title: Squamous cell carcinoma originating from cutaneous cysts: The Henry Ford Experience and review of the literature.
abstract: OBJECTIVE
  Malignant transformation to squamous cell carcinoma (SCC) arising within cutaneous epidermal cysts is a very rare phenomenon. We provide a series of new cases and an overview of the literature. We sought to define the prevalence of and characterize SCC arising within epidermal and pilar cysts.
  
  
  METHODS
  We searched Henry Ford Health System (HFHS) non-melanoma skin cancer (NMSC) registry from 2005 to 2009 to identify cases of SCC arising from epidermal cysts.
  
  
  RESULTS
  We identified 1904 cases of epidermal cysts at our institution between 2005 and 2014. Of these, three cases of SCC arose from an epidermal cyst and one case of SCC developed from a pilar cyst. All lesions occurred below the waist with the exception of the pilar cyst on the scalp.
  
  
  CONCLUSIONS
  Given the extremely low incidence, propensity of malignant lesions to become symptomatic and efficacy of treatment, we do not recommend routine excision of all epidermal cysts. Instead, we recommend excision and pathology for all symptomatic epidermal cysts, or those that rapidly grow, or do not respond to medical therapy.
authors.affiliation: a Department of Oncology , Wayne State University School of Medicine , Detroit , MI , USA .
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Veenstra
authors.affiliation: b Department of Dermatology , Henry Ford Hospital , Detroit , MI , USA , and.
authors.forename: Samreen
authors.initials: S
authors.lastname: Choudhry
authors.affiliation: c Department of Public Health Sciences , Henry Ford Hospital , Detroit , MI , USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Krajenta
authors.affiliation: b Department of Dermatology , Henry Ford Hospital , Detroit , MI , USA , and.|c Department of Public Health Sciences , Henry Ford Hospital , Detroit , MI , USA.
authors.forename: Melody J
authors.initials: MJ
authors.lastname: Eide
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D004814:Epidermal Cyst / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology
keywords: Case series; epidermal cyst; literature review; pilar cyst; squamous cell carcinoma