title: Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother.
abstract: Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.
authors.affiliation: Department of Microbiology and Virology, Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zavattoni
authors.affiliation: Departments of Obstetrics and Gynecology, "V.Buzzi" Hospital, ICP, University of Milan, Milan, Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Rustico
authors.affiliation: Obstetric and Gynecology Unit, Fondazione IRCCS Ospedale Maggiore Policlinico di Milano, Milan, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Tassis
authors.affiliation: Neonatology and Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Lombardi
authors.affiliation: Department of Microbiology and Virology, Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Furione
authors.affiliation: Department of Microbiology and Virology, Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Piralla
authors.affiliation: Department of Microbiology and Virology, Molecular Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.|Department of Clinical, Section of Microbiology, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Baldanti
mesh_terms: D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000635:transmission*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011296:Prenatal Diagnosis; D018570:Risk Assessment; D013997:Time Factors
keywords: amniocentesis; congenital disease; human cytomegalovirus; maternal infection