title: Injectable biopolymer based hydrogels for drug delivery applications.
abstract: Biopolymer based pH-sensitive hydrogels were prepared using chitosan (CS) with polyethylene glycol (PEG) of different molecular weights in the presence of silane crosslinker. The incorporated components remain undissolved in different swelling media as they are connected by siloxane linkage which was confirmed by Fourier transform infrared spectroscopy. The swelling in water was enhanced by the addition of higher molecular weight PEG. The swelling behaviour of the hydrogels against pH showed high swelling in acidic and basic pH, whereas, low swelling was examined at pH 6 and 7. This characteristic pH responsive behaviour at neutral pH made them suitable for injectable controlled drug delivery. The controlled release analysis of Cefixime (CFX) (model drug) loaded CS/PEG hydrogel exhibited that the entire drug was released in 30 min in simulated gastric fluid (SGF) while in simulated intestinal fluid (SIF), 85% of drug was released in controlled manner within 80 min. This inferred that the developed hydrogels can be an attractive biomaterial for injectable drug delivery with physiological pH and other biomedical applications.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Sadia
authors.initials: S
authors.lastname: Atta
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan; Department of Polymer Engineering and Technology, University of the Punjab, Quaid-e-Azam campus, Lahore, Pakistan.
authors.forename: Shaista
authors.initials: S
authors.lastname: Khaliq
authors.affiliation: Department of Polymer Engineering and Technology, University of the Punjab, Quaid-e-Azam campus, Lahore, Pakistan. Electronic address: dratifislam@gmail.com.
authors.forename: Atif
authors.initials: A
authors.lastname: Islam
authors.affiliation: Department of Polymer Engineering and Technology, University of the Punjab, Quaid-e-Azam campus, Lahore, Pakistan; Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.
authors.forename: Irtaza
authors.initials: I
authors.lastname: Javeria
authors.affiliation: Department of Polymer Engineering and Technology, University of the Punjab, Quaid-e-Azam campus, Lahore, Pakistan.
authors.forename: Tahir
authors.initials: T
authors.lastname: Jamil
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Muhammad Makshoof
authors.initials: MM
authors.lastname: Athar
authors.affiliation: Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore, Pakistan.
authors.forename: Muhammad Imtiaz
authors.initials: MI
authors.lastname: Shafiq
authors.affiliation: Department of Chemistry, University of Engineering and Technology, Lahore, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Ghaffar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D020682:Cefixime / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry; D012821:Silanes / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D012821:Silanes; D011092:Polyethylene Glycols; D048271:Chitosan; D020682:Cefixime
keywords: Biopolymer; Drug delivery; Hydrogels; Injectable