title: EEG background features that predict outcome in term neonates with hypoxic ischaemic encephalopathy: A structured review.
abstract: OBJECTIVE
  Hypoxic ischaemic encephalopathy is a significant cause of mortality and morbidity in the term infant. Electroencephalography (EEG) is a useful tool in the assessment of newborns with HIE. This systematic review of published literature identifies those background features of EEG in term neonates with HIE that best predict neurodevelopmental outcome.
  
  
  METHODS
  A literature search was conducted using the PubMed, EMBASE and CINAHL databases from January 1960 to April 2014. Studies included in the review described recorded EEG background features, neurodevelopmental outcomes at a minimum age of 12 months and were published in English. Pooled sensitivities and specificities of EEG background features were calculated and meta-analyses were performed for each background feature.
  
  
  RESULTS
  Of the 860 articles generated by the initial search strategy, 52 studies were identified as potentially relevant. Twenty-one studies were excluded as they did not distinguish between different abnormal background features, leaving 31 studies from which data were extracted for the meta-analysis. The most promising neonatal EEG features are: burst suppression (sensitivity 0.87 [95% CI (0.78-0.92)]; specificity 0.82 [95% CI (0.72-0.88)]), low voltage (sensitivity 0.92 [95% CI (0.72-0.97)]; specificity 0.99 [95% CI (0.88-1.0)]), and flat trace (sensitivity 0.78 [95% CI (0.58-0.91)]; specificity 0.99 [95% CI (0.88-1.0)]).
  
  
  CONCLUSIONS
  Burst suppression, low voltage and flat trace in the EEG of term neonates with HIE most accurately predict long term neurodevelopmental outcome.
  
  
  CONCLUSIONS
  This structured review and meta-analysis provides quality evidence of the background EEG features that best predict neurodevelopmental outcome.
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia; The University of Queensland, Perinatal Research Centre, School of Medicine, Brisbane, Australia. Electronic address: m.awal@uq.edu.au.
authors.forename: Md Abdul
authors.initials: MA
authors.lastname: Awal
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia; The University of Queensland, Perinatal Research Centre, School of Medicine, Brisbane, Australia.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Lai
authors.affiliation: Department of Electrical Engineering, Razi University, Kermanshah, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Azemi
authors.affiliation: College of Engineering, Qatar University, Qatar; The University of Queensland, Perinatal Research Centre, School of Medicine, Brisbane, Australia; The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia.
authors.forename: Boualem
authors.initials: B
authors.lastname: Boashash
authors.affiliation: The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia; The University of Queensland, Perinatal Research Centre, School of Medicine, Brisbane, Australia.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Colditz
mesh_terms: D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D007223:Infant; D007231:Infant, Newborn; D011237:Predictive Value of Tests; D047929:Term Birth / Q000502:physiology*; D016896:Treatment Outcome
keywords: Background features; EEG; HIE; Hypothermia; Meta-analysis; Neurodevelopmental outcome; Newborn; Structured review