title: Chitin dipentanoate as the new technologically usable biomaterial.
abstract: In this article, the synthesis of novel biopolymer, chitin dipentanoate (Di-O-Valeryl Chitin, DVCH) has been described. DVCH is a chitin derivative esterified with two valeryl groups at positions 3 and 6 of the N-acetylglucosamine units and it is soluble in common organic solvents like ethanol, methanol, acetone, dichloromethane, 1,2-dichloroethane, N,N-dimethylmethanamide, N,N-dimethylacetamide and ethyl acetate. Highly efficient synthesis (degree of esterification close to 2) of DVCH was achieved by employing a huge excess of valeric anhydride used as both the acylation agent and the reaction medium in the presence of perchloric acid as catalyst. Studies on the DVCH synthesis were aimed at finding optimal conditions (temperature, reaction time) to obtain DVCH with high reaction yield and desirable physicochemical properties. Biological data demonstrate that DVCH is non-cytotoxic in vitro and doesn't exert irritating or allergic effects to animal skin. Thanks to its filmogenic properties, it can be used to manufacture threads, foils, foams and non-woven materials. Moreover, DVCH can be easily processed by salt-leaching method to prepare highly porous structures exhibiting open-cell architecture, that can be further employed in wound dressing therapies and scaffolds for tissue engineering.
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland. Electronic address: karolina.skolucka@celther.com.
authors.forename: Karolina
authors.initials: K
authors.lastname: Skołucka-Szary
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Ramięga
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland.
authors.forename: Wanda
authors.initials: W
authors.lastname: Piaskowska
authors.affiliation: Silesian University of Technology, Faculty of Chemistry, Department of Physical Chemistry and Technology of Polymers, ul. M. Strzody 9, 44-100 Gliwice, Poland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Janicki
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Grala
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Rieske
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Stoczyńska-Fidelus
authors.affiliation: Department of Research and Development, Celther Poland Sp. z o.o., ul. Ostrzykowizna 14A, 05-170 Zakroczym, Poland.
authors.forename: Sylwester
authors.initials: S
authors.lastname: Piaskowski
mesh_terms: D000818:Animals; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry*; D002686:Chitin / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D016062:Porosity; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D012997:Solvents / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014631:Valerates / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D012997:Solvents; D014631:Valerates; D002686:Chitin
keywords: Biomaterial; Chitin; Esterification; Scaffolds