title: Fibromyalgia incidence among patients with hepatitis B infection.
abstract: OBJECTIVE
  The purpose of our investigation was to evaluate the incidence of fibromyalgia syndrome (FMS) and identify FMS-related clinical symptoms in hepatitis B virus (HBV) patients.
  
  
  METHODS
  One hundred and eighteen HBV surface antigen (HbsAg)-positive patients (40 with chronic active hepatitis B, 40 hepatitis B carriers and 38, all of whom had been antiretroviral-treated for at least 3 months) were included in this study. In addition, 60 age- and gender-matched HbsAg-negative healthy controls were included in the study.
  
  
  RESULTS
  There was no significant difference in age, gender or body mass index (BMI) between the two groups (P > 0.05). Serum aspartate aminotransferase and alanine aminotransferase levels were significantly higher in HBV patients relative to the control group (P < 0.05). The incidence of FMS, widespread body pain, fatigue, sleep disturbance, anxiety, morning stiffness, arthralgia was significantly greater among HBV patients relative to the control group. Additionally, the mean tender point counts and the visual analog scale values were significantly higher among the HBV patients (P < 0.05).
  
  
  CONCLUSIONS
  The results of the present study demonstrate that FMS incidence is greater among HBV patients relative to control subjects. However, there were no differences in FMS incidence among the subgroups of HBV diagnoses.
authors.affiliation: Departments of Physical Medicine and Rehabilitation, Dicle University, Diyarbakır, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Yazmalar
authors.affiliation: Departments of Infectious Disease and Clinical Microbiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Özcan
authors.initials: Ö
authors.lastname: Deveci
authors.affiliation: Departments of Physical Medicine and Rehabilitation, Dicle University, Diyarbakır, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Batmaz
authors.affiliation: Departments of Infectious Disease and Clinical Microbiology, Dicle University, Diyarbakır, Turkey.
authors.forename: Davut
authors.initials: D
authors.lastname: İpek
authors.affiliation: Departments of Family Physician, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Tahsin
authors.initials: T
authors.lastname: Çelepkolu
authors.affiliation: Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yüzüncüyıl University, Van, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Alpaycı
authors.affiliation: Departments of Physical Medicine and Rehabilitation, Dicle University, Diyarbakır, Turkey.
authors.forename: Erkam
authors.initials: E
authors.lastname: Hattapoğlu
authors.affiliation: Departments of Physical Medicine and Rehabilitation, Dicle University, Diyarbakır, Turkey.
authors.forename: Dicle
authors.initials: D
authors.lastname: Akdeniz
authors.affiliation: Departments of Physical Medicine and Rehabilitation, Dicle University, Diyarbakır, Turkey.
authors.forename: Mustafa A
authors.initials: MA
authors.lastname: Sarıyıldız
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D014421:Turkey / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens
keywords: fibromyalgia syndrome; hepatitis B; pain