title: Human telomerase inhibitors from microbial source.
abstract: Telomerase enzyme inhibitors have gained attention of scientific field due to the specificity of action of telomerase based therapies. Some telomerase have good combinatorial action with certain DNA damaging drugs. Natural compounds isolated from microbes provide a new scope of screening and large scale production of telomerase inhibitors. This review emphasizes the biochemistry and mode of action of different types of telomerase inhibitors isolated from microbial sources. Also elaborates on classification of telomerase inhibitors based on their mode of action in cancer cells.
authors.affiliation: Cancer Therapeutics Laboratory, Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, India.
authors.forename: Kalarikkal Gopikrishnan
authors.initials: KG
authors.lastname: Kiran
authors.forename: Muthusamy
authors.initials: M
authors.lastname: Palaniswamy
authors.forename: Jayaraman
authors.initials: J
authors.lastname: Angayarkanni
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology*; D005658:Fungi / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D019098:Telomerase / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; C509186:TERT protein, human; D019098:Telomerase