title: Use of sugammadex on burn patients: descriptive study.
abstract: OBJECTIVE
  A burn patient is a challenge for any anesthesiologist, undergoing several surgeries during admission, and requiring general anesthesia and muscle relaxation most of the times. The victim may have respiratory system impairment and a response to muscle relaxants that differs from the healthy patient, thus proper monitoring and reversal is crucial. We analyzed sugammadex effectiveness and safety in this population.
  
  
  METHODS
  It was a prospectively descriptive study, including 4 patients, and all of them were considered major burn patients, who underwent escharotomy with general anesthesia and neuromuscular relaxation. The main variable was the time for recovery of a TOF higher than 0.9 after the administration of sugammadex before extubation.
  
  
  RESULTS
  Mean time of recovery from a TOF ratio higher than 0.9 following the administration of Sugammadex was of 4.95min 95% CI (3.25-6.64, p=.53).
  
  
  CONCLUSIONS
  The reversion of neuromuscular relaxation with sugammadex appears to be effective and safe in the burn patient. More analytical, comparative studies of larger populations would be necessary to confirm these data.
authors.affiliation: Anesthesiology and Reanimation, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. Electronic address: edurodriguez87@yahoo.es.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodríguez Sánchez M
authors.affiliation: Anesthesiology and Reanimation, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain.
authors.forename: Concepción
authors.initials: C
authors.lastname: Martínez Torres
authors.affiliation: Anesthesiology and Reanimation, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Herrera Calo
authors.affiliation: Anesthesiology and Reanimation, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Jiménez
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D002056:Burns / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D061886:Neuromuscular Monitoring / Q000379:methods; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D011446:Prospective Studies; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex
keywords: Bloqueio neuromuscular; Burn injury; Cyclodextrin; Gama-Ciclodextrinas; Neostigmina; Neostigmine; Neuromuscular block; Queimaduras; Rocuronium; Rocurônio; Sugammadex