title: Development of nanotoxicology: implications for drug delivery and medical devices.
abstract: Current nanotoxicology research suffers from suboptimal in vitro models, lack of in vitro-in vivo correlations, variability within in vitro protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much in vitro toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.
authors.affiliation: Conway Institute, University College Dublin (UCD), Dublin, Ireland.
authors.forename: Sourav
authors.initials: S
authors.lastname: Bhattacharjee
authors.affiliation: Conway Institute, University College Dublin (UCD), Dublin, Ireland.|School of Veterinary Medicine, University College Dublin (UCD), Dublin, Ireland.
authors.forename: David J
authors.initials: DJ
authors.lastname: Brayden
mesh_terms: D016503:Drug Delivery Systems / Q000009:adverse effects; D006801:Humans; D049329:Nanostructures / Q000009:adverse effects*; D036103:Nanotechnology / Q000379:methods*; D018570:Risk Assessment; D014116:Toxicology / Q000379:methods*
keywords: biomaterials; high-content analysis; lab-on-a-chip; nanotoxicology; predictive toxicology