title: Association between aldosterone synthase (CYP11B2) -344C/T polymorphism and atrial fibrillation among Han and Kazak residents of the Xinjiang region.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is one the most common and complex types of clinical arrhythmia syndromes. In recent years, an association between CYP11B2 gene polymorphisms and atrial myocardial fibrosis has received a significant amount of attention. This study explores the relationship between CYP11B2 gene-344C/T polymorphism and AF among Kazak and Han residents in the Xinjiang region and further clarifies the molecular mechanisms of atrial fibrillation.
  
  
  METHODS
  The study is a case-control study using traditional methods. We selected 156 Kazak and 203 Han patient cases in the Xinjiang region who had non-valvular atrial fibrillation as well as 307 Kazak and 418 Han cases of non-AF patients as a control group. Blood samples were collected, and DNA was extracted from the peripheral blood samples. The presence of the CYP11B2 gene-344C/T polymorphism was determined using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP). Differences in the genotypes and allele distributions among the 2 groups were compared using Statistical Package for Social Science (SPSS) 17.0 statistical software. Student's t test, the chi-squared test and logistic regression methods were used for the data analysis.
  
  
  RESULTS
  The genotypes of both ethnic groups followed a Hardy-Weinberg genetic equilibrium distribution. The 2 patient groups, compared with their respective control groups, showed significant dominant models in CYP11B2 gene-344C/T polymorphism genotype frequency and B1 allele frequency (P<0.05). The frequencies of the CYP11B2 gene-344C/T polymorphism in the Kazak patient group were higher compared with the control groups (P<0.05). The frequencies of the CYP11B2 gene-344C/T polymorphisms in the Han patient group was also higher compared with the control group (P<0.05). Logistic regression analysis showed that the frequencies of the CYP11B2 gene-344C/T genotypes were significantly different between the Kazak and Han patient groups and the control groups.
  
  
  CONCLUSIONS
  CYP11B2 gene -344C/T polymorphism is associated with AF.
authors.affiliation: Department of Outpatient, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China ; College of Public Health, Xiniiang Medical University Urumqi, Xinjiang, China.
authors.forename: Wu-Hong
authors.initials: WH
authors.lastname: Lu
authors.affiliation: The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Maerjiaen
authors.initials: M
authors.lastname: Bayike
authors.affiliation: College of Public Health, Xiniiang Medical University Urumqi, Xinjiang, China.
authors.forename: Ji-Wen
authors.initials: JW
authors.lastname: Liu
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Coronary Artery Disease, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Yang
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Liu
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.forename: Peng-Yi
authors.initials: PY
authors.lastname: He
authors.affiliation: Department of Comprehensive Cardiology, The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China.
authors.lastname: Muhuyati
keywords: Atrial fibrillation; CYP11B2 gene polymorphism; aldosterone