title: Prognostic value of late gadolinium enhancement in dilated cardiomyopathy patients: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association between late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) and major adverse events in dilated cardiomyopathy (DCM) patients.
  
  
  METHODS
  Databases, including PubMed, Ovid, and EMBASE, were searched for studies evaluating LGE at CMR in DCM patient prognostication. Clinical outcomes were analysed using fixed-effects models or, in cases of significant heterogeneity, random-effects models.
  
  
  RESULTS
  In the meta-analysis of 13 studies on 1675 DCM patients with a mean follow-up of 3 years, LGE is associated with all-cause mortality (pooled odds ratio, 3.43 [95% confidence interval, 2.26-5.22], p<0.00001), cardiac death/transplantation (3.65 [1.80-7.40], p=0.0003), hospitalisation for heart failure (2.87 [1.53-5.39], p=0.001), major arrhythmia events (sudden cardiac death, sustained ventricular tachycardia or fibrillation, appropriate implantable cardioverter-defibrillator (ICD) discharge/pacing, and syncope: 4.24 [2.95-6.08], p<0.00001), and sudden cardiac death (3.33 [1.80-6.17], p=0.0001).
  
  
  CONCLUSIONS
  LGE in DCM patients appears to be associated with mortality and major cardiac events, underscoring its potential as an independent index for risk stratification and treatment guidance.
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Duan
authors.affiliation: Chinese Evidence-based Medicine/Cochrane Centre, Department of Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
authors.forename: J
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Division of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China. Electronic address: chenyucheng2003@126.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D011379:Prognosis; D018570:Risk Assessment
chemical_list: D003287:Contrast Media; D005682:Gadolinium