title: Cerebral Small-Vessel Disease in Neuro-Behçet Disease.
abstract: BACKGROUND
  Involvement of central nervous system is very common in Behçet disease, known as neuro-Behçet disease (NBD). However, there have been few reports which evaluated stroke-like cerebral small-vessel disease associated with Behçet disease.
  
  
  OBJECTIVE
  We evaluated cerebral small-vessel lesions by using magnetic resonance imaging in 2 patients with NBD.
  
  
  METHODS
  In a 41-year-old woman case, who developed dysarthria and left hemiparesis, diffusion-weighted images (DWI) showed small high-intensity areas in the bilateral internal capsule. The right lesion had a low apparent diffusion coefficient (ADC) value, whereas the left one had a high value. In a 59-year-old woman case, who developed dysarthria and left hemihypesthesia, DWI showed high-intensity areas in the right side of the pons and in the right peduncle of the midbrain. The lesion in the pons had a low ADC value, whereas the lesion in the midbrain had a high value. ADC map may be useful to identify symptomatic lesions in the brain, because only the lesions with low ADC values were symptomatic.
  
  
  CONCLUSIONS
  NBD should be considered in those who had not had any risk factors for ischemic stroke but experienced cerebral small-vessel disease.
authors.affiliation: Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address: sohei-y@ncvc.go.jp.
authors.forename: Sohei
authors.initials: S
authors.lastname: Yoshimura
authors.affiliation: Department of Nephrology, Hypertension, and Strokology, Kyushu University Hospital, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ago
authors.affiliation: Division of Cerebrovascular Medicine and Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Koga
authors.affiliation: Department of Nephrology, Hypertension, and Strokology, Kyushu University Hospital, Fukuoka, Japan; Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kamouchi
authors.affiliation: Department of Nephrology, Hypertension, and Strokology, Kyushu University Hospital, Fukuoka, Japan; Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Takanari
authors.initials: T
authors.lastname: Kitazono
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications*; D001921:Brain / Q000473:pathology; D059345:Cerebral Small Vessel Diseases / Q000175:diagnosis / Q000209:etiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged
keywords: Neuro-Behçet disease; apparent diffusion coefficient; diffusion-weighted image; lacunar infarction