title: Cilia: Organelles at the Heart of Heart Disease.
abstract: Genetic disorders, such as heterotaxy, first provided a link between cilia and developmental heart defects. Now, a genetic screen in mice shows that ciliary dysfunction may indeed be the major contributing factor in the etiology of congenital heart disease.
authors.affiliation: Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673.
authors.forename: Vijay
authors.initials: V
authors.lastname: Narasimhan
authors.affiliation: Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore; Department of Pediatrics, National University of Singapore, 1E Kent Ridge Drive, Singapore. Electronic address: sudipto@imcb.a-star.edu.sg.
authors.forename: Sudipto
authors.initials: S
authors.lastname: Roy
mesh_terms: D000818:Animals; D002925:Ciliary Motility Disorders / Q000150:complications*; D004252:DNA Mutational Analysis; D006330:Heart Defects, Congenital / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008954:Models, Biological; D025941:Protein Interaction Mapping; D015398:Signal Transduction / Q000502:physiology*