title: The relationship between Activin A and anti-angiogenic factors in the development of pre-eclampsia.
abstract: Anti-angiogenic factors such as sFlt/sEng contribute to the pathology seen in preeclampsia. Activin A, which is released by the placenta following exposure to oxidative stress and elevated in preeclampsia, may interact with sFlt/sEng during the disease process. Using placental explant cultures, we determined that transcription of sFLT1, ENG and INHBA was upregulated following exposure to oxidative stress or IL-6. Explants treated with Activin A did not increase transcription of sFLT1, ENG. Conversely, treatment of placental explants with sFlt/sEng did not increase transcription of INHBA. These data may suggest that Activin A and sFlt/sEng contribute to preeclampsia via separate pathways.
authors.affiliation: The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.
authors.forename: Seshini
authors.initials: S
authors.lastname: Gurusinghe
authors.affiliation: The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia; Department of Obstetrics and Gynecology, Monash University, Australia.
authors.forename: Euan M
authors.initials: EM
authors.lastname: Wallace
authors.affiliation: The Ritchie Centre, Monash Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia; Department of Obstetrics and Gynecology, Monash University, Australia. Electronic address: rebecca.lim@monash.edu.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Lim
keywords: Inflammation; Oxidative stress; Preeclampsia; Pregnancy