, Taiwan.
authors.forename: Tzu-Chieh
authors.initials: TC
authors.lastname: Chou
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chung-Shan Medical University, Taichung, Taiwan; Center of Sleep Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan.
authors.forename: Hua
authors.initials: H
authors.lastname: Ting
authors.affiliation: National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Nursing, HungKuang University, Taichung, Taiwan.
authors.forename: Trong-Neng
authors.initials: TN
authors.lastname: Wu
authors.affiliation: National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan; Department of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Saou-Hsing
authors.initials: SH
authors.lastname: Liou
mesh_terms: D000328:Adult; D015415:Biomarkers; D001786:Blood Glucose; D001794:Blood Pressure; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010101:Oxygen Consumption; D017286:Polysomnography; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids