title: [α-GalCer reduces Acute Graft-versus-Host Disease by Altering Donor T Cells Migration].
abstract: OBJECTIVE
  This study was aimed to explore the new mechanism of α-Galactosyleramide (α-GalCer), a synthetic glycolipid, and a well-known activator of natural killer T cells (NKT) for improving acute graft-versus-host disease(aGVHD).
  
  
  METHODS
  Murine allogeneic bone marrow transplantation (allo-BMT) model was established. Recipient mice were injected intraperitoneally with α-GalCer immediately after allo-BMT, whereas mice from the vehicle groups received the diluent (DMSO) only. The severity degree of aGVHD was estimated by survival, aGVHD clinical score and pathology. The mechanism of aGVHD reduced by α-GalCer was explored by detecting T cells migration in vivo and in vitro.
  
  
  RESULTS
  Mice in α-GalCer group survived longer than in control group, and their clinical and pathological status of aGVHD were lighter. α-GalCer reduced aGVHD by altering donors T cell migration.
  
  
  CONCLUSIONS
  After allo-BMT α-GalCer reduces aGVHD by altering donor T cells migration.
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China. E-mail: zhoufan611@sina.com.cn.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Min-Yan
authors.initials: MY
authors.lastname: Li
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Yan-Qin
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Ji-Gang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: Department of Hematology, General Hospital of Shenyang Military Command, Shenyang 110016, Liaoning Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000208:Acute Disease; D000818:Animals; D016026:Bone Marrow Transplantation; D002465:Cell Movement; D006086:Graft vs Host Disease; D051379:Mice; D055611:Natural Killer T-Cells; D014019:Tissue Donors; D014184:Transplantation, Homologous