title: Polypropylene and polypropylene/polyglecaprone (Ultrapro®) meshes in the repair of incisional hernia in rats.
abstract: OBJECTIVE
  To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia.
  
  
  METHODS
  Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro(r) mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined scale of 0-3 degrees, evaluating infiltration of macrophages, giant cells, neutrophils and lymphocytes.
  
  
  RESULTS
  No significant difference was seen among groups in adherences, fibrosis, giant cells, macrophages, neutrophils or lymphocytes (p>0.05). Mesh shrinkage was observed in all groups, but also no difference was observed between polypropylene and Ultrapro mesh (7.0±9.9 vs. 7.4±10.1, respectively, p=0.967). Post-operatory complications included fistula, abscess, dehiscence, serohematic collection and reherniation, but with no difference among groups (p=0.363).
  
  
  CONCLUSIONS
  There is no difference between polypropylene (high-density) and Ultrapro(r) (low-density) meshes at 21 days after surgery in extraperitoneal use in rats, comparing inflammatory response, mesh shortening, adhesions or complications.
authors.affiliation: Department of Surgery, Medical School, Sao Paulo University, Brazil.
authors.forename: Edivaldo Massazo
authors.initials: EM
authors.lastname: Utiyama
authors.affiliation: Medical School, USP, Brazil.
authors.forename: Maria Beatriz Sartor de Faria
authors.initials: MB
authors.lastname: Rosa
authors.affiliation: Medical School, USP, Brazil.
authors.forename: Marina de Paula
authors.initials: Mde P
authors.lastname: Andres
authors.affiliation: Department of Surgery, Medical School, USP, Brazil.
authors.forename: Jocielle Santos de
authors.initials: JS
authors.lastname: Miranda
authors.affiliation: Department of Surgery, Medical School, USP, Brazil.
authors.forename: Sérgio Henrique Bastos
authors.initials: SH
authors.lastname: Damous
authors.affiliation: Department of Surgery, Medical School, USP, Brazil.
authors.forename: Cláudio Augusto Vianna
authors.initials: CA
authors.lastname: Birolini
authors.affiliation: Department of Obstetrics and Gynecology, Medical School, USP, Brazil.
authors.forename: Luciana Lamarão
authors.initials: LL
authors.lastname: Damous
authors.affiliation: Department of Surgery, Medical School, USP, Brazil.
authors.forename: Edna Frasson de Souza
authors.initials: EF
authors.lastname: Montero
mesh_terms: D000818:Animals; D004146:Dioxanes / Q000627:therapeutic use*; D006555:Hernia, Ventral / Q000473:pathology / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008422:Materials Testing; D011091:Polyesters / Q000627:therapeutic use*; D011126:Polypropylenes / Q000627:therapeutic use*; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013526:Surgical Mesh; D013997:Time Factors; D000267:Tissue Adhesions; D016896:Treatment Outcome
chemical_list: D004146:Dioxanes; D011091:Polyesters; D011126:Polypropylenes; C095495:glycolide E-caprolactone copolymer