title: Statistical and Computational Methods for Genetic Diseases: An Overview.
abstract: The identification of causes of genetic diseases has been carried out by several approaches with increasing complexity. Innovation of genetic methodologies leads to the production of large amounts of data that needs the support of statistical and computational methods to be correctly processed. The aim of the paper is to provide an overview of statistical and computational methods paying attention to methods for the sequence analysis and complex diseases.
authors.affiliation: Department of Science and Technology, University of Naples Parthenope, Centro Direzionale Isola C4, 80143 Napoli, Italy.
authors.forename: Francesco
authors.identifier: 0000-0003-4439-7583
authors.initials: F
authors.lastname: Camastra
authors.affiliation: IRCCS SDN, Via E. Gianturco 113, 80143 Napoli, Italy.
authors.forename: Maria Donata
authors.initials: MD
authors.lastname: Di Taranto
authors.affiliation: Department of Science and Technology, University of Naples Parthenope, Centro Direzionale Isola C4, 80143 Napoli, Italy.
authors.forename: Antonino
authors.identifier: 0000-0002-4708-5860
authors.initials: A
authors.lastname: Staiano
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000737:chemistry; D016368:Frameshift Mutation; D017353:Gene Deletion; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D008390:Markov Chains; D015233:Models, Statistical; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012326:RNA Splicing; D012107:Research Design; D012984:Software; D013223:Statistics as Topic
chemical_list: D004247:DNA