title: Uric Acid as a Marker of Kidney Disease: Review of the Current Literature.
abstract: Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.
authors.affiliation: Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USA.
authors.forename: Christin
authors.initials: C
authors.lastname: Giordano
authors.affiliation: Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USA.
authors.forename: Olga
authors.initials: O
authors.lastname: Karasik
authors.affiliation: Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USA ; Orlando VA Medical Center, Orlando, FL 32827, USA.
authors.forename: Kelli
authors.initials: K
authors.lastname: King-Morris
authors.affiliation: Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USA ; Orlando VA Medical Center, Orlando, FL 32827, USA.
authors.forename: Abdo
authors.initials: A
authors.lastname: Asmar
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000378:metabolism; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D015415:Biomarkers; D014527:Uric Acid