title: Predictive value of cyclooxygenase-2 over expression for identifying prostate cancer from benign prostatic hyperplasia in prostate biopsy specimens.
abstract: BACKGROUND
  We studied cyclooxygenase-2 (COX-2) immunohistochemical staining intensity both in prostatic biopsy and surgical samples of patients with prostate cancer to determine if it might provide prognostic information for the decision of re-biopsy indication.
  
  
  METHODS
  Twenty-eight patients undergone radical prostatectomy whose final pathologic examination revealed prostatic adenocarcinoma were included in the study. Twelve patients with BPH in their pathological examination of both prostatic biopsy and open prostatectomy were considered as a control group. Intensity of COX-2 receptor was examined with immunohistochemical staining according to standard techniques.
  
  
  RESULTS
  Positive COX-2 receptor staining was obtained 89.3% of biopsy samples and 93% of surgical samples in all cancer patients. The rate of agreement in COX-2 receptor staining of biopsy samples and radical prostatectomy samples was 76% in same patients (P=0.54). Similarly, the COX-2 receptor levels in biopsy specimens of patients with BPH open surgery compared with samples of the agreement still rate was 41% (P=0.41). Prostate cancer exchanging COX-2 receptor levels in patients with biopsy specimens in patients with BPH were found significantly more (P=0.008).
  
  
  CONCLUSIONS
  In this study the feasibility of presence of COX-2 receptor staining in biopsy samples was shown. We have also demonstrated that COX-2 staining intensity was higher in prostatic biopsy samples of patients with prostatic cancer than patients with BPH. This leads a conclusion that, higher COX-2 expression levels in biopsy specimens may be used to decide re-biopsy in borderline preoperative PSA levels as well as in the cases with suspicious pathological findings for cancer.
authors.affiliation: Department of Urology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey - dryasinceylan@yahoo.com.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Ceylan
authors.forename: Murat
authors.initials: M
authors.lastname: Lekili
authors.forename: Talha
authors.initials: T
authors.lastname: Muezzinoglu
authors.forename: Nalan
authors.initials: N
authors.lastname: Nese
authors.forename: Aydin
authors.initials: A
authors.lastname: Isisag
mesh_terms: D000368:Aged; D001706:Biopsy; D051546:Cyclooxygenase 2 / Q000032:analysis / Q000096:biosynthesis*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D051546:Cyclooxygenase 2