title: NMR assignments of the C-terminal domain of human galectin-8.
abstract: Galectins recognize β-galectosides to promote a variety of cellular functions. Despite their sequence variations, all galectins share the same carbohydrate recognition domains (CRD) and their modes of ligand recognition at a structural level are essentially identical. Human galectin 8 plays an important role in numerous cancer and immune responses. It consists of two CRDs that are connected via a flexible linker. The substrate affinities and specificities of the N- and C-terminal domains are quite different. In order to investigate the structural basis of their substrate specificities, we complete the NMR (1)H, (13)C, and (15)N chemical shift assignments of C-terminal domain of human galectin-8 (hG8C).
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.|Institue of Bioinformatics and Structural Biology, National Tsin Hua University, Hsinchu, 30013, Taiwan.|Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Nankang, Taipei, 11529, Taiwan.
authors.forename: Chun-Hao Gerard
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.|Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
authors.forename: Chih-Ta Henry
authors.initials: CT
authors.lastname: Chien
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.|Department of Chemistry, National Taiwan University, Taipei, 106, Taiwan.|Institute of Biochemical Science, National Taiwan University, Taipei, 106, Taiwan.
authors.forename: Chun-Hung
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan. sthsu@gate.sinica.edu.tw.|Institute of Biochemical Science, National Taiwan University, Taipei, 106, Taiwan. sthsu@gate.sinica.edu.tw.
authors.forename: Shang-Te Danny
authors.initials: ST
authors.lastname: Hsu
mesh_terms: D000595:Amino Acid Sequence; D037161:Galectins / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D037161:Galectins; C091991:LGALS8 protein, human
keywords: Carbohydrate recognition domain; Galectin 8; NMR spectroscopy