title: The Spectrum of Infectious Diseases in Kidney Transplantation: A Review of the Classification, Pathogens and Clinical Manifestations.
abstract: Kidney transplantation is the treatment-of-choice for a significant number of patients with end-stage renal disease. Renal transplant recipients (RTRs) benefit from a longer life expectancy, with a better quality of life. Despite, recent accomplishments in the field of kidney transplantation, both short- and long-term, surgical and medical complications still exist. Among these complications, cardiovascular disease, carcinogenesis and infections are the most important. Infectious diseases constitute the most common complications after renal transplantation and the second most common cause of death among RTRs with a functioning graft. Theoretically, all infectious pathogens could cause disease in immunocompromised RTRs, yet among these, one could identify more important ones, such as the Enterobacteriaceae, causing urinary tract infections; pneumonia due to Pneumocystis jirovecii; Candida species which cause invasive fungal infections; herpes viruses; hepatitis viruses and parasites. Early diagnosis and effective treatment are key elements in salvaging both the allograft and the patient. However, clinical manifestations and diagnosis of such infectious diseases are not easily identified due to the altered state of immune response of the RTR. Thus, apart from possessing a deep knowledge of the etiology and the treatment options in each case, transplant physicians should also always remain alert when dealing with RTRs.
authors.affiliation: Department of Surgery, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Nikolaos-Andreas
authors.initials: NA
authors.lastname: Anastasopoulos
authors.affiliation: Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
authors.forename: Anila
authors.initials: A
authors.lastname: Duni
authors.affiliation: Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Peschos
authors.affiliation: Laboratory of Pathology, Medical School, University of Ioannina, Ioannina, Greece.
authors.forename: Niki
authors.initials: N
authors.lastname: Agnantis
authors.affiliation: Department of Nephrology, University Hospital of Ioannina, Ioannina, Greece evangeldou@gmail.com.
authors.forename: Evangelia
authors.initials: E
authors.lastname: Dounousi
mesh_terms: D002494:Central Nervous System Infections / Q000175:diagnosis / Q000209:etiology; D003141:Communicable Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D003428:Cross Infection; D005759:Gastroenteritis / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000209:etiology; D013997:Time Factors; D014184:Transplantation, Homologous
keywords: Kidney transplantation; classification; etiology; immunosuppression; infectious diseases; review