title: Comparison of magnesium alloys and poly-l-lactide screws as degradable implants in a canine fracture model.
abstract: The aims of this study were to evaluate in vivo the biological responses to implants composed of biodegradable anodized WE43 (containing magnesium yttrium, rare earth elements and zirconium; Elektron SynerMag®) magnesium alloy, monolithic WE43 magnesium alloy and poly-l-lactic acid (PLLA), which are commonly used materials in clinic settings, and to evaluate the effectiveness of the materials as bone screws. The effectiveness of the magnesium alloy implants in osteosynthesis was evaluated using a bone fracture model involving the tibia of beagle dogs. For the monolithic WE43 implants, radiological, and histological evaluation revealed that bone trabeculae around the implanted monolithic WE43 decreased because of an inflammatory response. However, there was no damage due to hydrogen gas or inflammatory response in the bone tissue around the anodized WE43 implants. After 4 weeks, all the PLLA implants (n = 3) had broken but the WE43 implants had not (n = 6). These results suggest that the WE43 implants had sufficient strength to fix bone fractures at load-bearing sites in orthopedic and oral maxillofacial surgery. Therefore, these biodegradable magnesium alloys are good candidates for replacing biodegradable polymers. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1282-1289, 2016.
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. eriko.m.osur@tmd.ac.jp.
authors.forename: Eriko
authors.initials: E
authors.lastname: Marukawa
authors.affiliation: Medical Technology Research Department Medical Technology R&D Division, Olympus Corporation, 2-3 Kuboyama-cho, Hachioji, Tokyo, 192-8512, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Tamai
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hatakeyama
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Sato
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Higuchi
authors.affiliation: Medical Technology Research Department Medical Technology R&D Division, Olympus Corporation, 2-3 Kuboyama-cho, Hachioji, Tokyo, 192-8512, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakidachi
authors.affiliation: Medical Technology Research Department Medical Technology R&D Division, Olympus Corporation, 2-3 Kuboyama-cho, Hachioji, Tokyo, 192-8512, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Taniguchi
authors.affiliation: Medical Technology Research Department Medical Technology R&D Division, Olympus Corporation, 2-3 Kuboyama-cho, Hachioji, Tokyo, 192-8512, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Sakamoto
authors.affiliation: Medical Technology Research Department Medical Technology R&D Division, Olympus Corporation, 2-3 Kuboyama-cho, Hachioji, Tokyo, 192-8512, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Honda
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Omura
authors.affiliation: Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Harada
mesh_terms: D020341:Absorbable Implants; D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001863:Bone Screws; D004195:Disease Models, Animal; D004285:Dogs; D050723:Fractures, Bone / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000497:Alloys; D011091:Polyesters; C033616:poly(lactide); D008274:Magnesium
keywords: anodizing; biodegradable implants; bone screw; magnesium alloys; tibial fracture model