title: Multiple sclerosis and Parkinson's disease: the two faces of neurodegeneration. Report of the first Greek case and review of the literature.
abstract: There is still an open debate whether multiple sclerosis (MS) lesions can cause parkinsonian symptoms, or the coexistence of both diseases in the same patient is accidental. Moreover, α-synuclein (α Syn), the hallmark of Parkinson's disease (PD) seems also to play a crucial role in MS. So far, 42 cases of co-occurrence of parkinsonism and MS have been reported, but CSF α Syn measurement is lacking. To our knowledge, we report the first case with concomitant MS and PD diagnosis based on both clinico-radiological and CSF α Syn findings and review of literature.
authors.affiliation: First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece. annita139@yahoo.gr.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Bougea
authors.affiliation: First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Kapaki
authors.affiliation: First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.
authors.forename: George P
authors.initials: GP
authors.lastname: Paraskevas
authors.affiliation: First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.
authors.forename: Kostas
authors.initials: K
authors.lastname: Kilidireas
authors.affiliation: First Department of Neurology, Aeginition Hospital, Medical School, National and Kapodistrian University, 72-74 Vasilissis Sofias Avenue, 11528, Athens, Greece.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Andreadou
mesh_terms: D001921:Brain / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000473:pathology*; D016896:Treatment Outcome; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid
chemical_list: D051844:alpha-Synuclein
keywords: Cerebrovascular liquid (CSF); Multiple sclerosis (MS); Neurodegeneration; Parkinson’s disease (PD); a-Synuclein (α Syn)