title: Collision-Induced Dissociation Mass Spectrometry: A Powerful Tool for Natural Product Structure Elucidation.
abstract: Mass spectrometry is a powerful tool in natural product structure elucidation, but our ability to directly correlate fragmentation spectra to these structures lags far behind similar efforts in peptide sequencing and proteomics. Often, manual data interpretation is required and our knowledge of the expected fragmentation patterns for many scaffolds is limited, further complicating analysis. Here, we summarize advances in natural product structure elucidation based upon the application of collision induced dissociation fragmentation mechanisms.
authors.affiliation: Department of Chemistry, Indiana University , 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Johnson
authors.affiliation: Department of Chemistry, Indiana University , 800 East Kirkwood Avenue, Bloomington, Indiana 47405, United States.|Department of Molecular and Cellular Biochemistry, Indiana University , 212 South Hawthorne Drive, Bloomington, Indiana 47405, United States.
authors.forename: Erin E
authors.initials: EE
authors.lastname: Carlson
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: D000617:Aminoglycosides; D001688:Biological Products; C017186:demycarosylturimycin H