title: Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense.
abstract: Investigation of a DCM extract of the bark of Pleiogynium timoriense from the former Merck collection of natural product extracts for antiproliferative activity indicated that it was active with an IC50 value of 1.3 μg/mL against the A2780 ovarian cancer cell line. Bioassay-directed fractionation of this extract yielded the three new bioactive trihydroxyalkylcyclohexenones 1-3. Their structures were determined by a combination of spectroscopic and chemical methods. Compounds 1-3 exhibited submicromolar antiproliferative activity against the A2780 human ovarian cancer cell line, with IC50 values of 0.8, 0.7, and 0.8 μM, respectively.
authors.affiliation: †Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Eaton
authors.affiliation: ‡Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States.
authors.forename: L Harinantenaina
authors.initials: LH
authors.lastname: Rakotondraibe
authors.affiliation: †Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
authors.forename: Peggy J
authors.initials: PJ
authors.lastname: Brodie
authors.affiliation: §Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Goetz
authors.affiliation: †Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States.
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003512:Cyclohexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D014058:Tonga
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones