title: Impact of early postoperative enteral nutrition on clinical outcomes in patients with gastric cancer.
abstract: The impact of early enteral nutrition (EEN) on clinical outcomes of gastric cancer patients was investigated. Three hundred pa-tients undergoing gastric cancer surgery from July 2010 to May 2014 were randomly divided into experimental and control groups (n = 150/group). Experimental group patients received enteral nutrition in water during the early postoperative period. Control group patients received conventional perioperative treatment. Patients' clinical outcomes, post-operative immune function, and nutritional statuses were compared, which revealed that the postoperative fever duration (80.2 ± 6.0 vs 88.1 ± 8.1 h, P < 0.05), anal exhaust time (78.8 ± 9.3 vs 85.3 ± 8.4 h, P < 0.05), and length of hospitalization (7.73 ± 2.13 vs 9.77 ± 1.76 days, P < 0.01) differed significantly. Treatment costs in thousands of dol-lars were 31.24 ± 3.21 for the experimental group and 35.61 ± 2.32 for the control group; this difference was statistically significant (P < 0.01). The incidence of postoperative complications did not significantly differ between the experimental and control groups [14.0% (21/150) vs 17.3% (26/150), P > 0.05]. At postoperative days 3 and 7, the CD3(+), CD4(+), natural killer cell, albumin, and prealbumin levels and CD4(+)/CD8(+) ra-tio were significantly higher in the experimental group than the control group (all P < 0.05). CD8(+) cell counts were significantly lower in the experimental group than the control group (P < 0.05). Postsurgical oral EEN can improve nutritional status and immune function and promote early recovery of intestinal function in patients with gastric cancer.
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Liu
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: S H
authors.initials: SH
authors.lastname: Guo
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: P
authors.initials: P
authors.lastname: Sun
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China.
authors.forename: F M
authors.initials: FM
authors.lastname: Gong
authors.affiliation: General Hospital of the People's Liberation Army, Beijing, China jiabaoqing1971@126.com.
authors.forename: B Q
authors.initials: BQ
authors.lastname: Jia
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D004750:Enteral Nutrition / Q000191:economics* / Q000379:methods; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007902:Length of Stay / Q000191:economics / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011228:Prealbumin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D013274:Stomach Neoplasms / Q000191:economics* / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
chemical_list: D011228:Prealbumin; D012709:Serum Albumin