title: Cardiopulmonary Exercise Testing in Children and Adolescents With Dystrophinopathies: A Pilot Study.
abstract: OBJECTIVE
  To determine exercise response during cardiopulmonary exercise testing in children and adolescents with dystrophinopathies.
  
  
  METHODS
  Exercise response on the cardiopulmonary exercise test (CPET) was compared with a standard care test protocol.
  
  
  RESULTS
  Nine boys (aged 10.8 ± 4.7 years) with Becker muscular dystrophy (n = 6) and Duchenne muscular dystrophy (n = 3) were included. The feasibility of the CPET was similar to a standard care test protocol, and no serious adverse events occurred. In 67% of the subjects with normal or only mildly impaired functional capacity, the CPET could be used to detect moderate to severe cardiopulmonary exercise limitations.
  
  
  CONCLUSIONS
  The CPET seems to be a promising outcome measure for cardiopulmonary exercise limitations in youth with mild functional limitations. Further research with larger samples is warranted to confirm current findings and investigate the additional value of the CPET to longitudinal follow-up of cardiomyopathy and the development of safe exercise programs for youth with dystrophinopathies.
authors.affiliation: Child Development and Exercise Center (Mr Bartels, Drs Takken and de Groot), Wilhelmina Children's Hospital, University Medical Center, Utrecht, the Netherlands; Department of Pediatric Cardiology (Dr Blank), Wilhelmina Children's Hospital, University Medical Center Utrecht, the Netherlands; Research Group Lifestyle and Health (Mr van Moorsel and Dr de Groot), University of Applied Sciences, Utrecht, the Netherlands; Department of Neurology (Dr van der Pol), University Medical Center Utrecht, the Netherlands.
authors.forename: Bart
authors.initials: B
authors.lastname: Bartels
authors.forename: Tim
authors.initials: T
authors.lastname: Takken
authors.forename: A Christian
authors.initials: AC
authors.lastname: Blank
authors.forename: Huib
authors.initials: H
authors.lastname: van Moorsel
authors.forename: W Ludo
authors.initials: WL
authors.lastname: van der Pol
authors.forename: Janke F
authors.initials: JF
authors.lastname: de Groot
mesh_terms: D000293:Adolescent; D002648:Child; D005080:Exercise Test / Q000379:methods*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000503:physiopathology*; D010101:Oxygen Consumption / Q000502:physiology; D010809:Physical Fitness / Q000502:physiology*; D010865:Pilot Projects; D012129:Respiratory Function Tests