title: Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea.
abstract: Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-to-severe OSA. This case-control study aims to investigate the relationship between genetic variations in the ZFP36 gene and moderate-to-severe OSA. Three common single nucleotide polymorphisms of the ZFP36 gene (rs251864, rs3746083, and rs17879933) were evaluated in a group of patients with moderate-to-severe OSA (N = 408) and in a control group (N = 394) by using TaqMan polymerase chain reaction analysis. The moderate-to-severe OSA group and the control group exhibited significant differences in the distributions of rs251864 and rs17879933 genotypes and alleles (P < 0.05). TNF-α levels were significantly different not only among the three rs251864 genotypes but also between the II genotype and the DD + ID genotypes of rs17879933. However, no significant differences in sleep apnea parameters in the three ZFP36 gene polymorphisms were observed. Logistic regression analyses demonstrated that TNF-α and the three ZFP36 gene polymorphisms were not independently associated with OSA. ZFP36 might be involved in TNF-α regulation. However, ZFP36 gene variants were not independent risk factors for moderate-to-severe OSA.
authors.affiliation: Department of Cadre Ward, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: N-F
authors.initials: NF
authors.lastname: Li
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: S
authors.initials: S
authors.lastname: Abulikemu
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: D-L
authors.initials: DL
authors.lastname: Zhang
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Wang
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Kong
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: G-L
authors.initials: GL
authors.lastname: Nuer
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: Z-T
authors.initials: ZT
authors.lastname: Yan
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Li
authors.affiliation: Center for Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Center for Diagnosis, Treatment and Research of Hypertension, Xinjiang, Urumqi, China.
authors.forename: J-H
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Cadre Ward, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China xiangyangzhangcn@126.com.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007249:Inflammation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017286:Polysomnography; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D012720:Severity of Illness Index; D015398:Signal Transduction; D020181:Sleep Apnea, Obstructive / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D051816:Tristetraprolin / Q000235:genetics* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D051816:Tristetraprolin; D014409:Tumor Necrosis Factor-alpha; C497552:ZFP36 protein, human