title: Mediastinal Mature Teratoma With Malignant Carcinomatous Transformation (Somatic-Type Malignancy) With Metastatic Course.
abstract: We report the case of a 76-year-old patient presenting with an anterior mediastinal heterogeneous mass. Surgical biopsy revealed a solid and cystic lesion filled with hair. Pathological examination showed an atypical papillary epithelial lining without other germ cell tumor or immature teratoma associated. The final diagnosis was a mature teratoma of the mediastinum with somatic-type malignancy (carcinomatous transformation). After 8-month follow-up, subcutaneous and lymph node metastatic lesions of the carcinomatous component were identified. Subtyping of the malignant component within germ cell tumors is an important challenge for therapeutic options and prognosis.
authors.affiliation: University Hospital of Saint Étienne, Saint Étienne, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Habougit
authors.affiliation: University Hospital of Saint Étienne, Saint Étienne, France.
authors.forename: Violaine
authors.initials: V
authors.lastname: Yvorel
authors.affiliation: University Hospital of Saint Étienne, Saint Étienne, France.
authors.forename: Abdulrazzaq
authors.initials: A
authors.lastname: Sulaiman
authors.affiliation: Hospital of Pays de Gier, Saint Chamond, France.
authors.forename: Bachir
authors.initials: B
authors.lastname: Hag
authors.affiliation: University Hospital of Saint Étienne, Saint Étienne, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Péoc'h
authors.affiliation: University Hospital of Saint Étienne, Saint Étienne, France fabien.forest@chu-st-etienne.fr.
authors.forename: Fabien
authors.initials: F
authors.lastname: Forest
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: carcinoma; cystic tumor; germ cell tumors; germ cell tumors with somatic-type malignancy; mature mediastinal teratoma