title: Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery.
abstract: Oxidative stress is a pathomechanism causally linked to the progression of chronic cardiovascular diseases and diabetes. Mitochondria have emerged as the most relevant source of reactive oxygen species, the major culprit being classically considered the respiratory chain at the inner mitochondrial membrane. In the past decade, several experimental studies unequivocally demonstrated the contribution of monoamine oxidases (MAOs) at the outer mitochondrial membrane to the maladaptative ventricular hypertrophy and endothelial dysfunction. This paper addresses the contribution of mitochondrial dysfunction to the pathogenesis of heart failure and diabetes together with the mounting evidence for an emerging role of MAO inhibition as putative cardioprotective strategy in both conditions.
authors.affiliation: Department of Functional Sciences-Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Oana M
authors.initials: OM
authors.lastname: Duicu
authors.affiliation: Department of Microscopical Morphology-Histology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Rodica
authors.initials: R
authors.lastname: Lighezan
authors.affiliation: Department of Functional Sciences-Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Adrian
authors.initials: A
authors.lastname: Sturza
authors.affiliation: Department of Microscopical Morphology-Histology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Raluca A
authors.initials: RA
authors.lastname: Ceausu
authors.affiliation: Department of Functional Sciences-Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Claudia
authors.initials: C
authors.lastname: Borza
authors.affiliation: Department of Microscopical Morphology-Morphopathology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Adrian
authors.identifier: 0000-0001-9261-5309
authors.initials: A
authors.lastname: Vaduva
authors.affiliation: Department of Functional Sciences-Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Noveanu
authors.affiliation: Department of Cardiology-Cardiovascular Surgery, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Marian
authors.initials: M
authors.lastname: Gaspar
authors.affiliation: Department of Cardiology-2nd Cardiology Clinic, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Adina
authors.initials: A
authors.lastname: Ionac
authors.affiliation: Department of Cardiology-Cardiovascular Surgery, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Horea
authors.initials: H
authors.lastname: Feier
authors.affiliation: Department of Functional Sciences-Pathophysiology, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Danina M
authors.initials: DM
authors.lastname: Muntean
authors.affiliation: Department of Cardiology-2nd Cardiology Clinic, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
authors.forename: Cristian
authors.initials: C
authors.lastname: Mornos
mesh_terms: D048909:Diabetes Complications / Q000201:enzymology / Q000503:physiopathology; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects / Q000473:pathology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D013903:Thoracic Surgery
chemical_list: D008996:Monoamine Oxidase Inhibitors; D017382:Reactive Oxygen Species; D008995:Monoamine Oxidase