title: MicroRNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum.
abstract: MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington's disease mouse models and patients is decreased. However, the effects of microRNA-124 on the progression of Huntington's disease have not been reported. Results from this study showed that microRNA-124 increased the latency to fall for each R6/2 Huntington's disease transgenic mouse in the rotarod test. 5-Bromo-2'-deoxyuridine (BrdU) staining of the striatum shows an increase in neurogenesis. In addition, brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased. These findings suggest that microRNA-124 slows down the progression of Huntington's disease possibly through its important role in neuronal differentiation and survival.
authors.affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Wooseok
authors.initials: W
authors.lastname: Im
authors.affiliation: Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea ; Department of Biochemistry, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
authors.affiliation: Department of Neurology, Biomedical Research Institute, Seoul National University Hospital, Seoul, South Korea ; Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea.
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
keywords: Huntington's disease; SRY-related HMG box transcription factor 9; brain-derived neurotrophic factor; peroxisome; microRNA-124; mutant huntingtin; nerve regeneration; neurogenesis; neuronal survival; proliferator-activated receptor gamma coactivator 1-alpha