title: Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.
abstract: Silica and iron oxide nanoparticles with sizes ranging from 6 to 40 nm were functionalized with trehalose. The trehalose-conjugated nanoparticles showed strong interactions with Mycobacterium smegmatis (M. smegmatis) and minimal interactions with macrophage (RAW 264.7) or A549 cells. In addition, trehalose-conjugated silica nanoparticles selectively interacted with M. smegmatis on M. smegmatis-treated A549 cells, demonstrating high potential of trehalose in developing targeted therapy for treating mycobacterial infection.
authors.affiliation: Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA. mingdi_yan@uml.edu.
authors.forename: Kalana W
authors.initials: KW
authors.lastname: Jayawardana
authors.forename: H Surangi N
authors.initials: HS
authors.lastname: Jayawardena
authors.forename: Samurdhi A
authors.initials: SA
authors.lastname: Wijesundera
authors.forename: Thareendra
authors.initials: T
authors.lastname: De Zoysa
authors.forename: Madanodaya
authors.initials: M
authors.lastname: Sundhoro
authors.forename: Mingdi
authors.initials: M
authors.lastname: Yan
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology*; D020102:Mycobacterium smegmatis / Q000302:isolation & purification / Q000378:metabolism*; D053758:Nanoparticles / Q000378:metabolism* / Q000648:ultrastructure; D014199:Trehalose / Q000378:metabolism*
chemical_list: D014199:Trehalose