title: Poor judgment of distance between nociceptive stimuli.
abstract: Although pain is traditionally assumed to be poorly localized, recent work indicates that spatial acuity for nociception is surprisingly high. Here we investigated whether the nervous system can also accurately estimate the distance between two nociceptive stimuli. Estimating distance implies a metric representation of spatial relations, a property that underlies abilities such as perceiving the size of external objects. We presented pairs of simultaneous nociceptive or non-nociceptive somatosensory stimuli, and asked participants to judge the distance between them. Judgments of distance between nociceptive stimuli were much worse than judgments of distance between non-nociceptive tactile stimuli, even on skin regions where spatial acuity for nociception exceeded spatial acuity for touch. Control experiments ruled out explanations based on inaccurate localization of double nociceptive stimuli. Thus, the nervous system poorly represents the distance between two nociceptive stimuli. The dissociation between high spatial acuity and poor distance judgment in the nociceptive system may reflect a specialization for computing accurate spatial representations useful to protect the body, rather than to perceive the size of external objects.
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom; Institute of Cognitive Neuroscience, University College London, United Kingdom. Electronic address: f.mancini@ucl.ac.uk.
authors.forename: Flavia
authors.initials: F
authors.lastname: Mancini
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom.
authors.forename: Hannah
authors.initials: H
authors.lastname: Steinitz
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom.
authors.forename: James
authors.initials: J
authors.lastname: Steckelmacher
authors.affiliation: Department of Neuroscience, Physiology and Pharmacology, University College London, United Kingdom.
authors.forename: Gian Domenico
authors.initials: GD
authors.lastname: Iannetti
authors.affiliation: Institute of Cognitive Neuroscience, University College London, United Kingdom.
authors.forename: Patrick
authors.initials: P
authors.lastname: Haggard
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008297:Male; D010146:Pain / Q000523:psychology*; D010812:Physical Stimulation; D013028:Space Perception / Q000502:physiology*; D014110:Touch / Q000502:physiology; D055698:Touch Perception / Q000502:physiology*; D055815:Young Adult
keywords: Nociception; Pain; Parietal cortex; Somatosensory system; Space; Spatial remapping; Touch