title: Nano-enabled drug delivery systems for brain cancer and Alzheimer's disease: research patterns and opportunities.
abstract: "Tech mining" applies bibliometric and text analytic methods to scientific literature of a target field. In this study, we compare the evolution of nano-enabled drug delivery (NEDD) systems for two different applications - viz., brain cancer (BC) and Alzheimer's disease (AD) - using this approach. In this process, we derive research intelligence from papers indexed in MEDLINE. Review by domain specialists helps understand the macro-level disease problems and pathologies to identify commonalities and differences between BC and AD. Results provide a fresh perspective on the developmental pathways for NEDD approaches that have been used in the treatment of BC and AD. Results also point toward finding future solutions to drug delivery issues that are critical to medical practitioners and pharmaceutical scientists addressing the brain.
  
  
  BACKGROUND
  Drug delivery to brain cells has been very challenging due to the presence of the blood-brain barrier (BBB). Suitable and effective nano-enabled drug delivery (NEDD) system is urgently needed. In this study, the authors utilized "tech-mining" tools to describe and compare various choices of delivery system available for the diagnosis, as well as treatment, of brain cancer and Alzheimer's disease.
authors.affiliation: School of Management and Economics, Beijing Institute of Technology, Beijing, China. Electronic address: majing881003@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: School of Public Policy and Technology Policy & Assessment Center, Georgia Institute of Technology, Atlanta, GA, USA; Search Technology, Inc., Atlanta, GA, USA. Electronic address: alan.porter@isye.gatech.edu.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Porter
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Chemistry, Shree Dhanvantary Pharmacy College, Surat, India. Electronic address: aminabhavit@gmail.com.
authors.forename: Tejraj M
authors.initials: TM
authors.lastname: Aminabhavi
authors.affiliation: School of Management and Economics, Beijing Institute of Technology, Beijing, China. Electronic address: zhudh111@bit.edu.cn.
authors.forename: Donghua
authors.initials: D
authors.lastname: Zhu
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D001812:Blood-Brain Barrier / Q000737:chemistry; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016503:Drug Delivery Systems; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D004364:Pharmaceutical Preparations
chemical_list: D004364:Pharmaceutical Preparations
keywords: Alzheimer’s disease; Brain cancer; Nano-enabled drug delivery (NEDD); Tech mining; Technology opportunities analysis