title: Saturated, Monounsaturated and Polyunsaturated Fatty Acids Intake and Risk of Pancreatic Cancer: Evidence from Observational Studies.
abstract: BACKGROUND
  Although the relationship between dietary monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and saturated fatty acids (SFAs) intake and pancreatic cancer risk has been reported by several studies, the evidence is controversial. We firstly conducted this comprehensive meta-analysis to summarize the aforementioned evidence from observational studies.
  
  
  METHODS
  The MEDLINE (PubMed), Embase, and ISI Web of Science databases were used to search for epidemiological studies of dietary SFA, MUFA, and PUFA and pancreatic cancer risk that were published until the end of June 2014. Random- or fixed-effects models were used to estimate the relative risks (RRs) and 95% confidence intervals (CIs). We also carried out subgroup, sensitivity, and publication bias analyses.
  
  
  RESULTS
  We identified 13 case-control studies and 7 prospective studies which including 6270 pancreatic cancer cases in the meta-analysis of SFA, MUFA, and PUFA and risk of pancreatic cancer. The summary RR was 1.13 (95%CI = 0.94-1.35, I2 = 70.7%) for SFA, 1.00 (95%CI = 0.87-1.14, I2 = 43.4%) for MUFA, and 0.87 (95%CI = 0.75-1.00, I2 = 55.3%) for PUFA for high versus low intake categories. We found no evidence of publication bias.
  
  
  CONCLUSIONS
  In summary, findings of this study supports an inverse association between diets high in PUFA and pancreatic cancer risk. Further large prospective studies are warranted to report the results stratified by the subtypes of MUFA and PUFA and adjust for other potential risk factors to eliminate residual confounding.
authors.affiliation: Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yao
authors.affiliation: Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang, P. R. China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Tian
mesh_terms: D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects; D005231:Fatty Acids, Unsaturated / Q000009:adverse effects; D006801:Humans; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D012306:Risk
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated