title: Adipose-derived stem cells: A candidate for liver regeneration.
abstract: The scarcity of donor livers and the impracticality of hepatocyte transplantation represent the biggest obstacles for the treatment of liver failure. Adipose-derived stem cells, with their ability to differentiate into the hepatic lineage, provide a reliable alternative cell source with clear ethical and practical advantages. Moreover, adipose-derived stem cells can effectively repair liver damage by the dominant indirect pattern and increase the number of hepatocytes by the secondary direct pattern. In recent years, the development of the indirect pattern, which mainly includes immunomodulatory and trophic effects, has become a hot topic in the field of cell engineering. Therefore, adipose-derived stem cells are considered to be ideal therapeutic stem cells for human liver regeneration. In this article, we reviewed the advantages of adipose-derived stem cells in liver regeneration, and explore their underlying mechanisms.
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Zhong Qiong
authors.initials: ZQ
authors.lastname: Wang
authors.affiliation: School of Foreign Languages of Sichuan Medical University, Luzhou, Sichuan Province, China.
authors.forename: Jia Qi
authors.initials: JQ
authors.lastname: Deng
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Jing Yuan
authors.initials: JY
authors.lastname: Liao
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pediatric Surgery, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Ming Ming
authors.initials: MM
authors.lastname: Deng
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors.forename: Mu Han
authors.initials: MH
authors.lastname: Lü
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D008107:Liver Diseases / Q000628:therapy*; D008115:Liver Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*
keywords: adipose-derived stem cells; bone marrow-derived stem cells; hepatocyte-like cells; liver damage; liver regeneration