title: Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins.
abstract: A series of novel chiral phosphoramidite ligands based on chiral-bridged biphenyl backbones have been prepared conveniently and characterized. The ligands complexed with [IrCodCl]2 provided the first iridium catalyst system for the asymmetric addition of arylboronic acids to N-protected isatins with high efficiency. When performed in THF/H2O at 80 °C with 2 equiv of the arylboronic acids, the transformations acquired good to excellent results (up to 98% yield and 95% ee).
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Yuwei
authors.initials: Y
authors.lastname: He
authors.forename: Zihong
authors.initials: Z
authors.lastname: Zhou
authors.forename: Wang
authors.initials: W
authors.lastname: Xia
authors.forename: Chuyu
authors.initials: C
authors.lastname: Cheng
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: §Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Jiyan
authors.initials: J
authors.lastname: Pang
authors.affiliation: ‡Huizhou Research Institute of Sun Yat-sen University, Dayawan, Huizhou 516000, People's Republic of China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Qiu
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium; D007510:Isatin / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D008024:Ligands; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D007495:Iridium; D007510:Isatin