title: Galectin-3 Expression in Primary Cutaneous CD30-Positive Lymphoproliferative Disorders and Transformed Mycosis Fungoides.
abstract: BACKGROUND
  In nodal anaplastic large cell lymphoma, strong expression of galectin-3 (Gal-3) has been found, but only very few cases of primary cutaneous lymphoma have so far been examined.
  
  
  OBJECTIVE
  To investigate 11 primary cutaneous anaplastic large cell lymphomas (PCALCL), 47 lymphomatoid papuloses (LYP) and 14 cases of transformed mycosis fungoides with CD30 expression (MF-T) for Gal-3 expression.
  
  
  METHODS
  A Gal-3 score was applied using a photo-based morphometric evaluation program. Double staining for CD30 and Gal-3 was performed. Furthermore, we recorded the cellular and extracellular sublocalization of the signal.
  
  
  RESULTS
  The Gal-3 expression in CD30+ tumor cells was significantly lower in MF-T in contrast to CD30+ lymphoproliferative disorders (CD30 LPD; p < 0.001), but we found no differences between PCALCL and LYP (p = 0.42). In PCALCL Gal-3 was more often localized in the cytoplasm in contrast to LYP, in which an equal distribution in the cytoplasm and the nucleus was more common (p = 0.9).
  
  
  CONCLUSIONS
  The lower Gal-3 expression in MF-T in comparison to CD30 LPD might be an additional criterion to differentiate both entities. The different sublocalization of the Gal-3 signal might reflect a different biological function and behavior.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Helios-Klinikum Hildesheim, Hildesheim, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Mitteldorf
authors.forename: Alistair
authors.initials: A
authors.lastname: Robson
authors.forename: Michael
authors.initials: M
authors.lastname: Tronnier
authors.forename: Monique C
authors.initials: MC
authors.lastname: Pfaltz
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins; D002467:Cell Nucleus / Q000737:chemistry; D002648:Child; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D037502:Galectin 3 / Q000032:analysis*; D037161:Galectins; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000737:chemistry / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000737:chemistry* / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000737:chemistry / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology*; D055815:Young Adult
chemical_list: D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; D017730:Ki-1 Antigen; C428445:LGALS3 protein, human