title: Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration.
abstract: OBJECTIVE
  To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus (TM) OCT, and the Spectral Domain (SD-OCT) Spectralis (TM) and Cirrus (TM) OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  
  
  
  METHODS
  University-based retina practice.
  
  
  METHODS
  Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD.
  
  
  METHODS
  OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices.
  
  
  METHODS
  Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability.
  
  
  RESULTS
  Spectralis had the highest number of images needing manual correction.  All machines had high ICCs, with Spectralis having the highest.  Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™.  The CORs were lowest for Spectralis (TM) and similar and higher for Cirrus (TM) and Stratus (TM).  Agreement, CORs, and ICCs generally improved after manual correction, but only minimally.
  
  
  CONCLUSIONS
  Agreement is low between devices, except between both SD-OCT machines.  Manual correction tends to improve results.
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Sadiq
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Aymen
authors.initials: A
authors.lastname: Rashid
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Roomasa
authors.initials: R
authors.lastname: Channa
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Elham
authors.initials: E
authors.lastname: Hatef
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: Ocular Imaging Research and Reading Center (OIRRC), Stanley M Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
authors.forename: Yasir J
authors.initials: YJ
authors.lastname: Sepah
keywords: age related macular degeneration; neovascularization; optical coherence tomography; spectral domain; time domain