title: Combining TMS-EEG with transcranial direct current stimulation language treatment in aphasia.
abstract: Despite the fact that different studies have been performed using transcranial direct current stimulation (tDCS) in aphasia, so far, to what extent the stimulation of a cerebral region may affect the activity of anatomically connected regions remains unclear. The authors used a combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to explore brain areas' excitability modulation before and after active and sham tDCS. Six chronic aphasics underwent 3 weeks of language training coupled with tDCS over the right inferior frontal gyrus. To measure the changes induced by tDCS, TMS-EEG closed to the area stimulated with tDCS were calculated. A significant improvement after tDCS stimulation was found which was accompained by a modification of the EEG over the stimulated region.
authors.affiliation: IRCCS Fondazione Santa Lucia, Roma, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Cipollari
authors.forename: Domenica
authors.initials: D
authors.lastname: Veniero
authors.forename: Carmela
authors.initials: C
authors.lastname: Razzano
authors.forename: Carlo
authors.initials: C
authors.lastname: Caltagirone
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
authors.forename: Paola
authors.initials: P
authors.lastname: Marangolo
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001037:Aphasia / Q000503:physiopathology* / Q000628:therapy*; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007808:Language Therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology; D012660:Semantics; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome
keywords: TMS-EEG; aphasia; brain stimulation; language rehabilitation; tDCS