title: Genetic polymorphisms in the carbonic anhydrase VI gene and dental caries susceptibility.
abstract: We investigated the role of 7 single nucleotide polymorphisms in the carbonic anhydrase (CA) VI gene (rs2274328, rs17032907, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186) and the possible association between these polymorphisms and dental caries susceptibility in a Northwestern Chinese population. We collected samples from 164 high caries experience and 191 very low caries experience and conducted a case-control study according to the number of decayed, missing, and filled teeth index and genotyped the 7 polymorphisms using a 384-well plate format with the Sequenom MassARRAY platform. Individuals carrying the rs17032907 TT genotype were more likely to have an increased risk of dental caries compared with carriers of the C/C genotype in the co-dominant model, with an odds ratio (95% confidence interval) of 2.144 (1.096-4.195). We also found that the haplotype (ACA) (rs2274328, rs17032907 and rs11576766) was associated with a low number of decayed, missing, and filled teeth index with an odds ratio (95% confidence interval) of 0.635 (0.440-0.918). However, we found no association between dental caries susceptibility and the rs2274328, rs11576766, rs2274333, rs10864376, rs3765964, and rs6680186 polymorphisms and other haplotypes. The rs17032907 genetic variant and the haplotype (ACA) of CA VI may be associated with dental caries susceptibility.
authors.affiliation: School of Stomatology, Northwest University for Nationalities, Lanzhou, Gansu, China.
authors.forename: Z-Q
authors.initials: ZQ
authors.lastname: Li
authors.affiliation: School of Stomatology, Northwest University for Nationalities, Lanzhou, Gansu, China.
authors.forename: X-P
authors.initials: XP
authors.lastname: Hu
authors.affiliation: School of Stomatology, Northwest University for Nationalities, Lanzhou, Gansu, China.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Zhou
authors.affiliation: Institute of Genetic Research, Lanzhou University, Lanzhou, Gansu, China.
authors.forename: X-D
authors.initials: XD
authors.lastname: Xie
authors.affiliation: School of Life Sciences, Jinggangshan University, Ji'an, Jiangxi Province, China.
authors.forename: J-M
authors.initials: JM
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002256:Carbonic Anhydrases / Q000235:genetics*; D003731:Dental Caries / Q000235:genetics*; D003733:Dental Caries Susceptibility / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D002256:Carbonic Anhydrases; C477051:carbonic anhydrase VI