title: Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.
abstract: Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.
authors.affiliation: Laboratory of Molecular Immunology and Parasitology, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. analegarda@usal.es.
authors.forename: Ana L
authors.initials: AL
authors.lastname: Legarda-Ceballos
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. olmo@usal.es.
authors.forename: Esther
authors.initials: E
authors.lastname: del Olmo
authors.affiliation: Laboratory of Molecular Immunology and Parasitology, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. jlaban@usal.es.
authors.forename: Julio
authors.initials: J
authors.lastname: López-Abán
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. ricar@usal.es.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Escarcena
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Sciences, Catholic University of the North, 0610-Antofagasta, Chile. luisbustosg@gmail.com.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Bustos
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, Complutense University of Madrid (CEI Campus Moncloa, UCM-UPM & CSIC), 28040-Madrid, Spain. crfonseca@pdi.ucm.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Fonseca-Berzal
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, Complutense University of Madrid (CEI Campus Moncloa, UCM-UPM & CSIC), 28040-Madrid, Spain. agbarrio@ucm.es.
authors.forename: Alicia
authors.initials: A
authors.lastname: Gómez-Barrio
authors.affiliation: Research Center on Health for the Tropics, (CIST), Carretera Troncal del Caribe, Sector Mamatoco, Santa Marta, Magdalena, Colombia. juandib@hotmail.com.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Dib
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. asf@usal.es.
authors.forename: Arturo
authors.initials: A
authors.lastname: San Feliciano
authors.affiliation: Laboratory of Molecular Immunology and Parasitology, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. ama@usal.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Muro
mesh_terms: D000438:Alcohols / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000469:parasitology; D002522:Chlorocebus aethiops; D003959:Diamines / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D014344:Trypanocidal Agents / Q000008:administration & dosage* / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000472:pathogenicity; D014709:Vero Cells
chemical_list: D000438:Alcohols; D003959:Diamines; D014344:Trypanocidal Agents
keywords: Trypanosoma cruzi; amastigotes; aminoalcohols; cytotoxicity; diamines; epimastigotes