title: Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis.
abstract: The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-α +489 G/A polymorphism and COPD risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under both dominant (AA+GA vs GG genotypes) and allele (A vs G) models. Heterogeneity was assessed, as well as publication bias. Nine articles with ten eligible studies were included in this analysis. Significant association between the +489 G/A polymorphism and COPD was identified in Asians under the allele model (OR = 1.582, 95%CI = 1.035-2.419). However, no significant difference was found in the Caucasian groups. Strong evidence for between-study heterogeneity was identified under both models, and no publication bias was detected. Our results indicated a potential role of the A allele of the TNF-α +489 G/A polymorphism in increasing COPD risk in Asians, but not in Caucasians. Additional studies will be necessary to verify this conclusion.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Liaoning Medical University, Jinzhou Liaoning, China.
authors.forename: K
authors.initials: K
authors.lastname: Cui
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Liaoning Medical University, Jinzhou Liaoning, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Ge
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Liaoning Medical University, Jinzhou Liaoning, China mahonglinly@163.com.
authors.forename: H L
authors.initials: HL
authors.lastname: Ma
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D014409:Tumor Necrosis Factor-alpha