title: Pteropine orthoreovirus infection among out-patients with acute upper respiratory tract infection in Malaysia.
abstract: This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates that PRV is among one of the common causative agents of acute URTI with cough and sore throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previously isolated in Malaysia. Further study is required to determine the public health significance of PRV infection in Southeast Asia, especially in cases where co-infection with other pathogens may potentially lead to different clinical outcomes.
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia.
authors.forename: Kenny
authors.initials: K
authors.lastname: Voon
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia.
authors.forename: Yeh Fong
authors.initials: YF
authors.lastname: Tan
authors.affiliation: University Tunku Abdul Rahman, Sungai Long, Selangor, Malaysia.
authors.forename: Pooi Pooi
authors.initials: PP
authors.lastname: Leong
authors.affiliation: International Medical University, Kuala Lumpur, Malaysia.
authors.forename: Cheong Lieng
authors.initials: CL
authors.lastname: Teng
authors.affiliation: Health Clinic Rembau, Negeri Sembilan, Malaysia.
authors.forename: Rajasekaran
authors.initials: R
authors.lastname: Gunnasekaran
authors.affiliation: Health Clinic Rembau, Negeri Sembilan, Malaysia.
authors.forename: Kamsiah
authors.initials: K
authors.lastname: Ujang
authors.affiliation: Temasek Lifesciences Laboratory, Singapore.
authors.forename: Kaw Bing
authors.initials: KB
authors.lastname: Chua
authors.affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D036022:Capsid Proteins / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D009960:Oropharynx / Q000821:virology; D018165:Orthoreovirus / Q000302:isolation & purification*; D010045:Outpatients; D010802:Phylogeny; D012088:Reoviridae Infections / Q000175:diagnosis* / Q000453:epidemiology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA; D013383:Suburban Population; D055815:Young Adult
chemical_list: D036022:Capsid Proteins
keywords: Kampar virus; Melaka virus; Nelson Bay virus; Pteropine orthoreovirus; Pulau virus