title: Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera.
abstract: New multipinhole cadmium-zinc-telluride (CZT) cameras allow for faster imaging and lower radiation doses for single photon emission computed tomography (SPECT) studies, but assessment of prognostic ability is necessary.
  
  
  
  We collected data from all myocardial SPECT perfusion studies performed over 15 months at our institution, using either a CZT or conventional Anger camera. A Cox proportional hazards model was used to assess the relationship between camera type, imaging results, and either death or myocardial infarction (MI). Clinical variables including age, sex, body mass index (BMI), and historical risk factors were used for population description and model adjustments. We had 2,088 patients with a total of 69 deaths and 65 MIs (122 events altogether). A 3% increase in DDB (difference defect burden) represented a 12% increase in the risk of death or MI, whereas a 3% increase in rest defect burden or stress defect burden represented an 8% increase; these risks were the same for both cameras (P > .24, interaction tests).
  
  
  
  The CZT camera has similar prognostic values for death and MI to conventional Anger cameras. This suggests that it may successfully be used to decrease patient dose.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Road, Durham, NC, 27710, USA. joldan9@gmail.com.|, 11328 Euclid Avenue, Apt. 303, Cleveland, OH, 44106, USA. joldan9@gmail.com.
authors.forename: Jorge Daniel
authors.initials: JD
authors.lastname: Oldan
authors.affiliation: Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC, 27705, USA.
authors.forename: Linda K
authors.initials: LK
authors.lastname: Shaw
authors.affiliation: Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC, 27705, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Hofmann
authors.affiliation: Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC, 27705, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Phelan
authors.affiliation: Clinical Imaging Physics Group, Department of Radiology, Duke University Medical Center, Durham, NC, 27705, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Nelson
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Road, Durham, NC, 27710, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Pagnanelli
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Road, Durham, NC, 27710, USA.
authors.forename: Salvador
authors.initials: S
authors.lastname: Borges-Neto
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D015902:Gamma Cameras / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000401:mortality*; D055414:Myocardial Perfusion Imaging / Q000295:instrumentation* / Q000706:statistics & numerical data; D009657:North Carolina / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D016019:Survival Analysis; D013691:Tellurium; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*; D055815:Young Adult; D015032:Zinc
chemical_list: C474490:CdZnTe; D002104:Cadmium; D015032:Zinc; D013691:Tellurium
keywords: CZT; Evidence-based medicine; SPECT; outcomes; solid-state camera