title: miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression.
abstract: Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (SCA1) neurodegenerative disease and some types of cancer; however, the role of CIC in prostate cancer remains unknown. Here we show that CIC suppresses prostate cancer progression. CIC expression was markedly decreased in human prostatic carcinoma. CIC overexpression suppressed prostate cancer cell proliferation, invasion, and migration, whereas CIC RNAi exerted opposite effects. We found that knock-down of CIC derepresses expression of ETV5 and CRABP1 in LNCaP and PC-3 cells, respectively, thereby promoting cell proliferation and invasion. We also discovered that miR-93, miR-106b, and miR-375, which are known to be frequently overexpressed in prostate cancer patients, cooperatively down-regulate CIC levels to promote cancer progression. Altogether, we suggest miR-93/miR-106b/miR-375-CIC-CRABP1 as a novel key regulatory axis in prostate cancer progression.
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Nahyun
authors.initials: N
authors.lastname: Choi
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Jongmin
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Yoe
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Guk Yeol
authors.initials: GY
authors.lastname: Park
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Eunjeong
authors.initials: E
authors.lastname: Kim
authors.affiliation: Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Hyeongrin
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Yong Mee
authors.initials: YM
authors.lastname: Cho
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.|Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Roh
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.|Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Kyungbuk, Republic of Korea.
authors.forename: Yoontae
authors.initials: Y
authors.lastname: Lee
mesh_terms: D017209:Apoptosis; D002277:Carcinoma / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004268:DNA-Binding Proteins / Q000378:metabolism; D018450:Disease Progression; D015536:Down-Regulation; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D009361:Neoplasm Invasiveness; D011471:Prostatic Neoplasms / Q000378:metabolism*; D034622:RNA Interference; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C498610:CIC protein, human; D004268:DNA-Binding Proteins; C086680:ETV5 protein, human; C542541:MIRN106 microRNA, human; C540933:MIRN375 microRNA, human; C543350:MIRN93 microRNA, human; D035683:MicroRNAs; D018168:Receptors, Retinoic Acid; D012097:Repressor Proteins; D014157:Transcription Factors; C082927:retinoic acid binding protein I, cellular
keywords: CRABP1; ETV5; capicua; microRNA; prostate cancer