title: OS023. Postpartum cardiovascular disease risk factors in women with ahistory of early onset preeclampsia, late onset preeclampsia and pregnancy induced hypertension.
abstract: BACKGROUND
  Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in women. Epidemiological studies have shown an increased risk of a CVD event in women who have had a hypertensive disorder in one of their previous pregnancies. These data also suggest that these increased risks are associated with severity and time of onset of pre-eclampsia. Risk factors for CVD have not yet been compared between women who experienced early versus late and mild versus severe hypertensive disorders of pregnancy.
  
  
  OBJECTIVE
  In this study we compared classic CVD risk factors of postpartum women with previous early-onset preeclampsia (EOPE), late onset pre-eclampsia (LOPE) and pregnancy induced hypertension (PIH).
  
  
  METHODS
  A total of 81 women with previous EOPE (delivery required ⩽34weeks), 76 with LOPE (delivery ⩾36weeks) and 229 with PIH were included along with 79 healthy controls. Statistical analyses were performed using generalized linear models in PASW statistics 17.0, SPSS Inc.
  
  
  RESULTS
  Adjusted means of blood pressure, fasting plasma glucose levels and LDL levels were significantly increased after all hypertensive disorders of pregnancy compared to controls. This increase of CVD risk factors was significantly correlated with severity and time of onset of the disease (Table 1). The prevalence of metabolic syndrome (BMI>30kg/m(2) and ⩾2 of the following; triglycerides ⩾150mg/dl, HDL cholesterol ⩾50mg/dl, systolic blood pressure ⩾130 or diastolic blood pressure ⩾85 and fasting plasma glucose levels ⩾100mg/dl) did not differ between the study groups; women who had PIH had the highest number of components of the metabolic syndrome ().
  
  
  CONCLUSIONS
  These results further establish the predisposition to CVD in women with previous pre-eclampsia or PIH. EOPE is associated with a more pronounced CVD risk factor profile than LOPE or PIH, which may explain the previously described higher CVD event risk.
authors.affiliation: Woman and Baby, University Medical Centre Utrecht, Utrecht, Netherlands.
authors.forename: A Y
authors.initials: AY
authors.lastname: Breimer
authors.affiliation: Woman and Baby, University Medical Centre Utrecht, Utrecht, Netherlands.
authors.forename: W P
authors.initials: WP
authors.lastname: Koster
authors.affiliation: Obstetrics, Leiden University Medical Centre, Leiden, Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Hermes
authors.affiliation: Obstetrics, Free University Medical Centre Amsterdam, Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: de Groot
authors.affiliation: Obstetrics, Academic Medical Centre Amsterdam, Amsterdam, Netherlands.
authors.forename: B W
authors.initials: BW
authors.lastname: Mol
authors.affiliation: Woman and Baby, University Medical Centre Utrecht, Utrecht, Netherlands.
authors.forename: B B
authors.initials: BB
authors.lastname: van Rijn
authors.affiliation: Woman and Baby, University Medical Centre Utrecht, Utrecht, Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Franx