title: Drug-induced skin reactions: a pathologist viewpoint.
abstract: Cutaneous drug reactions are common adverse effects that occur in about 2-3% of the hospitalized patients. They have both immunologic and non-immunologic underlying mechanisms. These reactions are clinically and histologically similar to dermatoses. Their significant clinical indicators include: history of drug intake, atypical clinical features and improvement after cessation of the offending drugs. Their diagnostic histological clues include the presence of mixed histological patterns, apoptotic keratinocytes, eosinophils (dermis and epidermis), papillary dermal edema and extravasations of erythrocytes. However, no single clinical or histological feature is specific of drug eruptions. This work attempts to classify the histomorphologic reactions to various drugs in defined categories for assistance in morphologic diagnosis.
authors.affiliation: a Department of Pathology, Faculty of Medicine , Assuit University Hospitals, Assuit University , Assuit , Egypt.
authors.forename: Mahmoud Rezk Abdelwahed
authors.initials: MR
authors.lastname: Hussein
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions; D006099:Granuloma / Q000139:chemically induced; D006801:Humans; D012871:Skin Diseases / Q000139:chemically induced*; D014657:Vasculitis / Q000139:chemically induced
keywords: Drug; eruptions; medications; reactions; skin