title: [The Effect of Remifentanil on the Estimated Target Effect-site Concentration (esTEC) of Propofol during Total Intravenous Anesthesia].
abstract: BACKGROUND
  Using an algorithm by which the effect-site concentration of propofol (esTEC) necessary for BIS level set from information input from BIS monitor and TCI pump is estimated, the effect of remifentanil on esTEC was investigated.
  
  
  METHODS
  In 14 abdominal/thoracic surgical patients managed under total intravenous anesthesia with propofol and remifetanil, the distribution of relation between the effect-site concentration of remifetanil and remifentanil esTEC was analyzed in a retrospective manner.
  
  
  RESULTS
  While the propofol esTEC decreased in accordance with the increase of the effect-site concentration of remifetanil, the effect-site concentration of propofol esTEC45 for maintaining BIS 45 became within a certain range and with less dispersion when the concentration of remifetanil exceeded 10 ng x ml(-1).
  
  
  CONCLUSIONS
  A mutual interaction was observed between propofol esTEC and remifetanil. For anesthetic management with less variation in BIS levels, it was considered that 10 ng x ml(-1) or higher of the effect-site concentration of remifetanil would be necessary.
authors.forename: Aya
authors.initials: A
authors.lastname: Kuroyanagi
authors.forename: Osamu
authors.initials: O
authors.lastname: Nagata
authors.forename: Akira
authors.initials: A
authors.lastname: Matsunaga
authors.forename: Takero
authors.initials: T
authors.lastname: Terashi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kanmura
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D000077208:Remifentanil; D012189:Retrospective Studies
chemical_list: D018686:Anesthetics, Intravenous; D004338:Drug Combinations; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol