title: Neuromuscular disorders and sleep in critically ill patients.
abstract: Sleep-disordered breathing (SDB) is a frequent presenting manifestation of neuromuscular disorders and can lead to significant morbidity and mortality. If not recognized and addressed early in the clinical course, SDB can lead to clinical deterioration with respiratory failure. The pathophysiologic basis of SDB in neuromuscular disorders, clinical features encountered in specific neuromuscular diseases, and diagnostic and management strategies for SDB in neuromuscular patients in the critical care setting are reviewed. Noninvasive positive pressure ventilation has been a crucial advance in critical care management, improving sleep quality and often preventing or delaying mechanical ventilation and improving survival in neuromuscular patients.
authors.affiliation: Department of Medicine, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Neurology, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Muna
authors.initials: M
authors.lastname: Irfan
authors.affiliation: Department of Medicine, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Selim
authors.affiliation: Department of Neurology, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA.
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Rabinstein
authors.affiliation: Department of Medicine, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Neurology, Mayo Center for Sleep Medicine, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: StLouis.Erik@mayo.edu.
authors.forename: Erik K
authors.initials: EK
authors.lastname: St Louis
mesh_terms: D016638:Critical Illness; D006801:Humans; D007040:Hypoventilation; D009468:Neuromuscular Diseases / Q000150:complications* / Q000503:physiopathology; D012121:Respiration, Artificial; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000401:mortality; D012893:Sleep Wake Disorders / Q000209:etiology*
keywords: Critical care; Intensive care unit; Management; Neuromuscular disorders; Sleep; Sleep disorders