title: Changes in LDL Oxidative Status and Oxidative and Inflammatory Gene Expression after Red Wine Intake in Healthy People: A Randomized Trial.
abstract: Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing low density lipoproteins (LDL) oxidation via induction of antioxidant enzymes. We evaluated the gene expression of oxidative stress (HOSp), inflammasome (HIp), and human drug metabolism pathways (HDM) and ox-LDL level at baseline and after the intake of red wine naturally enriched with resveratrol (NPVRW), in association with or without a McDonald's meal (McDM). The ox-LDL levels significantly increase comparing baseline (B) versus McDM and decreased comparing McDM versus McDM + NPVRW (P ≤ 0.05). Percentages of significant genes expressed after each nutritional intervention were the following: (1) B versus McDM, 2.88% HOSp, 2.40% of HIp, and 3.37% of HDMp; (2) B versus McDM + NPVRW, 1.44% of HOSp, 4.81% of HIp, and 0.96% of HDMp; (3) McDM versus McDM + NPVRW, 2.40% of HOSp, 2.40% of HIp, and 5.77% of HDMp; (4) B versus NPVRW, 4.80% HOSp, 3.85% HIp, and 3.85% HDMp. NPVRW intake reduced postprandial ox-LDL and the expression of inflammation and oxidative stress related genes. Chronic studies on larger population are necessary before definitive conclusions.
authors.affiliation: Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Di Renzo
authors.affiliation: Division of Legal Medicine and Social Security, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Luigi Tonino
authors.initials: LT
authors.lastname: Marsella
authors.affiliation: Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Alberto
authors.identifier: 0000-0003-4274-4035
authors.initials: A
authors.lastname: Carraro
authors.affiliation: Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Roberto
authors.identifier: 0000-0001-8702-5670
authors.initials: R
authors.lastname: Valente
authors.affiliation: Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Gualtieri
authors.affiliation: Department of Surgery and Medical Science, University "Magna Græcia", 88100 Germaneto, Italy.
authors.forename: Santo
authors.initials: S
authors.lastname: Gratteri
authors.affiliation: Council for Agricultural Research and Experimentation-Viticulture Centre (CRA-VIT), 31015 Conegliano, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Tomasi
authors.affiliation: Council for Agricultural Research and Experimentation-Viticulture Centre (CRA-VIT), 31015 Conegliano, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Gaiotti
authors.affiliation: Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy ; National Institute for Mediterranean Diet and Nutrigenomics (I.N.DI.M.), 87032 Amantea, Italy.
authors.forename: Antonino
authors.identifier: 0000-0001-6524-4493
authors.initials: A
authors.lastname: De Lorenzo
mesh_terms: D000328:Adult; D004032:Diet; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D008077:Lipoproteins, LDL / Q000032:analysis*; D008875:Middle Aged; D018384:Oxidative Stress; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014920:Wine
chemical_list: D008077:Lipoproteins, LDL; D004364:Pharmaceutical Preparations; C099252:oxidized low density lipoprotein