title: Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions.
abstract: Lucilia cuprina is a parasitic fly of major economic importance worldwide. Larvae of this fly invade their animal host, feed on tissues and excretions and progressively cause severe skin disease (myiasis). Here we report the sequence and annotation of the 458-megabase draft genome of Lucilia cuprina. Analyses of this genome and the 14,544 predicted protein-encoding genes provide unique insights into the fly's molecular biology, interactions with the host animal and insecticide resistance. These insights have broad implications for designing new methods for the prevention and control of myiasis.
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Clare A
authors.initials: CA
authors.lastname: Anstead
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Pasi K
authors.initials: PK
authors.lastname: Korhonen
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Young
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Ross S
authors.initials: RS
authors.lastname: Hall
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Jex
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Shwetha C
authors.initials: SC
authors.lastname: Murali
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Daniel S T
authors.initials: DS
authors.lastname: Hughes
authors.affiliation: School of Biosciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Siu F
authors.initials: SF
authors.lastname: Lee
authors.affiliation: School of Biosciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Trent
authors.initials: T
authors.lastname: Perry
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Stroehlein
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Brendan R E
authors.initials: BR
authors.lastname: Ansell
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Bert
authors.initials: B
authors.lastname: Breugelmans
authors.affiliation: Structural Chemistry Program, Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Queensland 4111, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hofmann
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Dugan
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Lee
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Hsu
authors.initials: H
authors.lastname: Chao
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Huyen
authors.initials: H
authors.lastname: Dinh
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Harsha V
authors.initials: HV
authors.lastname: Doddapaneni
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Kim C
authors.initials: KC
authors.lastname: Worley
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Donna M
authors.initials: DM
authors.lastname: Muzny
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva &Swiss Institute of Bioinformatics, CH-1211 Geneva, Switzerland.
authors.forename: Panagiotis
authors.identifier: 0000000309396745
authors.initials: P
authors.lastname: Ioannidis
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva &Swiss Institute of Bioinformatics, CH-1211 Geneva, Switzerland.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Waterhouse
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva &Swiss Institute of Bioinformatics, CH-1211 Geneva, Switzerland.
authors.forename: Evgeny M
authors.initials: EM
authors.lastname: Zdobnov
authors.affiliation: Ecosciences Precinct, Queensland Alliance for Agriculture and Food Innovation (QAAFI), Queensland Bioscience Precinct, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: James
authors.affiliation: CSIRO Agriculture Flagship, Queensland Bioscience Precinct, St Lucia, Brisbane, Queensland 4067, Australia.
authors.forename: Neil H
authors.initials: NH
authors.lastname: Bagnall
authors.affiliation: CSIRO Agriculture Flagship, Queensland Bioscience Precinct, St Lucia, Brisbane, Queensland 4067, Australia.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Kotze
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gibbs
authors.affiliation: Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Richards
authors.affiliation: School of Biosciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: Batterham
authors.affiliation: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D000818:Animals; D004175:Diptera / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D049750:Genome, Insect; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D007305:Insecticide Resistance / Q000235:genetics; D007306:Insecticides / Q000494:pharmacology; D007814:Larva; D008297:Male; D059467:Transcriptome
chemical_list: D019476:Insect Proteins; D007306:Insecticides