title: Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions.
abstract: Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental rat model of dementia. Rats with scopolamine-induced amnesia were assessed in the object location task with different DBS parameters. Moreover, anxiety-related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied c-Fos immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and CA1 sub-region was able to restore memory loss when a specific set of stimulation parameters was used. No anxiety-related side effects were found following DBS. The beneficial behavioral performance of CA1 DBS rats was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute CA1 DBS restores memory loss possibly through improved attentional and cognitive processes in the limbic cortex.
authors.affiliation: Department of Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), The Netherlands. Electronic address: sarah.hescham@maastrichtuniversity.nl.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hescham
authors.affiliation: Department of Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), The Netherlands.
authors.forename: Ali
authors.initials: A
authors.lastname: Jahanshahi
authors.affiliation: Department of Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), The Netherlands.
authors.forename: Céline
authors.initials: C
authors.lastname: Meriaux
authors.affiliation: Department of Biological Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Physiology, the University of Hong Kong, Hong Kong.
authors.forename: Lee Wei
authors.initials: LW
authors.lastname: Lim
authors.affiliation: Departments of Neuropsychology and Psychopharmacology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), The Netherlands.
authors.forename: Arjan
authors.initials: A
authors.lastname: Blokland
authors.affiliation: Department of Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; Departments of Neurosurgery, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands; European Graduate School of Neuroscience (Euron), The Netherlands. Electronic address: y.temel@maastrichtuniversity.nl.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Temel
mesh_terms: D000818:Animals; D020643:Anterior Thalamic Nuclei / Q000503:physiopathology / Q000601:surgery; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology* / Q000601:surgery; D056547:CA1 Region, Hippocampal / Q000503:physiopathology / Q000601:surgery; D046690:Deep Brain Stimulation; D003704:Dementia / Q000503:physiopathology* / Q000517:prevention & control; D004195:Disease Models, Animal; D018728:Entorhinal Cortex / Q000503:physiopathology / Q000601:surgery; D008326:Mammillary Bodies / Q000503:physiopathology / Q000601:surgery; D008568:Memory / Q000502:physiology*; D009043:Motor Activity; D009434:Neural Pathways / Q000503:physiopathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016760:Proto-Oncogene Proteins c-fos
keywords: Circuit of Papez; Deep brain stimulation; Enthorhinal cortex; Hippocampus; Memory