title: Treatment of psoriasis and psoriatic arthritis during pregnancy and breastfeeding.
abstract: Psoriasis is a chronic inflammatory disease that affects primarily the skin and joints, with a worldwide incidence of 2-3%. Fifty percent of patients are women, most still diagnosed during childbearing years. Currently,the estimate is that up to 107 thousand deliveries are performed annually in women with psoriasis, a percentage of them in women with moderate to severe disease. Fetal risks in pregnant women with psoriasis derive both from maternal disease and the medications used to control the illness. The purpose of this review is to study the effect of the main drugs used in the treatment of psoriasis and psoriatic arthritis during pregnancy and lactation, with particular focus on disease-modifying anti-rheumatic biological drugs, biological therapies, immunobiologics or biologics.
authors.affiliation: Hospital das Forças Armadas, Brasília, DF, Brazil.
authors.forename: Patricia Shu
authors.initials: PS
authors.lastname: Kurizky
authors.affiliation: Hospital Regional da Ceilândia, Ceilândia, DF, Brazil.
authors.forename: Clarissa de Castro
authors.initials: Cde C
authors.lastname: Ferreira
authors.affiliation: aff04, Brazil.
authors.forename: Lucas Souza Carmo
authors.initials: LS
authors.lastname: Nogueira
authors.affiliation: Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Licia Maria Henrique da
authors.initials: LM
authors.lastname: Mota
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D018501:Antirheumatic Agents / Q000009:adverse effects; D015535:Arthritis, Psoriatic / Q000188:drug therapy*; D001942:Breast Feeding; D003879:Dermatologic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects; D007774:Lactation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011565:Psoriasis / Q000188:drug therapy*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D018501:Antirheumatic Agents; D003879:Dermatologic Agents; D007155:Immunologic Factors; D014409:Tumor Necrosis Factor-alpha