title: Synthesis and characterization of magnetite/silver/antibiotic nanocomposites for targeted antimicrobial therapy.
abstract: The article is devoted to preparation and characterization of magnetite/silver/antibiotic nanocomposites for targeted antimicrobial therapy. Magnetite nanopowder was produced by thermochemical technique; silver was deposited on the magnetite nanoparticles in the form of silver clusters. Magnetite/silver nanocomposite was investigated by XRD, SEM, TEM, AFM, XPS, EDX techniques. Adsorptivity of magnetite/silver nanocomposite towards seven antibiotics from five different groups was investigated. It was shown that rifampicin, doxycycline, ceftriaxone, cefotaxime and doxycycline may be attached by physical adsorption to magnetite/silver nanocomposite. Electrostatic surfaces of antibiotics were modeled and possible mechanism of antibiotic attachment is considered in this article. Raman spectra of magnetite, magnetite/silver and magnetite/silver/antibiotic were collected. It was found that it is difficult to detect the bands related to antibiotics in the magnetite/silver/antibiotic nanocomposite spectra due to their overlap by the broad carbon bands of magnetite nanopowder. Magnetic measurements revealed that magnetic saturation of the magnetite/silver/antibiotic nanocomposites decreased on 6-19 % in comparison with initial magnetite nanopowder. Pilot study of antimicrobial properties of the magnetite/silver/antibiotic nanocomposites were performed towards Bacillus pumilus.
authors.affiliation: Frantsevich Institute for Problems of Materials Science, NAS of Ukraine, Kyiv 03142, Ukraine; NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland. Electronic address: ole-na@email.ua.
authors.forename: Olena
authors.initials: O
authors.lastname: Ivashchenko
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland; Institute of Molecular Physics, Polish Academy of Sciences, 60-179 Poznan, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Lewandowski
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Peplińska
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Jarek
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Nowaczyk
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wiesner
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Karol
authors.initials: K
authors.lastname: Załęski
authors.affiliation: Frantsevich Institute for Problems of Materials Science, NAS of Ukraine, Kyiv 03142, Ukraine.
authors.forename: Tetyana
authors.initials: T
authors.lastname: Babutina
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Alicja
authors.initials: A
authors.lastname: Warowicka
authors.affiliation: NanoBioMedical Centre, Adam Mickiewicz University, 61614 Poznan, Poland; Department of Macromolecular Physics, Adam Mickiewicz University, 61614 Poznan, Poland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Jurga
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D002439:Cefotaxime / Q000737:chemistry; D004318:Doxycycline / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D056951:Photoelectron Spectroscopy; D012293:Rifampin / Q000737:chemistry; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D058185:Magnetite Nanoparticles; D012834:Silver; D004318:Doxycycline; D002439:Cefotaxime; D012293:Rifampin
keywords: Adsorptivity; Antibiotic; Magnetite nanoparticles; Nanocomposite; Silver