title: Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9.
abstract: Chronic obstructive pulmonary disease (COPD) and asthma are both associated with airflow restriction and progressive remodeling, which affect the respiratory tract. Among various biological factors involved in the pathomechanisms of both diseases, proteolytic enzymes--matrix metalloproteinases (MMPs)--play an important role, especially MMP-9. In this review, the authors discuss the current topics of research concerning the possible role of MMP-9 in both mentioned diseases. They include the analysis of protein levels, nucleotide polymorphisms of MMP-9 gene and their possible correlation with asthma and COPD. Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.
authors.affiliation: Department of Paediatrics, Pneumonology and Allergology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Grzela
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Chalubinskiego 5, 02-004, Warsaw, Poland.|Potgraduate School of Molecular Medicine, Warsaw, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Litwiniuk
authors.affiliation: Department of Paediatrics, Pneumonology and Allergology, Medical University of Warsaw, Warsaw, Poland.
authors.forename: Wioletta
authors.initials: W
authors.lastname: Zagorska
authors.affiliation: Department of Histology and Embryology, Medical University of Warsaw, Chalubinskiego 5, 02-004, Warsaw, Poland. tomekgrzela@gmail.com.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grzela
mesh_terms: D056151:Airway Remodeling; D000818:Animals; D001249:Asthma / Q000276:immunology*; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology*
chemical_list: D020780:Matrix Metalloproteinase 9
keywords: Asthma; COPD; Chronic obstructive pulmonary disease; MMP-9; Remodeling