title: An Au(I)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole.
abstract: An Au(I)-catalyzed tandem reaction for the synthesis of 2-phenyl-1,4,5,6-tetrahydrocyclopenta[b]pyrrole derivatives from 1-(1-hydroxy-3-phenylprop-2-yn-1-yl)cyclobutanol and primary amines or NH4OAc has been developed to afford a series of polysubstituted pyrroles in moderate to good yields.
authors.affiliation: School of Pharmacy & State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, P. R. China. wangshh@lzu.edu.cn.
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Mou
authors.forename: Zheng-Liang
authors.initials: ZL
authors.lastname: Xu
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Dao-Yong
authors.initials: DY
authors.lastname: Zhu
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Wen
authors.initials: W
authors.lastname: Bao
authors.forename: Shi-Jiang
authors.initials: SJ
authors.lastname: Zhou
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C568058:1,4,5,6-tetrahydrocyclopenta(b)pyrrole; D000588:Amines; D003503:Cyclobutanes; D003517:Cyclopentanes; D011758:Pyrroles; C538814:cyclobutanol; D006046:Gold