title: Preparation and characterization of erythromycin molecularly imprinted polymers based on distillation-precipitation polymerization.
abstract: Erythromycin-imprinted polymers with excellent recognition properties were prepared by an innovative strategy called distillation-precipitation polymerization. The interaction between erythromycin and methacrylic acid was studied by ultraviolet absorption spectroscopy, and the as-prepared materials were characterized by Fourier-transform infrared spectroscopy and scanning electron microscopy. Moreover, their binding performances were evaluated in detail by static, kinetic and selective sorption tests. It was found that the molecularly imprinted polymers afforded good morphology, monodispersity, and high adsorption capacity when the fraction of the monomers was 7 vol% in the whole reaction system, and the adsorption data for imprinted polymers correlated well with the Langmuir model. The maximum capacity of the imprinted and the non-imprinted polymers for adsorbing erythromycin is 44.03 and 19.95 mg/g, respectively. The kinetic studies revealed that the adsorption process fitted a pseudo-second-order kinetic model. Furthermore, the imprinted polymers display higher affinity toward erythromycin, compared with its analogue roxithromycin.
authors.affiliation: Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education; School of Pharmacy, Shihezi University, Shihezi 832002, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education; School of Pharmacy, Shihezi University, Shihezi 832002, China.
authors.forename: Le
authors.initials: L
authors.lastname: Li
authors.affiliation: Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education; School of Pharmacy, Shihezi University, Shihezi 832002, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
authors.affiliation: Jiangsu Devote Instrumental Science & Technology Co., Ltd, Huai'an, China.
authors.forename: Feilang
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China.
authors.forename: Bang-Ce
authors.initials: BC
authors.lastname: Ye
authors.affiliation: Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education; School of Pharmacy, Shihezi University, Shihezi 832002, China.|Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
mesh_terms: D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D057168:Distillation; D004917:Erythromycin / Q000737:chemistry*; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting / Q000379:methods*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D015575:Roxithromycin / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D008689:Methacrylates; D011108:Polymers; D012997:Solvents; C008384:methacrylic acid; D015575:Roxithromycin; D004917:Erythromycin
keywords: Distillation-precipitation polymerization; Equilibrium; Erythromycin; Kinetics; Molecularly imprinted polymers