title: [New transmission scenarios of the Argentine hemorrhagic fever since the introduction of the live attenuated junin virus vaccine (Candid #1): an experience in migrant workers].
abstract: The Argentine hemorrhagic fever (AHF) is a severe acute viral disease caused by the Junin virus of the Arenaviridae family. The AHF endemic area coincides geographically with the largest grain export agro-industrial complex of the country [Argentina]. Since the implementation of vaccination with the Candid #1 vaccine, a significant reduction in incidence was achieved and risk patterns were modified. A previous study allowed characterizing these changes and identifying three transmission scenarios: classic, emergent-reemergent, and traveler. The latter scenario includes seasonal migrant workers who move each year, mainly from the province of Santiago del Estero, the endemic area to work in the detasseling of maize. With the objective of protecting this group of workers, a prevention campaign was initiated which included: capacity building of health personnel in the province, health education, and immunization with the vaccine Candid #1. 3,021 workers were vaccinated. Prior to vaccination, serum samples were taken from a group of 104 volunteers. Tests for neutralizing antibodies specific to the Junin virus were performed and 6 (5.76%) tested positive. The unexpected finding of a high percentage of workers with antibodies suggests the need to evaluate several hypotheses: a) that the result is the product of non-probabilistic sampling; b) that it could be people who fell ill in previous travels, c) or who were vaccinated in previous travels; or d) consider this region as an emerging scenario.
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui, Pergamino, Argentina.
authors.forename: Ana
authors.initials: A
authors.lastname: Briggiler
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui, Pergamino, Argentina.
authors.forename: Anabel
authors.initials: A
authors.lastname: Sinchi
authors.affiliation: Programa Ampliado de Inmunizaciones, Ministerio de Salud de Santiago del Estero, Argentina.
authors.forename: Florencia
authors.initials: F
authors.lastname: Coronel
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui, Pergamino, Argentina.
authors.forename: Zaida
authors.initials: Z
authors.lastname: Sánchez
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui, Pergamino, Argentina.
authors.forename: Silvana
authors.initials: S
authors.lastname: Levis
authors.affiliation: Registro Nacional de Trabajadores y Empleadores Agrarios, Argentina.
authors.forename: Jorge
authors.initials: J
authors.lastname: Taylor
authors.affiliation: Instituto Nacional de Enfermedades Virales Humanas Dr. Julio Maiztegui, Pergamino, Argentina.
authors.forename: Delia
authors.initials: D
authors.lastname: Enria
mesh_terms: D000382:Agricultural Workers' Diseases / Q000517:prevention & control* / Q000821:virology*; D001118:Argentina; D005260:Female; D006478:Hemorrhagic Fever, American / Q000517:prevention & control* / Q000635:transmission*; D006801:Humans; D018051:Junin virus / Q000276:immunology*; D008297:Male; D014171:Transients and Migrants; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines