title: Thiazole formation through a modified Gewald reaction.
abstract: The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Mallia
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Lukas
authors.initials: L
authors.lastname: Englert
authors.affiliation: Syngenta CP R&D Chemistry, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, United Kingdom.
authors.forename: Gary C
authors.initials: GC
authors.lastname: Walter
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
keywords: 1,4-dithiane-2,5-diol; Gewald reaction; design of experiment (DOE); thiazole; thiophene