title: Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oil from Spain: determination of aromatic profile by gas chromatography-mass spectrometry, antioxidant and lipoxygenase inhibitory bioactivities.
abstract: Lavandin (Lavandula × intermedia Emeric ex Loiseleur) essential oils (EOs), from Abrial, Super and Grosso cultivars, cultivated and extracted in the South East of Spain, were analysed by using GC/MS to determine their composition, in both relative (peak area) and absolute (using standard curves) concentrations. Linalool (34-47%), linalyl acetate (17-34%), camphor (4-9%) and eucalyptol (3-7%) were determined as the main molecules. This characterisation was completed with the enantioselective gas chromatography, where ( - )-linalool, (+)-camphor and ( - )-linalyl acetate were determined as the main components. Antioxidant activity was evaluated positively by several methods: activity against free radicals, chelating and reducing power, probably due to linalool and linalyl acetate. Mild inhibitory activity on lipoxygenase was observed supporting potential anti-inflammatory activity, mainly due to linalool and camphor. These properties support the potential use of L. × intermedia essential oils as natural cosmetic and natural pharmaceutical ingredient to fight several skin diseases.
authors.affiliation: a Department of Biochemistry and Molecular Biology-A , GENZ-Group of Research on Enzymology ( www.um.es/genz ),Faculty of Veterinary Science, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Espinardo 30100 , Murcia , Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Carrasco
authors.affiliation: b Novozymes Spain S.A. , Spain ( www.novozymes.com ).
authors.forename: Ramiro
authors.initials: R
authors.lastname: Martinez-Gutierrez
authors.affiliation: c Department of Analytical Chemistry , University of Murcia , Murcia , Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Tomas
authors.affiliation: a Department of Biochemistry and Molecular Biology-A , GENZ-Group of Research on Enzymology ( www.um.es/genz ),Faculty of Veterinary Science, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Espinardo 30100 , Murcia , Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Tudela
mesh_terms: D000080462:Acyclic Monoterpenes; D000975:Antioxidants / Q000302:isolation & purification*; D002164:Camphor / Q000302:isolation & purification; D003511:Cyclohexanols / Q000302:isolation & purification; D000077591:Eucalyptol; D008401:Gas Chromatography-Mass Spectrometry; D027523:Lavandula / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification*; D039821:Monoterpenes / Q000302:isolation & purification; D009822:Oils, Volatile / Q000737:chemistry*; D064209:Phytochemicals / Q000737:chemistry / Q000302:isolation & purification*; D013030:Spain
chemical_list: D000080462:Acyclic Monoterpenes; D000975:Antioxidants; D003511:Cyclohexanols; D016859:Lipoxygenase Inhibitors; D039821:Monoterpenes; D009822:Oils, Volatile; D064209:Phytochemicals; C074463:linalyl acetate; D002164:Camphor; C018584:linalool; D000077591:Eucalyptol
keywords: GC–MS; LOX inhibitory activity; Lavandula × intermedia; antioxidant; enantiomeric ratio; essential oil