title: Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis.
abstract: Matrix metalloproteinase-3 (MMP3) plays a key role in tissue degradation in periodontitis. The relationship between the MMP3 -1171 5A/6A polymorphism (rs35068180) and periodontitis has been widely studied. However, existing studies have yielded contradictory results. We therefore conducted a meta-analysis to comprehensively investigate these inconclusive findings. Several electronic databases were searched for eligible articles. Seven case-control studies from 6 articles were searched without any language restrictions. Pooled estimates indicated that MMP3 -1171 5A/6A polymorphism is associated with a decreased risk of periodontitis (allelic genetic model: OR = 0.70, 95% CI: 0.62-0.80, P(heterogeneity) = 0.315; heterozygous model: OR = 0.50, 95% CI: 0.39-0.65, P(heterogeneity) = 0.221; homozygous model: OR = 0.42, 95% CI: 0.25-0.69, P(heterogeneity) = 0.265; dominant model: OR = 0.49, 95% CI: 0.38-0.62, P(heterogeneity) = 0.238, respectively). Similar results were also found in chronic periodontitis (CP), Asian, Asian&CP, and non-smokers subgroups. Moreover, MMP3 rs35068180 polymorphism might be associated with a lower risk of aggressive periodontitis (AgP) in Asians (allelic genetic model: OR = 0.66, 95% CI: 0.48-0.91, P(heterogeneity) = 0.945), and CP in Caucasians and Brazilians. In conclusion, this meta-analysis demonstrates that MMP3 -1171 5A/6A polymorphism may be associated with decreased risk of both CP and AgP in Asians. Large independent studies to replicate these results are necessary to validate these associations in other populations.
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ding
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Peng-tao
authors.initials: PT
authors.lastname: Zhang
authors.affiliation: Physical Examination Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
authors.forename: Jin-ping
authors.initials: JP
authors.lastname: Huang
authors.affiliation: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Hangzhou Geriatric Hospital, Hangzhou, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.affiliation: 1] Department of Stomatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China [2] School of Medicine, Hangzhou Normal University, Hangzhou, China.
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Zhong
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016208:Databases, Factual; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3