title: Antibodies as a source of anti-infective peptides: an update.
abstract: This review focuses on antibodies (Abs) and their function in immune protection, with particular emphasis on microbicidal Abs. Some aspects of Abs and Ab-drug conjugates as targeting therapeutic agents are also discussed. The main aim, however, is devoted to Ab-derived peptides modulating functions of the immune system and to the latest experimental evidence of Abs as a source of anti-infective and antitumor peptides derived from their complementarity determining regions and constant regions.
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Walter
authors.initials: W
authors.lastname: Magliani
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Giovati
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Tecla
authors.initials: T
authors.lastname: Ciociola
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Sperindè
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Santinoli
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Conti
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Conti
authors.affiliation: Department of Biomedical, Biotechnological & Translational Sciences, Microbiology & Virology Unit, University of Parma, 43125 Parma, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Polonelli
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D000906:Antibodies / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000276:immunology / Q000302:isolation & purification; D022801:Complementarity Determining Regions; D006801:Humans; D007239:Infections / Q000188:drug therapy*; D058990:Molecular Targeted Therapy; D010455:Peptides / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000906:Antibodies; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D022801:Complementarity Determining Regions; D010455:Peptides
keywords: antibodies; antibody-derived anti-infective peptides; antibody-derived antitumor peptides; antibody-derived immunomodulatory peptides; cryptides; microbicidal antibodies; therapeutic antibodies