title: From standard to new genome-based therapy of gastric cancer.
abstract: Randomized trials and meta-analyses have established surgery, radiotherapy, chemotherapy and targeted therapy in the multidisciplinary treatment of gastric cancer. However, personalized prediction of both therapeutic resistance and recurrence or metastatic disease progression still remains a researcher's dream. In this editorial, we summarize standard treatment approaches as well as their limitations, with an effort to highlight novel, next-generation sequencing technology-based clinical approaches for gastric cancer treatment.
authors.affiliation: Centre for Biosystems and Genomic Network Medicine, University of Ioannina, Ioannina, Greece.
authors.forename: Georgios D
authors.initials: GD
authors.lastname: Lianos
authors.forename: Alberto
authors.initials: A
authors.lastname: Mangano
authors.forename: William C
authors.initials: WC
authors.lastname: Cho
authors.forename: Dimitrios H
authors.initials: DH
authors.lastname: Roukos
mesh_terms: D019008:Drug Resistance, Neoplasm; D016678:Genome; D006801:Humans; D058990:Molecular Targeted Therapy; D057285:Precision Medicine; D017422:Sequence Analysis, DNA / Q000379:methods*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000628:therapy*
keywords: cancer biomarkers; gastric cancer; genome-based therapy; next-generation sequencing analyses; personalized cancer medicine; whole-exome sequencing; whole-genome sequencing