title: Antioxidant and genotoxic properties of Maytenus dasyclada: a comparative study in relation to Maytenus reference species.
abstract: In these work the in vitro antioxidant activity and the in vivo genotoxicity of M. dasyclada was compared to the reference species M. aquifolium and M. ilicifolia. M. dasyclada showed in vitro antioxidant activity comparable to M. aquifolium but lower than M. ilicifolia, being that a inverse Pearson correlation between DPPH IC50 values and total phenolic content was detected (-0.932). The carbonyl content of M. dasyclada and M. aquifolium extracts promoted a similar increase in protein oxidation in vivo, while M. ilicifolia no altered the carbonyl levels. The comet assay demonstrated that the three analyzed species promoted a low and similar level of genotoxicity; which is compatible with DNA damage induced by other medicinal plants and is partially recovered by a co-treatment with vitamin C. The data showed M. dasyclada as antioxidant activity in vitro, and that its genotoxic and pro-oxidant effects in vivo are comparable to the Maytenus reference species.
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: R L
authors.initials: RL
authors.lastname: Cansian
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: G B
authors.initials: GB
authors.lastname: Kubiak
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Borsatti
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: A A
authors.initials: AA
authors.lastname: Mielniczki-Pereira
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: S S
authors.initials: SS
authors.lastname: Roman
authors.affiliation: Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Paroul
authors.affiliation: Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Schwanz
authors.affiliation: Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Manfredini
authors.affiliation: Universidade Federal da Fronteira Sul, Erechim, RS, Brazil.
authors.forename: A J
authors.initials: AJ
authors.lastname: Mossi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D020552:Comet Assay; D008297:Male; D029755:Maytenus / Q000737:chemistry* / Q000145:classification / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification / Q000633:toxicity; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D010936:Plant Extracts