title: Arginine addiction in AML.
abstract: In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.
authors.affiliation: UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER.
authors.forename: William
authors.identifier: http://orcid.org/0000-0001-9311-2164
authors.initials: W
authors.lastname: Plunkett
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D006867:Hydrolases / Q000494:pharmacology*; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; D006867:Hydrolases