title: [Heparin for clearance of peripherally inserted central venous catheter in newborns: an in vitro study].
abstract: OBJECTIVE
  To compare the efficacy of two concentrations of heparin to clear the lumen of in vitro clotted neonatal peripherally inserted central catheters (PICCs).
  
  
  METHODS
  This is an in vitro, experimental quantitative study of 76 neonatal 2.0Fr PICCs coagulated in vitro. The catheters were divided into two groups of 38 PICCs each. In both groups an infusion of low molecular weight heparin was administered with a dose of 25IU/mL for Group 1 and 50IU/mL for Group 2. The negative pressure technique was applied to the catheters of both groups at 5, 15 and 30minutes and at 4hours to test their permeability. Kaplan-Meier survival analysis was used to verify the outcome of the groups according to time intervals.
  
  
  RESULTS
  The comparison between both groups in the first five minutes showed that more catheters from Group 2 were cleared compared to Group 1 (57.9 vs. 21.1%, respectively). Kaplan-Meier survival analysis showed that less time was needed to clear catheters treated with 50IU/mL of heparin (p<0.001).
  
  
  CONCLUSIONS
  The use of low-molecular weight heparin at a concentration of 50IU/mL was more effective in restoring the permeability of neonatal PICCs occluded in vitro by a clot, and the use of this concentration is within the safety margin indicated by scientific literature.
authors.affiliation: Universidade Estadual de Londrina (UEL), Londrina, PR, Brasil.
authors.forename: Talita
authors.initials: T
authors.lastname: Balaminut
authors.affiliation: Universidade Estadual de Londrina (UEL), Londrina, PR, Brasil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Venturini
authors.affiliation: Hospital Universitário de Londrina (HUL), Londrina, PR, Brasil.
authors.forename: Valéria Costa Evangelista
authors.initials: VC
authors.lastname: da Silva
authors.affiliation: Universidade Estadual de Londrina (UEL), Londrina, PR, Brasil.
authors.forename: Edilaine Giovanini
authors.initials: EG
authors.lastname: Rossetto
authors.affiliation: Universidade Estadual de Londrina (UEL), Londrina, PR, Brasil. Electronic address: adrianazani@hotmail.com.
authors.forename: Adriana Valongo
authors.initials: AV
authors.lastname: Zani
mesh_terms: D061807:Catheter Obstruction; D002405:Catheterization, Central Venous / Q000379:methods; D002406:Catheterization, Peripheral; D062905:Central Venous Catheters; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn
chemical_list: D006493:Heparin
keywords: Cateterismo venoso central; Catheter obstruction; Central venous catheterization; Heparin; Heparina; Newborn; Obstrução do cateter; Recém‐nascido