title: Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array.
abstract: Due to their low cost, hand-held convenience, wide selection of bandwidths, and ultrasound imaging capability, linear ultrasonic transducer arrays have been widely studied for photoacoustic computed tomography (PACT). As linear-array PACT suffers from a limited view, full-view imaging requires either the transducer or the object to be rotated. So far, both the central frequencies and bandwidth of linear transducer arrays applied in full-view PACT are low, limiting the spatial resolutions of the reconstructed images. Here, we present a multiview high-frequency PACT imaging system implemented with a commercial 40-MHz central frequency linear transducer array. By rotating the object through multiple angles with respect to the linear transducer array, we acquired full-view photoacoustic pressure measurements. Further, to quantify the unipolar initial pressures and overcome the limitations of the single-view Hilbert transformation, we developed a multiview Hilbert transformation method. The in-plane spatial resolution of this full-view linear-array PACT was quantified to be isotropically 60  μm within a 10×10  mm² field of view. The system was demonstrated by imaging both a leaf skeleton and a zebrafish in vivo.
authors.affiliation: Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Guo
authors.initials: G
authors.lastname: Li
authors.affiliation: Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Liren
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.affiliation: Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, One Brookings Drive, St. Louis, Missouri 63130, United States.
authors.forename: Lihong V
authors.initials: LV
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D008954:Models, Biological; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods*; D018515:Plant Leaves; D014057:Tomography, X-Ray Computed / Q000295:instrumentation* / Q000379:methods*; D014159:Transducers