title: Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
abstract: MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular.
authors.forename: Christiane Maria
authors.initials: CM
authors.lastname: Ayo
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular.
authors.forename: Amanda Priscila de
authors.initials: AP
authors.lastname: Oliveira
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular.
authors.forename: Ana Vitória da Silveira
authors.initials: AV
authors.lastname: Camargo
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular.
authors.forename: Cinara Cássia Brandão de
authors.initials: CC
authors.lastname: Mattos
authors.affiliation: Departamento de Cardiologia e Cirurgia Cardiovascular, Faculdade de Medicina de São José do Rio Preto, São Paulo, Brazil.
authors.forename: Reinaldo Bulgarelli
authors.initials: RB
authors.lastname: Bestetti
authors.affiliation: Laboratório de Imunogenética, Departamento de Biologia Molecular.
authors.forename: Luiz Carlos de
authors.initials: LC
authors.lastname: Mattos
mesh_terms: D000328:Adult; D000483:Alleles; D002598:Chagas Cardiomyopathy / Q000235:genetics* / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D005805:Genes, MHC Class I; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008297:Male; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D055655:NK Cell Lectin-Like Receptor Subfamily K
keywords: Chagas disease; MICA polymorphism; chronic Chagas heart disease; left ventricular systolic dysfunction