title: α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments.
abstract: The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.
authors.affiliation: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors.forename: Ayala
authors.initials: A
authors.lastname: Lampel
authors.forename: Efrat
authors.initials: E
authors.lastname: Elis
authors.forename: Tom
authors.initials: T
authors.lastname: Guterman
authors.forename: Sharon
authors.initials: S
authors.lastname: Shapira
authors.forename: Pini
authors.initials: P
authors.lastname: Marco
authors.forename: Eran
authors.initials: E
authors.lastname: Bacharach
authors.forename: Ehud
authors.initials: E
authors.lastname: Gazit
mesh_terms: D000621:Aminoisobutyric Acids / Q000737:chemistry / Q000494:pharmacology*; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D036022:Capsid Proteins / Q000737:chemistry / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000494:pharmacology*; D057809:HEK293 Cells; D015497:HIV-1; D006801:Humans; D011487:Protein Conformation
chemical_list: D000621:Aminoisobutyric Acids; D019380:Anti-HIV Agents; D036022:Capsid Proteins; D057846:Cell-Penetrating Peptides; C100049:2-aminoisobutyric acid