title: Mouse models of colorectal cancer as preclinical models.
abstract: In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative 'omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.
authors.affiliation: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: Rebecca E
authors.initials: RE
authors.lastname: McIntyre
authors.affiliation: Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Cambridge, UK.
authors.forename: Simon J A
authors.initials: SJ
authors.lastname: Buczacki
authors.affiliation: Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh, UK.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Arends
authors.affiliation: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000235:genetics*; D052138:Genes, Neoplasm; D006801:Humans; D058990:Molecular Targeted Therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000235:genetics*; D013045:Species Specificity; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents
keywords: colorectal cancer; disease biomarker; mouse model; ome and omics; target identification; target validation