title: Results of Primary Cytoreductive Surgery in Advanced-stage Epithelial Ovarian Cancer: A Single-center Experience.
abstract: OBJECTIVE
  To determine the impact of maximal cytoreductive surgery on overall survival in advanced epithelial ovarian cancer.
  
  
  METHODS
  We retrospectively reviewed medical data of patients submitted to primary cytoreductive surgery for advanced epithelial cancer in the Fundeni Clinical Hospital between 1 January 2002 and 1 April 2014.
  
  
  RESULTS
  A total of 338 patients were eligible for the study. Complete cytoreduction was achieved in 242 patients and was associated with a significantly improved survival (p<0.001), when compared to patients in whom incomplete debulking surgery was performed. Other prognostic factors associated with an improved survival were stage by the International Federation of Gynecology and Obstetrics and the preoperative biological status of the patient.
  
  
  CONCLUSIONS
  A more extensive surgical approach is perfectly justified and associated with improved survival in patients with advanced-stage epithelial ovarian cancer. However, patient selection should be performed carefully because the general preoperative status can significantly impact survival.
authors.affiliation: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania nicolae_bacalbasa@yahoo.ro.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Bacalbasa
authors.affiliation: Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Dima
authors.affiliation: Ponderas Hospital, Bucharest, Romania.
authors.forename: Irina
authors.initials: I
authors.lastname: Balescu
authors.affiliation: Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Leonard
authors.initials: L
authors.lastname: David
authors.affiliation: Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Vladislav
authors.initials: V
authors.lastname: Brasoveanu
authors.affiliation: Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Irinel
authors.initials: I
authors.lastname: Popescu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077216:Carcinoma, Ovarian Epithelial; D065426:Cytoreduction Surgical Procedures / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: Epithelial ovarian cancer; complete cytoreduction; multivisceral resection; overall survival