title: Surgical Resection of a Progressive Giant Arteriovenous Malformation After 13-year Follow-Up.
abstract: Giant arteriovenous malformation (AVM) is a complex and relatively rare congenital lesion with high morbidity and mortality. Its optimal treatment, however, remains controversial. Normal perfusion pressure breakthrough (NPPB) is a potentially devastating complication following surgical resection. Generally, strict blood pressure control is particularly recommended for preventing this phenomenon. Here we present a case of a 21-year-old patient with a progressive giant AVM who developed frequent seizures and subsequently underwent microsurgical total resection after 13-year follow-up, complicated by NPPB. Hypertensive hypervolemic treatment rather than strict blood pressure control was administrated postoperatively; however thalamic infarction occurred. During the 1 year of follow-up, the patient remained seizure-free with only mild right-sided hemiparesis.This case highlights that, in view of potential growth of the lesion, early intervention is necessary when possible. Microsurgical resection is challenging but remains to be an effective option for eliminating such giant AVM, and it is vital to keep risks associated with surgery in mind, such as NPPB. Moreover, whether blood pressure control is needed or not should be individualized.
authors.affiliation: From the Department of Neurosurgery (CF, WY, CZ, DX, DL) and Pediatrics (ZF), The Third Bethune Hospital (China-Japan Union Hospital) of Jilin University, Changchun, Jilin Province, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Fu
authors.forename: Weidong
authors.initials: W
authors.lastname: Yu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng
authors.forename: Conghai
authors.initials: C
authors.lastname: Zhao
authors.forename: Donghui
authors.initials: D
authors.lastname: Xu
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Li
mesh_terms: D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000601:surgery*; D008297:Male; D008866:Microsurgery; D019635:Neurosurgical Procedures / Q000009:adverse effects; D055815:Young Adult