title: Changes of resting cerebral activities in subacute ischemic stroke patients.
abstract: This study aimed to detect the difference in resting cerebral activities between ischemic stroke patients and healthy participants, define the abnormal site, and provide new evidence for pathological mechanisms, clinical diagnosis, prognosis prediction and efficacy evaluation of ischemic stroke. At present, the majority of functional magnetic resonance imaging studies focus on the motor dysfunction and the acute stage of ischemic stroke. This study recruited 15 right-handed ischemic stroke patients at subacute stage (15 days to 11.5 weeks) and 15 age-matched healthy participants. A resting-state functional magnetic resonance imaging scan was performed on each subject to detect cerebral activity. Regional homogeneity analysis was used to investigate the difference in cerebral activities between ischemic stroke patients and healthy participants. The results showed that the ischemic stroke patients had lower regional homogeneity in anterior cingulate and left cerebrum and higher regional homogeneity in cerebellum, left precuneus and left frontal lobe, compared with healthy participants. The experimental findings demonstrate that the areas in which regional homogeneity was different between ischemic stroke patients and healthy participants are in the cerebellum, left precuneus, left triangle inferior frontal gyrus, left inferior temporal gyrus and anterior cingulate. These locations, related to the motor, sensory and emotion areas, are likely potential targets for the neural regeneration of subacute ischemic stroke patients.
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, China.
authors.forename: Yong-Xin
authors.initials: YX
authors.lastname: Li
authors.affiliation: The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Bai-Li
authors.initials: BL
authors.lastname: Yu
authors.affiliation: Radiology Department, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Qiu
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Zhou
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
authors.forename: Fan-Rong
authors.initials: FR
authors.lastname: Liang
keywords: NSFC grants; apoplexy; brain activity; brain injury; functional magnetic resonance imaging; healthy; ischemia; nerve regeneration; neural regeneration; neuroimaging; participants; regional homogeneity; subacute; volunteers