title: Multifunctional gold nanoparticles as signal transducers for fabrication of 1:2 molecular demultiplexer.
abstract: A label-free and enzyme-free demultiplexer system for the fabrication of 1:2 molecular demultiplexer with luminol functionalized gold nanoparticles (Lum-AuNPs) as signal transducers was developed for the first time. The Lum-AuNPs had both chemiluminescence (CL) activity and surface plasmon resonance property. It was found that organothiols (RSH) could easily induce the aggregation of AuNPs via strong Au-S covalent interactions in the absence of hydrogen peroxide (H2O2), generating a red shift in the absorption band of AuNPs. However, the presence of H2O2 would readily oxidize RSH to disulfide (RS-SR), and the aggregation of Lum-AuNPs did not occur due to lack of the sulfhydryl group. Meanwhile, H2O2 could react with Lum-AuNPs, producing a strong CL emission owing to the enhancement effect of RSH on AuNPs-luminol-H2O2 CL system. Thus, RSH, H2O2, absorbance ratio, and CL intensity served as the signal input, address input, and two different signal outputs of the 1:2 molecular demultiplexer, respectively.
authors.affiliation: School of National Defence Science & Technology, Southwest University of Science and Technology, Mianyang, 621010, China, yhe2014@126.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.forename: Haili
authors.initials: H
authors.lastname: Yu
mesh_terms: D039301:Computers, Molecular; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D020349:Surface Plasmon Resonance / Q000295:instrumentation*
chemical_list: D006046:Gold