title: Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study.
abstract: OBJECTIVE
  In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity.
  
  
  METHODS
  A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline.
  
  
  RESULTS
  Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower.
  
  
  CONCLUSIONS
  The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group.
authors.affiliation: Department of Urology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Sung Gon
authors.initials: SG
authors.lastname: Park
authors.affiliation: Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Byung Ha
authors.initials: BH
authors.lastname: Chung
authors.affiliation: Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Urology, Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Jong Kwan
authors.initials: JK
authors.lastname: Park
authors.affiliation: Department of Urology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Kwangsung
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Urology, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Cheon
authors.affiliation: Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea.
authors.forename: Kyung Seop
authors.initials: KS
authors.lastname: Lee
authors.affiliation: Department of Urology, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Hyung-Jee
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Urology, Inha University College of Medicine, Incheon, Korea.
authors.forename: Do-Hwan
authors.initials: DH
authors.lastname: Seong
authors.affiliation: Department of Urology, Seoul National University Hospital, Seoul, Korea.
authors.forename: Seung-June
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Sae Woong
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea.
authors.forename: Ji Youl
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Urology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Seol Ho
authors.initials: SH
authors.lastname: Choo
authors.affiliation: Department of Urology, Ajou University School of Medicine, Suwon, Korea.
authors.forename: Jong Bo
authors.initials: JB
authors.lastname: Choi
keywords: Heart Rate; Lower Urinary Tract Symptoms; Prostatic Hyperplasia; Sympathetic Nervous System