title: [The effect of vasonit on the structural/functional state of erythrocyte cytoplasmic membrane in patients with ischemic stroke].
abstract: OBJECTIVE
  To study the effect of vasonit on the structural/functional state of erythrocyte cytoplasmic membrane in patients with ischemic stroke (11) using atomic-power microscopy in vitro.
  
  
  METHODS
  We examined 45 patients with II. Patients of the main group (n=30) received vasonit and standard treatment, 15 patients of the comparison group received only standard treatment. To assess the severity of patient's condition, we used the NIH stroke scale, modified Rankin scale, the Barthel index and the Rivermead Mobility index. Dried erythrocyte preparations were made to study erythrocyte cytoplasmic membrane. Scanning was performed using an atomic-power microscope manufactured by "SOLVER P47-Pro" (NT-MDT, Russia).
  
  
  CONCLUSIONS
  A statistically significant positive dynamics of neurological deficit and patient's functional state was found in the 14" day of the study. A significant decrease in Young's modulus value was identified in the main group that suggested the increase in the elasticity of erythrocyte cytoplasmic membrane.
authors.affiliation: Ulyanovsk State University, Ulyanovsk.
authors.forename: L A
authors.initials: LA
authors.lastname: Belova
authors.affiliation: Ulyanovsk State University, Ulyanovsk.
authors.forename: V V
authors.initials: VV
authors.lastname: Mashin
authors.affiliation: Ulyanovsk State University, Ulyanovsk.
authors.forename: A N
authors.initials: AN
authors.lastname: Proshin
authors.affiliation: Ulyanovsk State University, Ulyanovsk.
authors.forename: B B
authors.initials: BB
authors.lastname: Kostishko
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications; D055119:Elastic Modulus / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D018625:Microscopy, Atomic Force; D008875:Middle Aged; D009278:Naphazoline / Q000627:therapeutic use*; D012720:Severity of Illness Index; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
chemical_list: D000316:Adrenergic alpha-Agonists; D009278:Naphazoline