title: Value of human brain natriuretic peptide in treatment of acute anterior myocardial infarction evaluated via three-dimensional speckle tracking imaging.
abstract: Three-dimensional ultrasound speckle tracking imaging was used to evaluate the effects of recombinant human brain natriuretic peptide (rhBNP) in acute anterior and extensive anterior myocardial infarction. Ninety patients with acute anterior or extensive myocardial infarction were randomly divided into 3 groups: Group A [emergency percutaneous coronary intervention (PCI)], Group B (emergency PCI + rhBNP early treatment), and Group C (emergency PCI + late rhBNP treatment). Within 6 h of admission and at 1 week and 3 and 6 months after PCI, patients underwent routine transthoracic echocardiography and real-time three-dimensional echocardiography. At 1 week, 1 month, 3 months, 6 months, and 12 months, ejection fraction values in groups B and C were significantly greater than those in group A (P < 0.05), and left ventricular end-diastolic volume and left ventricular end-systolic volume values in groups B and C were less than those in group A (P < 0.05). Within 6 h of admission in each group, long-axis, radial, circumferential, and area variables corresponding to anterior descending artery segments showed no significant difference (all P > 0.05). However, at 1 week, 1 month, 3 months, 6 months, and 12 months, long-axis, radial, circumferential and area variables in groups B and C were significantly less than those in group A (P < 0.05). Intervention with rhBNP can im-prove resilience of the local myocardium, left ventricular mechanical function, and cardiac remodeling. Within 6 h of admission or after PCI, rhBNP application showed no significant difference in heart function improvement or myocardial remodeling inhibition.
authors.affiliation: The Third Clinical Medical College of Southern Medical University, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Third Clinical Medical College of Southern Medical University, Guangzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Gao
authors.affiliation: The Third Clinical Medical College of Southern Medical University, Guangzhou, China.
authors.forename: X-Y
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: The Third Clinical Medical College of Southern Medical University, Guangzhou, China houym126vip@126.com.
authors.forename: Y-M
authors.initials: YM
authors.lastname: Hou
authors.affiliation: Department of Cardiology, Affiliated Ningde Hospital of Fujian Medical University Ningde, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Cardiology, Affiliated Ningde Hospital of Fujian Medical University Ningde, China.
authors.forename: S-L
authors.initials: SL
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Affiliated Ningde Hospital of Fujian Medical University Ningde, China.
authors.forename: S-H
authors.initials: SH
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Affiliated Ningde Hospital of Fujian Medical University Ningde, China.
authors.forename: R-Y
authors.initials: RY
authors.lastname: Luo
authors.affiliation: Department of Cardiology, Affiliated Ningde Hospital of Fujian Medical University Ningde, China.
authors.forename: S-F
authors.initials: SF
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D056988:Anterior Wall Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000008:administration & dosage* / Q000235:genetics; D011859:Radiography; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000235:genetics; D016276:Ventricular Function / Q000187:drug effects* / Q000235:genetics
chemical_list: D011994:Recombinant Proteins; D020097:Natriuretic Peptide, Brain