title: A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases.
abstract: Microbial pathogens are known to express an array of specific signaling molecules referred as Pathogen Associated Molecular Patterns (PAMPs), which are recognized by Pattern Recognition Receptors (PRRs), present on the surface of the host cells. Interactions between PAMPs and PRRs on the surface of the host cells lead to signaling events which could culminate into either successful infection or clearance of the pathogens. Here, we summarize how these events may generate novel host based as well as pathogen based molecular targets for designing effective therapeutic strategies against infections.
authors.affiliation: a School of Life Sciences ; Central University of Himachal Pradesh ; Shahpur, District-Kangra , Himachal Pradesh , India.
authors.forename: Aarti
authors.initials: A
authors.lastname: Rana
authors.affiliation: b School of Earth and Environmental Sciences ; Central University of Himachal Pradesh ; Shahpur, District-Kangra , Himachal Pradesh , India.
authors.forename: Mushtaq
authors.initials: M
authors.lastname: Ahmed
authors.affiliation: c Infection and Immunity Lab ; Department of Biotechnology ; Jamia Millia Islamia (A Central University) ; New Delhi , India.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rub
authors.affiliation: a School of Life Sciences ; Central University of Himachal Pradesh ; Shahpur, District-Kangra , Himachal Pradesh , India.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akhter
mesh_terms: D056704:Adaptive Immunity; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000627:therapeutic use; D003141:Communicable Diseases / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D007114:Immunization / Q000379:methods; D007155:Immunologic Factors / Q000302:isolation & purification / Q000627:therapeutic use; D000069452:Pathogen-Associated Molecular Pattern Molecules / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000890:Anti-Infective Agents; D007155:Immunologic Factors; D000069452:Pathogen-Associated Molecular Pattern Molecules; D051192:Receptors, Pattern Recognition
keywords: PAMPs; PRRs; actin remodelling; host-pathogen interaction; signaling cascades