title: Oncocalyxone A functions as an anti-glycation agent in vitro.
abstract: Advanced glycation endproducts (AGE) are the result of post-translational changes to proteins, which ultimately compromise their structure and/or function. The identification of methods to prevent the formation of these compounds holds great promise in the development of alternative therapies for diseases such as diabetes. Plants used in traditional medicine are often rich sources of anti-glycation agents. Therefore, in this study, we investigated the anti-glycation activity of one such compound, Oncocalyxone A (Onco A). Using spectrofluorimetric techniques, we determined that Onco A inhibits AGE formation in a concentration-dependent manner. Its IC50 value (87.88 ± 3.08 μM) was almost two times lower than the standard anti-glycation compound aminoguanidine (184.68 ± 4.85 μM). The excellent anti-glycation activity of Onco A makes it an exciting candidate for the treatment of diseases associated with excessive accumulation of AGE. However, additional studies are necessary to identify its mechanism of action, as well as the in vivo response in suitable model organisms.
authors.affiliation: Instituto de Química e Biotecnologia, Universidade Federal de Alagoas. Endereço: Cidade universitária, BR 101 (km 14), Tabuleiro dos Martins, CEP, 57072-970, Maceió, AL, Brasil; Departamento de agroindústria, Instituto Federal de Alagoas. Endereço: Conjunto Residencial Astolfo Lopes, s/n-Cidade Alta, CEP, 57820-000, Murici, AL, Brasil.
authors.forename: Ingrid Sofia Vieira de
authors.initials: IS
authors.lastname: Melo
authors.affiliation: Departamento de Química, Universidade Estadual de Alagoas. Endereço: Av. Governador Luís Cavalcante, Alto do Cruzeiro, CEP, 57312-270, Arapiraca, AL, Brasil.
authors.forename: Aldenir Feitosa Dos
authors.initials: AF
authors.lastname: Santos
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará. Endereço: Av. Mister Hull, Campus do Pici, CEP, 60451-970, Fortaleza, CE, Brasil.
authors.forename: Telma Leda Gomes de
authors.initials: TL
authors.lastname: Lemos
authors.affiliation: Instituto de Química e Biotecnologia, Universidade Federal de Alagoas. Endereço: Cidade universitária, BR 101 (km 14), Tabuleiro dos Martins, CEP, 57072-970, Maceió, AL, Brasil.
authors.forename: Marília Oliveira Fonseca
authors.initials: MO
authors.lastname: Goulart
authors.affiliation: Instituto de Química e Biotecnologia, Universidade Federal de Alagoas. Endereço: Cidade universitária, BR 101 (km 14), Tabuleiro dos Martins, CEP, 57072-970, Maceió, AL, Brasil.
authors.forename: Antônio Euzébio Goulart
authors.initials: AE
authors.lastname: Santana
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology; D001938:Brazil; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005632:Fructose / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D006031:Glycosylation; D020128:Inhibitory Concentration 50; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D000880:Anthraquinones; D017127:Glycation End Products, Advanced; D010936:Plant Extracts; C408504:oncocalyxone A; D012710:Serum Albumin, Bovine; D005632:Fructose; D005947:Glucose