title: The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques.
abstract: A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents. These probes displayed long-emission wavelengths and large Stokes shifts, as well as high affinities for Aβ aggregates. In vivo and ex vivo studies demonstrated that BBTOM-3 could intensely label Aβ plaques in the brains of transgenic mice.
authors.affiliation: Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
authors.forename: Kaixiang
authors.initials: K
authors.lastname: Zhou
authors.forename: Hualong
authors.initials: H
authors.lastname: Fu
authors.forename: Liang
authors.initials: L
authors.lastname: Feng
authors.forename: Mengchao
authors.initials: M
authors.lastname: Cui
authors.forename: Jiapei
authors.initials: J
authors.lastname: Dai
authors.forename: Boli
authors.initials: B
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D005456:Fluorescent Dyes / Q000494:pharmacology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008813:Mice, Inbred ICR; D008822:Mice, Transgenic; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000175:diagnosis* / Q000378:metabolism; D049268:Positron-Emission Tomography; D011963:Receptors, GABA-A / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D011963:Receptors, GABA-A; C030975:barbiturate receptor