title: Pyrido[1,2-a]pyrimidinium ions--a novel bridgehead nitrogen heterocycles: synthesis, characterisation, and elucidation of DNA binding and cell imaging properties.
abstract: A novel class of bridgehead nitrogen heterocycles, pyrido[1,2-a]pyrimidinium ions, has been readily synthesized by a two-step one-pot reaction in high yields (up to 93%). These ionic compounds are bench stable and moisture tolerant and have highly fluorescent properties (quantum yield up to 0.65). A characteristic bright bluish fluorescence was observed in polar solvents such as acetonitrile and fluorescent intensity gradually diminishes with decreasing the polarity of the medium, which becomes almost negligible in toluene. These compounds also show interesting bioactivity. DNA interaction, imaging, and viability experiments with human leukemic Jurkat and KG-1A cells revealed that they are potential candidates for cancer diagnosis.
authors.affiliation: Department of Chemistry, Haldia Government College, Haldia 721657, India. smanna19@gmail.com mbaidya@iitm.ac.in hossainm@mail.vidyasagar.ac.in.
authors.forename: Susanta Kumar
authors.initials: SK
authors.lastname: Manna
authors.forename: Arabinda
authors.initials: A
authors.lastname: Mandal
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Mondal
authors.forename: Arup Kr
authors.initials: AK
authors.lastname: Adak
authors.forename: Akash
authors.initials: A
authors.lastname: Jana
authors.forename: Somnath
authors.initials: S
authors.lastname: Das
authors.forename: Sourav
authors.initials: S
authors.lastname: Chattopadhyay
authors.forename: Somenath
authors.initials: S
authors.lastname: Roy
authors.forename: Shyamal Kr
authors.initials: SK
authors.lastname: Ghorai
authors.forename: Shubhankar
authors.initials: S
authors.lastname: Samanta
authors.forename: Maidul
authors.initials: M
authors.lastname: Hossain
authors.forename: Mahiuddin
authors.initials: M
authors.lastname: Baidya
mesh_terms: D000818:Animals; D002151:Calorimetry; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007477:Ions; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D057054:Molecular Imaging / Q000379:methods*; D009584:Nitrogen / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D006571:Heterocyclic Compounds; D007477:Ions; D011725:Pyridines; D011743:Pyrimidines; D017382:Reactive Oxygen Species; D012997:Solvents; D004247:DNA; C427203:calf thymus DNA; D007770:L-Lactate Dehydrogenase; C030986:pyrimidine; D009584:Nitrogen