title: Immune-mediated Neuropathy with Anti-disialosyl IgM Antibodies in Diffuse Large B-cell Lymphoma: A Case Report and Literature Review.
abstract: A 36-year-old man with diffuse large B-cell lymphoma presented with polyneuropathy, and the diagnostic work-up revealed the presence of IgM antibodies against gangliosides with disialosyl residues (GD1b, GD3). He was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone and received high-dose intravenous immunoglobulin for the treatment of neuropathy. After initiating the treatments, the patient's neurological impairment improved dramatically. He currently remains in complete remission without a flare-up of the polyneuropathy. Based upon our experience and other case reports of lymphoma with immune-mediated neuropathy caused by anti-disialosyl ganglioside IgM antibodies, we conclude that determining the anti-ganglioside antibody profile and beginning early treatment should be considered promptly for patients with malignant lymphoma who develop polyneuropathy.
authors.affiliation: Department of Neurology, Keio University School of Medicine, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Shihashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Yagi
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Suzuki
authors.forename: Morinobu
authors.initials: M
authors.lastname: Seki
authors.forename: Sumiko
authors.initials: S
authors.lastname: Kohashi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ueda
authors.forename: Kaori
authors.initials: K
authors.lastname: Kameyama
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Okamoto
authors.forename: Norihiro
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000906:Antibodies; D005732:Gangliosides; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors