title: Expectant management of severe preeclampsia with severe fetal growth restriction in the second trimester.
abstract: OBJECTIVE
  We investigated whether women with severe fetal growth restriction (FGR <5th percentile) associated with severe preeclampsia (PE) occurring in the second trimester are candidates for expectant management.
  
  
  METHODS
  This is a retrospective study involving 33 women who developed severe PE or superimposed PE in the second trimester and were expectantly managed at a tertiary center. They were divided into groups with and without severe FGR on admission (severe FGR (+) group: 17 women; severe FGR (-) group: 16 women) for comparison of the duration of pregnancy prolongation, major maternal complications, and perinatal outcomes. The data are presented as medians (range) or frequencies (percentage).
  
  
  RESULTS
  The duration of pregnancy prolongation was 10days in both groups. Major maternal complications occurred in 5 of 17 women (29.4%) in the severe FGR (+) and 5 of 16 (31.3%) in the severe FGR (-) group, showing very similar incidence rates in the 2 groups. The perinatal survival rates were favorable at 82.4% (14/17) in the severe FGR (+) and 100% (16/16) in the severe FGR (-) group.
  
  
  CONCLUSIONS
  Regarding expectant management of severe preeclampsia occurring in the second trimester, there was no difference in the duration of pregnancy prolongation between the groups with and without severe FGR on admission. Because favorable perinatal outcomes can be expected without compromising maternal safety by prolonging pregnancy as expectant management for severe FGR, it was suggested that women with severe FGR are suitable candidates for expectant management.
authors.affiliation: Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan. Electronic address: smyyaoki@yahoo.co.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Aoki
authors.affiliation: Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Toma
authors.affiliation: Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kurasawa
authors.affiliation: Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Okuda
authors.affiliation: Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Obstetrics and Gynecology, Yokohama City University Hospital, Yokohama, Japan.
authors.forename: Fumiki
authors.initials: F
authors.lastname: Hirahara
keywords: Expectant management; Pregnancy prolongation; Second trimester; Severe fetal growth restriction; Severe preeclampsia