title: Polymorphisms in adiponectin receptor genes are associated with lipodystrophy-related phenotypes in HIV-infected patients receiving antiretroviral therapy.
abstract: OBJECTIVE
  Adiponectin is a circulating peptide secreted by mature adipocytes that may act as a regulator of glucose and lipid metabolism. This study aimed to investigate the association between genetic variability in the adiponectin receptor genes ADIPOR1 (adiponectin receptor 1) and ADIPOR2 and lipodystrophy and its related anthropometric and metabolic phenotypes in HIV-infected patients on highly active antiretroviral therapy (HAART).
  
  
  METHODS
  We studied six single nucleotide polymorphisms (SNPs) in the adiponectin receptor genes ADIPOR1 (rs1342387 and rs10920533) and ADIPOR2 (rs11061925, rs10773983, rs929434 and rs767870) and their association with adiponectin plasma levels, lipodystrophy subtypes and other parameters linked to glucose and lipid metabolism involved in the lipodystrophic syndrome. The genotypes of 407 HIV-infected patients receiving HAART were investigated using real-time polymerase chain reaction. Mean biochemical and anthropometrical parameters were compared between the different genotypes using analysis of variance.
  
  
  RESULTS
  Two ADIPOR2 SNPs (rs11061925 and rs929434) were associated with fasting plasma triglyceride concentrations in the entire sample. Stronger significant associations were found between these SNPs and biochemical parameters (levels of triglycerides, total cholesterol, adiponectin and glucose) in men. We did not find any significant associations with ADIPOR1 gene variants.
  
  
  CONCLUSIONS
  SNPs in the ADIPOR2 gene appear to be involved in the metabolic alterations in HIV-infected men receiving HAART.
authors.affiliation: Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
authors.forename: J K
authors.initials: JK
authors.lastname: Castilhos
authors.affiliation: Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Sprinz
authors.affiliation: Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: R K
authors.initials: RK
authors.lastname: Lazzaretti
authors.affiliation: Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Kuhmmer
authors.affiliation: Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
authors.forename: V S
authors.identifier: http://orcid.org/0000-0002-2697-4909
authors.initials: VS
authors.lastname: Mattevi
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000704:Analysis of Variance; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D054419:Receptors, Adiponectin / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D054419:Receptors, Adiponectin; D014280:Triglycerides
keywords: HIV; adiponectin receptors; dyslipidaemia; highly active antiretroviral therapy; lipodystrophy