title: Epidemiology and Microbiology of Sepsis Syndromes in a University-Affiliated Urban Teaching Hospital and Level-1 Trauma and Burn Center.
abstract: OBJECTIVE
  To use the 2010 to 2011 data collected by structured chart review to provide a detailed up-to-date description of the epidemiology and microbiology of the sepsis syndromes.
  
  
  METHODS
  Prospective observational study conducted at a university-affiliated urban teaching hospital and level-1 trauma and burn center. All adult patients who triggered a Code Sepsis in the emergency department (ED) between January 2010 and December 2011 were included.
  
  
  RESULTS
  One hundred eighty four patients presented with a verified sepsis syndrome and triggered a Code Sepsis in the ED during the studied time period. The mean hospital and intensive care unit length of stays (LOSs) were 15.4 (interquartile range [IQR] = 14) and 6.7 (IQR = 5) days, respectively. The total inpatient mortality was 19% (n = 35). Patients with an unspecified source of infection and those without an isolated pathogen had the highest inpatient mortality, 42.1% (n = 8) and 23.3% (n = 10), respectively.
  
  
  CONCLUSIONS
  Hospital mortality and hospital LOS of sepsis are similar to those reported in other observational studies. Our study confirms a decline in the mortality of sepsis predicted by earlier longitudinal studies and should prompt a resurgence of epidemiological research of the sepsis syndromes in the United States.
authors.affiliation: 1 Department of Medicine, University of Washington and Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
authors.forename: Luis G
authors.initials: LG
authors.lastname: Tulloch
authors.affiliation: 2 Department of Pharmacy, Harborview Medical Center, and School of Pharmacy, University of Washington, Seattle, WA, USA.
authors.forename: Jeannie D
authors.initials: JD
authors.lastname: Chan
authors.affiliation: 3 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center and School of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Carlbom
authors.affiliation: 4 Department of Nursing, Harborview Medical Center, Seattle, WA, USA.
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Kelly
authors.affiliation: 5 Division of Allergy & Infectious Diseases, Department of Medicine, Harborview Medical Center and School of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Timothy H
authors.initials: TH
authors.lastname: Dellit
authors.affiliation: 5 Division of Allergy & Infectious Diseases, Department of Medicine, Harborview Medical Center and School of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: John B
authors.initials: JB
authors.lastname: Lynch
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002053:Burn Units; D005260:Female; D017052:Hospital Mortality; D006784:Hospitals, Teaching; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018805:Sepsis / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D012720:Severity of Illness Index; D013577:Syndrome; D014193:Trauma Centers; D014861:Washington / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: epidemiology; hospital; microbiology; sepsis syndrome; septic shock; urban