title: Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer.
abstract: OBJECTIVE
  We have previously reported an approach to ovarian stimulation for the purpose of fertility preservation (FP) in women with breast cancer via embryo freezing with the concurrent use of letrozole. The aim of this study was to provide the pregnancy and FP outcomes when embryos generated with the same protocol are used.
  
  
  METHODS
  In all, 131 women with stage ≤ 3 breast cancer underwent ovarian stimulation and received concurrent letrozole 5 mg per day before receiving adjuvant chemotherapy and cryopreserving embryos.
  
  
  RESULTS
  Thirty-three of the 131 women underwent 40 attempts to transfer embryos to their own uterus (n = 18) or via the use of a gestational carrier (n = 22) at a mean age of 41.5 ± 4.3 years with a median 5.25 years after embryo cryopreservation. The overall live birth rate per embryo transfer was similar to the US national mean among infertile women of a similar age undergoing in vitro fertilization-embryo transfer (45.0 v 38.2; P = .2). Seven (38.8%) of the 18 pregnancies were twins with no higher-order pregnancies being encountered. No fetal anomalies or malformations were reported in 25 children after a mean follow-up of 40.4 ± 26.4 months. Seventeen of the 33 women attempting pregnancy had at least one child, translating into an FP rate of 51.5% per attempting woman.
  
  
  CONCLUSIONS
  Embryo cryopreservation after ovarian stimulation with the letrozole and follicle-stimulating hormone protocol preserves fertility in women with breast cancer and results in pregnancy rates comparable to those expected in a noncancer population undergoing in vitro fertilization.
authors.affiliation: Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY. koktay@fertilitypreservation.org.
authors.forename: Kutluk
authors.initials: K
authors.lastname: Oktay
authors.affiliation: Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
authors.forename: Volkan
authors.initials: V
authors.lastname: Turan
authors.affiliation: Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Bedoschi
authors.affiliation: Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
authors.forename: Fernanda S
authors.initials: FS
authors.lastname: Pacheco
authors.affiliation: Kutluk Oktay, Volkan Turan, Giuliano Bedoschi, and Fernanda S. Pacheco, New York Medical College, Valhalla, and Innovation Institute for Fertility Preservation and In Vitro Fertilization, New York; and Fred Moy, New York Medical College, Valhalla, NY.
authors.forename: Fred
authors.initials: F
authors.lastname: Moy
mesh_terms: D000328:Adult; D047072:Aromatase Inhibitors / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015925:Cryopreservation; D004622:Embryo, Mammalian; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D000077289:Letrozole; D009367:Neoplasm Staging; D009570:Nitriles / Q000008:administration & dosage*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy / Q000706:statistics & numerical data; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D014481:United States / Q000453:epidemiology
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D005640:Follicle Stimulating Hormone