title: Acute Myeloid Leukemia Diagnosed 5 Years after Adult T-Cell Leukemia/Lymphoma.
abstract: A case of secondary acute myeloid leukemia (AML) was identified following adult T-cell leukemia/lymphoma (ATL), for which combination chemotherapy had been administered, including epipodophyllotoxin, anthracycline, and alkylating agents. AML with maturation was diagnosed by the cytological findings, cell surface markers, and chromosomal abnormalities. We previously reported two cases of AML accompanied by ATL. In this case of AML after chemotherapy for ATL, we considered that the AML was probably associated with previous chemotherapy for ATL. Although the ATL remained in remission, the therapy-related AML with complex chromosomal abnormalities proved resistant to chemotherapy, and the patient died from complications associated with AML.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Owatari
authors.forename: Akihiko
authors.initials: A
authors.lastname: Arai
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tsuruta
authors.forename: Koichi
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Maki
authors.initials: M
authors.lastname: Otsuka
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hanada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*