title: Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma.
abstract: Although the expression of tumor necrosis factor receptors (TNFRs) has been associated with clinicopathologic features of some other cancers, their roles in hypopharyngeal squamous cell carcinoma (HPSCC) have not been documented. Forty-five HPSCC specimens were analyzed for the expression of TNFR1 and TNFR2 and its relationship with clinicopathologic factors. Interaction between the two receptors and its effects on TNF-α was investigated by neutralizing TNFR1 and upregulation of TNFR2. The results indicated that, in HPSCC specimens, the expression of TNFR1 but not TNFR2 is associated with clinical staging, T stage, cervical lymph node metastasis, and histologic grade in HPSCC. In Fadu cells, when conjugating with its receptors, TNF-α mediates proliferation effects, and neutralizing TNFR1 and/or upregulating TNFR2 evokes proliferation-inhibiting and apoptosis-inducing effects and potentiates cisplatin (DDP)-induced growth inhibition and apoptosis induction. In conclusion, interaction of TNFR1 with TNFR2 determines the biological characters of HPSCC, and TNFR1 may dominate this process. Moreover, interaction between the two receptors plays important roles in determining the fates of HPSCC cells and thus may serve as a therapeutic target for developing new therapeutic strategies for HPSCC.
authors.affiliation: Postgraduate School, Hebei Medical University, Shijiazhuang, Hebei, China.|Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China.
authors.forename: Xiuru
authors.initials: X
authors.lastname: Ma
authors.affiliation: Postgraduate School, Hebei Medical University, Shijiazhuang, Hebei, China. xmlmoo@yeah.net.|Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China. xmlmoo@yeah.net.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China.
authors.forename: Xiuying
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Bethune International Peace Hospital, Zhongshan West Street 398, Shijiazhuang, 050081, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000096:biosynthesis* / Q000235:genetics; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha
keywords: Cell proliferation; Clinicopathologic factor; Hypopharyngeal squamous cell carcinoma; Receptor interaction; Tumor necrosis factor receptor (TNFR)