title: Genetics of anaplastic large cell lymphoma.
abstract: Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin lymphomas unified by common morphologic and immunophenotypic characteristics, but with a spectrum of clinical presentations and behaviors. Early identification of anaplastic lymphoma kinase (ALK) gene rearrangements in some ALCLs led to recognition of ALK as an important diagnostic and prognostic biomarker, and a key driver of ALCL pathobiology. Rearrangements and other genetic abnormalities of ALK subsequently were identified in diverse other human malignancies. Recent clinical, pathologic, and genetic data have begun to shed light on ALK-negative ALCLs, revealing significant heterogeneity within this more ill-defined entity.
authors.affiliation: a Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.|b Department of Pathology , Tongji Hospital, Tongji University School of Medicine , Shanghai , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: a Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester , MN , USA.
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Feldman
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002869:Chromosome Aberrations; D056915:DNA Copy Number Variations; D020869:Gene Expression Profiling; D015321:Gene Rearrangement; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Anaplastic large cell lymphoma; DUSP22; T-cell non-Hodgkin lymphoma; anaplastic lymphoma kinase (ALK); genetics; p63