title: Investigation of TG gene variants and their effects on growth, carcass composition, and meat quality traits in Chinese steers.
abstract: Thyroid hormones play an important role in regulating metabolism and can affect metabolism-related traits such as fat deposition. The thyroglobulin (TG) gene produces the precursor of thyroid hormones and has been proposed as a candidate gene for a quantitative trait locus with an effect on fat deposition. In this study, we identified 4 novel single nucleotide polymorphisms (SNPs) in the 5' flanking region of the TG gene using a DNA sequencing method. The SNP marker association analysis indicated that the T1355C SNPs were significantly associated with meat percentage (P < 0.05). A significant association between the G1356A polymorphism and live weight and loin muscle area was also detected (P < 0.05). However, no significant association was found between 4 SNPs and the other growth, carcass composition, and meat quality traits including intramuscular fat. The results of this study suggest that TG gene-specific SNPs may be a useful marker for growth traits in marker-assisted selection programs in beef cattle.
authors.affiliation: Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Zhang
authors.affiliation: College of Animal Science, Fujian Agricultural and Forestry University, Fuzhou, Fujian, China.
authors.forename: Q F
authors.initials: QF
authors.lastname: Gan
authors.affiliation: Institute of Tropical Crop Genetic Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou, Hainan, China.
authors.forename: G Y
authors.initials: GY
authors.lastname: Hou
authors.affiliation: Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Gao
authors.affiliation: Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China JL1@iascaas.net.cn.
authors.forename: J Y
authors.initials: JY
authors.lastname: Li
authors.affiliation: Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Xu
mesh_terms: D000818:Animals; D001823:Body Composition / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D002417:Cattle; D002681:China; D056726:Genetic Association Studies; D005838:Genotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D000069466:Red Meat; D013954:Thyroglobulin / Q000235:genetics*
chemical_list: D013954:Thyroglobulin