title: PP076. Oscillation of blood pressure seen in eclamptic women.
abstract: BACKGROUND
  It was found that eclampsia might be caused by vasogenic edema as a result of breaking autoregulation of cerebral blood flow. The finding of PRES (posterior reversible encephalopathy syndrome) was seen on MRI (T2 FLAIR) in eclamptic women. PRES was also seen in women complicated by severe hypertension. Therefore, severity of hypertension might depend on the onset of eclampsia in pregnant women. However, it remains to be unclear with other factors except severity.
  
  
  OBJECTIVE
  In the present study, we estimated the pathophysiological mechanisms focusing on changes of blood pressure in preeclamptic women.
  
  
  METHODS
  From May to December 2011, 5 eclamptic women were present in Nagoya City West Medical center (795 pregnant women, including 22 preeclamptic women). Four of preeclamptic women developed eclampsia. We recorded changing blood pressure and analyzed them for 4 days (before and after 2 days).
  
  
  RESULTS
  Three were severe hypertension (more than 160/110mmHg) before 2days. Just before, all showed wide-oscillation of blood pressure (more than 30/15mmHg). One was severe preeclampsia in 37weeks of gestation. After cesarean section, blood pressure was decreasing (100/50mmHg), due to blood loss. Taking blood transfusion, blood pressure subsequently increased and disease occurred. Double product, which means a working index of heart function was low and was in turn low after it. Furthermore, shock index, which means a blood volume was upset.
  
  
  CONCLUSIONS
  From these results, it was suggested that a wide-difference of blood pressure might induce elampsia in women complicated by preeclampsia.
authors.affiliation: Obstetrics and Gynecology, Nagoya City West Medical Center, Nagoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Obstetrics and Gynecology, Nagoya City West Medical Center, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsuura
authors.affiliation: Pharmacology, Nagoya City University, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto