title: Hyperscape: visualization for complex biological networks.
abstract: BACKGROUND
  Network biology has emerged as a powerful tool to uncover the organizational properties of living systems through the application of graph theoretic approaches. However, due to limitations in underlying data models and visualization software, knowledge relating to large molecular assemblies and biologically active fragments is poorly represented.
  
  
  RESULTS
  Here, we demonstrate a novel hypergraph implementation that better captures hierarchical structures, using components of elastic fibers and chromatin modification as models. These reveal unprecedented views of the biology of these systems, demonstrating the unique capacity of hypergraphs to resolve overlaps and uncover new insights into the subfunctionalization of variant complexes.
  
  
  METHODS
  Hyperscape is available as a web application at http://www.compsysbio.org/hyperscape. Source code, examples and a tutorial are freely available under a GNU license.
  
  
  BACKGROUND
  john.parkinson@utoronto.ca or graham.cromar@gmail.com
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, 21-9830 PGCRL, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Cromar
authors.affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, 21-9830 PGCRL, 686 Bay Street, Toronto, ON, M5G 0A4, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Zhao
authors.affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, 21-9830 PGCRL, 686 Bay Street, Toronto, ON, M5G 0A4, Canada, Department of Biochemistry and.
authors.forename: Alex
authors.initials: A
authors.lastname: Yang
authors.affiliation: Program in Molecular Structure and Function, Hospital for Sick Children, 21-9830 PGCRL, 686 Bay Street, Toronto, ON, M5G 0A4, Canada, Department of Biochemistry and Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.
authors.forename: John
authors.initials: J
authors.lastname: Parkinson
mesh_terms: D002843:Chromatin / Q000378:metabolism; D003196:Computer Graphics; D004547:Elastic Tissue / Q000378:metabolism; D012984:Software; D049490:Systems Biology
chemical_list: D002843:Chromatin