title: Genome-wide association with residual body weight gain in Bos indicus cattle.
abstract: Weight gain is a key performance trait for beef cat-tle; however, attention should be given to the production costs for better profitability. Therefore, a feed efficiency trait based on per-formance can be an interesting approach to improve performance without increasing food costs. To identify candidate genes and ge-nomic regions associated with residual body weight gain (RWG), we conducted a genome-wide association study (GWAS) with 720 Nellore cattle using the GRAMMAR-Gamma association test. We identified 30 significant single nucleotide polymorphisms (SNPs), especially on chromosomes 2, 8, 12, and 17. Several genes and quantitative train loci (QTLs) present in the regions identified were appointed; we highlight DMRT2 (doublesex and mab-3 related tran-scription factor 2), IFFO2 (intermediate filament family orphan 2), LNX2 (ligand of numb-protein X 2), MTIF3 (mitochondrial transla-tional initiation factor 3), and TRNAG-CCC (transfer RNA glycine anticodon CCC). The metabolic pathways that can explain part of the phenotypic variation in RWG are related to oxidative stress and muscle control.
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil miguel-has@hotmail.com.
authors.forename: M H A
authors.initials: MH
authors.lastname: Santana
authors.affiliation: Empresa Brasileira de Pesquisa Agropecuária, Campo Grande, MS, Brasil.
authors.forename: R C
authors.initials: RC
authors.lastname: Gomes
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: Y T
authors.initials: YT
authors.lastname: Utsunomiya
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: H H R
authors.initials: HH
authors.lastname: Neves
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil.
authors.forename: F J
authors.initials: FJ
authors.lastname: Novais
authors.affiliation: Empresa Brasileira de Pesquisa Agropecuária, Campo Grande, MS, Brasil.
authors.forename: M N
authors.initials: MN
authors.lastname: Bonin
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil.
authors.forename: H
authors.initials: H
authors.lastname: Fukumasu
authors.affiliation: Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, Brasil.
authors.forename: J F
authors.initials: JF
authors.lastname: Garcia
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil.
authors.forename: P A
authors.initials: PA
authors.lastname: Alexandre
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil.
authors.forename: G A
authors.initials: GA
authors.lastname: Oliveira Junior
authors.affiliation: Escola Superior de Agricultura Luiz de Queiroz, Universidade de São Paulo, Piracicaba, SP, Brasil.
authors.forename: L L
authors.initials: LL
authors.lastname: Coutinho
authors.affiliation: Faculdade de Zootecnia e Engenharia de Alimentos, Pirassununga, SP, Brasil.
authors.forename: J B S
authors.initials: JB
authors.lastname: Ferraz
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics*; D002417:Cattle; D055106:Genome-Wide Association Study; D005838:Genotype; D053858:Metabolic Networks and Pathways / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci / Q000235:genetics*; D015430:Weight Gain / Q000235:genetics*