title: Metallobiology of Tuberculosis.
abstract: Transition metals are essential constituents of all living organisms, playing crucial structural and catalytic parts in many enzymes and transcription factors. However, transition metals can also be toxic when present in excess. Their uptake and efflux rates must therefore be carefully controlled by biological systems. In this chapter, we summarize the current knowledge about uptake and efflux systems in Mycobacterium tuberculosis for mainly three of these metals, namely iron, zinc, and copper. We also propose questions for future research in the field of metallobiology of host-pathogen interactions in tuberculosis.
authors.affiliation: Public Health Research Institute and New Jersey Medical School-Rutgers, the State University of New Jersey, Newark, NJ 07103.
authors.forename: G
authors.initials: G
authors.lastname: Marcela Rodriguez
authors.affiliation: Centre National de la Recherche Scientifique and Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Neyrolles
mesh_terms: D006706:Homeostasis; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D008670:Metals / Q000378:metabolism* / Q000633:toxicity; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D028561:Transition Elements / Q000378:metabolism* / Q000633:toxicity; D014376:Tuberculosis / Q000382:microbiology*
chemical_list: D026901:Membrane Transport Proteins; D008670:Metals; D028561:Transition Elements