title: Molecular genetics of coronary artery disease.
abstract: Coronary artery disease (CAD) including myocardial infarction (MI) is a common disease and among the leading cause of death in the world. The onset of CAD depends on complex interactions of environmental and genetic factors. To clarify the genetic architecture of MI, we started a genome-wide association study (GWAS) using nearly 100 000 gene-based single-nucleotide polymorphisms (SNPs) from 2000, and identified LTA associated with the increased risk of MI in Japanese population. To our knowledge, this is the first study identified a genetic factor for common disease by GWAS in the worldwide. Through examining the LTA cascade by combination of molecular biological and genetic analyses, we have identified additional MI susceptible genes, LGALS2, PSMA6 and BRAP, so far. Nowadays a lot of large-scale GWAS have identified numerous genetic risk factors for common diseases. In CAD, 51 loci with GWAS significance (P<5 × 10(-8)) have collectively identified by recent large-scale GWAS mainly in Caucasian descent. In this review, we discuss recent advances in molecular genetics for CAD.
authors.affiliation: Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ozaki
authors.affiliation: Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.|Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.|Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Toshihiro
authors.identifier: http://orcid.org/0000-0001-6201-9784
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D037501:Galectin 2 / Q000235:genetics; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics; D009203:Myocardial Infarction / Q000235:genetics; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: D037501:Galectin 2; C511926:LGALS2 protein, human; D008233:Lymphotoxin-alpha; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases; C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex