title: Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation.
abstract: Dynamic hyperinflation (DH) has a significant adverse effect on cardiovascular function during exercise in COPD patients. COPD patients with (n = 25) and without (n = 11) exercise-induced DH undertook an incremental (IET) and a constant-load exercise test (CLET) sustained at 75% peak work (WRpeak) prior to and following an interval cycling exercise training regime (set at 100% WRpeak with 30-s work/30-s rest intervals) lasting for 12 weeks. Cardiac output (Q) was assessed by cardio-bio-impedance (PhysioFlow, enduro, PF-O7) to determine Q mean response time (QMRT) at onset (QMRT(ON)) and offset (QMRT(OFF)) of CLET. Post-rehabilitation only those patients exhibiting exercise-induced DH demonstrated significant reductions in QMRT(ON) (from 82.2 ± 4.3 to 61.7 ± 4.2 s) and QMRT(OFF) (from 80.5 ± 3.8 to 57.2 ± 4.9 s ). These post-rehabilitation adaptations were associated with improvements in inspiratory capacity, thereby suggesting that mitigation of the degree of exercise-induced DH improves central hemodynamic responses in COPD patients.
authors.affiliation: National and Kapodistrian University of Athens, Department of Physical Education and Sports Sciences, Athens, Greece; National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Nasis
authors.affiliation: National and Kapodistrian University of Athens, Department of Physical Education and Sports Sciences, Athens, Greece; Technological Educational Institute of Central Greece, Department of Physiotherapy, Lamia, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Kortianou
authors.affiliation: National and Kapodistrian University of Athens, Department of Physical Education and Sports Sciences, Athens, Greece; National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece.
authors.forename: Μ
authors.initials: Μ
authors.lastname: Vasilopoulou
authors.affiliation: National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Spetsioti
authors.affiliation: National and Kapodistrian University of Athens, Department of Physical Education and Sports Sciences, Athens, Greece.
authors.forename: Z
authors.initials: Z
authors.lastname: Louvaris
authors.affiliation: National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Kaltsakas
authors.affiliation: Cardiovascular Research Laboratory, Biomedical Research Foundation, Academy of Athens, Greece.
authors.forename: C H
authors.initials: CH
authors.lastname: Davos
authors.affiliation: National and Kapodistrian University of Athens, 1st Department of Critical Care Medicine, Evangelismos Hospital, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Zakynthinos
authors.affiliation: National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece.
authors.forename: N G
authors.initials: NG
authors.lastname: Koulouris
authors.affiliation: National and Kapodistrian University of Athens, Department of Physical Education and Sports Sciences, Athens, Greece; National and Kapodistrian University of Athens, 1st Department of Respiratory Medicine, Pulmonary Rehabilitation Unit, Sotiria Hospital, Athens, Greece; National and Kapodistrian University of Athens, 1st Department of Critical Care Medicine, Evangelismos Hospital, Greece. Electronic address: gianvog@phed.uoa.gr.
authors.forename: I
authors.initials: I
authors.lastname: Vogiatzis
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000368:Aged; D001642:Bicycling / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D015444:Exercise / Q000502:physiology; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000534:rehabilitation*; D012119:Respiration; D012120:Respiration Disorders / Q000503:physiopathology* / Q000534:rehabilitation*; D016896:Treatment Outcome
keywords: COPD; Cardiac output; Pulmonary rehabilitation