title: Juvenile Osteochondritis Dissecans: Correlation Between Histopathology and MRI.
abstract: OBJECTIVE
  The objective of our study was to correlate specimens of juvenile osteochondritis dissecans (OCD) lesions of the knee to MRI examinations to elucidate the histopathologic basis of characteristic imaging features.
  
  
  METHODS
  Five children (three boys and two girls; age range, 12-13 years old) who underwent transarticular biopsy of juvenile OCD lesions of the knee were retrospectively included in this study. Two radiologists reviewed the MRI examinations and a pathologist reviewed the histopathologic specimens and recorded characteristic features. Digital specimen photographs were calibrated to the size of the respective MR image with the use of a reference scale. Photographs were rendered semitransparent and over-laid onto the MR image with the location chosen on the basis of the site of the prior biopsy.
  
  
  RESULTS
  A total of seven biopsy specimens were included. On MRI, all lesions showed cystlike foci in the subchondral bone, bone marrow edema pattern on proton density-or T2-weighted images, and relatively thick unossified epiphyseal cartilage. In four patients, a laminar signal intensity pattern was seen, and two patients had multiple breaks in the subchondral bone plate. Fibrovascular tissue was found at histopathology in all patients. Cleft spaces near the cartilage-bone interface and were seen in all patients while chondrocyte cloning was present in most cases. Focal bone necrosis and inflammation were infrequent MRI findings. Precise correlation of the MRI appearance to the histopathologic overlays consistently was found.
  
  
  CONCLUSIONS
  A direct correlation exists between the histopathologic findings and the MRI features in patients with juvenile OCD. Additional studies are needed to correlate these MRI features with juvenile OCD healing success rates.
authors.affiliation: 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Zbojniewicz
authors.affiliation: 2 Department of Pathology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
authors.forename: Keith F
authors.initials: KF
authors.lastname: Stringer
authors.affiliation: 1 Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229.
authors.forename: Tal
authors.initials: T
authors.lastname: Laor
authors.affiliation: 3 Department of Orthopedics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Wall
mesh_terms: D001182:Arthroscopy; D001706:Biopsy; D002648:Child; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010008:Osteochondritis Dissecans / Q000473:pathology*; D012189:Retrospective Studies
keywords: MRI; knee; osteochondritis dissecans; pathology; pediatrics