title: PP070. Maternal cardiovascular profiling in the first trimester ofpregnancies complicated with gestation induced hypertension or fetal growth restriction.
abstract: BACKGROUND
  Maternal cardiovascular (CV) profiling is useful in the assessment of gestational hypertensive disorders (GHD)(1). The onset of GHD occurs during the first weeks of gestation(2).
  
  
  OBJECTIVE
  To evaluate whether CV profiling can detect first trimester differences between women with uncomplicated pregnancies (UP) and those who will develop GHD or fetal growth restriction (FGR).
  
  
  METHODS
  CV function was evaluated according to standardised protocols in 242 pregnant women around 12 weeks of gestation, using impedance cardiography (ICG) and combined ECG - Doppler ultrasonography. Outcome was evaluated after delivery and categorized as UP (n=218), GHD with or without proteinuria (n=13), and pregnancies complicated with FGR (n=11). Measurements were compared between groups using Mann-Whitney U test for continuous data or Fisher's Exact test for categorical variables.
  
  
  RESULTS
  As compared to UP, women destined to develop GHD showed increased systolic blood pressure, diastolic blood pressure and mean arterial pressure; and decreased ICG aortic velocity - and acceleration index. Pregnancies complicated with FGR showed decreased stroke volume and cardiac output when compared to UP. No differences were found concerning the maternal veins.
  
  
  CONCLUSIONS
  First trimester maternal CV function differs between women with uncomplicated pregnancies and those destined to develop GHD or FGR. Non-invasive CV profiling enables the identification of these differences.
authors.forename: Jolien
authors.initials: J
authors.lastname: Oben
authors.forename: Kathleen
authors.initials: K
authors.lastname: Tomsin
authors.forename: Anneleen
authors.initials: A
authors.lastname: Staelens
authors.forename: Tinne
authors.initials: T
authors.lastname: Mesens
authors.forename: Geert
authors.initials: G
authors.lastname: Molenberghs
authors.forename: Wilfried
authors.initials: W
authors.lastname: Gyselaers