title: Can early serum lipase measurement be routinely implemented to rule out clinically significant pancreatic fistula after pancreaticoduodenectomy?
abstract: BACKGROUND
  Postoperative pancreatic fistula (POPF) is the most significant cause of morbidity and mortality after pancreaticoduodenectomy (PD). We evaluated the role of postoperative serum lipase concentration in ruling out POPF in the immediate post-operative period.
  
  
  METHODS
  We retrospectively analysed 98 consecutive PD performed between January 2009 and December 2014, investigating the correlation between postoperative day 1 (POD1) serum lipase concentration and POPF development.
  
  
  RESULTS
  29 patients (29.5%) developed POPF [grade A, 17 (17.3%); grade B, 8 (8.1%); grade C, 4 (4%)]. A receiver operating characteristic (ROC) analysis was conducted to determine the threshold value of POD1 serum lipase associated with clinically significant POPF (AUC = 0.76, 95% CI 0.64-0.86, P = 0.01). Such threshold was ≤ 44.5 U/L and its sensitivity and specificity were 92% and 66%, respectively. The positive and negative predictive values (PPV, NPV) were 31% and 98%, respectively.
  
  
  CONCLUSIONS
  Early routinely measurement of serum lipase proved to be helpful in ruling out clinically relevant POPF (CR-POPF). In our cohort, a POD1 cut-off of ≤ 44.5 U/L allowed early and accurate identification of patients with low probability to develop clinically significant POPF, who can eventually be selected for enhanced post-operative recovery with significant clinical and economic benefits.
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: raffaele.dallavalle@unipr.it.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Dalla Valle
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: d8rmario@gmail.com.
authors.forename: Mario
authors.initials: M
authors.lastname: De Bellis
authors.affiliation: Department of Neuroscience, Parma University Hospital, Parma, Italy. Electronic address: giuseppe.pedrazzi@unipr.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pedrazzi
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: lauryna840@yahoo.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Lamecchi
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: ciorcio@hotmail.it.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bianchi
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: pellegrinocarlo@hotmail.it.
authors.forename: Carlo
authors.initials: C
authors.lastname: Pellegrino
authors.affiliation: Department of Surgery, Parma University Hospital, Parma, Italy. Electronic address: miaria@ao.pr.it.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Iaria
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects; D010185:Pancreatic Fistula / Q000175:diagnosis* / Q000209:etiology; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D008049:Lipase
keywords: Pancreatic fistula; Pancreaticoduodenectomy; Postoperative morbidity; Serum lipase