title: Triterpenoid saponins from the root bark of Schima superba and their cytotoxic activity on B16 melanoma cell line.
abstract: Eight new oleanane-type triterpenoid saponins, schisusaponins A-H, along with eight known triterpenoid saponins, were isolated from the root bark of Schima superb (Theaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. The cytotoxicity of the new compounds against B16 melanoma cells was assessed. Among the isolated new saponins, schisusaponins C and E showed more potent effects (with IC50 values of 10.08 and 10.89 μM) than vinblastine (with an IC50 value of 19.48 μM).
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China; XiaMen Medical College, Xiamen 361008, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wu
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China.
authors.forename: Rong-Liu
authors.initials: RL
authors.lastname: Zhang
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Li
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Hu
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China.
authors.forename: Bai-Lian
authors.initials: BL
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China. Electronic address: tliyl@jnu.edu.cn.
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.affiliation: College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, 601 West Huangpu Avenue, Guangzhou 510632, China. Electronic address: guangxzh@sina.com.
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D028242:Theaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes
keywords: Cytotoxicity; Oleanane-type triterpenoid saponins; Schima superb; Theaceae