title: Cyprinid Herpesvirus 3: An Archetype of Fish Alloherpesviruses.
abstract: The order Herpesvirales encompasses viruses that share structural, genetic, and biological properties. However, members of this order infect hosts ranging from molluscs to humans. It is currently divided into three phylogenetically related families. The Alloherpesviridae family contains viruses infecting fish and amphibians. There are 12 alloherpesviruses described to date, 10 of which infect fish. Over the last decade, cyprinid herpesvirus 3 (CyHV-3) infecting common and koi carp has emerged as the archetype of fish alloherpesviruses. Since its first description in the late 1990s, this virus has induced important economic losses in common and koi carp worldwide. It has also had negative environmental implications by affecting wild carp populations. These negative impacts and the importance of the host species have stimulated studies aimed at developing diagnostic and prophylactic tools. Unexpectedly, the data generated by these applied studies have stimulated interest in CyHV-3 as a model for fundamental research. This review intends to provide a complete overview of the knowledge currently available on CyHV-3.
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Maxime
authors.initials: M
authors.lastname: Boutier
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Maygane
authors.initials: M
authors.lastname: Ronsmans
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Rakus
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Joanna
authors.initials: J
authors.lastname: Jazowiecka-Rakus
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vancsok
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Léa
authors.initials: L
authors.lastname: Morvan
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
authors.forename: Ma Michelle D
authors.initials: MM
authors.lastname: Peñaranda
authors.affiliation: The Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Weymouth, Dorset, United Kingdom.
authors.forename: David M
authors.initials: DM
authors.lastname: Stone
authors.affiliation: The Centre for Environment, Fisheries and Aquaculture Science, Weymouth Laboratory, Weymouth, Dorset, United Kingdom.
authors.forename: Keith
authors.initials: K
authors.lastname: Way
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: van Beurden
authors.affiliation: MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Davison
authors.affiliation: Immunology-Vaccinology (B43b), Department of Infectious and Parasitic Diseases, Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. Electronic address: a.vdplasschen@ulg.ac.be.
authors.forename: Alain
authors.initials: A
authors.lastname: Vanderplasschen
mesh_terms: D000818:Animals; D002347:Carps; D005393:Fish Diseases / Q000821:virology*; D006564:Herpesviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D006566:Herpesviridae Infections / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny
keywords: Alloherpesviridae; Common carp; CyHV-3; Cyprinid herpesvirus 3; Fish alloherpesviruses; Herpesvirales; KHV; Koi herpesvirus