title: Electrocatalysis by subcellular liver fractions bound to carbon nanostructures for stereoselective green drug metabolite synthesis.
abstract: A novel, reusable, cofactor-free, and mediator-free human liver microsomal bioreactor constructed on carbon nanostructure electrodes for stereoselective green syntheses of drug metabolites and specialty chemicals is reported here for the first time. Drug metabolites are useful for examining pharmaceutical and pharmacological properties of new drugs under development.
authors.affiliation: Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, USA. gopan.krishnan@okstate.edu.
authors.forename: Rajasekhara
authors.initials: R
authors.lastname: Nerimetla
authors.forename: Sadagopan
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D019149:Bioreactors; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004566:Electrodes; D006108:Graphite / Q000737:chemistry*; D055772:Green Chemistry Technology; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008862:Microsomes, Liver / Q000378:metabolism*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D013739:Testosterone / Q000378:metabolism
chemical_list: D037742:Nanotubes, Carbon; D013739:Testosterone; D006108:Graphite; D003577:Cytochrome P-450 Enzyme System