title: MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia.
abstract: Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n=841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p=0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder.
authors.affiliation: The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA. Electronic address: vpatel@mrn.org.
authors.forename: Veena S
authors.initials: VS
authors.lastname: Patel
authors.affiliation: Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland. Electronic address: kellys37@tcd.ie.
authors.forename: Sinead
authors.initials: S
authors.lastname: Kelly
authors.affiliation: The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA. Electronic address: clwright@salud.unm.edu.
authors.forename: Carrie
authors.initials: C
authors.lastname: Wright
authors.affiliation: The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA. Electronic address: ncota@mrn.org.
authors.forename: Cota Navin
authors.initials: CN
authors.lastname: Gupta
authors.affiliation: Technische Universität Dresden, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Translational Developmental Neuroscience Section, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: alejandro.ariasvasquez@radboudumc.nl.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Arias-Vasquez
authors.affiliation: Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA. Electronic address: nbizzozero@salud.unm.edu.
authors.forename: Nora
authors.initials: N
authors.lastname: Perrone-Bizzozero
authors.affiliation: Technische Universität Dresden, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Translational Developmental Neuroscience Section, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: stefan.erhlich@uniklinikum-dresden.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ehrlich
authors.affiliation: Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA. Electronic address: leiwang1@northwestern.edu.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA. Electronic address: jbustillo@salud.unm.edu.
authors.forename: Juan R
authors.initials: JR
authors.lastname: Bustillo
authors.affiliation: Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland; Clinical Neuroimaging Laboratory and Cognitive Genetics group, Departments of Psychiatry, Anatomy, Biochemistry and School of Psychology, National University of Ireland, Galway, Ireland. Electronic address: derek.morris@nuigalway.ie.
authors.forename: Derek
authors.initials: D
authors.lastname: Morris
authors.affiliation: Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland. Electronic address: acorvin@tcd.ie.
authors.forename: Aiden
authors.initials: A
authors.lastname: Corvin
authors.affiliation: Clinical Neuroimaging Laboratory and Cognitive Genetics group, Departments of Psychiatry, Anatomy, Biochemistry and School of Psychology, National University of Ireland, Galway, Ireland. Electronic address: dara.cannon@nuigalway.ie.
authors.forename: Dara M
authors.initials: DM
authors.lastname: Cannon
authors.affiliation: Clinical Neuroimaging Laboratory and Cognitive Genetics group, Departments of Psychiatry, Anatomy, Biochemistry and School of Psychology, National University of Ireland, Galway, Ireland. Electronic address: colm.mcdonald@nuigalway.ie.
authors.forename: Colm
authors.initials: C
authors.lastname: McDonald
authors.affiliation: Neuropsychiatric Genetics Research Group, Department of Psychiatry, and Trinity College Institute for Neuroscience, Trinity College Dublin, Ireland; Clinical Neuroimaging Laboratory and Cognitive Genetics group, Departments of Psychiatry, Anatomy, Biochemistry and School of Psychology, National University of Ireland, Galway, Ireland. Electronic address: gary.donohoe@nuigalway.ie.
authors.forename: Gary
authors.initials: G
authors.lastname: Donohoe
authors.affiliation: The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA; Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA; Departments of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: vcalhoun@mrn.org.
authors.forename: Vince D
authors.initials: VD
authors.lastname: Calhoun
authors.affiliation: The Mind Research Network and Lovelace Respiratory Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA; Departments of Psychology and Neurosciences, Georgia State University, Atlanta, GA 30302, USA. Electronic address: jturner@mrn.org.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Turner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044465:White People; D055815:Young Adult
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs
keywords: Corpus callosum; MIR137; Multi-site; Schizophrenia; Subcortical volume; microRNA-137