title: Blood pressure in pregnancy and magnesium sensitive genes.
abstract: OBJECTIVE
  High blood pressure during the last part of pregnancy is a risk indicator of pre-eclampsia and eclampsia which augment infant and maternal morbidity and mortality. Magnesium deficiency has been related to the risk of hypertension. A study was performed to assess the relation between pregnancy induced hypertension, excretion of urinary magnesium and expression of magnesium sensitive genes (MgSG).
  
  
  METHODS
  A cohort of healthy, nulliparous women with singleton pregnancies was recruited. Blood pressure was recorded throughout pregnancy. Urinary magnesium excretion and expression of MgSGs in leukocytes were determined.
  
  
  RESULTS
  The expression of the gene TRPM6 was higher among pregnant women compared to non-pregnant controls at week 12. All other genes had lower expressions in pregnant women. At week 37 the expressions of all genes were lower than at week 12. The expressions of SLC41A1, SLC41A3, and TRPM7 were related to the systolic and diastolic blood pressures. Furthermore, the expression of TRPM6 was related to the urinary excretion of magnesium and the change in diastolic blood pressure weeks 12-37 was inversely related to the change in magnesium excretion.
  
  
  CONCLUSIONS
  Systolic and diastolic blood pressure and the excretion of magnesium during pregnancy were related to the expression of different MgSGs. The results suggest that magnesium is involved in the regulation of blood pressure during pregnancy.
authors.affiliation: Institute of Veterinary-Physiology, Freies Universität, Berlin, Germany; BioFact Environmental Health Research Center, Lerum, Sweden.
authors.forename: Axel
authors.initials: A
authors.lastname: Nestler
authors.affiliation: BioFact Environmental Health Research Center, Lerum, Sweden; Institute for Prevention and Nutrition, Ismaning/Munich, Germany. Electronic address: envhealth@biofact.se.
authors.forename: Ragnar
authors.initials: R
authors.lastname: Rylander
authors.affiliation: Institute of Veterinary-Physiology, Freies Universität, Berlin, Germany; BioFact Environmental Health Research Center, Lerum, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Kolisek
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg and Södra Älvsborgs Hospital, 501 82 Borås, Sweden.
authors.forename: Thorkild
authors.initials: T
authors.lastname: Nielsen
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg and Södra Älvsborgs Hospital, 501 82 Borås, Sweden.
authors.forename: Natalia
authors.initials: N
authors.lastname: Ödman
authors.affiliation: BioFact Environmental Health Research Center, Lerum, Sweden; Institute for Prevention and Nutrition, Ismaning/Munich, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Vormann
authors.affiliation: Department of Obstetrics and Gynaecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg and Södra Älvsborgs Hospital, 501 82 Borås, Sweden. Electronic address: maria.bullarbo@vgregion.se.
authors.forename: Maria
authors.initials: M
authors.lastname: Bullarbo
keywords: Magnesium; Magnesium sensitive genes; Pregnancy hypertension