title: Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients.
abstract: The adipose tissue is not only an inert storage depot for lipids, but also it secretes a variety of bioactive molecules, known as adipokines, which affect whole-body homeostasis. Adiponectin is the most abundant of these adipocytokines and is known to have a regulatory effect on the metabolism of glucose and lipid. The main objectives of this study were to evaluate the serum levels of adiponectin and to establish a correlation between adiponectin serum levels and the degree of insulin resistance in type 2 diabetic patients. Eighty participants were enrolled in this study; 61 type 2 diabetic patients and 19 apparently healthy subjects. Serum level of adiponectin was measured by enzyme-linked immunosorbent assay (ELISA) for each participant. Data collection sheet was filled with all required information for each participant. Adiponectin level in the diabetic patients (5.05 ± 2.61 μg/ml) was lower than in non-diabetic healthy controls (5.71 ± 2.35 μg/ml). When the results were compared according to gender, diabetic females showed significantly higher adiponectin levels (5.76 ± 2.64 μg/ml) than diabetic males (4.366 ± 2.43 μg/ml, P = 0.035). In addition, female diabetic patients with abdominal obesity (waist circumference (WC) ⩾ 88 cm) had lower adiponectin levels (5.58 ± 2.58 μg/ml) than diabetic females without abdominal obesity (6.96 ± 3.12 μg/ml). The correlation analysis indicated that adiponectin had a significant positive correlation with age (r = -0.450, P < 0.001). In conclusion, female diabetic patients had a statistically significant higher adiponectin level than male diabetic patients which could indicate a gender effect. Adiponectin levels were inversely related to insulin resistance; as patients with abdominal obesity had lower serum levels of adiponectin.
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan.
authors.forename: Shereen
authors.initials: S
authors.lastname: Aleidi
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan.
authors.forename: Ala
authors.initials: A
authors.lastname: Issa
authors.affiliation: National Center for Diabetes, Endocrinology, and Genetics, Amman, Jordan.
authors.forename: Haidar
authors.initials: H
authors.lastname: Bustanji
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Khalil
authors.affiliation: Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Bustanji
keywords: Abdominal obesity; Adiponectin; Diabetes mellitus; Gender; Insulin resistance; Jordan