title: Modeling of closed-loop recycling liquid-liquid chromatography: Analytical solutions and model analysis.
abstract: In closed-loop recycling (CLR) chromatography, the effluent from the outlet of a column is directly returned into the column through the sample feed line and continuously recycled until the required separation is reached. To select optimal operating conditions for the separation of a given feed mixture, an appropriate mathematical description of the process is required. This work is concerned with the analysis of models for the CLR separations. Due to the effect of counteracting mechanisms on separation of solutes, analytical solutions of the models could be helpful to understand and optimize chromatographic processes. The objective of this work was to develop analytical expressions to describe the CLR counter-current (liquid-liquid) chromatography (CCC). The equilibrium dispersion and cell models were used to describe the transport and separation of solutes inside a CLR CCC column. The Laplace transformation is applied to solve the model equations. Several possible CLR chromatography methods for the binary and complex mixture separations are simulated.
authors.affiliation: Kurnakov Institute of General & Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 31, Moscow 119991, Russia. Electronic address: kost@igic.ras.ru.
authors.forename: Artak E
authors.initials: AE
authors.lastname: Kostanyan
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D002853:Chromatography, Liquid; D008962:Models, Theoretical; D012996:Solutions
chemical_list: D012996:Solutions
keywords: Closed-loop recycling liquid–liquid chromatography; Equilibrium dispersion and cell models; Peak and chromatogram equations; Resolution; Separation of binary and complex mixtures