title: Lack of association between leptin, leptin receptor, adiponectin gene polymorphisms and epicardial adipose tissue, abdominal visceral fat volume and atherosclerotic burden in psoriasis patients.
abstract: BACKGROUND
  Identifying psoriasis patients who present a higher risk of developing cardiovascular co-morbidities is of upmost importance. Two key adipokines, leptin and adiponectin, may play a role connecting psoriasis and its major co-morbidities.
  
  
  OBJECTIVE
  To evaluate the potential contribution of LEPrs2167270(19 G/A), LEPRrs1137100(326 A/G) and ADIPOQrs1501299(276 G/T) gene polymorphisms in psoriasis susceptibility and their influence in epicardial adipose tissue and abdominal visceral fat volume and subclinical atherosclerosis in severe psoriasis patients.
  
  
  METHODS
  One hundred severe psoriasis patients underwent clinical and laboratory evaluation, DNA genotyping and multi-detector computed tomography scan for epicardial adipose tissue, abdominal visceral fat and coronary artery calcification assessment. DNA control group was obtained from a previously anonymized biobank of 206 adult subjects without psoriasis.
  
  
  RESULTS
  No association was observed between the studied gene polymorphisms and psoriasis susceptibility, CAC or increased EAT or AVF volume.
  
  
  CONCLUSIONS
  The studied polymorphisms do not seem, at least in this cohort of patients, to be a genetic risk factor for the development of atherosclerosis or increased adiposity in psoriasis.
authors.affiliation: Department of Dermatology, Centro Hospitalar do Porto , Porto , Portugal .
authors.forename: Tiago
authors.initials: T
authors.lastname: Torres
authors.forename: Nuno
authors.initials: N
authors.lastname: Bettencourt
authors.forename: Joana
authors.initials: J
authors.lastname: Ferreira
authors.forename: Cláudia
authors.initials: C
authors.lastname: Carvalho
authors.forename: Denisa
authors.initials: D
authors.lastname: Mendonça
authors.forename: Carlos
authors.initials: C
authors.lastname: Vasconcelos
authors.forename: Manuela
authors.initials: M
authors.lastname: Selores
authors.forename: Berta
authors.initials: B
authors.lastname: Silva
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D002114:Calcinosis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D015331:Cohort Studies; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D005838:Genotype; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D020738:Leptin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics / Q000473:pathology*; D010496:Pericardium / Q000378:metabolism / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D054411:Receptors, Leptin / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin
keywords: Adiponectin; Leptin; atherosclerosis; cardiovascular disease; epicardial adipose tissue; gene polymorphism; leptin receptor; psoriasis