title: Safety of a second-generation tyrosine kinase inhibitor and novel targeted therapy for the treatment of a patient with chronic myeloid leukemia and multiple myeloma.
abstract: The prevalence of chronic myeloid leukemia and multiple myeloma has increased in recent years partly because of an improved therapeutic armamentarium for both conditions. Likewise, understanding the complexity inherent in designing combination treatment strategies will become increasingly prescient in the coming years. We describe, to the best of our knowledge, the first reported patient to be treated with second-generation tyrosine kinase inhibitor therapy while on novel therapy for myeloma. The combination was well tolerated and effective for the treatment of chronic myeloid leukemia and concurrent myeloma.
authors.affiliation: Departments of aOncology bOncology Pharmacy, Kaiser Permanente, Santa Clara, California cJohn Theurer Cancer Center, Hackensack UMC, Hackensack, New Jersey, USA.
authors.forename: Jed A
authors.initials: JA
authors.lastname: Katzel
authors.forename: Annette
authors.initials: A
authors.lastname: Lee-Ma
authors.forename: David H
authors.initials: DH
authors.lastname: Vesole
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011719:Pyrazines / Q000008:administration & dosage; D011743:Pyrimidines / Q000008:administration & dosage
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D011743:Pyrimidines; D000069286:Bortezomib; D003907:Dexamethasone; D011505:Protein-Tyrosine Kinases; C498826:nilotinib