title: Oxidative stress in bipolar and schizophrenia patients.
abstract: Oxidative stress has an important place in studies investigating the pathophysiology of psychiatric diseases. In spite of this fact, longitudinal studies are required to clarify the subject. Therefore, in this study, we examined lipid peroxidation, protein oxidation, total oxidized guanine species, superoxide dismutase (SOD) and total glutathione (GSH) levels in blood collected from adult bipolar patients (n=18) during manic and euthymic episodes, schizophrenic patients (n=18) during acute psychotic attack and remission phases and the control group (n=18). There was a significant increase in the level of lipid peroxidation in the bipolar disorder manic episode group (BD-ME) compared to control group. The level of protein oxidation was significantly higher in the schizophrenia acute psychotic attack group (SZ-APA) compared to the control group. The level of total oxidized guanine species was statistically higher in all psychiatric groups compared to the control group. There was no significant difference among the groups with regard to SOD and GSH. Consequently, we believe that lipid peroxidation may be effective in the pathogenesis of bipolar patients; that protein oxidation may be of importance in the pathogenesis of schizophrenia and that total oxidized guanine species may be crucial in the pathogeneses of both psychiatric disorders.
authors.affiliation: Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey. Electronic address: ozgurkorhan@yahoo.com.
authors.forename: Özgür Korhan
authors.initials: ÖK
authors.lastname: Tunçel
authors.affiliation: Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Sarısoy
authors.affiliation: Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Birşen
authors.initials: B
authors.lastname: Bilgici
authors.affiliation: Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Pazvantoglu
authors.affiliation: Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Çetin
authors.affiliation: Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Ünverdi
authors.affiliation: Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Avcı
authors.affiliation: Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Böke
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Glutathione; Lipid peroxidation; Oxidized guanine; Protein oxidation; Psychiatric disorders; Superoxide dismutase