title: Three-Component Functionalized Dihydropyridine Synthesis via a Formal Inverse Electron-Demand Hetero-Diels-Alder Reaction.
abstract: A mild three-component synthetic approach to versatile 2-amino-1,4-dihydropyridines from terminal alkynes, sulfonyl azides, and N-sulfonyl-1-aza-1,3-butadienes was successfully developed and relied on the in situ generation of metalated ynamide intermediates Ib to achieve a formal inverse electron-demand hetero-Diels-Alder reaction. Experimental results suggest that alkali metal cations (Li(+) and Cs(+) ions) might play a critical role to achieve the cycloaddition process.
authors.affiliation: Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Ling
authors.affiliation: Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ma