title: [DNA mismatch repair and BRAF status in colorectal cancer: Interest for the therapeutic management?].
abstract: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in France. Recently, colorectal cancer subtyping consortium (CRCSC) identified 4 consensus molecular subtypes (CMS). CMS1 is enriched for CRC with deficient DNA mismatch repair system (dMMR) and tumors with mutated BRAF. Intriguingly, CMS1 is characterized by better relapse-free survival but worse survival after relapse, compared with the other subtypes. In this review, we provide a comprehensive overview of prognostic and predictive impacts of MMR and BRAF status. We highlight immune checkpoints inhibitors as potentially future therapeutics for CRC with deficient MMR. We also focus on the management of BRAF mutant metastatic CRC, with a particular interest on targeted therapies.
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France; Groupe coopérateur multidisciplinaire en oncologie (GERCOR), Paris, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Cohen
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Cervera
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France; Inserm, Unité mixte de recherche scientifique 938, Centre de recherche Saint-Antoine, Équipe Instabilité des microsatellites et cancers, Équipe labellisée par la Ligue nationale contre le cancer, Paris, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Svrcek
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Dumont
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: Marie-Line
authors.initials: ML
authors.lastname: Garcia
authors.affiliation: Groupe coopérateur multidisciplinaire en oncologie (GERCOR), Paris, France; Institut hospitalier franco-britannique, 4 rue Kléber, 92300 Levallois-Perret, France.
authors.forename: Benoist
authors.initials: B
authors.lastname: Chibaudel
authors.affiliation: Groupe coopérateur multidisciplinaire en oncologie (GERCOR), Paris, France; Institut hospitalier franco-britannique, 4 rue Kléber, 92300 Levallois-Perret, France.
authors.forename: Aimery
authors.initials: A
authors.lastname: de Gramont
authors.affiliation: Hôpital Lariboisière, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, CART, Inserm U965, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Pocard
authors.affiliation: Inserm, Unité mixte de recherche scientifique 938, Centre de recherche Saint-Antoine, Équipe Instabilité des microsatellites et cancers, Équipe labellisée par la Ligue nationale contre le cancer, Paris, France.
authors.forename: Alex
authors.initials: A
authors.lastname: Duval
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France; Université Pierre et Marie Curie (UPMC), Paris VI, Paris, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Fléjou
authors.affiliation: Service d'oncologie médicale, Hôpitaux universitaires de l'Est Parisien (AP-HP), Site Saint-Antoine 184, rue du Faubourg Saint-Antoine, 75571 Paris cedex 12, France; Université Pierre et Marie Curie (UPMC), Paris VI, Paris, France. Electronic address: thierry.andre@sat.aphp.fr.
authors.forename: Thierry
authors.initials: T
authors.lastname: André
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D043171:Chromosomal Instability; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D053843:DNA Mismatch Repair; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D000077150:Oxaliplatin; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D048493:Proto-Oncogene Proteins B-raf
keywords: Adjuvant treatment; BRAF; Cancer colorectal; Colorectal cancer; Mismatch repair system; Statut microsatellite; Targeted therapies; Thérapies ciblées; Traitement adjuvant