title: Comparative study on the effects of aqueous extracts of viscum album (mistletoe) from three host plants on hematological parameters in albino rats.
abstract: BACKGROUND
  The extract of the leaves of Viscum album (mistletoe) has been used for centuries in traditional medicine in many parts of the world. However, like many medicinal plants, the belief that things of natural origin are safe may not be entirely true. The blood is a good indicator of health and pathological mirror of the entire body.
  
  
  OBJECTIVE
  Therefore, in this study, the acute effects of extracts of mistletoe, harvested from three hosts, on haematology indices of wistar albino rats was investigated.
  
  
  METHODS
  Graded doses (400, 800, 1600 and 3200mg/kg body weight) of aqueous extracts of mistletoe from three different host plants, coffee (Coffee arabica), kola (Kola nitida), cocoa (Theobromae cacao), were administered orally to wistar albino rats for 14 days. Full haematological parameters were evaluated on whole blood collected from rats twenty four hours after the administration of the last dose.
  
  
  RESULTS
  Mistletoe from kola caused a concentration dependent and statistically significant (p<0.05) reduction in platelets count in rats. Administration of mistletoe extract from cocoa and coffee led to reduction in hemoglobin concentration. Reductions in packed cell volume (PCV) and red blood cell (RBC) and increase in white blood cells (WBC) were also observed in rats administered all the extracts.
  
  
  CONCLUSIONS
  Increase in the WBC count observed in rats administered mistletoe suggests that mistletoe extract contains agents that could stimulate the production of leucocytes and could serve as immune booster. However, there is need to be cautious in administration at high doses to prevent the risk of anaemia.
authors.affiliation: Department of Biochemistry, Lead City University, Ibadan, Oyo state, Nigeria.
authors.forename: Olusola
authors.initials: O
authors.lastname: Ladokun
authors.affiliation: Department of Biochemistry, Lead City University, Ibadan, Oyo state, Nigeria.
authors.forename: Matthew
authors.initials: M
authors.lastname: Ojezele
authors.affiliation: Department of Biochemistry, Lead City University, Ibadan, Oyo state, Nigeria.
authors.forename: Oluwatosin
authors.initials: O
authors.lastname: Arojojoye
mesh_terms: D000818:Animals; D001799:Blood Sedimentation / Q000187:drug effects*; D002099:Cacao; D040503:Coffea; D030221:Cola; D004912:Erythrocytes / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D028182:Viscum album / Q000737:chemistry*
chemical_list: D006454:Hemoglobins; D010936:Plant Extracts
keywords: Viscum album; coffee arabica; haematology; kola nitida; theobromae cacao