title: The search for the origin of factor VIII synthesis and its impact on therapeutic strategies for hemophilia A.
authors.affiliation: The Children's Hospital of Philadelphia, Center for Cell and Molecular Therapeutics, Perelman School of Medicine at the University of Pennsylvania, PA, USA arruda@email.chop.edu.
authors.forename: Valder R
authors.initials: VR
authors.lastname: Arruda
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000378:metabolism*; D005169:Factor VIII / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D006467:Hemophilia A / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007728:Kupffer Cells / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000378:metabolism*
chemical_list: D005169:Factor VIII