title: Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis.
abstract: Actinic keratoses are premalignant lesions of the skin caused by excessive sun exposure. Lesions may become mainly squamous cell carcinoma. Cryotherapy with liquid nitrogen is one of the main treatments. In order to evaluate the response of actinic keratosis to cryotherapy by histopathology, two lesions were selected in each of 14 patients with multiple actinic keratoses. In one lesion a biopsy was performed and in the other lesion a biopsy was performed after cryotherapy. Subsequently, both biopsies were compared histologically. Of the thirteen patients who completed the study, the best results were obtained in lesions undergoing cryotherapy concerning the atypia of keratinocytes, epithelial thickness and corneal layer and lymphocytic infiltrate. Despite the small number of patients, it was concluded that, if performed correctly, cryotherapy has high efficacy in the treatment of actinic keratoses.
authors.affiliation: Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
authors.forename: Marina Câmara de
authors.initials: MC
authors.lastname: Oliveira
authors.affiliation: Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Trevisan
authors.affiliation: Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
authors.forename: Clovis Antônio Lopes
authors.initials: CA
authors.lastname: Pinto
authors.affiliation: Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
authors.forename: Célia Antônia
authors.initials: CA
authors.lastname: Xavier
authors.affiliation: Faculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
authors.forename: Jaqueline Campoi Calvo Lopes
authors.initials: JC
authors.lastname: Pinto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003315:Cornea / Q000473:pathology; D017679:Cryotherapy / Q000379:methods*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D055623:Keratosis, Actinic / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000627:therapeutic use*; D015203:Reproducibility of Results; D012867:Skin / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D009584:Nitrogen