title: Effect of Prophylactic Palivizumab on Admission Due to Respiratory Syncytial Virus Infection in Former Very Low Birth Weight Infants with Bronchopulmonary Dysplasia.
abstract: The aim of this study was to observe the effects of prophylactic palivizumab on hospitalization secondary to respiratory syncytial virus (RSV) infection (RSVhospitalization) in former very low birth weight infants (VLBWI) with bronchopulmonary dysplasia (BPD). This study also sought to identify the risk factors of RSVhospitalizationin this particular infant population. A prospective observational study was conducted between September 2007 and April 2008 in seven Korean hospitals. Children with a history of very low birth weight, a diagnosis of BPD and who were <2 yr old at the onset of the RSV season were included in this study. Palivizumab injections were administered monthly for a maximum of five months during the RSV season. RSVhospitalization rates were reviewed, and RSVhospitalization rates between subgroups were categorized by gestational age, birth weight, and duration of ventilator care. A total of 90 subjects completed the follow-up interviews. The mean gestational age at birth was 26.1±1.7 weeks, and the mean birth weight was 889.4±222.2 g. The incidence of RSVhospitalization in the study population was 8.9% (8/90), and the mean hospital stay was 11.0±5.5 days, including one death. There were no statistically significant differences in the patients' demographic characteristics or risk factors for RSV hospitalization. When subgroup analyses were conducted, there were still no statistically significant differences. The administration of palivizumab prophylaxis during the entire RSV season is important in VLBWI with BPD, regardless of their gestational age and birth weight, or previous ventilator dependency.
authors.affiliation: Department of Pediatrics, Pusan National University School of Medicine, Children's Hospital, Yangsan, Korea.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Han
authors.affiliation: Department of Pediatrics, Seoul Medical Center, Seoul, Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Seo
authors.affiliation: Department of Pediatrics, Changwon Samsung Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
authors.forename: Seo Heui
authors.initials: SH
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, Inje University Haeundae Paik Hospital, Pusan, Korea.
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Jung
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: So Yoon
authors.initials: SY
authors.lastname: Ahn
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hye Soo
authors.initials: HS
authors.lastname: Yoo
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Se In
authors.initials: SI
authors.lastname: Sung
authors.affiliation: Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Shim
authors.affiliation: Department of Pediatrics, Cheil General Hospital and Women's Healthcare Center, Dankook University, College of medicine, Seoul, Korea.
authors.forename: Yeon Kyung
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, Cheil General Hospital and Women's Healthcare Center, Dankook University, College of medicine, Seoul, Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Ko
authors.affiliation: Department of Pediatrics, Cheil General Hospital and Women's Healthcare Center, Dankook University, College of medicine, Seoul, Korea.
authors.forename: Son Moon
authors.initials: SM
authors.lastname: Shin
authors.affiliation: Department of Pediatrics, Ilsan Paik Hospital, Inje University School of Medicine, Goyang, Korea.
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jang Hoon
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Byung Min
authors.initials: BM
authors.lastname: Choi
authors.affiliation: Department of Pediatrics, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon, Korea.
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Kim
authors.affiliation: CHA Gangnam Medical Center, CHA University, Seoul.
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Jeon
authors.affiliation: Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Sung Shin
authors.initials: SS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yun Sil
authors.initials: YS
authors.lastname: Chang
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Won Soon
authors.initials: WS
authors.lastname: Park
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000150:complications*; D005260:Female; D005865:Gestational Age; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007902:Length of Stay; D008297:Male; D000069455:Palivizumab / Q000627:therapeutic use*; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D012306:Risk; D012307:Risk Factors
chemical_list: D000998:Antiviral Agents; D000069455:Palivizumab
keywords: Bronchopulmonary Dysplasia; Hospitalization; Infant; Palivizumab; Preterm; Respiratory Syncytial Viruses