title: Sleep profiles in children with Down syndrome.
abstract: Down syndrome (DS) is the most common genetic cause of intellectual disability and results from an extra chromosome 21 (Trisomy 21). Sleep issues and/or obstructive sleep apnea (OSA) are assumed to be part of the DS phenotype with a high prevalence but are often under recognized. This cross-sectional study of children with DS examines the caregiver-reported sleep behaviors of 108 children with DS, ranging in age from 1.50 to 13.40 years (mean = 5.18 years) utilizing a standardized assessment tool, the Children's Sleep Habit Questionnaire (CSHQ). The CSHQ revealed 76% of children with DS had sleep problems, which began at a young age, and continue to persist and may recur with increasing age. Furthermore, children with DS who undergone adenoidectomy and tonsillectomy for OSA continued to have sleep problems suggesting that ongoing monitoring of sleep issues is needed in this population. Implications of sleep problems and recommended anticipatory guidance and intervention are discussed.
authors.affiliation: Department of Human Genetics, Emory University, Atlanta, Georgia.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Bassell
authors.affiliation: Department of Pediatrics, Emory University, Atlanta, Georgia.
authors.forename: Han
authors.initials: H
authors.lastname: Phan
authors.affiliation: Department of Pediatrics, Emory University, Atlanta, Georgia.
authors.forename: Roberta
authors.initials: R
authors.lastname: Leu
authors.affiliation: Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania.|School of Nursing, Duquesne University, Pittsburgh, Pennsylvania.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Kronk
authors.affiliation: Department of Human Genetics, Emory University, Atlanta, Georgia.|Department of Pediatrics, Emory University, Atlanta, Georgia.
authors.forename: Jeannie
authors.initials: J
authors.lastname: Visootsak
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012893:Sleep Wake Disorders / Q000150:complications*; D011795:Surveys and Questionnaires
keywords: Down syndrome; health screening; obstructive sleep apnea