title: Double trouble in human aneuploidy.
abstract: Crossing over, or reciprocal recombination, is essential for accurate segregation of homologous chromosomes at the first meiotic division, resulting in gametes containing the correct chromosome number. A new study in human oocytes analyzes the genome-wide recombination and segregation patterns in all the products of female meiosis, providing experimental support for existing theories about the origin of human aneuploidies and highlighting a novel reverse segregation mechanism of chromosome segregation during meiosis.
authors.affiliation: Department of Biomedical Sciences and the Center for Reproductive Genomics, Cornell University, Ithaca, New York, USA.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Brieño-Enríquez
authors.affiliation: Department of Biomedical Sciences and the Center for Reproductive Genomics, Cornell University, Ithaca, New York, USA.
authors.forename: Paula E
authors.initials: PE
authors.lastname: Cohen
mesh_terms: D020090:Chromosome Segregation; D005260:Female; D006801:Humans; D011995:Recombination, Genetic