title: Dectin-2 polymorphism associated with pulmonary cryptococcosis in HIV-uninfected Chinese patients.
abstract: Dectin-2 is a C-type lectin receptor that can recognize critical structures of fungi and involve in the host immune response after pulmonary fungal infections. We aimed to investigate the association between Dectin-2 genetic polymorphisms and cryptococcosis among a series of human immunodeficiency virus (HIV)-uninfected Chinese patients. In this case control study, a total of 251 patients with cryptococcosis and 464 healthy controls were included. One tag-single nucleotide polymorphism (SNP) (rs11045418) located at 5'-flanking region of Dectin-2 gene was selected and genotyped in this study. Among 251 patients, there were 108 (43%) meningitis patients including 73 (67.7%) healthy ones, 74 (29.5%) pulmonary infected patients including 49 (66.2%) healthy ones, and 69 (27.5%) patients with both neural and pulmonary infection including 38 (55.1%) immunocompetent ones. One hundred and forty-three (74 plus 69) patients with pulmonary cryptococcosis and 177 (108 plus 69) patients with cryptococcal meningitis were compared with controls, respectively. Three samples from 143 pulmonary infected patients failed in genotyping. There was a significant difference between 86 immunocompetent pulmonary infected patients and controls in the overdominant model (C/T vs. T/T + C/C; OR, 0.59; 95%CI, 0.37-0.94; P, .026). Similar but not significant difference was found between the overall pulmonary infected patients and the controls in the overdominant model (OR, 0.77; 95%CI, 0.52-1.12; P, .17). No such difference was found between controls and patients with cryptococcal meningitis. Our study firstly showed a genetic association between Dectin-2 and pulmonary cryptococcosis.
authors.affiliation: Intensive Care Unit, Zhejiang Provincial People's Hospital, Hangzhou, China Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Hu
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Rui-Ying
authors.initials: RY
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Ya-Hui
authors.initials: YH
authors.lastname: Cao
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Yan-Qiong
authors.initials: YQ
authors.lastname: Chen
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Hua-Zhen
authors.initials: HZ
authors.lastname: Zhao
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Ji-Qin
authors.initials: JQ
authors.lastname: Wu
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Weng
authors.affiliation: No. 1 Hospital of China Medical University.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Gao
authors.affiliation: Intensive Care Unit, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China zhulp@fudan.edu.cn.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D003453:Cryptococcosis / Q000235:genetics* / Q000276:immunology*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D037181:Lectins, C-Type; C445340:dectin-2, mouse
keywords: Dectin-2; cryptococcosis; polymorphism