title: Divergent Functionalization of Indoles with Acryloyl Silanes via Rhodium-Catalyzed C-H Activation.
abstract: A protocol enabled by rhodium-catalyzed C-H functionalization of indoles with acryloyl silanes was developed, providing a convenient and highly effective method for the synthesis of functionalized acylsilane derivatives. By tuning the reaction condition, this C-H-activation-initiated reaction proceeds divergently with acryloyl silianes to selectively afford alkylation or alkenylation products via hydroarylation or oxidative cross-coupling, respectively. The mild reaction conditions employed in both cases enable the tolerance of a wide scope of functionalities as well as high reaction efficiency. Furthermore, polycyclic indole derivatives were easily accessed from 2-alkenylation products through a visible-light-induced reaction cascade.
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lu
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.|‡Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637616, Singapore.
authors.forename: Chao
authors.initials: C
authors.lastname: Feng
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.|‡Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637616, Singapore.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh