title: PP084. Hypertension after preeclampsia in women with C1114G polymorphism in rgs2 (the regulator of g protein signaling 2).
abstract: BACKGROUND
  Women with preeclampsia have increased risk of developing hypertension later in life. We recently demonstrated an association between preeclampsia and the CG or GG genotype of the rs4606 in the regulator of G protein signaling 2 (RGS2) gene. RGS2 negatively regulates several vasoconstrictors.
  
  
  OBJECTIVE
  To explore the potential association between the rs4606 and hypertension after pregnancy in women with previous preeclampsia or controls.
  
  
  METHODS
  DNA from 933 women with a history of preeclampsia and 2010 women without a history of preeclampsia was analyzed for the rs4606 in RGS2.
  
  
  RESULTS
  Preeclampsia, but not the rs4606, was significantly associated with hypertension (systolic blood pressure ⩾140mmHg and/or diastolic blood pressure ⩾90mmHg and/or taking antihypertensive drugs) in both univariate and multivariate analyses, including adjustment for classical cardiovascular risk factors. For women with hypertension defined as blood pressure above 160/100mmHg and/or taking antihypertensive drugs, the rs4606 was significantly associated with hypertension in multivariate analysis. Our data further suggested an association between the rs4606 and physical activity in relation to hypertension.
  
  
  CONCLUSIONS
  Women with the rs4606 CG or GG genotype may be at elevated risk for severe hypertension. However, a history of preeclampsia remained an independent predictor of hypertension after accounting for this polymorphism and classical cardiovascular risk factors.
authors.forename: Anne Stine
authors.initials: AS
authors.lastname: Kvehaugen
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Melien
authors.forename: Oddgeir Lingaas
authors.initials: OL
authors.lastname: Holmen
authors.forename: Hannele
authors.initials: H
authors.lastname: Laivuori
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff