title: (-)Epigallocatechin-3-gallate decreases the stress-induced impairment of learning and memory in rats.
abstract: Stress induces reactive oxygen species (ROS) and causes alterations in brain cytoarchitecture and cognition. Green tea has potent antioxidative properties especially the tea catechin (-) epigallocatechin-3-gallate (EGCG). These powerful antioxidative properties are able to protect against various oxidative damages. In this study we investigated the impact of stress on rats' locomotor activity, learning and memory. Many tea catechins, including EGCG, were examined for their possible therapeutic effects in treating stress-induced impairment. Our results indicated that locomotor activity was decreased, and the learning and memory were impaired in stressed rats (SRs). EGCG treatment was able to prevent the decreased locomotor activity as well as improve the learning and memory in SRs. EGCG treatment was also able to reduce the increased oxidative status in SRs' hippocampi. The above results suggest a therapeutic effect of EGCG in treating stress-induced impairment of learning and memory, most likely by means of its powerful antioxidative properties.
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, PR China; Department of Psychiatry, Yuan-Shan br. of Taipei Veteran General Hospital, Yilan County 26604, Taiwan, PR China.
authors.forename: Hung-Sheng
authors.initials: HS
authors.lastname: Soung
authors.affiliation: Department of Anesthesia, En-Chu-Kon Hospital, Sanxia District, New Taipei City 23702, Taiwan, PR China.
authors.forename: Mao-Hsien
authors.initials: MH
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan, PR China.
authors.forename: Hsiang-Chien
authors.initials: HC
authors.lastname: Tseng
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, PR China.
authors.forename: Hsu-Wei
authors.initials: HW
authors.lastname: Fang
authors.affiliation: Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan, PR China.
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Chang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007859:Learning Disabilities / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology; D009043:Motor Activity / Q000187:drug effects; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D012149:Restraint, Physical; D065853:Spatial Learning / Q000187:drug effects; D013315:Stress, Psychological / Q000150:complications / Q000523:psychology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D002392:Catechin; C045651:epigallocatechin gallate
keywords: (-) Epigallocatechin-3-gallate (EGCG); Learning and memory; Morris water maze and stress; Open field test