title: Assessment of the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus).
abstract: The present study aimed to assess the cytotoxic, genotoxic, and antigenotoxic activities of sucupira oil (Pterodon emarginatus), which is commonly used as an anti-rheumatic, analgesic, antimicrobial, anticercariae, and anti-inflammatory. We used the mouse bone marrow micronucleus test as an experimental model. The experimental groups, which consisted of 5 animals, was administered sucupira oil (100 mg/kg body weight) intraperitoneally and evaluated 24 h after the treatment. The negative control group was treated with sterile distilled water, and the positive control group received an intraperitoneal dose of 4 mg/kg mitomycin C, a dose that corresponds to 80% of its median lethal dose. Cytotoxicity was determined by the polychromatic to normochromatic erythrocytes ratio (PCE/NCE). Sucupira oil had no significant effects (P > 0.05) on the frequency of micronucleated polychromatic erythrocytes as compared to the negative control group. However, the difference was significant (P < 0.005) as compared to the positive control group. The PCE/NCE (100 mg/kg oil and 4 mg/kg mitomycin) ratio did not differ between the experimental group and the positive control group, but it differed significantly when compared to the negative control group (P < 0.05). Thus, these findings suggested that the P. emarginatus oil showed no cytotoxic, mutagenic, or antimutagenic activities at a dose of 100 mg/kg.
authors.affiliation: Laboratório de Estudos Experimentais e Biotecnologia, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: L A
authors.initials: LA
authors.lastname: Assunção
authors.affiliation: Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: S R
authors.initials: SR
authors.lastname: Lemes
authors.affiliation: Laboratório de Estudos Experimentais e Biotecnologia, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: L A
authors.initials: LA
authors.lastname: Araújo
authors.affiliation: Biomedicina, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: C R
authors.initials: CR
authors.lastname: Costa
authors.affiliation: Biomedicina, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: L G
authors.initials: LG
authors.lastname: Magalhães
authors.affiliation: Laboratório de Estudos Experimentais e Biotecnologia, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: K K
authors.initials: KK
authors.lastname: Moura
authors.affiliation: Laboratório de Estudos Experimentais e Biotecnologia, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil melo.reis@ig.com.br.
authors.forename: P R
authors.initials: PR
authors.lastname: Melo-Reis
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001854:Bone Marrow Cells / Q000187:drug effects*; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D010938:Plant Oils