title: Transdermal delivery of antidiabetic drugs: formulation and delivery strategies.
abstract: Most oral antidiabetic drugs exhibit low oral bioavailability and need to be taken more than once daily owing to short half-lives, resulting in poor patient compliance. There is a necessity for improved drug delivery devices for antidiabetic agents because of the scale of their use and short-comings associated with their conventional dosage forms. This review presents an outline of transdermal research specifically in the area of antidiabetic drugs, showing that several transdermal approaches have been made to enhance delivery of these drugs via the skin barrier, significantly improving bioavailability as well as patient compliance.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia. Electronic address: abdulahad20@yahoo.com.
authors.forename: Abdul
authors.initials: A
authors.lastname: Ahad
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Abdulmohsen A
authors.initials: AA
authors.lastname: Al-Saleh
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Buraydah Private Colleges, PO Box 31717, Buraydah, Al-Qassim 51418, Saudi Arabia.
authors.forename: Naseem
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Al-Mohizea
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Fahad I
authors.initials: FI
authors.lastname: Al-Jenoobi
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003920:Diabetes Mellitus / Q000188:drug therapy; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D055118:Medication Adherence; D012869:Skin Absorption
chemical_list: D007004:Hypoglycemic Agents