title: Antiretroviral Effects on Host Lipoproteins Are Associated With Changes in Hepatitis C Virus (HCV) RNA Levels in Human Immunodeficiency Virus/HCV Coinfected Individuals.
abstract: We evaluated the impact of antiretroviral-induced dyslipidemia on hepatitis C virus (HCV) biogenesis in human immunodeficiency virus (HIV)/HCV coinfected patients. This study used serum samples from antiretroviral-naive HIV/HCV patients initiating their first regimen as part of AIDS Clinical Trials Group study protocols (A5142, A5202). Initiation of antiretrovirals increased most lipoproteins and apolipoproteins. In the multivariable model, changes in apolipoproteins were associated with changes in log10 HCV RNA from baseline to week-24 of therapy. Off-target lipogenic changes need to be considered in the context of liver and other metabolic disease in HIV/HCV patients.
authors.affiliation: Duke Clinical Research Institute ; Duke University Medical Center.
authors.forename: Susanna
authors.initials: S
authors.lastname: Naggie
authors.affiliation: Duke Clinical Research Institute ; Duke University Medical Center.
authors.forename: Keyur
authors.initials: K
authors.lastname: Patel
authors.affiliation: Duke Department of Biostatistics and Bioinformatics, Durham, North Carolina ; Clinical Trial Center , Chang Gung Memorial Hospital , Taoyuan , Taiwan.
authors.forename: Lan-Yan
authors.initials: LY
authors.lastname: Yang
authors.affiliation: Duke Department of Biostatistics and Bioinformatics, Durham, North Carolina.
authors.forename: Shein-Chung
authors.initials: SC
authors.lastname: Chow
authors.affiliation: Birmingham VA Medical Center and University of Alabama.
authors.forename: Victoria
authors.initials: V
authors.lastname: Johnson
authors.affiliation: Duke University Medical Center.
authors.forename: John R
authors.initials: JR
authors.lastname: Guyton
authors.affiliation: Duke Clinical Research Institute ; Duke University Medical Center.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Muir
authors.affiliation: Johns Hopkins University , Baltimore, Maryland.
authors.forename: Mark
authors.initials: M
authors.lastname: Sulkowski
authors.affiliation: University of California San Diego.
authors.forename: Charles
authors.initials: C
authors.lastname: Hicks
keywords: HCV; HCV RNA; HIV; apolipoprotein CIII; apolipoproteins; lipoproteins