title: The high-affinity immunoglobulin E receptor as pharmacological target.
abstract: The high-affinity receptor for immunoglobulin E is expressed mainly on mast cells and basophils, but also on neutrophils, eosinophils, platelets, monocytes, Langerhans and dendritic cells, airway smooth muscle cells and some nerve cells. Its main function is, upon its engagement by IgE and specific antigen, to trigger a powerful defense against invading pathogens and a rapid neutralization of dangerous toxic substances introduced in the body. This powerful response could be wielded against tumors. But, when control over this receptor is lost, its unchecked activation can induce an array of diseases, some of which can lead to death. In this review we will summarize the pharmacological approaches and strategies that are currently used, or under study, to harness or wield activation of this receptor for therapeutic purposes.
authors.affiliation: Inserm U1149 and CNRS ERL 8252, Labex Inflamex, Université Paris Diderot - Faculté de Médecine, site Bichat, 16, rue Henri Huchard, 75018 Paris, France. Electronic address: ulrich.blank@inserm.fr.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Blank
authors.affiliation: Inserm U1149 and CNRS ERL 8252, Labex Inflamex, Université Paris Diderot - Faculté de Médecine, site Bichat, 16, rue Henri Huchard, 75018 Paris, France. Electronic address: nicolas.charles@inserm.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Charles
authors.affiliation: Inserm U1149 and CNRS ERL 8252, Labex Inflamex, Université Paris Diderot - Faculté de Médecine, site Bichat, 16, rue Henri Huchard, 75018 Paris, France. Electronic address: marc.benhamou@inserm.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Benhamou
mesh_terms: D000818:Animals; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D017455:Receptors, IgE / Q000378:metabolism*
chemical_list: D017455:Receptors, IgE
keywords: Allergy; Auto-immune diseases; Cancer; High-affinity receptor for IgE