title: Left Ventricle-Arterial System Interaction in Heart Failure.
abstract: Ejection fraction (EF) has been viewed as an important index in assessing the contractile state of the left ventricle (LV). However, it is frequently inadequate for the diagnosis and management of heart failure (HF), as a significant subset of HF patients have been found to have reduced EF (HFrEF) whereas others have preserved EF (HFpEF). It should be noted that the function of the LV is dependent on both preload and afterload, as well as its intrinsic contractile state. Furthermore, stroke volume (SV) is dependent on the properties of the arterial system (AS). Thus, the LV-arterial system interaction plays an important role in those patients with HF. This aspect is investigated through the analysis of the specific parameters involved in the coupling of the LV and AS. This includes contractility and the systolic/diastolic indices of the LV. Furthermore, AS afterload parameters such as vascular stiffness and arterial compliance, and their derived coupling coefficient, are also investigated. We conclude that those parameters, which relate to LV structural changes, are most appropriate in quantifying the LV-AS interaction.
authors.affiliation: Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA. ; College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.
authors.forename: John K-J
authors.initials: JK
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Rutgers New Jersey Medical School, Newark, NJ, USA. ; Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA.
authors.forename: Glen
authors.initials: G
authors.lastname: Atlas
keywords: arterial compliance; cardiac contractility; coupling coefficient; elastance; muscle shortening; vascular stiffness