title: Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats.
abstract: This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Department of Animal Science, Cornell University, Ithaca, NY, 14853, USA.
authors.forename: Xingen
authors.initials: X
authors.lastname: Lei
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Zhongyao
authors.initials: Z
authors.lastname: Du
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Silu
authors.initials: S
authors.lastname: Chen
authors.affiliation: Beijing Higher Institution Engineering Research Center of Animal Product, Beijing, 100083, People's Republic of China.
authors.forename: Mingjie
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China. zhanghaocau@cau.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Beijing Laboratory of Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, P.O. Box 287, No. 17 Qinghua East Road, Haidian, Beijing, 100083, People's Republic of China.
authors.forename: Fazheng
authors.initials: F
authors.lastname: Ren
mesh_terms: D000284:Administration, Oral; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D064451:Hepcidins / Q000378:metabolism; D007501:Iron / Q000097:blood*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley
chemical_list: D005296:Ferrous Compounds; D006454:Hemoglobins; D064451:Hepcidins; D009842:Oligopeptides; C000611756:arginyl-glutamyl-glutamic acid; C073588:bis-glycino iron II; C020748:ferrous sulfate; D007501:Iron; D005998:Glycine
keywords: Hematological parameter; Hepcidin; Iron-deficiency anemia; Tripeptide iron