title: 'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung.
abstract: We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.
authors.affiliation: Department of Perinatal and Pulmonary Biology, The Perinatal Institute and Section of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Yina
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Perinatal and Pulmonary Biology, The Perinatal Institute and Section of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Minzhe
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Perinatal and Pulmonary Biology, The Perinatal Institute and Section of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Whitsett
authors.affiliation: Department of Perinatal and Pulmonary Biology, The Perinatal Institute and Section of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods*; D015870:Gene Expression; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D020407:Internet; D008168:Lung / Q000254:growth & development* / Q000378:metabolism; D012984:Software; D014157:Transcription Factors
chemical_list: D014157:Transcription Factors
keywords: Airway Epithelium; Surfactant protein; Systemic disease and lungs; TTF-1