title: The Surgical Management of Klatskin Tumours: Has Anything Changed in the Last Decade?
abstract: Surgical treatment of hilar cholangiocarcinomas requires complex pre-, intra- and post-operative decision-making. Despite the significant progress in liver surgery over the years, several issues such as the role of pre-operative biliary drainage, portal vein embolisation, staging laparoscopy and neo-adjuvant chemotherapy remain unresolved. Operative strategies such as vascular resection, caudate lobe resection and liver transplant have also been practiced in order to improve R0 resectability and improved survival. The review aims to consolidate evidence from major studies in the last 11 years. Survival data were only included from studies that reported the results in at least 30 patients with 1-year follow-up. A significant number of patients may be prevented an unnecessary laparotomy if they underwent a staging laparoscopy. There remain no guidelines as to when portal vein embolisation or pre-operative biliary drainage should be employed but most studies agree with pre-operative biliary drainage being an absolute indication if portal vein embolisation is performed. Concomitant hepatectomy and caudate lobectomy increases R0 resection but vascular resection cannot be routinely recommended. Liver transplant at specialised centres in selective patients has had impressive results. Guidelines are required for pre-operative biliary drainage and portal vein embolisation and randomised trials are required in order to define the role of vascular resection in achieving a R0 resection and increasing survival.
authors.affiliation: Department of Hepatobiliary Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK. neilbhardwaj@yahoo.co.uk.
authors.forename: Neil
authors.initials: N
authors.lastname: Bhardwaj
authors.affiliation: Department of Hepatobiliary Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Garcea
authors.affiliation: Department of Hepatobiliary Surgery, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK.
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Dennison
authors.affiliation: Discipline of Surgery, The Queen Elizabeth Hospital, University of Adelaide, Woodville, Adelaide, Australia.
authors.forename: Guy J
authors.initials: GJ
authors.lastname: Maddern
mesh_terms: D001650:Bile Duct Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic; D004322:Drainage; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D018285:Klatskin Tumor / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D010535:Laparoscopy; D016031:Liver Transplantation; D009367:Neoplasm Staging; D011169:Portal Vein / Q000601:surgery; D011300:Preoperative Care; D015996:Survival Rate