title: [SODIUM SUCCINATE AS METHOD OF INTENSIVE CARE OPTIMIZATION OF NEWBORNS' MULTIORGAN FAILURE SYNDROM].
abstract: With the aim of ascertainment of pathogenesis of newborns' multiorgan failure syndrom it was made a research of lactat, pyruvate, urea containing and succinatedehydrogenase activity of newborns venous blood with sequences to perinatal infection and perinatal asphyxia. Was set the reliable increase of concentration of lactat, pyruvate and their ratio, that demonstrates the presence of cellular energy deficit. There was direct correlation communication between concentrations of pyruvate and urea. In the application of sodium succinate to reduce the content of lactic and pyruvic acids, their ratio, increase the activity of succinatedehydrogenase, which is evidence of improved mitochondrial energy production, as well as reduces the frequency of gastrointestinal insufficiency implementation.
authors.forename: D A
authors.initials: DA
authors.lastname: Shkurupiĭ
authors.forename: D A
authors.initials: DA
authors.lastname: Kholod
mesh_terms: D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal / Q000379:methods*; D019344:Lactic Acid / Q000097:blood; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009102:Multiple Organ Failure / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D019289:Pyruvic Acid / Q000097:blood; D013385:Succinate Dehydrogenase / Q000097:blood; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: C549374:Reamberin; D013386:Succinates; D019344:Lactic Acid; D008536:Meglumine; D019289:Pyruvic Acid; D013385:Succinate Dehydrogenase