title: Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy.
abstract: Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.
authors.affiliation: Department of Hematology, Faculty of Medicine, University of Tsukuba.
authors.forename: Chieko
authors.initials: C
authors.lastname: Kyogoku
authors.forename: Masanori
authors.initials: M
authors.lastname: Seki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ogawa
authors.forename: Kana
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Yufu
authors.initials: Y
authors.lastname: Ito
authors.forename: Naoki
authors.initials: N
authors.lastname: Kurita
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Mamiko
authors.initials: M
authors.lastname: Sakata-Yanagimoto
authors.forename: Naoshi
authors.initials: N
authors.lastname: Obara
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Fujishima
authors.forename: Ryo
authors.initials: R
authors.lastname: Ichinohasama
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shigeru
authors.initials: S
authors.lastname: Chiba
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D001761:Bleomycin / Q000627:therapeutic use; D003606:Dacarbazine / Q000627:therapeutic use; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D004317:Doxorubicin / Q000627:therapeutic use; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012074:Remission Induction; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D019788:Fluorodeoxyglucose F18; D001761:Bleomycin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin