title: A prospective, randomized trial of pancreatectomy combined with isolated hepatic perfusion via a dual route or conventional postoperative adjuvant therapy in patients with advanced pancreatic head carcinoma.
abstract: Prognosis of locally advanced pancreatic head carcinoma after Whipple remains poor. This study is to investigate the efficacy and safety of regional lymphadenectomy and chemotherapy of isolated hypoxic perfusion (IHP) via dual-route, and to analyze the effect for survival period. Consecutive patients subjected to our department from January 1, 2006 to December 31 2011 for locally advanced pancreatic head carcinoma were prospectively divided into two groups according to therapeutic modality, and clinical and follow-up data was recorded. In study group, operation duration and postoperative stay time were shorter, blood loss and blood transfusion were less, and incidence of complications was lower. The mean and median survival time was 17.4 ± 0.76 months and 18.0 months in study group, longer than control group of 14.1 ± 0.85 months and 17.6 months. Regional lymphadenectomy can be performed with low mortality and morbidity, and combined postoperative IHP via dual-route can improve survival time.
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Kong
authors.affiliation: Institute of Aviation Medicine of Chinese PLA Air Force 28 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Dongqing
authors.initials: D
authors.lastname: Wen
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Chengli
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Xiao
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zhen
authors.affiliation: Department of Hepatobiliary Surgery, Chinese PLA Air Force General Hospital 30 Fucheng Rd, Haidian District, Beijing 100142, China.
authors.forename: Hongyi
authors.initials: H
authors.lastname: Zhang
keywords: Pancreatic carcinoma; Whipple; chemotherapy; isolated hypoxic perfusion; lymphadenectomy