title: Simvastatin ameliorates low-dose streptozotocin-induced type 2 diabetic nephropathy in an experimental rat model.
abstract: The present study aims to study the possible renal protective effect of simvastatin in the development and progression of type 2 diabetic nephropathy. A rat model of T2DN was induced by high-fat diet together with single low-dose of streptozotocin. The diabetic rats were either given treatment or vehicle control for 13 weeks to develop nephropathy. At the end of treatment, parameters of renal function were determined. Kidney samples were collected for histological studies and generated homogenates for biochemical analysis. In T2DN rats, severe hyperglycemia was developed, FBG were markedly elevated. Diabetes induced significant alterations in renal structure, such as severe reduction of glomerular tufts, increase in Bowman's spaces, thickening of GBM. In addition, and SCr, UAER and BUN are elevated, accompanied with reduction in UCr and CCr, indicating obvious renal failure. On the other hand, endogenous antioxidants SOD, GSH-Px were reduced, whereas MDA was increased. However, treatment of T2DN rats with simvastatin restored renal changes in different aspects. Our results showed that STZ-induced T2DN could be attenuated by simvastatin. The renoprotective effects of simvastatin was indicated by improvements in kidney function parameters, and was attributed by its lipid-lowering effect as well as its anti-oxidative stress, anti-inflammatory properties without having noticeable influence on glycemic control. Simvastatin ameliorates low-dose Streptozotocin-induced type 2 diabetic nephropathy in an experimental rat model.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Siwei
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Huali
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Fanfan
authors.initials: F
authors.lastname: Sun
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University Changchun 130021, P. R. China.
authors.forename: Dayuan
authors.initials: D
authors.lastname: Sui
keywords: Simvastatin; oxidative stress; rat; type 2 diabetic nephropathy