title: Prognostic role of hormone receptors in endometrial cancer: a systematic review and meta-analysis.
abstract: BACKGROUND
  The aim of this study was to summarize the global predicting role of hormone receptors for survival in endometrial cancer.
  
  
  METHODS
  Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall survival (OS), cancer-specific survival (CSS), or progression-free survival (PFS) in patients with elevated levels of estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2) with those in patients with lower levels. The combined hazard ratios of ER, PR, and HER2 for survival were calculated.
  
  
  RESULTS
  A total of 98 studies were included for meta-analysis (44 for ER, 38 for PR, and 16 for HER2). Higher levels of either ER or PR could significantly indicate better survival. The pooled hazard ratios (HRs) of ER for OS, CSS, and PFS were 0.75 (95% CI, 0.68-0.83), 0.45 (95% CI, 0.33-0.62), and 0.66 (95% CI, 0.52-0.85), respectively. The combined HRs of PR for OS, CSS, and PFS reached 0.63 (95% CI, 0.56-0.71), 0.62 (95% CI, 0.42-0.93), and 0.45 (95% CI, 0.30-0.68), respectively. In contrast, elevated levels of HER2 could predict worse outcome with a HR of 1.98 (95% CI, 1.49-2.62) for OS, and a HR of 2.26 (95% CI, 1.57-3.25) for PFS.
  
  
  CONCLUSIONS
  In patients with endometrial cancer, higher level of ER and PR predicted favorable survival, and increased level of HER2 was associated with poorer survival. All of the three hormone receptors had prognostic value for survival.
authors.affiliation: Department of Minimally Invasive Gynecologic Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Changle Road #536, Shanghai, 200040, People's Republic of China. yanlizhang07@163.com.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Minimally Invasive Gynecologic Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Changle Road #536, Shanghai, 200040, People's Republic of China. hendryz@gmail.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China. 1044018786@qq.com.
authors.forename: Changguo
authors.initials: C
authors.lastname: Gong
authors.affiliation: Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China. 814197083@qq.com.
authors.forename: Fengmei
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China. terry.hejing@gmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, People's Republic of China. james_zhangwei@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Life Science, East China Normal University, North Zhongshan Road #3663, Shanghai, People's Republic of China. ylzhao@imet.ecnu.edu.cn.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Minimally Invasive Gynecologic Surgery, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Changle Road #536, Shanghai, 200040, People's Republic of China. sunjing61867@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human