title: Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients.
abstract: MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n=10) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry.The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation <3 °C). No unwanted heating in the near field (i.e. skin) nor in the far field (pectoral muscle) was detected.The newly developed dedicated breast MR-HIFU system allows for safe, accurate and precise ablation of breast tumors.
authors.affiliation: Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Deckers
authors.forename: L G
authors.initials: LG
authors.lastname: Merckel
authors.forename: B
authors.initials: B
authors.lastname: Denis de Senneville
authors.forename: G
authors.initials: G
authors.lastname: Schubert
authors.forename: M
authors.initials: M
authors.lastname: Köhler
authors.forename: F M
authors.initials: FM
authors.lastname: Knuttel
authors.forename: W P Th M
authors.initials: WP
authors.lastname: Mali
authors.forename: C T W
authors.initials: CT
authors.lastname: Moonen
authors.forename: M A A J
authors.initials: MA
authors.lastname: van den Bosch
authors.forename: L W
authors.initials: LW
authors.lastname: Bartels
mesh_terms: D001940:Breast / Q000166:cytology; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D003287:Contrast Media / Q000378:metabolism; D005260:Female; D064368:Healthy Volunteers; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*; D009361:Neoplasm Invasiveness; D013696:Temperature; D062125:Thermometry / Q000379:methods*
chemical_list: D003287:Contrast Media