title: Metabolic syndrome resolution by Roux-en-Y gastric bypass in a real world: a case control study.
abstract: OBJECTIVE
  the aim of this study was to evaluate the efficacy of Roux-en-Y Gastric Bypass (RYGB), compared with nonsurgical treatment (NS group), as an instrument for inducing remission of co-morbidities related to Metabolic Syndrome (MetS) in patients with Obesity, grades 2 and 3 (Ob2,3).
  
  
  METHODS
  two hundred and fifty eight Ob2,3 patients were selected in a retrospective analysis and included in a case control study. MetS was defined as described by the International Diabetes Federation. One hundred and twenty-nine of these patients underwent RYGB (S group), and 129 were assessed as an NS group.
  
  
  RESULTS
  at baseline, S and NS groups did not differ in BMI, age, female sex and prevalence of MetS (p>0.05). For the S group the outcomes were a reduction in BMI of 38.1% (p<0.001), waist circumference of 28.6% (p<0.001), fasting plasma glucose of 10.5% (p<0.001), serum LDL-cholesterol of 21.9% (p<0.001) and of 85% in the number of patients with MetS (p<0.001). For the NS group, only a decrease of 4.12%(p=0.047) in triglyceride levels and of 5.9%(p=0.031) in Diastolic Blood Pressure was observed. In the NS group, 98.6% of the patients continued to have MetS. The number needed to treat (NNT) with surgery to resolve one case of MetS was 1.2 (CI 95%: 1.1 - 1.4).
  
  
  CONCLUSIONS
  in the real world, in the South of Brazil, compared with NS treatment and after 1 year of observation, RYGB is highly effective for decreasing the prevalence of MetS.
authors.affiliation: Hospital das Clínicas de Porto Alegre, Santa Casa de Porto Alegre, Universidade Federal do Rio Grande do Sul, RS, Brazil.
authors.forename: Helena
authors.initials: H
authors.lastname: Schmid
authors.affiliation: Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Claudio Fernando
authors.initials: CF
authors.lastname: Goelzer Neto
authors.affiliation: PPGGO, UFRGS, Porto Alegre, RS, Brazil.
authors.forename: Lisiane Stefani
authors.initials: LS
authors.lastname: Dias
authors.affiliation: Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Weston
authors.affiliation: Santa Casa de Porto Alegre, RS, Brazil.
authors.forename: Marília Bittencourt
authors.initials: MB
authors.lastname: Espíndola
authors.affiliation: Santa Casa de Porto Alegre, RS, Brazil.
authors.forename: Sergio Ricardo
authors.initials: SR
authors.lastname: Pioner
authors.affiliation: Santa Casa de Porto Alegre, RS, Brazil.
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: De Carli
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001938:Brazil; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D024821:Metabolic Syndrome / Q000628:therapy*; D009765:Obesity / Q000378:metabolism; D009767:Obesity, Morbid / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055105:Waist Circumference; D015431:Weight Loss