title: Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits.
abstract: Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Xingxing
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.|b Anhui Engineering Research Center for Chinese Medicine Preparation , Hefei , P.R. China , and.
authors.forename: Shuangying
authors.initials: S
authors.lastname: Gui
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Wu
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Yingji
authors.initials: Y
authors.lastname: Cao
authors.affiliation: a Department of Pharmacy , Anhui University of Chinese Medicine , Hefei , P.R. China.
authors.forename: Dengke
authors.initials: D
authors.lastname: Yin
authors.affiliation: c Global Pharmaceutical Research and Development, Hospira Inc. , McPherson , KS , USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Ma
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D008297:Male; D009019:Morphinans / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism; D009339:Needles; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012995:Solubility
chemical_list: D009019:Morphinans; C009271:sinomenine
keywords: Dissolving microneedle; sinomenine hydrochloride; transdermal drug delivery