title: Secrets from the microbiome: molecular biology meets microbiology meets histopathology...meets clinical biochemistry.
abstract: The microbiome is the collective term used to describe the bacteria, viruses, fungi and archaea that reside on and in the human body. The majority of these organisms are found within the large bowel. Mounting evidence suggests that changes in the microbiome may be associated with the development of colorectal cancer, a disease which affects 1.3 million people a year worldwide. Using colorectal cancer as an example, this article presents the inter-specialty collaborative approach to microbiome research and discusses the key role that clinical biochemistry is likely to play.
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, UK c.young@leeds.ac.uk.
authors.forename: Caroline
authors.initials: C
authors.lastname: Young
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, UK.
authors.forename: Philip
authors.initials: P
authors.lastname: Quirke
mesh_terms: D000368:Aged; D002624:Chemistry, Clinical; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D006801:Humans; D033183:Interdisciplinary Communication; D008829:Microbiology; D064307:Microbiota; D008875:Middle Aged; D008967:Molecular Biology
keywords: Tumour markers; analytes; cancer; clinical studies; gastro-intestinal disorders