title: STRESS IN THE CLASSIFICATION OF PITUITARY TUMORS. FOCUS ON AGGRESSIVE PITUITARY ADENOMAS.
abstract: After a brief summary of the stress concept and the contribution of Dr. Hans Selye, this publication focuses on the classification of pituitary neoplasms and the difficulties to provide conclusive information on the prognosis of various pituitary tumor types. The term "aggressive pituitary tumors" was introduced. These tumors have a rapid cell proliferation rate. At present, the assessment of Ki-67 nuclear labeling index appears to be the simplest and most reliable method to evaluate tumor cell multiplication. Further studies on pituitary tumor biomarkers are needed.
authors.forename: Kálmán
authors.initials: K
authors.lastname: Kovács
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.forename: Eva
authors.initials: E
authors.lastname: Horváth
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000145:classification / Q000175:diagnosis / Q000628:therapy; D000236:Adenoma / Q000737:chemistry / Q000145:classification / Q000175:diagnosis / Q000628:therapy; D014408:Biomarkers, Tumor / Q000032:analysis*; D002170:Canada; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D049673:History, 20th Century; D006801:Humans; D006814:Hungary; D019394:Ki-67 Antigen / Q000032:analysis*; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D009626:Terminology as Topic
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen