title: [A STUDY OF OCCURRENCE FREQUENCY OF C677T POLYMORPHISM OF THE GENE MTHFR AND PLASMA FOLATE LEVELS IN PATIENTS WITH UNIPOLAR DEPRESSION].
abstract: This study focuses on the problem of finding an effective diagnostic algorithm to identify unipolar depression by examining the C677T MTHFR gene polymorphism and features of folate metabolism in patients with unipolar depression. The study proves that C677T MTHFR gene polymorphism is significantly associated with unipolar depression, which can be used to improve the quality of depression identification, as well as forming new ways of diagnosis.
authors.forename: V L
authors.initials: VL
authors.lastname: Velichko
authors.forename: O I
authors.initials: OI
authors.lastname: Kudlach
authors.forename: O A
authors.initials: OA
authors.lastname: Shelepina
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005492:Folic Acid / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D015870:Gene Expression; D006720:Homozygote; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D059645:Mutation Rate; D020641:Polymorphism, Single Nucleotide; D011581:Psychological Tests
chemical_list: D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)