title: Prediction of gestational diabetes mellitus by first trimester serum secreted frizzle-related protein-5 levels.
abstract: OBJECTIVE
  The main aim of this study was to investigate the first trimester maternal serum secreted frizzle-related protein-5 (Sfrp-5) levels and to evaluate the predictive value on the subsequently developed gestational diabetes mellitus (GDM).
  
  
  METHODS
  A total of 40 pregnant women who subsequently developed GDM and 44 age- and pre-pregnancy BMI-matched healthy pregnant women were enrolled in this prospective case-control study. First trimester serum Sfrp-5 levels were evaluated to determine if there is an association with the onset of GDM, by using logistic regression analysis.
  
  
  RESULTS
  Decreased first trimester serum Sfrp-5 levels (OR = 14.332, 95%CI: 4.166-49.301, p < 0.001) were found to be significantly associated with the increased risk of GDM. There were no statistically significant differences in serum Sfrp-5 levels between the diet- and insulin-treated GDM groups and also serum Sfrp-5 levels were not found to be predictive for adverse perinatal outcomes (p > 0.05).
  
  
  CONCLUSIONS
  Decreased first trimester serum Sfrp-5 levels are significantly associated with the increased risk of GDM.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Efser
authors.initials: E
authors.lastname: Oztas
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ozler
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Ebru
authors.initials: E
authors.lastname: Ersoy
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Ali Ozgur
authors.initials: AO
authors.lastname: Ersoy
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.affiliation: b Department of Clinical Biochemistry , Yildirim Beyazit University Faculty of Medicine , Ankara , Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D016021:Epidemiologic Studies; D005136:Eye Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First / Q000097:blood; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D005136:Eye Proteins; D008565:Membrane Proteins; C118511:SFRP5 protein, human; D000094742:Secreted Frizzled-Related Proteins
keywords: Adverse perinatal outcomes; gestational diabetes mellitus; secreted frizzle-related protein-5