title: Thirst and sodium appetite in rats with experimental nephrotic syndrome.
abstract: Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance. The present experiments investigated the role of behavioral mechanisms in contributing to disordered fluid homeostasis in rats with experimentally-induced nephrotic syndrome. The studies examined water and sodium ingestion under ad libitum conditions and in response to dehydration-related challenges in rats made nephrotic by treatment with the antibiotic, adriamycin. Rats with nephrotic syndrome had greater ad libitum water intakes beginning 3 weeks after treatment, but daily sodium (0.3M NaCl) intakes were not affected. Nephrotic rats showed attenuated water and sodium intakes after combined treatment with furosemide (10mg/kg) and captopril (2mg/kg), reduced water intakes after 20h of water deprivation, and diminished water intakes, plasma renin activity and aldosterone secretion after subcutaneous isoproterenol (30 μg/kg). However, the adriamycin-treated animals had normal water intakes in response to subcutaneous hypertonic saline (4% at 0.75 ml/100g) and central injections of angiotensin II (10, 20, and 50 ng). The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system.
authors.affiliation: Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United States.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United States; Department of Health and Human Physiology, University of Iowa, Iowa City, IA 52242-1407, United States; Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1407, United States; François M. Abboud Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, United States.
authors.forename: Alan Kim
authors.initials: AK
authors.lastname: Johnson
authors.affiliation: Department of Psychological brain sciences, University of Iowa, Iowa City, IA 52242-1407, United States; François M. Abboud Cardiovascular Center, University of Iowa, Iowa City, IA 52242-1407, United States. Electronic address: robert-thunhorst@uiowa.edu.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Thunhorst
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D004195:Disease Models, Animal; D004232:Diuretics / Q000494:pharmacology; D004317:Doxorubicin / Q000633:toxicity; D004326:Drinking / Q000187:drug effects; D005665:Furosemide / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009404:Nephrotic Syndrome / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism*; D013894:Thirst / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D001993:Bronchodilator Agents; D004232:Diuretics; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D005665:Furosemide; D004317:Doxorubicin; D002216:Captopril; D012964:Sodium; D012083:Renin; D007545:Isoproterenol
keywords: Adriamycin; Aldosterone; Angiotensin II; Captopril; Furosemide; Isoproterenol; Plasma renin activity; Vasopressin