title: Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe.
abstract: With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.
authors.affiliation: Key Laboratory for Advanced Materials & Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China. xphe@ecust.edu.cn.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Yi
authors.initials: Y
authors.lastname: Zang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.forename: Xiao-Peng
authors.initials: XP
authors.lastname: He
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Chen
authors.forename: Tony D
authors.initials: TD
authors.lastname: James
authors.forename: Jia
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D057809:HEK293 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D053644:Naphthalimides / Q000737:chemistry / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D053644:Naphthalimides; D009942:Organometallic Compounds; D014867:Water; D015032:Zinc