title: Sclerosed Hemangioma Accompanied by Multiple Cavernous Hemangiomas of the Liver.
abstract: BACKGROUND
  A sclerosed hemangioma of the liver, an extremely rare type of benign hepatic tumor, was found at autopsy.
  
  
  METHODS
  An 81-year-old Japanese man was admitted to our hospital for surgical resection of squamous cell carcinoma of the skin in his left forearm. At admission, serological tests for hepatitis B surface antigen and hepatitis C antibody were negative with no evidence of cirrhosis. At 2, 3, and 5 months after the removal of the forearm tumor, skin grafting was performed because of unhealed skin ulceration. Although anti-bacterial drugs were prescribed, the patient died after the 3rd skin graft (5 months after the surgery) because of pneumonia. During the treatment course, the patient was diagnosed as having multiple liver masses suspected to be cysts of the liver based on non-contrasted computed tomography results. Autopsy revealed a sclerosed hemangioma occupying the entire left lobe accompanied by multiple small cavernous hemangiomas in the right lobe of the liver.
  
  
  CONCLUSIONS
  Sclerosed hemangioma, a rare benign disease, occurred in association with degeneration and sclerosis of cavernous hemangiomas of the liver. The VEGF pathway may be involved in the genesis of cavernous and sclerosed hemangioma of the liver.
authors.affiliation: Department of Pathology II, Kansai Medical University, hirakata, Osaka, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Yuki
authors.affiliation: Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Emoto
authors.affiliation: Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yoshizawa
authors.affiliation: Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuri
authors.affiliation: Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
mesh_terms: D000369:Aged, 80 and over; D001706:Biopsy; D003937:Diagnosis, Differential; D006392:Hemangioma, Cavernous / Q000175:diagnosis* / Q000601:surgery; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D014057:Tomography, X-Ray Computed