title: BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients.
abstract: We propose an extensive review of the literature about BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients. Five genome-wide association studies and 30 association studies were included. Twenty seven studies focused on the Val66Met polymorphism (rs6265), the Met allele being associated with a higher antidepressant efficacy only in Asian patients. Other BDNF/TRKB/P75NTR polymorphisms (BDNF: rs7103411, rs7124442, rs908867, rs2049046, rs61888800, rs10501087, rs1491850; TRKB: rs10868223, rs11140778, rs1565445, rs1659412; P75NTR: rs2072446) were reported to be associated with antidepressant efficacy but these results were not replicated. Finally, there are 15 positive studies among 30 studies regarding BDNF/TRKB/P75NTR polymorphisms. The only SNP which benefits of at least three positive studies is the BDNF Val66Met polymorphism (rs6265). Consequently, with a lack of good and consistent studies, the clinical utility of BDNF in treatment selection is far from clear. We propose several recommendations for further studies.
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Colle
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Deflesselle
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Martin
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Pharmacie Paris Sud, Châtenay-Malabry, France.
authors.forename: Denis J
authors.initials: DJ
authors.lastname: David
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Hardy
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Adéla
authors.initials: A
authors.lastname: Taranu
authors.affiliation: INSERM UMR 1178, Faculté de Médecine Paris Sud, Département de Biostatistiques, Hôpital Paul Brousse, Assistance Publique Hôpitaux de Paris, 94400 Villejuif, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Falissard
authors.affiliation: INSERM U1184 'Immunologie des maladies virales et auto-immunes' University Paris Sud, Service de Génétique moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre F-94275, France.|University Paris-Sud, INSERM U1184, 92296 Chatenay-Malabry Cedex, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.affiliation: INSERM UMR 1178 Team 'Depression & Antidepressants', Faculté de Médecine Paris Sud, Service de Psychiatrie, Hôpital Bicêtre, Assistance Publique Hôpitaux de Paris, 94275 Le Kremlin Bicêtre, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Corruble
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020813:Receptor, trkB; D017475:Receptors, Nerve Growth Factor / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D008562:Membrane Glycoproteins; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; C579455:BDNF protein, human; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; C000591259:tropomyosin-related kinase-B, human
keywords: BDNF; PNTR75; TRKB; antidepressant remission; antidepressant response; major depressive disorder; major depressive episode; single nucleotide polymorphism