title: Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques.
abstract: This comparative study was conducted to assess background physiologic and pharmacologic parameters of cynomolgus macaques (Macaca fascicularis) from Cambodia, from a mixed Asian source (Cambodia, Vietnam and Indonesia), and from Mauritius. This evaluation provides a comprehensive assessment of several of these parameters in a single study. Ten male and 10 female captive-bred, age-matched macaques from each source were evaluated. Criteria for evaluation included weight gain, assessment of drug metabolizing enzyme activity, metabolomic analysis, immunologic assessments (lymphocyte subsets, TDAR, and serum Ig isotyping), clinical pathology evaluations, physical (respiratory, neurologic, cardiovascular, and ophthalmologic) examinations, pathogen screening, organ weights, and gross and microscopic pathology analyses. The results of this evaluation indicate that, compared to macaques of Asian origin, macaques from Mauritius had the lowest incidence and/or severity of spontaneous pathologic findings in several organs and tissues (lymphoid organs, stomach, kidney, urothelium, heart, arteries and lung) and better testicular maturity at a given age with minimal variability in organ weights. Although slight differences were observed in other parameters, none were considered detrimental to the use of macaques of Asian or Mauritius origin in pharmaceutical candidate safety studies with the use of a consistent source, concomitant controls, and appropriate background knowledge and screening.
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick, NJ, USA. Electronic address: john.kozlosky@bms.com.
authors.forename: John C
authors.initials: JC
authors.lastname: Kozlosky
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick, NJ, USA.
authors.forename: Jagannatha
authors.initials: J
authors.lastname: Mysore
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, Mount Vernon, IN, USA.
authors.forename: Shawn P
authors.initials: SP
authors.lastname: Clark
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick, NJ, USA.
authors.forename: Holly N
authors.initials: HN
authors.lastname: Burr
authors.affiliation: Genentech, Inc., Safety Assessment Development Sciences, South San Francisco, CA, USA.
authors.forename: Jinze
authors.initials: J
authors.lastname: Li
authors.affiliation: Bristol-Myers Squibb, Discovery Toxicology, Research and Development, Princeton, NJ, USA.
authors.forename: Nelly
authors.initials: N
authors.lastname: Aranibar
authors.affiliation: Bristol-Myers Squibb, Metabolism and Pharmacokinetics, Research and Development, Princeton, NJ, USA.
authors.forename: Ragini
authors.initials: R
authors.lastname: Vuppugalla
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, Princeton, NJ, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: West
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, New Brunswick, NJ, USA.
authors.forename: Raja S
authors.initials: RS
authors.lastname: Mangipudy
authors.affiliation: Bristol-Myers Squibb, Drug Safety Evaluation, Research and Development, Princeton, NJ, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Graziano
mesh_terms: D000818:Animals; D044466:Asian People; D005260:Female; D006801:Humans; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008436:Mauritius; D009929:Organ Size / Q000502:physiology*
keywords: Asian macaque; Background parameters; Cynomolgus macaque; Mauritius macaque; Pharmacologic comparison; Physiologic comparison