title: Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism.
abstract: The objective of this study was to investigate serum cystatin C (sCysC) and urinary cystatin C (uCysC) in cats with hyperthyroidism and cats with feline immunodeficiency virus (FIV).
  
  
  
  Thirty cats with FIV, 26 hyperthyroid cats and 28 healthy cats were included. sCysC and uCysC:creatinine (uCysC/uCr) ratio were measured with a human particle-enhanced nephelometric immunoassay, previously validated for feline CysC measurement. Routine renal variables (serum creatinine [sCr], urine specific gravity, urinary protein:creatinine ratio [UPC]) were also measured in the three groups.
  
  
  
  Cats with hyperthyroidism had significantly higher sCysC and higher uCysC/uCr ratio, lower sCr and a higher UPC than healthy cats. Cats with FIV infection did not show a significantly higher sCysC concentration but had a significantly higher sCr and UPC than healthy cats. uCysC could be detected in only four of them.
  
  
  
  This study demonstrated that sCysC is increased in cats with hyperthyroidism, in contrast with sCr, but not in cats with FIV. Many hyperthyroid cats, but only four cats with FIV, had an elevated uCysC/uCr ratio. Further studies may reveal if uCysC might be a valuable marker for tubular dysfunction in cats.
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium liesbeth.ghys@ugent.be.
authors.forename: Liesbeth F E
authors.initials: LFE
authors.lastname: Ghys
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Dominique
authors.initials: D
authors.lastname: Paepe
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Elien R L
authors.initials: ERL
authors.lastname: Taffin
authors.affiliation: Department of Medical Imaging and Orthopaedics of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Vandermeulen
authors.affiliation: Department of Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke.
authors.forename: Luc
authors.initials: L
authors.lastname: Duchateau
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Pascale M Y
authors.initials: PMY
authors.lastname: Smets
authors.affiliation: Department of Clinical Chemistry, Microbiology and Immunology, Faculty of Health Medicine and Life Sciences, Ghent University, Ghent, Belgium.
authors.forename: Joris
authors.initials: J
authors.lastname: Delanghe
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Daminet
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002371:Cat Diseases / Q000097:blood* / Q000652:urine*; D002415:Cats; D055316:Cystatin C / Q000097:blood* / Q000652:urine*; D016181:Feline Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000652:urine*; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000652:urine / Q000662:veterinary*; D008297:Male
chemical_list: D015415:Biomarkers; D055316:Cystatin C