title: Subjects with isolated GH deficiency due to a null GHRHR mutation eat proportionally more, but healthier than controls.
abstract: The GH/IGF-I axis has important interactions with the alimentary system and with the balance between energy intake (EI) and energy requirement (ER). Reduced EI has been described in adult-onset acquired GH deficiency (GHD). Individuals from the Brazilian Itabaianinha cohort, with isolated GHD (IGHD) due to a homozygous mutation (c.57+1G→A) in the GHRH receptor gene, are an ideal model to study the consequences of lifetime GHD. The purpose of this study is to evaluate EI and ER in this untreated IGHD cohort. Cross-sectional study of 24 adult IGHD patients and 23 controls from the same region, matched for age and gender. Estimated EI (EEI) was evaluated by dietary recall, and estimated ER (EER) by the equation of the Dietary Reference Intakes. Fat mass was assessed by DXA. Both EEI and EER were lower in IGHD than controls. However, when corrected by body weight, EEI was higher in IGHD (p = 0.005). IGHD individuals consume in percentage more proteins (p < 0.0001), less carbohydrates (p = 0.013), and equal amount of lipids in comparison to controls. The higher EEI per body weight suggests a possible increase of orexigenic mechanisms in untreated IGHD individuals, ensuring greater caloric intake, which would have adaptive advantages for small-sized individuals in environments with limited access to food. IGHD individuals seem to have a healthier dietary pattern than CO.
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Alécia A
authors.initials: AA
authors.lastname: Oliveira-Santos
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street Suite #333, Baltimore, MD, 21287, USA. salvator@jhmi.edu.
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvatori
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Elenilde
authors.initials: E
authors.lastname: Gomes-Santos
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: João A M
authors.initials: JA
authors.lastname: Santana
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Ângela C G B
authors.initials: ÂC
authors.lastname: Leal
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Rita A A
authors.initials: RA
authors.lastname: Barbosa
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Carla R P
authors.initials: CR
authors.lastname: Oliveira
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Anita H O
authors.initials: AH
authors.lastname: Souza
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Eugênia H O
authors.initials: EH
authors.lastname: Valença
authors.affiliation: Division of Endocrinology, Federal University of Sergipe, Aracaju, SE, 49060-100, Brazil.
authors.forename: Manuel H
authors.initials: MH
authors.lastname: Aguiar-Oliveira
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D003430:Cross-Sectional Studies; D004393:Dwarfism, Pituitary / Q000235:genetics* / Q000503:physiopathology; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000235:genetics; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D018013:Receptors, Neuropeptide / Q000235:genetics*; D018017:Receptors, Pituitary Hormone-Regulating Hormone / Q000235:genetics*
chemical_list: D018013:Receptors, Neuropeptide; D018017:Receptors, Pituitary Hormone-Regulating Hormone; C048250:somatotropin releasing hormone receptor
keywords: Dietary intake; Energy expenditure; GH deficiency