title: Association of interleukin-12 gene polymorphisms with cancer susceptibility: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association between interleukin-12 (IL-12) gene polymorphism and cervical cancer susceptibility.
  
  
  METHODS
  We comprehensively retrieved the relevant English and Chinese database to collect case-control studies on the association between the IL-12 gene polymorphism and cervical cancer susceptibility. Data were extracted independently by two researchers respectively, the summary data were analyzed using Revman 5.2 software, the association was described using odds ratios (OR) and 95% confidence intervals (95% CI).
  
  
  RESULTS
  According to inclusion and exclusion criteria, 5 case-control studies involving 2552 cervical cancer patients and 2232 healthy controls were included. The meta-analysis results showed that 3'UTR+1188 (rs3212227) polymorphism in IL-12 gene was not associated with cervical cancer risk (C vs. A: OR=1.09, 95% CI: 0.88~1.35, P=0.45; AA+AC vs. CC: OR=0.88, 95% CI: 0.67~1.15, P=0.34; AA vs. AC+CC: OR=0.89. 95% CI: 0.56-1.42, P=0.62; CC vs. AA: OR=1.30. 95% CI: 0.79-2.12, P=0.30).
  
  
  CONCLUSIONS
  The available evidence suggested that rs3212227 polymorphism in IL-12 gene may not be the risk factor to cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Yuhuangding Hospital Affiliated to Qingdao University Yantai 264000, P. R. China.
authors.forename: Su-Wen
authors.initials: SW
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Qixia People's Hospital Qixia 265300, P. R. China.
authors.forename: Gui-Qin
authors.initials: GQ
authors.lastname: Xu
authors.affiliation: Department of Obstetrics and Gynecology, Yuhuangding Hospital Affiliated to Qingdao University Yantai 264000, P. R. China.
authors.forename: Yong-Ling
authors.initials: YL
authors.lastname: Fan
keywords: Interleukin 12; cervical cancer; meta-analysis; single nucleotide polymorphism