title: Nested Case-control Study of Occupational Radiation Exposure and Breast and Esophagus Cancer Risk among Medical Diagnostic X Ray Workers in Jiangsu of China.
abstract: Medical diagnostic X-ray workers are one occupational group that expose to the long-term low-dose external radiation over their working lifetime, and they may under risk of different cancers. This study aims to determine the relationship between the occupational X-ray radiation exposure and cancer risk among these workers in Jiangsu, China. We conducted Nested case-control study to investigate the occupational X-ray radiation exposure and cancer risk. Data were collected through self-administered questionnaire, which includes but not limits to demographic data, personal behaviors and family history of cancer. Retrospective dose reconstruction was conducted to estimate the cumulative doses of the x-ray workers. Inferential statistics, t-test and 2 tests were used to compare the differences between each group. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of cancer by adjusting the age, gender. All 34 breast cancer cases and 45 esophageal cancer cases that detected in a cohort conducted among health workers between 1950~2011 were included in this presented study, and 158 cancer-free controls were selected by frequency-matched (1:2). Our study found that the occupational radiation exposure was associated with a significantly increased cancer risk compared with the control, especially in breast cancer and esophageal cancer (adjusted OR=2.90, 95% CI: 1.19-7.04 for breast cancer; OR=4.19, 95% CI: 1.87-9.38 for esophageal cancer, and OR=3.43, 95% CI: 1.92-6.12 for total cancer, respectively). The occupational X-ray radiation exposure was associated with increasing cancer risk, which indicates that proper intervention and prevention strategies may be needed in order to bring down the occupational cancer risk.
authors.affiliation: Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control, Nanjing, China E-mail : wangfuru@jscdc.cn; wangfuru1983@126.com.
authors.forename: Fu-Ru
authors.initials: FR
authors.lastname: Wang
authors.forename: Qiao-Qiao
authors.initials: QQ
authors.lastname: Fang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Tang
authors.forename: Xiao-San
authors.initials: XS
authors.lastname: Xu
authors.forename: Tanmay
authors.initials: T
authors.lastname: Mahapatra
authors.forename: Sanchita
authors.initials: S
authors.lastname: Mahapatra
authors.forename: Yu-Fei
authors.initials: YF
authors.lastname: Liu
authors.forename: Ning-Le
authors.initials: NL
authors.lastname: Yu
authors.forename: Quan-Fu
authors.initials: QF
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D011379:Prognosis; D000069079:Radiation Exposure / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D014965:X-Rays / Q000009:adverse effects*; D055815:Young Adult