title: [Effect of intravenous infusion of KCl on the electrocardiogram and serum potassium in dogs with normal renal function].
abstract: Variations in serum potassium (K+) and electrocardiographic changes at different infusion speeds of intravenous K+ were studied in dogs. Solutions of 20, 40, 60 and 80 mEq of K+ were infused in one hour to dogs with normal renal function and normal serum K+. Nine dogs were studied: three without prior hydration and six with previous hydration. Infusing 20 mEq/hour of K+ produced an increase in heart rate without changes in the electrocardiogram. With 40 mEq/hour there were changes in the "t" and "p" waves, and with 60 and 80 mEq/hour, alterations consistent with cardiac ischemia and ventricular tachycardia. Dogs without hydration had more obvious and fatal electrocardiographic changes. Doses of 20 mEq/hour of K + caused no morbidity or mortality in the animals studied. Higher doses showed various complications which depended on the hydration status of the animal, its urinary flow and potassium level.
authors.affiliation: Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Jessica
authors.initials: J
authors.lastname: Bravo-Zúñiga
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Julio
authors.initials: J
authors.lastname: Huapaya
authors.affiliation: Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Cesar
authors.initials: C
authors.lastname: Valencia
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Sandra
authors.initials: S
authors.lastname: Bezada
authors.affiliation: Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Cristian
authors.initials: C
authors.lastname: Leon
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Renato
authors.initials: R
authors.lastname: Ferrandiz-Espadin
authors.affiliation: Departamento de Medicina, Universidad Peruana Cayetano Heredia, Lima, Perú
authors.forename: Javier
authors.initials: J
authors.lastname: Cieza
mesh_terms: D000818:Animals; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects*; D007262:Infusions, Intravenous; D007668:Kidney / Q000502:physiology*; D011188:Potassium / Q000097:blood*; D011189:Potassium Chloride / Q000008:administration & dosage* / Q000494:pharmacology*; D012016:Reference Values
chemical_list: D011189:Potassium Chloride; D011188:Potassium