title: Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3: protocol for a longitudinal study.
abstract: BACKGROUND
  Patients with cardiovascular disease are living longer and are more frequently accessing healthcare resources. The Evaluation of the Methods and Management of Acute Coronary Events (EMMACE)-3 national study is designed to improve understanding of the effect of quality of care on health-related outcomes for patients hospitalised with acute coronary syndrome (ACS).
  
  
  METHODS
  EMMACE-3 is a longitudinal study of 5556 patients hospitalised with an ACS in England. The study collects repeated measures of health-related quality of life, information about medications and patient adherence profiles, a survey of hospital facilities, and morbidity and mortality data from linkages to multiple electronic health records. Together with EMMACE-3X and EMMACE-4, EMMACE-3 will assimilate detailed information for about 13 000 patients across more than 60 hospitals in England.
  
  
  BACKGROUND
  EMMACE-3 was given a favourable ethical opinion by Leeds (West) Research Ethics committee (REC reference: 10/H131374). On successful application, study data will be shared with academic collaborators. The findings from EMMACE-3 will be disseminated through peer-reviewed publications, at scientific conferences, the media, and through patient and public involvement.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier: NCT01808027. Information about the study is also available at EMMACE.org.
authors.affiliation: Division of Epidemiology and Biostatistics, University of Leeds, Leeds, UK.
authors.forename: O A
authors.initials: OA
authors.lastname: Alabas
authors.affiliation: Leeds Institute of Health Science, University of Leeds, Leeds, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: West
authors.affiliation: Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Gillott
authors.affiliation: Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: R
authors.initials: R
authors.lastname: Khatib
authors.affiliation: Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Hall
authors.affiliation: Division of Epidemiology and Biostatistics, University of Leeds, Leeds, UK York Teaching Hospital NHS Foundation Trust, York, UK.
authors.forename: C P
authors.initials: CP
authors.lastname: Gale
mesh_terms: D054058:Acute Coronary Syndrome / Q000401:mortality / Q000628:therapy*; D000368:Aged; D019468:Disease Management; D004739:England / Q000453:epidemiology; D005260:Female; D006304:Health Status; D006760:Hospitalization; D006761:Hospitals / Q000592:standards*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy*; D011787:Quality of Health Care; D011788:Quality of Life; D012107:Research Design; D016896:Treatment Outcome