title: Pitfalls and mimickers on (18)F-FDG-PET/CT in peritoneal carcinomatosis from colorectal cancer: An analysis from 37 patients.
abstract: BACKGROUND
  Optimal selection is critical in patients with peritoneal carcinomatosis (PC) in whom curative cytoreductive surgery can be anticipated. (18)F-FDG-PET/CT may result in false-positive findings that may eliminate patients for whom cytoreductive surgery would be beneficial.
  
  
  OBJECTIVE
  To determine the rate of false-positive findings on (18)F-FDG-PET/CT and clarify their causes in patients with suspected PC from colorectal cancer.
  
  
  METHODS
  A retrospective analysis of 37 patients with suspected PC from colorectal cancer who had (18)F-FDG-PET/CT before cytoreductive surgery was performed to determine the rate and the causes of false-positive findings. (18)F-FDG-PET/CT was considered falsely positive when no tumor was found at surgery, histopathological analysis and follow-up.
  
  
  RESULTS
  False-positive findings were observed in four patients, yielding a 11% (95%CI: 3-25%) false-positive rate on a per-patient basis. The causes of false-positives were elucidated in two patients (surgical mesh after umbilical hernia repair and one foreign body granuloma).
  
  
  CONCLUSIONS
  False-positive findings on (18)F-FDG-PET/CT are observed in 11% of patients with suspected PC from colorectal cancer. Familiarity with false-positive findings would result in more accurate selection of patients candidates to cytoreductive surgery.
authors.affiliation: Surgical Oncologic and Digestive Unit, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Audollent
authors.affiliation: Surgical Oncologic and Digestive Unit, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France; INSERM U965, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: C
authors.initials: C
authors.lastname: Eveno
authors.affiliation: Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France; INSERM U965, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Department of Abdominal Imaging, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: A
authors.initials: A
authors.lastname: Dohan
authors.affiliation: Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France; Department of Nuclear Medicine, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: L
authors.initials: L
authors.lastname: Sarda
authors.affiliation: Surgical Oncologic and Digestive Unit, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: I
authors.initials: I
authors.lastname: Jouvin
authors.affiliation: Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France; INSERM U965, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Department of Abdominal Imaging, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. Electronic address: philippe.soyer@lrb.aphp.fr.
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.affiliation: Surgical Oncologic and Digestive Unit, hôpital Lariboisière, Assistance publique-Hôpitaux de Paris, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France; Université Paris-Diderot, Sorbonne Paris Cité, 10, rue de Verdun, 75010 Paris, France; INSERM U965, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France.
authors.forename: M
authors.initials: M
authors.lastname: Pocard
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D065426:Cytoreduction Surgical Procedures; D005189:False Positive Reactions; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG-PET/CT; Colorectal cancer; False-positive findings; HIPEC; Hyperthermic intraperitoneal chemotherapy; Imaging; Peritoneal carcinomatosis