title: A deeper look into Comet--implementation and features.
abstract: The Comet database search software was initially released as an open source project in late 2012. Prior to that, Comet existed as the University of Washington's academic version of the SEQUEST database search tool. Despite its availability and widespread use over the years, some details about its implementation have not been previously disseminated or are not well understood. We address a few of these details in depth and highlight new features available in the latest release. Comet is freely available for download at http://comet-ms.sourceforge.net or it can be accessed as a component of a number of larger software projects into which it has been incorporated. Graphical Abstract ᅟ.
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA. engj@uw.edu.
authors.forename: Jimmy K
authors.initials: JK
authors.lastname: Eng
authors.affiliation: Institute for Systems Biology, Seattle, WA, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hoopmann
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA.
authors.forename: Tahmina A
authors.initials: TA
authors.lastname: Jahan
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA.
authors.forename: Jarrett D
authors.initials: JD
authors.lastname: Egertson
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA.
authors.forename: William S
authors.initials: WS
authors.lastname: Noble
authors.affiliation: Department of Genome Sciences, University of Washington, Seattle, WA, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: MacCoss
mesh_terms: D000465:Algorithms; D030562:Databases, Protein; D040901:Proteomics / Q000379:methods*; D012984:Software; D053719:Tandem Mass Spectrometry / Q000379:methods*
keywords: Comet; Database search; MS/MS