title: Characteristic location and growth patterns of functioning pituitary adenomas: correlation with histological distribution of hormone-secreting cells in the pituitary gland.
abstract: OBJECTIVE
  To evaluate the correlation between the magnetic resonance imaging findings of functional pituitary adenomas and histological distribution of hormone-secreting cells in pituitary gland.
  
  
  METHODS
  Forty-nine patients with pathologically confirmed functional micro and macro pituitary adenomas were retrospectively reviewed for its location and growth direction.
  
  
  RESULTS
  Micro-prolactin, micro-adrenocorticotropic hormone (ACTH), and micro-growth hormone (GH) producing adenomas showed specific location (P-value <.01). Macro-GH and macro-thyroid-stimulating hormone producing adenomas showed specific growth direction (P-value <.05), whereas macro-prolactin and macro-ACTH producing adenomas did not.
  
  
  CONCLUSIONS
  The functional pituitary microadenomas' location and macroadenomas' growth pattern correlate well with histological distribution of hormone-secreting cells in pituitary gland.
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Jun Seung
authors.initials: JS
authors.lastname: Baik
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Mi Hyun
authors.initials: MH
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea. Electronic address: ahn-kj@catholic.ac.kr.
authors.forename: Kook-Jin
authors.initials: KJ
authors.lastname: Ahn
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: So Lyung
authors.initials: SL
authors.lastname: Jung
authors.affiliation: Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Bum-Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Sin Soo
authors.initials: SS
authors.lastname: Jeun
authors.affiliation: Department of Neurosurgery, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Yong-Kil
authors.initials: YK
authors.lastname: Hong
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism* / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology*; D011388:Prolactin / Q000378:metabolism; D012189:Retrospective Studies; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone
keywords: Functional pituitary adenoma; Histological distribution; Location; MRI