title: Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders.
abstract: OBJECTIVE
  A broad range of hepatocellular nodules has been reported in hepatic vascular disorders. It is not clear whether hepatocellular adenoma (HCA) in this context share the same characteristics as conventional HCA. The aim of this study was to carry out a retrospective multicenter survey of hepatocellular nodules associated with hepatic vascular disorders.
  
  
  METHODS
  Forty-five cases were reviewed, including 32 Budd-Chiari syndrome (BCS). Benign nodules were subtyped using the HCA immunohistochemical panel.
  
  
  RESULTS
  Nodules with a HCA morphology were observed in 11 cases. Six originated in BCS: two were liver fatty acid binding protein (LFABP) negative (one with malignant transformation); two expressed glutamine synthetase (GS) and nuclear b-catenin, two expressed C reactive protein (CRP). Among three cases with portal vein agenesis, one nodule was LFABP negative, two expressed GS and nuclear b-catenin, both with malignant transformation. In a Fallot tetralogy case, there were multiple LFABP negative nodules with borderline features and in a hepatoportal sclerosis case, the nodule looked like an inflammatory HCA. Two additional cases had nodules expressing CRP, without typical characteristics of inflammatory HCA.
  
  
  CONCLUSIONS
  HCA of different immunohistochemical phenotype can develop in hepatic vascular disorders; they may have a different behavior compared to conventional HCA and be more at risk of malignant transformation.
authors.affiliation: Service d'Anatomie pathologique, Cliniques universitaires Saint-Luc, Avenue Hippocrate, 10, B-1200 Brussels, Belgium.
authors.forename: Christine
authors.initials: C
authors.lastname: Sempoux
authors.affiliation: Inserm UMR 1149, Université Paris Diderot, Department of Pathology, Beaujon Hospital, 92110 Clichy, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Paradis
authors.affiliation: Translational Cell & Tissue Research Unit, Department of Imaging & Pathology, K.U. Leuven, Minderbroedersstraat 12, Leuven 3000, Belgium.
authors.forename: Mina
authors.initials: M
authors.lastname: Komuta
authors.affiliation: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, Singapore 119074, Singapore.
authors.forename: Aileen
authors.initials: A
authors.lastname: Wee
authors.affiliation: Department of Pathology, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Henri Mondor, 94000 Créteil, France; INSERM, U955, Institut Mondor de Recherche Biomédicale, 94010 Créteil, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Calderaro
authors.affiliation: Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Balabaud
authors.affiliation: Institute of Liver Studies, King's College Hospital, London, UK.
authors.forename: Alberto
authors.initials: A
authors.lastname: Quaglia
authors.affiliation: Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France; Department of Pathology, Pellegrin Hospital, Centre Hospitalier Universitaire Bordeaux, F-33076, France. Electronic address: paulette.bioulac-sage@u-bordeaux.fr.
authors.forename: Paulette
authors.initials: P
authors.lastname: Bioulac-Sage
mesh_terms: D018248:Adenoma, Liver Cell / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D006502:Budd-Chiari Syndrome / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002097:C-Reactive Protein / Q000096:biosynthesis; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D050556:Fatty Acid-Binding Proteins / Q000096:biosynthesis; D005974:Glutamate-Ammonia Ligase / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D050556:Fatty Acid-Binding Proteins; D002097:C-Reactive Protein; D005974:Glutamate-Ammonia Ligase
keywords: Budd-Chiari syndrome; Hepatic vascular disorders; Hepatocellular adenoma; Hepatocellular carcinoma; Immunohistochemical phenotype