title: Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions.
abstract: Neural synapses are intercellular asymmetrical junctions that transmit biochemical and biophysical information between a neuron and a target cell. They are very tight, dynamic, and well organized by many synaptic adhesion molecules, signaling receptors, ion channels, and their associated cytoskeleton that bear forces. Mechanical forces have been an emerging factor in regulating axon guidance and growth, synapse formation and plasticity in physiological and pathological brain activity. Therefore, mechanical forces are undoubtedly exerted on those synaptic molecules and modulate their functions. Here we review current progress on how mechanical forces regulate receptor-ligand interactions, protein conformations, ion channels activation, and cytoskeleton dynamics and discuss how these regulations potentially affect synapse formation, stabilization, and plasticity.
authors.affiliation: School of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Wei
authors.identifier: 0000-0003-3068-6333
authors.initials: W
authors.lastname: Hu
authors.affiliation: School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China.
authors.forename: Chenyi
authors.identifier: 0000-0002-2571-9594
authors.initials: C
authors.lastname: An
authors.affiliation: School of Medicine, Zhejiang University, Hangzhou 310058, China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China.
authors.forename: Wei J
authors.identifier: 0000-0001-5366-7253
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D001369:Axons / Q000473:pathology / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008024:Ligands; D055495:Neurogenesis; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D011487:Protein Conformation; D015398:Signal Transduction; D013569:Synapses / Q000473:pathology / Q000502:physiology*
chemical_list: D008024:Ligands