title: Development of SHIVs with circulating, transmitted HIV-1 variants.
abstract: SHIV/macaque model is critical for pre-clinical HIV-1 research. The ability of this model to predict efficacious intervention(s) in humans depends on how faithfully the model recapitulates key features of HIV-1 transmission and pathogenesis. Here, we provide insights for rationally designing SHIVs with transmitted HIV-1 variants for vaccine and prevention research.
authors.affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.|Pathobiology Graduate Program, University of Washington, Seattle, WA, USA.
authors.forename: David F
authors.initials: DF
authors.lastname: Boyd
authors.affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
keywords: HIV-1 envelope; SHIV/macaque model; transmitted/founder HIV-1