title: Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex.
abstract: The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Arup
authors.initials: A
authors.lastname: Mukherjee
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Srimani
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Subrata
authors.initials: S
authors.lastname: Chakraborty
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Yehoshoa
authors.initials: Y
authors.lastname: Ben-David
authors.affiliation: Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Milstein