title: Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer.
abstract: BACKGROUND
  Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. The high frequency of positive families shows the importance of public awareness and screening strategies in those families. Cancer/testis (CT) antigens such as Aurora-C and Survivin are a group of antigens expressed in various tumor types of human cancers. Therefore, the aim of this study was to investigate the expression of Aurora-C and Survivin genes in malignant and normal tissues and their correlation to clinicopathological characteristics.
  
  
  METHODS
  Tumor samples were obtained from 33 patients and adjacent non-tumorous tissues from 7 patients were also used as control. Patients were diagnosed with various stages of colorectal cancer. The level of Aurora-C and Survivin genes were evaluated by using real-time quantitative Polymerase Chain Reaction.
  
  
  RESULTS
  The expression pattern of Survivin and Aurora-C revealed significant changes in tumor tissues when compared with normal tissues (p < 0.05). Also, these expressions were associated with the grade of disease and tumor size. There was no significant relationship between the expression of Survivin and Aurora-C genes (p > 0.05).
  
  
  CONCLUSIONS
  In conclusion, the overexpression of Aurora-C and Survivin genes may play an important role in the development of colorectal cancer and may play a potential role in cancer therapy.
authors.forename: Saba
authors.initials: S
authors.lastname: Hosseini
authors.forename: Shahryar
authors.initials: S
authors.lastname: Hashemzadeh
authors.forename: Mehrdad Asghari
authors.initials: MA
authors.lastname: Estiar
authors.forename: Reza
authors.initials: R
authors.lastname: Ebrahimzadeh
authors.forename: Mohammad Bassir Abolghassemi
authors.initials: MB
authors.lastname: Fakhree
authors.forename: Bahman
authors.initials: B
authors.lastname: Yousefi
authors.forename: Sara
authors.initials: S
authors.lastname: Sheikholeslami
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Modarresi
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Sakhinia
mesh_terms: D000328:Adult; D000368:Aged; D064108:Aurora Kinase C / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; D064108:Aurora Kinase C