title: Regulation of cytokinesis and its clinical significance.
abstract: Dysregulation of the cell cycle leads to polyploid cells, which are classified into mononuclear or binuclear polyploid cells depending on the number of nuclei. Polyploidy is common in plants and in animals. Physiologically, polyploidy and binucleation are differentiation markers and also features of the aging process. In fact, although they provide multiple copies of genes required for survival, a negative correlation between growth capacity and polyploidy has been reported, and thus, suppression or reversal of this phenomenon may be a growth advantage. On the other hand, unscheduled polyploidization may cause genomic instability that might lead to neoplastic aneuploidy. The aim of this review is to analyze the mechanisms that lead to polyploidy, and particularly binucleation, and highlight the potential of ploidy as a marker of illness severity or the success of the adaptive response for an injury, with special emphasis in the liver under physiological and pathological conditions. Hepatocyte binucleation occurs in late fetal development and postnatal maturation, especially after weaning via phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt). It also increases upon aging of the liver as well as in liver cirrhosis and cancer. Liver binucleation mainly indicates the severity of the damage. Furthermore, the eventual increase in hepatocyte binucleation points out compensatory proliferation associated with liver injury. Ploidy conveyor would also permit hepatocyte adaptation to xenobiotic or nutritional injury. In contrast, polyploidy is a feature of many human cancers, and it may predispose to genomic instability and generation of aneuploidization that play a major role in carcinogenesis. Finally, a better understanding of the polyploidization process is needed in order to approach clinical research but also, to get deeper knowledge of cell cycle control. The fascinating regulation of cell cycle in liver and the generation and reversal of ploidies will provide more clues for the mystery of liver regeneration.
authors.affiliation: a Department of Physiology and.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Tormos
authors.forename: Raquel
authors.initials: R
authors.lastname: Taléns-Visconti
authors.forename: Juan
authors.initials: J
authors.lastname: Sastre
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002478:Cells, Cultured; D048749:Cytokinesis; D022781:Hepatocytes; D006801:Humans; D008113:Liver Neoplasms; D008115:Liver Regeneration; D051379:Mice; D018345:Mice, Knockout
keywords: Binucleation; cell cycle; cytokinesis; hepatocarcinoma; hepatocyte; liver; liver regeneration; ploidy