title: Protective, elective lung irradiation in non-metastatic Ewing's sarcoma.
abstract: Ewing's sarcoma in childhood is a disease from family of the peripheral primitive neuroectodermal tumours. For a period of 16 y (1984-2000), 34 children with Ewing's sarcoma were treated and followed in our department. Twenty-seven of these patients were without distant metastases. Complex treatment was applied to all these patients-chemotherapy VACA (vincristine, actinomycin D, cyclophosphamide, adriamycin), local radiotherapy to a total dose of 50-56 Gy +/- surgery. After, a local tumour control was achieved in 11 children with non-metastatic Ewing's sarcoma, elective whole lung irradiation to a total dose of 12-15 Gy was applied. Our experience in these 11 patients with non-metastatic Ewing's sarcoma, in whom elective lung irradiation was applied, showed significant reduction in the lung metastases, improved free of disease survival and overall survival. The achieved good treatment results necessitate extending this treatment approach through defining the risk groups of patients, suitable for elective lung radiotherapy combined with chemotherapy in non-metastatic Ewing's sarcoma.
authors.affiliation: Department of Radiology and Radiotherapy, Medical University, Varna, Bulgaria.
authors.forename: L
authors.initials: L
authors.lastname: Marinova
authors.affiliation: Specialized Hospital for Active Treatment in Pediatric Onco-hematology Disease, Sofia, Bulgaria.
authors.forename: I
authors.initials: I
authors.lastname: Hristozova
authors.affiliation: Department of Radiotherapy, Specialized Hospital for Active Treatment in Oncology, Sofia, Bulgaria iglika.mihaylova@abv.bg.
authors.forename: I
authors.initials: I
authors.lastname: Mihaylova
authors.affiliation: Department of Pediatric Disease, University Hospital 'Aleksandrovska', Sofia, Bulgaria.
authors.forename: P
authors.initials: P
authors.lastname: Perenovska
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide; D003609:Dactinomycin; D018572:Disease-Free Survival; D004317:Doxorubicin; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000528:radiation effects*; D009362:Neoplasm Metastasis; D011879:Radiotherapy Dosage; D012074:Remission Induction; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000532:radiotherapy*; D016896:Treatment Outcome; D014750:Vincristine
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide