title: Adjuvant Chemoradiation Therapy in Gastric Cancer: Critically Reviewing the Past and Visualizing the Next Step Forward.
abstract: Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallmark INT-0116 trial, minimal progress has been made both in terms of effectiveness and toxicity. Moreover, new regimens added to combined therapy failed to prove favourable results. Herein, we attempt a thorough literature review comparing pros and cons of all relative studies and potential bias, targeting well-designed future approaches.
authors.affiliation: Department of Medical Oncology, University of Antwerp, 2650 Antwerp, Belgium.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Papadimitriou
authors.affiliation: Department of Medical Oncology, Royal Marsden Hospital NHS Foundation Trust, London SW3 6JJ, UK.
authors.forename: Georgios
authors.initials: G
authors.lastname: Antoniou
authors.affiliation: Department of Medical Oncology, University of Antwerp, 2650 Antwerp, Belgium.
authors.forename: Christian
authors.identifier: 0000-0002-5109-0267
authors.initials: C
authors.lastname: Rolfo
authors.affiliation: Department of Surgical and Oncology Sciences, University of Palermo, 90127 Palermo, Italy.
authors.forename: Antonio
authors.identifier: 0000-0002-4370-2008
authors.initials: A
authors.lastname: Russo
authors.affiliation: Department of Surgical and Oncology Sciences, University of Palermo, 90127 Palermo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bronte
authors.affiliation: Department of Radiation Oncology, B.O.C. Oncology Centre, 2006 Nicosia, Cyprus.
authors.forename: Vassilios
authors.initials: V
authors.lastname: Vassiliou
authors.affiliation: Department of Medical Oncology, B.O.C. Oncology Centre, 2006 Nicosia, Cyprus.
authors.forename: Demetris
authors.initials: D
authors.lastname: Papamichael
authors.affiliation: Department of Medical Oncology, University of Antwerp, 2650 Antwerp, Belgium.
authors.forename: Marc
authors.initials: M
authors.lastname: Peeters
authors.affiliation: Department of Medical Oncology, B.O.C. Oncology Centre, 2006 Nicosia, Cyprus.
authors.forename: Panteleimon
authors.initials: P
authors.lastname: Kountourakis