title: PKCδ stabilizes TAp63 to promote cell apoptosis.
abstract: PKCδ and p63 are respectively reported to play important roles in cell apoptosis. But there is no report on interaction between them in regulation of apoptosis. In the present study, we found that PKCδ can directly associate and up-regulate TA isoforms of p63 (TAp63) proteins via increasing their stability. PKCδ kinase activity and Thr157 site in TAp63 are crucial for this PKCδ-induced accumulation of TAp63. PKCδ can also enhance TAp63-mediated transcription and cell apoptosis. Taken together, our data indicate that PKCδ phosphorylates TAp63 proteins at Thr157 to stabilize them and promote cell apoptosis.
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Decai
authors.initials: D
authors.lastname: Li
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Li
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Qiongqiong
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Ren
authors.affiliation: Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Chengdu 610065, China. Electronic address: yzhang2010@scu.edu.cn.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D019943:Amino Acid Substitution; D017209:Apoptosis; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016297:Mutagenesis, Site-Directed; D050505:Mutant Proteins / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010766:Phosphorylation; D054730:Protein Interaction Domains and Motifs; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011493:Protein Kinase C / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D013912:Threonine / Q000737:chemistry; D014157:Transcription Factors / Q000819:agonists* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000819:agonists* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: C489427:MYC protein, human; D050505:Mutant Proteins; D020033:Protein Isoforms; D016271:Proto-Oncogene Proteins c-myc; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; C495901:TP53 protein, human; C115051:TP63 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D013912:Threonine; C087857:protein kinase C gamma; D011493:Protein Kinase C
keywords: Apoptosis; PKCδ; TA isoforms of p63