title: Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis.
abstract: The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1βrs16944, IL8 rs4073, IL10 rs1800872, and IL10 rs1800896 was carried out using a 384-well plate format on the Sequenom MassARRAY platform. Patients with invasive Candida infections were more likely to have had an immunocompromised state, hematopoietic stem cell transplantation, solid organ transplant, solid tumor, chemotherapy within the past three months, neutropenia, surgery within the past 30 days, acute renal failure, liver failure, and/or median baseline serum creatinine. Conditional logistic regression analyses found that individuals with the rs1800896 GG genotype were associated with a higher risk of invasive Candida infections than those carrying the AA genotype (odds ratio = 0.61, 95% confidence interval = 0.37-0.94). From the results of this case-control study, we suggest that the cytokine IL-10 gene rs1800896 polymorphism might play a role in the etiology of invasive Candida infections.
authors.affiliation: Clinical Laboratory, Weihai Municipal Hospital, Weihai, China sunrongtong556@163.com.
authors.forename: R T
authors.initials: RT
authors.lastname: Sun
authors.affiliation: Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Tian
authors.affiliation: Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Xing
authors.affiliation: Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Gao
authors.affiliation: Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.
authors.forename: S B
authors.initials: SB
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000601:surgery; D000328:Adult; D000368:Aged; D000483:Alleles; D002175:Candida / Q000276:immunology / Q000472:pathogenicity; D058365:Candidiasis, Invasive / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000601:surgery; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016867:Immunocompromised Host; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D053583:Interleukin-1beta / Q000235:genetics / Q000276:immunology*; D016209:Interleukin-8 / Q000235:genetics / Q000276:immunology*; D017093:Liver Failure / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000601:surgery; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000382:microbiology / Q000601:surgery; D020641:Polymorphism, Single Nucleotide
chemical_list: C508606:CXCL8 protein, human; C508609:IL10 protein, human; D053583:Interleukin-1beta; D016209:Interleukin-8; D016753:Interleukin-10