title: Plasma glial cell line-derived neurotrophic factor in patients with major depressive disorder: a preliminary study.
abstract: BACKGROUND
  Some clinical studies have reported reduced peripheral glial cell line-derived neurotrophic factor (GDNF) level in elderly patients with major depressive disorder (MDD). We verified whether a reduction in plasma GDNF level was associated with MDD.
  
  
  METHODS
  Plasma GDNF level was measured in 23 healthy control subjects and 23 MDD patients before and after 6 weeks of treatment.
  
  
  RESULTS
  Plasma GDNF level in MDD patients at baseline did not differ from that in healthy controls. Plasma GDNF in MDD patients did not differ significantly from baseline to the end of treatment. GDNF level was significantly lower in recurrent-episode MDD patients than in first-episode patients before and after treatment.
  
  
  CONCLUSIONS
  Our findings revealed significantly lower plasma GDNF level in recurrent-episode MDD patients, although plasma GDNF levels in MDD patients and healthy controls did not differ significantly. The discrepancy between our study and previous studies might arise from differences in the recurrence of depression or the ages of the MDD patients.
authors.affiliation: 1Department of Psychiatry,Seoul Eunpyeong Hospital,Seoul,Republic of Korea.
authors.forename: Bun-Hee
authors.initials: BH
authors.lastname: Lee
authors.affiliation: 2Department of Psychiatry,Samsung Medical Center,Seoul,Republic of Korea.
authors.forename: Jin-Pyo
authors.initials: JP
authors.lastname: Hong
authors.affiliation: 3Department of Psychiatry,Korea University Ansan Hospital,Kyunggi,Republic of Korea.
authors.forename: Jung-A
authors.initials: JA
authors.lastname: Hwang
authors.affiliation: 4Department of Psychiatry,Gacheon University Gil Medical Center,Incheon,Republic of Korea.
authors.forename: Kyoung-Sae
authors.initials: KS
authors.lastname: Na
authors.affiliation: 5Translational Addiction Research Laboratory, Center for Addiction and Mental Health (CAMH),Toronto,Ontario,Canada.
authors.forename: Won-Joong
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: 5Translational Addiction Research Laboratory, Center for Addiction and Mental Health (CAMH),Toronto,Ontario,Canada.
authors.forename: Jose
authors.initials: J
authors.lastname: Trigo
authors.affiliation: 3Department of Psychiatry,Korea University Ansan Hospital,Kyunggi,Republic of Korea.
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000328:Adult; D003863:Depression / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D003865:Major Depressive Disorder / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor
keywords: affective disorder; glial cell line-derived neurotrophic factor; major depressive disorder; protein analysis