title: Management of intestinal bleeding with single-dose cyclophosphamide in Henoch-Schönlein purpura.
abstract: In these case series, we report on six children (3 girls, 3 boys) aged 5-13 years with Henoch-Schönlein purpura (HSP) who developed severe gastrointestinal (GI) bleeding resistant to both 2 mg/kg or pulse (10-30 mg/kg) i.v. methylprednisolone. All patients responded to single-dose (500 mg/m(2) ) i.v. cyclophosphamide (CPA) and none of them developed new GI bleeding after CPA treatment. No patients required surgical intervention. Single high-dose CPA may be beneficial in HSP with severe GI involvement, in which bleeding is non-responsive to high-dose steroids.
authors.affiliation: Departments of Pediatrics.
authors.forename: Ünal
authors.initials: Ü
authors.lastname: Uluca
authors.affiliation: Departments of Pediatric Rheumatology, Dicley University Medical School, Diyarbakir, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Ece
authors.affiliation: Departments of Pediatrics.
authors.forename: Velat
authors.initials: V
authors.lastname: Şen
authors.affiliation: Departments of Pediatrics.
authors.forename: Servet
authors.initials: S
authors.lastname: Yel
authors.affiliation: Departments of Pediatrics.
authors.forename: İlhan
authors.initials: İ
authors.lastname: Tan
authors.affiliation: Departments of Pediatrics.
authors.forename: Duran
authors.initials: D
authors.lastname: Karabel
mesh_terms: D000293:Adolescent; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
keywords: Henoch-Schönlein purpura; cyclophosphamide; gastrointestinal bleeding; steroid; treatment