title: Phenotype-Driven Plasma Biobanking Strategies and Methods.
abstract: Biobank development and integration with clinical data from electronic medical record (EMR) databases have enabled recent strides in genomic research and personalized medicine. BioVU, Vanderbilt's DNA biorepository linked to de-identified clinical EMRs, has proven fruitful in its capacity to extensively appeal to numerous areas of biomedical and clinical research, supporting the discovery of genotype-phenotype interactions. Expanding on experiences in BioVU creation and development, we have recently embarked on a parallel effort to collect plasma in addition to DNA from blood specimens leftover after routine clinical testing at Vanderbilt. This initiative offers expanded utility of BioVU by combining proteomic and metabolomic approaches with genomics and/or clinical outcomes, widening the breadth for potential research and subsequent future impact on clinical care. Here, we describe the considerations and components involved in implementing a plasma biobank program from a feasibility assessment through pilot sample collection.
authors.affiliation: Institute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. erica.a.bowton@vanderbilt.edu.
authors.forename: Erica A
authors.initials: EA
authors.lastname: Bowton
authors.affiliation: Institute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. sarah.p.collier@vanderbilt.edu.
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Collier
authors.affiliation: Institute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. sunny.wang@vanderbilt.edu.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Vanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. cara.b.sutcliffe@vanderbilt.edu.
authors.forename: Cara B
authors.initials: CB
authors.lastname: Sutcliffe
authors.affiliation: Departments of Pediatrics and Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. sara.van.driest@vanderbilt.edu.
authors.forename: Sara L
authors.initials: SL
authors.lastname: Van Driest
authors.affiliation: Vanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. lindsayjcouch@gmail.com.
authors.forename: Lindsay J
authors.initials: LJ
authors.lastname: Couch
authors.affiliation: Vanderbilt Technologies for Advanced Genomics Core Facility, Vanderbilt University, Nashville, TN 37232, USA. miguel.herrera@vanderbilt.edu.
authors.forename: Miguel
authors.initials: M
authors.lastname: Herrera
authors.affiliation: Institute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. rebecca.jerome@vanderbilt.edu.
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Jerome
authors.affiliation: Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. r.slebos@vanderbilt.edu.|Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. r.slebos@vanderbilt.edu.
authors.forename: Robbert J C
authors.initials: RJ
authors.lastname: Slebos
authors.affiliation: Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. william.alborn@vanderbilt.edu.|Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. william.alborn@vanderbilt.edu.
authors.forename: William E
authors.initials: WE
authors.lastname: Alborn
authors.affiliation: Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University, Nashville, TN 37232, USA. daniel.liebler@vanderbilt.edu.|Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. daniel.liebler@vanderbilt.edu.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Department of Emergency Medicine, Vanderbilt University, Nashville, TN 37232, USA. candace.mcnaughton@vanderbilt.edu.
authors.forename: Candace D
authors.initials: CD
authors.lastname: McNaughton
authors.affiliation: Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. r.mernaugh@vanderbilt.edu.
authors.forename: Ray L
authors.initials: RL
authors.lastname: Mernaugh
authors.affiliation: Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. quinn.s.wells@vanderbilt.edu.|Vanderbilt Translational and Clinical Cardiovascular (VTRACC) Research Group, Vanderbilt University Medical Center, Nashville, TN 37232, USA. quinn.s.wells@vanderbilt.edu.
authors.forename: Quinn S
authors.initials: QS
authors.lastname: Wells
authors.affiliation: Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. nancy.j.brown@vanderbilt.edu.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Brown
authors.affiliation: Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. dan.roden@vanderbilt.edu.
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
authors.affiliation: Institute for Clinical and Translational Research, Vanderbilt University, Nashville, TN 37203, USA. jill.pulley@vanderbilt.edu.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Pulley
keywords: BioVU; biobanking; biorepository; plasma; proteomics