title: Physiological Consequences of Compartmentalized Acyl-CoA Metabolism.
abstract: Meeting the complex physiological demands of mammalian life requires strict control of the metabolism of long-chain fatty acyl-CoAs because of the multiplicity of their cellular functions. Acyl-CoAs are substrates for energy production; stored within lipid droplets as triacylglycerol, cholesterol esters, and retinol esters; esterified to form membrane phospholipids; or used to activate transcriptional and signaling pathways. Indirect evidence suggests that acyl-CoAs do not wander freely within cells, but instead, are channeled into specific pathways. In this review, we will discuss the evidence for acyl-CoA compartmentalization, highlight the key modes of acyl-CoA regulation, and diagram potential mechanisms for controlling acyl-CoA partitioning.
authors.affiliation: From the Departments of Nutrition and.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Cooper
authors.affiliation: From the Departments of Nutrition and.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Young
authors.affiliation: From the Departments of Nutrition and Medicine, University of North Carolina, Chapel Hill, North Carolina 27599.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Klett
authors.affiliation: From the Departments of Nutrition and rcoleman@unc.edu.
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Coleman
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D000215:Acylation; D000818:Animals; D002451:Cell Compartmentation; D003470:Culture Media; D006706:Homeostasis; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction; D013379:Substrate Specificity; D022722:Thermogenesis
chemical_list: D000214:Acyl Coenzyme A; D003470:Culture Media
keywords: acyl-CoA; acyltransferase; fatty acid metabolism; fatty acid oxidation; phospholipid; thermogenesis; thioesterase; triacylglycerol