title: Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model.
abstract: Allergic rhinitis is one of the most common health problems and has a major effect on quality of life. Although new-generation antihistamines and nasal steroids are the main treatment options, complete resolution cannot be obtained in some patients. Besides common side effects such as nasal irritation and epistaxis, the use of these drugs is controversial in some patients, such as pregnant or breastfeeding women. These findings highlight the need for new treatment options. Although phototherapy has been successfully used in the treatment of atopic dermatitis, which is an IgE-mediated disease and shares several common pathogenic features with allergic rhinitis, there are limited studies about its role in the treatment of allergic rhinitis. In this study, we aimed to evaluate and compare the histopathological effects of intranasal phototherapy (Rhinolight) and nasal corticosteroid treatment on the nasal mucosa in allergic rhinitis in a rabbit model and we found that both treatment options significantly reduced inflammation in the nasal mucosa without increasing apoptosis of mucosal cells.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey. Electronic address: vyurttas@hotmail.com.
authors.forename: Veysel
authors.initials: V
authors.lastname: Yurttas
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Şereflican
authors.affiliation: Department of Pediatric Allergy and Immunology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Erkoçoğlu
authors.affiliation: Department of Histology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Elçin Hakan
authors.initials: EH
authors.lastname: Terzi
authors.affiliation: Department of Histology, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Kükner
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Abant Izzet Baysal University, Faculty of Medicine, Bolu, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Oral
mesh_terms: D000281:Administration, Intranasal; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D010789:Phototherapy; D011817:Rabbits; D065631:Rhinitis, Allergic / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy*
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Allergic inflammation; Allergic rhinitis; Histopathological findings; Intranasal phototherapy; Intranasal steroid treatment; Rhinolight