title: OP0010. Optimizing time from diagnosis to delivery in preeclampsia based on the future health prospects of offspring.
abstract: BACKGROUND
  Limited data exist on long-term health-consequences of maternal preeclampsia for offspring.
  
  
  OBJECTIVE
  We investigated long-term offspring morbidity following preeclampsia and related these data to the time from diagnosis to delivery.
  
  
  METHODS
  We performed a registry based retrospective cohort study in Denmark in the years 1977-2007. The primary exposure was preeclamptic days from diagnosis to delivery. We analyzed 6 gestational age groups separately. The outcomes were groups of later disease diagnoses in offspring.
  
  
  RESULTS
  We included 758,524 singleton offspring who had accumulated 3,537,525 medical diagnoses. Offspring delivered by severely preeclamptic women between 28 and 33weeks had an increased risk of endocrine disorders (HR 1.46; 95% CI 1.09-1.96) compared to normotensive pregnancies, independent of days between diagnosis and delivery (HR 1.000; 95% CI 0.993-1.006). Offspring delivered by mildly preeclamptic women between 37 and 38 weeks had an increased risk of behavioral disorders (HR 1.19; 95% CI 1.05-1.37) and this risk was dependent on days since diagnosis (HR 1.006; 1.001-1.011). In general, after 37-38weeks, days from diagnosis to delivery increased the risk of later diagnoses in most disease groups.
  
  
  CONCLUSIONS
  Offspring from preeclamptic pregnancies have increased risks of various later diseases. The time between diagnosis and delivery modified these risks only slightly, but it seems prudent not to prolong preeclamptic pregnancies after 38weeks.
authors.forename: Jacob Alexander
authors.initials: JA
authors.lastname: Lykke
authors.forename: Jacobus J
authors.initials: JJ
authors.lastname: Boomsma
authors.forename: Birgitte
authors.initials: B
authors.lastname: Hollegaard