title: The TGF-β superfamily in dendritic cell biology.
abstract: The TGF-β superfamily consists of a large group of pleiotropic cytokines that are involved in the regulation of many developmental, physiological and pathological processes. Dendritic cells are antigen-presenting cells that play a key role in innate and adaptive immune responses. Dendritic cells have a complex relationship with the TGF-β cytokine superfamily being both source and targets for many of these cytokines. Some TGF-β family members are expressed by dendritic cells and modulate immune responses, for instance through the induction of T cell polarization. Others play a crucial role in the development and function of the different dendritic cell subsets. This review summarizes the current knowledge on the role of TGF-β family cytokines in dendritic cell biology, focusing on TGF-β as well as on other, less characterized, members of these important immune mediators.
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Pascal
authors.initials: P
authors.lastname: Seeger
authors.affiliation: Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Musso
authors.affiliation: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Humanitas Clinical and Research Institute, Rozzano, Italy. Electronic address: silvano.sozzani@unibs.it.
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
mesh_terms: D028341:Activins / Q000276:immunology / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology; D008024:Ligands; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000276:immunology* / Q000378:metabolism*
chemical_list: D019485:Bone Morphogenetic Proteins; D008024:Ligands; D016212:Transforming Growth Factor beta; D028341:Activins
keywords: Activin A; Bone morphogenetic protein; Dendritic cells; NK cells; T cells; TGF-β