title: Dosing Cefepime for Renal Function Does Not Completely Prevent Neurotoxicity in a Patient With Kidney Transplant.
abstract: Dosing cefepime for renal function does not completely prevent neurotoxicity in a kidney transplant patient. Cefepime neurotoxicity has been reported primarily among patients with renal insufficiency who received standard doses of the antibiotic. We report a case of nonconvulsive status epilepticus from dose-adjusted cefepime in a kidney transplant patient. The timing of symptoms along with clinical and electroencephalographic improvement after discontinuation of cefepime was critical to the diagnosis. Whether we should adjust the dose of cefepime differently in a patient with transplanted kidney to prevent neurotoxicity is unknown.
authors.affiliation: From the Department of Medicine, and.
authors.forename: Percy Guanzon
authors.initials: PG
authors.lastname: Balderia
authors.affiliation: From the Department of Medicine, and.
authors.forename: Aditya
authors.initials: A
authors.lastname: Chandorkar
authors.affiliation: †Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: Yongwoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: From the Department of Medicine, and.
authors.forename: Soumya
authors.initials: S
authors.lastname: Patnaik
authors.affiliation: From the Department of Medicine, and.
authors.forename: Joshua
authors.initials: J
authors.lastname: Sloan
authors.affiliation: †Department of Neurosensory Sciences, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
authors.forename: George Charles
authors.initials: GC
authors.lastname: Newman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000077723:Cefepime / Q000008:administration & dosage / Q000009:adverse effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D011183:Postoperative Complications / Q000188:drug therapy; D011704:Pyelonephritis / Q000188:drug therapy; D013226:Status Epilepticus / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D000077723:Cefepime