title: Self-assembled microbubbles as contrast agents for ultrasound/magnetic resonance dual-modality imaging.
abstract: In this work, superparamagnetic self-assembled microbubbles (SAMBs) consisting of "Poly(acrylic acid)-Iron oxide nanoparticles-Polyamine" sandwich-like shells and tetradecafluorohexane cores were fabricated by a template-free self-assembly approach. The SAMBs exhibit not only magnetic resonance (MR) T2 imaging functionality, but also ultrasound (US) image contrast, showing great potential as US/MR dual contrast agents. The diameters of the SAMBs can be tuned easily from 450nm to 1300nm by changing the precursor ratio, and this size variation directly affects their in vitro MRI and US signals. The SAMBs also exhibit in vivo contrast enhancement capabilities in rat liver with injection through portal vein, for both MR and US imaging. Additionally, the biodistribution of SAMBs over time suggests normal systemic metabolic activity through the spleen. The results show that the Fe content in rat liver reduces to a level of which Fe cannot be detected in 45days. The SAMBs exhibit no obvious damage to the primary organs of rat during the metabolic process, indicating their good biocompatibility in vivo.
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Song
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Heze
authors.initials: H
authors.lastname: Guo
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
authors.forename: Zequan
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, PR China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Ultrasound, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Neoplasms and Interventional Radiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: An
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, PR China. Electronic address: zzf555@sina.com.
authors.forename: Zhaofeng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: ksun@sjtu.edu.cn.
authors.forename: Kang
authors.initials: K
authors.lastname: Sun
authors.affiliation: The State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: hjdou@sjtu.edu.cn.
authors.forename: Hongjing
authors.initials: H
authors.lastname: Dou
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008099:Liver / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D045423:Microbubbles; D053758:Nanoparticles; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D014463:Ultrasonography / Q000379:methods*
chemical_list: D000180:Acrylic Resins; D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; C006903:carbopol 940
keywords: Magnetic resonance imaging; Microbubbles; Self-assembly; Ultrasound imaging