title: Effectiveness and tolerability of short course co-trimoxazole, norfloxacin and levofloxacin in bacteriological cure of uncomplicated urinary tract infection in outpatient setting. An open label, parallel group, randomized controlled trial.
abstract: To compare the bacteriological cure rate of short-course (3-day) treatment of uncomplicated urinary tract infection (UTI) using co-trimoxazole, norfloxacin and levofloxacin, patients with uncomplicated UTI were randomized to receive either co-trimoxazole (960 mg) twice a day or norfloxacin (400 mg) twice a day or levofloxacin (250 mg) once a day for three days. Urine culture was done at the end of treatment and evaluated for bacteriological cure rate in each group. Among a total of 175 patients, Escherichia coli (74.29%) was the most common organism isolated followed by Klebsiella (11.43%), Streptococcus (6.29%), Staphylococcus saphrophyticus (5.14%), and Pseudomonas (2.86%). At the end of three days' treatment, bacteriological cure rates were 86.2%, 87.7% and 83.3% for co-trimoxazole, norfloxacin and levofloxacin, respectively (p>0.05). Therefore short-course treatment with co-trimoxazole 960 mg twice a day, norfloxacin 400 mg twice a day and levofloxacin 250 mg once a day are almost equally effective for treatment of uncomplicated UTI.
authors.affiliation: Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
authors.forename: Arpit Vallabhbhai
authors.initials: AV
authors.lastname: Vachhani
authors.affiliation: Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Barvaliya
authors.affiliation: Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
authors.forename: Viren
authors.initials: V
authors.lastname: Naik
authors.affiliation: Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Jha
authors.affiliation: Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
authors.forename: Chandrabhanu
authors.initials: C
authors.lastname: Tripathi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007194:India; D064704:Levofloxacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use*; D010045:Outpatients; D013997:Time Factors; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009643:Norfloxacin