title: A case of lung adenocarcinoma with a concurrent EGFR mutation and ALK rearrangement: A case report and literature review.
abstract: The echinoderm microtubule associated protein like 4‑anaplastic lymphoma kinase (EML4‑ALK) fusion is almost mutually exclusive to epidermal growth factor receptor (EGFR) or K‑RAS mutation in non‑small cell lung cancer (NSCLC), and it is extremely rare for patients to exhibit both mutations. The present study reported the case of a 71-year‑old female diagnosed with adenocarcinoma, exhibiting mutations in EGFR and EML4‑ALK. The present study treated this patient with EGFR‑TK inhibitors, as the first line therapy, and geﬁtinib therapy revealed a good response until now. In addition, previously reported cases and associated literature were reviewed. The present study provided a greater understanding of the molecular biology and optimal treatment for patients with NSCLC with >1 driver mutation.
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Xu
authors.affiliation: Department of Internal Medicine, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China.
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Cai
authors.affiliation: Department of Surgical Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Department of Oncology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Oncology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Shi
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Zhang
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Wang
authors.affiliation: Department of Pathology, The General Military Hospital of Beijing PLA, Beijing 100700, P.R. China.
authors.forename: Yu-Wang
authors.initials: YW
authors.lastname: Tian
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000235:genetics / Q000556:secondary; D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000556:secondary; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011859:Radiography; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: C522504:EML4-ALK fusion protein, human; D015514:Oncogene Proteins, Fusion; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; C512478:EGFR protein, human; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases