title: OS108. Preeclamptic women display salt sensitivity and cardiovascular damage before their menopause.
abstract: BACKGROUND
  Salt sensitivity is an important cardiovascular risk factor. It has been shown that preeclamptic (PEC) women may not be totally cured after the delivery and keep a higher cardiovascular risk than nonPEC women.
  
  
  OBJECTIVE
  We aimed to study the salt sensitivity of the blood pressure in women with a history of severe preeclamspia and women with no history of hypertensive complications.The design was a case control study with intervention, including 42 women recruited 5 to 17 years following delivery.
  
  
  METHODS
  21 women having suffered from a severe preeclampsia before 34 weeks of pregnancy and 19 age, race matched controls women,were randomized to follow for one week a low salt (LS) diet and a high salt (HS) diet (adding 6g NACL/d to usual diet). On day seven of each dietary period, 24h ambulatory blood pressure was recorded, and 24h urine collected in order to measure sodium excretion.Salt sensitivity was assigned if the mean 24h blood pressure increased by ⩾ 3mmHg on a high- compared with a low-salt diet.
  
  
  RESULTS
  Preeclamptic women were aged 39.1(24-49) and controls 40.1(29-49), p=NS.Two of the PEC women already suffered from a cardiovascular event (2coronary events). The PEC women showed a significant increase of the BP and standard deviation (SD) of the BP compared to the controls.10 (47.6%) preeclamptic women showed salt sensitivity (odd ratio 5.4, 95% CI 0.972-30.601;P=0.042).Recurrent preeclampsia was associated with a significantly high risk to salt sensitivity status (OR 5; 95% confidence interval 1.1-31.6).
  
  
  CONCLUSIONS
  Severe PEC women display already salt sensitivity of the blood pressure before their menopause and increased variability of the BP. Recurrent preeclampsia is a high risk factor for salt sensitivity and could allow to target this high-risk group at an early stage for preventive measures for cardiovascular disease.
authors.affiliation: Obstetrics, University Hospital Geneva, Geneva 4, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Martillotti
authors.affiliation: Obstetrics, University Hospital Geneva, Geneva 4, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Boulvain
authors.affiliation: Hypertension Unit, University Hospital, Geneva 4, Switzerland.
authors.forename: G
authors.initials: G
authors.lastname: Wagner
authors.affiliation: Obstetrics, University Hospital Geneva, Geneva 4, Switzerland.
authors.forename: V
authors.initials: V
authors.lastname: Othenin-Girard
authors.affiliation: Nephrology, University Hospital, Geneva 4, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Saudan
authors.affiliation: Obstetrics, University Hospital Geneva, Geneva 4, Switzerland.
authors.forename: O P
authors.initials: OP
authors.lastname: Irion
authors.affiliation: Hypertension Unit, University Hospital, Geneva 4, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Pechère-Bertschi