title: Association between interleukin gene polymorphisms and risk of recurrent oral ulceration.
abstract: We conducted a case-control study to investigate the association between the functional IL-1β+3954 (C/T), IL-6-174 (G/C), IL-10-1082 (G/A), and IL-10-819C/T genetic polymorphisms and risk of recurrent oral ulceration (ROU) in a Chinese population. Polymorphisms of IL-1β+3954C/T, IL-6-174G/C, IL-10-1082A/G and IL-10-819C/T were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-1β+3954 C/T and IL-10-819C/T were in Hardy-Weinberg equilibrium in the control group. Conditional logistic regression analyses showed that subjects carrying the IL-1β+3954CC and IL-10-1082AA genotypes had a significantly increased risk of ROU, with adjusted ORs (95%CI) of 2.86 (1.37-6.33) and 1.72 (1.02-2.89), respectively. In summary, we found that IL-1β+3954C/T and IL-10-1082A/G polymorphisms are associated with an increased risk of ROU.
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of PLA General Hospital, Beijing, China.
authors.forename: C
authors.initials: C
authors.lastname: Jing
authors.affiliation: Department of Stomatology, The First Affiliated Hospital of PLA General Hospital, Beijing, China zhangjianqiang54@163.com.
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012008:Recurrence; D012306:Risk
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D016753:Interleukin-10