title: Pd(II)-Catalyzed Direct Sulfonylation of Unactivated C(sp(3))-H Bonds with Sodium Sulfinates.
abstract: A Pd(II)-catalyzed sulfonylation of unactivated C(sp(3))-H bonds with sodium arylsulfinates using an 8-aminoquinoline auxiliary is described. This reaction demonstrates excellent functional group tolerance with respect to both the caboxamide starting material and the sodium arylsulfinate coupling partner, affording a broad range of aryl alkyl sulfones. Moreover, the late-stage modification of complex molecules was achieved via this sulfonylation protocol.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Wei-Hao
authors.initials: WH
authors.lastname: Rao
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhan
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Peng-Xiang
authors.initials: PX
authors.lastname: Ling
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Zhuo-Zhuo
authors.initials: ZZ
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry*; D013441:Sulfinic Acids / Q000737:chemistry*
chemical_list: D000634:Aminoquinolines; D013441:Sulfinic Acids; D010165:Palladium; D012964:Sodium; C080436:8-aminoquinoline