title: Mechanical and biocompatibility performance of bicomponent polyester/silk fibroin small-diameter arterial prostheses.
abstract: BACKGROUND
  In this study, we fabricated prototype bicomponent polyester/silk fibroin small-diameter arterial prostheses using a specially designed narrow ribbon shuttle loom.
  
  
  METHODS
  The 2-layered flat fabrics were then heatset on a mandrel to form tubes with a round cross section.
  
  
  RESULTS
  The woven samples had a wall thickness between 0.23 mm and 0.29 mm and an inner diameter between 3.53 mm and 3.95 mm, depending on the yarn type and the weave structure.
  
  
  CONCLUSIONS
  The bicomponent polyester/silk fibroin samples had superior bursting strength, circumferential strength and suture retention strength compared with a commercial small-diameter arterial prosthesis made from ePTFE. In addition, these prototype samples had greater suture retention strengths than a dog femoral artery, which indicates that they have adequate biostability for clinical use. While their amount of radial compliance was superior to that of the ePTFE commercial graft control, it did not match that of a natural artery. So there is still a need for future improvement in compliance. All of the woven prototypes had water permeability values between 26 and 180 ml/(cm(2)*min), which confirms that none of these arterial prostheses needs to be preclotted at the time of implantation. The biocompatibility of the woven prototypes was evaluated using porcine endothelial cells and an MTT assay. Their cytocompatibility was found to be superior to the ePTFE commercial control, and the level of cell attachment was observed to increase on these prototypes woven with a higher silk fibroin content.
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.|College of Textiles, North Carolina State University, Raleigh, North Carolina - USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Guoping
authors.initials: G
authors.lastname: Guan
authors.affiliation: Shanghai Medical College, Fudan University, Shanghai - PR China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Gaotian
authors.initials: G
authors.lastname: Shen
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Peng
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China.|College of Textiles, North Carolina State University, Raleigh, North Carolina - USA.
authors.forename: Martin W
authors.initials: MW
authors.lastname: King
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D001807:Blood Vessel Prosthesis; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D005263:Femoral Artery / Q000502:physiology; D005349:Fibroins / Q000737:chemistry*; D008422:Materials Testing; D011093:Polyethylene Terephthalates / Q000737:chemistry*; D011312:Pressure; D013552:Swine
chemical_list: D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D005349:Fibroins