title: Nanoobjects formed by ionic PAMAM dendrimers: hydrophilic/lipophilic modulation and encapsulation properties.
abstract: In this paper, we present the preparation and properties of some ionic PAMAM derivatives, which combine hydrophilic and lipophilic carboxylic acid chains as counter-ions for all protonable inner and outer amino groups. The amphiphilic nature of the final ionic codendrimers and, hence, their self-assembling features can be modulated by using different ratios between hydrophilic and lipophilic chains. In the bulk, these new materials self-organize into smectic A liquid crystal phases. In water, they self-assemble into different types of nano-objects depending on the molecular composition. The study of the morphology of these nano-structures, their cytotoxicity and their capability to encapsulate a lipophilic anticancer drug are reported herein. Some of these nanoobjects are non-cytotoxic and present good drug trapping ability, which make them interesting nanocarriers for applications in nanotechnology and biomedicine.
authors.affiliation: PharmaMar S.L., 28770 Colmenar Viejo (Madrid), Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fedeli
authors.forename: S
authors.initials: S
authors.lastname: Hernández-Aínsa
authors.forename: A
authors.initials: A
authors.lastname: Lancelot
authors.forename: R
authors.initials: R
authors.lastname: González-Pastor
authors.forename: P
authors.initials: P
authors.lastname: Calvo
authors.forename: T
authors.initials: T
authors.lastname: Sierra
authors.forename: J L
authors.initials: JL
authors.lastname: Serrano
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007477:Ions / Q000737:chemistry; D050866:Liquid Crystals / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry* / Q000627:therapeutic use; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D007477:Ions; C104700:PAMAM Starburst; D014867:Water