title: Methionine sulfoxide reductase A (MsrA) associated with bipolar I disorder and executive functions in A Han Chinese population.
abstract: BACKGROUND
  The oxidative stress hypothesis proposed to explain bipolar I disorder (BD I) pathogenesis has gained growing attention based on its association with cognitive impairment. The aim of the present study was to explore the association of the methionine sulfoxide reductase A (MsrA) gene with BD I as well as executive functions of BD I patients.
  
  
  METHODS
  A total of 44 tagging single-nucleotide polymorphisms within the MsrA gene were selected to analyze gene association with BD I in 375 BD I patients and 475 controls in a Han Chinese population. The association of MsrA haplotypes with executive functions was analyzed in 157 clinically stable BD I patients and 210 controls.
  
  
  RESULTS
  Allele frequencies of the rs4840463 polymorphism were significantly different between BD I patients and controls, and between patients with psychotic symptoms and controls. BD I patients performed more poorly in 11 of the 13 neurocognitive measurements compared with controls. Three MsrA haplotypes showed significant associations with different executive functions.
  
  
  CONCLUSIONS
  The limited sample size requires a cautious conclusion, and further comprehensive approaches are needed to explore the mechanism of MsrA's effect on BD I.
  
  
  CONCLUSIONS
  The rs4840463 polymorphism in the MsrA gene may be associated with the increased risk of BD I in a Chinese population. The association of MsrA haplotypes with executive functions indicated that MsrA is associated with executive function defects in BD I patients.
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Peiyan
authors.initials: P
authors.lastname: Ni
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: maxiaohong@scu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Guohui
authors.initials: G
authors.lastname: Lao
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Hao
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Guan
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China.
authors.forename: Biyu
authors.initials: B
authors.lastname: Ye
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China. Electronic address: coolliping@hotmail.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.affiliation: Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D002681:China; D056344:Executive Function; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D051150:Methionine Sulfoxide Reductases / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055815:Young Adult
chemical_list: D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase
keywords: Bipolar I disorder (BD I); Executive functions; Methionine sulfoxide reductase A (MsrA); Psychotic symptoms