title: Size- and shape-dependent peroxidase-like catalytic activity of MnFe2O4 Nanoparticles and their applications in highly efficient colorimetric detection of target cancer cells.
abstract: The catalytic activity of nanocrystal catalysts depends strongly on their chemical composition, size, and shape. Herein, we report four different sizes and shapes of MnFe2O4 nanoparticles (NPs) prepared by a hydrothermal procedure. In addition, the size- and shape-dependent peroxidase-like activity of these NPs was first explored using 3,3',5,5'-tetramethyl-benzidine and H2O2 as peroxidase substrates. The results showed that the peroxidase-like activities of the MnFe2O4 NPs were size- and shape-dependent and followed the order of 4 nm (spherical) > 18 nm (plate-like) > 27 nm (near-cubic) > 16 nm (spherical); this order was closely related to their surface-to-volume ratio and atom arrangements. Such an investigation is of great significance for peroxidase nanomimetics with enhanced activity and utilization. Furthermore, folic acid (FA)-conjugated MnFe2O4 NPs allow the detection of folate receptor-rich cancer cells. Such investigation can be widely utilized for the identification of important target molecules.
authors.affiliation: Department of gynaecology and obstetrics, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, PR China.
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Peng
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Wang
authors.forename: Weisheng
authors.initials: W
authors.lastname: Liu
authors.forename: Haoli
authors.initials: H
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Zuo
authors.forename: Huiang
authors.initials: H
authors.lastname: Tang
authors.forename: Fengjuan
authors.initials: F
authors.lastname: Chen
authors.forename: Baodui
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D001560:Benzidines / Q000737:chemistry; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D005290:Ferric Compounds / Q000737:chemistry / Q000494:pharmacology; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005492:Folic Acid / Q000737:chemistry; D058972:Folic Acid Transporters / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D017895:Manganese Compounds / Q000737:chemistry / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000378:metabolism; D009195:Peroxidase
chemical_list: D001560:Benzidines; D005290:Ferric Compounds; D058972:Folic Acid Transporters; D017895:Manganese Compounds; C551151:manganese ferrite; C021758:3,3',5,5'-tetramethylbenzidine; D005492:Folic Acid; D006861:Hydrogen Peroxide; D009195:Peroxidase; D016650:Fluorescein-5-isothiocyanate