title: Influence of Retirement on Adherence to Statins in the Insurance Medicine All-Sweden Total Population Data Base.
abstract: BACKGROUND
  Retirement has been suggested to reduce medication adherence, but no evidence is available for statins. We investigated changes in adherence to statins among Swedish adults after retirement.
  
  
  METHODS
  A prospective cohort study was carried out on all individuals living in Sweden on 31 December 2004, alive in 2010, having purchased statins in the second half of 2005, and retired in 2008 (n=11 718). We used prescription dispensing data in 2006-2010 to determine nonadherence (defined as <80% of days covered by filled prescriptions) before and after old-age or disability retirement. Using multiple repeat measurements of filled statin prescriptions, we calculated the annual prevalence rates of nonadherence for those who continued therapy. Discontinuation was defined as no statin dispensations during a calendar year.
  
  
  RESULTS
  After adjustment for age at retirement, the prevalence ratio (PR) of nonadherence after retirement in comparison with those before retirement was 1.23 [95% confidence interval (CI) 1.17-1.29] for the men and 1.19 (95% CI 1.13-1.26) for the women. A post-retirement increase in nonadherence was consistently observed across the strata of age at retirement, marital status, education, income, type of retirement, and participants with and without cardiovascular disease, the largest increases being observed for statin use in secondary prevention (men: PR 1.38, 95% CI 1.26-1.54; women: PR 1.43, 1.18-1.72). For primary prevention, the corresponding prevalence ratios were 1.18 (95% CI 1.13‒1.25) and 1.18 (95% CI 1.11-1.24), respectively.
  
  
  CONCLUSIONS
  Retirement appears to be associated with increased nonadherence to statin therapy among Swedish men and women.
authors.affiliation: Department of Public Health, University of Turku, Turku, Finland.
authors.forename: Heli
authors.initials: H
authors.lastname: Halava
authors.affiliation: Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Hugo
authors.initials: H
authors.lastname: Westerlund
authors.affiliation: Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.
authors.forename: Maarit Jaana
authors.initials: MJ
authors.lastname: Korhonen
authors.affiliation: Finnish Institute of Occupational Health, Turku, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Pentti
authors.affiliation: Department of Epidemiology and Public Health, University College of London, London, United Kingdom.
authors.forename: Mika
authors.initials: M
authors.lastname: Kivimäki
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Linnea
authors.initials: L
authors.lastname: Kjeldgård
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Kristina
authors.initials: K
authors.lastname: Alexanderson
authors.affiliation: Department of Public Health, University of Turku, Turku, Finland; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Finnish Institute of Occupational Health, Turku, Finland; Turku University Hospital, Turku, Finland.
authors.forename: Jussi
authors.initials: J
authors.lastname: Vahtera
mesh_terms: D000328:Adult; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D050171:Dyslipidemias / Q000188:drug therapy / Q000517:prevention & control; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007182:Income; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011322:Primary Prevention; D011446:Prospective Studies; D012179:Retirement / Q000523:psychology*; D055502:Secondary Prevention; D019821:Simvastatin / Q000627:therapeutic use; D013548:Sweden / Q000453:epidemiology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin