title: How cells coordinate waste removal through their major proteolytic pathways.
abstract: The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin-proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.
authors.affiliation: Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, Vienna BioCenter, University of Vienna, A-1030 Vienna, Austria.
authors.forename: Sascha
authors.initials: S
authors.lastname: Martens
authors.affiliation: Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, Vienna BioCenter, University of Vienna, A-1030 Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bachmair
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D001120:Arginine / Q000378:metabolism*; D001343:Autophagy; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D006360:Heat-Shock Proteins; D001120:Arginine