title: Reduced circulating miR-196b levels is associated with preeclampsia.
abstract: MicroRNAs (miRs) are small noncoding RNAs, highly stable in plasma, that regulate gene expression by base-pairing to the 3'-untranslated region of target mRNAs. We compared the expression of 3 circulating miRs (miR-125b, miR-146a, and miR-196b), which is related to the control of cell proliferation, differentiation, and apoptosis in preeclamptic (n=19) and healthy pregnant women (n=14). We found that women with preeclampsia (PE) presented lower expression of miR-196b (-2.9-fold change). The other miRs were at similar levels. This study is the first to demonstrate this difference, and highlights new opportunities for investigation into the role of miRs in PE.
authors.affiliation: Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, MG, Brazil.
authors.forename: C B
authors.initials: CB
authors.lastname: Campos
authors.affiliation: Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, SGAN 916, Asa Norte, Brasília, DF 70790-160, Brazil.
authors.forename: T M
authors.initials: TM
authors.lastname: Marques
authors.affiliation: Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, SGAN 916, Asa Norte, Brasília, DF 70790-160, Brazil.
authors.forename: R W
authors.initials: RW
authors.lastname: Pereira
authors.affiliation: Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, MG, Brazil. Electronic address: valeria.sandrim@ibb.unesp.br.
authors.forename: V C
authors.initials: VC
authors.lastname: Sandrim
keywords: Circulating microRNA; Preeclampsia; miR-196b