title: The Role of Remote Ischemic Preconditioning in Ischemia-Reperfusion Injury in Rabbits with Transplanted Lung.
abstract: BACKGROUND
  To observe the influence of remote ischemic preconditioning (R-IPC) and remote ischemic perconditioning (R-IPER) on the lower limbs of rabbits with lung allograft ischemia-reperfusion injury (IRI).
  
  
  METHODS
  Sixty rabbits were randomly divided into one of four groups: control (C), classic ischemic preconditioning (C-IPC), R-IPC, and R-IPER. The allogeneic lung transplantation model was established in rabbits, and the protective effects of R-IPC and R-IPER on transplanted lungs were determined and compared to classic ischemic preconditioning (C-IPC) IRI. Changes in blood oxygen were measured in each group before and after transplantation. After transplantation, levels of serum malondialdehyde (MDA), superoxide dismutase (SOD), and tumor necrosis factor-α (TNF-α), lung wet/dry weight ratio, as well as quantitative and organizational differences in the lungs were analyzed.
  
  
  RESULTS
  After reperfusion, blood oxygen values in the R-IPC group and C-IPC groups were higher than in the C and R-IPER groups at 60 minutes and 120 minutes after transplantation (p < 0.05). Serum SOD content in the R-IPC and C-IPC groups was higher than in the C and R-IPER groups (p < 0.05) after reperfusion. Serum MDA, TNF-α level, and lung wet/dry weight ratio and quantitative measurements of histological damage were lower in the R-IPC and the C-IPC groups than those in the C and R-IPER groups (p < 0.05). No statistically significant differences were observed between the L-IP and the C-IP groups or between the R-IPER and the C groups.
  
  
  CONCLUSIONS
  Classic preconditioning and remote preconditioning of rabbit lung allograft IRI had similar protective effects. The lower limb ischemia with the remote processing method used in this experiment did not produce a protective effect for lung allograft IRI.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Mei
authors.initials: M
authors.lastname: Ma
authors.forename: Liang
authors.initials: L
authors.lastname: Zong
authors.forename: Xiaheding
authors.initials: X
authors.lastname: Yiliyaer
authors.forename: Haiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis; D019194:Ischemic Preconditioning; D016040:Lung Transplantation; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D014184:Transplantation, Homologous