title: Development of novel core-shell dual-mesoporous silica nanoparticles for the production of high bioavailable controlled-release fenofibrate tablets.
abstract: Novel core-shell dual-mesoporous silica nanoparticles (DMSN) were successfully prepared as a carrier in order to improve the dissolution of fenofibrate and obtain an oral highly bioavailable controlled-release drug delivery system using the osmotic pump technology. Fenofibrate was loaded into DMSN by an adsorption method. The solid state properties of fenofibrate in DMSN, before and after drug loading, were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption analysis (BET), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). In vitro release tests showed that DMSN increased the dissolution rate of fenofibrate and produced zero-order release in push-pull osmotic pump tablets (OPT). The relative bioavailability of OPT was 186.9% in comparison with the commercial reference product. In summary, osmotic pump technology in combination with solid dispersion technology involving nanometer materials is a promising way for achieving the oral delivery of poorly water-soluble drugs.
authors.affiliation: a Department of Pharmaceutics , Liaoning Medical University , Jinzhou , Liaoning Province , China and.
authors.forename: Zongzhe
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: b Department of Oncology , First Affiliated Hospital, Liaoning Medical University , Jinzhou , Liaoning Province , China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.affiliation: a Department of Pharmaceutics , Liaoning Medical University , Jinzhou , Liaoning Province , China and.
authors.forename: Chao
authors.initials: C
authors.lastname: Wu
authors.affiliation: a Department of Pharmaceutics , Liaoning Medical University , Jinzhou , Liaoning Province , China and.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Hao
authors.affiliation: a Department of Pharmaceutics , Liaoning Medical University , Jinzhou , Liaoning Province , China and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: a Department of Pharmaceutics , Liaoning Medical University , Jinzhou , Liaoning Province , China and.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
mesh_terms: D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004285:Dogs; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D011345:Fenofibrate / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D053758:Nanoparticles; D009995:Osmosis; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D012822:Silicon Dioxide; D011345:Fenofibrate
keywords: Controlled delivery; dissolution rate; osmotic pump; pharamcokinetics; poorly water-soluble drugs; tableting