title: The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer's disease.
abstract: OBJECTIVE
  Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model.
  
  
  METHODS
  BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies.
  
  
  RESULTS
  Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons.
  
  
  CONCLUSIONS
  Our results showed that BMSCs intratechal administration could be a promising method for treatment of Alzheimer's disease in rat model.
authors.affiliation: Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Eftekharzadeh
authors.affiliation: Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran ; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Nobakht
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Alizadeh
authors.affiliation: Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran ; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran ; Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mansooreh
authors.initials: M
authors.lastname: Soleimani
authors.affiliation: Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Hajghasem
authors.affiliation: Department of Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Kordestani Shargh
authors.affiliation: Eposcience Millennium Institute, Tehran, Iran.
authors.forename: Nushin
authors.initials: N
authors.lastname: Karkuki Osguei
authors.affiliation: Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran ; Department of Medical Genetics and Molecular Biology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Behnam
authors.affiliation: Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran ; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran ; Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Samadikuchaksaraei
keywords: Alzheimer’s disease; Bone marrow stromal cells; Intrathecal delivery; Rat model