title: Priorities and trends in the study of proteins in eye research, 1924-2014.
abstract: OBJECTIVE
  To identify the proteins that are relevant to eye research and develop assays for the study of a set of these proteins.
  
  
  METHODS
  We conducted a bibliometric analysis by merging gene lists for human and mouse from the National Center for Biotechnology Information FTP site and combining them with PubMed references that were retrieved with the search terms "eye" [MeSH Terms] OR "eye" [All Fields] OR "eyes" [All Fields].
  
  
  RESULTS
  For human and mouse eye studies, respectively, the total number of publications was 13,525 and 23,895 and the total number of proteins was 4050 and 4717. For proteins in human and mouse eye studies, respectively, 88.7 and 81.7% had five or fewer citations. The top 50 most intensively studied proteins for human and mouse eye studies were generally in the areas of photoreceptors and phototransduction, inflammation, and angiogenesis, neurodevelopment, lens transparency, and cell-cycle and cellular processes. We proposed selected reaction monitoring assays that were developed in silico for the top fifty most intensively studied proteins in human and mouse eye research.
  
  
  CONCLUSIONS
  We conclude that scientists engaged in eye research tend to focus on the same proteins. Newer resources and tools in proteomics can expand the investigations to lesser-known proteins of the eye.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
authors.affiliation: Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Maggie
authors.initials: M
authors.lastname: Lam
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Pingbo
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Center for Translational Medicine, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.|Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
authors.forename: Debra A
authors.initials: DA
authors.lastname: Schaumberg
authors.affiliation: National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.affiliation: Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Peipei
authors.initials: P
authors.lastname: Ping
authors.affiliation: Advanced Clinical BioSystems Research Institute, The Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Van Eyk
mesh_terms: D000818:Animals; D015706:Bibliometrics; D005123:Eye / Q000378:metabolism*; D006801:Humans; D051379:Mice; D040901:Proteomics / Q000706:statistics & numerical data* / Q000639:trends*; D012106:Research / Q000706:statistics & numerical data*
keywords: Biological processes; Eye; Human proteome project; MS; Mouse; Proteomics