title: Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury.
abstract: Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide, yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied. In this study, Apelin-13 (0.1 μg/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats. TTC, TUNEL, and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group, infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group. Additionally, Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity. Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.
authors.affiliation: Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Xiao-Ge
authors.initials: XG
authors.lastname: Yan
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Cheng
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
authors.forename: Liang-Cai
authors.initials: LC
authors.lastname: Ding
authors.affiliation: Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Liu
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining, Shandong Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Bai
keywords: Apelin-13; Bcl-2; NSFC grants; brain injury; caspase-3; cerebral ischemia/reperfusion injury; lateral intracerebroventricular injection; nerve apoptosis; nerve regeneration; neural regeneration; neuroprotection