title: miRNA-214: expression, therapeutic and diagnostic potential in cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that negatively regulate gene expression by binding to the 3' untranslated region of their target mRNAs. Recent work supports a role for miRNAs in the initiation and progression of human cancer. miRNA-214 not only mediates differentiation, senescence, angiogenesis, cell migration and virus replication but also acts as a tumor suppressor gene and oncogene. Increasing evidence indicates that miRNA-214 may serve as a biomarker in some cancer types. The aim of this review is to highlight and clarify the complexity of miRNA-214 activity, emphasizing its significant therapeutic and diagnostic potential.
authors.affiliation: Department of Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang - China.
authors.forename: Hengpeng
authors.initials: H
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Nuo
authors.initials: N
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D016922:Cellular Senescence; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism / Q000627:therapeutic use; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000235:genetics; D009857:Oncogenes
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs