title: RNA Viruses and RNAi: Quasispecies Implications for Viral Escape.
abstract: Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is applied, including host immune systems and antiviral drugs. RNA interference (RNAi) acts to inhibit protein synthesis by targeting specific mRNAs for degradation and this process has been developed to target RNA viruses, exhibiting their potential as a therapeutic against infections. However, viruses containing mutations conferring resistance to RNAi were isolated in nearly all cases, underlining the problems of rapid viral evolution. Thus, while promising, the use of RNAi in treating or preventing viral diseases remains fraught with the typical complications that result from high specificity of the target, as seen in other antiviral regimens.
authors.affiliation: Department of Medical Microbiology and Immunology, College of Medicine, The University of Toledo, 3055 Arlington Avenue, Toledo, OH 43614, USA. John.Presloid@utoledo.edu.
authors.forename: John B
authors.initials: JB
authors.lastname: Presloid
authors.affiliation: Department of Medical Microbiology and Immunology, College of Medicine, The University of Toledo, 3055 Arlington Avenue, Toledo, OH 43614, USA. Isabel.Novella@utoledo.edu.
authors.forename: Isabel S
authors.initials: IS
authors.lastname: Novella
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D024882:Drug Resistance, Viral; D019143:Evolution, Molecular; D014644:Genetic Variation; D006801:Humans; D057131:Immune Evasion; D009154:Mutation; D034622:RNA Interference; D012328:RNA Viruses / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D014779:Virus Replication
keywords: RNA virus; RNAi; adaptations; escape; quasispecies