title: Opposing Roles of Dectin-1 Expressed on Human Plasmacytoid Dendritic Cells and Myeloid Dendritic Cells in Th2 Polarization.
abstract: Dendritic cells (DCs) can induce and control host immune responses. DC subset-dependent functional specialties and their ability to display functional plasticity, which is mainly driven by signals via pattern recognition receptors, identify DCs as immune orchestrators. A pattern recognition receptor, Dectin-1, is expressed on myeloid DCs and known to play important roles in Th17 induction and activation during fungal and certain bacterial infections. In this study, we first demonstrate that human plasmacytoid DCs express Dectin-1 in both mRNA and protein levels. More interestingly, Dectin-1-activated plasmacytoid DCs promote Th2-type T cell responses, whereas Dectin-1-activated myeloid DCs decrease Th2-type T cell responses. Such contrasting outcomes of Th2-type T cell responses by the two DC subsets are mainly due to their distinct abilities to control surface OX40L expression in response to β-glucan. This study provides new insights for the regulation of host immune responses by Dectin-1 expressed on DCs.
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: HyeMee
authors.initials: H
authors.lastname: Joo
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, Institute for Biomedical Studies, Waco, TX 76706; and.
authors.forename: Katherine
authors.initials: K
authors.lastname: Upchurch
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Ling
authors.initials: L
authors.lastname: Ni
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Dapeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Yaming
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Li
authors.affiliation: College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hori
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Sandra
authors.initials: S
authors.lastname: Zurawski
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, Institute for Biomedical Studies, Waco, TX 76706; and.
authors.forename: Gerard
authors.initials: G
authors.lastname: Zurawski
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204; Baylor University, Institute for Biomedical Studies, Waco, TX 76706; and sangkono@baylorhealth.edu.
authors.forename: SangKon
authors.initials: S
authors.lastname: Oh
mesh_terms: D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007156:Immunologic Memory; D009980:Influenza A virus / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*; D053278:OX40 Ligand / Q000378:metabolism; D014066:Palatine Tonsil / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D000072377:Syk Kinase; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism*; D047071:beta-Glucans / Q000378:metabolism; D000099181:Dectin-1
chemical_list: D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D037181:Lectins, C-Type; D053278:OX40 Ligand; D011505:Protein-Tyrosine Kinases; D012333:RNA, Messenger; D000072377:Syk Kinase; D047071:beta-Glucans; D000099181:Dectin-1; C064197:beta-1,6-glucan; C000606896:SYK protein, human