title: [Expression and significance of C/EBPα and CK10 in nasal inverted papilloma].
abstract: OBJECTIVE
  The expression of C/EBPα, CK10 in nasal inverted papilloma (NIP) were detected in the study. Further discussed their significance in genesia, development and recurrence of NIP.
  
  
  METHODS
  Three groups including nasal cavity mucosae (NM 10 cases), nasal polyp (NP 20 cases) and NIP (30 cases) were selected in the study. Expretion of C/EBPα, CK10 were detected by immunohistochemisty PV-6000 method.
  
  
  RESULTS
  (1) The different expression of C/EBPα and CK10 in the group of NM, NP and NIP was statistically significant (P < 0.05). (2) The different expression of C/EBPα, CK10 in the group of benign NIP and NIP with atypical hyperplasia was statistically significant (P < 0.05). (3) The different expression of C/EBPα and CK10 in the group of NIP with recurrence and NIP with no recurrence was statistically significant, P < 0.05, respectively. (4) Our result indicate that the relationship of C/EBPα and CK10 (r = 0.578, P < 0.01) was direct correlation. The difference was statistically significant.
  
  
  CONCLUSIONS
  In conclusion, the present results describe C/EBPα, CK10 expression in NIP and their possible implication in the regulation of tumor growth and differentiation. C/EBPα and CK10 production may prove useful in terms of a prognostic marker for the recurrence in nasal inverted papilloma.
authors.forename: Yibing
authors.initials: Y
authors.lastname: Yaun
authors.forename: Xianying
authors.initials: X
authors.lastname: Meng
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D053550:Keratin-10 / Q000235:genetics / Q000378:metabolism*; D009298:Nasal Polyps / Q000235:genetics / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D009666:Nose; D009669:Nose Neoplasms / Q000235:genetics / Q000378:metabolism*; D018308:Papilloma, Inverted / Q000235:genetics / Q000378:metabolism*
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; C507493:KRT10 protein, human; D053550:Keratin-10