title: Serum total antioxidant capacity status of HTLV-1 infected patients.
abstract: Many aspects of the pathogenesis of Human T-cell lymphotropic virus type 1 (HTLV-1) still need further elucidations. Previous studies have indicated that oxidative stress occurs during infection with the other retrovirus, human immunodeficiency virus 1 (HIV-1). Similar results have been observed in some other chronic viral infections including hepatitis B (HBV) and hepatitis C (HCV). In order to reveal possible oxidative stress in HTLV-1-infected patients, we evaluated serum total antioxidant capacity (TAC) as an indicator of oxidative stress in these patients. Forty-four HTLV-1-seropositive individuals were included in this study, consisting of 12 symptomatic and 32 asymptomatic (carrier) cases. Controls consisted of 36 apparently healthy, HTLV-1-, HIV- and hepatitis-seronegative individuals. All symptomatic patients had HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Serum TAC levels in patients and healthy individuals were measured using a quantitative TAC assay. The antioxidant capacity in HTLV-1-seropositive cases was significantly reduced compared to control group (P = 0.001). In addition, TAC was lower in patients with more than 5 years history of HAM/TSP compared to those with ≤5 years duration of the myelopathy (P = 0.03). Our results show a depletion of TAC during HTLV-1 infection, which intensifies along with the disease progress. This finding indicates a role of the oxidative stress in pathogenesis of HTLV-1. These results may prompt further research to evaluate any possible therapeutic effect of antioxidant dietary supplements for HTLV-1 infected individuals.
authors.forename: S
authors.initials: S
authors.lastname: Shomali
authors.forename: F Zahedi
authors.initials: FZ
authors.lastname: Avval
authors.forename: R
authors.initials: R
authors.lastname: Boostani
authors.forename: L
authors.initials: L
authors.lastname: Jarahi
authors.forename: M
authors.initials: M
authors.lastname: Youssefi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D015490:HTLV-I Infections / Q000097:blood* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry*
chemical_list: D000975:Antioxidants
keywords: HTLV-1; oxidative stress; total antioxidant capacity (TAC).