title: TSH-secreting pituitary adenoma: benefits of pre-operative octreotide.
abstract: TSH-secreting pituitary adenomas are rare and the optimal investigation and management is uncertain. We describe a case of a 43 year-old woman with a TSH-secreting pituitary adenoma, highlighting diagnostic testing and our use, pre-operatively of somatostatin analogue therapy, which induced biochemical euthyroidism and a reduction in tumour size.
  
  
  CONCLUSIONS
  The differential diagnosis of the syndrome of inappropriate TSH secretion is non-thyroidal illness, medications, assay interference due to heterophilic antibodies, thyroid hormone resistance and TSH-secreting pituitary adenoma.TRH stimulation test and triiodothyronine suppression test assist in differentiating thyroid hormone resistance and TSH-secreting pituitary adenoma.Somatostatin analogue therapy can induce biochemical euthyroidism and reduce tumour size.
authors.affiliation: Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital , Grosvenor Road, Belfast, BT12 6BA , UK.
authors.forename: I R
authors.initials: IR
authors.lastname: Wallace
authors.affiliation: Department of Neuropathology, Royal Victoria Hospital , Grosvenor Road, Belfast, BT12 6BA , UK.
authors.forename: E
authors.initials: E
authors.lastname: Healy
authors.affiliation: Department of Neurosurgery, Royal Victoria Hospital , Grosvenor Road, Belfast, BT12 6BA , UK.
authors.forename: R S
authors.initials: RS
authors.lastname: Cooke
authors.affiliation: Department of Radiology, Royal Victoria Hospital , Grosvenor Road, Belfast, BT12 6BA , UK.
authors.forename: P K
authors.initials: PK
authors.lastname: Ellis
authors.affiliation: Department of Endocrinology and Diabetes, Ulster Hospital , Dundonald, BT16 1RH , UK.
authors.forename: R
authors.initials: R
authors.lastname: Harper
authors.affiliation: Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital , Grosvenor Road, Belfast, BT12 6BA , UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Hunter