title: Correlation of spectral-domain optical coherence tomography with fundus fluorescein angiography in an infant with retinal hamartomas.
abstract: OBJECTIVE
  To describe the correlation between the surface morphology on spectral-domain optical coherence tomography (SD-OCT) and leakage pattern on fundus fluorescein angiography (FFA) in an infant with multiple retinal hamartomas.
  
  
  METHODS
  An Asian Indian female infant was found to have 2 retinal lesions in the right eye and 1 in the left eye during Retcam (Clarity MSI, CA, USA) screening for retinopathy of prematurity at 45 weeks postmenstrual age. Spectral-domain optical coherence tomography on the hand-held OCT (Envisu 2300, Bioptigen, NC, USA) and FFA on the Retcam 3 were performed under monitoring in the office.
  
  
  RESULTS
  Spectral-domain OCT detected all 3 lesions but only 1 lesion was detected on FFA. While this lesion had an irregular surface with overlying vitreoretinal (VR) traction on SD-OCT, the other 2 lesions not detected on FFA were smooth and had no VR traction. After a follow-up to 18 months corrected age, there was no change in the morphology of any of the lesions.
  
  
  CONCLUSIONS
  It is possible to characterize retinal hamartomas in infants using SD-OCT and correlate them with FFA. Spectral-domain OCT examination can be used to diagnose and monitor lesions even if they are not detectable on angiography.
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Chidambara
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Shwetha
authors.initials: S
authors.lastname: Mangalesh
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Munusamy
authors.initials: M
authors.lastname: Sivakumar
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Bhujang
authors.initials: B
authors.lastname: Shetty
authors.affiliation: From the Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore - India.
authors.forename: Anand
authors.initials: A
authors.lastname: Vinekar
mesh_terms: D002199:Capillary Permeability; D005260:Female; D005451:Fluorescein Angiography; D005865:Gestational Age; D006223:Hamartoma Syndrome, Multiple / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D015997:Neonatal Screening; D013508:Ophthalmologic Surgical Procedures; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014402:Tuberous Sclerosis / Q000175:diagnosis