title: [(11)C]CO2 to [(11)C]CO conversion mediated by [(11)C]silanes: a novel route for [(11)C]carbonylation reactions.
abstract: A novel chemical methodology is described for the conversion of [(11)C]CO2 to [(11)C]CO. Diphenylmethyl silanes trap [(11)C]CO2 and release [(11)C]CO rapidly when triggered by TBAF. Released [(11)C]CO was used to produce [(11)C]N-benzylbenzamide and AMPA receptor ligand, [(11)C], in radiochemical yields >90% within 6 min from [(11)C]CO2 production.
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London, SE1 7EH, UK. antony.gee@kcl.ac.uk.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Taddei
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London, SE1 7EH, UK. antony.gee@kcl.ac.uk.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Bongarzone
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London, SE1 7EH, UK. antony.gee@kcl.ac.uk.
authors.forename: Abdul Karim
authors.initials: AK
authors.lastname: Haji Dheere
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, King's College London, 4th Floor Lambeth Wing, London, SE1 7EH, UK. antony.gee@kcl.ac.uk.
authors.forename: Antony D
authors.initials: AD
authors.lastname: Gee
mesh_terms: D002245:Carbon Dioxide / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D002250:Carbon Radioisotopes; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*
chemical_list: D002250:Carbon Radioisotopes; D012821:Silanes; D002245:Carbon Dioxide; D002248:Carbon Monoxide