title: [The ESCRT complex: from endosomal transport to the development of multicellular organisms].
abstract: Since its discovery more than 50 years ago, the endo-lysosomal system has emerged as a central integrator of different cellular activities. This vesicular trafficking apparatus governs processes as diverse as the transduction of stimuli by growth factor receptors, the recycling and secretion of signaling molecules and the regulation of cellular homeostasis through autophagy. Accordingly, dysfunctions of the vesicular transport machinery have been linked to a growing number of pathologies. In this review we take the "Endosomal Sorting Complex Required for Transport" (ESCRT) as an example to illustrate the multiple functions of an evolutionarily conserved endosomal transport machinery. We describe the major concepts that have emerged from the study of this machinery at the level of the development and the physiology of multi-cellular organisms. In particular, we highlight the essential contributions of ESCRT proteins on the regulation of three biological processes: the endocytic regulation of cell signaling, autophagy and its role in neuronal morphogenesis and finally the biogenesis and function of extracellular vesicles.
authors.forename: Thomas
authors.initials: T
authors.lastname: Juan
authors.forename: Maximilian
authors.initials: M
authors.lastname: Fürthauer
mesh_terms: D000818:Animals; D001343:Autophagy; D001692:Biological Transport; D056827:Endosomal Sorting Complexes Required for Transport / Q000737:chemistry / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism; D006706:Homeostasis; D055495:Neurogenesis; D017978:Receptors, Growth Factor / Q000502:physiology; D051880:Receptors, Notch / Q000502:physiology; D015398:Signal Transduction; D022161:Transport Vesicles / Q000502:physiology*; D051153:Wnt Proteins / Q000502:physiology
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D053823:Hedgehog Proteins; D017978:Receptors, Growth Factor; D051880:Receptors, Notch; D051153:Wnt Proteins