title: Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance.
abstract: In order to progress beyond currently available medical devices and implants, the concept of tissue engineering has moved into the centre of biomedical research worldwide. The aim of this approach is not to replace damaged tissue with an implant or device but rather to prompt the patient's own tissue to enact a regenerative response by using a tissue-engineered construct to assemble new functional and healthy tissue. More recently, it has been suggested that the combination of Synthetic Biology and translational tissue-engineering techniques could enhance the field of personalized medicine, not only from a regenerative medicine perspective, but also to provide frontier technologies for building and transforming the research landscape in the field of in vitro and in vivo disease models.
authors.affiliation: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Brisbane, Australia; George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA 30332, USA; Institute for Advanced Study, Technical University Munich, Lichtenbergstraße 2a, 85748 Garching, Munich, Germany. Electronic address: dietmar.hutmacher@qut.edu.au.
authors.forename: Dietmar Werner
authors.initials: DW
authors.lastname: Hutmacher
authors.affiliation: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Brisbane, Australia; Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072 Wuerzburg, Germany.
authors.forename: Boris Michael
authors.initials: BM
authors.lastname: Holzapfel
authors.affiliation: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Brisbane, Australia; Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Elena Maria
authors.initials: EM
authors.lastname: De-Juan-Pardo
authors.affiliation: Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Brooke Anne
authors.initials: BA
authors.lastname: Pereira
authors.affiliation: Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Stuart John
authors.initials: SJ
authors.lastname: Ellem
authors.affiliation: Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Brisbane, Australia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Loessner
authors.affiliation: Prostate Cancer Research Group, Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Gail Petuna
authors.initials: GP
authors.lastname: Risbridger
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D057285:Precision Medicine; D019736:Prostheses and Implants; D044968:Regenerative Medicine / Q000379:methods*; D058615:Synthetic Biology / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods