title: Kidney microcirculation response to adenosine stimulation in renal artery stenosis.
abstract: The purpose of this study was to assess the vasoconstrictive effects of adenosine in the kidney microcirculation in hypertensive patients with renal artery stenosis (RAS). Twelve patients with resistant hypertension and moderate RAS were selected for the study. In all patients, systolic, diastolic and mean translesional pressure gradients, distal pressure (Pd), aortic pressure (Pa) and Pd/Pa ratio were measured using a pressure guidewire at baseline and after intrarenal bolus administration of 400 μg adenosine. We observed significant changes in mean translesional pressure gradient and systolic Pd after pharmacological stimulation. The results suggest that in hypertensive patients with RAS, vasomotor activity of the kidney microcirculation may be preserved.
authors.affiliation: Department of Cardiology, Medical University of Wrocław , Wrocław , Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Protasiewicz
authors.forename: Karol
authors.initials: K
authors.lastname: Początek
authors.forename: Maciej
authors.initials: M
authors.lastname: Podgórski
authors.forename: Rafał
authors.initials: R
authors.lastname: Poręba
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Derkacz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Gosławska
authors.forename: Wiesława
authors.initials: W
authors.lastname: Kwiatkowska
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazur
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mysiak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Januszewicz
mesh_terms: D000241:Adenosine / Q000008:administration & dosage / Q000494:pharmacology*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000241:Adenosine
keywords: Adenosine; renal artery stenosis; translesional pressure gradient