title: Personal history of rosacea and risk of incident cancer among women in the US.
abstract: BACKGROUND
  Rosacea is an inflammatory skin disease. We examined the association between personal history of rosacea and risk of incident cancers.
  
  
  METHODS
  A total of 75 088 whites were included from the Nurses' Health Study II (1991-2011). Information on clinician-diagnosed rosacea and diagnosis year was collected in 2005. All cancers other than basal cell carcinoma (BCC) were confirmed.
  
  
  RESULTS
  During 1 447 205 person-years, we identified 5194 cases with internal malignancies and 5788 with skin cancers. We did not observe significant associations between personal history of rosacea and internal malignancies, except for thyroid cancer (hazard ratio (HR)=1.59, 95% confidence interval (CI)=1.07-2.36). Among skin cancers, personal history of rosacea was associated with an elevated risk of BCC (HR=1.50, 95% CI=1.35-1.67).
  
  
  CONCLUSIONS
  We suggest possible associations between personal history of rosacea and an increased risk of thyroid cancer and BCC. Further studies are warranted to replicate our findings and to explore the underlying mechanisms.
authors.affiliation: 1] Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA [2] Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
authors.forename: W-Q
authors.initials: WQ
authors.lastname: Li
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Surgery (Dermatology), Geisel School of Medicine at Dartmouth, Manchester, NH 03755, USA.
authors.forename: F W
authors.initials: FW
authors.lastname: Danby
authors.affiliation: 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA [2] Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN 46202, USA [3] Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA.
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.affiliation: 1] Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA [2] Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA [3] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000453:epidemiology*; D009726:Nurses / Q000706:statistics & numerical data; D012307:Risk Factors; D012393:Rosacea / Q000150:complications / Q000453:epidemiology*; D012878:Skin Neoplasms / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data