title: Different immune cells mediate mechanical pain hypersensitivity in male and female mice.
abstract: A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.
authors.affiliation: 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Sorge
authors.affiliation: 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [3] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [4] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada.
authors.forename: Josiane C S
authors.initials: JC
authors.lastname: Mapplebeck
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Sarah
authors.initials: S
authors.lastname: Rosen
authors.affiliation: 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada.
authors.forename: Simon
authors.initials: S
authors.lastname: Beggs
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Taves
authors.affiliation: 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Alexander
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Loren J
authors.initials: LJ
authors.lastname: Martin
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Jean-Sebastien
authors.initials: JS
authors.lastname: Austin
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Susana G
authors.initials: SG
authors.lastname: Sotocinal
authors.affiliation: Department of Psychology, McGill University, Montreal, Quebec, Canada.
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
authors.forename: Mu
authors.initials: M
authors.lastname: Yang
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
authors.forename: Xiang Qun
authors.initials: XQ
authors.lastname: Shi
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Pillon
authors.affiliation: Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Bilan
authors.affiliation: Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: YuShan
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Amira
authors.initials: A
authors.lastname: Klip
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: Ru-Rong
authors.initials: RR
authors.lastname: Ji
authors.affiliation: 1] Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. [2] Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 1] Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada. [3] University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada.
authors.forename: Michael W
authors.identifier: 0000000168976585
authors.initials: MW
authors.lastname: Salter
authors.affiliation: 1] Department of Psychology, McGill University, Montreal, Quebec, Canada. [2] Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Mogil
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D017628:Microglia / Q000378:metabolism*; D009437:Neuralgia / Q000276:immunology*; D012727:Sex Characteristics; D012737:Sex Factors; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism*