title: Decreased SAPK/JNK signalling affects cytokine release and STAT3 activation in psoriatic fibroblasts.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain.|Center of Molecular Recognition and Technological Development (IDM), Valencia, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Arasa
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain.|Center of Molecular Recognition and Technological Development (IDM), Valencia, Spain.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Terencio
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain.|Center of Molecular Recognition and Technological Development (IDM), Valencia, Spain.
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Andrés
authors.affiliation: Department of Dermatology, University Hospital La Plana, Vila-real, Spain.|Department of Medicine and Surgery, CEU Cardenal Herrera University, Castellón de la Plana, Spain.
authors.forename: Francisca
authors.initials: F
authors.lastname: Valcuende-Cavero
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Valencia, Spain.|Center of Molecular Recognition and Technological Development (IDM), Valencia, Spain.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Montesinos
mesh_terms: D016022:Case-Control Studies; D005347:Fibroblasts; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism* / Q000494:pharmacology; D016209:Interleukin-8 / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism; D010766:Phosphorylation; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; D048031:JNK Mitogen-Activated Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048051:p38 Mitogen-Activated Protein Kinases
keywords: MAPkinases; STAT3; TNF-alpha; fibroblasts; psoriasis