title: Adjunctive psychosocial intervention following Hospital discharge for Patients with bipolar disorder and comorbid substance use: A pilot randomized controlled trial.
abstract: Bipolar disorder and substance use disorders are highly debilitating conditions, and especially when co-occurring, are associated with a variety of negative outcomes. Surprisingly, there is a relative lack of research on feasible and effective psychosocial treatments for individuals with comorbid bipolar and substance use disorder (BD-SUD), and a dearth of literature examining interventions designed specifically to improve outcomes such as symptoms, functioning, and treatment engagement/adherence following psychiatric hospitalization in this population. In the current paper, we report results of a pilot randomized controlled trial (n=30), comparing the recently developed Integrated Treatment Adherence Program, which includes individual and telephone sessions provided to patients and their significant others, versus Enhanced Assessment and Monitoring for those with BD-SUD. Participants who received the Integrated Treatment Adherence Program demonstrated significantly faster and greater improvements in depression, mania, functioning, and values-consistent living than participants randomized to Enhanced Assessment and Monitoring, and there was a trend for increased treatment adherence over time. Results are discussed in light of existing literature and study limitations, and suggestions for future research are proposed.
authors.affiliation: Department of Psychology, Lafayette College, Easton, PA, USA,; Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Wenze
authors.affiliation: Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Psychosocial Research, Butler Hospital, Providence, RI, USA.
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Gaudiano
authors.affiliation: Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Psychosocial Research, Butler Hospital, Providence, RI, USA.
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Weinstock
authors.affiliation: Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Psychosocial Research, Butler Hospital, Providence, RI, USA.
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Tezanos
authors.affiliation: Department of Psychiatry & Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Psychosocial Research, Butler Hospital, Providence, RI, USA.
authors.forename: Ivan W
authors.initials: IW
authors.lastname: Miller
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D061345:Early Medical Intervention / Q000639:trends*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge / Q000639:trends*; D010865:Pilot Projects; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*
keywords: Depression; Mania; Psychiatric hospitalization; Treatment adherence; Values clarification