title: [Cutaneous granulomatous reactions at botulinum neurotoxin A injection sites: First manifestation of systemic sarcoidosis].
abstract: METHODS
  We report a case of granulomatous skin reaction after injection of an unknown botulinum neurotoxin (BoNT) A preparation. Four years after occurrence of skin lesions, systemic sarcoidosis became manifest.
  
  
  CONCLUSIONS
  In addition to injection trauma, the BoNT A preparation may have acted as an immunogenic stimulus leading to cutaneous manifestation of sarcoidosis.
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland. breuer@dermatologikum.de.
authors.forename: V G
authors.initials: VG
authors.lastname: Herbert
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: N
authors.initials: N
authors.lastname: Blödorn-Schlicht
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Böer-Auer
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Getova
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: V
authors.initials: V
authors.lastname: Steinkraus
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Reich
authors.affiliation: Dermatologikum Hamburg, Stephansplatz 5, 20354, Hamburg, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Breuer
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000009:adverse effects; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects; D008875:Middle Aged; D012507:Sarcoidosis / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D012871:Skin Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy; D063189:Symptom Assessment / Q000379:methods; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A
keywords: Foreign body granuloma; Foreign body reaction; Granuloma; Immunogenetic phenomena; Injection