title: Differences in survival outcome between stage I and stage II glottic cancer: A SEER-based analysis.
abstract: OBJECTIVE
  The purpose of this study was to investigate and compare the cause-specific survival (CSS) of stage I (tumor [T]1 node [N]0 metastasis [M]0) versus stage II (T2N0M0) glottic cancer in a large population cohort.
  
  
  METHODS
  We analyzed data from the Surveillance, Epidemiology, and End Results 18 database from 1973 to 2009, comprising patients diagnosed with T1N0M0 or T2N0M0 squamous cell glottic cancer. Kaplan-Meier survival analysis, multivariable Cox proportional hazards regression analysis, and competing-risks survival regression were used for statistical analysis.
  
  
  RESULTS
  There were 4,422 patients who met all inclusion criteria. The 36-month CSS was 93.9% for stage I verus 86.5% for stage II, with P < 0.0001. Stage II status conferred a 2.494 hazard ratio for increased risk of cause-specific death compared to stage I.
  
  
  CONCLUSIONS
  Stage II glottic cancers have a significantly worse prognosis and may need a different approach to management than stage I tumors.
  
  
  METHODS
  4.
authors.affiliation: Weill Cornell/Sloan-Kettering/Rockefeller Tri-Institutional MD-PhD Program, New York, New York, U.S.A.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Stich Radiation Center, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, U.S.A.
authors.forename: Alexander
authors.initials: A
authors.lastname: Stessin
authors.affiliation: Division of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, New York, U.S.A.
authors.forename: Paul
authors.initials: P
authors.lastname: Christos
authors.affiliation: Stich Radiation Center, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, U.S.A.
authors.forename: A Gabriella
authors.initials: AG
authors.lastname: Wernicke
authors.affiliation: Stich Radiation Center, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, U.S.A.
authors.forename: Dattatreyudu
authors.initials: D
authors.lastname: Nori
authors.affiliation: Stich Radiation Center, New York Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, U.S.A.
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Parashar
mesh_terms: D000368:Aged; D002423:Cause of Death / Q000639:trends; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018426:SEER Program; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
keywords: Glottic; SEER; T1; T2; radiation; survival