title: Group 2 innate lymphoid cells and asthma.
abstract: Group 2 innate lymphoid cells (ILC2s) are recently identified cell populations that produce type 2 cytokines such as IL-5 and IL-13 in response to epithelial cell-derived cytokines. Although ILC2s were initially reported to play a key role in the anti-helminth innate immunity, we now have greater interest in their role in asthma and other allergic diseases. In various asthma mouse models, ILC2s provoke eosinophilic inflammation accompanied by airway hyperresponsiveness independent of acquired immunity. Moreover, recent mouse studies show that ILC2s also promote acquired immunity and Th2 polarization, and various cytokines and lipid mediators influence the functions of ILC2s. Although ILC2s have also been identified in humans, studies on the role of human ILC2s in asthma are very limited. Thus far, human studies have shown that there is a slight difference in responsiveness and production of cytokines between mouse and human ILC2s, and it has been suggested that ILC2s are involved in allergic-type asthma and the exacerbation of asthma. In this review, we focus on mouse and human ILC2s, and discuss their role in asthma.
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Internal Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan; Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kabata
authors.affiliation: Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Tokyo, Japan; Division of Immunobiology, Department of Medical Life Science, Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan.
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Moro
authors.affiliation: Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Japan; Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Koyasu
authors.affiliation: Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: ko-asano@tokai-u.jp.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Asano
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines
keywords: Allergy; IL-25; IL-33; Innate immunity; Type 2 cytokines