title: Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease.
abstract: Benign paroxysmal positional vertigo (BPPV) is one of the most frequently encountered primary complaints in dizziness clinics. The incidence of BPPV has been proven to increase with age. The relationship between BPPV and another neurodegenerative disease, Parkinson's disease (PD), has not been previously discussed. This study aimed to investigate the relationship of BPPV and PD with oxidative stress. A total of 30,811 subjects participated in our cohort study. The study cohort comprised 5057 BPPV patients and a comparison cohort of 25,754 nonBPPV patients. SIRT1 axis gene expression was investigated in BPPV patient blood samples and a PD cell model of 6-hydroxydopamine (6-OHDA)-treated PC-12 cells to elucidate the potential in vitro and in vivo mechanisms of degeneration in PD and BPPV. Our data suggest that BPPV patients with histories of head injuries show a significantly higher hazard to develop subsequent PD (hazard ratio, 3.942; confidence interval, 1.523-10.205, p = 0.005). We also observed that oxidative status is increased in blood samples from patients with BPPV. Our in vitro study suggests that SIRT1 function is inhibited by oxidative stress, which thereby promotes 6-hydroxydopamine-induced cell death. We conclude that BPPV is independently associated with an increased risk of PD. This finding may be attributed to oxidative stress-mediated inhibition of SIRT1 expression levels.
authors.affiliation: Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Kun-Ling
authors.initials: KL
authors.lastname: Tsai
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Yuan-Yang
authors.initials: YY
authors.lastname: Cheng
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Hsin-Bang
authors.initials: HB
authors.lastname: Leu
authors.affiliation: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yi-Yen
authors.initials: YY
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Tzeng-Ji
authors.initials: TJ
authors.lastname: Chen
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Ding-Hao
authors.initials: DH
authors.lastname: Liu
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: clkao@vghtpe.gov.tw.
authors.forename: Chung-Lan
authors.initials: CL
authors.lastname: Kao
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D065635:Benign Paroxysmal Positional Vertigo / Q000097:blood* / Q000453:epidemiology*; D002867:Chromones / Q000494:pharmacology; D015331:Cohort Studies; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics*; D016627:Oxidopamine / Q000494:pharmacology; D016716:PC12 Cells / Q000187:drug effects; D010300:Parkinson Disease / Q000097:blood / Q000453:epidemiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D056564:Sirtuin 1 / Q000097:blood* / Q000235:genetics; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D018663:Adrenergic Agents; D002867:Chromones; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D014157:Transcription Factors; D051028:bcl-2-Associated X Protein; C474269:eryvarin F; D016627:Oxidopamine; D020932:Nerve Growth Factor; D013482:Superoxide Dismutase; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: Benign paroxysmal positional vertigo; Oxidative stress; Parkinson's disease; SIRT1