title: L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors.
abstract: L-type amino acid transporter-1 (LAT1) is expressed in many cancers. We examined LAT1 and CD98 expression immunohistochemically in surgically resected specimens of various bone and soft tissue tumors. Out of 226 cases, 79 (35%) were LAT1(+) and 95 (42%) were CD98(+) . In bone tumors, LAT1 was highly expressed in osteoblastoma (89%), chondrosarcoma (50%), and osteosarcoma (60%); in soft tissue tumors, LAT1 was highly expressed in rhabdomyosarcoma (80%), synovial sarcoma (63%), Ewing's sarcoma (60%), epithelioid sarcoma (100%) and angiosarcoma (100%). In malignant soft tissue tumors, LAT1 expression was associated with higher histological grade. High CD98 expression was seen in many bone tumors of intermediate and high malignancy. Among soft tissue tumors, CD98 was expressed in tendon sheath giant cell tumor and malignant peripheral nerve sheath tumor (57%), Ewing's sarcoma (50%) and undifferentiated sarcoma (64%). Some of the malignant soft tissue tumors expressed both LAT1 and CD98. This study showed that LAT1 and CD98 was expressed in many malignant and intermediate bone tumors, and some malignant soft tissue tumors.
authors.affiliation: Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.|Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Koshi
authors.affiliation: Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sano
authors.affiliation: Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Handa
authors.affiliation: Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yanagawa
authors.affiliation: Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Saitou
authors.affiliation: Department of Pharmacology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Shushi
authors.initials: S
authors.lastname: Nagamori
authors.affiliation: Department of Pharmacology, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Kanai
authors.affiliation: Department of Orthopedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Takagishi
authors.affiliation: Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
authors.forename: Tetsunari
authors.initials: T
authors.lastname: Oyama
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D027261:Fusion Regulatory Protein-1 / Q000378:metabolism; D006801:Humans; D027283:Large Neutral Amino Acid-Transporter 1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology; D013584:Sarcoma, Synovial / Q000378:metabolism* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D027261:Fusion Regulatory Protein-1; D027283:Large Neutral Amino Acid-Transporter 1
keywords: CD98; L-type amino acid transporter-1; bone tumors; immunohistochemistry; soft tissue tumors