title: Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles.
abstract: Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacologically important polyheterocyclic systems through cascade palladium-catalyzed C-C bond formation processes. Allyl, homoallyl and propargylamine led to the formation of benzopyrrolizidinones, benzoindolizidinones and pyrazinoisoquinolines, respectively, while benzylamines and o-bromobenzylamines were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindiones.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S.N., Ciudad Universitaria, Coyoacán, México, D.F. O4510, Mexico. lmiranda@unam.mx.
authors.forename: Ma Carmen
authors.initials: MC
authors.lastname: García-González
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hernández-Vázquez
authors.forename: Raúl E
authors.initials: RE
authors.lastname: Gordillo-Cruz
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000737:chemistry; D001596:Benzylamines / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry
chemical_list: D001596:Benzylamines; D007211:Indoles; D007546:Isoquinolines; D011758:Pyrroles; D010165:Palladium; C015102:dehydroalanine; D000409:Alanine