title: Serum cardiac troponin I concentrations decrease following treatment of primary immune-mediated haemolytic anaemia.
abstract: OBJECTIVE
  The measurement of serum cardiac troponin I concentrations in dogs with a range of non-primary cardiac illnesses suggests that cardiac myocyte damage is commonplace. Dogs with primary immune-mediated haemolytic anaemia have increased serum cardiac troponin I concentrations at the time of diagnosis. However, it is unclear whether biochemical evidence of cardiac myocyte damage improves following successful treatment of anaemia.
  
  
  METHODS
  A haematology profile was performed and serum cardiac troponin I concentrations were measured in 19 dogs with primary immune-mediated haemolytic anaemia before and after treatment.
  
  
  RESULTS
  The haematocrit increased significantly (P = 0 · 0001) following treatment of primary IMHA (median pre: 0 · 13 L/L, median post: 0 · 33 L/L). The serum cardiac troponin I concentrations decreased significantly (P < 0 · 05) after treatment (median pre: 0 · 26 ng/mL, median post: 0 · 16 ng/mL).
  
  
  CONCLUSIONS
  Serum cardiac troponin I concentration decreases following successful treatment of primary immune-mediated haemolytic anaemia. The clinical and prognostic significance of serum cardiac troponin I concentrations before and after treatment in dogs with primary immune-mediated haemolytic anaemia merits further investigation.
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: J A
authors.initials: JA
authors.lastname: Cartwright
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: D J
authors.initials: DJ
authors.lastname: Gow
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: A G
authors.initials: AG
authors.lastname: Gow
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: I
authors.initials: I
authors.lastname: Handel
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: N
authors.initials: N
authors.lastname: Reed
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: A J
authors.initials: AJ
authors.lastname: Brown
authors.affiliation: Rossdale & Partners, Beaufort Cottage Laboratories, Suffolk CB8 8JS.
authors.forename: R
authors.initials: R
authors.lastname: Cash
authors.affiliation: Rossdale & Partners, Beaufort Cottage Laboratories, Suffolk CB8 8JS.
authors.forename: A
authors.initials: A
authors.lastname: Foote
authors.affiliation: Parkside Veterinary Group, Dundee DD2 3PT.
authors.forename: D
authors.initials: D
authors.lastname: Mackenzie
authors.affiliation: Dick White Referrals, Station Farm, Cambridge CB8 0UH.
authors.forename: R
authors.initials: R
authors.lastname: Bell
authors.affiliation: Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mellanby
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D008297:Male; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I