title: Imiquimod-induced subacute cutaneous lupus erythematosus-like changes.
abstract: Imiquimod is a topical immunomodulator used to treat genital warts and cutaneous malignancies that exerts its effects via induction of proinflammatory cytokines through activation of toll-like receptor (TLR) 7. Although subacute cutaneous lupus erythematosus (SCLE) has been reported in association with multiple systemic medications, SCLE in patients treated with topical agents has not been widely reported. We report the case of a 50-year-old woman with local induction of lesions that clinically and histologically resembled SCLE following treatment with topical imiquimod.
authors.forename: Sheilagh M
authors.initials: SM
authors.lastname: Maguiness
authors.affiliation: Palo Alto Medical Foundation, 701 E El Camino Real, Mountain View, CA 94306, USA. tfarsani@gmail.com.
authors.forename: Terry T
authors.initials: TT
authors.lastname: Farsani
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Zedek
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Berger
mesh_terms: D000634:Aminoquinolines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D007155:Immunologic Factors / Q000009:adverse effects*; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000634:Aminoquinolines; D007155:Immunologic Factors; D000077271:Imiquimod