title: Sublingual vein parameters, AFP, AFP-L3, and GP73 in patients with hepatocellular carcinoma.
abstract: This study evaluated the diagnostic value of alpha-fetoprotein (AFP), AFP heterogeneity 3 (AFP-L3), Golgi protein 73 (GP73), and sublingual vein parameters in hepatocellular carcinoma (HCC). Levels of serum AFP, AFP-L3, GP73, and sublingual vein scores were measured in 34 patients with chronic hepatitis, 65 patients with post-hepatitis B cirrhosis, 71 patients with HCC, and 6 healthy controls. Logistic regression analysis was used to explore potential correlations. Sublingual vein grades in patients with HCC were higher than those in the other three groups; sublingual vein scores were also different between groups; combined diagnosis using AFP, GP73, and sublingual vein grade was superior to the individual parameters alone or when only two were used in different combinations. Thus, sublingual vein grade can be considered as an independent risk factor for diagnosis of HCC. Furthermore, combined detection with AFP, GP73, and sublingual vein grade is simple, inexpensive, and effective. It may therefore be suitable for screening high-risk populations for early diagnosis of HCC.
authors.affiliation: Tianjin Second People's Hospital, Tianjin, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Tianjin Second People's Hospital, Tianjin, China.
authors.forename: L-Y
authors.initials: LY
authors.lastname: Guo
authors.affiliation: Tianjin Second People's Hospital, Tianjin, China.
authors.forename: J-M
authors.initials: JM
authors.lastname: Yang
authors.affiliation: Tianjin Second People's Hospital, Tianjin, China zhaojvvip@163.com.
authors.forename: J-W
authors.initials: JW
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D005260:Female; D015870:Gene Expression; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D009060:Mouth Floor / Q000098:blood supply / Q000473:pathology; D020033:Protein Isoforms / Q000097:blood / Q000235:genetics; D012307:Risk Factors; D014680:Veins / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C097353:AFP protein, human; D014408:Biomarkers, Tumor; C410824:GOLM1 protein, human; D008565:Membrane Proteins; D020033:Protein Isoforms; D000509:alpha-Fetoproteins