title: Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors.
abstract: Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines.
authors.affiliation: Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. henry.thompson@colostate.edu.
authors.forename: Henry J
authors.initials: HJ
authors.lastname: Thompson
authors.affiliation: Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. scot.sedlacek@usoncology.com.|Rocky Mountain Cancer Centers, Denver, CO 80220, USA. scot.sedlacek@usoncology.com.
authors.forename: Scot M
authors.initials: SM
authors.lastname: Sedlacek
authors.affiliation: Colorado Biostatistics Consortium, University of Colorado, Denver, CO 80045, USA. pamela.wolfe@ucdenver.edu.
authors.forename: Pamela
authors.initials: P
authors.lastname: Wolfe
authors.affiliation: Rocky Mountain Cancer Centers, Denver, CO 80220, USA. devchand.paul@usoncology.com.
authors.forename: Devchand
authors.initials: D
authors.lastname: Paul
authors.affiliation: Department of Internal Medicine, University of Vermont, Burlington, VT 05405, USA. susan.lakoski@med.uvm.edu.
authors.forename: Susan G
authors.initials: SG
authors.lastname: Lakoski
authors.affiliation: Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. mary.playdon@yale.edu.|Department of Chronic Disease Epidemiology, Yale University, New Haven, CT 06520, USA. mary.playdon@yale.edu.
authors.forename: Mary C
authors.initials: MC
authors.lastname: Playdon
authors.affiliation: Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. john.mcginley@colostate.edu.
authors.forename: John N
authors.initials: JN
authors.lastname: McGinley
authors.affiliation: Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. scomer@rams.colostate.edu.
authors.forename: Shawna B
authors.initials: SB
authors.lastname: Matthews
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D050528:Diet, Carbohydrate-Restricted; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D050177:Overweight / Q000097:blood* / Q000150:complications / Q000178:diet therapy; D017698:Postmenopause / Q000097:blood; D011379:Prognosis; D017741:Survivors; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin
keywords: adiponectin; body composition; breast cancer survivors; dietary pattern; leptin; weight loss