title: Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock.
abstract: OBJECTIVE
  To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock.
  
  
  METHODS
  Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated.
  
  
  RESULTS
  During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 ± 34% of daily time). Physical inactivity was partially reduced 3 months after (58 ± 20% of daily time). However, the time patients spent walking was only 63% of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 ± 0.3 vs 2.5 ± 0.4 m/s(2)). At hospital discharge, muscle strength and exercise capacity were approximately 54% of the predicted value, and these parameters showed significant increase in patients 3 months after (70% of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge.
  
  
  CONCLUSIONS
  Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge.
authors.affiliation: University Hospital, University of São Paulo, Rua Trajano Reis 777 apto 34 C1, São Paulo, SP, CEP 05541030, Brazil, rodrigounopar@yahoo.com.br.
authors.forename: Rodrigo Cerqueira
authors.initials: RC
authors.lastname: Borges
authors.forename: Celso R F
authors.initials: CR
authors.lastname: Carvalho
authors.forename: Alexandra Siqueira
authors.initials: AS
authors.lastname: Colombo
authors.forename: Mariucha Pereira
authors.initials: MP
authors.lastname: da Silva Borges
authors.forename: Francisco Garcia
authors.initials: FG
authors.lastname: Soriano
mesh_terms: D061725:Accelerometry; D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D053580:Muscle Strength / Q000502:physiology*; D011446:Prospective Studies; D020127:Recovery of Function; D018805:Sepsis / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology*