title: Degree centrality and fractional amplitude of low-frequency oscillations associated with Stroop interference.
abstract: Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating functions of the frontal lobes and other associated structures. Here we investigated the correlation between resting-state functional magnetic imaging (fMRI) measures [degree centrality (DC)/fractional amplitude of low frequency fluctuations (fALFFs)] and Stroop interference. We examined this relationship in the brains of 958 healthy young adults. DC reflects the number of instantaneous functional connections between a region and the rest of the brain within the entire connectivity matrix of the brain (connectome), and thus how much of the node influences the entire brain areas, while fALFF is an indicator of the intensity of regional brain spontaneous activity. Reduced Stroop interference was associated with larger DC in the left lateral prefrontal cortex, left IFJ, and left inferior parietal lobule as well as larger fALFF in the areas of the dorsal attention network and the precuneus. These findings suggest that Stroop performance is reflected in resting state functional properties of these areas and the network. In addition, default brain activity of the dorsal attention network and precuneus as well as higher cognitive processes represented there, and default stronger global influence of the areas critical in executive functioning underlie better Stroop performance.
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. Electronic address: takehi@idac.tohoku.ac.jp.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Taki
authors.affiliation: Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Nouchi
authors.affiliation: Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sekiguchi
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashizume
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sassa
authors.affiliation: Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kotozaki
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Carlos Makoto
authors.initials: CM
authors.lastname: Miyauchi
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Yokoyama
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Iizuka
authors.affiliation: Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Seishu
authors.initials: S
authors.lastname: Nakagawa
authors.affiliation: Faculty of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Nagase
authors.affiliation: Faculty of Medicine, Tohoku University, Sendai, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kunitoki
authors.affiliation: Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Department of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kawashima
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D057190:Stroop Test; D055815:Young Adult
keywords: Amplitude of low-frequency fluctuations; Degree centrality; Dorsolateral prefrontal cortex; Inferior frontal junction; Resting state; Stroop interference