title: Correlation between Gastric Mucosal Morphologic Patterns and Histopathological Severity of Helicobacter pylori Associated Gastritis Using Conventional Narrow Band Imaging Gastroscopy.
abstract: OBJECTIVE
  Identifying specific gastric mucosal morphologic patterns useful for detecting Helicobacter pylori associated gastritis and correlation with histopathological severity.
  
  
  METHODS
  The endoscopists classified the C-NBI gastroscopic findings into 5 gastric mucosal morphologic patterns as follows: type 1: regular arrangement of collecting venules, type 2: cone-shaped gastric pits, type 3: rod-shaped gastric pits with prominent sulci, type 4: ground glass-like morphology, and type 5: dark brown patches with bluish margin and irregular border. Biopsies of all of the cases were then evaluated by 5 pathologists for definitive Helicobacter pylori diagnosis.
  
  
  RESULTS
  Type 1 and type 2 patterns were statistically significant in predicting Helicobacter pylori negative status (58/60, P < 0.01). Type 3, type 4, and type 5 patterns were statistically significant in predicting Helicobacter pylori positive status (132/140, P < 0.01). Furthermore, the sensitivity, specificity, and positive and negative predictive values of type 3, 4, or 5 morphologies for predicting Helicobacter pylori positive were 94.28%, 96.66%, 98.50%, and 87.87%, respectively, correlated well with inflammation grading according to the Sydney classification (P < 0.01).
  
  
  CONCLUSIONS
  Our study suggests that gastric mucosal morphologic patterns in the Helicobacter pylori infected gastric mucosa can be reliably identified using C-NBI gastroscopy with good correlation with inflammation grading.
authors.affiliation: Endoscopic Unit, Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand ; Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand.
authors.forename: Taweesak
authors.initials: T
authors.lastname: Tongtawee
authors.affiliation: Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand ; Department of Family Medicine and Community Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
authors.forename: Soraya
authors.initials: S
authors.lastname: Kaewpitoon
authors.affiliation: Parasitic Disease Research Unit, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand ; Faculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima 30000, Thailand.
authors.forename: Natthawut
authors.initials: N
authors.lastname: Kaewpitoon
authors.affiliation: Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand ; Department of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
authors.forename: Chavaboon
authors.initials: C
authors.lastname: Dechsukhum
authors.affiliation: Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand ; Department of Family Medicine and Community Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Loyd
authors.affiliation: Endoscopic Unit, Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand ; Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand.
authors.forename: Likit
authors.initials: L
authors.lastname: Matrakool
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology*; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*; D013274:Stomach Neoplasms / Q000382:microbiology / Q000503:physiopathology