title: [The role of induced pluripotent stem cells in modeling of neurological diseases].
abstract: The longitudinal follow-up of the development and course of central nervous system related diseases on a molecular level was unsolved for decades. Direct examination of the pathological state on organ or tissue levels was feasible in the late stage of the disease. Modeling diseases has an important role in studying the pathophysiological mechanism underlying central nervous system disorders but animals used as model organism due to species specific nervous system differences can lead to less valid conclusions in translational research. The model of induced pluripotent stem cells may help to solve partially these types of problems. In recent years this model had a strong effect on understanding the pathogenesis of neurodegenerative and neurodevelopmental disorders. Although induced pluripotent stem cells have a low impact on clinical research studies, they have a prominent role in the field of cell physiology and molecular biology research.
authors.affiliation: Szentágothai János Idegtudományi Doktori Iskola, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Vaskapu u. 10-14/B/506., 1097.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Balogh
authors.forename: János
authors.initials: J
authors.lastname: Réthelyi
authors.forename: Mária
authors.initials: M
authors.lastname: Molnár
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D002986:Clinical Trials as Topic; D002658:Developmental Disabilities / Q000601:surgery; D004195:Disease Models, Animal; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D009422:Nervous System Diseases / Q000601:surgery*; D019636:Neurodegenerative Diseases / Q000601:surgery; D015203:Reproducibility of Results; D013045:Species Specificity; D033581:Stem Cell Transplantation; D036302:Therapeutic Human Experimentation; D057170:Translational Research, Biomedical
keywords: central nervous system diseases; induced pluripotent stem cells; indukált pluripotens őssejt; központi idegrendszeri megbetegedések; translational research; transzlációs kutatások