title: The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.
abstract: The Mouse Genomes Project was initiated in 2009 with the goal of using next-generation sequencing technologies to catalogue molecular variation in the common laboratory mouse strains, and a selected set of wild-derived inbred strains. The initial sequencing and survey of sequence variation in 17 inbred strains was completed in 2011 and included comprehensive catalogue of single nucleotide polymorphisms, short insertion/deletions, larger structural variants including their fine scale architecture and landscape of transposable element variation, and genomic sites subject to post-transcriptional alteration of RNA. From this beginning, the resource has expanded significantly to include 36 fully sequenced inbred laboratory mouse strains, a refined and updated data processing pipeline, and new variation querying and data visualisation tools which are available on the project's website ( http://www.sanger.ac.uk/resources/mouse/genomes/ ). The focus of the project is now the completion of de novo assembled chromosome sequences and strain-specific gene structures for the core strains. We discuss how the assembled chromosomes will power comparative analysis, data access tools and future directions of mouse genetics.
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK. da1@sanger.ac.uk.
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK. ad19@sanger.ac.uk.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Doran
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK. jl17@sanger.ac.uk.
authors.forename: Jingtao
authors.initials: J
authors.lastname: Lilue
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK. thomas.keane@sanger.ac.uk.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Keane
mesh_terms: D000818:Animals; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics; D016678:Genome; D023281:Genomics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements