title: suPAR: A New Biomarker for Cardiovascular Disease?
abstract: The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events.
authors.affiliation: Department of Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. Electronic address: gethin.william.hodges@regionh.dk.
authors.forename: Gethin W
authors.initials: GW
authors.lastname: Hodges
authors.affiliation: Department of Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
authors.forename: Casper N
authors.initials: CN
authors.lastname: Bang
authors.affiliation: Department of Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark; Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden.
authors.forename: Kristian
authors.initials: K
authors.lastname: Wachtell
authors.affiliation: Clinical Research Centre, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.
authors.forename: Jesper
authors.initials: J
authors.lastname: Eugen-Olsen
authors.affiliation: Department of Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.
authors.forename: Jørgen L
authors.initials: JL
authors.lastname: Jeppesen
mesh_terms: D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*
chemical_list: D015415:Biomarkers; D055293:Receptors, Urokinase Plasminogen Activator