title: Regulation of IgE Responses by γδ T Cells.
abstract: Immunoglobulin E (IgE) antibodies play a crucial role in host defense against parasite infections. However, inappropriate IgE responses are also involved in the pathogenesis of allergic diseases. The generation of IgE antibodies is a tightly controlled process regulated by multiple transcription factors, cytokines, and immune cells including γδ T cells. Accumulating evidence demonstrates that γδ T cells play a critical role in regulating IgE responses; however, both IgE-enhancing and IgE-suppressive effects are suggested for these cells in different experimental systems. In this review, we examine the available evidence and discuss the role of γδ T cells in IgE regulation both in the context of antigen-induced immune responses and in the state of partial immunodeficiency.
authors.affiliation: Department of Biomedical Research, National Jewish Health, Denver, CO, 80206, USA, huangy@njhealth.org.
authors.forename: Yafei
authors.initials: Y
authors.lastname: Huang
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Yang
authors.forename: Jessica
authors.initials: J
authors.lastname: McGowan
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: O'Brien
authors.forename: Willi K
authors.initials: WK
authors.lastname: Born
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D006801:Humans; D017578:Immunoglobulin Class Switching; D007073:Immunoglobulin E / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000941:Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; D007073:Immunoglobulin E