title: [Bone and Nutrition. Sclerostin and bone metabolism].
abstract: Osteocytes orchestrate bone resorption and bone formation by controlling osteoclast and osteoblast activity. On the other hand, osteocytes secret FGF23 (fibroblast growth factor 23), FGF23 acts on the kidney to control phosphate homeostasis. Sclerostin is also released from osteocytes and it regulated osteoblast activity through Wnt/β-catenin pathway. Therefore, an antibody that targets sclerostin is currently in phase- III clinical trials for the treatment of osteoporosis and it is expected as new therapeutics.
authors.affiliation: Department of Molecular Nutrition, Institute of Health Bioscience, University of Tokushima Graduate School, Japan.
authors.forename: Sawako
authors.initials: S
authors.lastname: Tatsumi
authors.forename: Kenta
authors.initials: K
authors.lastname: Nagamoto
authors.forename: Mao
authors.initials: M
authors.lastname: Ogata
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D019485:Bone Morphogenetic Proteins / Q000276:immunology* / Q000378:metabolism / Q000502:physiology*; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D017326:Clinical Trials, Phase III as Topic; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005819:Genetic Markers / Q000276:immunology* / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051379:Mice; D058990:Molecular Targeted Therapy; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010011:Osteocytes / Q000378:metabolism / Q000502:physiology*; D010012:Osteogenesis / Q000235:genetics; D010024:Osteoporosis / Q000188:drug therapy; D010710:Phosphates / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000911:Antibodies, Monoclonal; D019485:Bone Morphogenetic Proteins; C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; D005819:Genetic Markers; D010710:Phosphates; C422903:SOST protein, human; D051176:beta Catenin; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium