title: Visual Field Progressive Rate in Normal Tension Glaucoma Before and After Trabeculectomy: A Subfield-Based Analysis.
abstract: OBJECTIVE
  To compare pretrabeculectomy and posttrabeculectomy progression rates in normal-tension glaucoma in 6 subfields of the central 30 visual field.
  
  
  METHODS
  A retrospective study.
  
  
  METHODS
  Clinical records of 34 patients with normal-tension glaucoma (12 males and 22 females) with progressive visual field loss undergoing successful trabeculectomy were studied. The time course of the mean deviation (MD) and mean of total deviation in the superior/inferior arcuate, paracentral, and cecocentral subfields were analyzed using a linear mixed-effects model.
  
  
  RESULTS
  Patients' age, intraocular pressure (IOP), MD, and pretrabeculectomy and posttrabeculectomy follow-up averaged 57.7 ± 9.6 years, 15.7 ± 1.7 mm Hg, -12.7 ± 5.5 dB, and 4.6 ± 1.5 and 5.7 ± 1.2 years, respectively. Average IOP was lowered by 6.1 ± 3.3 to 10.3 ± 2.7 mm Hg (5-14 mm Hg) over the postoprerative period with MD change rate of -0.25 dB/y (P < 0.003), which was slower (P < 0.001) than the preoperative one (-0.70 dB/y). The preoperative mean of total deviation change rate (-0.31 to -1.35 dB/y) improved postoperatively in the superior and inferior paracentral subfields (P < 0.001), whereas it remained unchanged in the inferior cecocentral/arcuate subfields (P > 0.10). The postoperative rate of progression showed no significant variation in these subfields.
  
  
  CONCLUSIONS
  The rate of progression significantly varied among the 6 subfields preoperatively. It was significantly slowed down in the superior subfields by surgical IOP reduction, but not in the inferior cecocentral/arcuate subfields.
authors.affiliation: From the *Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, and †Division of Ophthalmology, Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo; and ‡Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Mataki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murata
authors.forename: Akira
authors.initials: A
authors.lastname: Sawada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Shigeeda
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie