title: Enantioselective construction of a 2,2'-bisindolylmethane scaffold via catalytic asymmetric reactions of 2-indolylmethanols with 3-alkylindoles.
abstract: A chiral phosphoric acid-catalyzed asymmetric reaction of 2-indolylmethanols with 3-alkylindoles has been established, which constructed a biologically important 2,2'-bisindolylmethane scaffold in high yields and good enantioselectivities (up to 98% yield, 94:6 er). This protocol not only provides an efficient method for constructing a 2,2'-bisindolylmethane framework in an enantioselective form, but also promotes the development of 2-indolylmethanol-involved catalytic asymmetric transformations.
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, China. fshi@jsnu.edu.cn.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Gong
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhang
authors.forename: Qiu-Ning
authors.initials: QN
authors.lastname: Zhu
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000737:chemistry*; D008697:Methane / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D012997:Solvents; D008697:Methane; D000432:Methanol