title: Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia.
abstract: Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.
authors.affiliation: Department of Haematology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia. jeremy.ong@svha.org.au.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Ong
authors.affiliation: Division of Haematology, SA Pathology, Adelaide, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Yeung
authors.affiliation: Department of Haematology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
authors.forename: Robin
authors.initials: R
authors.lastname: Filshie
authors.affiliation: Division of Haematology, SA Pathology, Adelaide, Australia.|University of Adelaide, South Australia, Australia.|South Australian Health and Medical Research Institute, South Australia, Australia.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Hughes
authors.affiliation: Department of Haematology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.
authors.forename: Harshal
authors.initials: H
authors.lastname: Nandurkar
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020252:Gastric Antral Vascular Ectasia / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D000068877:Imatinib Mesylate / Q000008:administration & dosage* / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000068877:Imatinib Mesylate
keywords: Chronic myeloid leukaemia; Gastric antral vascular ectasia; Imatinib; Tyrosine kinase inhibitor