title: Comparison of antibacterial effects between antimicrobial peptide and bacteriocins isolated from Lactobacillus plantarum on three common pathogenic bacteria.
abstract: New strategies for the prevention or treatment of infections are required. The purpose of this study is to evaluate the effects of antimicrobial peptides and bacteriocins isolated from Lactobacillus plantarum on growth and biofilm formation of three common pathogenic microbes. The antibacterial properties of the antimicrobial peptide Tet213 and bacteriocins were tested by the disc diffusion method. Tet213 and bacteriocins showed inhibitory effects on biofilm formation for the three organisms, as observed by fluorescence microscopy. Furthermore, Tet213 and the bacteriocins all showed antimicrobial activity against the three bacterial species, with Tet213 having a greater inhibitory effect on S. aureus than the bacteriocins (P < 0.05), while the bacteriocins showed stronger antimicrobial activity against S. sanguis (P < 0.05).
authors.affiliation: Department of Infection, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital Changzhou 213003, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Ming
authors.affiliation: Department of Respiratory, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital Changzhou 213003, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Infection Control Section, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital Changzhou 213003, China.
authors.forename: Le
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Respiratory, The First Affiliated Hospital of Suzhou University Suzhou 215000, China.
authors.forename: Jian-An
authors.initials: JA
authors.lastname: Huang
keywords: Antimicrobial activity; antimicrobial peptide; bacteriocin; biofilm