title: Circadian redox oscillations and metabolism.
abstract: Circadian rhythms are 24h oscillations in physiology and behavior which allow organisms to anticipate and adapt to daily demands associated with the day/night cycle. The currently accepted model of the molecular clockwork is described as a transcriptional process composed of negative regulatory feedback loops. However, ample evidence underlines the important contribution of non-transcriptional and metabolic oscillations to cellular timekeeping. We summarize recent evidence pointing to the relationship between the transcriptional oscillator and metabolic redox state, with particular emphasis on the potential nodes of interaction. We highlight the intrinsic difficulty in segregating these two tightly coupled and interdependent processes, in living systems, and how disruption of their synchronicity impacts upon (patho)physiological processes as diverse as cardiovascular and metabolic disorders, aging, and cancer.
authors.affiliation: Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, National Institute for Health Research (NIHR) Biomedical Research Centre, Wellcome Trust-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
authors.forename: Nikolay B
authors.initials: NB
authors.lastname: Milev
authors.affiliation: Department of Clinical Neurosciences, University of Cambridge Metabolic Research Laboratories, National Institute for Health Research (NIHR) Biomedical Research Centre, Wellcome Trust-Medical Research Council (MRC) Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: areddy@cantab.net.
authors.forename: Akhilesh B
authors.initials: AB
authors.lastname: Reddy
mesh_terms: D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction; D054464:Peroxiredoxins / Q000378:metabolism*
chemical_list: D054464:Peroxiredoxins
keywords: circadian rhythms; metabolism; peroxiredoxins; redox oscillations