title: Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study.
abstract: OBJECTIVE
  The best time for administering anticoagulation therapy in acute cardioembolic stroke remains unclear. This prospective cohort study of patients with acute stroke and atrial fibrillation, evaluated (1) the risk of recurrent ischemic event and severe bleeding; (2) the risk factors for recurrence and bleeding; and (3) the risks of recurrence and bleeding associated with anticoagulant therapy and its starting time after the acute stroke.
  
  
  METHODS
  The primary outcome of this multicenter study was the composite of stroke, transient ischemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding within 90 days from acute stroke.
  
  
  RESULTS
  Of the 1029 patients enrolled, 123 had 128 events (12.6%): 77 (7.6%) ischemic stroke or transient ischemic attack or systemic embolism, 37 (3.6%) symptomatic cerebral bleeding, and 14 (1.4%) major extracranial bleeding. At 90 days, 50% of the patients were either deceased or disabled (modified Rankin score ≥3), and 10.9% were deceased. High CHA2DS2-VASc score, high National Institutes of Health Stroke Scale, large ischemic lesion and type of anticoagulant were predictive factors for primary study outcome. At adjusted Cox regression analysis, initiating anticoagulants 4 to 14 days from stroke onset was associated with a significant reduction in primary study outcome, compared with initiating treatment before 4 or after 14 days: hazard ratio 0.53 (95% confidence interval 0.30-0.93). About 7% of the patients treated with oral anticoagulants alone had an outcome event compared with 16.8% and 12.3% of the patients treated with low molecular weight heparins alone or followed by oral anticoagulants, respectively (P=0.003).
  
  
  CONCLUSIONS
  Acute stroke in atrial fibrillation patients is associated with high rates of ischemic recurrence and major bleeding at 90 days. This study has observed that high CHA2DS2-VASc score, high National Institutes of Health Stroke Scale, large ischemic lesions, and type of anticoagulant administered each independently led to a greater risk of recurrence and bleedings. Also, data showed that the best time for initiating anticoagulation treatment for secondary stroke prevention is 4 to 14 days from stroke onset. Moreover, patients treated with oral anticoagulants alone had better outcomes compared with patients treated with low molecular weight heparins alone or before oral anticoagulants.
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Maurizio
authors.initials: M
authors.lastname: Paciaroni
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Agnelli
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Nicola
authors.initials: N
authors.lastname: Falocci
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Valeria
authors.initials: V
authors.lastname: Caso
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Cecilia
authors.initials: C
authors.lastname: Becattini
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Simona
authors.initials: S
authors.lastname: Marcheselli
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Christina
authors.initials: C
authors.lastname: Rueckert
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pezzini
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Loris
authors.initials: L
authors.lastname: Poli
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Alessandro
authors.initials: A
authors.lastname: Padovani
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Laszló
authors.initials: L
authors.lastname: Csiba
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Lilla
authors.initials: L
authors.lastname: Szabó
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Sohn
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Tiziana
authors.initials: T
authors.lastname: Tassinari
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Azmil H
authors.initials: AH
authors.lastname: Abdul-Rahim
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Patrik
authors.initials: P
authors.lastname: Michel
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Maria
authors.initials: M
authors.lastname: Cordier
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Peter
authors.initials: P
authors.lastname: Vanacker
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Suzette
authors.initials: S
authors.lastname: Remillard
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Andrea
authors.initials: A
authors.lastname: Alberti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Michele
authors.initials: M
authors.lastname: Venti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Umberto
authors.initials: U
authors.lastname: Scoditti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Licia
authors.initials: L
authors.lastname: Denti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Giovanni
authors.initials: G
authors.lastname: Orlandi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Gino
authors.initials: G
authors.lastname: Gialdini
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Paolo
authors.initials: P
authors.lastname: Bovi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Monica
authors.initials: M
authors.lastname: Carletti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Alberto
authors.initials: A
authors.lastname: Rigatelli
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Jukka
authors.initials: J
authors.lastname: Putaala
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Turgut
authors.initials: T
authors.lastname: Tatlisumak
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Luca
authors.initials: L
authors.lastname: Masotti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Gianni
authors.initials: G
authors.lastname: Lorenzini
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Rossana
authors.initials: R
authors.lastname: Tassi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Francesca
authors.initials: F
authors.lastname: Guideri
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Martini
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Georgios
authors.initials: G
authors.lastname: Tsivgoulis
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Kostantinos
authors.initials: K
authors.lastname: Vadikolias
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Chrissoula
authors.initials: C
authors.lastname: Liantinioti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Francesco
authors.initials: F
authors.lastname: Corea
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Massimo
authors.initials: M
authors.lastname: Del Sette
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Walter
authors.initials: W
authors.lastname: Ageno
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: De Lodovici
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bono
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Antonio
authors.initials: A
authors.lastname: Baldi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Sebastiano
authors.initials: S
authors.lastname: D'Anna
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Simona
authors.initials: S
authors.lastname: Sacco
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Antonio
authors.initials: A
authors.lastname: Carolei
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Cindy
authors.initials: C
authors.lastname: Tiseo
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Monica
authors.initials: M
authors.lastname: Acciarresi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Cataldo
authors.initials: C
authors.lastname: D'Amore
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Davide
authors.initials: D
authors.lastname: Imberti
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Dorjan
authors.initials: D
authors.lastname: Zabzuni
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Boris
authors.initials: B
authors.lastname: Doronin
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Vera
authors.initials: V
authors.lastname: Volodina
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Domenico
authors.initials: D
authors.lastname: Consoli
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Franco
authors.initials: F
authors.lastname: Galati
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Alessio
authors.initials: A
authors.lastname: Pieroni
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Danilo
authors.initials: D
authors.lastname: Toni
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Serena
authors.initials: S
authors.lastname: Monaco
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Mario Maimone
authors.initials: MM
authors.lastname: Baronello
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Kristian
authors.initials: K
authors.lastname: Barlinn
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Lars-Peder
authors.initials: LP
authors.lastname: Pallesen
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Jessica
authors.initials: J
authors.lastname: Kepplinger
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Ulf
authors.initials: U
authors.lastname: Bodechtel
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Johannes
authors.initials: J
authors.lastname: Gerber
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Dirk
authors.initials: D
authors.lastname: Deleu
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Gayane
authors.initials: G
authors.lastname: Melikyan
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Faisal
authors.initials: F
authors.lastname: Ibrahim
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Mosconi
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Valentina
authors.initials: V
authors.lastname: Bubba
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Ilenia
authors.initials: I
authors.lastname: Silvestri
authors.affiliation: From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech 
authors.forename: Kennedy R
authors.initials: KR
authors.lastname: Lees
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants
keywords: anticoagulant therapy; atrial fibrillation; hemorrhagic stroke; ischemic stroke; secondary prevention