title: Association of Disease Activity with Serum and Tear IL-2 Levels in Behçet Disease.
abstract: OBJECTIVE
  To investigate the association of Behçet disease activity with serum and tear interleukin-2 levels.
  
  
  METHODS
  The study was designed as a prospective case control study. The study population consisted of 45 patients with Behçet disease and 24 age and sex-matched healthy participants. Behçet disease patients were classified as active (24 patients) or inactive (21 patients) according to disease activity. Serum and tear interleukin-2 levels were determined using the enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  The mean serum and tear interleukin-2 levels of the active disease, inactive disease, and control groups were 17.04 ± 5.02 and 32.61 ± 16.53 pg/mL; 15.20 ± 4.68 and 29.61 ± 8.30 pg/mL; and 14.22 ± 4.18 and 28.89 ± 8.73 pg/mL, respectively. There was no statistically significant difference between the groups with respect to all measured data.
  
  
  CONCLUSIONS
  There was no significant difference in serum or tear IL-2 levels between Behçet patients and controls; there was no association of disease activity with serum and tear IL-2 levels.
authors.affiliation: a Fırat University School of Medicine, Department of Ophthalmology , Elazığ , Turkey .
authors.forename: Peykan
authors.initials: P
authors.lastname: Türkçüoğlu
authors.affiliation: b Baskent University, Department of Ophthalmology, Ankara, Turkey; and University of Wisconsin, Department of Ophthalmology and Visual Sciences , Madison , Wisconsin , USA .
authors.forename: Yonca Ozkan
authors.initials: YO
authors.lastname: Arat
authors.affiliation: a Fırat University School of Medicine, Department of Ophthalmology , Elazığ , Turkey .
authors.forename: Emrah
authors.initials: E
authors.lastname: Kan
authors.affiliation: c Fırat University School of Medicine, Department of Internal Medicine, Division of Rheumatology , Elazığ , Turkey .
authors.forename: Elif Kılıç
authors.initials: EK
authors.lastname: Kan
authors.affiliation: d Houston Oculoplastics Associates, Memorial Hermann Medical Plaza, Texas Medical Center , Houston , Texas , USA .
authors.forename: Imtiaz A
authors.initials: IA
authors.lastname: Chaudhry
authors.affiliation: e Fırat University School of Medicine, Department of Internal Medicine, Division of Rheumatology , Elazığ , Turkey , and.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Koca
authors.affiliation: a Fırat University School of Medicine, Department of Ophthalmology , Elazığ , Turkey .
authors.forename: Ülkü
authors.initials: Ü
authors.lastname: Çeliker
authors.affiliation: f Fırat University School of Medicine, Department of Biochemistry , Elazığ , Turkey.
authors.forename: Nevin
authors.initials: N
authors.lastname: İlhan
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013666:Tears / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005136:Eye Proteins; C508594:IL2 protein, human; D007376:Interleukin-2; C042434:tear proteins
keywords: Behçet; Behçet's disease; interleukin; interleukin-2; tear interleukin