title: PP032. Apolipoprotein profiling in umbilical cord blood of intrauterine growth restricted (IUGR) neonates.
abstract: BACKGROUND
  Fetal umbilical cord HDL concentration is lower in IUGR neonates as compared to gestational age matched controls (CTRL). The causes by now are unknown. A full apolipoprotein analysis of cord blood might help in understanding the changes in lipid metabolism seen in IUGR.
  
  
  OBJECTIVE
  To characterize cord blood apolipoprotein profile of IUGR neonates.
  
  
  METHODS
  Serum of venous umbilical cord blood (15 IUGR vs. 15 CTRL) was analyzed by Multiple Reaction Monitoring (MRM). 15 different known apolipoproteins were profiled. HDL and LDL were measured by colorimetric methods in fetal cord blood and their corresponding mothers.
  
  
  RESULTS
  Fetal HDL (p<0.0001), ApoC1 (p<0.0001), and ApoE (p=0.0001) levels were lower in IUGR as compared to CTRL. Fetal HDL levels were positive correlated to ApoE, ApoC1, and ApoA2 (r=0.79, r=0.74, r=0.56). Fetal LDL levels were positive correlated to ApoB, ApoE, ApoA2, and ApoC3 (r=0.74, r=0.67, r=0.57, r=0.55). Maternal LDL concentrations correlated positive to fetal ApoC1, ApoC2, and LCAT-concentration (r=0.54, r=0.52, r=0.52).
  
  
  CONCLUSIONS
  The results underlines the relevance of ApoE in fetal development. Moreover, we speculate that maternal lipid profile has an impact on fetal lipid metabolisms as evidenced by the association of maternal LDL levels and fetal ApoC1, ApoC2, and LCAT concentrations. This observation requires further confirmation and is worth to be analyzed since it provides a mechanistic link for therapeutic options.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Pecks
authors.forename: Manja
authors.initials: M
authors.lastname: Wölter
authors.forename: Christoph
authors.initials: C
authors.lastname: Borchers
authors.forename: Derek
authors.initials: D
authors.lastname: Smith
authors.forename: Nicolai
authors.initials: N
authors.lastname: Maass
authors.forename: Michael
authors.initials: M
authors.lastname: Glocker
authors.forename: Werner
authors.initials: W
authors.lastname: Rath