title: OS094. Subclinical left ventricular dysfunction in preeclamptic women with preserved left ventricular ejection fraction: A 2D speckle tracking imaging study.
abstract: BACKGROUND
  Patients with preeclampsia are at risk for cardiovascular disease [1,2]. Changes in cardiac function are subtle in preeclampsia and are quantitatively difficult with conventional imaging. Strain measurements using speckle-tracking echocardiography have been used to sensitively quantifyabnormalities in other disease settings [3].
  
  
  OBJECTIVE
  The objective of this study was to evaluate changes in myocardial strain using speckle tracking echocardiography in women with and without preeclampsia. We hypothesized that global left systolic strain measures would prove more sensitive than conventional left ventricular ejection fraction in detecting early changes in systolic LV function manifesting as subclinical disease prior to overt progression.
  
  
  METHODS
  We evaluated the feasibility and sensitivity of strain imaging using speckle tracking echocardiography. Thirty-six women were enrolled in this pilot study; 28 were analyzed: 11 with preeclampsia and 17 without preeclampsia. Echocardiographic Ejection fraction and global peak longitudinal ,radial and circumferential strain were measured.
  
  
  RESULTS
  Global Median longitudinal strain was significantly worsened in women with preeclampsia compared to women without preeclampsia (P<0.0001). Similar results were observed for global radial strain (P=0.006) and circumferential strain (P=0.03). There was no significant difference in ejection fraction between the groups (P=0.52) (Table 1). Data are presented as median (interquartile range).
  
  
  CONCLUSIONS
  Myocardial strain imaging using speckle tracking is more sensitive than left ventricular ejection fraction to detect differences in left ventricular systolic function in women with and without preeclampsia.
authors.affiliation: Anesthesia and Critical Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: S
authors.initials: S
authors.lastname: Shahul
authors.affiliation: Obstetrics and Gynecology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: J
authors.initials: J
authors.lastname: Rhee
authors.affiliation: Obstetrics and Gynecology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: S
authors.initials: S
authors.lastname: Rana
authors.affiliation: Obstetrics and Gynecology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: M
authors.initials: M
authors.lastname: Hacker
authors.affiliation: Anesthesia and Critical Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: J
authors.initials: J
authors.lastname: Mitchell
authors.affiliation: Anesthesia and Critical Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: P
authors.initials: P
authors.lastname: Hess
authors.affiliation: Anesthesia and Critical Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: F-U-D
authors.initials: FU
authors.lastname: Mahmood
authors.affiliation: Anesthesia and Critical Care, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, United States.
authors.forename: D
authors.initials: D
authors.lastname: Talmor