title: Mycobacterial Lipidomics.
abstract: Lipidomics is a distinct subspecialty of metabolomics concerned with hydrophobic molecules that organize into membranes. Most of the lipid classes present in Mycobacterium tuberculosis are found only in Actinobacteria and show extreme structural diversity. This article highlights the conceptual basis and the practical challenges associated with the mass spectrometry-based lipidomic study of M. tuberculosis to solve basic questions about the virulence of this lipid-laden organism.
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: Emilie
authors.initials: E
authors.lastname: Layre
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
authors.forename: Reem
authors.initials: R
authors.lastname: Al-Mubarak
authors.affiliation: Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523.
authors.forename: John T
authors.initials: JT
authors.lastname: Belisle
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: D
authors.initials: D
authors.lastname: Branch Moody
mesh_terms: D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis*; D013058:Mass Spectrometry; D055432:Metabolomics; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008055:Lipids