title: Unusual O-alkylation of 2-hydroxy-1,4-naphthoquinone utilizing alkoxymethyl chlorides.
abstract: A new type of O-alkylation of 2-hydroxy-1,4-naphthoquinone with alkoxymethyl chlorides is described. The reaction course can be controlled by the choice of base and yields O-alkylated or O-alkoxymethylated products in high yield with high selectivity.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University.
authors.forename: Tokutaro
authors.initials: T
authors.lastname: Ogata
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Yoshida
authors.forename: Manami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Chie
authors.initials: C
authors.lastname: Fukuhara
authors.forename: Maki
authors.initials: M
authors.lastname: Shimizu
authors.forename: Junko
authors.initials: J
authors.lastname: Ishii
authors.forename: Arisa
authors.initials: A
authors.lastname: Nishiuchi
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Inamoto
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Kimachi
mesh_terms: D000478:Alkylation; D006571:Heterocyclic Compounds / Q000737:chemistry; D008738:Methyl Ethers / Q000737:chemistry; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D008738:Methyl Ethers; D009285:Naphthoquinones; C073317:chloromethyl methyl ether