title: Multifunctional carbon nanomaterial hybrids for magnetic manipulation and targeting.
abstract: Nanosized materials and multifunctional nanoscale platforms have attracted in the last years considerable interest in a variety of different fields including biomedicine. Carbon nanotubes and graphene are some of the most widely used carbon nanomaterials (CNMs) due to their unique morphology and structure and their characteristic physicochemical properties. Their high surface area allows efficient drug loading and bioconjugation and makes them the ideal platforms for decoration with magnetic nanoparticles (MNPs). In the biomedical area, MNPs are of particular importance due to their broad range of potential applications in drug delivery, non-invasive tumor imaging and early detection based on their optical and magnetic properties. The remarkable characteristics of CNMs and MNPs can be combined leading to CNM/MNP hybrids which offer numerous promising, desirable and strikingly advantageous properties for improved performance in comparison to the use of either material alone. In this minireview, we attempt to comprehensively report the most recent advances made with CNMs conjugated to different types of MNPs for magnetic targeting, magnetic manipulation, capture and separation of cells towards development of magnetic carbon-based devices.
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France.
authors.forename: Ngoc Do
authors.initials: ND
authors.lastname: Quyen Chau
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France.
authors.forename: Cécilia
authors.initials: C
authors.lastname: Ménard-Moyon
authors.affiliation: Nanomedicine Laboratory, Faculty of Medical & Human Sciences and National Graphene Institute, University of Manchester, AV Hill Building, Manchester M13 9PT, United Kingdom.
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
authors.affiliation: CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France. Electronic address: a.bianco@ibmc-cnrs.unistra.fr.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
mesh_terms: D002469:Cell Separation / Q000379:methods*; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D008846:Micromanipulation / Q000379:methods*; D058726:Nanoconjugates / Q000737:chemistry* / Q000528:radiation effects; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D037742:Nanotubes, Carbon
keywords: Cancer; Carbon nanotubes; Diagnosis; Graphene; Hybrids; Hyperthermia; Imaging; Magnetic properties; Multifunctionalization; Nanoparticles; Therapy