title: Epicardial Adipose Tissue Is Nonlinearly Related to Anthropometric Measures and Subcutaneous Adipose Tissue.
abstract: Introduction. Adipose tissue is the largest endocrine organ, composed of subcutaneous (SAT) and visceral adipose tissue (VAT), the latter being highly associated with coronary artery disease (CAD). Expansion of epicardial adipose tissue (EAT) is linked to CAD. One way of assessing the CAD risk is with low-cost anthropometric measures, although they are inaccurate and cannot discriminate between VAT and SAT. The aim of this study is to evaluate (1) the relationship between EAT thickness, SAT thickness and anthropometric measures in a cohort of patients assessed at the cardiology unit and (2) determine predictive power of anthropometric measures and EAT and SAT thickness in establishment of CAD. Methods. Anthropometric measures were obtained from 53 CAD and 42 non-CAD patients. Vascular and structural statuses were obtained with coronarography and echocardiography, as well as measurements of the EAT and SAT thickness. Results. Anthropometric measures showed moderate positive correlation with EAT and SAT thickness. Anthropometric measures and SAT follow nonlinear S curve relationship with EAT. Strong nonlinear power curve relationship was observed between EAT and SAT thinner than 10 mm. Anthropometric measures and EAT and SAT were poor predictors of CAD. Conclusion. Anthropometric measures and SAT have nonlinear relationship with EAT. EAT thickness and anthropometric measures have similar CAD predictive value.
authors.affiliation: Department of Cardiology, Clinic of Internal Medicine, Osijek University Hospital Centre, 31000 Osijek, Croatia.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Šram
authors.affiliation: Department of Anatomy and Neuroscience, Faculty of Medicine, University of J.J. Strossmayer in Osijek, 31000 Osijek, Croatia.
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Vrselja
authors.affiliation: Department of Cardiac Surgery, Clinic of Surgery, Osijek University Hospital, 31000 Osijek, Croatia.
authors.forename: Igor
authors.initials: I
authors.lastname: Lekšan
authors.affiliation: DNA Laboratory, Department of Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of J.J. Strossmayer in Osijek, 31000 Osijek, Croatia.
authors.forename: Goran
authors.initials: G
authors.lastname: Ćurić
authors.affiliation: Department of Cardiology, Clinic of Internal Medicine, Osijek University Hospital Centre, 31000 Osijek, Croatia ; Department of Internal Medicine, Faculty of Medicine, University of J.J. Strossmayer in Osijek, 31000 Osijek, Croatia.
authors.forename: Kristina
authors.initials: K
authors.lastname: Selthofer-Relatić
authors.affiliation: Department of Anatomy and Neuroscience, Faculty of Medicine, University of J.J. Strossmayer in Osijek, 31000 Osijek, Croatia.
authors.forename: Radivoje
authors.initials: R
authors.lastname: Radić