title: Viremia during pregnancy and risk of childhood leukemia and lymphomas in the offspring: Nested case-control study.
abstract: A possible role for infections of the pregnant mother in the development of childhood acute leukemias and lymphomas has been suggested. However, no specific infectious agent has been identified. Offspring of 74,000 mothers who had serum samples taken during pregnancy and stored in a large-scale biobank were followed up to the age of 15 years (750,000 person years) through over-generation linkages between the biobank files, the Swedish national population and cancer registers to identify incident leukemia/lymphoma cases in the offspring. First-trimester sera from mothers of 47 cases and 47 matched controls were retrieved and analyzed using next generation sequencing. Anelloviruses were the most common viruses detected, found in 37/47 cases and in 40/47 controls, respectively (OR: 0.6, 95% CI: 0.2-1.9). None of the detected viruses was associated with leukemia/lymphoma in the offspring. Viremia during pregnancy was common, but no association with leukemia/lymphoma risk in the offspring was found.
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.
authors.forename: Davit
authors.initials: D
authors.lastname: Bzhalava
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.
authors.forename: Emilie
authors.initials: E
authors.lastname: Hultin
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.
authors.forename: Laila Sara
authors.initials: LS
authors.lastname: Arroyo Mühr
authors.affiliation: Department of Clinical Sciences, Lund University, Malmö, Sweden.
authors.forename: Johanna
authors.initials: J
authors.lastname: Ekström
authors.affiliation: National Institute for Health and Welfare, Oulu, Finland.
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.affiliation: Abteilung Tumorvirus-Charakterisierung, Deutsches Krebsforschungszentrum, Heidelberg, 69120, Germany.
authors.forename: Ethel-Michele
authors.initials: EM
authors.lastname: de Villiers
authors.affiliation: Department of Laboratory Medicine, Karolinska Institutet, Stockholm, SE-141 86, Sweden.|Department of Medical Epidemiology & Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
mesh_terms: D016022:Case-Control Studies; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000821:virology; D012307:Risk Factors; D014766:Viremia / Q000150:complications*
keywords: anelloviruses; childhood leukemias and lymphomas; infections; metagenomics; next generation sequencing