title: Relation between ADIPOQ gene polymorphisms and type 2 diabetes in a Chinese population.
abstract: OBJECTIVE
  We aimed to investigate the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population.
  
  
  METHODS
  The present study included 510 subjects with normal glucose tolerant (NGT) and 510 patients with type 2 diabetic. Five SNPs (rs2241767, rs3821799, rs182052, rs1501299 and rs7627128) were genotyped by TaqMan methods.
  
  
  RESULTS
  Of these 5 SNPs, three SNPs (rs1501299, rs182052, and rs7627128) were found to be significantly associated with T2DM. The haplotypes AAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in T2DM patients (OR=2.051, 95% CI: 1.439~2.923, P<0.001), but GAT (Construction of rs1501299, rs182052, and rs7627128) was frequent in the control group (OR=0.65, 95% CI: 0.540~0.805, P<0.001).
  
  
  CONCLUSIONS
  The ADIPOQ gene variants and haplotype were associated with the risk for development of type 2 diabetes.
authors.affiliation: 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin 300070, China.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Tianjin Medical University Tianjin 300070, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.affiliation: 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin 300070, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Xie
authors.affiliation: 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, The Key Laboratory of Hormones and Development (Ministry of Health), Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin 300070, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Li
keywords: ADIPOQ; case-control study; diabetes; genetic polymorphism