title: Novel macromolecules derived from coumarin: synthesis and antioxidant activity.
abstract: The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products. A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the creation of a macromolecules have 2-aminothiazolidin-4-one. The molecular structures of the compounds were characterized by the Fourier transformation infrared and Nuclear magnetic resonance spectroscopies, in addition to CHN analysis. The scavenging abilities of new compounds against stable DPPH radical (DPPH•) and hydrogen peroxide were done and the results show that the compounds exhibited high antioxidant activates.
authors.affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Al-Amiery
authors.affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.
authors.forename: Yasameen K
authors.initials: YK
authors.lastname: Al-Majedy
authors.affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.
authors.forename: Abdul Amir H
authors.initials: AA
authors.lastname: Kadhum
authors.affiliation: Department of Chemical and Process Engineering, Universiti Kebangsaan Malaysia (UKM), Bangi, Selangor 43000, Malaysia.
authors.forename: Abu Bakar
authors.initials: AB
authors.lastname: Mohamad
mesh_terms: D015110:4-Hydroxycoumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010084:Oxidation-Reduction; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D015110:4-Hydroxycoumarins; D000975:Antioxidants; D003374:Coumarins; D016166:Free Radical Scavengers; C030123:coumarin; D006861:Hydrogen Peroxide; C068805:4-hydroxycoumarin