title: Mitigating Fear and Loathing in Managing Acute Myeloid Leukemia.
abstract: The contemporary care of patients with acute myeloid leukemia (AML) is made complex by potentially toxic treatments, continuously advancing science, aging patients, and individual treatment goals. By taking a survey of present-day approaches, we aim to dispel some of the trepidation surrounding that care of patients with AML. At the beginning is the initial presentation, and we will discuss whether or not AML should be considered a medical emergency. We will explore the complex realm of patient decision-making about initial therapy, including the intricate straits of patient-doctor communication, and available options for initial treatment. We will then address post-remission approaches and the controversies that lie therein, and survivorship issues. Finally, we will investigate the current role molecular assessments are playing in therapy recommendations.
authors.affiliation: Leukemia Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH. Electronic address: sekerem@ccf.org.
authors.forename: Mikkael A
authors.initials: MA
authors.lastname: Sekeres
authors.affiliation: Leukemia Program, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH.
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Gerds
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003657:Decision Making; D005239:Fear; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000523:psychology* / Q000628:therapy; D009154:Mutation; D010817:Physician-Patient Relations
chemical_list: D014408:Biomarkers, Tumor