title: Adiponectin is down-regulated in bone marrow interstitial fluid in hematological malignancy.
abstract: Adipokines play a role in carcinogenesis in a variety of malignancies. These findings were established with regard to serum adipokines and malignancies. However, the expression of adipokines in bone marrow fluid remains unclear, and an investigation of the correlation between bone marrow adipokines and hematological malignancy is needed. The present study was designed to detect adipokine concentrations, including adiponectin, leptin and resistin, in bone marrow interstitial fluid from patients with hematological malignancy and controlled counterparts. The correlations between adipokines, body mass index, clinical parameters, and hematological malignancy were assessed. A total of 80 bone marrow samples were assessed for values of adipokines, adiponectin, leptin and resistin. Patients with hematological malignancy had lower levels of adiponectin. Adiponectin from leukemia bone marrow expressed significantly low values. The adiponectin levels were inversely correlated with body mass index. In conclusion, adiponectin was decreased in bone marrow from patients with leukemia and negatively correlated with body mass index.
authors.affiliation: Department of Internal Medicine, Chi-Mei Medical Center, Yong Kang, Tainan, Taiwan.
authors.forename: Fan-Yu
authors.initials: FY
authors.lastname: Lin
authors.forename: Hung-Chang
authors.initials: HC
authors.lastname: Wu
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Cheng
authors.forename: Chao-Ling
authors.initials: CL
authors.lastname: Tung
authors.forename: Chi-Pei
authors.initials: CP
authors.lastname: Chang
authors.forename: Yin-Hsun
authors.initials: YH
authors.lastname: Feng
mesh_terms: D052242:Adiponectin / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001853:Bone Marrow / Q000378:metabolism*; D015536:Down-Regulation; D045604:Extracellular Fluid / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D009363:Neoplasm Proteins