title: Immuno-metabolism and adipose tissue: The key role of hematopoietic stem cells.
abstract: The field of immunometabolism has come a long way in the past decade, leading to the emergence of a new role for white adipose tissue (WAT) that is now recognized to stand at the junction of immune and metabolic regulations. Interestingly, a crucial role of the abundant and heterogeneous immune population present in WAT has been proposed in the induction and development of metabolic diseases. Although a large body of data focused on mature immune cells, only few scattered studies are dedicated to leukocyte production, and the activity of hematopoietic stem cells (HSC) in these pathological states. Considering that blood cell production and the differentiation of HSCs and their progeny is orchestrated, in part, by complex interacting signals emanating from their microenvironment, it thus seems worth to better understand the relationships between metabolism and HSC. This review discusses the alterations of hematopoietic process described in metabolic diseases and focused on the emerging data concerning HSC present in WAT.
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France. Electronic address: beatrice.cousin@inserm.fr.
authors.forename: B
authors.initials: B
authors.lastname: Cousin
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France.
authors.forename: L
authors.initials: L
authors.lastname: Casteilla
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France; Laboratoire d'Hématologie, TSA 50032, F-31059 Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Laharrague
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France.
authors.forename: E
authors.initials: E
authors.lastname: Luche
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France.
authors.forename: A
authors.initials: A
authors.lastname: Lorsignol
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France.
authors.forename: V
authors.initials: V
authors.lastname: Cuminetti
authors.affiliation: CNRS 5273, UMR STROMALab, F-31 432 Toulouse Cedex 4, France; Université de Toulouse 3, UPS, F-31 432 Toulouse Cedex 4, France; INSERM U1031, F-31 432 Toulouse Cedex 4, France; EFS Pyrénées -Méditerranée, BP 84225, F-31 432 Toulouse Cedex 4, France.
authors.forename: J
authors.initials: J
authors.lastname: Paupert
mesh_terms: D052436:Adipose Tissue, White / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006410:Hematopoiesis / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008659:Metabolic Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000276:immunology*
keywords: Adipose tissue; Bone marrow; Diabetes; Hematopoietic stem cell; Metabolism; Obesity