title: Endovascular treatment of bifurcation intracranial aneurysms with the WEB SL/SLS: 6-month clinical and angiographic results.
abstract: BACKGROUND
  The WEB device is a recent intrasaccular flow disruption technique developed for the treatment of wide-necked intracranial aneurysms. To date, a single report on the WEB Single-Layer (SL) treatment of intracranial aneurysms has been published with 1-months' safety results. The aim of this study is to report our experience and 6-month clinical and angiographic follow-up of endovascular treatment of wide-neck aneurysm with the WEB SL.
  
  
  METHODS
  Ten patients with 10 unruptured wide-necked aneurysms were prospectively enrolled in this study. Feasibility, intraoperative and postoperative complications, and outcomes were recorded. Immediate and 6-month clinical and angiographic results were evaluated.
  
  
  RESULTS
  Failure of WEB SL placement occurred in two cases. Eight aneurysms were successfully treated using one WEB SL without additional treatment. Three middle cerebral artery, four anterior communicating artery, and one basilar artery aneurysms were treated. Average dome width was 7.5 mm (range 5.4-10.7 mm), and average neck size was 4.9 mm (range 2.6-6.5 mm). No periprocedural complication was observed, and morbi-mortality at discharge and 6 months was 0.0%. Angiographic follow-up at 6 months demonstrated complete aneurysm occlusion in 2/8 aneurysms, neck remnant in 5/8 aneurysms, and aneurysm remnant in 1/8 aneurysm.
  
  
  CONCLUSIONS
  From this preliminary study, treatment of bifurcation intracranial aneurysms using WEB SL is feasible. WEB SL treatment seems safe at 6 months; however, the rate of neck remnants is not negligible due to compression of the WEB SL. Further technical improvements may be needed in order to ameliorate the occlusion in the WEB SL treatment.
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bozzetto Ambrosi
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France benjamin.gory@chu-lyon.fr.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gory
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Rotem
authors.initials: R
authors.lastname: Sivan-Hoffmann
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Roberto
authors.initials: R
authors.lastname: Riva
authors.affiliation: Department of Neurosurgery, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Francesco
authors.initials: F
authors.lastname: Signorelli
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Paul-Emile
authors.initials: PE
authors.lastname: Labeyrie
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Islam
authors.initials: I
authors.lastname: Eldesouky
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Udi
authors.initials: U
authors.lastname: Sadeh-Gonike
authors.affiliation: Department of Pharmacy, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Armoiry
authors.affiliation: Department of Interventional Neuroradiology, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Turjman
mesh_terms: D000328:Adult; D000368:Aged; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging / Q000601:surgery; D001488:Basilar Artery / Q000000981:diagnostic imaging / Q000601:surgery; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000601:surgery*; D007431:Intraoperative Complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome
keywords: Intracranial aneurysms; WEB device; endovascular treatment; outcome