title: ASSOCIATION OF TEMPORAL LOBE INFLAMMATORY LEUKOENCEPHALOPATHY WITH TWO B CELL MALIGNANCIES.
abstract: Identification of etiological connections among virtually distinct diseases in a patient may be sometimes challenging. We report a unique case with two B cell malignancies and an inflammatory leukoencephalopathy. Three days prior to admission, the elderly male patient developed fatigue, headaches, recurrent vomiting, memory disturbances, depression and somnolence. Clinical, laboratory and imaging evaluations as well as post mortem histological studies were performed. Simultaneous presence of primary central nervous system B cell lymphoma, temporal lobe inflammatory leukoencephalopathy and multiple (smoldering) myeloma, was revealed by the detailed work up in the treatment-naïve patient. Based on recent data from genomic studies, we propose that a sequential evolution of molecular pathology lead to the co-occurrence of multiple myeloma and primary central nervous system B cell lymphoma in this patient, and interpret the development of the temporal lobe leukoencephalopathy as a likely paraneoplastic complication of smoldering myeloma.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Garzuly
authors.forename: Katalin
authors.initials: K
authors.lastname: Hahn
authors.forename: László János
authors.initials: LJ
authors.lastname: Iványi
authors.forename: László
authors.initials: L
authors.lastname: Kereskai
authors.forename: Valéria
authors.initials: V
authors.lastname: Gábor
authors.forename: Gábor G
authors.initials: GG
authors.lastname: Kovács
authors.forename: Herbert
authors.initials: H
authors.lastname: Budka
authors.forename: Bernadette
authors.initials: B
authors.lastname: Kalman
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D007249:Inflammation; D056784:Leukoencephalopathies / Q000150:complications / Q000175:diagnosis; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis; D010257:Paraneoplastic Syndromes; D018805:Sepsis / Q000209:etiology; D013702:Temporal Lobe / Q000737:chemistry / Q000473:pathology
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D016827:CD8 Antigens; D007166:Immunosuppressive Agents