title: Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position.
abstract: A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047 (Japan).
authors.forename: Masashi
authors.initials: M
authors.lastname: Shigenobu
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047 (Japan). takena@sanken.osaka-u.ac.jp.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047 (Japan). sasai@sanken.osaka-u.ac.jp.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai
keywords: CH activation; arylation; cross-coupling; heterocycles; palladium