title: Misoprostol versus prostaglandin E2 gel for labor induction in premature rupture of membranes after 34 weeks of pregnancy.
abstract: BACKGROUND
  Both misoprostol and prostaglandin E2 (PGE2) gel are used for labor induction in women with premature rupture of membranes (PROM).
  
  
  OBJECTIVE
  To evaluate studies comparing the effects of misoprostol and PGE2 gel in labor induction.
  
  
  METHODS
  Databases including Medline, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant papers.
  
  
  METHODS
  Randomized controlled trials comparing the use of misoprostol and PGE2 gel for labor induction in women with PROM were included.
  
  
  METHODS
  For meta-analyses, the Mantel-Haenszel method was used for dichotomous data, and the inverse variance method was used for continuous data.
  
  
  RESULTS
  Four randomized controlled studies (n=615) were included. There were no significant differences between the two groups in the induction-to-delivery interval (mean difference -4.44 hours; 95% confidence interval [CI] -9.35 to 0.48), rate of cesarean delivery (odds ratio [OR] 0.90; 95% CI 0.44-1.85), and rate of neonatal intensive care unit admission (OR 0.89; 95% CI 0.57-1.38). Women receiving misoprostol had a significantly higher rate of tachysystole than did those receiving PGE2 gel (OR 4.84; 95% CI 2.46-9.54).
  
  
  CONCLUSIONS
  Misoprostol is as efficacious and safe as PGE2 gel for labor induction in women with PROM.
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Xie
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China.
authors.forename: Meiqun
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Bao'an Maternal and Child Health Hospital, Shenzhen, Guangdong Province, China. Electronic address: lirongren2014@163.com.
authors.forename: Lirong
authors.initials: L
authors.lastname: Ren
mesh_terms: D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods; D016595:Misoprostol / Q000008:administration & dosage*; D010120:Oxytocics / Q000008:administration & dosage*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic
chemical_list: D005782:Gels; D010120:Oxytocics; D016595:Misoprostol; D015232:Dinoprostone
keywords: Cervical ripening; Labor induction; Misoprostol; Premature rupture of membranes; Prostaglandin E2 gel