title: Biomarkers of anaphylaxis, beyond tryptase.
abstract: OBJECTIVE
  The purpose of this study is to describe the current knowledge regarding mediators involved in anaphylactic reactions, with a special focus on key effector cells and mechanisms.
  
  
  RESULTS
  New insight into the potential relevance of pathways other than mast cell degranulation has been unravelled, such as the role of cytokines, platelet activation factor, lipid mediators and their metabolism or the activation of the contact system.
  
  
  CONCLUSIONS
  Gaining knowledge into these pathophysiologic mechanisms will allow researchers to pursue the identification of risk factors and new preventive and therapeutic strategies in anaphylaxis.
authors.affiliation: aAllergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron bAllergy Research Unit, Allergy Department, Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Sala-Cunill
authors.forename: Victoria
authors.initials: V
authors.lastname: Cardona
mesh_terms: D000707:Anaphylaxis / Q000097:blood / Q000276:immunology / Q000628:therapy; D015415:Biomarkers / Q000097:blood; D015550:Cell Degranulation / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D006801:Humans; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D010972:Platelet Activating Factor / Q000276:immunology / Q000378:metabolism; D012307:Risk Factors; D053802:Tryptases / Q000097:blood / Q000276:immunology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D010972:Platelet Activating Factor; D053802:Tryptases