title: Bony non-union in a patient receiving androgen deprivation therapy for prostate cancer.
abstract: We present a case of a 76-year-old man who underwent a corrective femoral osteotomy for a varus deformity and stress fractures. The patient was on androgen deprivation therapy (ADT) for prostate cancer and the osteotomy failed to heal. At 13 months, the ADT was stopped and bony union was achieved in 3 months. Orthopaedic surgeons treating fractures in this patient population need to aware of the problems associated with ADT and closely liaise with oncologists and urologists to stop ADT or start alternative treatment until bony union has been achieved.
authors.affiliation: Peripheral Nerve Injury Unit, Royal National Orthopaedic Hospital, London, Middlesex, UK.
authors.forename: Adeel
authors.initials: A
authors.lastname: Ikram
authors.affiliation: Colchester Hospital University NHS Foundation Trust, Colchester, UK.
authors.forename: Jagwant
authors.initials: J
authors.lastname: Singh
authors.affiliation: Department of Trauma and Orthopaedics, Queens Hospital, London, UK.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ali
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D005264:Femoral Fractures / Q000601:surgery; D005593:Fracture Fixation, Internal; D015775:Fractures, Stress / Q000601:surgery; D005599:Fractures, Ununited / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010027:Osteotomy; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists