title: Effects of a Multi-Disciplinary Lifestyle Intervention on Cardiometabolic Risk Factors in Young Women with Abdominal Obesity: A Randomised Controlled Trial.
abstract: BACKGROUND
  Young women are under-represented in cardiovascular disease research, with obesity and cardiometabolic risk factor interventions generally targeting older adults. Furthermore, appropriate study designs for young women remain uncertain. This study aimed to assess the impact of a 12 week multi-disciplinary lifestyle intervention on cardiometabolic risk factors in premenopausal women with abdominal obesity.
  
  
  METHODS
  Women aged 18-30 y with abdominal obesity [waist circumference (WC) ≥ 80 cm] were randomised to a 12 week lifestyle intervention (n = 26) of physical activity, nutrition education and cognitive behavioural therapy, or a wait-list control group (n = 17). Both groups completed anthropometric, biochemical, nutrition and fitness testing, at pre (0 weeks) and post (12 weeks), with intervention participants completed follow-up testing at 24 weeks.
  
  
  RESULTS
  Results from a linear mixed model showed no between-group differences, other than increased physical activity in the intervention group, at post. In the intervention group alone, positive within-group changes were observed in WC, waist-hip-ratio (WHR), waist-height-ratio (WHtR), resting heart rate, blood pressure, predicted VO2max, and total energy intake. Most changes were maintained at 24 weeks post-intervention. Similar within-group improvements were observed in control participants in WC, WHR, WHtR, and systolic blood pressure but no changes were detected in physical activity and nutrition.
  
  
  CONCLUSIONS
  Cardiometabolic risk factors were decreased as a result of a lifestyle intervention in young women with abdominal obesity. It is difficult to describe observations in the control group without greater understanding of the behaviour of wait-list participants.
  
  
  BACKGROUND
  Australian New Zealand Clinical Trials Registry ACTRN12612001017819.
authors.affiliation: School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia.
authors.forename: Bianca L
authors.initials: BL
authors.lastname: Share
authors.affiliation: School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia; Murdoch Childrens Research Institute, Melbourne, Victoria, Australia.
authors.forename: Geraldine A
authors.initials: GA
authors.lastname: Naughton
authors.affiliation: School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia; LAPEC, EA4278, University of Avignon, Avignon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Obert
authors.affiliation: Faculty of Health Sciences, Australian Catholic University, Sydney, NSW, Australia.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Peat
authors.affiliation: School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Aumand
authors.affiliation: School of Exercise Science, Australian Catholic University, Melbourne, Victoria, Australia.
authors.forename: Justin G
authors.initials: JG
authors.lastname: Kemp
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D018479:Early Intervention, Educational; D005260:Female; D006801:Humans; D008019:Life Style; D056128:Obesity, Abdominal / Q000150:complications* / Q000453:epidemiology* / Q000517:prevention & control; D017063:Outcome Assessment, Health Care; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult