title: Mesalazine-induced Pleuropericarditis in a Patient with Crohn's Disease.
abstract: A 16-year-old boy was diagnosed with Crohn's disease. Treatment with oral mesalazine was started at 3 g per day; however, he complained of high fever, a nonproductive cough, and left shoulder pain after 2 weeks. His chest radiography and chest computed tomography showed cardiomegaly and left pleural effusion, while an echocardiogram revealed pericardial effusion. Because no infection was detected by thoracentesis and the drug lymphocyte stimulation tests for mesalazine were positive, the patient was diagnosed with mesalazine-induced pleuropericarditis. After the cessation of mesalazine, the clinical symptoms and laboratory findings quickly improved.
authors.affiliation: Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan.
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Kiyomatsu
authors.forename: Kazushige
authors.initials: K
authors.lastname: Kawai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Jyunichiro
authors.initials: J
authors.lastname: Tanaka
authors.forename: Tomomichi
authors.initials: T
authors.lastname: Kiyomatsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nozawa
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kazama
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ishihara
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Sunami
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D003371:Cough / Q000209:etiology; D003424:Crohn Disease / Q000188:drug therapy*; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000008:administration & dosage / Q000009:adverse effects*; D010493:Pericarditis / Q000139:chemically induced* / Q000209:etiology; D010996:Pleural Effusion / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine