title: Hepatitis E virus infection in Brazil: results of laboratory-based surveillance from 1998 to 2013.
abstract: BACKGROUND
  Data on hepatitis E virus (HEV) in Brazil are limited. We analyzed 15 years of HEV surveillance data in a major clinical laboratory in São Paulo, Brazil.
  
  
  METHODS
  The seroprevalence of HEV of 2,271 patients subjected to anti-HEV tests from 1998 to 2013 were analyzed.
  
  
  RESULTS
  HEV seroprevalence was 2.1%, and the anti-HEV IgM positivity rate was 4.9%. Six hepatitis E patients were identified.
  
  
  CONCLUSIONS
  HEV seroprevalence and detection rates appear to have increased in recent years. Hepatitis E should be investigated further and included in the differential diagnosis of hepatitis in Brazil.
authors.affiliation: Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, BR.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Passos-Castilho
authors.affiliation: Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, BR.
authors.forename: Anne
authors.initials: A
authors.lastname: de Sena
authors.affiliation: Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, BR.
authors.forename: Mônica Renata
authors.initials: MR
authors.lastname: Reinaldo
authors.affiliation: Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, BR.
authors.forename: Celso Francisco Hernandes
authors.initials: CF
authors.lastname: Granato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis / Q000453:epidemiology*; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral