title: Strategies of Intracellular Pathogens for Obtaining Iron from the Environment.
abstract: Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed.
authors.affiliation: Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico ; Departamento de Investigación del Hospital Pediátrico de Sinaloa "Dr. Rigoberto Aguilar Pico", Boulevard Constitución S/N, Colonia Jorge Almada, 80200 Culiacán, SIN, Mexico.
authors.forename: Nidia
authors.initials: N
authors.lastname: Leon-Sicairos
authors.affiliation: Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.
authors.forename: Ruth
authors.initials: R
authors.lastname: Reyes-Cortes
authors.affiliation: Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.
authors.forename: Alma M
authors.initials: AM
authors.lastname: Guadrón-Llanos
authors.affiliation: Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Madueña-Molina
authors.affiliation: Doctorado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Avenida de las Américas y Josefa Ortiz (Ciudad Universitaria), 80030 Culiacán, SIN, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Leon-Sicairos
authors.affiliation: Unidad de Investigación de la Facultad de Medicina, Universidad Autónoma de Sinaloa, Cedros y Sauces, S/N Fracc. Fresnos, 80246 Culiacán, SIN, Mexico.
authors.forename: Adrian
authors.initials: A
authors.lastname: Canizalez-Román
mesh_terms: D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity; D060833:Cellular Microenvironment / Q000235:genetics*; D003593:Cytoplasm / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008247:Lysosomes / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology; D010587:Phagocytosis
chemical_list: D007501:Iron