title: [Micrometastases in sentinel lymph node in endometrial cancer patients].
abstract: BACKGROUND
  Detection of micrometastases in sentinel lymph nodes (SLN) extends our knowledge of lymphatic spread in endometrial cancer, although its clinical significance has not yet been confirmed.
  
  
  OBJECTIVE
  The aim of study was to determine the incidence of SLN micrometastases and to analyze the association between micrometastases and disease relapse.
  
  
  METHODS
  Fifty-four patients with endometrioid endometrial cancer underwent routine surgical therapy and sentinel lymph node biopsy (SLNB). SLNB was performed using two techniques: cervical injection of 99mTc-labelled albumin or blue dye and fundal injection of blue dye. SLNs were subjected to ultrastaging with immunohistochemistry (AE1/AE3, 150µm).
  
  
  RESULTS
  At least one SLN was detected in 51 patients (94.4%) and bilateral SLN detection was achieved in 80.4%. Nodal macrometastases were found in 3 patients (6.3%). SLNB enabled us to detect nodal macrometastases in 2 out of those 3 patients. In the third case, detection of SLN micrometastasis allowed to correctly determine the nodal status, thus avoiding the false negative result of SLNB. In 48 patients with detected 184 SLNs, there were 4 patients (8.3%) with micrometastases and 4 (8.3%) with ITC foci. No significant associations between the presence of risk factors (grade, myometrial invasion, cervical invasion, lymphovascular space invasion) and incidence of micrometastases and/or ITC foci in SLNs were found.
  
  
  CONCLUSIONS
  Detection of micrometastases may result in lower false-negative rate, thus increasing SLNB safety.
authors.forename: Sambor
authors.initials: S
authors.lastname: Sawicki
authors.forename: Juliusz
authors.initials: J
authors.lastname: Kobierski
authors.forename: Marcin
authors.initials: M
authors.lastname: Liro
authors.forename: Szymon
authors.initials: S
authors.lastname: Wojtylak
authors.forename: Piotr
authors.initials: P
authors.lastname: Lass
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wydra
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018269:Carcinoma, Endometrioid / Q000556:secondary*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D061206:Neoplasm Micrometastasis / Q000473:pathology*; D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; D013668:Technetium Tc 99m Aggregated Albumin