title: β-2 Adrenergic receptor gene polymorphism and response to propranolol in cirrhosis.
abstract: OBJECTIVE
  To evaluate the association of β-2 adrenergic receptor (β2-AR) gene polymorphism with response of variceal pressure to propranolol in cirrhosis.
  
  
  METHODS
  Sixty-four non-related cirrhotic patients participated in this study and accepted variceal pressure measurement before and after propranolol administration. Polymorphism of the β2-AR gene was determined by directly sequencing of the polymerase chain reaction products from the DNA samples that were prepared from the patients.
  
  
  RESULTS
  The prevalence of Gly16-Glu/Gln27 and Arg16-Gln27 homozygotes, and compound heterozygotes was 29.7%, 10.9%, and 59.4%, respectively. Patients with cirrhosis with Gly16-Glu/Gln27 homozygotes had a greater decrease of variceal pressure after propranolol administration than those with Arg16-Gln27 homozygotes or with compound heterozygotes (22.4% ± 2.1%, 13.1% ± 2.7% and 12.5% ± 3.1%, respectively, P < 0.01).
  
  
  CONCLUSIONS
  The variceal pressure response to propranolol was associated with polymorphism of β2-AR gene. Patients with the Gly(16)-Glu/Gln(27) homozygotes probably benefit from propranolol therapy.
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: De-Run
authors.initials: DR
authors.lastname: Kong
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Jin-Guang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Ming-Quan
authors.initials: MQ
authors.lastname: Wang
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yu
authors.affiliation: De-Run Kong, Jin-Guang Wang, Bin Sun, Chen Chen, Fang-Fang Yu, Jian-Ming Xu, Department of Gastroenterology, the first Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010597:Pharmacogenetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D011433:Propranolol / Q000627:therapeutic use*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: C553443:ADRB2 protein, human; D000319:Adrenergic beta-Antagonists; D018343:Receptors, Adrenergic, beta-2; D014665:Vasodilator Agents; D011433:Propranolol
keywords: Homozygotes; Propranolol; Variceal bleeding; Variceal pressure; β2-adrenergic receptor