title: Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?
abstract: Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.
authors.affiliation: UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Roy
authors.affiliation: UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France. Electronic address: Jean-Yves.Le-Guennec@Inserm.fr.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Le Guennec
authors.affiliation: Institut des Biomolécules Max Mousseron, CNRS UMR 5247, Université de Montpellier, ENSCM, Montpellier, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Galano
authors.affiliation: UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Thireau
authors.affiliation: Institut des Biomolécules Max Mousseron, CNRS UMR 5247, Université de Montpellier, ENSCM, Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bultel-Poncé
authors.affiliation: UMR CNRS 9214, Inserm U1046, Physiologie et Médecine Expérimentale du cœur et des Muscles - PHYMEDEXP, Université de Montpellier, Montpellier, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Demion
authors.affiliation: Institut des Biomolécules Max Mousseron, CNRS UMR 5247, Université de Montpellier, ENSCM, Montpellier, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Oger
authors.affiliation: The University of Hong Kong, School of Biological Sciences, Hong Kong Special Administrative Region.
authors.forename: Jetty Chung-Yung
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Institut des Biomolécules Max Mousseron, CNRS UMR 5247, Université de Montpellier, ENSCM, Montpellier, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Durand
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000378:metabolism*; D006801:Humans; D028421:Isoprostanes / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D028421:Isoprostanes; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid
keywords: Arrhythmia; Isoprostanes; Neuroprostanes; Omega-3 PUFA; Oxidative stress