title: [Impact of spasmolytic on polyp and adenoma detection during colonoscopy: a meta-analysis].
abstract: OBJECTIVE
  To investigate the impact of intestinal spasmolytic on colon polyps and adenoma detection rate during colonoscopy.
  
  
  METHODS
  Literatures related to the effect of intestinal spasmolytic on colon polyp or adenoma detection rate were retrieved from PubMed, Medline, EBSCO, High Wire Press, OVID, EMBASE, and the China National Knowledge Articles, etc. published before July 2014. Unified data were extracted by two researchers independently and organized using Jadad scale to evaluate the quality of the enrolled studies through Review manager 5.2 Meta-analysis software.
  
  
  RESULTS
  Six articles were enrolled with total 47,509 cases, including 16,867 cases in the scopolamine group and 30,642 cases in the placebo group. Meta analysis showed spasmolytic could increase the detective rate of polyps (OR=1.24, 95% CI:1.19-1.30), adenoma (OR=1.25, 95% CI:1.19-1.30) and high-risk adenoma (OR=1.22, 95% CI:1.16-1.29).
  
  
  CONCLUSIONS
  Using colonoscopy spasmolytic scopolamine can increase the detection rate of colonic polyp and adenoma.
authors.affiliation: Department of Gastroenterology,Yangzhou First People's Hospital, Jiangsu Yangzhou 225001, China. chinadybvip@yeah.net.
authors.forename: Songxin
authors.initials: S
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Deng
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Gao
authors.forename: Dacheng
authors.initials: D
authors.lastname: Wu
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000236:Adenoma; D002681:China; D003110:Colonic Neoplasms; D003111:Colonic Polyps; D003113:Colonoscopy; D006801:Humans; D010276:Parasympatholytics
chemical_list: D010276:Parasympatholytics