title: The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum.
abstract: OBJECTIVE
  The aim of this research was to determine the prevalence and sonographic appearance of the hippocampal commissure in fetuses with isolated complete agenesis of the corpus callosum by three-dimensional neurosonography in the multiplanar mode.
  
  
  METHODS
  This was a multicenter observational study. Stored volume datasets of fetuses with isolated complete agenesis of the corpus were retrospectively retrieved for analysis in three tertiary centers. The presence or absence of the hippocampal commissure was independently evaluated in the coronal and midsagittal planes by two operators. Postnatal follow-up was obtained in all cases.
  
  
  RESULTS
  From November 2007 to February 2013, 41 cases between 19 and 30 weeks of gestation were retrieved for analysis. The hippocampal commissure was visible in the coronal and sagittal planes in 27/41 (65.8%), absent or not clearly recognizable in the remaining 14 cases. The qualitative analysis of the two operators was concordant in 100% of cases.
  
  
  CONCLUSIONS
  In more than half of fetuses with complete callosal agenesis, the hippocampal commissure may be visualized at prenatal ultrasound. This is a residual interhemispheric connection, which in normal cases is hidden by the corpus callosum itself. Further research is needed to establish if this has an impact on postnatal outcome.
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Contro
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.|Department of Obstetrics and Gynaecology, Carlo Poma Hospital, Mantova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Nanni
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bellussi
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Salsi
authors.affiliation: Department of Obstetrics and Gynaecology, Carlo Poma Hospital, Mantova, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grisolia
authors.affiliation: Maternal-Fetal Medicine Department, Hospital Clinic, University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sanz-Cortès
authors.affiliation: Department of Radiology and Neuroradiology, Children's hospital V. Buzzi, Italy.
authors.forename: A
authors.identifier: http://orcid.org/0000-0003-3396-7413
authors.initials: A
authors.lastname: Righini
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Rizzo
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pilu
authors.affiliation: Fetal Medicine Unit, S. Orsola-Malpighi Hospital, University of Bologna, Italy.|Department of Obstetrics, Maggiore Hospital, University of Parma, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Ghi
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum / Q000000981:diagnostic imaging* / Q000196:embryology; D005260:Female; D005500:Follow-Up Studies; D020712:Fornix, Brain / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D006801:Humans; D021621:Imaging, Three-Dimensional; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods