title: [Design, synthesis and anti-platelet aggregation activities of ligustrazine-tetrahydroisoquinoline derivatives].
abstract: Abstract: Fifteen novel ligustrazine-tetrahydroisoquinoline derivatives were designed and synthesized according to the association principle of pharmaceutical chemistry. The structures were identified by IR, NMR and ESI-MS. The inhibitory activities of platelet aggregation induced by ADP and AA have been measured by Bron method. Preliminary pharmacological results showed that compounds 7g, 7h and 7n had potent inhibitory activity against platelet aggregation induced by AA, and the compound 7o showed significant inhibitory activity against platelet aggregation induced by ADP.
authors.forename: Di
authors.initials: D
authors.lastname: Xie
authors.forename: En-li
authors.initials: EL
authors.lastname: Zhang
authors.forename: Jia-ming
authors.initials: JM
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Guang-wei
authors.initials: GW
authors.lastname: He
mesh_terms: D015195:Drug Design; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011719:Pyrazines; D044005:Tetrahydroisoquinolines; C017953:tetramethylpyrazine