title: Black tea extract improves anti-oxidant profile in experimental diabetic rats.
abstract: OBJECTIVE
  The purpose of this study was to investigate the in vivo anti-oxidant effect of black tea extract (BTE) supplemented to normal and alloxan-induced diabetic rats.
  
  
  METHODS
  Black tea extract (BTE) was fed to control and experimental diabetic rats by gavage technique at a dose of 1 ml/100 g body weight/day. Markers of oxidative stress in blood were determined.
  
  
  RESULTS
  Results show a significant (P < 0.01) decrease (73%) in plasma anti-oxidant potential, increase in activity of plasma membrane redox system (122%), protein oxidation and lipid peroxidation in diabetic rats, BTE supplemented diabetic rats had improved anti-oxidant profile and lower protein and lipid peroxidation levels. Diabetic rats displayed lower intracellular glutathione (GSH), BTE supplementation improved GSH levels.
  
  
  CONCLUSIONS
  Results of this study suggest that the 2.5% aqueous extract of black tea is effective to ameliorate diabetes associated oxidative stress parameters in experimental model of diabetes.
authors.affiliation: Department of Biochemistry, University of Allahabad , Allahabad U.P. , India.
authors.forename: Dileep
authors.initials: D
authors.lastname: Kumar
authors.forename: Syed Ibrahim
authors.initials: SI
authors.lastname: Rizvi
mesh_terms: D000284:Administration, Oral; D062107:Advanced Oxidation Protein Products / Q000097:blood; D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D015415:Biomarkers / Q000097:blood; D028241:Camellia sinensis / Q000737:chemistry*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D062107:Advanced Oxidation Protein Products; D000975:Antioxidants; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D000496:Alloxan; D005978:Glutathione
keywords: Anti-oxidants; black tea; diabetes; oxidative stress