title: Limited value of angiogenic factors in obese women.
abstract: We performed a case-control study assessing the predictive value of sVEGFR and PlGF for preeclampsia in a population with high obesity prevalence. Body mass index and circulating mean concentrations of sVEGFR and PlGF were significantly higher in preeclamptic women. However, a two variable model associating sVEGFR and PlGF dosages was not better than the model including only age and BMI. When the prevalence of obesity is high, the extra benefit of the dosages of angiogenic factors appears to be of limited value.
authors.affiliation: AP-HP, Paris 13 University, Department of Obstetrics and Gynecology, Hôpital Jean Verdier, France.
authors.forename: Priscille
authors.initials: P
authors.lastname: Loire
authors.affiliation: AP-HP, Paris 7 University, Clinical Research Unit, Hôpital Fernand Widal, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Vicaut
authors.affiliation: AP-HP, Department of Biology, Hôpital Jean Verdier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Cruaud
authors.affiliation: AP-HP, Paris 13 University, Department of Biochemistry, Hôpital Jean Verdier, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Charnaux
authors.affiliation: AP-HP, Paris 13 University, Department of Obstetrics and Gynecology, Hôpital Jean Verdier, France. Electronic address: lionel.carbillon@jvr.aphp.fr.
authors.forename: Lionel
authors.initials: L
authors.lastname: Carbillon
keywords: BMI; Obesity; Overweight; PlGF; Preeclampsia; SFlt-1; sVEGFR