title: The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner.
abstract: OBJECTIVE
  The chemokine receptor CXCR7 is found on glioma cells and glioma-associated vessels and dependent upon its localisation on tumour or endothelial cells the CXCR7 receptor can mediate glioma cell invasion and tumour angiogenesis. Its expression predicts survival in several types of cancers.
  
  
  METHODS
  We immunohistochemically studied the expression of CXCR7 and its ligand SDF1α in a cohort of 354 human patients with glioma. In an in vivo glioma model, we studied the effect of selective CXCR7 inhibition on mean vascular density.
  
  
  RESULTS
  Here we show that expression of either mutant isocitrate dehydrogenase (IDH) 1 or podoplanin (PDPN), two proteins present in basically non-overlapping glioma populations, predicts the prognostic significance of CXCR7. Specifically, expression of CXCR7 on endothelial cells in IDH1 mutant cases predicted poor outcome. Surprisingly, in PDPN expressing gliomas, one of the marker genes for the recently identified mesenchymal subgroup, expression of CXCR7 predicts diminished prognosis on tumour cells and better prognosis on endothelial cells.
  
  
  CONCLUSIONS
  Since CXCR7 is expressed on migrating cells our data suggest that, although ubiquitously present, angiogenesis and invasion are outcome-relevant events in specific glioma subgroups, providing a potentially important tool for targeted therapy assignment.
authors.affiliation: Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Birner
authors.affiliation: Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Andrey
authors.initials: A
authors.lastname: Tchorbanov
authors.affiliation: Department of Neuropathology, St. Ivan Rilski Hospital, Sofia, Bulgaria.
authors.forename: Sevdalin
authors.initials: S
authors.lastname: Natchev
authors.affiliation: Department of Neurosurgery, Klinikum Idar-Oberstein, Idar-Oberstein, Germany.
authors.forename: Jochen
authors.initials: J
authors.lastname: Tuettenberg
authors.affiliation: Department of Neurosurgery, Klinikum Idar-Oberstein, Idar-Oberstein, Germany.
authors.forename: Marin
authors.initials: M
authors.lastname: Guentchev
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D054377:Chemokine CXCL12 / Q000378:metabolism; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D053208:Kaplan-Meier Estimate; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D016513:Mice, SCID; D008875:Middle Aged; D009154:Mutation; D009361:Neoplasm Invasiveness; D018919:Neovascularization, Physiologic; D011379:Prognosis; D016016:Proportional Hazards Models; D054387:Receptors, CXCR / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D013997:Time Factors; D023041:Xenograft Model Antitumor Assays; D000098853:Podoplanin
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D054377:Chemokine CXCL12; D007521:Isocitrate Dehydrogenase; D008562:Membrane Glycoproteins; D054387:Receptors, CXCR; C501896:ACKR3 protein, human; C515255:CXCL12 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin; C543588:IDH1 protein, human
keywords: BRAIN TUMOURS; NEOPLASMS; NEURO-ONCOLOGY; NEUROPATHOLOGY