title: BRCA1 and BRCA2 mutations in Iranian breast cancer patients: A systematic review.
abstract: BACKGROUND
  BRCA1/2 genes mutation prevalence varies among ethnic groups and may be influenced by founder mutations. Understanding BRCA1/2 genes mutations is important for reducing breast cancer (BC) incidence, accurate risk assessment and counseling. This systematic review of the literature was conducted to addressing BRCA1/2 mutations in Iranian BC patients.
  
  
  METHODS
  A search for relevant articles was run on before January 2014 using MedLine, PubMed, Science Iranian Database, Google, and Web sites related to the study topic. The key words included: BC and Iran with Genes, BRCA Genes, BRCA1 and BRCA2; "Cancer Genes," and "Iran."
  
  
  RESULTS
  Thirteen articles retrieved from this search strategy were eligible for this review. The overall BRCA1 mutation rate for Iranian female BC patients was detected 31.8% (377/1183). Although this gene mutation rate for male patients is <0.01%. Eight BRCA1 mutations (c. 4837A > G, c. 3419G > A, c. 3119G > A, c. 2612C > T, c. 3113A > G, c. 2311T > C, c. 4301T > C and c. 4308T > C in BRCA1, and one BRCA2 mutation (c. 6494G > C) were found in multiple case subjects and represent candidate founder mutations.
  
  
  CONCLUSIONS
  According to these studies, there is heterogeneity in BRCA mutations in Iranian BC patients.
authors.affiliation: Department of Medical Genetics, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi Training Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Neamatzadeh
authors.affiliation: Department of General Surgery, Breast Disease Research Center, Shahid Sadoughi Training Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Seyed Mostafa
authors.initials: SM
authors.lastname: Shiryazdi
authors.affiliation: Department of Medical Genetics, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi Training Hospital, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Seyed Mahdi
authors.initials: SM
authors.lastname: Kalantar
keywords: BRCA1; BRCA2; Iran; breast cancer; familial