title: Tuberculosis associates with both airflow obstruction and low lung function: BOLD results.
abstract: In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spirometric abnormalities in adults.The study was performed in adults, aged 40 years and above, who took part in the multicentre, cross-sectional, general population-based Burden of Obstructive Lung Disease study, and had provided acceptable post-bronchodilator spirometry measurements and information on a history of tuberculosis. The associations between a history of tuberculosis and airflow obstruction and spirometric restriction were assessed within each participating centre, and estimates combined using meta-analysis. These estimates were stratified by high- and low/middle-income countries, according to gross national income.A self-reported history of tuberculosis was associated with airflow obstruction (adjusted odds ratio 2.51, 95% CI 1.83-3.42) and spirometric restriction (adjusted odds ratio 2.13, 95% CI 1.42-3.19).A history of tuberculosis was associated with both airflow obstruction and spirometric restriction, and should be considered as a potentially important cause of obstructive disease and low lung function, particularly where tuberculosis is common.
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK a.amaral@imperial.ac.uk.
authors.forename: André F S
authors.initials: AF
authors.lastname: Amaral
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Sonia
authors.initials: S
authors.lastname: Coton
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK.
authors.forename: Bernet
authors.initials: B
authors.lastname: Kato
authors.affiliation: University of British Columbia Heart Lung Innovation Center, Vancouver, BC, Canada.
authors.forename: Wan C
authors.initials: WC
authors.lastname: Tan
authors.affiliation: Department of Pulmonary Medicine, Paracelsus Medical University, Salzburg, Austria.
authors.forename: Michael
authors.initials: M
authors.lastname: Studnicka
authors.affiliation: Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Janson
authors.affiliation: Faculty of Medicine, University of Iceland and Landspitali University Hospital, Reykjavik, Iceland.
authors.forename: Thorarinn
authors.initials: T
authors.lastname: Gislason
authors.affiliation: Division of Pulmonary Critical Care and Sleep Medicine, University of Kentucky, Lexington, KY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Mannino
authors.affiliation: Department of Medicine, University of Cape Town, Cape Town, South Africa.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Bateman
authors.affiliation: Oregon Health & Sciences University, Portland, OR, USA.
authors.forename: Sonia
authors.initials: S
authors.lastname: Buist
authors.affiliation: Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK For a list of the BOLD collaborators see the Acknowledgements.
authors.forename: Peter G J
authors.initials: PG
authors.lastname: Burney
mesh_terms: D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008171:Lung Diseases / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology; D012107:Research Design; D012129:Respiratory Function Tests; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology; D013147:Spirometry; D011795:Surveys and Questionnaires; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000503:physiopathology; D014797:Vital Capacity
chemical_list: D001993:Bronchodilator Agents