title: Directed Amination of Aryl Methyl Ethers Mediated by Ti(NMe2)4 at Room Temperature.
abstract: An efficient C-O amination of aryl methyl ethers has been achieved. This transformation proceeds via imine-directed Ti(IV)-mediated cross-coupling reactions between aryl methyl ethers and Ti(NR2)4 at room temperature, straightforwardly leading to a series of arylamines. This protocol features a wide substrate scope, exclusive regioselectivity, and mild reaction conditions.
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Chen
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Jinna
authors.initials: J
authors.lastname: Liu
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Pei
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Chen
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: ‡Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Qinghai 810008, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Li
authors.affiliation: †College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Jiangsu 215006, China.
authors.forename: Yahong
authors.initials: Y
authors.lastname: Li
mesh_terms: D000586:Amination; D056831:Coordination Complexes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008738:Methyl Ethers / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature; D014025:Titanium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D007097:Imines; D008738:Methyl Ethers; D014025:Titanium