title: Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering.
abstract: Mechanical stimulus is of upmost importance in tissues developmental and regeneration processes as well as in maintaining body homeostasis. Classical physiological reactions encompass an increase of blood vessel diameter upon exposure to high blood pressure, or the expansion of cortical bone after continuous high-impact exercise. At a cellular level, it is well established that extracellular stiffness, topography, and remote magnetic actuation are instructive mechanical signals for stem cell differentiation. Based on this, biomaterials and their properties can be designed to act as true stem cell regulators, eventually leading to important advances in conventional tissue engineering techniques. This review identifies the latest advances and tremendous potential of magnetic actuation within the scope of regenerative medicine and tissue engineering.
authors.affiliation: 3B's Research Group, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Portugal.
authors.forename: Lívia J
authors.initials: LJ
authors.lastname: Santos
authors.affiliation: 3B's Research Group, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Portugal.
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
authors.affiliation: 3B's Research Group, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's, PT Government Associate Laboratory, Portugal. Electronic address: megomes@dep.uminho.pt.
authors.forename: Manuela E
authors.initials: ME
authors.lastname: Gomes
mesh_terms: D000818:Animals; D006801:Humans; D008280:Magnetics; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D051379:Mice; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*
keywords: activation of mechanotransduction signalling pathways; magnetic biomaterials; magnetic-based cell manipulation; mechanosensing machinery; regenerative medicine; stem cells