title: [CLINICAL EFFICACY OF SUSTAINED HIGH-EFFICACY DAILY DIAFILTRATION USING A MEDIATOR-ADSORBING MEMBRANE AND DIRECT HEMOPERFUSION WITH A POLYMYXIN B-IMMOBILIZED FIBER COLUMN IN TREATING ACUTE EXACERBATION OF IDIOPATHIC INTERSTITIAL PNEUMONIAS].
abstract: OBJECTIVE
  The aim of this study is to investigate the clinical outcomes of patients with steroid-resistant acute exacerbation of idiopathic interstitial pneumonias treated with blood purification therapy comprising direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP) and sustained high-efficacy daily diafiltration using a mediator-adsorbing membrane (SHEDD-fA).
  
  
  METHODS
  The clinical outcomes and respiratory function were retrospectively compared between 6 patients who underwent blood purification therapy (blood purification group) and 15 patients (control group) who blood purification therapy.
  
  
  RESULTS
  The patients in the blood purification group showed a higher PaO2/FiO2 ratio than those in the control group. Twenty-eight days (83%; 5/6 vs. 20%; 3/15) and ninety days (67%; 4/6 vs. 6.7%; 1/15) survival rates were also higher in the blood purification group. The blood purification group also showed a better 90-day survival curve (Hazard ratio=0.260) compared to the control group.
  
  
  CONCLUSIONS
  In conclusion, combination blood purification therapy comprising PMX-DHP and SHEDD-fA may be used to treat acute exacerbation of idiopathic interstitial pneumonias.
authors.affiliation: Department of Respiratory Medicine, Matsunami General Hospital.
authors.forename: Chihito
authors.initials: C
authors.lastname: Komaki
authors.affiliation: Department of Respiratory Medicine, Matsunami General Hospital.
authors.forename: Takashi
authors.initials: T
authors.lastname: Niwa
authors.affiliation: Department of Respiratory Medicine, Matsunami General Hospital.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Inoue
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011112:Polymyxin B / Q000737:chemistry*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011112:Polymyxin B