title: Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.
abstract: BACKGROUND
  Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD.
  
  
  METHODS
  Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method.
  
  
  RESULTS
  Distribution of DRD3 and CNR1 polymorphism was not different between patients and controls.
  
  
  CONCLUSIONS
  These findings do not support a major role of DRD3, and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Yıldız
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Vural
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Erdal
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Özlem
authors.initials: Ö
authors.lastname: İzci Ay
authors.affiliation: Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
authors.forename: Şenay Görücü
authors.initials: ŞG
authors.lastname: Yılmaz
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: İbrahim Fatih
authors.initials: İF
authors.lastname: Karababa
authors.affiliation: Department of Psychiatry &Behavıoral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
keywords: Cannabinoid receptor; Dopamine D3 receptor; Genetic polymorphism; Premenstrual syndrome