title: Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells.
abstract: A number of seaweed species are used as traditional foods and medicine in different parts of the world, including Asian countries. However, very few data on the anti-melanogenic effect of seaweed have been published. Undaria pinnatifida (Dolmiyeok), a brown alga, is a traditional food in Jeju Island, the southern regions of the Korea peninsula. In this study, ethylacetate extracts of U. pinnatifida (UPE) were examined for their anti-melanogenic potentials. Our results supports the finding that UPE down-regulated melanin content in a dose-dependent pattern. To clarify the target of UPE action in melanogenesis, we performed Western blotting for tyrosinase and microphthalmia-associated transcription factor (MITF), which are key melanogenic enzymes. UPE inhibited tyrosinase and MITF expressions in a dose-dependent manner. These results indicate that treatment with UPE significantly inhibits the melanogenesis in B16 cells, and may be effective in the whitening agent for the skin.
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Min-Jin
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Dong Sam
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Hun-Seok
authors.initials: HS
authors.lastname: Yoon
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea.
authors.forename: Wook Jae
authors.initials: WJ
authors.lastname: Lee
authors.affiliation: Cosmetic Science Center, Faculty of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea.
authors.forename: Nam Ho
authors.initials: NH
authors.lastname: Lee
authors.affiliation: Jeju Biodiversity Research Institute (JBRI), Jeju Technopark, Jeju 699-943, Korea ; Cosmetic Science Center, Faculty of Chemistry and Cosmetics, Jeju National University, Jeju 690-756, Korea.
authors.forename: Chang-Gu
authors.initials: CG
authors.lastname: Hyun
keywords: MITF; Undaria pinnatifida; melanin; melanogenesis; tyrosinase