title: Comparative analysis of pulmonary and extrapulmonary tuberculosis of 411 cases.
abstract: BACKGROUND
  Tuberculosis is a disease that can involve every organ system. While pulmonary tuberculosis is the most common presentation, extrapulmonary tuberculosis (EPT) is also an important clinical problem. The current study aimed to outline and compare the demographic and clinical features of pulmonary and extrapulmonary tuberculosis cases in adults.
  
  
  METHODS
  Medical records of 411 patients (190 women, 221 men) treated between January 2010 and July 2014 in provincial tuberculosis control dispensary was retrospectively reviewed. Demographic and clinical characteristics were compared for pulmonary and extrapulmonary tuberculosis cases.
  
  
  RESULTS
  Of these 411 cases, 208 (50.6%) had pulmonary tuberculosis (PTB) and 203 were diagnosed with extrapulmonary tuberculosis (EPTB) (49.4%). The average ages for PTB and EPTB groups were 33.00-27.00 and 31.00-29.75, respectively (p = 0.513). Men were more frequently affected by PTB (59.6%), while EPTB was more commonly detected in women (52.2%) (p = 0.016). Main diagnostic modalities for PTB were sputum/smear analyses (72.7%), clinical-radiological data (21.7%) and biopsy (6.1%); while biopsy (71.5%), sputum/fluid analysis (18.8%) and clinical-radiological data (4.9%) were used for confirming EPTB (p < 0.0019). The most common sites of EPTB involvement were lymph nodes (39.4%), followed by pleura (23.6%), peritoneum (9.9%) and bone (7.4%).
  
  
  CONCLUSIONS
  Extrapulmonary involvement of tuberculosis is common and females are more likely to be affected. Increased clinical awareness is important since atypical presentations of the disease may constitute diagnostic and therapeutic challenges.
authors.affiliation: Department of Pulmonary, Yuzuncu Yil University Medical Faculty, Van, Turkey. izciaysel@mynet.com.
authors.forename: Aysel
authors.initials: A
authors.lastname: Sunnetcioglu
authors.affiliation: Medical Faculty, Department of Clinical Bacteriology and Infectious Diseases, Yuzuncu Yil University, Van, Turkey. mahmutsunnetci@hotmail.com.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sunnetcioglu
authors.affiliation: Department of Clinical Bacteriology and Infectious Disease, Ercis State Hospital, Van, Turkey. irfanbinici@hotmail.com.
authors.forename: Irfan
authors.initials: I
authors.lastname: Binici
authors.affiliation: Medical Faculty, Department of Clinical Bacteriology and Infectious Diseases, Yuzuncu Yil University, Van, Turkey. irfanbaran77@mynet.com.
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Baran
authors.affiliation: Medical Faculty, Department of Clinical Bacteriology and Infectious Diseases, Yuzuncu Yil University, Van, Turkey. mkarahoca@hotmail.com.
authors.forename: Mustafa Kasım
authors.initials: MK
authors.lastname: Karahocagil
authors.affiliation: Tuberculosis Control Dispensary, Van, Turkey. vanbhsm@gmail.com.
authors.forename: Muhammed Rıdvan
authors.initials: MR
authors.lastname: Saydan
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult