title: The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population.
abstract: BACKGROUND
  Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the association of chromosome 9p21 single nucleotide polymorphisms (SNPs): rs2383207, rs10757278, and rs10757274 with the risk and severity of CAD among Arab population.
  
  
  METHODS
  A prospective observational case-control study was conducted between 2011 and 2012, in which 236 patients with CAD were recruited from the Heart Hospital in Qatar. Patients were categorized according to their coronary angiographic findings. Also, 152 healthy volunteers were studied to determine if SNPs are associated with risk of CAD. All subjects were genotyped for SNPs (rs2383207, rs2383206, rs10757274 and rs10757278) using allele-specific real-time polymerase chain reaction.
  
  
  RESULTS
  Patients with CAD had a mean age of 57 ± 10; of them 77% were males, 54% diabetics, and 25% had family history of CAD. All SNPs were in Hardy-Weinberg equilibrium except rs2383206, with call rate >97%. After adjusting for age, sex and body mass index, the carriers of GG genotype for rs2383207 have increased the risk of having CAD with odds ratio (OR) of 1.52 (95% confidence interval [CI] = 1.01-2.961, P = 0.046). Also, rs2383207 contributed to CAD severity with adjusted OR 1.80 (95% CI = 1.04-3.12, P = 0.035) based on the dominant genetic model. The other SNPs (rs10757274 and rs10757278) showed no significant association with the risk of CAD or its severity.
  
  
  CONCLUSIONS
  Among Arab population in Qatar, only G allele of rs2483207 SNP is significantly associated with risk of CAD and its severity.
authors.affiliation: Department of Clinical medicine, Weill Cornell Medical School, Doha, Qatar ; Department of Surgery, Clinical Research, Hamad General Hospital, Doha, Qatar ; Department of Internal Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt.
authors.forename: Ayman A
authors.initials: AA
authors.lastname: El-Menyar
authors.affiliation: Department of Health Sciences, CAS, Qatar University, Doha, Qatar ; Department of Physiology, Faculty of Medicine, Al-Mansoura, Egypt.
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Rizk
authors.affiliation: Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Awad
authors.initials: A
authors.lastname: Al-Qahtani
authors.affiliation: Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Fahad
authors.initials: F
authors.lastname: AlKindi
authors.affiliation: Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elyas
authors.affiliation: Department of Internal Medicine, Al Emadi Hospital, Doha, Qatar.
authors.forename: Fathi
authors.initials: F
authors.lastname: Farag
authors.affiliation: Department of Health Sciences, CAS, Qatar University, Doha, Qatar.
authors.forename: Fadheela Dad
authors.initials: FD
authors.lastname: Bakhsh
authors.affiliation: Department of Health Sciences, CAS, Qatar University, Doha, Qatar.
authors.forename: Samah
authors.initials: S
authors.lastname: Ebrahim
authors.affiliation: Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Emad
authors.initials: E
authors.lastname: Ahmed
authors.affiliation: Department of Clinical Chemistry, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Mooza
authors.initials: M
authors.lastname: Al-Khinji
authors.affiliation: Department of Surgery, Vascular Surgery, Hamad General Hospital, Doha, Qatar.
authors.forename: Hassan
authors.initials: H
authors.lastname: Al-Thani
authors.affiliation: Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Jassim Al
authors.initials: JA
authors.lastname: Suwaidi
keywords: Chromosome 9p21; Qatar; coronary artery disease; single nucleotide polymorphisms