title: D-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats.
abstract: d-Fagomine is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. This suggests that supplementation with d-fagomine for longer periods may delay the onset of other factors related to metabolic syndrome. Here we evaluate the effects of d-fagomine dietary supplementation on relevant metabolic hormones and lipid peroxidation. Adult Sprague-Dawley rats were fed a high-fat high-sucrose diet supplemented or not with d-fagomine (0.065% w/w) for 9 weeks. Weight gain, plasma triglycerides, glucose, insulin, glucagon, ghrelin, leptin, and urine F2-isoprostanes were evaluated. d-Fagomine attenuated the changes induced by the high-energy-dense diet in triglycerides and all the hormones tested. These results suggest that d-fagomine may help to avert the complications associated with unhealthy eating by counteracting the effects of high-energy-dense diets during the early stages of the development of metabolic disorders.
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain. sara.ramos@iqac.csic.es.
authors.forename: Eunice
authors.initials: E
authors.lastname: Molinar-Toribio
authors.forename: Jara
authors.initials: J
authors.lastname: Pérez-Jiménez
authors.forename: Sara
authors.initials: S
authors.lastname: Ramos-Romero
authors.forename: Livia
authors.initials: L
authors.lastname: Gómez
authors.forename: Núria
authors.initials: N
authors.lastname: Taltavull
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Nogués
authors.forename: Alberto
authors.initials: A
authors.lastname: Adeva
authors.forename: Olga
authors.initials: O
authors.lastname: Jáuregui
authors.forename: Jesús
authors.initials: J
authors.lastname: Joglar
authors.forename: Pere
authors.initials: P
authors.lastname: Clapés
authors.forename: Josep Lluís
authors.initials: JL
authors.lastname: Torres
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D059305:Diet, High-Fat / Q000009:adverse effects; D006801:Humans; D050112:Imino Pyranoses / Q000008:administration & dosage*; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D050112:Imino Pyranoses; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; C105643:fagomine