title: Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin.
abstract: Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine. Histological analysis of the skin also revealed that EPJ treatment significantly decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment was accompanied by a decrease in the skin levels of type 2 helper T-cell cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased in the skin by EPJ. Nuclear translocation of nuclear factor-κB p65 was decreased by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the AD-like skin lesions was restored by EPJ treatment. These results suggested that EPJ may be a potential therapeutic tool for the treatment of AD.
authors.affiliation: 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Gabsik
authors.initials: G
authors.lastname: Yang
authors.affiliation: 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Se-Yun
authors.initials: SY
authors.lastname: Cheon
authors.affiliation: 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Kyung-Sook
authors.initials: KS
authors.lastname: Chung
authors.affiliation: 2 Department of Oriental Ophthalmology, Otolaryngology, and Dermatology Medicine, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: 2 Department of Oriental Ophthalmology, Otolaryngology, and Dermatology Medicine, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Chul-Hee
authors.initials: CH
authors.lastname: Hong
authors.affiliation: 3 Department of Pharmaceutical Biochemistry, Kyung Hee University , Seoul, Korea.|4 Department of Life and Nanopharmaceutical Science, Kyung Hee University , Seoul, Korea.
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.affiliation: 4 Department of Life and Nanopharmaceutical Science, Kyung Hee University , Seoul, Korea.
authors.forename: Dae-Sik
authors.initials: DS
authors.lastname: Jang
authors.affiliation: 5 Highland Agriculture Research Center, National Institute of Crop Science , Rural Development Administration, Gangwon, Korea.
authors.forename: Jin-Cheol
authors.initials: JC
authors.lastname: Jeong
authors.affiliation: 5 Highland Agriculture Research Center, National Institute of Crop Science , Rural Development Administration, Gangwon, Korea.
authors.forename: Oh-Keun
authors.initials: OK
authors.lastname: Kwon
authors.affiliation: 5 Highland Agriculture Research Center, National Institute of Crop Science , Rural Development Administration, Gangwon, Korea.
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Nam
authors.affiliation: 1 Department of Oriental Pharmacology, College of Oriental Medicine, Sangji University , Gangwon, Korea.
authors.forename: Hyo-Jin
authors.initials: HJ
authors.lastname: An
mesh_terms: D000818:Animals; D000941:Antigens; D016207:Cytokines / Q000097:blood; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008925:Mites; D008517:Phytotherapy; D019441:Plant Epidermis; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011198:Solanum tuberosum / Q000737:chemistry*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D058408:Th1-Th2 Balance / Q000187:drug effects*; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D000941:Antigens; D016207:Cytokines; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D010936:Plant Extracts; D059808:Polyphenols
keywords: IgE; NF-κB; Solanum tuberosum L. cv Jayoung; Th2; atopic dermatitis