title: Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers.
abstract: A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0-7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.
authors.affiliation: UNAM-National Nanotechnology Research Center, Bilkent University, Ankara, TR-06800, Turkey. eua@fen.bilkent.edu.tr.
authors.forename: Sundus
authors.initials: S
authors.lastname: Erbas-Cakmak
authors.forename: Fatma Pir
authors.initials: FP
authors.lastname: Cakmak
authors.forename: Seda Demirel
authors.initials: SD
authors.lastname: Topel
authors.forename: Taha Bilal
authors.initials: TB
authors.lastname: Uyar
authors.forename: Engin U
authors.initials: EU
authors.lastname: Akkaya