title: Morita-Baylis-Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation.
abstract: Lewis base-promoted annulation reactions with MBHADs have emerged as a key platform for the construction of functionalized carbo- and heterocycles. MBHADs, which are economical and readily available, exert diverse and amazing reactivity when reacted with a wide range of electrophiles. A variety of carbo- and heterocycles, most of which are predominant in natural products and pharmaceuticals, could be constructed with high efficiency. This tutorial review will describe these annulation reactions, with a special emphasis on recent work regarding diverse reactivities of MBHADs.
authors.affiliation: College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China.
authors.forename: Peizhong
authors.initials: P
authors.lastname: Xie
authors.forename: You
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D003500:Cyclization; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000438:Alcohols; D058115:Lewis Bases; D011083:Polycyclic Compounds