title: Visible Light Induces Melanogenesis in Human Skin through a Photoadaptive Response.
abstract: Visible light (400-700 nm) lies outside of the spectral range of what photobiologists define as deleterious radiation and as a result few studies have studied the effects of visible light range of wavelengths on skin. This oversight is important considering that during outdoors activities skin is exposed to the full solar spectrum, including visible light, and to multiple exposures at different times and doses. Although the contribution of the UV component of sunlight to skin damage has been established, few studies have examined the effects of non-UV solar radiation on skin physiology in terms of inflammation, and limited information is available regarding the role of visible light on pigmentation. The purpose of this study was to determine the effect of visible light on the pro-pigmentation pathways and melanin formation in skin. Exposure to visible light in ex-vivo and clinical studies demonstrated an induction of pigmentation in skin by visible light. Results showed that a single exposure to visible light induced very little pigmentation whereas multiple exposures with visible light resulted in darker and sustained pigmentation. These findings have potential implications on the management of photo-aggravated pigmentary disorders, the proper use of sunscreens, and the treatment of depigmented lesions.
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: Manpreet
authors.initials: M
authors.lastname: Randhawa
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: InSeok
authors.initials: I
authors.lastname: Seo
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: Frank
authors.initials: F
authors.lastname: Liebel
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Southall
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: Nikiforos
authors.initials: N
authors.lastname: Kollias
authors.affiliation: Johnson and Johnson Skin Research Center, CPPW, a unit of Johnson & Johnson Consumer Companies Inc., Skillman, New Jersey, United States of America.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruvolo
mesh_terms: D065638:Absorption, Radiation; D000222:Adaptation, Physiological / Q000528:radiation effects*; D000328:Adult; D005260:Female; D005786:Gene Expression Regulation / Q000528:radiation effects; D006801:Humans; D008027:Light; D008543:Melanins / Q000096:biosynthesis*; D008875:Middle Aged; D014442:Monophenol Monooxygenase / Q000378:metabolism; D012867:Skin / Q000528:radiation effects*; D012880:Skin Pigmentation / Q000528:radiation effects; D013057:Spectrum Analysis
chemical_list: D008543:Melanins; D014442:Monophenol Monooxygenase