title: Impact of outpatient non-myeloablative haematopoietic stem cell transplantation in quality of life vs. conventional therapy.
abstract: The role of outpatient hematopoietic stem cell transplantation (HSCT) as a therapeutic tool has been strengthened significantly because of the increasing number of patients undergoing this treatment. Due the very nature of this procedure, one of the aspects that should not be overlooked is the quality of life (QOL) of patients undergoing HSCT. Thus, one must consider not only health status after treatment, but also, the psychosocial implications for the patient. This is an observational, longitudinal, and prospective study to assess QOL in patients undergoing outpatient HSCT vs. similar patients receiving medical treatment (MxTx). By applying the COOP/WONKA charts on five occasions (pre-HSCT/initial, post-HSCT/first month, and at 3, 6, and 9 months), thirty-eight patients were analysed, 19 with HSCT and 19 with MxTx with no differences in age, gender or diagnosis. The initial survey found significant differences only in pain perception, which was higher in the HSCT group (p = .08); at the first month, there was a greater tendency for feelings of depression or anxiety in the HSCT group (p = .016), with more limitations in social (p = .003) and daily (p = .044) activities. From 3 months post-HSCT, the results were very similar. The differences persisted only in the area of social activities. Four patients developed graft-versus-host disease with no significant difference in the scores obtained compared to other transplant patients at 3, 6, and 9 months (p = .26) of follow-up.
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: Olga Graciela
authors.initials: OG
authors.lastname: Cantú-Rodríguez
authors.affiliation: b Department of Internal Medicine , Hospital Universitario, Universidad Autónoma de Nuevo León , Monterrey , Mexico.
authors.forename: Mónica
authors.initials: M
authors.lastname: Sánchez-Cárdenas
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: Oscar Rubén
authors.initials: OR
authors.lastname: Treviño-Montemayor
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: Cesar Homero
authors.initials: CH
authors.lastname: Gutiérrez-Aguirre
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: Luz
authors.initials: L
authors.lastname: Tarín-Arzaga
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Jaime-Pérez
authors.affiliation: a Hematology Service , Hospital Universitario, Universidad Autónoma de Nuevo León , Madero y Gonzalitos Sn. Colonia Mitras Centro, C.P. 64460 Monterrey , Mexico.
authors.forename: David
authors.initials: D
authors.lastname: Gómez-Almaguer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D001007:Anxiety / Q000453:epidemiology; D003863:Depression / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology; D006402:Hematologic Diseases / Q000628:therapy*; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D058748:Pain Perception; D011446:Prospective Studies; D011788:Quality of Life; D058992:Social Participation / Q000523:psychology; D016896:Treatment Outcome; D055815:Young Adult
keywords: COOP–WONCA cards; GVHD; hematologic diseases; hematopoietic stem cell transplantation; quality of life; reduced-intensity conditioning