title: Metallothionein Lower Under-Expression in Benign Tumors than That in Malignant Tumors: Systematic Review Article and Meta-Analysis.
abstract: Metallothionein (MT) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. A meta-analysis was conducted to evaluate comprehensively the MT expression difference in various benign tumors and malignant tumors, which compared the high with low MT expression levels in patients of the available studies. Finally, a total of 13 studies dealing with various tumors were involved for this meta-analysis. The results indicated that lower expression of MT in various benign tumors tissue than that in corresponding malignant tumors with the pooled OR of 0.52 (95 % CI 0.18-1.47, P < 0.001). In conclusion, MT expression difference is associated with tumor various stages in tumor patients and could be a useful clinical criteria of distinguishing benign tumors and malignant tumors for those patients.
authors.affiliation: 1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: 2. Dept. of Medicine, Shandong Wanjie Medical College , Zibo, China.
authors.forename: Ruijie
authors.initials: R
authors.lastname: Sun
authors.affiliation: 1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 3. Dept. of Laboratory Medicine, the First Hospital of Zibo City , Zibo, China.
authors.forename: Guinian
authors.initials: G
authors.lastname: Wang
authors.affiliation: 1. Key Laboratory of Biomedical Engineering & Technology of Shandong High School, Shandong Wanjie Medical College , Zibo, China.
authors.forename: Qinglu
authors.initials: Q
authors.lastname: Wang
keywords: Benign tumors; Malignant tumors; Meta-analysis; Metallothionein