title: HANS SELYE 70 YEARS LATER: STEROIDS, STRESS ULCERS & H. PYLORI.
abstract: Although Hans Selye is mostly known for his discovery & development of the stress concept, he also introduced the first physiologically sound, structure-activity classification of steroids that was also based on the chemical structure of steroids in 1943. He not only introduced the names of glucocorticoids & mineralocorticoids but discovered the anti- & pro-inflammatory properties, respectively, of these steroids in animal models. Furthermore, he not only described the first stress-induced gastric ulcers in rats (1936) & characterized the first human 'stress ulcers' during the air-raids in London during World War 11 (1943). Thus, Selye was a much more productive & creative scientist than it is generally considered.
authors.forename: Sándor
authors.initials: S
authors.lastname: Szabó
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000145:classification / Q000266:history* / Q000378:metabolism; D002908:Chronic Disease; D005756:Gastritis / Q000150:complications / Q000209:etiology / Q000266:history*; D016481:Helicobacter Infections / Q000266:history; D016480:Helicobacter pylori; D049673:History, 20th Century; D006801:Humans; D006814:Hungary; D010437:Peptic Ulcer / Q000209:etiology / Q000266:history* / Q000382:microbiology / Q000503:physiopathology; D012307:Risk Factors; D013312:Stress, Physiological; D013329:Structure-Activity Relationship; D014945:Wound Healing
chemical_list: D000305:Adrenal Cortex Hormones