title: Eculizumab and drug-induced haemolytic-uraemic syndrome.
abstract: The monoclonal anti-C5 antibody eculizumab has been successfully tested in atypical haemolytic-uraemic syndrome (aHUS), with or without mutations in the regulatory proteins of the alternative pathway of the complement, and less convincingly in enterohaemorrhagic Escherichia coli-associated HUS. Here, we report a patient with mitomycin-C-induced HUS unresponsive to plasma exchanges. Eculizumab infusion was followed by a dramatic improvement of haematological parameters and renal function, suggesting a role of complement blockade in the management of refractory, drug-related HUS.
authors.affiliation: Nephrology and Transplantation Department , University Hospital Rangueil and University Toulouse-3 , Toulouse , France ; Reference Center for Rare Renal Diseases , University Hospital Rangueil , Toulouse , France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Faguer
authors.affiliation: Nephrology and Transplantation Department , University Hospital Rangueil and University Toulouse-3 , Toulouse , France ; Reference Center for Rare Renal Diseases , University Hospital Rangueil , Toulouse , France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Huart
authors.affiliation: Cordeliers Research Center , INSERM UMRS872 and Immunology Laboratory, Hôpital Européen-Georges Pompidou, AP-HP , Paris , France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Frémeaux-Bacchi
authors.affiliation: Nephrology and Transplantation Department , University Hospital Rangueil and University Toulouse-3 , Toulouse , France ; Reference Center for Rare Renal Diseases , University Hospital Rangueil , Toulouse , France.
authors.forename: David
authors.initials: D
authors.lastname: Ribes
authors.affiliation: Nephrology and Transplantation Department , University Hospital Rangueil and University Toulouse-3 , Toulouse , France ; Reference Center for Rare Renal Diseases , University Hospital Rangueil , Toulouse , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Chauveau
keywords: drugs; eculizumab; haemolytic-uraemic syndrome