title: Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternal-fetal transmission, southern Thailand, 2009-2010.
abstract: Limited information is available on the seroprevalence of chikungunya virus (CHIKV) infection and maternal-fetal transmission incidence of CHIKV and dengue virus (DENV) infections during the 2008-2009 CHIKV outbreak in southern Thailand. A community-based post-epidemic seroprevalence study was conducted in parturient women admitted to the Thepa District Hospital in Songkhla Province, Thailand, for delivery from November 2009 to May 2010. The women were tested for chikungunya (CHIK) IgM/IgG and dengue (DEN) IgM/IgG. Cord blood samples were also tested for CHIK IgM or DEN IgM in women who tested positive for CHIK IgM or DEN IgM, respectively. The seroprevalence of CHIKV infection (CHIK IgM or IgG positive) was 227/319 (71·2%) with pre-outbreak seroprevalence (IgM-/IgG+) of 43·6% and the seroprevalence of DENV infection was 288/319 (90·3%). Complications during pregnancy, newborn outcomes and congenital anomalies were not different in those who had recent, remote or no CHIKV infections. None of the newborns whose mothers were CHIK or DEN IgM positive had cord blood positive for both CHIK and DEN IgM. In conclusion, both CHIKV and DENV are endemic in southern Thailand; during the recent CHIKV outbreak CHIK seroprevalence increased from 43·6% to 71·2%.
authors.affiliation: Department of Pediatrics,Faculty of Medicine,Prince of Songkla University,Hat Yai,Songkhla,Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Laoprasopwattana
authors.affiliation: Department of Obstetrics and Gynecology,Faculty of Medicine,Prince of Songkla University,Hat Yai,Songkhla,Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Suntharasaj
authors.affiliation: Thepa Hospital,Thepa District,Songkhla,Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Petmanee
authors.affiliation: Department of Pathology,Faculty of Medicine,Prince of Songkla University,Hat Yai,Songkhla,Thailand.
authors.forename: O
authors.initials: O
authors.lastname: Suddeaugrai
authors.affiliation: Epidemiology Unit,Faculty of Medicine,Prince of Songkla University,Hat Yai,Songkhla,Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Geater
mesh_terms: D000293:Adolescent; D000328:Adult; D065632:Chikungunya Fever / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D002646:Chikungunya virus / Q000302:isolation & purification; D003715:Dengue / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D015994:Incidence; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D015995:Prevalence; D016036:Seroepidemiologic Studies; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult
keywords: CHIK; chikungunya; dengue viral infection; seroprevalence