title: Infectious disease screening among stem cell transplant donors: An Institutional experience in Saudi Arabia.
abstract: BACKGROUND
  Hematopoietic stem cell transplantation (HSCT) involves the infusion of hematopoietic stem cells from a suitable donor to a patient who has undergone chemotherapy. Stem Cell transplantation is used for the treatment for a wide variety of diseases, including leukemia and lymphoma.
  
  
  OBJECTIVE
  This study highlights prevention strategies of infectious diseases among HSCT donors and recipients in our institute as guided by International guidelines. We aim to highlight the strategy for extensive screening of HIV, Hepatitis B and C, CMV infection and syphilis cases in all the stem cell units stored in our facility.
  
  
  METHODS
  We searched the institutional database to identify cases of infectious diseases among HSC transplants. Extensive donor evaluation was conducted through screening and laboratory infectious disease testing for HIV, Hepatitis B and C, CMV infection and syphilis.
  
  
  RESULTS
  Between 1996 and 2014, 263 consecutive adult HSCT were performed. An approximate equal number of autologous and allogeneic HSC collections were undertaken. The median age for autologous donors was 35 years, whereas that of allogeneic donors is 25 years. Of the 263 stem cell donors, we found 18 patients (autologous) and 2 donors (allogeneic) to be infected. We did not find any of the donors infected with HIV by the serology as well as the NAT testing protocol.
  
  
  CONCLUSIONS
  Donor screening and testing is the most critical parameter in stem cell transplantation in order to ensure the safety of the product to be transplanted. Modifications in the regulations related to donor screening are aimed at providing safe transplantation and negate the risk of accidental infection of the donor.
authors.affiliation: Department of Central Military Laboratory and Blood Bank, Hematology and Blood Bank Division;
authors.forename: Omar
authors.initials: O
authors.lastname: Alsuhaibani
authors.affiliation: Department of Central Military Laboratory and Blood Bank, Hematology and Blood Bank Division;
authors.forename: Winston Costa
authors.initials: WC
authors.lastname: Pereira
authors.affiliation: Department of Central Military Laboratory and Blood Bank, Hematology and Blood Bank Division;
authors.forename: Mohammed
authors.initials: M
authors.lastname: Tareeqanwar
authors.affiliation: Microbiology Division;
authors.forename: Nora El
authors.initials: NE
authors.lastname: Khizzi
authors.affiliation: Microbiology Division;
authors.forename: Saadia
authors.initials: S
authors.lastname: Bakheswain
authors.affiliation: Department of Central Military Laboratory and Blood Bank, Hematology and Blood Bank Division;
authors.forename: Amira
authors.initials: A
authors.lastname: Shaker
authors.affiliation: Department of Central Military Laboratory and Blood Bank, Hematology and Blood Bank Division; ; Prince Sultan Military Medical City, Riyadh, Saudi Arabia and Department of Hematology, Theodor Bilharz Research Institute, Giza, EGYPT.
authors.forename: Ghaleb
authors.initials: G
authors.lastname: Elyamany
keywords: Donors; HSCT; Hepatitis; Recipients; Screening