title: Association between the polymorphism of C861G (rs6296) in the serotonin 1B receptor gene and Tourette syndrome in Han Chinese people.
abstract: BACKGROUND
  Clinical, neuroimaging and other studies provided evidence that the dysfunction of the serotonin neurotransmitter system were found in Tourette syndrome (TS). This study is to explore the association between the polymorphism of C861G (rs6296) in HTR1B and TS in Han Chinese people.
  
  
  METHODS
  Two hundred ninety-nine TS patients (260 TS trios and 39 TS patients) and 388 healthy controls were collected. The genotype of HTR1B C861G was detected using Taqman probes. The case-control study and family-based study was used separately to study association between HTR1B C861G and TS in Han Chinese people.
  
  
  RESULTS
  In case-control study, no statistically significant difference was found in the distribution of HTR1B C861G polymorphism between TS patients and controls (for genotype: χ2= 3.408, P = 0.182; for allele: χ2= 0.395, P = 0.530, OR = 0.934, 95%CI: 0.754-1.156). In family-based study, we observed nonsignificant over-transmission of the G861 allele in HTR1B to TS offspring using the transmission disequilibrium test (TDT), haplotype relative risk (HRR) and haplotype-based HRR (HHRR) (TDT χ2= 0.410, P = 0.560; HRR = 1.151, χ2= 0.421, P = 0.517, 95% CI: 0.753-1.759; HHRR = 0.919, χ2= 0.467, P = 0.495, 95%CI: 0.720-1.172).
  
  
  CONCLUSIONS
  Our study suggested that the polymorphism of HTR1B C861G is not a risk factor for TS in Han Chinese population. However, the result should be replicated in larger sample and different population.
authors.affiliation: Department of Child Health Care, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Mingji
authors.initials: M
authors.lastname: Yi
authors.affiliation: Department of Child Health Care, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Clinical Laboratory, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, Qingdao Women and Children Medical Health Care Center, Qingdao, China.
authors.forename: Nailun
authors.initials: N
authors.lastname: Su
authors.affiliation: Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D005879:Tourette Syndrome / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
chemical_list: C470302:HTR1B protein, human; D044302:Receptor, Serotonin, 5-HT1B
keywords: HRR; HTR1B C861G (rs6296); TDT; Tourette syndrome; case-control study