title: Microbead models in glaucoma.
abstract: The sustained and moderate elevation of intraocular pressure, which can be initiated at precise time points, remains the cornerstone of research into the mechanisms of glaucomatous retinal damage. We focus on the use of microbeads to block the outflow of aqueous following anterior chamber injection in a range of animals (mouse, rat and primate). We describe some of the most commonly used parameters and present guidance on injection technique and bead manipulation to facilitate the successful generation of experimental glaucoma.
authors.affiliation: School of Optometry and Vision Sciences, Cardiff University, Maindy Road Cardiff University, CF24 4LU Cardiff, United Kingdom. Electronic address: Morganje3@cardiff.ac.uk.
authors.forename: James E
authors.initials: JE
authors.lastname: Morgan
authors.affiliation: School of Optometry and Vision Sciences, Cardiff University, Maindy Road Cardiff University, CF24 4LU Cardiff, United Kingdom.
authors.forename: James R
authors.initials: JR
authors.lastname: Tribble
mesh_terms: D000818:Animals; D000867:Anterior Chamber; D004195:Disease Models, Animal; D005901:Glaucoma / Q000175:diagnosis / Q000209:etiology*; D007267:Injections; D007429:Intraocular Pressure / Q000502:physiology*; D051379:Mice; D008863:Microspheres; D051381:Rats; D012165:Retinal Ganglion Cells / Q000187:drug effects*
keywords: Animal model; Glaucoma; Microbead; Primate; Rodent