title: The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses.
abstract: Herpesviruses are unusual among enveloped viruses because they bud twice yet acquire a single envelope. They are also the only known viruses that bud into the nuclear envelope. We discovered that the herpesvirus nuclear egress complex could bud membranes without the help of other proteins by forming a coat-like hexagonal scaffold inside the budding membrane. This finding raises the possibility that a phenotypically similar nuclear export of large RNAs is cargo driven.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Janna M
authors.initials: JM
authors.lastname: Bigalke
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA katya.heldwein@tufts.edu.
authors.forename: Ekaterina E
authors.initials: EE
authors.lastname: Heldwein
mesh_terms: D000818:Animals; D006564:Herpesviridae / Q000502:physiology*; D006801:Humans; D009685:Nuclear Envelope / Q000378:metabolism / Q000821:virology*; D057074:Virus Release / Q000502:physiology*