title: PP002. Metabolomic biomarkers in serum and urine of preeclamptic women.
abstract: BACKGROUND
  Preeclampsia (PE) affects about 3% of pregnancies. The syndrome cannot be accurately predicted, and large variation complicates the search for early biomarkers. Metabolites are components of the metabolism; the chemical interactions in the body necessary for life. Metabolomics, the study of metabolism, has been used to characterize diabetes, cancer and cardiovascular disease (CVD).
  
  
  OBJECTIVE
  Explore the use of magnetic resonance (MR) metabolomics on PE, and to elucidate potential clues to PE etiology and pathogenesis.
  
  
  METHODS
  Serum and urine from non-pregnant women (n=10) and pregnant women with PE (n=10) or normal pregnancies (n=10), was analyzed with MR spectroscopy and subjected to multivariate analysis (MVA). Metabolites were quantified and compared between groups.
  
  
  RESULTS
  Urine and serum samples revealed differences between PE and both control groups. Ten urine metabolites were significantly different between the three groups. Urine samples from women with early-onset PE clustered together in MVA. PE serum spectra had higher levels of low and very-low density lipoproteins, and lower high-density lipoproteins compared to control groups.
  
  
  CONCLUSIONS
  PE and control samples were effectively discriminated using MR metabolomics, suggesting that MR metabolomics is a useful method for improved sub-phenotyping of PE in larger studies. Information relevant to the disease was found both for serum and urine samples, and indicated similarities between PE and CVD.
authors.forename: Marie
authors.initials: M
authors.lastname: Austdal
authors.forename: Ragnhild Bergene
authors.initials: RB
authors.lastname: Skråstad
authors.forename: Astrid Solberg
authors.initials: AS
authors.lastname: Gundersen
authors.forename: Rigmor
authors.initials: R
authors.lastname: Austgulen
authors.forename: Tone Frost
authors.initials: TF
authors.lastname: Bathen
authors.forename: Ann-Charlotte
authors.initials: AC
authors.lastname: Iversen