title: [Correlation of FOXA1 with the malignancy and progression of prostate cancer].
abstract: OBJECTIVE
  To study the relationship of the expression of FOXA1 in the prostate cancer (PCa) tissue with the Gleason score and clinical staging of PCa and with castration-resistant PCa (CRPC).
  
  
  METHODS
  Using the immunohistochemical method, we detected the expressions of FOXA1 and Ki-67 in the pathological sections of 35 cases of PCa and 21 cases of benign prostatic hyperplasia (BPH). Then we analyzed their correlation with the Gleason score and TNM staging of PCa and that with CRPC.
  
  
  RESULTS
  The positive expression of FOXA1 was significantly higher in the PCa than in the BPH tissue (P < 0.001) and was positively correlated with that of Ki-67 (P < 0.001) as well as with the Gleason score (P = 0.027) and clinical staging of PCa (P = 0.002), but showed no correlation with CRPC (P = 0.391).
  
  
  CONCLUSIONS
  The positive expression of FOXA1 is increased in PCa, most significantly in the advanced stage of the tumor.
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Yang-min
authors.initials: YM
authors.lastname: Wang
authors.forename: Ju-long
authors.initials: JL
authors.lastname: Hu
mesh_terms: D018450:Disease Progression; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000378:metabolism*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins