title: Reversible Cardiomyopathy After Epirubicin Administration.
abstract: Anthracycline-containing chemotherapy can cause irreversible and progressive left ventricular dysfunction. Epirubicin, which is widely used for breast cancer chemotherapy, is an anthracycline that has less cardiac toxicity than doxorubicin. The present report describes the case of a 70-year-old woman with breast cancer who developed severe congestive heart failure and severe cardiac dysfunction at 6 weeks from epirubicin final administration. Left ventricular function gradually improved after intensive treatment for heart failure and recovered completely within 2 months. To the best of our knowledge, this is the first report to describe epirubicin-induced subacute reversible cardiotoxicity.
authors.affiliation: Department of Medicine and Biological Science, Gunma University Graduate School of Medicine.
authors.forename: Norimichi
authors.initials: N
authors.lastname: Koitabashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ohyama
authors.forename: Rieko
authors.initials: R
authors.lastname: Tateno
authors.forename: Masashi
authors.initials: M
authors.lastname: Arai
authors.forename: Nana
authors.initials: N
authors.lastname: Rokutanda
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy*; D009202:Cardiomyopathies / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D002316:Cardiotonic Agents / Q000008:administration & dosage; D004232:Diuretics / Q000008:administration & dosage*; D004280:Dobutamine / Q000008:administration & dosage*; D004452:Echocardiography; D004562:Electrocardiography; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D012121:Respiration, Artificial / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D004232:Diuretics; C472955:NPPA protein, human; D004280:Dobutamine; D015251:Epirubicin; D009320:Atrial Natriuretic Factor