title: Selenite-Releasing Bone Mineral Nanoparticles Retard Bone Tumor Growth and Improve Healthy Tissue Functions In Vivo.
abstract: Selenite-doped bone mineral nanoparticles can retard the growth of osteosarcoma in a nude mice model, through sustained release of selenite ions. The selenite ions released from the nanoparticles through a degradation-mediated fashion inhibit tumor metastasis. Blood routine analysis indicates that selenite ions can also improve the functions of liver, kidney, and heart.
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Hao
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Haoming
authors.initials: H
authors.lastname: Liu
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430074, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Gaojie
authors.initials: G
authors.lastname: Yang
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma, 73019, USA.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
authors.affiliation: Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, 430074, China.|Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
authors.forename: Shengmin
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D015519:Bone Density / Q000187:drug effects*; D001859:Bone Neoplasms / Q000188:drug therapy*; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D020887:Selenious Acid / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite; D020887:Selenious Acid
keywords: bone minerals; hydroxyapatite; nanoparticles; osteosarcoma; selenite