title: A Novel Restraining Device for Small Animal Imaging Exams: Validation in Rabbits.
abstract: OBJECTIVE
  To develop, validate, and patent a Restraining Device for Small Animal Imaging Exams (RDSAIE) that allows exams to be comfortably conducted without risks to animals and professionals.
  
  
  METHODS
  A RDSAIE with a mobile cover and shelf was built with transparent acrylic material. A total of six anesthetized rabbits were used to perform the following imaging exams of the skull: Cone Beam Computed Tomography, Magnetic Resonance Imaging, and Scintigraphy.
  
  
  RESULTS
  The device showed great functionality and full visibility of the animal behavior, which remained fully stabilized and immobilized in either the horizontal or vertical position without the need for a person to remain in the test room to assist them. The procedures were performed without difficulty, and images of good resolution and without artifacts were obtained.
  
  
  CONCLUSIONS
  The RDSAIE is comfortable, safe, efficient, and ergonomic. It allows the easy placement of animals in different body positions, including the vertical, the maintenance of postural stability, and full visibility. It may be constructed for animals heavier than 4 kg and it is adaptable for translational studies in anima nobile.
authors.affiliation: Center of Experimental Surgery, Department of Surgery, School of Medicine, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil ; Orofacial Pain and Masticatory Dysfunction Clinic, Department of Dental Clinic, School of Dentistry, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Carlos Henrique
authors.initials: CH
authors.lastname: Barbosa
authors.affiliation: Department of Radiology, School of Medicine, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Carvalho
authors.affiliation: Department of Radiology, School of Medicine, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Souza
authors.affiliation: Orofacial Pain and Masticatory Dysfunction Clinic, Department of Dental Clinic, School of Dentistry, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Machado
authors.affiliation: Department of Pathology and Oral Diagnosis, Dental School, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: Fábio
authors.initials: F
authors.lastname: Guedes
authors.affiliation: Orofacial Pain and Masticatory Dysfunction Clinic, Department of Dental Clinic, School of Dentistry, Federal University of Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Monteiro
authors.affiliation: Center of Experimental Surgery, Department of Surgery, School of Medicine, Federal University of Rio de Janeiro, 21941-913 Rio de Janeiro, RJ, Brazil.
authors.forename: Alberto
authors.initials: A
authors.lastname: Schanaider
mesh_terms: D000818:Animals; D054893:Cone-Beam Computed Tomography / Q000295:instrumentation*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D019047:Phantoms, Imaging; D011817:Rabbits; D012886:Skull / Q000000981:diagnostic imaging*