title: [Chromosomal aberrations--the cause of spontaneous abortions].
abstract: The genetic factor remains the most frequent cause of spontaneous abortions. Examination of the fetal tissue from spontaneous miscarriages shows that 75% of them were caused by abnormal karyotype. Other reasons, albeit rare, included submicroscopic genomic rearrangements, monogenic diseases, and polygenic inheritance disorders of the embryo.
  
  
  OBJECTIVE
  The aim of the study was to analyze the incidence of chromosomal aberrations in material from the miscarriage.
  
  
  METHODS
  The study included 47 samples of miscarriage material from 47 women. Fluorescent hybridization in-situ (FISH) was used for genetic examination.
  
  
  RESULTS
  Chromosomal abnormalities were diagnosed in 72% of the samples, with trisomy 21 (25.5%), trisomy 16 (17%), and trisomy 18 (12.8%) as the most common. An abnormal number of copies of chromosome 18, 21, 22, indicating the coexistence of trisomy 18, 21, 22, was detected in 1 patient. It was another miscarriage in case of 14 subjects (29.8%).
  
  
  CONCLUSIONS
  Chromosomal aberrations were diagnosed in the majority of fetal tissue samples from spontaneous miscarriages. More than one chromosomal aberration in a single embryo is an extremely rare occurrence. Miscarriage due to chromosomal aberrations occurred in the vast majority of women > 35 years of age.
authors.forename: Dorota
authors.initials: D
authors.lastname: Rabiega-Gmyrek
authors.forename: Tomasz
authors.initials: T
authors.lastname: Olejniczak
authors.forename: Joanna
authors.initials: J
authors.lastname: Niepsuj-Biniaś
authors.forename: Bogna
authors.initials: B
authors.lastname: Guglas-Bochyńska
authors.forename: Paweł
authors.initials: P
authors.lastname: Jachowski
authors.forename: Anna
authors.initials: A
authors.lastname: Latos-Bieleńska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Opala
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D002901:Chromosomes, Human, 13-15 / Q000235:genetics*; D002902:Chromosomes, Human, 16-18 / Q000235:genetics*; D002904:Chromosomes, Human, 21-22 and Y / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008423:Maternal Age; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D014314:Trisomy / Q000235:genetics