title: Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases.
abstract: Polymeric nanoparticles could be promising drug delivery systems to treat neurodegenerative diseases. Among the various methods of nanoparticle preparation, nano-emulsion templating was used in the present study to prepare galantamine-loaded nano-emulsions by a low-energy emulsification method followed by solvent evaporation to obtain galantamine-loaded polymeric nanoparticles. This approach was found to be suitable because biocompatible, biodegradable and safe nanoparticles with appropriate features (hydrodynamic radii around 20 nm, negative surface charge and stability higher than 3 months) for their intravenous administration were obtained. Encapsulation efficiencies higher than 90 wt% were obtained with a sustained drug release profile as compared to that from aqueous and micellar solutions. The enzymatic activity of the drug was maintained at 80% after its encapsulation into nanoparticles that were non-cytotoxic at the required therapeutic concentration. Therefore, novel galantamine-loaded polymeric nanoparticles have been designed for the first time using the nano-emulsification approach and showed the appropriate features to become advanced drug delivery systems to treat neurodegenerative diseases.
authors.affiliation: Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Spain.
authors.forename: C
authors.initials: C
authors.lastname: Fornaguera
authors.forename: N
authors.initials: N
authors.lastname: Feiner-Gracia
authors.forename: G
authors.initials: G
authors.lastname: Calderó
authors.forename: M J
authors.initials: MJ
authors.lastname: García-Celma
authors.forename: C
authors.initials: C
authors.lastname: Solans
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D004655:Emulsions; D005702:Galantamine / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry / Q000494:pharmacology; D053758:Nanoparticles / Q000737:chemistry*; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000378:metabolism; D011100:Polyglycolic Acid / Q000737:chemistry / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D002800:Cholinesterase Inhibitors; D004337:Drug Carriers; D004655:Emulsions; D005702:Galantamine; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid