title: Novel Inflammatory Indices in Aortic Disease.
abstract: Inflammation plays a critical role in the atherosclerotic process in various vascular beds, starting from endothelial dysfunction and counting all stages of plaque development. The significant contribution of inflammation in the initiation and progression of atherosclerosis has been documented over many years but its contribution to the development of other cardiovascular disease remains unclear. Inflammatory process constitutes a basic part of pathogenic cascade of aortic diseases including those of aortic valve stenosis and aortic aneurysms. Thus, both of these entities are related with high rates of morbidity and mortality. Therefore, the need to detect and investigate indices representative of inflammation that will be easily measured and may reflect the process of these diseases, is mandatory. However, such biomarkers for aortic diseases that could have a significant prognostic value on survival via the early identification of high risk patients, in general, remain few. Therefore, the illumination of role of such biomarkers, will facilitate the understanding of the mechanisms in molecular and/or cellular level that are responsible for the creation of aortic disease. Such an approach may provide a pathophysiological basis for early diagnosis.
authors.affiliation: 1st Department of Cardiology, Hippokration Hospital, Medical School, National & Kapodistrian, University of Athens, Greece. vavouran@otenet.gr.
authors.forename: Manolis
authors.initials: M
authors.lastname: Vavuranakis
authors.forename: Maria
authors.initials: M
authors.lastname: Kariori
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vrachatis
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Siasos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kalogeras
authors.forename: Evelina
authors.initials: E
authors.lastname: Bei
authors.forename: Carmen
authors.initials: C
authors.lastname: Moldovan
authors.forename: Maria
authors.initials: M
authors.lastname: Lavda
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Aznaouridis
authors.forename: Evangelos
authors.initials: E
authors.lastname: Oikonomou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
mesh_terms: D000818:Animals; D001014:Aortic Aneurysm / Q000378:metabolism* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology
chemical_list: D015415:Biomarkers