title: CROSSTALK BETWEEN VITAMIN B AND IMMUNITY.
abstract: Vitamin B1 (thiamin) is considered to be the oldest vitamin and in 1936 R.R. Williams and colleagues determined its chemical structure and were able to synthesize this vitamin. Vitamin B1 influences pro-apoptotic proteins, mitochondrial membrane potential, cytochrome C release, protein kinases, p38-MAPK, suppresses oxidative stress-induced NF-kappaB and has anti-inflammatory properties. Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons. Here we report the relationship between vitamin B complex and immunity.
authors.affiliation: Department of Surgery and Odontostomatological Sciences, University of Cagliari, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Spinas
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.affiliation: Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: S K
authors.initials: SK
authors.lastname: Kritas
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.affiliation: Orthopedic Division, University of Chieti-Pescara, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pantalone
authors.affiliation: Aristotelian University, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Frydas
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tei
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Speziali
authors.affiliation: Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. dAnnunzio University Chieti-Pescara, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Saggini
authors.affiliation: Catholic University of Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.affiliation: Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Conti
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology; D023421:Models, Animal; D009422:Nervous System Diseases / Q000209:etiology / Q000276:immunology; D009468:Neuromuscular Diseases / Q000209:etiology / Q000276:immunology; D014803:Vitamin B Complex / Q000502:physiology* / Q000627:therapeutic use; D014804:Vitamin B Deficiency / Q000150:complications / Q000276:immunology*
chemical_list: D016207:Cytokines; D014803:Vitamin B Complex