title: Meta-analysis of the diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules.
abstract: OBJECTIVE
  This meta-analysis is to evaluate the overall diagnostic yield and accuracy of electromagnetic navigation bronchoscopy (ENB)-based targeted biopsies in detecting peripheral lesions.
  
  
  METHODS
  A systematic search in PubMed was performed using "electromagnetic navigation bronchoscopy" crossed with "peripheral lesions" and "lung nodules". Test performance characteristics with the use of forest plots, summary receiver operating characteristic curves (SROCs) and bivariate random effects were summarized using Meta-Disc software. Adverse events and complications were recorded if reported.
  
  
  RESULTS
  A total of 17 studies (1,106 patients with peripheral lung lesions) were included in this analysis. The pooled sensitivity, specificity, positive likelihood ratios (PLRs), negative likelihood ratios (NLRs), and diagnostic odds ratios (DORs) of ENB was 82%, 100%, 19.36, 0.23, and 97.62, respectively. The area under the curve (AUC) for the SROC was 0.9786. No procedure-related complication was found.
  
  
  CONCLUSIONS
  ENB is an effective and safe procedure in diagnosing peripheral lung lesions.
authors.affiliation: 1 Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China ; 2 Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), Tianjin 300121, China ; 3 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; 4 Department of Hematology-Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Weisan
authors.initials: W
authors.lastname: Zhang
authors.affiliation: 1 Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China ; 2 Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), Tianjin 300121, China ; 3 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; 4 Department of Hematology-Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Chen
authors.affiliation: 1 Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China ; 2 Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), Tianjin 300121, China ; 3 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; 4 Department of Hematology-Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xifeng
authors.initials: X
authors.lastname: Dong
authors.affiliation: 1 Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin 300052, China ; 2 Department of Colorectal Surgery, Tianjin Union Medicine Center (UMC), Tianjin 300121, China ; 3 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; 4 Department of Hematology-Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lei
keywords: Electromagnetic navigation bronchoscopy (ENB); diagnostic yield; lung nodules; meta-analysis