title: Oxybutynin as a treatment for generalized hyperhidrosis: a randomized, placebo-controlled trial.
abstract: BACKGROUND
  Hyperhidrosis is a disorder that can impair quality of life. Localized treatments may be cumbersome and ineffective, and no systemic treatments have proven to be significantly beneficial.
  
  
  OBJECTIVE
  To evaluate the effectiveness and tolerance of low-dose oxybutynin for hyperhidrosis.
  
  
  METHODS
  We conducted a prospective, randomized, placebo-controlled trial. From June 2013 to January 2014, 62 patients with localized or generalized hyperhidrosis were enrolled. Oxybutynin was started at a dose of 2·5 mg per day and increased gradually to 7·5 mg per day. The primary outcome was defined as improvement of at least one point on the Hyperhidrosis Disease Severity Scale (HDSS). Dermatology Life Quality Index (DLQI) and tolerance were also reported.
  
  
  RESULTS
  Most patients (83%) in our study had generalized hyperhidrosis. Oxybutynin was superior to placebo in improving the HDSS: 60% of patients treated with oxybutynin, compared with 27% of patients treated with placebo, improved at least one point on the HDSS (P = 0·009). The mean improvement in quality of life measured by DLQI was significantly better in the oxybutynin arm (6·9) than in the placebo arm (2·3). The most frequent side-effect was dry mouth, which was observed in 43% of the patients in the oxybutynin arm, compared with 11% in the placebo arm.
  
  
  CONCLUSIONS
  Treatment with low-dose oxybutynin is effective in reducing symptoms of hyperhidrosis in generalized or localized forms. Side-effects were frequent but minor and mainly involved dry mouth.
authors.affiliation: Dermatologist, Brest, France.|Department of Dermatology, University Hospital, Brest, France.
authors.forename: M
authors.initials: M
authors.lastname: Schollhammer
authors.affiliation: Department of Dermatology, University Hospital, Brest, France.
authors.forename: E
authors.initials: E
authors.lastname: Brenaut
authors.affiliation: Dermatologist, Quimper, France.
authors.forename: N
authors.initials: N
authors.lastname: Menard-Andivot
authors.affiliation: Dermatologist, Brest, France.|Department of Dermatology, University Hospital, Brest, France.
authors.forename: M
authors.initials: M
authors.lastname: Pillette-Delarue
authors.affiliation: Dermatologist, Landerneau, France.
authors.forename: A
authors.initials: A
authors.lastname: Zagnoli
authors.affiliation: Dermatologist, Brest, France.
authors.forename: M
authors.initials: M
authors.lastname: Chassain-Le Lay
authors.affiliation: Department of Internal Medicine, University Hospital, Brest, France.
authors.forename: B
authors.initials: B
authors.lastname: Sassolas
authors.affiliation: Dermatologist, Brest, France.|Department of Dermatology, University Hospital, Brest, France.
authors.forename: N
authors.initials: N
authors.lastname: Jouan
authors.affiliation: Dermatologist, Brest, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Le Ru
authors.affiliation: Department of Dermatology, University Hospital, Brest, France.
authors.forename: C
authors.initials: C
authors.lastname: Abasq-Thomas
authors.affiliation: Dermatologist, Brest, France.|Department of Dermatology, University Hospital, Brest, France.
authors.forename: M
authors.initials: M
authors.lastname: Greco
authors.affiliation: Dermatologist, Brest, France.
authors.forename: K
authors.initials: K
authors.lastname: Penven
authors.affiliation: Department of Dermatology, University Hospital, Brest, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Roguedas-Contios
authors.affiliation: Dermatologist, Landerneau, France.
authors.forename: D
authors.initials: D
authors.lastname: Dupré-Goetghebeur
authors.affiliation: Dermatologist, Landerneau, France.
authors.forename: C
authors.initials: C
authors.lastname: Gouedard
authors.affiliation: Department of Dermatology, University Hospital, Brest, France.
authors.forename: L
authors.initials: L
authors.lastname: Misery
authors.affiliation: INSERM CIC 1412, Université de Brest, Brest, France.
authors.forename: G
authors.initials: G
authors.lastname: Le Gal
mesh_terms: D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D017060:Patient Satisfaction; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D014987:Xerostomia / Q000139:chemically induced; D055815:Young Adult
chemical_list: D008333:Mandelic Acids; D018727:Muscarinic Antagonists; C005419:oxybutynin