title: Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology.
abstract: Protein glycosylation is an important epigenetic modifying process affecting expression, localization, and function of numerous proteins required for normal immune function. Recessive germline mutations in genes responsible for protein glycosylation processes result in congenital disorders of glycosylation and can have profound immunologic consequences. Genetic mutations in immune signaling pathways that affect glycosylation sites have also been shown to cause disease. Sugar supplementation and in vivo alteration of glycans by medication holds therapeutic promise for some of these disorders. Further understanding of how changes in glycosylation alter immunity may provide novel treatment approaches for allergic disease, immune dysregulation, and immunodeficiency in the future.
authors.affiliation: Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD , USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Lyons
authors.affiliation: Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD , USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Milner
authors.affiliation: Immunology Service, Department of Laboratory Medicine, Clinical Center, National Institutes of Health , Bethesda, MD , USA ; Primary Immunodeficiency Clinic, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD , USA.
authors.forename: Sergio D
authors.initials: SD
authors.lastname: Rosenzweig
keywords: allergy; congenital disorders of glycosylation; glycosylation; immunodeficiency; infection susceptibility