title: Reliability of the INSTI® rapid test for the diagnosis of HIV-1 non-B subtypes and recombinant variants.
abstract: Data regarding the efficacy of Rapid HIV tests (RHTs) in detecting non-B subtype HIV-1 are limited. We evaluated the sensitivity of the INSTI® test for the detection of HIV-1 antibodies for the diagnosis of HIV-1 non-B subtypes and recombinant variants. We identified adults with HIV-1 infection due to non-B subtypes and recombinant variants. The participants were re-tested with INSTI® test. We included 258 patients. Overall, the INSTI® test sensitivity was 98.4% (95%CI: 96.9-99.9%). For the major CRF_02AG subtype, the sensitivity was 99.0% (95%CI: 97.1-100%). The HIV INSTI® test is reliable for the detection of various non-B HIV-1 antibodies.
authors.affiliation: Service des Maladies Infectieuses, CHR Orléans, Orléans, France.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Goupil de Bouillé
authors.affiliation: Service des Maladies Infectieuses, CHU La Milétrie, Poitiers, France.
authors.forename: Gwénaël
authors.initials: G
authors.lastname: Le Moal
authors.affiliation: Service des Maladies Infectieuses, CHR Orléans, Orléans, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Hocqueloux
authors.affiliation: Laboratoire de Virologie, CHR Orléans, Orléans, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Guigon
authors.affiliation: Service des Maladies Infectieuses, CHU La Milétrie, Poitiers, France.
authors.forename: David
authors.initials: D
authors.lastname: Plainchamp
authors.affiliation: Laboratoire de Virologie, CHU La Milétrie, Poitiers, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Giraudeau
authors.affiliation: Service des Maladies Infectieuses, CHR Orléans, Orléans, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Theillay
authors.affiliation: Service des Maladies Infectieuses, CHR Orléans, Orléans, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Languille
authors.affiliation: Laboratoire de Virologie, Hôpital Européen Georges Pompidou, and Université Paris Descartes, Paris Sorbonne Cité, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Bélec
authors.affiliation: Service des Maladies Infectieuses, CHR Orléans, Orléans, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Prazuck
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1 / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011995:Recombination, Genetic; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods*
chemical_list: D015483:HIV Antibodies
keywords: HIV Subtype; circulating recombinant form; diagnosis capillary blood test; non-B subtype; rapid HIV test