title: Diagnostic Accuracy of CT-Guided Transthoracic Needle Biopsy for Solitary Pulmonary Nodules.
abstract: To evaluate the diagnostic accuracy of computed tomography (CT)-guided percutaneous lung biopsy for solitary pulmonary nodules. Three hundred and eleven patients (211 males and 100 females), with a mean age of 59.6 years (range, 19-87 years), who were diagnosed with solitary pulmonary nodules and underwent CT-guided percutaneous transthoracic needle biopsy between January 2008 and January 2014 were reviewed. All patients were confirmed by surgery or the clinical course. The overall diagnostic accuracy and incidence of complications were calculated, and the factors influencing these were statistically evaluated and compared. Specimens were successfully obtained from all 311 patients. A total of 217 and 94 cases were found to be malignant and benign lesions, respectively, by biopsy. Two hundred and twenty-five (72.3%) carcinomas, 78 (25.1%) benign lesions, and 8 (2.6%) inconclusive lesions were confirmed by surgery and the clinical course. The diagnostic accuracy, sensitivity, and specificity of CT-guided percutaneous transthoracic needle biopsy were 92.9%, 95.3%, and 95.7%, respectively. The incidences of pneumothorax and self-limiting bleeding were 17.7% and 11.6%, respectively. Taking account of all evidence, CT-guided percutaneous lung biopsy for solitary pulmonary nodules is an efficient, and safe diagnostic method associated with few complications.
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Wenkui
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Yao
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Tangfeng
authors.initials: T
authors.lastname: Lv
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Liang
authors.affiliation: Department of pathology, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D003951:Diagnostic Errors; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D061705:Image-Guided Biopsy / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D008175:Lung Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000209:etiology; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult