title: Robust estimation of group-wise cortical correspondence with an application to macaque and human neuroimaging studies.
abstract: We present a novel group-wise registration method for cortical correspondence for local cortical thickness analysis in human and non-human primate neuroimaging studies. The proposed method is based on our earlier template based registration that estimates a continuous, smooth deformation field via sulcal curve-constrained registration employing spherical harmonic decomposition of the deformation field. This pairwise registration though results in a well-known template selection bias, which we aim to overcome here via a group-wise approach. We propose the use of an unbiased ensemble entropy minimization following the use of the pairwise registration as an initialization. An individual deformation field is then iteratively updated onto the unbiased average. For the optimization, we use metrics specific for cortical correspondence though all of these are straightforwardly extendable to the generic setting: The first focused on optimizing the correspondence of automatically extracted sulcal landmarks and the second on that of sulcal depth property maps. We further propose a robust entropy metric and a hierarchical optimization by employing spherical harmonic basis orthogonality. We also provide the detailed methodological description of both our earlier work and the proposed method with a set of experiments on a population of human and non-human primate subjects. In the experiment, we have shown that our method achieves superior results on consistency through quantitative and visual comparisons as compared to the existing methods.
authors.affiliation: Department of Computer Science, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Ilwoo
authors.initials: I
authors.lastname: Lyu
authors.affiliation: Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Sun H
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Korea University Seoul, South Korea.
authors.forename: Joon-Kyung
authors.initials: JK
authors.lastname: Seong
authors.affiliation: R&D Team, Health and Medical Equipment Business, Samsung Electronics Suwon, South Korea.
authors.forename: Sang W
authors.initials: SW
authors.lastname: Yoo
authors.affiliation: Montreal Neurological Institute, McGill University Montreal, QC, Canada.
authors.forename: Alan
authors.initials: A
authors.lastname: Evans
authors.affiliation: Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Yundi
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Emory university Atlanta, GA, USA.
authors.forename: Mar
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: Department of Computer Science, University of North Carolina Chapel Hill, NC, USA ; Biomedical Research Imaging Center, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Niethammer
authors.affiliation: Department of Computer Science, University of North Carolina Chapel Hill, NC, USA ; Department of Psychiatry, University of North Carolina Chapel Hill, NC, USA.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Styner
keywords: cortical surface; entropy minimization; group-wise registration; spherical harmonics; sulcal curve; surface registration