title: Acellular Dermal Matrix Use in Cleft Palate and Palatal Fistula Repair: A Potential Benefit?
abstract: BACKGROUND
  In cleft palate repair, anatomically oriented, tension free, atraumatic total closure is the key to achieve a normal speech consecutive to a sufficient velopharyngeal closure and also to prevent postoperative fistula development. In this clinical study, we review our experience with acellular dermal matrix (ADM) which was used as an adjunct to facilitate difficult cleft palate and palatal fistula closure.
  
  
  METHODS
  From October 2009 till December 2013, primary cleft palate and fistula repairs in which ADM was used were culled from the cleft surgery files. Acellular dermal matrix was used as an extra layer in between palatal flaps of primary repairs and as a sandwiched sheet separating the flaps used to repair fistulas. In addition to patient, cleft and fistula demographics, records were evaluated for sizes, fistula development, fistula recurrence, extrusion, exposure, and infection.
  
  
  RESULTS
  Acellular dermal matrix was used in 35 patients with palatal clefts of mean size 15 ± 4  mm and in 15 palatal fistulas. Two-flap palatoplasty technique was the dominant technique for the palate repair. Fistula rate for the palate repair was 8.5% and fistula recurrence rate was 20%. Mean follow-up for the palate and fistula repair patients was 29 ± 15 months and 32 ± 11 months, respectively. In two cases of palatoplasty group and in four cases of fistula repair group, ADM was exposed resulting in total extrusion in two fistula cases.
  
  
  CONCLUSIONS
  In this ongoing experience of application, ADM has been shown to be a simple, safe, and helpful tool to reduce fistula rate mainly in relatively wide and high tension tenuous cleft palate repairs but less favorable in challenging fistula closure attempts particularly along with poorly vascularized surrounding tissues. However, study design and its results are yet far from strongly recommending routine ADM use in cleft palate surgery.
authors.affiliation: Department of Plastic, Reconstructive and Aesthetic Surgery, Kocaeli University Faculty of Medicine Hospital, Kocaeli, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Agir
authors.forename: Gamze G
authors.initials: GG
authors.lastname: Eren
authors.forename: Emrah K
authors.initials: EK
authors.lastname: Yasar
mesh_terms: D062088:Acellular Dermis; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002972:Cleft Palate / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016155:Oral Fistula / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D013524:Surgical Flaps; D055815:Young Adult