title: Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates.
abstract: Although leishmaniasis has been studied for over a century, the fight against cutaneous, mucocutaneous and visceral forms of the disease remains a hot topic. This review refers to the parasitic cell wall and more particularly to the constitutive glycoconjugates. The structures of the main glycolipids and glycoproteins, which are species-dependent, are described. The focus is on the disturbance of the lipid membrane by existing drugs and possible new ones, in order to develop future therapeutic agents.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France. vincent.ferrieres@ensc-rennes.fr.
authors.forename: Yari
authors.initials: Y
authors.lastname: Cabezas
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Florence
authors.initials: F
authors.lastname: Robert-Gangneux
authors.forename: Franck
authors.initials: F
authors.lastname: Daligault
authors.forename: Sorya
authors.initials: S
authors.lastname: Belaz
authors.forename: Caroline
authors.initials: C
authors.lastname: Nugier-Chauvin
authors.forename: Sylvain
authors.initials: S
authors.lastname: Tranchimand
authors.forename: Charles
authors.initials: C
authors.lastname: Tellier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gangneux
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000977:Antiparasitic Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism*; D006001:Glycoconjugates / Q000378:metabolism*; D007891:Leishmania / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D058990:Molecular Targeted Therapy
chemical_list: D000977:Antiparasitic Agents; D006001:Glycoconjugates