title: The Effect of HLA-DRB1 on Cholecystitis.
abstract: BACKGROUND
  Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes.
  
  
  OBJECTIVE
  To determine the association between HLA-DRB1 and cholecystitis.
  
  
  METHODS
  This case-control study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP).
  
  
  RESULTS
  There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949).
  
  
  CONCLUSIONS
  HLA-DRB1*0301, as a genetic factor, seems to have an association with cholecystitis.
authors.affiliation: Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq, e-mail: Twfk66@yahoo.com.
authors.forename: Tawfik Jasim Mohammad
authors.initials: TJ
authors.lastname: Al-Marzook
authors.forename: Batool
authors.initials: B
authors.lastname: Mutar Mahdi
authors.forename: Hyam
authors.initials: H
authors.lastname: Raouf
authors.forename: Haider Hashim
authors.initials: HH
authors.lastname: Zalzala
authors.forename: Laheeb Ali
authors.initials: LA
authors.lastname: Abid
authors.forename: Zena
authors.initials: Z
authors.lastname: Nehad
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002763:Cholecystectomy; D002764:Cholecystitis / Q000276:immunology* / Q000601:surgery; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007493:Iraq; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D059811:HLA-DRB1 Chains; C553502:HLA-DRB1*03:01 antigen