title: THE SURPRISING DUAL ACTION OF GLUCOCORTICOIDS.
abstract: Glucocorticoid hormones may have dual action on the stomach: physiological gastroprotective and pathological proulcerogenic one. In physiological conditions, even in acute stress situations, glucocorticoids have an adaptive effect on the stomach and, therefore, are gastroprotective. The findings that we review in this article suggest that glucocorticoids released during acute stress are naturally occurring protective factors that play an important role in maintenance of the gastric mucosal integrity.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Filaretova
authors.forename: Gábor
authors.initials: G
authors.lastname: Makara
mesh_terms: D000208:Acute Disease; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D005938:Glucocorticoids / Q000009:adverse effects* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D020011:Protective Agents / Q000378:metabolism*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism*; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D020011:Protective Agents