title: [Genetics of dementia].
abstract: Most psychiatric diseases in adulthood have a multifactorial origin. This also applies for most cases of dementia; however, rare familial forms of Alzheimer's disease and frontotemporal lobar degeneration follow an autosomal dominant (Mendelian) inheritance pattern. Alzheimer's disease that is caused by mutations in the genes for presenilin 1, presenilin 2 and amyloid precursor protein has an onset under the age of 65 years in most cases. Approximately 10 % of frontotemporal lobar degeneration cases display an autosomal dominant inheritance pattern. According to the current S3 guidelines on dementia of the German Association for Psychiatry, Psychotherapy and Psychosomatics and the German Society of Neurology, genetic counseling should be offered if an autosomal dominant disease pattern is suspected. Genetic counseling must conform to the German Genetic Diagnostics Act (Gendiagnostikgesetz).
authors.affiliation: Klinik und Poliklinik für Psychiatrie und Psychotherapie, TU München, Ismaninger Str. 22, 81675, München, Deutschland, janine.schmid@lrz.tum.de.
authors.forename: J
authors.initials: J
authors.lastname: Diehl-Schmid
authors.forename: K
authors.initials: K
authors.lastname: Oexle
mesh_terms: D003704:Dementia / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D005817:Genetic Counseling / Q000592:standards*; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009462:Neurology / Q000592:standards*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017410:Practice Guidelines as Topic; D015995:Prevalence; D018570:Risk Assessment
chemical_list: D005819:Genetic Markers; D009419:Nerve Tissue Proteins