title: Effects of interleukin-2 on bioelectric activity of rat atrial myocardium under normal conditions and during gradual stretching.
abstract: Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90% re-polarization. Perfusion with interleukin-2 resulted in appearance of frequent rhythm patterns followed by smooth transient fragments of paroxysmal tachyarrhythmia pacing into normal rhythms. In the presence of interleukin-2, stretching of the tissue by 1.7 mN led to appearance of abnormal bio-electrical activity, predominantly in the lengthening of the duration of action potential at the levels of 90% re-polarization. Close observation of both interleukin-2 induced action potential duration to 90% of re-polarization, hump-like depolarization and stretch induced hump-like alteration, indicate existence of a link between the interleukin-2 and stretch induced mechanisms.
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Aksyonov
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia. Electronic address: vmitrohin@gmail.com.
authors.forename: V M
authors.initials: VM
authors.lastname: Mitrokhin
authors.affiliation: Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia; Faculty of Natural Sciences and Mathematics, Institute of Biology, "Sts, Cyril and Methodius" University, P.O. Box 162, Skopje 1000, Macedonia. Electronic address: m.mitko@gmail.com.
authors.forename: M I
authors.initials: MI
authors.lastname: Mladenov
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function / Q000187:drug effects* / Q000502:physiology*; D055724:Electrophysiological Phenomena / Q000187:drug effects; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects; D051381:Rats; D013610:Tachycardia
chemical_list: D007376:Interleukin-2
keywords: Action potential; Atrium; Heart; Interleukin 2; Stretch