title: LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study.
abstract: BACKGROUND
  Nasal NK/T-cell lymphoma is a rare type of lymphoma in Caucasian individuals, but is relatively common in Asian populations. Genetic variants in immune and inflammatory response genes may thus be associated with the risk of developing lymphoma. Here, we investigated the association between immuno-modulatory gene polymorphisms and risk for nasal NK/T-cell lymphoma in a Chinese population.
  
  
  METHODS
  Analysis of 12 single nucleotide polymorphisms (SNPs) in IL-10, TNF-α, lymphotoxin-α (LTA), and CTLA-4 genes was performed for 125 patients with NK/T-cell lymphoma and 300 healthy controls by PCR-ligase detection reactions.
  
  
  RESULTS
  The LTA +252 GA + AA genotypes were associated with increased risk for NK/T-cell lymphoma (OR = 2.96, 95 % CI = 1.42-6.19, P = 0.004 for GA + AA genotype). Haplotype C-G-G-A (TNF-α -857, -308, -238 and LTA +252) also conferred an increased risk (OR = 1.52, 95% CI = 1.14-2.06, P = 0.005). Additionally, the LTA +252 GA + AA genotype was associated with an even higher risk in populations positive for Epstein-Barr virus (OR = 5.20, 95% CI = 1.22-23.41, P = 0.03 for the GA + AA genotype).
  
  
  CONCLUSIONS
  Our data suggest that the LTA +252 A > G polymorphism is associated with the risk of developing NK/T-cell lymphoma, especially for Epstein-Barr virus-positive NK/T-cell lymphoma in the Chinese population.
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. chsensen@163.com.|School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, China. chsensen@163.com.
authors.forename: Sensen
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Department of Oncology, General Hospital of Jinan Iron and Steel Group Limited Company, Jinan, China. lijianzhong10@126.com.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology, Affiliated Hospital of Taishan Medical College, Taian, China. taianliuwenjian@sina.com.
authors.forename: Wenjian
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Oncology, General Hospital of Jinan Iron and Steel Group Limited Company, Jinan, China. aaa8654@163.com.
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Oncology, Zhangqiu People's Hospital of Shandong Province, Jinan, China. sdzqjh@163.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. liuj691012@126.com.
authors.forename: Xiuchun
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. lj691012@126.com.
authors.forename: Liangjun
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. mayuan12134@126.com.|School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, China. mayuan12134@126.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Basic Laboratory, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. songbaojn@126.com.
authors.forename: Bao
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, 440 Jiyan Road, Jinan, 250117, China. liujie691012@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000453:epidemiology / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D016207:Cytokines; D008233:Lymphotoxin-alpha