title: Polycaprolactone-based in situ implant containing curcumin-PLGA nanoparticles prepared using the multivariate technique.
abstract: Studies on the effect of curcumin/PLGA ratio (CPR), stabilizer (PVA) concentration, homogenization speed, homogenization time, and sonication time on mean particle size (MPS) and percentage drug encapsulation (PDE) were performed using the multivariate technique. MPS and PDE were found to be more dependent on the interaction of sonication time with the other variables. Curcumin was released in a sustained manner from curcumin-PLGA nanoparticles (CPN). CPN improved the survival rate of Ehrlich ascites carcinoma (EAC)-bearing mice and controlled the EAC-induced change in hematological parameters. Histopathology of vital organs showed that the formulation was safe. Polycaprolactone was used in preparing an in situ implant containing CPN.
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Kasinathan
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Muthukumar
authors.initials: M
authors.lastname: Amirthalingam
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Neetinkumar D
authors.initials: ND
authors.lastname: Reddy
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Meenashi B
authors.initials: MB
authors.lastname: Vanthi
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Subrahmanyam M
authors.initials: SM
authors.lastname: Volety
authors.affiliation: a Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Josyula Venkata
authors.initials: JV
authors.lastname: Rao
mesh_terms: D000818:Animals; D003474:Curcumin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004343:Drug Implants / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004343:Drug Implants; D011091:Polyesters; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003474:Curcumin
keywords: Box–Behnken design; Ehrlich ascites carcinoma; design of experiment; experimental design; factorial design; quality by design