title: The triplet puzzle theory indicates extensive formation of heteromers between opioid and chemokine receptor subtypes.
abstract: Biochemical studies had previously demonstrated examples of heteromerization between opioid and chemokine receptors. Based on the triplet puzzle theory, it has been discovered that opioid receptors are structurally more closely related to chemokine receptors than to other class A G-protein-coupled receptors. Their similarity is established in terms of the number of triplet homologies Asn-Leu-Ala, Thr-Leu-Pro, and Tyr-Ala-Phe in the amino acid code of extensive numbers of members of these two receptor groups. Such widespread similarities probably mean that many opioid and chemokine receptor subtypes utilize some of these mutual triplets to form heteromers. The findings underline that heteromerization among these two receptor groups can represent a major general mechanism for significant interactions between opioid peptides and chemokines in pain and neuroinflammation within the neural-glial networks of the CNS including immune cells.
authors.affiliation: Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia. sasha_tar@hotmail.com.
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Tarakanov
authors.affiliation: Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008958:Models, Molecular; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism*; D011957:Receptors, Opioid / Q000235:genetics / Q000378:metabolism*
chemical_list: D019707:Receptors, Chemokine; D011957:Receptors, Opioid
keywords: Chemokine receptors; Heteromers; Opioid receptors; Receptor interface; Receptor–receptor interactions; Triplet homologies