title: DNA display of glycoconjugates to emulate oligomeric interactions of glycans.
abstract: Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate units, assemblies based on hybridization of nucleic acid conjugates have been used to display simplified ligands with tailored interligand distances and valences. The programmability of the assemblies lends itself to a combinatorial display of multiple ligands. Recent efforts in the synthesis and applications of such conjugates are discussed.
authors.affiliation: Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30, quai Ernest Ansermet, 1211 Geneva, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Novoa
authors.affiliation: Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30, quai Ernest Ansermet, 1211 Geneva, Switzerland.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Winssinger
keywords: DNA display; glycan; glycoconjugate; multivalency; nucleic acid conjugates; oligomeric interaction