title: Synthesis and characterization of silane coated magnetic nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a drug carrier for the controlled delivery of 5-fluorouracil.
abstract: A novel drug delivery system (DDS), 3-methacryloxypropyl trimethoxy silane coated magnetic nanoparticles polymerized with glycidylmethacrylate-grafted-maleated cyclodextrin (MPTMS-MNP-poly-(GMA-g-MACD)) was prepared in the presence of ethyleneglycoldimethacrylate as cross-linker and a,a'-azobisisobutyronitrile as initiator and characterized by means of SEM, FT-IR, XRD, DLS, VSM and TEM. The encapsulation efficiency (EE) and drug loading efficiency (DLE) of the DDS were tested using various formulations of DDS. The DDS showed activity against gram positive and negative bacteria. The cytotoxicity studies were also performed using MCF-7 (human breast carcinoma) cells and found that the drug carrier is biocompatible and it shows sustained and controlled release of drug to the targeted site. The drug release mechanism was found to obey non-Fickian diffusion (n=0.709) method where polymer relaxation and drug diffusion played important roles in drug release. In this DDS, advantages of core magnetic nanoparticles and host-guest interactions of β-CD were combined for the controlled delivery of 5-Fluorouracil (5-FU) to maintain the therapeutic index of the drug.
authors.affiliation: Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India. Electronic address: tsani@rediffmail.com.
authors.forename: Thayyath S
authors.initials: TS
authors.lastname: Anirudhan
authors.affiliation: Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India.
authors.forename: Peethambaran L
authors.initials: PL
authors.lastname: Divya
authors.affiliation: Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom, Trivandrum 695 581, India.
authors.forename: Jayachandran
authors.initials: J
authors.lastname: Nima
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D005472:Fluorouracil / Q000008:administration & dosage*; D020100:Hydrogels; D008280:Magnetics; D008689:Methacrylates / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D012821:Silanes / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D020099:Coated Materials, Biocompatible; D003505:Cyclodextrins; D004337:Drug Carriers; D020100:Hydrogels; D008689:Methacrylates; D012821:Silanes; D005472:Fluorouracil
keywords: 5-Fluorouracil; Controlled drug delivery; Cyclodextrin; Cytotoxicity; Graft polymers; Magnetic nanoparticles