title: The molecular ticks of the Drosophila circadian clock.
abstract: Drosophilais a powerful model to understand the mechanisms underlying circadian rhythms. TheDrosophilamolecular clock is comprised of transcriptional feedback loops. The expressions of the critical transcriptional activator CLK and its repressors PER and TIM are under tight transcriptional control. However, posttranslational modification of these proteins and regulation of their stability are critical to their function and to the generation of 24-hr period rhythms. We review here recent progress made in our understanding of PER, TIM and CLK posttranslational control. We also review recent studies that are uncovering the importance of novel regulatory mechanisms that affect mRNA stability and translation of circadian pacemaker proteins and their output.
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Tataroglu
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605.
authors.forename: Patrick
authors.initials: P
authors.lastname: Emery