title: Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.
abstract: Caffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the free radicals. This study aimed to investigate the radioprotective effects of CAPE on X-ray irradiation induced intestinal injury in rats. Rats were intragastrically administered with 10 μmol/kg/d CAPE for 7 consecutive days before exposing them to a single dose of X-ray irradiation (9Gy) to abdomen. Rats were sacrificed 72 h after exposure to radiation. We found that pretreatment with CAPE effectively attenuated intestinal pathology changes, apoptosis, oxidative stress, bacterial translocation, the content of nitric oxide and myeloperoxidase as well as the concentration of plasma tumor necrosis factor-α. Pretreatment with CAPE also reversed the activation of p38MAPK and the increased expression of intercellular cell adhesion molecule-1 induced by radiation in intestinal mucosa. Taken together, these results suggest that pretreatment with CAPE could be a promising candidate for treating radiation-induced intestinal injury.
authors.affiliation: Department of Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China.
authors.forename: Liu-Gen
authors.initials: LG
authors.lastname: Jin
authors.affiliation: Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Chu
authors.affiliation: Wuxi Medical School, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Pang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China.
authors.forename: Fu-Zheng
authors.initials: FZ
authors.lastname: Zhang
authors.affiliation: Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China.
authors.forename: Le-Yuan
authors.initials: LY
authors.lastname: Zhou
authors.affiliation: Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China. Electronic address: xcg12345@qq.com.
authors.forename: Chun-Gen
authors.initials: CG
authors.lastname: Xing
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002109:Caffeic Acids / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011839:Radiation, Ionizing; D051381:Rats; D017207:Rats, Sprague-Dawley; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D002109:Caffeic Acids; D048051:p38 Mitogen-Activated Protein Kinases; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol
keywords: Apoptosis; Caffeic acid phenethyl ester; Intestine; Radiation; p38MAPK