title: Anatomy of the bovine ascending aorta and brachiocephalic artery found unfavorable for total artificial heart implant.
abstract: The biocompatibility assessment of the Cleveland Clinic continuous-flow total artificial heart is an important part of the device developmental program. Surgical and postoperative management are key factors in achieving optimal outcomes. However, the presence of vascular anatomical abnormalities in experimental animal models is often unpredictable and may worsen the expected outcomes. We report a technical impediment encountered during total artificial heart implantation complicated by unfavorable bovine anatomy of the ascending aorta and brachiocephalic arterial trunk.
authors.affiliation: Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. karimoj@ccf.org.
authors.forename: Jamshid H
authors.initials: JH
authors.lastname: Karimov
authors.affiliation: Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Gengo
authors.initials: G
authors.lastname: Sunagawa
authors.affiliation: Biological Resources Unit, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Such
authors.affiliation: Department of Cardiothoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Shiva
authors.initials: S
authors.lastname: Sale
authors.affiliation: Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
authors.affiliation: Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.|Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Nader
authors.initials: N
authors.lastname: Moazami
authors.affiliation: Department of Biomedical Engineering/ND20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. fukamak@ccf.org.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology* / Q000601:surgery*; D016122:Brachiocephalic Trunk / Q000033:anatomy & histology* / Q000601:surgery*; D002417:Cattle; D006354:Heart, Artificial; D023421:Models, Animal; D019919:Prosthesis Implantation
keywords: Assisted circulation; Biocompatible materials; Cardiac surgical procedures; Models, animal; Prosthesis fitting; Pumps, heart-assist