title: Platelet-Rich Plasma: A Study of the Variables that May Influence Its Effect on Bone Regeneration.
abstract: BACKGROUND
  Currently, the use of platelet-rich plasma in bone regeneration is a real option, although more than one opinion has alerted us to the absence of clinical benefits.
  
  
  OBJECTIVE
  Analysis of the factors able to modify the characteristics of the platelet preparation obtained by Curasan, Plasma Rich in Growth Factors (PRGF), Platelet Concentrate Collection System (PCCS) and SmartPrep systems, relating them to the type of clinical application and the final bone regeneration achieved.
  
  
  METHODS
  A search was conducted in PubMed using the keywords "platelet-rich plasma," "PRP," "platelet rich growth factors," and "oral bone regeneration." Four widely accepted protocols for the obtention of PRP (above) were analyzed. Any clinical studies with controls, using the four preparation protocols and with a 4 to 6 weeks follow-up period were compared. The protocols were also grouped according to the type of PRP application: PRP-alone, with bone, or with bone substitutes.
  
  
  RESULTS
  Bone regeneration was not achieved in any of the cases using PRP obtained by Curasan and PCCS systems, whereas PRP obtained by SmartPrep achieved it only in one in three published cases and PRGF in one in six.
  
  
  CONCLUSIONS
  Based on the poor results observed in current literature, the use of PRP in oral surgery cannot be recommended.
authors.affiliation: Faculty of Health Sciences, Universidad CEU Cardenal Herrera, Valencia, Spain. marjovani@uch.ceu.es.
authors.forename: Mª Del Mar
authors.initials: MD
authors.lastname: Jovani-Sancho
authors.affiliation: Department of Biomedical Sciences, Faculty of Health Sciences, Universidad CEU Cardenal Herrera, Valencia, Spain.
authors.forename: Chirag C
authors.initials: CC
authors.lastname: Sheth
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Mariano
authors.initials: M
authors.lastname: Marqués-Mateo
authors.affiliation: Hospital Clínico Universitario, Universidad de Valencia, Valencia, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Puche-Torres
mesh_terms: D001861:Bone Regeneration / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D019647:Oral Surgical Procedures / Q000379:methods; D053657:Platelet-Rich Plasma
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: PRP; oral bone regeneration; platelet-rich growth factors; platelet-rich plasma