title: Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras.
abstract: Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. clayden@man.ac.uk.
authors.forename: Julien
authors.initials: J
authors.lastname: Maury
authors.forename: Bryden A F
authors.initials: BA
authors.lastname: Le Bailly
authors.forename: James
authors.initials: J
authors.lastname: Raftery
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clayden
mesh_terms: D000577:Amides / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D014508:Urea / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000577:Amides; D014508:Urea