title: Co-Existence of Multicentric Castleman's Disease and Kaposi's Sarcoma.
abstract: Castleman's disease (CD) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. Multicentric Castleman's disease (MCD) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. Human herpesvirus 8 (HHV-8) infection is present in nearly 100% MCD associated with HIV-1 infection, but in about 50% of cases of HIV negative. Herein, we report a 77-year-old man with systemic involvement and skin lesions on the anterior aspect of both legs in the previous site of saphenous vein angioplasty. Co-existence of MCD with Kaposi's sarcoma (KS) led us to present this rare case.
authors.affiliation: Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Yaghoobi
authors.affiliation: Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Nader
authors.initials: N
authors.lastname: Pazyar
authors.affiliation: Department of Dermatology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Sadigheh
authors.initials: S
authors.lastname: Tavakoli
keywords: Giant lymph node hyperplasia; Kaposi; herpes virus 8; human; human immunodeficiency virus; multi-centric Castleman's disease; sarcoma