title: Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c.
abstract: OBJECTIVE
  Glucokinase monogenic diabetes (GCK-maturity-onset diabetes of the young [MODY]) should be differentiated from gestational diabetes mellitus (GDM) because management differs. New pregnancy-specific screening criteria (NSC) have been proposed to identify women who warrant GCK genetic testing. We tested NSC and HbA1c in a multiethnic GDM cohort and examined projected referrals for GCK testing.
  
  
  METHODS
  Using a GDM database, 63 of 776 women had a postpartum oral glucose tolerance test suggestive of GCK-MODY. Of these 63 women, 31 agreed to undergo GCK testing. NSC accuracy and HbA1c were examined. Projected referrals were calculated by applying the NSC to a larger GDM database (n = 4,415).
  
  
  RESULTS
  Four of 31 women were confirmed as having GCK-MODY (prevalence ∼0.5-1/100 with GDM). The NSC identified all Anglo-Celtic women but did not identify one Indian woman. The NSC will refer 6.1% of GDM cases for GCK testing, with more Asian/Indian women referred despite lower disease prevalence. Antepartum HbA1c was not higher in those with GCK-MODY.
  
  
  CONCLUSIONS
  The NSC performed well in Anglo-Celtic women. Ethnic-specific criteria should be explored.
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia vrudland@med.usyd.edu.au.
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Rudland
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Marcus
authors.initials: M
authors.lastname: Hinchcliffe
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Jason
authors.initials: J
authors.lastname: Pinner
authors.affiliation: Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Stuart
authors.initials: S
authors.lastname: Cole
authors.affiliation: Department of Medical Genomics, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Belinda
authors.initials: B
authors.lastname: Mercorella
authors.affiliation: Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Lynda
authors.initials: L
authors.lastname: Molyneaux
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Maria
authors.initials: M
authors.lastname: Constantino
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Dennis K
authors.initials: DK
authors.lastname: Yue
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Glynis P
authors.initials: GP
authors.lastname: Ross
authors.affiliation: Discipline of Medicine, The University of Sydney, Sydney, Australia Diabetes Centre, Royal Prince Alfred Hospital, Sydney, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Jencia
authors.initials: J
authors.lastname: Wong
mesh_terms: D000328:Adult; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005941:Glucokinase / Q000235:genetics*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D015995:Prevalence; D044465:White People
chemical_list: D005941:Glucokinase; D006442:Glycated Hemoglobin