title: Association between β1 adrenergic receptor gene Arg389Gly polymorphism and risk of heart failure: a meta-analysis.
abstract: Numerous studies have evaluated the association between Arg389Gly polymorphism in the β1 adrenergic receptor gene and heart failure risk. However, the specific association is still controversial. We performed a meta-analysis of all case-control studies that evaluated the association between Arg389Gly polymorphism and heart failure in humans. Studies were identified in the PubMed, Embase, and China National Knowledge Infrastructure databases. Two reviewers independently assessed the studies. Six case-control studies with a total of 1736 participants were included in the meta-analysis, including 882 cases with heart failure and 854 controls, and our results showed no association between the Arg389Gly polymorphism and heart failure [ArgArg vs GlyGly: odds ratio (OR) = 0.84, 95% confidence interval (CI) 0.59-1.20; ArgArg vs ArgGly: OR = 0.95, 95%CI 0.78-1.16; dominant model: OR = 1.08, 95%CI 0.89-1.31; recessive model: OR = 0.96, 95%CI 0.69-1.35]. No publication bias was found in the present study (all P values > 0.05). In conclusion, the β1 adrenergic receptor gene Arg389Gly polymorphism might not be associated with heart failure risk. Further large and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Department of Cardiology, The Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
authors.forename: S T
authors.initials: ST
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Shandong Jiaotong Hospital, Shandong, China.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Jinan Institute of Cardiovascular Disease, The Fourth People's Hospital of Jinan, Jinan, Shandong, China.
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Jinan Institute of Cardiovascular Disease, The Fourth People's Hospital of Jinan, Jinan, Shandong, China.
authors.forename: R Y
authors.initials: RY
authors.lastname: Jia
authors.affiliation: Department of Cardiology, Jinan Institute of Cardiovascular Disease, The Fourth People's Hospital of Jinan, Jinan, Shandong, China.
authors.forename: C J
authors.initials: CJ
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, The Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China cui_lianqun@126.com.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Cui
mesh_terms: D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006333:Heart Failure / Q000235:genetics* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C547787:ADRB1 protein, human; D018342:Receptors, Adrenergic, beta-1