title: MicroRNA-205 regulates ubiquitin specific peptidase 7 protein expression in hepatocellular carcinoma cells.
abstract: Ubiquitin specific peptidase 7 (UPS7) has a critical role in the development and progression of cancer, at least in part, through its regulation of p53 protein stability. However, its molecular determinants remain to be elucidated. In the present study, it was identified that microRNA‑205 (miR‑205) may negatively regulate UPS7 protein levels through targeting its 3'‑untranslated region in hepatocellular carcinoma (HCC) cells. As a result, miR‑205 mimics inhibited USP7 protein levels while antisense miR‑205 enhanced USP7 protein levels, thereby modulating the p53 signaling pathway and cell proliferation levels. In conclusion, the data presents a novel molecule for the dysregulated expression of USP7 in HCC, which may assist in elucidating mechanisms underlying the tumorigenesis of HCC.
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Qian
authors.affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wang
mesh_terms: D020413:3' Untranslated Regions; D001665:Binding Sites; D006528:Carcinoma, Hepatocellular; D049109:Cell Proliferation; D015536:Down-Regulation; D004794:Enzyme Repression; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference; D043222:Ubiquitin Thiolesterase / Q000235:genetics* / Q000378:metabolism; D000076084:Ubiquitin-Specific Peptidase 7
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7; C534425:MIR205, human; C464569:USP7 protein, human