title: Drug fever as an adverse effect of acitretin in complicated psoriasis patient.
abstract: We present a case of a 63-year old man with severe chronic plaque psoriasis and a recent history of lung cancer, wherein fever appeared suddenly after initiation of treatment with low dose acitretin. Tumor recurrence or infection was not found during extensive examinations, nevertheless the patient was empirically treated with broad-spectrum antibiotics without any effect on fever. Immediately after discontinuation of acitretin therapy, the fever disappeared. The patient was followed for next 2 years, during this period similar problems did not reappear, although there has been a relapse of psoriasis and the patient was switched later on biological treatment.
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Filip
authors.initials: F
authors.lastname: Rob
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Jorga
authors.initials: J
authors.lastname: Fialová
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Brejchová
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Džambová
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Sečníková
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Darina
authors.initials: D
authors.lastname: Zelenková
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Anna
authors.initials: A
authors.lastname: Jiráková
authors.affiliation: Dermatovenereology Department, 2nd Medical faculty, Charles University, Bulovka Hospital, Prague, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Hercogová
mesh_terms: D017255:Acitretin / Q000009:adverse effects*; D057915:Drug Substitution; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007641:Keratolytic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007641:Keratolytic Agents; D017255:Acitretin
keywords: acitretin; adverse drug reaction; drug fever; psoriasis; systemic retinoids