title: Death Receptor Expression on Blasts in AML Is Associated with Unfavorable Prognosis.
abstract: BACKGROUND
  Tumor necrosis factor (TNF) receptor family members play a key role in the regulation of biological functions such as differentiation, proliferation and apoptosis of various cell types.
  
  
  METHODS
  We studied co-expression profiles of death receptors from the TNF family [TNF-related apoptosis-inducing ligand receptor (TRAILR) 1 to 3, TNF receptor 1 (TNFR1) and FAS receptor (FAS)] on peripheral blood blasts from 46 patients with acute myeloid leukemia (AML) at first diagnosis by flow cytometry and correlated the obtained specific fluorescence indices (SFI) with morphological, cytogenetic and clinical parameters.
  
  
  RESULTS
  We found that the expression of TRAILR2 and R3 was significantly increased in unfavorable risk groups, according to the National Comprehensive Cancer Network. Additionally, cut-off analyses for TRAILR2 and TNFR1 showed significantly shorter overall survival, earlier disease onset, higher proportions of cases with unfavorable prognosis and higher probability of relapse when SFIs were above the established cut-off.
  
  
  CONCLUSIONS
  We demonstrate that high co-expression of death receptors on blasts is an independent predictor of poor prognosis in AML.
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany.
authors.forename: Joerg Uwe
authors.initials: JU
authors.lastname: Schmohl
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, Partner site Tübingen, Department for Internal Medicine II, Eberhard Karls University Tübingen, Germany.
authors.forename: Tina
authors.initials: T
authors.lastname: Nuebling
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, Partner site Tübingen, Department for Internal Medicine II, Eberhard Karls University Tübingen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Wild
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Jung
authors.affiliation: Medical Department 3, Department for Hematopoetic Cell Transplantations, University Hospital of Munich, Munich, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Kroell
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Kanz
authors.affiliation: Medical Department 2, Department for Hematology and Hemato-oncology, University Hospital of Tübingen, Tübingen, Germany Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, Partner site Tübingen, Department for Internal Medicine II, Eberhard Karls University Tübingen, Germany.
authors.forename: Helmut R
authors.initials: HR
authors.lastname: Salih
authors.affiliation: Medical Department 3, Department for Hematopoetic Cell Transplantations, University Hospital of Munich, Munich, Germany Helga.Schmetzer@med.uni-muenchen.de.
authors.forename: Helga
authors.initials: H
authors.lastname: Schmetzer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D053218:Receptors, Death Domain / Q000378:metabolism*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism; D053319:Tumor Necrosis Factor Decoy Receptors / Q000378:metabolism; D055815:Young Adult; D019014:fas Receptor / Q000378:metabolism
chemical_list: D053218:Receptors, Death Domain; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D019014:fas Receptor
keywords: Acute myeloid leukemia; FAS; TNFR1; TRAILR; death receptors