title: Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.
abstract: The initiation, progression and cure of cancer rely heavily on altered gene expression and posttranslational functions. Protein ubiquitination is a major mechanism for posttranslational reorganization of the genome. This evolutionary conserved cascade, through regulation of protein stability, distribution, and function, governs nearly every biological process in the cell. E3 ubiquitin ligases are pivotal components of the ubiquitination pathway. Genetic alterations, abnormal expression, and dysfunctions of E3s have been implicated in the pathogenesis of a wide spectrum of human malignancies. In this review, we summarize and discuss recent discoveries on the roles of NEDD4 E3s in cancer. Over the past decade, members of this family have increasingly surfaced as fundamental components and critical regulators of molecular pathways central to the pathogenesis and cure of the disease.
authors.affiliation: Laboratory of Molecular and Cellular Cancer Biology, Faculty of Medicine, Bar-Ilan University, Safed, Israel.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zou
authors.affiliation: Laboratory of Molecular and Cellular Cancer Biology, Faculty of Medicine, Bar-Ilan University, Safed, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Levy-Cohen
authors.affiliation: Laboratory of Molecular and Cellular Cancer Biology, Faculty of Medicine, Bar-Ilan University, Safed, Israel. Electronic address: michael.blank@biu.ac.il.
authors.forename: Michael
authors.initials: M
authors.lastname: Blank
mesh_terms: D018450:Disease Progression; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D006801:Humans; D000075702:Nedd4 Ubiquitin Protein Ligases; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D000075702:Nedd4 Ubiquitin Protein Ligases; C000618483:Nedd4 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Carcinogenesis; Metastases; NEDD4 E3 ubiquitin ligases; Protein ubiquitination; Ubiquitin