title: The Beneficial Effects of the DPP-4 Inhibitor Alogliptin on Hemoglobin A1c and Serum Lipids in Japanese Patients with Type 2 Diabetes.
abstract: It has been reported that dipeptidyl peptidase-4 (DPP-4) inhibitors improve hemoglobin A1c (HbA1c) levels in diabetic patients and may also improve the serum lipids. However, few studies have examined relationship between the effects of the DPP-4 inhibitor and the pretreatment HbA1c levels in diabetic patients. Furthermore, it has been reported that prolonged treatment with DPP-4 inhibitors may make glycemic control difficult in some patients. In the present study, we investigated (1) the effect of the DPP-4 inhibitor alogliptin on HbA1c, blood glucose (BG), and serum lipid in Japanese patients with type 2 diabetes, (2) the relationship between the HbA1c levels at baseline and the effects of alogliptin, and (3) the effects of switching of the DPP-4 inhibitor to alogliptin after 12 months' administration of sitagliptin on glycemic control and serum lipids. After 6-months' treatment with alogliptin, we found reductions of HbA1c, BG, and serum total cholesterol, and LDL cholesterol levels. Pretreatment level of HbA1c was well correlated with the degree of reduction of both HbA1c and BG levels after the treatment. Also, alogliptin kept levels of HbA1c and BG reduced by sitagliptin for 12 months, and relapsing of these levels and serum lipids were not observed. This study revealed that alogliptin improved HbA1c, BG, and serum lipid profiles in type 2 diabetic patients, and the effect of alogliptin on HbA1c and BG levels was correlated with HbA1c level at pretreatment. Furthermore, long-term treatment with alogliptin did not cause relapsing of glycemic control and serum lipids.
authors.affiliation: Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kusunoki
authors.affiliation: Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Sato
authors.affiliation: Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Oshida
authors.affiliation: General Medical Education Center of Teikyo University, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tsutsui
authors.affiliation: Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Natsume
authors.affiliation: Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsutsumi
authors.affiliation: Vascular Center, Sanno Medical Center, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyata
mesh_terms: D044466:Asian People; D001786:Blood Glucose / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism*; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D000068900:Sitagliptin Phosphate / Q000627:therapeutic use; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; D018819:Dipeptidyl Peptidase 4; D054873:Dipeptidyl-Peptidase IV Inhibitors; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008055:Lipids; D010880:Piperidines; D000068900:Sitagliptin Phosphate; D014498:Uracil; C517652:hemoglobin A1c protein, human; C042807:DPP4 protein, human; C520853:alogliptin