title: Biological and radiological exploration and management of non-functioning pituitary adenoma.
abstract: Non-functioning pituitary adenoma may be totally asymptomatic and discovered "incidentally" during radiological examination for some other indication, or else induce tumoral signs with compression of the optic chiasm and pituitary dysfunction. Non-functioning adenomas are mainly gonadotroph, but may also be "silent". Treatment strategy depends on initial clinical, biological, ophthalmological and radiological findings. The present French Society of Endocrinology Consensus work-group sought to update the pitfalls associated with hormone assay and outline a hormonal exploration strategy for diagnosis and follow-up, without overlooking the particularities of silent adenoma. We also drew up basic rules for initial exploration and radiological follow-up of both operated and non-operated pituitary adenomas.
authors.affiliation: Fédération d'endocrinologie, groupement hospitalier Est, hospices civils de Lyon, 69372 Lyon, France; Inserm U1028, CNRS UMR5292, Lyon neuroscience research center, neuro-oncology and neuro-inflammation team, université Lyon-1, 69372 Lyon, France. Electronic address: gerald.raverot@chu-lyon.fr.
authors.forename: Gérald
authors.initials: G
authors.lastname: Raverot
authors.affiliation: Center for rare adrenal diseases, department of endocrinology, hôpital Cochin, AP-HP, 75014 Paris, France; Inserm U1016, institut Cochin, 75014 Paris, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Assié
authors.affiliation: Service de radiologie, groupement hospitalier Sud, hospices civils de Lyon, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France; Inserm U630, CREATIS-LRMN, CNRS UMR 5220, université Lyon-1, 69621 Villeurbanne cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Cotton
authors.affiliation: Département d'endocrinologie, CHU, Saint-Pierre, Reunion.
authors.forename: Muriel
authors.initials: M
authors.lastname: Cogne
authors.affiliation: Département de neuroradiologie, hôpital Foch, 92151 Suresnes, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Boulin
authors.affiliation: Laboratoire de médecine nucléaire, centre de biologie-pathologie, CHRU de Lille, 59020 Lille, France; Faculté de médecine, université Lille 2, 59045 Lille, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Dherbomez
authors.affiliation: Université de Liège, CHU de Liège, domaine universitaire du Sart-Tilman, 4000 Liège, Belgium.
authors.forename: Jean François
authors.initials: JF
authors.lastname: Bonneville
authors.affiliation: Unité fonctionnelle d'hormonologie, pôle biologie, CHU de Pontchaillou, rue Henri-Le-Guilloux, 35043 Rennes, France; Inserm 1414, centre d'investigation clinique, université de Rennes 1, 35033 Rennes, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Massart
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D032921:Consensus; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D011859:Radiography
chemical_list: D006062:Gonadotropins; D010907:Pituitary Hormones
keywords: Adénome hypophysaire non fonctionnel; Adénome hypophysaire silencieux; Adénomes hypophysaire gonadotrope; Incidentalome hypophysaire; Insuffisance antehypophysaire; Non-functioning pituitary adenoma; Pituitary gonadotroph tumor; Pituitary incidentaloma; Pituitary insufficiency; Silent pituitary adenoma