title: The receptor proteins: pivotal roles in selective autophagy.
abstract: Autophagy is a highly regulated and multistep biological process whereby cells under metabolic, proteotoxic, or other stresses remove dysfunctional organelles and/or misfolded/polyubiquitinated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation. Although autophagy is generally considered to be a non-selective process, accumulating evidence suggests that it can also selectively degrade specific target cargoes. These selective targets include proteins, mitochondria, and even invading bacteria. The discovery and characterization of autophagic adapters, such as p62/Sequestosome 1 (SQSTM1) and Neighbor of BRCA1 gene 1 (NBR1), have provided mechanistic insights into selective autophagy. These receptors are all able to act as cargo receptors for the degradation of ubiquitinated substrates. This review mainly summarizes the most up-to-date findings regarding the key receptor proteins that play important roles in regulating selective autophagy.
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China yanglifang@csu.edu.cn.
authors.forename: Lifang
authors.initials: L
authors.lastname: Yang
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China.
authors.forename: San
authors.initials: S
authors.lastname: Xu
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China.
authors.forename: Zhibao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Cancer Research Institute, Central South University, Changsha 410078, China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, China Key Laboratory of Carcinogenesis, Ministry of Health, Changsha 410078, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Cao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D001678:Organelle Biogenesis; D011506:Proteins / Q000502:physiology*; D059748:Proteolysis; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D000071456:Sequestosome-1 Protein
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; C549756:NBR1 protein, human; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C099718:SQSTM1 protein, human; D000071456:Sequestosome-1 Protein
keywords: autophagy; receptor proteins; selective