title: Consumption of Argan Oil Improves Anti-Oxidant and Lipid Status in Hemodialysis Patients.
abstract: OBJECTIVE
  Virgin Argan oil (VAO) is of interest in oxidative stress and lipid profile because of its fat composition and antioxidant compounds. We investigated the effect of VAO consumption on lipid profile and antioxidant status in hemodialysis patients after a 4-week period of consumption.
  
  
  METHODS
  In a crossover, controlled trial, 37 patients (18 men, 19 women) with end-stage renal disease on maintenance hemodialysis, were randomly assigned to a 4-week VAO diet. Fasting plasma lipids, vitamin E and oxidized LDL (ox-LDL) were analyzed. Malondialdehyde (MDA) was determined before and after hemodialysis session.
  
  
  RESULTS
  There was no significant change in serum total cholesterol and ox-LDL. However, VAO consumption decreased the levels of triglyceride (p = 0.03), total cholesterol (p = 0.02) and low-density lipoprotein (p = 0.03) and increased the levels of high-density lipoprotein (p = 0.01). Plasma vitamin E contents significantly increased from baseline only in VAO-group (p < 0.001). Hemodialysis session increased MDA levels, but the increase in VAO group was less than in control group.
  
  
  CONCLUSIONS
  VAO consumption improved lipid profile and oxidative stress status in hemodialysis patients.
authors.affiliation: Pharmacology and Toxicology Department, Faculty of Medicine and Pharmacy, University Mohammed V, 10000, Rabat, Morocco.
authors.forename: Rachid
authors.initials: R
authors.lastname: Eljaoudi
authors.affiliation: Nephrology Department, Military Hospital Mohammed V, 10000, Rabat, Morocco.
authors.forename: Driss
authors.initials: D
authors.lastname: Elkabbaj
authors.affiliation: Nephrology Department, Military Hospital Mohammed V, 10000, Rabat, Morocco.
authors.forename: Abdelali
authors.initials: A
authors.lastname: Bahadi
authors.affiliation: Medical Biotechnologie lab (MedBiotech), Faculty of Medicine and Pharmacy, University Mohammed V, 10000, Rabat, Morocco.
authors.forename: Azeddine
authors.initials: A
authors.lastname: Ibrahimi
authors.affiliation: Nephrology Department, Military Hospital Mohammed V, 10000, Rabat, Morocco.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Benyahia
authors.affiliation: Pharmacology Department, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah, 30000, Fes, Morocco.
authors.forename: Mourad
authors.initials: M
authors.lastname: Errasfa
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016877:Oxidants; D018384:Oxidative Stress / Q000187:drug effects; D010938:Plant Oils / Q000008:administration & dosage*; D006435:Renal Dialysis; D029632:Sapotaceae; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D016877:Oxidants; D010938:Plant Oils; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D014810:Vitamin E; C555574:argan oil; D008315:Malondialdehyde; D002784:Cholesterol
keywords: Argan oil; chronic renal failure; lipid profile; oxidative stress