title: Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography.
abstract: To detect early structural changes of macular ganglion cell complex (GCC), peripapillary nerve fiber layer (pNFL), and optic nerve head (ONH) topography in subjects with pseudoexfoliation (PEX) using 3-D spectral domain optical coherence tomography (SD-OCT, Topcon 3D-2000).
  
  
  
  Thirty-five participants with PEX and 29 healthy control subjects were included in the study. All study participants underwent SD-OCT imaging. Macular NFL, ganglion cell layer and inner plexiform layer (GCL + IPL), pNFL, and ONH parameters were measured in each participant. The results were compared within the two groups.
  
  
  
  In eyes with PEX, the superior and total mNFL thickness; superior, and total GCL + IPL thickness; superior, inferior, and total GCC thickness; and inferior, temporal, nasal, and total pNFL thickness were significantly thinner than the control subjects. In the topographic evaluation of ONH, there was no significant difference in optic disc area (ODA), cup area, rim area, cup to disc ratio (CDR), cup volume, rim volume, linear CDR and vertical CDR between the two groups.
  
  
  
  In PEX syndrome, similar decreases of the GCC and NFL occurred, and a high correlation existed between the two. Therefore, GCC can potentially be used to detect the early stages of PEX glaucoma.
authors.affiliation: a Istanbul Research and Training Hospital , Istanbul , Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Eltutar
authors.affiliation: a Istanbul Research and Training Hospital , Istanbul , Turkey.
authors.forename: Fahrettin
authors.initials: F
authors.lastname: Acar
authors.affiliation: a Istanbul Research and Training Hospital , Istanbul , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kayaarası Öztürker
authors.affiliation: a Istanbul Research and Training Hospital , Istanbul , Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Ünsal
authors.affiliation: a Istanbul Research and Training Hospital , Istanbul , Turkey.
authors.forename: Sezin
authors.initials: S
authors.lastname: Özdoğan Erkul
mesh_terms: D000368:Aged; D058452:Axial Length, Eye / Q000473:pathology*; D003315:Cornea / Q000473:pathology*; D017889:Exfoliation Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology*; D011446:Prospective Studies; D012372:ROC Curve; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields
keywords: Optic nerve head; pseudoexfoliation syndrome; retinal ganglion cell complex; retinal nerve fiber layer; spectral-domain optical coherence tomography