title: Modular, Concise, and Efficient Synthesis of Highly Functionalized 5-Fluoropyridazines by a [2 + 1]/[3 + 2]-Cycloaddition Sequence.
abstract: An easy access to 5-fluoropyridazines by a [2 + 1]/[3 + 2]-cycloaddition sequence between terminal alkynes, a difluorocarbene, and a diazo compound is reported. This approach does not necessitate the isolation of any intermediates, and a wide range of novel 5-fluoropyridazines was synthesized from readily available starting materials. Additionally, these compounds were used as a platform to access novel and highly diversified pyridazines.
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Tran
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Domingo
authors.initials: D
authors.lastname: Gomez Pardo
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tsuchiya
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Stefan
authors.initials: S
authors.lastname: Hillebrand
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), ESPCI ParisTech, UMR 8231, PSL Research University. 10 rue Vauquelin, Paris 75231 Cedex 05, France.
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001391:Azo Compounds; D006845:Hydrocarbons, Fluorinated; D011724:Pyridazines; C121084:difluorocarbene