title: β-lactam-associated eosinophilic colitis.
abstract: A 42-year-old man with a history of childhood asthma presented with a 2-week history of watery diarrhoea and marked peripheral eosinophilia in the setting of recent use of cephalexin. His colonoscopy revealed patchy colitis. Biopsies were consistent with eosinophilic colitis. Two months later he received a course of amoxicillin resulting in recurrence of peripheral eosinophilia. Given the time-frame of β-lactam administration to symptom onset and elimination of all other precipitating causes, he was diagnosed with β-lactam-associated eosinophilic colitis. The patient's symptoms resolved and peripheral eosinophil count decreased with no specific treatment. Eosinophilic colitis is a rare heterogeneous condition, the pathogenesis of which is likely to be an interplay between environmental and genetic factors. It can be secondary to a helminthic infection or a drug reaction and has been associated with ulcerative colitis. If secondary causes of eosinophilic colitis have been excluded, the mainstay of treatment is with corticosteroids.
authors.affiliation: Department of Medicine, The Northern Hospital, Epping, Victoria, Australia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Mogilevski
authors.affiliation: Department of Healthscope Pathology, The Northern Hospital, Melbourne, Victoria, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Nickless
authors.affiliation: Department of Infectious Diseases, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
authors.forename: Sam
authors.initials: S
authors.lastname: Hume
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000009:adverse effects*; D002506:Cephalexin / Q000008:administration & dosage / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D003967:Diarrhea / Q000209:etiology; D018450:Disease Progression; D004802:Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D065093:beta-Lactamase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000305:Adrenal Cortex Hormones; D065093:beta-Lactamase Inhibitors; D000658:Amoxicillin; D002506:Cephalexin