title: The emerging role of the transcriptional coregulator RIP140 in solid tumors.
abstract: RIP140 is a transcriptional coregulator (also known as NRIP1) which plays very important physiological roles by finely tuning the activity of a large number of transcription factors. Noticeably, the RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. This short review aims to summarize the role of this transcription factor on nuclear estrogen receptors, E2F and Wnt signaling pathways based on recent observations focusing on breast, ovary, liver and colon tumors.
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Lapierre
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Docquier
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Castet-Nicolas
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Gitenay
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Stéphan
authors.initials: S
authors.lastname: Jalaguier
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Teyssier
authors.affiliation: IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.. Electronic address: vincent.cavailles@inserm.fr.
authors.forename: Vincent
authors.initials: V
authors.lastname: Cavaillès
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000378:metabolism*; D009687:Nuclear Proteins / Q000502:physiology*; D000078723:Nuclear Receptor Interacting Protein 1; D015398:Signal Transduction; D014158:Transcription, Genetic; D051153:Wnt Proteins / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004967:Estrogens; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D051153:Wnt Proteins
keywords: Breast; Cancer; Colon; Liver; NRIP1/RIP140; Nuclear signaling; Ovary