title: Molecular Basis of Drug Resistance in Mycobacterium tuberculosis.
abstract: In this chapter we review the molecular mechanisms of drug resistance to the major first- and second-line antibiotics used to treat tuberculosis.
authors.affiliation: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa.
authors.forename: Keira A
authors.initials: KA
authors.lastname: Cohen
authors.affiliation: Johns Hopkins School of Medicine, The Center for TB Research, 1550 Orleans St., CRBII, Room 103, Baltimore, MD 21287.
authors.forename: William R
authors.initials: WR
authors.lastname: Bishai
authors.affiliation: KwaZulu-Natal Research Institute for TB and HIV (K-RITH), Nelson R. Mandela School of Medicine, 719 Umbilo Road, Durban, 4001, South Africa.
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Pym
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D020125:Mutation, Missense; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000995:Antitubercular Agents