title: Clinical Characteristics, Radiological Features and Gene Mutation in 10 Chinese Families with Spinocerebellar Ataxias.
abstract: BACKGROUND
  Spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders that primarily cause the degeneration in the cerebellum, spinal cord, and brainstem. We study the clinical characteristics, radiological features and gene mutation in Chinese families with SCAs.
  
  
  METHODS
  In this study, we investigated 10 SCAs Chinese families with SCA1, SCA3/Machado-Joseph disease (MJD), SCA7, SCA8. There were 27 people who were genetically diagnosed as SCA, of which 21 people showed clinical symptoms, and 6 people had no clinical phenotype that we called them presymptomatic patients. In addition, 3 people with cerebellar ataxia and cataracts were diagnosed according to the Harding diagnostic criteria but failed to be recognized as SCAs on genetic testing. Clinical characteristic analyses of each type of SCAs and radiological examinations were performed.
  
  
  RESULTS
  We found that SCA3/MJD was the most common subtype in Han population in China, and the ratio of the pontine tegmentum and the posterior fossa area was negatively correlated with the number of cytosine-adenine-guanine (CAG) repeats; the disease duration was positively correlated with the International Cooperative Ataxia Rating Scale score; and the CAG repeats number of abnormal alleles was negatively correlated with the age of onset.
  
  
  CONCLUSIONS
  Collectively our study is a systematic research on SCAs in China, which may help for the clinical diagnosis and prenatal screening of this disease, and it may also aid toward better understanding of this disease.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Lan
authors.initials: L
authors.lastname: Li
authors.forename: Yu-Hang
authors.initials: YH
authors.lastname: Gu
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Meng
authors.forename: Kai-Hua
authors.initials: KH
authors.lastname: Zhang
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Le
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
authors.forename: Chun-Bo
authors.initials: CB
authors.lastname: Dong
mesh_terms: D000328:Adult; D042622:DNA Repeat Expansion / Q000235:genetics; D005260:Female; D006801:Humans; D017827:Machado-Joseph Disease / Q000235:genetics / Q000473:pathology; D008297:Male; D009154:Mutation / Q000235:genetics; D020754:Spinocerebellar Ataxias / Q000235:genetics* / Q000473:pathology; D019680:Trinucleotide Repeat Expansion / Q000235:genetics