title: [Clinical study on FibroTouch and multi-parameter model for diagnosis of hepatic fibrosis in patients with chronic liver disease].
abstract: OBJECTIVE
  To explore the clinical application and related factors of FibroTouch in the diagnosis of liver fibrosis in patients with chronic liver disease through comparison of the specificity and sensitivity of FibroTouch and multi-parameter models, and to identify whether FibroTouch is a more accurate and safe method in diagnosis of liver fibrosis and evaluation of the therapeutic effect.
  
  
  METHODS
  A total of 190 patients with chronic liver disease were performed liver biopsy and underwent liver stiffness measurement (LSM) using FibroTouch in department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University from January 2014 to February 2015. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) were tested by enzymic method with automatic biochemistry analyzer. Blood platelet counts were detected by automatic blood cell analyzer. AST-to-PLT ratio index (APRI) and fibrosis index based on the 4 factor (FIB-4) were calculated. The diagnostic values of FibroTouch, APRI and FIB-4 for liver fibrosis degree were calculated and compared by receiver operating characteristic (ROC) curves. The related factors of LSM were analyzed by Spearman analysis.
  
  
  RESULTS
  There was significant correlation between LSM and histological fibrosis (r=0.804, P=0.000). The area under ROC curve of LSM for S(≥2, S≥3 and S=4 was 0.894, 0.938 and 0.961, respectively, which was significantly higher than APRI (0.678, 0.698 and 0.658) and FIB-4 (0.765, 0.785 and 0.775). On Spearman analysis, LSM was positively correlated with age, ALT, AST, TBIL ((≥2×ULN) and the grade of liver inflammation (r=0.309, 0.558, 0.504, 0.492 and 0.532, respectively) but negatively with PLT (r=-0.444), (all P<0.05).
  
  
  CONCLUSIONS
  LSM is a convenient and reliable approach for diagnosis of liver fibrosis in patients with chronic liver disease. The sensitivity and specificity of Fibrotouch in diagnosis of hepatic fibrosis is superior to APRI and FIB-4, and age, high level ofALT, AST and TBIL (≥2×ULN) were independent predictors of LSM inaccuracy.
authors.affiliation: Department of Traditional and western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Rongqi
authors.initials: R
authors.lastname: Wang
authors.forename: Weiguang
authors.initials: W
authors.lastname: Ren
authors.forename: Suxian
authors.initials: S
authors.lastname: Zhao
authors.forename: Xuemin
authors.initials: X
authors.lastname: Niu
authors.forename: Pufang
authors.initials: P
authors.lastname: Tan
authors.forename: Huijuan
authors.initials: H
authors.lastname: Du
authors.forename: Yuemin
authors.initials: Y
authors.lastname: Nan
mesh_terms: D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D001663:Bilirubin; D015415:Biomarkers; D001706:Biopsy; D002908:Chronic Disease; D006801:Humans; D008103:Liver Cirrhosis; D010976:Platelet Count; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin