title: Effect of Weight Loss Induced by Intragastric Balloon Therapy on Cardiac Function in Morbidly Obese Individuals: A Pilot Study.
abstract: OBJECTIVE
  The aim of the study was to investigate the effect of intragastric balloon therapy on left ventricular function and left ventricular mass in a cohort of morbidly obese patients.
  
  
  METHODS
  A prospective trial was performed in a cohort of 17 class II and class III morbidly obese individuals. The intragastric balloon was retained in the stomach for an average of 6 months. Conventional and tissue Doppler echocardiography were performed in all patients before and after the procedure.
  
  
  RESULTS
  The mean age of the study participants was 36 ± 10 years (range: 18-55). The mean body mass index was significantly decreased following the intragastric balloon insertion procedure (44 ± 8 vs. 38 ± 5, p < 0.001). The left ventricular mass index and left atrial volume index were significantly decreased following the procedure (112 ± 21 vs. 93 ± 17, p = 0.001 and 20 ± 6 vs. 14 ± 5, p = 0.02, respectfully). In addition, the ratio of mitral peak early diastolic velocity to tissue Doppler-derived peak diastolic velocity and tissue Doppler echocardiography-derived left ventricular myocardial performance index were decreased significantly following the procedure (9.5 ± 1.9 vs. 7.7 ± 1.5, p = 0.002 and 0.57 ± 0.11 vs. 0.46 ± 0.06, p = 0.001, respectively).
  
  
  CONCLUSIONS
  Intragastric balloon therapy resulted in significant weight reduction in morbidly obese patients. This weight reduction was associated with improved left ventricular function.
authors.affiliation: Department of Cardiology, Akdeniz University School of Medicine, Antalya, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Koc
authors.forename: Huseyin Ayhan
authors.initials: HA
authors.lastname: Kayaoglu
authors.forename: Atac
authors.initials: A
authors.lastname: Celik
authors.forename: Fatih
authors.initials: F
authors.lastname: Altunkas
authors.forename: Metin
authors.initials: M
authors.lastname: Karayakali
authors.forename: Kerem
authors.initials: K
authors.lastname: Ozbek
authors.forename: Kayihan
authors.initials: K
authors.lastname: Karaman
authors.forename: Hasan
authors.initials: H
authors.lastname: Kadi
authors.forename: Erdinc
authors.initials: E
authors.lastname: Yenidogan
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D015992:Body Mass Index; D002302:Cardiac Output; D015150:Echocardiography, Doppler; D005260:Female; D015905:Gastric Balloon; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D010865:Pilot Projects; D011446:Prospective Studies; D016277:Ventricular Function, Left; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult