title: Enantiopure Peptide-Functionalized Metal-Organic Frameworks.
abstract: We present herein the first example of metal-organic frameworks postfunctionalized with peptides. Our microwave-assisted postsynthetic modification method yields enantiopure peptides anchored inside MOF cavities. Al-MIL-101-NH2, In-MIL-68-NH2, and Zr-UiO-66-NH2 were chosen as starting platforms. A single amino acid and various oligopeptides are grafted with yields up to 60% after a 30 min microwave-assisted coupling-deprotection sequence. This allows efficient preparation of a library of functional hybrid solids for molecular recognition applications such as sensing, separation, or asymmetric catalysis, as demonstrated here for the chiral aldol reaction.
authors.affiliation: †IRCELYON, Université Lyon 1 - CNRS, UMR 5256, 2 Avenue Albert Einstein, 69626 Villeurbanne, France.|‡C2P2, Université Lyon 1 - CPE Lyon - CNRS, UMR 5265, 43 Bvd du 11 Novembre 1918, 69616 Villeurbanne, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bonnefoy
authors.affiliation: †IRCELYON, Université Lyon 1 - CNRS, UMR 5256, 2 Avenue Albert Einstein, 69626 Villeurbanne, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Legrand
authors.affiliation: ‡C2P2, Université Lyon 1 - CPE Lyon - CNRS, UMR 5265, 43 Bvd du 11 Novembre 1918, 69616 Villeurbanne, France.
authors.forename: Elsje Alessandra
authors.initials: EA
authors.lastname: Quadrelli
authors.affiliation: †IRCELYON, Université Lyon 1 - CNRS, UMR 5256, 2 Avenue Albert Einstein, 69626 Villeurbanne, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Canivet
authors.affiliation: †IRCELYON, Université Lyon 1 - CNRS, UMR 5256, 2 Avenue Albert Einstein, 69626 Villeurbanne, France.
authors.forename: David
authors.initials: D
authors.lastname: Farrusseng
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D004151:Dipeptides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D007659:Ketones; D009942:Organometallic Compounds