title: PP059. Characteristics of body inflammatory reaction during the implementation of differentiated therapy of preeclampsia in perioperative care.
abstract: OBJECTIVE
  To learn features of the electrolyte balanced starch solution of Tetraspan in comparison with standard starch solutions in therapy of preeclampsia. The advantages of Tetraspan (B Braun®) application were the composition, which is due to electrolyte composition near to blood plasma absence of negative influence on kidneys and on curtailing system of blood.
  
  
  METHODS
  220 puerperal women with preeclampsia after cesarean section were investigated. They were divided into two groups: In the basic group n=110, the composition of infusion therapy included Tetraspan, in comparison group n=110 one of the well known hydroxyethylstarch solution. The control group include puerperal women (n=100) without preeclampsia infusion therapy of this group did not include starch solutions. Efficiency of therapy was estimated on a clinical picture, body fluid's sectors examination in dynamics and cytokine profile (proinflammatory IL1â, IL 6 and anti-inflammatory IL 10) immunological examination. Inspections were spent on 1st and 5th days after Cesarean section.
  
  
  RESULTS
  The cytokines profile: the 1st day in the basic group: IL1 â-124±13.1, IL 6 - 56.2±19.1, IL 10 62±11. At 5th day: IL1 â 109±13.5, IL 6 - 41.6±17.3, IL 10 52±13. At comparison group -1st day: IL1 â-123±10.9, IL 6 - 51.3±28.2, IL1 â 10 63.4±14.1. At 5th day: IL1 â 112±24, IL 6 - 47±26.3, IL 10 61±18.4.
  
  
  METHODS
  At 1st day: IL1 â -82±15.2, IL 6 - 33.3±21.1, IL10 98.7±13.6. At 5th day: IL1 â - 114±12.6, IL 6 - 27.1±18.3, IL 10 - 64.9±12.6.
  
  
  CONCLUSIONS
  The cytokines dynamic profile examination from the first to fifth day in basic group (in comparison with the second group) shows timely minimization of proinflammatory cytokines level and increase of the anti-inflammatory cytokines, which has good prognostic indication in recovery period. Modeling influence of Tetraspan at the inflammatory answer provides early decrease of proinflammatory and increase of anti-inflammatory markers level. Thus, on the basis of clinical and laboratory inspection results proved the efficiency of Tetraspan and recommends to apply this electrolyte balanced starch solution in perioperative therapy of average and heavy preeclampsia.
authors.forename: Galiya
authors.initials: G
authors.lastname: Jonboboeva
authors.forename: Aleksey
authors.initials: A
authors.lastname: Pyregov