title: Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions.
abstract: We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups.
authors.affiliation: Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France. brun_elodie@hotmail.com.
authors.forename: Elodie
authors.initials: E
authors.lastname: Brun
authors.affiliation: LSOA-Laboratoire de Synthèse Organique Appliquée, Department of chemistry, Oran 1 University, 1524 Oran, Algeria. asafer2001@yahoo.fr.
authors.forename: Abdelmounaim
authors.initials: A
authors.lastname: Safer
authors.affiliation: Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France. francois.carreaux@univ-rennes1.fr.
authors.forename: François
authors.initials: F
authors.lastname: Carreaux
authors.affiliation: Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France. bkhadije@yahoo.fr.
authors.forename: Khadidja
authors.initials: K
authors.lastname: Bourahla
authors.affiliation: Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France. jm.lhelgoualch@gmail.com.
authors.forename: Jean-Martial
authors.initials: JM
authors.lastname: L'helgoua'ch
authors.affiliation: Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France. jean-pierre.bazureau@univ-rennes1.fr.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bazureau
authors.affiliation: Villapharma Research, Parque Tecnologico de Fuente Alamo, E-30320 Murcia, Spain. jmvillalgordo@villapharma.com.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Villalgordo
mesh_terms: D000098:Acetophenones / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D001888:Boric Acids / Q000737:chemistry*; D002384:Catalysis; D055772:Green Chemistry Technology; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D008872:Microwaves; D012997:Solvents / Q000737:chemistry
chemical_list: D000098:Acetophenones; D000447:Aldehydes; D001888:Boric Acids; D012997:Solvents; C030011:carbene; D008697:Methane; C032688:boric acid; C038699:acetophenone
keywords: boric acid; catalysis; condensation reaction; microwave; solvent-free