title: Generalized vitiligo in a dog with primary hypoadrenocorticism.
abstract: BACKGROUND
  Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune-mediated destruction of the adrenal cortex.
  
  
  OBJECTIVE
  In this case report we describe a dog with primary hypoadrenocorticism that developed generalized vitiligo.
  
  
  METHODS
  A 4-year-old spayed female cross-bred dog developed signs of Addison's disease and this was confirmed by biochemical testing; the dog was treated with fludrocortisone acetate and then desoxycorticosterone pivalate. Three months after the diagnosis, the dog developed depigmentation of the whole hair coat and of several focal areas of the skin. Histopathological findings were consistent with vitiligo.
  
  
  CONCLUSIONS
  Dogs with immune-mediated disease may develop other manifestations of immune-mediated disease, including a combination of Addison's disease and vitiligo. The cause in this case was not determined.
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Malerba
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Morini
authors.affiliation: Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, 40064, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Fracassi
mesh_terms: D000224:Addison Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D003900:Desoxycorticosterone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004285:Dogs; D005260:Female; D005438:Fludrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014820:Vitiligo / Q000209:etiology / Q000662:veterinary*
chemical_list: C019323:deoxycortone pivalate; D003900:Desoxycorticosterone; D005438:Fludrocortisone; C034635:fludrocortisone acetate