title: Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis.
abstract: Tumor growth creates a hypoxic microenvironment, which promotes angiogenesis and aggressive tumor growth and invasion. HIF1α is a central molecule involved in mediating these effects of hypoxia. In colorectal cancer (CRC), hypoxia stabilizes the transcription factor HIF1α, leading to the expression of genes that are involved in tumor vascularization, metastasis/migration, cell survival and chemo-resistance. Therefore, HIF1α is a rational target for the development of new therapeutics for CRC. This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, and progression as well as the strategies to target HIF1α stabilization.
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
authors.forename: Ganji Purnachandra
authors.initials: GP
authors.lastname: Nagaraju
authors.affiliation: Department of Biotechnology, Krishna University, Machilipatnam, AP-521001, India.
authors.forename: Pallaval Veera
authors.initials: PV
authors.lastname: Bramhachari
authors.affiliation: Department of Biotechnology, Krishna University, Machilipatnam, AP-521001, India.
authors.forename: Godi
authors.initials: G
authors.lastname: Raghu
authors.affiliation: Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. Electronic address: belraye@emory.edu.
authors.forename: Bassel F
authors.initials: BF
authors.lastname: El-Rayes
mesh_terms: D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology; D009362:Neoplasm Metastasis; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000502:physiology; D055550:Protein Stability; D017382:Reactive Oxygen Species / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
chemical_list: C495270:CTNNB1 protein, human; C527276:CXCR4 protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D035683:MicroRNAs; C539821:NR4A1 protein, human; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D017382:Reactive Oxygen Species; D019718:Receptors, CXCR4; D051176:beta Catenin
keywords: Colorectal cancer; HIF1α; Metastasis; Stemness; Tumor resistance