title: Tracking social motivation systems deficits: the affective neuroscience view of autism.
abstract: Abnormal functioning of primary brain systems that express and modulate basic emotional drives are increasingly considered to underlie mental disorders including autism spectrum disorders. We hypothesized that ASD are characterized by disruptions in the primary systems involved in the motivation for social bonding. Twenty adults with ASD were compared to 20 neurotypical participants on the basis of self-reports and clinical assessments, including the Social Anhedonia Scale (SAS) and the Affective Neuroscience Personality Scales (ANPS). ASD diagnosis was related to SAS, as well as to positive (PLAYFULNESS) and negative (FEAR) ANPS-traits. In the overall sample, levels of autistic traits (AQ) were related to SAS and PLAYFULNESS. We argue that PLAYFULNESS could be at the root of social bonding impairments in ASD.
authors.affiliation: Mental Health and Public Health, Inserm, U1178, 75014, Paris, France. arnaud.carre@inserm.fr.|Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. arnaud.carre@inserm.fr.|Université Paris Sud, UniverSud Paris, 91400, Orsay, France. arnaud.carre@inserm.fr.|Université Savoie Mont Blanc, LIPPC2S, 73000, Chambéry, France. arnaud.carre@inserm.fr.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Carré
authors.affiliation: Laboratoire de Neurosciences Cognitives, Inserm, U960, Ecole Normale Supérieure, PSL Research University, 75005, Paris, France. coralie.chevallier@ens.fr.
authors.forename: Coralie
authors.initials: C
authors.lastname: Chevallier
authors.affiliation: Mental Health and Public Health, Inserm, U1178, 75014, Paris, France. laurence.robel@free.fr.|Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. laurence.robel@free.fr.|Université Paris Sud, UniverSud Paris, 91400, Orsay, France. laurence.robel@free.fr.|Hôpital Necker Enfants Malades, Department of Child and Adolescent Psychiatry, Assistance Publique - Hôpitaux de Paris (AP-HP), 75015, Paris, France. laurence.robel@free.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Robel
authors.affiliation: Mental Health and Public Health, Inserm, U1178, 75014, Paris, France. caroline.barry@inserm.fr.|Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. caroline.barry@inserm.fr.|Université Paris Sud, UniverSud Paris, 91400, Orsay, France. caroline.barry@inserm.fr.
authors.forename: Caroline
authors.initials: C
authors.lastname: Barry
authors.affiliation: Mental Health and Public Health, Inserm, U1178, 75014, Paris, France. annesolenemaria@gmail.com.|Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. annesolenemaria@gmail.com.|Université Paris Sud, UniverSud Paris, 91400, Orsay, France. annesolenemaria@gmail.com.|Hôpital Paul Brousse, Eating Disorders Unit, Assistance Publique - Hôpitaux de Paris (AP-HP), 94800, Villejuif, France. annesolenemaria@gmail.com.
authors.forename: Anne-Solène
authors.initials: AS
authors.lastname: Maria
authors.affiliation: Laboratoire de Neurosciences Cognitives, Inserm, U960, Ecole Normale Supérieure, PSL Research University, 75005, Paris, France. lydia.pouga@hotmail.fr.
authors.forename: Lydia
authors.initials: L
authors.lastname: Pouga
authors.affiliation: Hôpital Necker Enfants Malades, Department of Child and Adolescent Psychiatry, Assistance Publique - Hôpitaux de Paris (AP-HP), 75015, Paris, France. anne.philippe@inserm.fr.|Genetics and Epigenetics of Neurometabolic Diseases and Birth Defects, Inserm, U781, 75015, Paris, France. anne.philippe@inserm.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Philippe
authors.affiliation: Hôpital Pitié-Salpétrière, Department of Child and Adolescent Psychiatry, Assistance Publique - Hôpitaux de Paris (AP-HP), 75013, Paris, France. cabinet@dr-pinabel.fr.
authors.forename: François
authors.initials: F
authors.lastname: Pinabel
authors.affiliation: Mental Health and Public Health, Inserm, U1178, 75014, Paris, France. sylvie.berthozlandron@gmail.com.|Université Paris Descartes, Sorbonne Paris Cité, 75006, Paris, France. sylvie.berthozlandron@gmail.com.|Université Paris Sud, UniverSud Paris, 91400, Orsay, France. sylvie.berthozlandron@gmail.com.|Department of Psychiatry for Adolescents & Young Adults, Institut Mutualiste Montsouris, 75014, Paris, France. sylvie.berthozlandron@gmail.com.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Berthoz
mesh_terms: D000328:Adult; D059445:Anhedonia; D001321:Autistic Disorder / Q000503:physiopathology* / Q000523:psychology; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D012919:Social Behavior
keywords: Autism; Emotion; Playfulness; Social anhedonia; Social bonding; Social motivation