title: (18)F-FDG PET/MRI for therapy response assessment in sarcoma: comparison of PET and MR imaging results.
abstract: BACKGROUND
  (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has proven to be of substantial benefit in imaging of sarcoma patients. We therefore investigated the feasibility and benefit of combined PET/magnetic resonance imaging (MRI).
  
  
  METHODS
  Twelve patients with sarcoma who underwent FDG PET/MRI for staging and response assessment after chemotherapy were included.
  
  
  RESULTS
  Based on contrast-enhanced MRI and application of Choi criteria, therapy response was classified as stable disease in 6/12 patients (50%) and as partial remission in 6/12 patients (50%).
  
  
  CONCLUSIONS
  In sarcoma patients, response assessment using Choi criteria based on contrast-enhanced MRI in comparison to FDG PET imaging only demonstrates slight correlation.
authors.affiliation: Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden. Electronic address: markus.schuler@uniklinikum-dresden.de.
authors.forename: Markus Kajo
authors.initials: MK
authors.lastname: Schuler
authors.affiliation: Department of Radiology, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden.
authors.forename: Ivan
authors.initials: I
authors.lastname: Platzek
authors.affiliation: Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden.
authors.forename: Bettina
authors.initials: B
authors.lastname: Beuthien-Baumann
authors.affiliation: General Practice of Radiology, Berlin.
authors.forename: Michael
authors.initials: M
authors.lastname: Fenchel
authors.affiliation: Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstraße 74, 01307, Dresden.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.affiliation: PET Center Rossendorf, Bautzner Landstraße 400, 01328, Dresden.
authors.forename: Jörg
authors.initials: J
authors.lastname: van den Hoff
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005240:Feasibility Studies; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012509:Sarcoma / Q000175:diagnosis* / Q000188:drug therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Cancer imaging; Choi criteria; FDG PET/MRI; Sarcoma