title: Leukocyte chemotactic factor 2 (LECT2) amyloidosis presenting as pulmonary-renal syndrome: a case report and review of the literature.
abstract: Leukocyte chemotactic factor-2 (LECT2) amyloidosis has been described as being associated with kidney disease; however, no clinical manifestations outside of the kidney have been previously reported. We describe a patient presenting with pulmonary-renal syndrome found to have deposition of amyloidogenic LECT2 (ALECT2) within both the lung and the kidney. This case is unique in regard to both the patient's clinical presentation of pulmonary-renal syndrome in the setting of amyloidosis and the biopsy finding of ALECT2 deposition within the lung. It also emphasizes the importance of tissue diagnosis in such cases, given that amyloidosis was not initially considered in the differential diagnosis.
authors.affiliation: Department of Pathology , University of Chicago , Chicago, IL , USA.
authors.forename: Mazdak A
authors.initials: MA
authors.lastname: Khalighi
authors.affiliation: Department of Internal Medicine , University of California , San Francisco, Fresno, CA , USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Yue
authors.affiliation: Department of Nephrology , University of California , San Francisco, Fresno, CA , USA.
authors.forename: Mei-Tsuey
authors.initials: MT
authors.lastname: Hwang
authors.affiliation: Department of Pathology and Laboratory Medicine , University of California , Los Angeles, CA , USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Wallace
keywords: amyloid; lect2; pulmonary-renal syndrome