title: Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?
authors.affiliation: 1 Senior Advisor to the Director, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland.
authors.forename: Sitta
authors.initials: S
authors.lastname: Sittampalam
authors.affiliation: 2 Vice President and General Manager, Corning Life Sciences , Tewksbury, Massachusetts.
authors.forename: Richard
authors.initials: R
authors.lastname: Eglen
authors.affiliation: 3 Chemist, Molecular Toxicology and Informatics Group, Biomolecular Screening, National Institute of Environmental Science, National Institutes of Health , Research Triangle Park, North Carolina.
authors.forename: Stephen
authors.initials: S
authors.lastname: Ferguson
authors.affiliation: 4 Director of Research, Anesthesia and Pain Medicine/Staff Anesthesiologist, Hospital for Sick Children, University of Toronto , Toronto, Ontario, Canada .
authors.forename: Jason Thomas
authors.initials: JT
authors.lastname: Maynes
authors.affiliation: 5 Director, National Center for Environmental Assessment , Environmental Protection Agency, Arlington, Virginia.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Olden
authors.affiliation: 6 CEO , 3D Biomatrix, Ann Arbor, Michigan.
authors.forename: Laura
authors.initials: L
authors.lastname: Schrader
authors.affiliation: 7 Research Fellow, Avery Group, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland, Australia .
authors.forename: Todd
authors.initials: T
authors.lastname: Shelper
authors.affiliation: 8 Leader, Biomolecular Screening and Probe Development, Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland.
authors.forename: Marc
authors.initials: M
authors.lastname: Ferrer
mesh_terms: D001681:Biological Assay / Q000379:methods / Q000639:trends; D018929:Cell Culture Techniques / Q000379:methods* / Q000639:trends; D005544:Forecasting; D006126:Group Processes; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends