title: Proteomic analysis of colon and rectal carcinoma using standard and customized databases.
abstract: Understanding proteomic differences underlying the different phenotypic classes of colon and rectal carcinoma is important and may eventually lead to a better assessment of clinical behavior of these cancers. We here present a comprehensive description of the proteomic data obtained from 90 colon and rectal carcinomas previously subjected to genomic analysis by The Cancer Genome Atlas (TCGA). Here, the primary instrument files and derived secondary data files are compiled and presented in forms that will allow further analyses of the biology of colon and rectal carcinoma. We also discuss new challenges in processing these large proteomic datasets for relevant proteins and protein variants.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine , Nashville, TN 37232, USA ; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center , Nashville, TN 37232, USA.
authors.forename: Robbert J C
authors.initials: RJ
authors.lastname: Slebos
authors.affiliation: Department of Mathematical Sciences, University of Cincinnati , Cincinnati, OH 45221, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
authors.forename: Xaojing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Informatics, Vanderbilt University School of Medicine , Nashville, TN 37232, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Tabb
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine , Nashville, TN 37232, USA ; Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center , Nashville, TN 37232, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
mesh_terms: D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism; D030562:Databases, Protein; D001330:Electronic Data Processing; D006801:Humans; D040901:Proteomics; D012004:Rectal Neoplasms / Q000235:genetics / Q000378:metabolism