title: Brain network connectivity-behavioral relationships exhibit trait-like properties: Evidence from hippocampal connectivity and memory.
abstract: Despite a growing number of studies showing relationships between behavior and resting-state functional MRI measures of large-scale brain network connectivity, no study to our knowledge has sought to investigate whether intrinsic connectivity-behavioral relationships are stable over time. In this study, we investigated the stability of such brain-behavior relationships at two timepoints, approximately 1 week apart. We focused on the relationship between the strength of hippocampal connectivity to posterior cingulate cortex and episodic memory performance. Our results showed that this relationship is stable across samples of a different age and reliable over two points in time. These findings provide the first evidence that the relationship between large-scale intrinsic network connectivity and episodic memory performance is a stable characteristic that varies between individuals.
authors.affiliation: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Touroutoglou
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Andreano
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Department of Psychology, Northeastern University, Boston, Massachusetts.
authors.forename: Lisa Feldman
authors.initials: LF
authors.lastname: Barrett
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Psychiatric Neuroimaging Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.|Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 149 13th St., Charlestown, Massachusetts.
authors.forename: Bradford C
authors.initials: BC
authors.lastname: Dickerson
mesh_terms: D000293:Adolescent; D000328:Adult; D001245:Association Learning / Q000502:physiology*; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D012146:Rest; D013995:Time; D055815:Young Adult
keywords: hippocampus; individual differences; memory; reliability; resting-state fMRI