title: PPARγ and Its Ligands: Potential Antitumor Agents in the Digestive System.
abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligand-activated nuclear hormone receptor superfamily of transcription factors, with expression in several different cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can suppress the growth of oral, esophageal, gastric, colorectal, liver, biliary, and pancreatic tumor cells, suggesting that PPARγ ligand is a potential anticancer agent in PPARγ-expressing tumors. This review highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in the digestive system.
authors.forename: Linjing
authors.initials: L
authors.lastname: Shu
authors.forename: Renhuan
authors.initials: R
authors.lastname: Huang
authors.forename: Songtao
authors.initials: S
authors.lastname: Wu
authors.forename: Zhaozhao
authors.initials: Z
authors.lastname: Chen
authors.forename: Ke
authors.initials: K
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No. 14., 3rd Sec., Ren Min Nan Road, Chengdu 610041, P. R. China. xcai@scu.edu.cn.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Cai
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism*; D004064:Digestive System / Q000473:pathology*; D004067:Digestive System Neoplasms / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008024:Ligands; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D047495:PPAR gamma; D012333:RNA, Messenger