title: Comparison of Malated Ringer's with Two Other Balanced Crystalloid Solutions in Resuscitation of Both Severe and Moderate Hemorrhagic Shock in Rats.
abstract: In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison to lactated and acetated Ringer's. Male Wistar rats underwent severe (mean arterial blood pressure (MAP) of 25-30 mmHg) or moderate (MAP 40-45 mmHg) hemorrhagic shock. Adjacent to the shock period animals were resuscitated with acetated (AR), lactated (LR), or malated Ringer's (MR) and observed for 150 min. MR improved survival compared with LR and AR in severe hemorrhagic shock whereas it was equally effective to LR and superior to AR in moderate hemorrhagic shock. In all other parameters tested, MR was also effective similar to the other solutions under these conditions. We conclude that MR is preferable to AR and LR in resuscitation of hemorrhagic shock independent of shock depth. The positive effects of MR may stem from the absence of any adverse impact on energy metabolism under both conditions.
authors.affiliation: Department for Trauma Surgery and Orthopaedics, University Hospital Essen, 45147 Essen, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Keitel
authors.affiliation: Department for Trauma Surgery and Orthopaedics, University Hospital Essen, 45147 Essen, Germany.
authors.forename: Bjoern
authors.identifier: 0000-0001-8333-6367
authors.initials: B
authors.lastname: Hussmann
authors.affiliation: Department for Trauma Surgery and Orthopaedics, University Hospital Essen, 45147 Essen, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Lendemans
authors.affiliation: Institute of Physiological Chemistry, University Hospital Essen, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: de Groot
authors.affiliation: Institute of Physiological Chemistry, University Hospital Essen, Germany.
authors.forename: Ricarda
authors.initials: R
authors.lastname: Rohrig
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D000077324:Crystalloid Solutions; D004195:Disease Models, Animal; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000009:adverse effects*; D019344:Lactic Acid / Q000008:administration & dosage / Q000009:adverse effects; D008293:Malates / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D051381:Rats; D012151:Resuscitation; D000077331:Ringer's Solution; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D008293:Malates; D019344:Lactic Acid; D000077331:Ringer's Solution