title: Anthropometric Risk Factors for Differentiated Thyroid Cancer in Young Men and Women From Eastern France: A Case-Control Study.
abstract: The incidence of thyroid cancer has risen over the past decade, along with a rise in obesity. We studied the role of anthropometric risk factors for differentiated thyroid cancer at the time of diagnosis and at age 20 years in a case-control study conducted in eastern France between 2005 and 2010. The study included 761 adults diagnosed with differentiated thyroid cancer before 35 years of age between 2002 and 2006. They were matched with 825 controls from the general population. Odds ratios were calculated using conditional logistic regression models and were reported for all participants, those with papillary cancer only, and women only. The risk of thyroid cancer was higher for participants with a high body surface area (BSA), great height, or excess weight and for women with a high body fat percentage. Conversely, no significant association was found between body mass index and the risk of thyroid cancer. In the present study, we provide further evidence of the role of BSA and excess weight in the risk of thyroid cancer. These epidemiologic observations should be confirmed by further exploration of the biological mechanisms responsible for the associations of obesity and BSA with thyroid cancer.
authors.forename: Constance
authors.initials: C
authors.lastname: Xhaard
authors.forename: Florent
authors.initials: F
authors.lastname: de Vathaire
authors.forename: Enora
authors.initials: E
authors.lastname: Cléro
authors.forename: Stéphane
authors.initials: S
authors.lastname: Maillard
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.forename: Françoise
authors.initials: F
authors.lastname: Borson-Chazot
authors.forename: Geneviève
authors.initials: G
authors.lastname: Sassolas
authors.forename: Claire
authors.initials: C
authors.lastname: Schvartz
authors.forename: Marc
authors.initials: M
authors.lastname: Colonna
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lacour
authors.forename: Arlette
authors.initials: A
authors.lastname: Danzon
authors.forename: Michel
authors.initials: M
authors.lastname: Velten
authors.forename: Emilie
authors.initials: E
authors.lastname: Marrer
authors.forename: Laurent
authors.initials: L
authors.lastname: Bailly
authors.forename: Eugènia Mariné
authors.initials: EM
authors.lastname: Barjoan
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
authors.forename: Jacques
authors.initials: J
authors.lastname: Orgiazzi
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Adjadj
authors.forename: Carole
authors.initials: C
authors.lastname: Rubino
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000453:epidemiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000886:Anthropometry; D015992:Body Mass Index; D016022:Case-Control Studies; D002454:Cell Differentiation; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology*; D016017:Odds Ratio; D012307:Risk Factors; D017678:Sex Distribution; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult
keywords: anthropometric risk factors; body surface area; case-control study; obesity; thyroid cancer