title: Xp11.2 translocation renal cell carcinomas in young adults.
abstract: BACKGROUND
  Little is known about the biological behavior of Xp11.2 translocation renal cell carcinomas (RCCs) as few clinical studies have been performed using a large sample size.
  
  
  METHODS
  This study included 103 consecutive young adult patients (age ≤ 45 years) with RCC who underwent partial or radical nephrectomy at our institution from 2008 to 2013. Five patients without complete clinical data were excluded. Of the 98 remaining patients, 16 and 82 patients were included in the Xp11.2 translocation and non-Xp11.2 translocation groups, respectively. Clinicopathologic data were collected, including age, gender, tumor size, laterality, symptoms at diagnosis, surgical procedure, pathologic stage, tumor grade, time of recurrence and death.
  
  
  RESULTS
  Xp11.2 translocation RCCs were associated with higher tumor grade and pathologic stage (P < 0.05, Fisher's exact test). During the median follow-up of 36 months (range: 3-71 months), the number of cancer-related deaths was 4 (4.9%) and 3 (18.7%) in the non-Xp11.2 translocation and Xp11.2 translocation groups, respectively. The Kaplan-Meier cancer specific survival curves revealed a significant difference between non-Xp11.2 translocation RCCs and Xp11.2 translocation RCCs in young adults (P = 0.042).
  
  
  CONCLUSIONS
  Compared with non-Xp11.2 translocation RCCs, the Xp11.2 translocation RCCs seemingly showed a higher tumor grade and pathologic stage and have similar recurrence-free survival rates but poorer cancer-specific survival rates in young adults.
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. dalaoxu1107@sina.com.
authors.forename: Linfeng
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. doctoryr@gmail.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. gwd@nju.edu.cn.
authors.forename: Weidong
authors.initials: W
authors.lastname: Gan
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. 583949288@qq.com.
authors.forename: Xiancheng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. Hydewoods@gmail.com.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. dr.fukai1988@gmail.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Fu
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. 583949288@qq.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. 421092748@qq.com.
authors.forename: Guancheng
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Department of Urology, The Affiliated Drum Tower Hospital of Medical College of Nanjing University, Zhongshan Road 321, Nanjing, Jiangsu Province, 210008, China. doctorghq@gmail.com.
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000401:mortality* / Q000601:surgery; D002681:China / Q000453:epidemiology; D041321:Chromosomes, Human, X / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality* / Q000517:prevention & control; D018570:Risk Assessment; D015996:Survival Rate; D000091262:TEA Domain Transcription Factors; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; D009124:Muscle Proteins; D000091262:TEA Domain Transcription Factors; C486309:TEAD4 protein, human; D014157:Transcription Factors