title: Does EBV alter the pathogenesis of malaria?
abstract: Plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of Epstein-Barr virus, thereby increasing the risk of endemic Burkitt lymphoma in children. However, the impact of Epstein-Barr virus infections on the development of immunity to P. falciparum has not been studied in depth. In this review, we examine novel findings from animal co-infection models and human immuno-epidemiologic studies to speculate on the impact of acute gammaherpesvirus co-infection on malarial disease severity. Children are often concurrently or sequentially infected with multiple pathogens, and this has implications for understanding the development of protective immunity as well as in the evaluation of vaccine efficacy.
authors.affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Matar
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: N T
authors.initials: NT
authors.lastname: Jacobs
authors.affiliation: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.|Emory Vaccine Center, Emory University, Atlanta, GA, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Speck
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Lamb
authors.affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Moormann
mesh_terms: D000208:Acute Disease; D017954:Africa South of the Sahara / Q000453:epidemiology; D000818:Animals; D002051:Burkitt Lymphoma / Q000469:parasitology / Q000821:virology; D002648:Child; D060085:Coinfection / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines
keywords: animal models; co-infection; epidemiologic studies; immunity