title: [77-year-old female with hyponatremia, pruritus and papulous exanthema].
abstract: METHODS
  A 77 year old female patient was admitted for the evaluation of hyponatremia and a generalized papulous exanthema with severe pruritus.
  
  
  METHODS
  The syndrome of inappropriate antidiuretic hormone secretion (SIADH) could be diagnosed as cause for hyponatremia. Biopsy of a soft tissue tumor revealed a T-cell lymphoma with widespread skelettal dissemination.
  
  
  METHODS
  Chemotherapy caused a rapid response and improvement of general well-being. SIADH could be controlled by the specific vasopressin-2-receptor antagonist tolvaptan.
  
  
  CONCLUSIONS
  In this patient, both the papulous exanthema and the SIADH are regarded as T-cell-lymphoma-associated paraneoplastic syndromes.
authors.affiliation: Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Judith
authors.initials: J
authors.lastname: Brock
authors.affiliation: Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Thomas
authors.initials: T
authors.lastname: Karrasch
authors.forename: Fritz Christian
authors.initials: FC
authors.lastname: Roller
authors.affiliation: Institut für Radiologie, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Ferdinand Fritz
authors.initials: FF
authors.lastname: Roller
authors.affiliation: Institut für Nuklearmedizin, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Steiner
authors.affiliation: Dermatohistologisches Labor Gießen.
authors.forename: Martin
authors.initials: M
authors.lastname: Nilles
authors.affiliation: Klinik und Poliklinik für Innere Medizin IV, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Blau
authors.affiliation: Institut für Pathologie, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Stefan
authors.initials: S
authors.lastname: Gattenlöhner
authors.affiliation: Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schäffler
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001552:Benzazepines / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018450:Disease Progression; D005076:Exanthema / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy; D064847:Multimodal Imaging; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology*; D000077602:Tolvaptan; D014057:Tomography, X-Ray Computed
chemical_list: D001552:Benzazepines; D000077602:Tolvaptan