title: A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus.
abstract: An endophytic fungus Paraphaeosphaeria neglecta FT462 isolated from the Hawaiian-plant Lycopodiella cernua (L.) Pic. Serm produced one unusual compound (1, paraphaeosphaeride A) with the 4-pyranone-γ-lactam-1,4-thiazine moiety, along with two new compounds (2 and 3, paraphaeosphaerides B and C, respectively) and the known compound (4). Compounds 1-3 were characterized by NMR and MS spectroscopic analysis. The absolute configuration of the 3-position of compound 1 was determined as S by electronic circular dichroism (ECD) calculations. Compound 3 also showed STAT3 inhibition at 10 μM.
authors.forename: Chun-Shun
authors.initials: CS
authors.lastname: Li
authors.affiliation: ‡National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Ding
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Yang
authors.forename: Gabriella
authors.initials: G
authors.lastname: Miklossy
authors.affiliation: ‡National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Yin
authors.affiliation: ‡National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Division of Pharmacology, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: James
authors.initials: J
authors.lastname: Turkson
authors.affiliation: §Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.
authors.forename: Shugeng
authors.initials: S
authors.lastname: Cao
mesh_terms: D005658:Fungi / Q000737:chemistry* / Q000302:isolation & purification; D006254:Hawaii; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism; D013843:Thiazines / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D007769:Lactams; D011753:Pyrones; D013843:Thiazines; C000602330:paraphaeosphaeride A; C000602331:paraphaeosphaeride B; C000602332:paraphaeosphaeride C