title: Spot urine protein-creatinine ratio and 24-h urine protein excretion: Diagnostic accuracy in women with pre-eclampsia.
abstract: OBJECTIVE
  To compare the efficacy of spot urinary protein/creatinine ratio with 24h urinary protein excretion in women with pre-eclampsia.
  
  
  METHODS
  A total of 85 women with hypertensive disorders during pregnancy were prospectively studied. Urine protein/creatinine ratio in spot urine sample was compared with 24h urinary protein. Sensitivity and specificity for urinary spot P/C (protein/creatinine) ratio was assessed, and receiver operating curve was used to determine the value against the gold standard of >300mg proteinuria in 24h urinary sample.
  
  
  RESULTS
  Of 85 women, complete data were available for 81 women. There was a strong correlation between spot urinary P/C ratio and 24h urine protein excretion (r=0.81, P value <0.000). The optimal spot P/C ratio cut-off point was 0.14 for 300mg/24h of protein excretion (preeclampsia) with a sensitivity of 82% and specificity of 79%.
  
  
  CONCLUSIONS
  We found a strong correlation between spot urinary P/C and 24h urinary protein. Spot urinary protein/creatinine ratio is a good predictor of proteinuria for pre-eclampsia.
authors.affiliation: Department of Obstetrics & Gynecology Unit II, Dow University of Health Sciences, Karachi, Pakistan. Electronic address: Nazli.hossain@duhs.edu.pk.
authors.forename: Nazli
authors.initials: N
authors.lastname: Hossain
authors.affiliation: Department of Research & Biostatistics, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Nazeer
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Obstetrics & Gynecology Unit III, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Nusrat
authors.initials: N
authors.lastname: Shah
authors.affiliation: Department of Obstetrics & Gynecology Unit III, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Tahira
authors.initials: T
authors.lastname: Shah
authors.affiliation: Department of Obstetrics & Gynecology Unit III, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Sofia
authors.initials: S
authors.lastname: Butt
authors.affiliation: Dow Diagnostics & Reference Lab, Dow University of Health Sciences, Karachi, Pakistan.
authors.forename: Rafiq
authors.initials: R
authors.lastname: Khanani
keywords: Pakistan; Pre-eclampsia; Proteinuria; Spot urinary protein/creatinine ratio