title: [Regulation of uterine blood flow. I. Functions of estrogen and estrogen receptor α/β in the uterine vascular endothelium during pregnancy].
abstract: Estrogen and classical estrogen receptors (ERs), ER-α and ER-β, have been shown to be partially responsible for short and long term uterine endothelial adaptations during pregnancy. The molecular and structural differences, together with the various effects caused by these receptors in cells and tissues, suggest that their function varies depending upon estrogen and estrogen receptor signaling. In this review, we discuss the role of estrogen and its classic receptors in the cardiovascular adaptations during pregnancy and the expression of ERs in vivo and in vitro in the uterine artery endothelium during the ovarian cycle and pregnancy, while comparing their expression in arterial endothelium from reproductive and non-reproductive tissues. These themes integrate current knowledge of this broad scientific field with various interpretations and hypothesis that related estrogenic effects by either one or both ERs. This review also includes the relationship with vasodilator and angiogenic adaptations required to modulate the dramatic physiological increase to the uteroplacental perfusion observed during normal pregnancy.
authors.affiliation: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecoloaía y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA.
authors.forename: Pastore R
authors.initials: PR
authors.lastname: Mayra
authors.affiliation: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecoloaía y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA.
authors.forename: Villalón L
authors.initials: VL
authors.lastname: Rosalina
authors.affiliation: Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecoloaía y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA.
authors.forename: Gladys
authors.initials: G
authors.lastname: López
authors.affiliation: Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento de Obstetricia y Ginecología de la División de Medicina Materno-Fetal. Universidad de Wisconsin-Madison, Wisconsin, USA.
authors.forename: Jesús
authors.initials: J
authors.lastname: Iruretagoyena
authors.affiliation: Programa de Endocrinología y Fisiología Reproductiva, Universidad de Wisconsin-Madison, Wisconsin, USA ; Laboratorio de Investigación Perinatal, Departamento de Obstetricia y Ginecoloaía y División de Ciencias de la Reproducción, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento Perinatal, Universidad de Wisconsin-Madison, Wisconsin, USA ; Departamento de Ciencias de Animales, Universidad de Wisconsin-Madison, Wisconsin, USA.
authors.forename: Ronald
authors.initials: R
authors.lastname: Magness