title: Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics.
abstract: Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood-brain barrier by facilitating concentrated local therapeutic drug delivery with limited systemic effects. Here, we present a concise review of properties essential for safe and efficient convection-enhanced drug delivery, as well as a focused review of clinical studies evaluating CED in the treatment of glioblastoma.
authors.affiliation: Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Ung
authors.affiliation: Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Hani
authors.initials: H
authors.lastname: Malone
authors.affiliation: Department of Pathology & Cellular Biology, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Canoll
authors.affiliation: Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Bruce
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems / Q000295:instrumentation; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans
chemical_list: D000970:Antineoplastic Agents
keywords: convection-enhanced delivery; glioblastoma; glioma; high-grade glioma; targeted delivery of therapeutics for glioblastoma