title: Cellular backpackers deliver lymphoma drugs.
abstract: Researchers have attached capsules containing the drug SN-38, a relative of irinotecan, to T cells. When infused into mice with a cancer similar to Burkitt lymphoma, the T cells entered the spleen, lymph nodes, and bone marrow where B-cell tumors occurred, increasing the amount of drug reaching the tumors compared with other methods, and prolonging survival.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D016503:Drug Delivery Systems; D006801:Humans; D000077146:Irinotecan; D008223:Lymphoma / Q000188:drug therapy* / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D000077146:Irinotecan; D002166:Camptothecin