title: Distant skin metastases as primary presentation of gastric cancer.
abstract: Distant gastric metastasis to the skin is uncommonly a presenting symptom, although nonspecific paraneoplastic syndromes with dermatologic manifestation including diffuse seborrheic keratoses (Leser-Trelat sign), tripe palms, and acanthosis nigricans have been described in the literature. We report here the case of a 49-year-old woman with gastric adenocarcinoma who presented with cutaneous metastasis as an initial symptom. In our case, metastatic skin lesions responded significantly to EOX chemotherapy (epirubicin+oxaliplatin+capecitabine) despite progression of systemic disease. In similar presentations, a high index of clinical suspicion and skin biopsy are important.
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ahmad
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Namali
authors.initials: N
authors.lastname: Pierson
authors.affiliation: Department of Internal Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Mohammed Muqueet
authors.initials: MM
authors.lastname: Adnan
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Minh
authors.initials: M
authors.lastname: Phan
authors.affiliation: Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Jenkins
authors.affiliation: Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Shubham
authors.initials: S
authors.lastname: Pant
authors.affiliation: Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Cherry
authors.affiliation: Hematology-Oncology Section, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. mohamad-khawandanah@ouhsc.edu.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Khawandanah
keywords: Skin metastasis; cutaneous metastasis; gastric cancer