title: Arterial stiffness is increased in healthy subjects with a positive family history of hypertension.
abstract: A positive family history of hypertension is a risk factor for cardiovascular diseases. We investigated the value of pulse wave velocity (PWV) in healthy subjects with a positive family history of hypertension. 255 healthy subjects (M/F: 75/180) were divided into two groups according to without (group 1) or with (group 2) a positive family history of hypertension. Carotid-femoral pulse wave velocity (CF-PWV) was measured by Complior apparatus. Our results showed that CF-PWV was significantly higher in group 2 than in group 1 (7.90 ± 1.31 versus 7.32 ± 1.15 m/s, p < 0.001). High-density lipoprotein cholesterol (HDL-C) was significantly higher in group 1 than in group 2. Multiple linear regressions showed that age, family history, GLU, and MAP were independent influencing factors of CF-PWV in the entire study group. Our present study showed PWV is significantly higher in healthy subjects with a positive family history of hypertension. Family history might play an important role in this process.
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Liu
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wang
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhao
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Li
authors.affiliation: a Department of Vascular Medicine , Peking University Shougang Hospital , Beijing , PR China.
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
keywords: Arterial stiffness; arteriosclerosis; family history; hypertension; pulse wave velocity