title: Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential.
abstract: In the current context of antiviral drug development, which has been traditionally dominated by herpesviruses, human immunodeficiency virus (HIV) and hepatitis C virus (HCV), a new viral target has been recently gained unforeseen attention, Ebola virus. Ten nucleoside analogues, or categories thereof, are reviewed for their therapeutic potential as antiviral drugs: (i) BCX4430, a C-nucleoside; (ii) 4'-azido-, 4'-cyano-, and 4'-ethynyl derivatives; (iii) 4'-thionucleosides; (iv) cordycepin (3'-deoxyadeosine); (v) pyrazofurin, another C-nucleoside; (vi) neplanocin A analogues; (vii) EICAR, a ribavirin analogue; (viii) GR-92938X, a double carboxamide; (ix) sofosbuvir (Solvaldi(®)), a 2'-C-methylnucleoside; and (x) favipiravir (T-705), a pyrazine analogue.
authors.affiliation: Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. erik.declercq@rega.kuleuven.be.
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D003839:Deoxyadenosines / Q000737:chemistry / Q000494:pharmacology; D029043:Ebolavirus / Q000187:drug effects; D006678:HIV / Q000187:drug effects; D016174:Hepacivirus / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D011719:Pyrazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D000998:Antiviral Agents; D003839:Deoxyadenosines; D009705:Nucleosides; D011719:Pyrazines; C031096:neplanocin A; C058120:cordycepin; D000241:Adenosine