title: One-pot synthesis of spiropyrroloquinoline-isoindolinone and their aza-analogs via the Ugi-4CR/metal-free intramolecular bis-annulation process.
abstract: This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.
authors.affiliation: School of Chemistry, College of Science, University of Tehran, Tehran, P.O. Box 14155 6455, Iran. Ghandi@khayam.ut.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ghandi
authors.forename: Nahid
authors.initials: N
authors.lastname: Zarezadeh
authors.forename: Alireza
authors.initials: A
authors.lastname: Abbasi
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001372:Aza Compounds; D054833:Isoindoles; D008670:Metals; D004364:Pharmaceutical Preparations; D011804:Quinolines; D013141:Spiro Compounds