title: [Inflammatory mechanisms of fatigue syndrome in Parkinson's disease].
abstract: OBJECTIVE
  To study clinical characteristics of fatigue syndrome in patients with Parkinson's disease (PD) and a role of inflammation in its development.
  
  
  METHODS
  We examined 98 patients with confirmed diagnosis of PD and 18 healthy people. Clinical examination included an analysis of anamnesis and objective somatic symptoms. The unified Parkinson's disease rating scale, The Hoehn and Yahr scale, the Multidimensional Fatigue Inventory (MFI-20) scale, the Modified Fatigue Impact Scale (MFIS), the Hospital Anxiety and Depression Scale (HADS), The Epworth Sleepiness Scale (ESS), Vein's Autonomic Symptoms Questionnaire (VASQ) were used for quantitative assessment. Serum concentrations of IL-6 were measured in 65 patients and 18 controls using ELISA.
  
  
  CONCLUSIONS
  In PD patients, fatigue assessed with MFI-20 was recorded in 46 (47%) cases and fatigue as assessed with MFIS in 45 (46%) of cases. High frequency and severity of fatigue syndrome were observed. The most prominent components in the structure of fatigue were physical fatigue, reduced motivation and decreased activity. Signs of fatigue increased with disease progression. Correlation between fatigue and axial motor symptoms of PD is of interest. Patients had higher serum IL-6 levels compared to the controls. Concentrations of IL-6 were correlated with fatigue severity and its main components (general and physical fatigue, decreased activity) and with depression level.
authors.affiliation: Wagner Perm State Medicine Academy, Perm.
authors.forename: T V
authors.initials: TV
authors.lastname: Baidina
authors.affiliation: Wagner Perm State Medicine Academy, Perm.
authors.forename: T I
authors.initials: TI
authors.lastname: Torgan
authors.affiliation: Wagner Perm State Medicine Academy, Perm.
authors.forename: N D
authors.initials: ND
authors.lastname: Demchuk
authors.affiliation: Wagner Perm State Medicine Academy, Perm.
authors.forename: M A
authors.initials: MA
authors.lastname: Danilova
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D005222:Mental Fatigue / Q000097:blood / Q000209:etiology* / Q000523:psychology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000150:complications* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales
chemical_list: D015850:Interleukin-6