title: Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67.
abstract: OBJECTIVE
  To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury.
  
  
  METHODS
  Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry.
  
  
  RESULTS
  Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue.
  
  
  CONCLUSIONS
  Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Ana Paula Bomfim Soares
authors.initials: AP
authors.lastname: Campelo
authors.affiliation: Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Márcio Wilker Soares
authors.initials: MW
authors.lastname: Campelo
authors.affiliation: Department of Morphology, UFC, Fortaleza, CE, Brazil.
authors.forename: Gerly Anne de Castro
authors.initials: GA
authors.lastname: Brito
authors.affiliation: Department of Pharmacology, UFC, Fortaleza, CE, Brazil.
authors.forename: Francisco Vagnaldo Fechine
authors.initials: FV
authors.lastname: Jamacaru
authors.affiliation: Department of Morphology, UFC, Fortaleza, CE, Brazil.
authors.forename: Renata Ferreira de Carvalho
authors.initials: RF
authors.lastname: Leitão
authors.affiliation: Department of Surgery, UFC, Fortaleza, CE, Brazil.
authors.forename: Paulo Roberto Leitão de
authors.initials: PR
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004338:Drug Combinations; D005227:Fatty Acids / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology / Q000627:therapeutic use; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis / Q000187:drug effects*; D008297:Male; D016328:NF-kappa B / Q000032:analysis / Q000187:drug effects*; D011897:Random Allocation; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012624:Seaweed / Q000737:chemistry*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D019394:Ki-67 Antigen; D016328:NF-kappa B