title: Genetics of Type 2 Diabetes and Clinical Utility.
abstract: A large proportion of heritability of type 2 diabetes (T2D) has been attributed to inherent genetics. Recent genetic studies, especially genome-wide association studies (GWAS), have identified a multitude of variants associated with T2D. It is thus reasonable to question if these findings may be utilized in a clinical setting. Here we briefly review the identification of risk loci for T2D and discuss recent efforts and propose future work to utilize these loci in clinical setting-for the identification of individuals who are at particularly high risks of developing T2D and for the stratification of specific health-care approaches for those who would benefit most from such interventions.
authors.affiliation: Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. dorajoor@gis.a-star.edu.sg.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Dorajoo
authors.affiliation: Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. liuj3@gis.a-star.edu.sg.|Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore. liuj3@gis.a-star.edu.sg.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Genome Institute of Singapore, Agency for Science, Technology and Research, 138672, Singapore. Bernhard.boehm@ntu.edu.sg.|Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. Bernhard.boehm@ntu.edu.sg.|Imperial College London, London, SW7 2AZ, UK. Bernhard.boehm@ntu.edu.sg.|Department of Endocrinology, Tan Tock Seng Hospital, Singapore 308433, Singapore. Bernhard.boehm@ntu.edu.sg.
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Boehm
keywords: clinical utility; genetics; type 2 diabetes