title: Fusariotoxins in Avian Species: Toxicokinetics, Metabolism and Persistence in Tissues.
abstract: Fusariotoxins are mycotoxins produced by different species of the genus Fusarium whose occurrence and toxicity vary considerably. Despite the fact avian species are highly exposed to fusariotoxins, the avian species are considered as resistant to their toxic effects, partly because of low absorption and rapid elimination, thereby reducing the risk of persistence of residues in tissues destined for human consumption. This review focuses on the main fusariotoxins deoxynivalenol, T-2 and HT-2 toxins, zearalenone and fumonisin B1 and B2. The key parameters used in the toxicokinetic studies are presented along with the factors responsible for their variations. Then, each toxin is analyzed separately. Results of studies conducted with radiolabelled toxins are compared with the more recent data obtained with HPLC/MS-MS detection. The metabolic pathways of deoxynivalenol, T-2 toxin, and zearalenone are described, with attention paid to the differences among the avian species. Although no metabolite of fumonisins has been reported in avian species, some differences in toxicokinetics have been observed. All the data reviewed suggest that the toxicokinetics of fusariotoxins in avian species differs from those in mammals, and that variations among the avian species themselves should be assessed.
authors.affiliation: Sciences Biologiques et Fonctionnelles, Université de Toulouse, INP, ENVT, UR Mycotoxicologie, F-31076 Toulouse, France. p.guerre@envt.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Guerre
mesh_terms: D000818:Animals; D001717:Birds; D005670:Fusarium; D006801:Humans; D009183:Mycotoxins / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D009183:Mycotoxins
keywords: T-2 toxin; avian species; deoxynivalenol; fumonisin B1; toxicokinetics; transfer; zearalenone