title: Laparoscopic TME associated with neoadjuvant chemoradiation towards aggressive colorectal cancer.
abstract: OBJECTIVE
  This study aims to investigate the clinical synchronization of the neoadjuvant chemoradiation (NC) and the laparoscopic total mesorectal excision (TME) in the treatment of locally aggressive colorectal cancer (LACC).
  
  
  METHODS
  92 LACC patients were selected for the research, among who 46 cases, who were performed the synchronized NC, were divided into the treatment group, after having rest for 4-6 weeks after the treatment, the 40 patients of the treatment group, who were performed the laparoscopic surgery, formed the laparoscopy group. The rest 46 patients were divided into the control group, who were performed the conventional treatment. The intraoperative conditions, postoperative recoveries, postoperative complications and recurrence rates of the two groups were compared.
  
  
  RESULTS
  The stage-declining rate of the treatment group was 67.3%, and the surgical resection rate, anal preservation rate and postoperative complications were 86.9%, 69.6% and 26%, respectively, which were significantly higher than the control group; while the long-term recurrence rate significantly decreased to 21.7%, and the difference was statistically significant (P<0.05).
  
  
  CONCLUSIONS
  The NC could effectively achieve the stage-declining purpose against the LACC, improve the resection rate and reduce the postoperative recurrence rate.
authors.affiliation: Department of Gastrointestinal Surgery, Hubei Provincial Cancer Hospital Wuhan 430060, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yin
authors.affiliation: Department of Gastrointestinal Surgery, Hubei Provincial Cancer Hospital Wuhan 430060, China.
authors.forename: Dian-Sheng
authors.initials: DS
authors.lastname: Cui
authors.affiliation: Department of Gastrointestinal Surgery, Hubei Provincial Cancer Hospital Wuhan 430060, China.
authors.forename: Zhi-Guo
authors.initials: ZG
authors.lastname: Xiong
authors.affiliation: Department of Gastrointestinal Surgery, Hubei Provincial Cancer Hospital Wuhan 430060, China.
authors.forename: Shao-Zhong
authors.initials: SZ
authors.lastname: Wei
keywords: Laparoscopy; aggressive colorectal cancer; neoadjuvant chemoradiation