title: Highly enantioselective synthesis of non-natural aliphatic α-amino acids via asymmetric hydrogenation.
abstract: By employing a rhodium-Duanphos complex as the catalyst, β-alkyl (Z)-N-acetyldehydroamino esters were smoothly hydrogenated in a highly efficient and enantioselective way. Excellent enantioselectivities together with excellent yields were achieved for a series of substrates. An efficient approach for the synthesis of the intermediate of the orally administered anti-diabetic drugs Alogliptin and Linagliptin in the DPP-4 inhibitor class was also developed.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China. xumu@whu.edu.cn huilv@whu.edu.cn.
authors.forename: Jianjian
authors.initials: J
authors.lastname: Ji
authors.forename: Caiyou
authors.initials: C
authors.lastname: Chen
authors.forename: Jiayu
authors.initials: J
authors.lastname: Cai
authors.forename: Xinrui
authors.initials: X
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Liyang
authors.initials: L
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D012238:Rhodium