title: Maternal Serum Meteorin Levels and the Risk of Preeclampsia.
abstract: BACKGROUND
  Meteorin (METRN) is a recently described neutrophic factor with angiogenic properties. This is a nested case-control study in a longitudinal cohort study that describes the serum profile of METRN during different periods of gestation in healthy and preeclamptic pregnant women. Moreover, we explore the possible application of METRN as a biomarker.
  
  
  RESULTS
  Serum METRN was measured by ELISA in a longitudinal prospective cohort study in 37 healthy pregnant women, 16 mild preeclamptic women, and 20 healthy non-pregnant women during the menstrual cycle with the aim of assessing serum METRN levels and its correlations with other metabolic parameters. Immunostaining for METRN protein was performed in placenta. A multivariate logistic regression model was proposed and a classifier model was formulated for predicting preeclampsia in early and middle pregnancy. The performance in classification was evaluated using measures such as sensitivity, specificity, and the receiver operating characteristic (ROC) curve. In healthy pregnant women, serum METRN levels were significantly elevated in early pregnancy compared to middle and late pregnancy. METRN levels are significantly lower only in early pregnancy in preeclamptic women when compared to healthy pregnant women. Decision trees that did not include METRN levels in the first trimester had a reduced sensitivity of 56% in the detection of preeclamptic women, compared to a sensitivity of 69% when METRN was included.
  
  
  CONCLUSIONS
  The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia.
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: María F
authors.initials: MF
authors.lastname: Garcés
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Sanchez
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Luisa F
authors.initials: LF
authors.lastname: Cardona
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Elkin L
authors.initials: EL
authors.lastname: Simanca
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Iván
authors.initials: I
authors.lastname: González
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Luis G
authors.initials: LG
authors.lastname: Leal
authors.affiliation: Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: José A
authors.initials: JA
authors.lastname: Mora
authors.affiliation: Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Andrés
authors.initials: A
authors.lastname: Bedoya
authors.affiliation: Institute of Clinical Investigations, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Juan P
authors.initials: JP
authors.lastname: Alzate
authors.affiliation: Department of Pathology School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Ángel Y
authors.initials: ÁY
authors.lastname: Sánchez
authors.affiliation: Institute of Clinical Investigations, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Javier H
authors.initials: JH
authors.lastname: Eslava-Schmalbach
authors.affiliation: Department of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Roberto
authors.initials: R
authors.lastname: Franco-Vega
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Mario O
authors.initials: MO
authors.lastname: Parra
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Ariel I
authors.initials: AI
authors.lastname: Ruíz-Parra
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain; Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Diéguez
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain; Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Nogueiras
authors.affiliation: Department of Physiology, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Caminos
mesh_terms: D000328:Adult; D000886:Anthropometry; D016022:Case-Control Studies; D003663:Decision Trees; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D016015:Logistic Models; D009419:Nerve Tissue Proteins / Q000097:blood*; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood; D012307:Risk Factors; D055815:Young Adult
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C502097:METRN protein, human; D009419:Nerve Tissue Proteins