title: Effect of variation of FGF2 genotypes on the risk of osteosarcoma susceptibly: a case control study.
abstract: OBJECTIVE
  Genetic factors play an important role in osteosarcoma (OS) etiology and fibroblast growth factor 2 (FGF2) gene single polymorphisms may be involved. The aim of this study was to test whether FGF2 variants are associated with susceptibility to OS in a Chinese population.
  
  
  METHODS
  A total of 151 subjects who were diagnosed as OS and 225 healthy age-matched controls were enrolled in the present study. Thers11737764 C/T SNP in FGF2 gene was genotyped in all the subjects. The SPSS software was used to investigate the association between the rs11737764 genotypes and OS susceptibility or severity.
  
  
  RESULTS
  The genotype frequencies of the FGF2 rs11737764 C/T polymorphism were 44.4% (CC), 50.3% (CT) and 5.3% (TT) in OS patients, and 55.6% (CC), 43.1% (CT) and 1.3% (TT) in controls. Rs11737764 C/T was found to be significantly associated with increased risk and OS no matter what genetic model was used.
  
  
  CONCLUSIONS
  In conclusion, our data demonstrated the FGF2 SNP rs11737764 was significantly associated with increased osteosarcoma susceptibility in Chinese Han Population.
authors.affiliation: Department of Spine Surgery, Yantaiyuhuangding Hospital Shangdong, China.
authors.forename: Jiefeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Spine Surgery, Yantaiyuhuangding Hospital Shangdong, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Spine Surgery, Yantaiyuhuangding Hospital Shangdong, China.
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Joint Surgery, Yantaiyuhuangding Hospital Shangdong, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Qi
keywords: FGF2; SNP; osteosarcoma