title: High Sensitive CRP Level Is Associated With Intermediate and High Syntax Score in Patients With Acute Coronary Syndrome.
abstract: High sensitive C-reactive protein (hs-CRP) levels are associated with short- and long-term mortality in patients with acute coronary syndrome (ACS). We investigated whether baseline hs-CRP levels are associated with burden of coronary atherosclerosis assessed by SYNTAX score (SXScore).We enrolled 321 patients with ACS who underwent coronary angiography. The patients were divided into tertiles according to the SXScore: low SXScore (≤ 22), and intermediate-high SXScore (≥ 23).Subjects in the intermediate-high SXScore tertile had higher serum hs-CRP levels compare to low SXScore tertile patients (7.7 ± 3.4 mg/L versus 4.9 ± 2.5 mg/L, P < 0.001). The mean age of patients and prevalance of diabetes in the intermediate-high SXScore tertile were significantly higher than in the low SXScore tertile (63 ± 13 versus 58 ± 12 years P = 0.001 for age, P = 0.007 for diabetes). Multivariate logistic regression analysis showed that the strongest predictors of high SXScore were increased serum hs-CRP levels (OR: 1.14) together with multivessel disease (OR: 0.23), left ventricular ejection fraction (LVEF) (OR: 0.90), and troponin levels (OR: 1.12).Serum hs-CRP levels on admission in patients with ACS could predict the severity and complexity of coronary atherosclerosis together with multivessel disease, LVEF, and troponin levels. Thus, increased serum levels of hs-CRP were one of the strong predictors of high SXScore in ACS patients.
authors.affiliation: Department of Cardiology, Ankara Education and Research Hospital.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Karadeniz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyel
authors.forename: Mikail
authors.initials: M
authors.lastname: Yarlıoğlueş
authors.forename: Adil Hakan
authors.initials: AH
authors.lastname: Öcek
authors.forename: İbrahim Etem
authors.initials: İE
authors.lastname: Çelik
authors.forename: Alparslan
authors.initials: A
authors.lastname: Kılıç
authors.forename: Ahmet Arif
authors.initials: AA
authors.lastname: Yalcin
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ergün
authors.forename: Sani Namık
authors.initials: SN
authors.lastname: Murat
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012107:Research Design; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012720:Severity of Illness Index; D014336:Troponin / Q000097:blood; D014421:Turkey
chemical_list: D014336:Troponin; D002097:C-Reactive Protein