title: Acetate-Derived Metabolites from the Brown Alga Lobophora variegata.
abstract: Seven new nonadecaketides (1-7), lobophorols A-C, lobophopyranones A and B, and lobophorones A and B, along with the first naturally occurring related metabolites (8-10), were isolated from specimens of Lobophora variegata collected from the Canary Islands. Their structures were determined by extensive spectroscopic methods. In addition, an insight into the biosynthesis of these compounds on the basis of the involvement of type III polyketide synthases is proposed. Lobophorol A (1) showed significant antibacterial activity against Staphylococcus aureus.
authors.affiliation: †Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands (CIBICAN), Department of Organic Chemistry, University of La Laguna, 38206 La Laguna, Tenerife, Spain.
authors.forename: Adrián
authors.initials: A
authors.lastname: Gutiérrez-Cepeda
authors.affiliation: †Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands (CIBICAN), Department of Organic Chemistry, University of La Laguna, 38206 La Laguna, Tenerife, Spain.
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
authors.affiliation: †Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands (CIBICAN), Department of Organic Chemistry, University of La Laguna, 38206 La Laguna, Tenerife, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Norte
authors.affiliation: §Centre for Drug Research, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland.
authors.forename: Sofia
authors.initials: S
authors.lastname: Montalvão
authors.affiliation: §Centre for Drug Research, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Tammela
authors.affiliation: †Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands (CIBICAN), Department of Organic Chemistry, University of La Laguna, 38206 La Laguna, Tenerife, Spain.
authors.forename: María L
authors.initials: ML
authors.lastname: Souto
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D000459:Phaeophyceae / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013030:Spain; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D061065:Polyketides; C000602214:lobophorol A