title: PP002. Study of polymorphisms of the adiponectin gene in women with gestational hypertension and preeclampsia.
abstract: BACKGROUND
  Adiponectin is involved in energy homeostasis by regulating glucose and lipid metabolism. Additionally, it presents anti-inflammatory and anti-atherosclerotic functions. Polymorphisms in adiponectin gene (ADIPOQ) can modulate the concentrations of adiponectin. The influence of these polymorphisms on the development of gestational hypertension (GH) and preeclampsia (PE) is unknown.
  
  
  OBJECTIVE
  The aim of this work was to examine the influence of polymorphisms in the gene ADIPOQ on the development of gestational hypertension and preeclampsia.
  
  
  METHODS
  
  
  
  METHODS
  We studied 401 pregnant women: 161 healthy pregnant (HP), 113 pregnant with gestational hypertension (GH) and 127 pregnant with preeclampsia (PE). Polymorphisms ADIPOQ -11391G>A (rs17300539), -11377C>G (rs266729), 45T>G (rs2241766) and 276G>T (rs1501299) were genotyped by allelic discrimination by PCR in real time. Haplotypes were inferred using the PHASE 2.1 program.
  
  
  RESULTS
  There were no statistically significant differences in allele and genotype frequencies of the polymorphisms studied. In the analysis of haplotypes, we observed small differences in haplotype frequencies between groups, however, none of these differences was statistically significant (P>0.05).
  
  
  CONCLUSIONS
  We found no association between the genotypic and allelic variants of the ADIPOQ gene polymorphisms with the development of gestational hypertension and preeclampsia.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: J S R
authors.initials: JS
authors.lastname: Machado
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: R C
authors.initials: RC
authors.lastname: Cavalli
authors.affiliation: IEP-SCBH, Santa Casa, Belo Horizonte, Brazil.
authors.forename: V C
authors.initials: VC
authors.lastname: Sandrim
authors.affiliation: Pharmacology, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: A C T
authors.initials: AC
authors.lastname: Palei
authors.affiliation: Pharmacology, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: L M
authors.initials: LM
authors.lastname: Amaral
authors.affiliation: Pediatrics, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: A C
authors.initials: AC
authors.lastname: Bueno
authors.affiliation: Pediatrics, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: S R R
authors.initials: SR
authors.lastname: Antonini
authors.affiliation: Pharmacology, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: J E
authors.initials: JE
authors.lastname: Tanus Santos
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Duarte