title: Adenosine Receptors: The Contributions by John W. Daly.
abstract: John Daly played an important role in defining adenosine receptors as an important target for drug discovery. His systematic work characterized the effects of adenosine analogues on cyclic AMP in the brain that were antagonized by methylxanthines. He also played a decisive role in establishing these receptors asbona fidebiochemical entities and contributed to the discovery of receptor heterogeneity. This brief review will cover some of his important early discoveries in the pharmacology and medicinal chemistry of adenosine receptors.
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
authors.forename: Bertil B
authors.initials: BB
authors.lastname: Fredholm
authors.affiliation: Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA 20892.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson