title: Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012).
abstract: CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).
authors.affiliation: Veterinary Medical Teaching Hospital, University of California-Davis, Davis, CA, USA.|Oncology Service, Upstate Veterinary Specialists, Greenville, SC, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Collette
authors.affiliation: Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.|Oncology Service, Blue Pearl Veterinary Partners, Louisville, KY, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Allstadt
authors.affiliation: Department of Medical Sciences, Univeristy of Wisconsin-Madison, Madison, WI, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Chon
authors.affiliation: Department of Pathology, Microbiology and Immunology, University of California-Davis, CA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Vernau
authors.affiliation: Department of Clinical Sciences, Auburn University, Auburn, AL, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Smith
authors.affiliation: Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Garrett
authors.affiliation: Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA, USA.|Oncology Service, Seattle Veterinary Specialists, Seattle, WA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Choy
authors.affiliation: Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Rebhun
authors.affiliation: Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.
authors.forename: C O
authors.initials: CO
authors.lastname: Rodriguez
authors.affiliation: Department of Surgical and Radiological Sciences, University of California-Davis, Davis, CA, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Skorupski
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D053208:Kaplan-Meier Estimate; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008499:Medical Records; D011241:Prednisone / Q000494:pharmacology; D011379:Prognosis; D012582:Schools, Veterinary; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States; D014748:Vinca Alkaloids / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014748:Vinca Alkaloids; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: CHOP; cat; feline; lymphoma; maintenance-free chemotherapy; survival