title: [IMMUNE AND ATOPIC STATUS OF SCHOOL-AGE CHILDREN WITH ASTHMA, GIVEN THE ASTHMA PHENOTYPE].
abstract: 25 students of the phenotypes of early-onset and late-onset asthma were investigated. In statistically significant majority of patients with early-onset asthma was detected skin hypersensitivity to household and epidermal allergens and clear trend to higher concentrations of IL-4 in the serum, which indirectly indicates on atopic reactivity. Almost every second child with late-onset asthma, had a high level of IL-8 (more than 7.62 pg/ml), while the odds ratio detection of increased serum concentrations of IL-8 was 3.1 (95% CI 1.6-6) that was assotiate with neutrophil-mediated immune response. There were defined clinical and epidemiological risk and diagnostic value of atopic reactivity indices for the verification study asthma phenotypes.
authors.forename: U I
authors.initials: UI
authors.lastname: Marusyk
mesh_terms: D001249:Asthma / Q000097:blood / Q000209:etiology / Q000276:immunology*; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D010641:Phenotype; D011237:Predictive Value of Tests
chemical_list: C508598:IL4 protein, human; D016209:Interleukin-8; D015847:Interleukin-4