title: Successful living donor liver transplantation of fulminant liver failure due to isoniazid prophylaxis.
abstract: Progressive liver failure is rarely seen in tuberculosis chemoprophylaxis with isoniazid. We present a case of a 32-year-old woman admitted to our clinic reporting abdominal pain, nausea and vomiting for 2 days. The initial diagnosis was fulminant toxic hepatitis due to isoniazid chemoprophylaxis, which was treated successfully with living donor transplantation. Tuberculosis continues to be a significant public health problem. Isoniazid-related hepatotoxicity is extremely rare in adults. The only treatment in cases of fulminant liver failure is orthotopic liver transplantation from a deceased or living donor. If a deceased donor is not available or the patient refuses this treatment, living donor transplantation is the only choice. Although rare, isoniazid used as protective therapy for pulmonary tuberculosis can lead to fulminant liver failure. When cadaveric liver transplantation is not available, living donor liver transplantation is vital.
authors.affiliation: Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Tuğrul
authors.initials: T
authors.lastname: Çakır
authors.affiliation: Department of General Surgery, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ara
authors.affiliation: Department of General Surgery, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Hacı Vural
authors.initials: HV
authors.lastname: Soyer
authors.affiliation: Department of General Surgery, Faculty of Medicine, Inonu University, Malatya, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Koc
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D014376:Tuberculosis / Q000517:prevention & control
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid