title: Transcranial MRI-Guided Focused Ultrasound: A Review of the Technologic and Neurologic Applications.
abstract: OBJECTIVE
  This article reviews the physical principles of MRI-guided focused ultra-sound and discusses current and potential applications of this exciting technology.
  
  
  CONCLUSIONS
  MRI-guided focused ultrasound is a new minimally invasive method of targeted tissue thermal ablation that may be of use to treat central neuropathic pain, essential tremor, Parkinson tremor, and brain tumors. The system has also been used to temporarily disrupt the blood-brain barrier to allow targeted drug delivery to brain tumors.
authors.affiliation: 1 Division of Body MRI, Department of Radiology, Stanford University, Stanford, CA.
authors.forename: Pejman
authors.initials: P
authors.lastname: Ghanouni
authors.affiliation: 2 Departments of Radiology and Electrical Engineering and Bioengineering, Stanford University, Stanford, CA.
authors.forename: Kim Butts
authors.initials: KB
authors.lastname: Pauly
authors.affiliation: 3 Department of Neurosurgery, University of Virginia, Charlottesville, VA.
authors.forename: W Jeff
authors.initials: WJ
authors.lastname: Elias
authors.affiliation: 4 Department of Neurosurgery and Neurology and Neurological Sciences, Stanford University, Stanford, CA.
authors.forename: Jaimie
authors.initials: J
authors.lastname: Henderson
authors.affiliation: 3 Department of Neurosurgery, University of Virginia, Charlottesville, VA.
authors.forename: Jason
authors.initials: J
authors.lastname: Sheehan
authors.affiliation: 5 Department of Neurosurgery, Swedish Medical Center, Seattle, WA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Monteith
authors.affiliation: 6 Present address: Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Dr, Rm S047, Stanford, CA 94305-5105.
authors.forename: Max
authors.initials: M
authors.lastname: Wintermark
mesh_terms: D001927:Brain Diseases / Q000628:therapy*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D053783:Magnetic Resonance Imaging, Interventional / Q000379:methods*
keywords: MRI-guided focused ultrasound; brain; brain tumors; movement disorders; neuropathic pain; stroke