title: Reply to letter by Ferrante di Ruffano et al.: Patient outcomes in randomized comparisons of diagnostic tests are still the ultimate judge.
authors.affiliation: Department of Medicine, College of Medicine, Mayo Clinic, Rochester, MN 45110, USA.
authors.forename: Konstantinos C
authors.initials: KC
authors.lastname: Siontis
authors.affiliation: Department of Cardiology, Bern University Hospital, Freiburgstrasse 4, 3010 Bern, Switzerland.
authors.forename: George C M
authors.initials: GC
authors.lastname: Siontis
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Stanford University School of Medicine, Stanford 94305, USA; Health Policy Research, Palo Alto Medical Foundation Research Institute, Palo Alto, CA 94301, USA.
authors.forename: Despina G
authors.initials: DG
authors.lastname: Contopoulos-Ioannidis
authors.affiliation: Department of Medicine, Stanford Prevention Research Center, MSOB X306, 1265 Welch Road, Stanford, CA, USA; Department of Health Research and Policy, Stanford University, Stanford, CA 94305, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA 94305, USA. Electronic address: jioannid@stanford.edu.
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
mesh_terms: D003955:Diagnostic Tests, Routine; D006801:Humans; D063868:Patient Outcome Assessment