title: Association between rs9904341 G<C gene polymorphism and susceptibility to pancreatic cancer in a Chinese population.
abstract: We conducted a case-control study to investigate the association between the survivin rs9904341 G<C polymorphism and risk of pancreatic cancer. A total of 261 pancreatic cancer patients who were pathologically confirmed to have pancreatic cancer were included in the study. Polymorphisms of rs9904341 G<C were assessed by polymerase chain reaction-restriction fragment length polymorphism. Pancreatic cancer patients were more likely to be smokers, have a family history of cancer, and have diabetes. Using multivariate logistic regression analysis, the CC genotype was found to be associated with a significantly increased risk of pancreatic cancer risk compared with the GG genotype (odds ratio = 1.85, 95% confidence interval = 1.12-3.01). Moreover, those carrying the C allele had a higher risk of pancreatic cancer compared to those with the G allele (odds ratio = 1.38, 95% confidence interval = 1.08-1.77). In conclusion, we found that the survivin rs9904341 polymorphism was associated with an increased risk of acute pancreatitis.
authors.affiliation: Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
authors.forename: L
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China qinlu1981@163.com.
authors.forename: T
authors.initials: T
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin