title: Visual Prognosis and Ocular Complications in Herpetic versus HLA-B27- or Ankylosing Spondylitis-associated Anterior Uveitis.
abstract: OBJECTIVE
  To investigate the visual prognosis and ocular complications in patients with herpetic versus HLA-B27 associated anterior uveitis (AU).
  
  
  METHODS
  This was a retrospective, observational study conducted at the ophthalmology department of the University Medical Center of Groningen. Sixty-two herpetic and 113 HLA-B27-associated AU patients were included. The main outcome measures were visual acuity and ocular complications.
  
  
  RESULTS
  Visual acuity over time was significantly lower in herpetic as compared to HLA-B27 AU, mainly due to corneal scarring. The incidence rate of any ocular complication was higher in herpetic AU compared to HLA-B27-associated AU (0.140/EY versus 0.076/EY, p = <0.001), which was mainly due to glaucoma (0.033/EY versus 0.004/EY, p < 0.001) and cataract (0.059/EY versus 0.023/EY, p < 0.001).
  
  
  CONCLUSIONS
  The most prominent finding was a worse visual prognosis in herpetic AU, which is probably related to higher prevalence of corneal scarring and glaucoma. In addition, herpetic AU patients have more ocular complications overall.
authors.affiliation: a Department of Ophthalmology , University Medical Center Groningen, University of Groningen , Groningen , The Netherlands and.|b W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen , The Netherlands.
authors.forename: Lisette
authors.initials: L
authors.lastname: Hoeksema
authors.affiliation: a Department of Ophthalmology , University Medical Center Groningen, University of Groningen , Groningen , The Netherlands and.|b W. J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen , The Netherlands.
authors.forename: Leonoor I
authors.initials: LI
authors.lastname: Los
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000503:physiopathology; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012189:Retrospective Studies; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D014606:Uveitis, Anterior / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D014786:Vision Disorders / Q000209:etiology* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology*
chemical_list: D004279:DNA, Viral; D015796:HLA-B27 Antigen
keywords: Anterior uveitis; HLA-B27; herpes; ocular complications; visual prognosis