title: Inflammatory and Other Biomarkers: Role in Pathophysiology and Prediction of Gestational Diabetes Mellitus.
abstract: Understanding pathophysiology and identifying mothers at risk of major pregnancy complications is vital to effective prevention and optimal management. However, in current antenatal care, understanding of pathophysiology of complications is limited. In gestational diabetes mellitus (GDM), risk prediction is mostly based on maternal history and clinical risk factors and may not optimally identify high risk pregnancies. Hence, universal screening is widely recommended. Here, we will explore the literature on GDM and biomarkers including inflammatory markers, adipokines, endothelial function and lipids to advance understanding of pathophysiology and explore risk prediction, with a goal to guide prevention and treatment of GDM.
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia. sally.abell@monash.edu.|Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia. sally.abell@monash.edu.
authors.forename: Sally K
authors.initials: SK
authors.lastname: Abell
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia. barbora.decourten@monash.edu.|Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia. barbora.decourten@monash.edu.
authors.forename: Barbora
authors.initials: B
authors.lastname: De Courten
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia. jacqueline.boyle@monash.edu.|Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia. jacqueline.boyle@monash.edu.|Monash Women's Services, Monash Health, Clayton 3168, Australia. jacqueline.boyle@monash.edu.
authors.forename: Jacqueline A
authors.initials: JA
authors.lastname: Boyle
authors.affiliation: Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia. helena.teede@monash.edu.|Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia. helena.teede@monash.edu.
authors.forename: Helena J
authors.initials: HJ
authors.lastname: Teede
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators
keywords: biomarkers; gestational diabetes mellitus; inflammatory markers; pregnancy; risk prediction