title: Long-term functional airway assessment after open airway surgery for laryngotracheal stenosis.
abstract: OBJECTIVE
  The purpose of this study was to evaluate our patient-reported and objective long-term outcomes of patients treated for laryngotracheal stenosis.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Sixty-five patients were evaluated after a median follow-up of 7 years after surgery. Follow-up measurements consisted of pulmonary function testing, Bruce treadmill test, and Child Health Questionnaires (CHQ).
  
  
  RESULTS
  Pulmonary function tests were available in 43 patients, and 30/43 had abnormal forced expiratory volume in 1 second/forced inspiratory volume in 1 second (FIV1), 25/43 had abnormal FIV1/maximum vital capacity, and 24/43 had abnormal peak expiratory flow. One-third of patients had reduced exercise tolerance. CHQ revealed significant positive correlations with pulmonary function results and exercise tolerance. Multivariate analysis showed that glottic involvement of the stenosis and the presence of comorbidities at time of surgery are the only factors for poor long-term functional outcome.
  
  
  CONCLUSIONS
  The majority of patients show deficits in pulmonary function and exercise tolerance related to lower scores of quality of life. Glottic involvement of the stenosis and the presence of comorbidities are the only significant factors for poor functional outcome. Long-term multidisciplinary follow up is mandatory after surgery for laryngotracheal stenosis.
  
  
  METHODS
  2B.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Bas
authors.initials: B
authors.lastname: Pullens
authors.affiliation: Department of Pediatrics, Pediatric Pulmonology, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Marielle W
authors.initials: MW
authors.lastname: Pijnenburg
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Hoeve
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Baatenburg de Jong
authors.affiliation: Department of Pediatrics, Intensive Care Unit, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Corinne M P
authors.initials: CM
authors.lastname: Buysse
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Marieke K
authors.initials: MK
authors.lastname: Timmerman
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Marc P
authors.initials: MP
authors.lastname: van der Schroeff
authors.affiliation: Department of Pediatrics, Intensive Care Unit, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Koen F M
authors.initials: KF
authors.lastname: Joosten
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D007829:Laryngostenosis / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011446:Prospective Studies; D011788:Quality of Life; D012129:Respiratory Function Tests; D013997:Time Factors; D014135:Tracheal Stenosis / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Laryngotracheal stenosis; children; cricotracheal resection; functional outcome; laryngotracheal reconstruction; surgical results