title: Primary Epithelioid Angiosarcoma of Bone with Robust Cell Cycle Progression and High Expression of SPARC: A Case Report and Review of the Literature.
abstract: Epithelioid angiosarcoma of bone is a rare entity. Secreted protein acidic and rich in cysteine (SPARC), or osteonectin, is a secreted glycoprotein that has been implicated in tumorigenesis. We report a case of epithelioid angiosarcoma involving the long bones of the lower extremity showing diffuse and strong expression for SPARC immunohistochemistry in tumor cells. Ki-67 was positive in ~50% of tumor cell nuclei and the accompanying mitotic index was 19 mitotic figures/10 high power fields.Expression of SPARC in tumors has been correlated with sensitivity to nanoparticle albumin-bound paclitaxel (Nab-paclitaxel), particularly in the context of robust cell cycle progression into the mitotic phase. This finding could suggest new therapeutic options for further consideration.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science center at Houston, TX, USA.
authors.forename: Shakuntala H
authors.initials: SH
authors.lastname: Mauzo
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science center at Houston, TX, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science center at Houston, TX, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Brown
authors.affiliation: Department of Radiology, University of Texas Health Science center at Houston, TX, USA.
authors.forename: HaiThuy N
authors.initials: HN
authors.lastname: Nguyen
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas Health Science center at Houston, TX, USA Peisha.Yan@uth.tmc.edu.
authors.forename: Peisha
authors.initials: P
authors.lastname: Yan
mesh_terms: D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000473:pathology*; D002453:Cell Cycle; D002454:Cell Differentiation; D015622:Epithelioid Cells / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015676:Osteonectin / Q000378:metabolism*
chemical_list: D015676:Osteonectin
keywords: Nab-paclitaxel; SPARC; bone; epithelioid angiosarcoma