title: [Polycystic ovary syndrome (PCOS) and gestational diabetes mellitus (GDM) risk].
abstract: Gestational diabetes mellitus (GDM) is a common complication of pregnancy In the course of pregnancy elevated levels of hormones and other proteins having insulin-antagonistic effects lead to higher insulin resistance in peripheral tissues, followed by hyperinsulinemia. Risk factors for the development of GDM have been well-established. However, the debate whether polycystic ovary syndrome (PCOS) may predispose to GDM continues. Patients with PCOS are often affected by obesity dyslipidemia, hyperinsulinemia, and tissue-specific insulin resistance. Obesity occurs in 50% of the cases, while tissue-specific insulin resistance is observed in 20-40% of the affected patients. This paper aims at systematizing risk factors that could contribute to the development of GDM, as well as reviewing literature reports and analyses on the occurrence of a potential correlation.
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Issat
authors.forename: Małgorzata A
authors.initials: MA
authors.lastname: Nowicka
authors.forename: Artur J
authors.initials: AJ
authors.lastname: Jakimiuk
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D015984:Causality; D015897:Comorbidity; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000453:epidemiology*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D001786:Blood Glucose