title: [THE TOXIC EFFECTS OF CHEMOTHERAPY ON THE GASTROINTESTINAL TRACT].
abstract: Chemotherapy in modern oncology is one of the main methods of treatment, along with surgery and radiotherapy techniques. More than 60% of patients receiving chemotherapy at different stages of treatment. Recently, modern chemotherapy has become more urgent personal approach to the choice of drugs and their doses, aimed at reducing the toxicity of chemotherapy. Complications of chemotherapy significantly degrade the effectiveness of the treatment of patients with malignant tumors, because they require lower doses of anticancer drug, or lengthening the intervals between cycles of chemotherapy, which affects treatment outcomes and quality of life.
authors.forename: L A
authors.initials: LA
authors.lastname: Sivak
authors.forename: N N
authors.initials: NN
authors.lastname: Maidanevich
authors.forename: S A
authors.initials: SA
authors.lastname: Lyalkin
authors.forename: E M
authors.initials: EM
authors.lastname: Aleksik
authors.forename: A V
authors.initials: AV
authors.lastname: Askolskiy
authors.forename: M Y
authors.initials: MY
authors.lastname: Klimanov
authors.forename: N V
authors.initials: NV
authors.lastname: Kasap
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D019468:Disease Management; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000503:physiopathology; D051549:Glutathione S-Transferase pi / Q000235:genetics; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D009154:Mutation; D057285:Precision Medicine; D011788:Quality of Life; D012307:Risk Factors; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005472:Fluorouracil