title: Helicobacter suis-Infected Nodular Gastritis and a Review of Diagnostic Sensitivity for Helicobacter heilmannii-Like Organisms.
abstract: Helicobacter heilmannii-like organisms (HHLOs) are associated with mucosa-associated lymphoid tissue lymphoma and peptic ulcer. However, the sensitivity of diagnostic tests for HHLOs, such as rapid urease test (RUT), urea breath test (UBT) and blood antibody, is not high. Tightly coiled spiral microorganisms were found in the gastric mucosal biopsy specimen of a 48-year-old asymptomatic woman. Her findings were positive for RUT and UBT, but negative for blood antibody and stool antigen against H. pylori. A 7-day course of esomeprazole, amoxicillin and clarithromycin was administered, resulting in the successful eradication of the HHLOs. Analysis of the 16S rRNA and urease genes suggested a diagnosis of the HHLO H. suis. The sensitivity results of RUT, UBT, culture, blood antibody, immunohistochemistry and stool antigen were 40.0, 14.8, 0, 23.1, 40.0 and 0%, respectively. We report asymptomatic nodular gastritis due to an HHLO. Histological techniques, most likely with smears, are expected to be the most effective method for diagnosing infections by HHLOs, and genetic diagnosis by polymerase chain reaction can be very useful to identify the species of HHLOs.
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Goji
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tamura
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.affiliation: School of Pharmacy, Kitasato University, Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakamura
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Matsui
authors.affiliation: Laboratory of Molecular Cell Biology, School of Pharmacy, Nihon University, Funabashi, Japan.
authors.forename: Somay Yamagata
authors.initials: SY
authors.lastname: Murayama
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Ebi
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Naotaka
authors.initials: N
authors.lastname: Ogasawara
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Funaki
authors.affiliation: Department of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Kasugai
keywords: Helicobacter heilmannii-like organisms; Helicobacter suis; Rapid urease test; Stool antigen test; Urea breath test