title: Magnetically Targeted Stem Cell Delivery for Regenerative Medicine.
abstract: Stem cells play a special role in the body as agents of self-renewal and auto-reparation for tissues and organs. Stem cell therapies represent a promising alternative strategy to regenerate damaged tissue when natural repairing and conventional pharmacological intervention fail to do so. A fundamental impediment for the evolution of stem cell therapies has been the difficulty of effectively targeting administered stem cells to the disease foci. Biocompatible magnetically responsive nanoparticles are being utilized for the targeted delivery of stem cells in order to enhance their retention in the desired treatment site. This noninvasive treatment-localization strategy has shown promising results and has the potential to mitigate the problem of poor long-term stem cell engraftment in a number of organ systems post-delivery. In addition, these same nanoparticles can be used to track and monitor the cells in vivo, using magnetic resonance imaging. In the present review we underline the principles of magnetic targeting for stem cell delivery, with a look at the logic behind magnetic nanoparticle systems, their manufacturing and design variants, and their applications in various pathological models.
authors.affiliation: Joint Department of Biomedical Engineering, UNC-Chapel Hill & NC State University, NC 27606, USA. CoresJR@gmail.com.|Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. CoresJR@gmail.com.
authors.forename: Jhon
authors.initials: J
authors.lastname: Cores
authors.affiliation: Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. thomas_caranasos@med.unc.edu.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Caranasos
authors.affiliation: Joint Department of Biomedical Engineering, UNC-Chapel Hill & NC State University, NC 27606, USA. ke_cheng@ncsu.edu.|Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. ke_cheng@ncsu.edu.
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
keywords: SPION; magnetic nanoparticle; magnetic targeting; regenerative medicine; stem cell