title: Importance of lipid accumulation product index as a marker of CVD risk in PCOS women.
abstract: BACKGROUND
  The polycystic ovary syndrome (PCOS) is considered the most common endocrine disease during the woman's reproductive life, with prevalence ranging from 5 to 10% of women of reproductive age. There is a paucity of studies regarding the use of the lipid accumulation product (LAP) as a risk marker for the development of cardiovascular disease (CVD).
  
  
  METHODS
  A cross-sectional study was conducted on 78 women aged 18 to 42 years seen at University Hospital of Maranhão, with a diagnosis of polycystic ovary syndrome according to the Rotterdam criteria. The following variables of interest were recorded on a protocol form: sociodemographic and behavioral data, body mass index, waist circumference, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, high-density lipoprotein cholesterol, and systolic and diastolic blood pressure.
  
  
  RESULTS
  Logistic regression showed that, except for HDL, all cardiovascular risk markers presented a higher chance of being altered when the lipid accumulation product was above the cut off value of 37.9 cm.mmol/L.
  
  
  CONCLUSIONS
  The lipid accumulation product seems to be sufficient to indicate a risk of cardiovascular diseases in women with polycystic ovary syndrome.
authors.affiliation: Universidade Federal do Maranhão, São Luís, Maranhão, Brazil. joelmaximenes@yahoo.com.br.|, Rua Boa Esperança, Cond. Bosque dos Pinheiros Qd. 03, C. 02 - Bairro: Turú, São Luís, Maranhão, Brazil. joelmaximenes@yahoo.com.br.
authors.forename: Joelma Ximenes Prado Teixeira
authors.initials: JX
authors.lastname: Nascimento
authors.affiliation: Universidade Federal do Maranhão, São Luís, Maranhão, Brazil. bethaniachein@ufma.br.|, Rua Boa Esperança, Cond. Bosque dos Pinheiros Qd. 03, C. 02 - Bairro: Turú, São Luís, Maranhão, Brazil. bethaniachein@ufma.br.
authors.forename: Maria Bethânia da Costa
authors.initials: MB
authors.lastname: Chein
authors.affiliation: Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.
authors.forename: Rosângela Maria Lopes
authors.initials: RM
authors.lastname: de Sousa
authors.affiliation: Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.
authors.forename: Alexsandro dos Santos
authors.initials: Ados S
authors.lastname: Ferreira
authors.affiliation: USP/Ribeirão Preto, São Paulo, São Paulo, Brazil.
authors.forename: Paula Andrea
authors.initials: PA
authors.lastname: Navarro
authors.affiliation: Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.
authors.forename: Luciane Maria Oliveira
authors.initials: LM
authors.lastname: Brito
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000150:complications* / Q000378:metabolism*; D003710:Demography; D005260:Female; D006801:Humans; D064237:Lipid Accumulation Product; D016015:Logistic Models; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism*; D012372:ROC Curve; D012307:Risk Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers