title: Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders.
abstract: Stress responses entail neuroendocrine, autonomic, and behavioral changes to promote effective coping with real or perceived threats to one's safety. While these responses are critical for the survival of the individual, adverse effects of repeated exposure to stress are widely known to have deleterious effects on health. Thus, a considerable effort in the search for treatments to stress-related CNS disorders necessitates unraveling the brain mechanisms responsible for adaptation under acute conditions and their perturbations following chronic stress exposure. This paper is based upon a symposium from the 2014 International Behavioral Neuroscience Meeting, summarizing some recent advances in understanding the effects of stress on adaptive and maladaptive responses subserved by limbic forebrain networks. An important theme highlighted in this review is that the same networks mediating neuroendocrine, autonomic, and behavioral processes during adaptive coping also comprise targets of the effects of repeated stress exposure in the development of maladaptive states. Where possible, reference is made to the similarity of neurobiological substrates and effects observed following repeated exposure to stress in laboratory animals and the clinical features of stress-related disorders in humans.
authors.affiliation: Department of Psychological and Brain Sciences and Interdisciplinary Neuroscience Program, University of Iowa, IA, United States.
authors.forename: Jason
authors.initials: J
authors.lastname: Radley
authors.affiliation: Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, United States.
authors.forename: David
authors.initials: D
authors.lastname: Morilak
authors.affiliation: Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Victor
authors.initials: V
authors.lastname: Viau
authors.affiliation: Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, United States. Electronic address: serge.campeau@colorado.edu.
authors.forename: Serge
authors.initials: S
authors.lastname: Campeau
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D006801:Humans; D013312:Stress, Physiological / Q000502:physiology*; D013315:Stress, Psychological / Q000473:pathology*
keywords: Amygdala; Chronic stress; Gonadal hormones; Hippocampus; Plasticity; Prefrontal cortex; Stress habituation