title: Topical combination therapy with vitamin D3 and corticosteroid ointment for palmoplantar pustulosis: A prospective, randomized, left-right comparison study.
abstract: BACKGROUND
  Vitamin D3 ointment and corticosteroid ointment are both used for the treatment of palmoplantar pustulosis (PPP). However, to date there is no systematic study of the efficacy of combination therapy for the treatment of PPP.
  
  
  OBJECTIVE
  We compared the efficacy of a topical combination therapy with vitamin D3 and a topical corticosteroid with that of topical corticosteroid alone in the treatment of PPP.
  
  
  METHODS
  We evaluated left-right comparison study of the efficacy of a combination therapy consisting of maxacalcitol ointment and betamethasone butyrate propionate ointment (BBP), and monotherapy with BBP alone in 27 patients with PPP for 8 weeks.
  
  
  RESULTS
  The improvement in the symptom (erythema, pustules/vesicles, hyperkeratosis/scales) scores was high for the combination therapy. In particular, the improvement rate for pustules/vesicles at week 8 after the combination therapy was significantly higher than for the monotherapy (p < 0.05).
  
  
  CONCLUSIONS
  This combination regimen demonstrated that not only topical corticosteroids, but also topical vitamin D3 ointment, is useful for the treatment of PPP.
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Muro
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawakami
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Matsumoto
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Namiko
authors.initials: N
authors.lastname: Abe
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tsuboi
authors.affiliation: a Department of Dermatology , Tokyo Medical University , Tokyo , Japan.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Okubo
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D005938:Glucocorticoids; D009824:Ointments; D002117:Calcitriol; C051883:maxacalcitol
keywords: Betamethasone butyrate propionate ointment; maxacalcitol ointment; palmoplantar pustulosis