title: On contrast mechanisms in p-space imaging.
abstract: The effects of microstructure on susceptibility mapping have recently received increasing attention. In this work, the capability of p-space imaging to resolve subvoxel structure and susceptibility is assessed.
  
  
  
  In a simulation study, the p-space contrast of axon bundles comprised of hollow cylinders is investigated. Various axon and susceptibility distributions are considered and compared with the corresponding case of a voxel with homogeneous substructure of the order of the voxel size.
  
  
  
  MR signal behavior for p-space imaging of a voxel containing axon bundles and a voxel containing homogeneous substructure are nearly identical.
  
  
  
  p-Space imaging resolves subvoxel structure of the order of the voxel size. Due to dephasing effects, strong susceptibility variations alter p-space contrast. However, p-space contrast is not directly linked to the susceptibility of the axon compartment. Magn Reson Med 75:2526-2533, 2016. © 2015 Wiley Periodicals, Inc.
authors.affiliation: Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Straub
authors.affiliation: Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Ladd
authors.affiliation: Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wetscherek
authors.affiliation: Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Frederik B
authors.initials: FB
authors.lastname: Laun
mesh_terms: D016880:Anisotropy; D001369:Axons / Q000502:physiology; D003198:Computer Simulation; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012815:Signal Processing, Computer-Assisted
chemical_list: D003287:Contrast Media
keywords: magnetic resonance imaging; magnetic susceptibility anisotropy; p-space