title: A series of patients with minimal change nephropathy treated with rituximab during adolescence and adulthood.
abstract: BACKGROUND
  The treatment of immune suppression dependent minimal change nephropathy (MCN) can be challenging and frequently leads to serious complications. In paediatric patients, successful treatment with rituximab is described in steroid-dependent MCN. There is limited information about the potential efficacy of rituximab for the treatment of MCN in adults and adolescence. We describe our experience with rituximab in adolescent and adult patients with immune suppression dependent MCN.
  
  
  RESULTS
  Ten adolescents and adults with immune suppression dependent MCN and therapy related complications were treated with rituximab. At a mean age of 26 years, about 10.5 years after first presentation, they received two doses of rituximab (375 mg/m(2)). Maintenance immunosuppressive medication was stopped. After a mean follow-up of 43 months, three patients had four relapses. Three relapses were successfully retreated with rituximab again, after induction therapy with 60 mg prednisone per day. Rituximab was well tolerated and no infectious complications were recorded.
  
  
  CONCLUSIONS
  Treatment with rituximab induces a long-term remission of immune suppression dependent MCN in adolescents and adults. A timely treatment with rituximab could be considered to limit side effects of immunosuppressive medication.
authors.affiliation: Department of Nephrology, Erasmus MC, Room H 438, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. riendekkers@solcon.nl.
authors.forename: Marinus J
authors.initials: MJ
authors.lastname: Dekkers
authors.affiliation: Emma Children's Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. j.w.groothoff@amc.uva.nl.
authors.forename: Jaap W
authors.initials: JW
authors.lastname: Groothoff
authors.affiliation: Department of Nephrology, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. r.zietse@erasmusmc.nl.
authors.forename: Robert
authors.initials: R
authors.lastname: Zietse
authors.affiliation: Department of Nephrology, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. m.g.h.betjes@erasmusmc.nl.
authors.forename: Michiel G H
authors.initials: MG
authors.lastname: Betjes
mesh_terms: D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D060828:Induction Chemotherapy; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction; D012189:Retrospective Studies; D000069283:Rituximab / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D000069283:Rituximab; D011241:Prednisone