title: High mortality due to accidental salinomycin intoxication in sheep.
abstract: In February 2012, 100% mortality was reported in a herd with 79 local sheep that were kept around of Abhar, Northwest of Iran. The ration for adult sheep was daily mixed (40 kg straw, 25 kg wheat and 2 kg Vit-C premix) and accidentally 1 500 g of salinomycin (Salinomycin 12% Premix; Aras Bazar Laboratories, Iran) had been added to the ration (22388 mg/kg = 22388 ppm) and overnight was fed to herd. At the morning, 78 sheep were founded dead and one of them showed convulsive seizures. Postmortem examination revealed pulmonary congestion and edema, hemorrhages in abomasum, large pale kidney and white streak lines in myocardium. Main histopathologic lesions were extensive subepicardial and intercardiomyofibers hemorrhages, extensive cardiomyolysis and myocarditis in heart, severe hyperemia and extensive acute tubular necrosis (ATN) in kidneys and focal necrosis and retention of bile cholangitis in the liver. In this study, on the basis of the history, observation of the ionophore remnant in the ration, clinical signs, gross and histopathological findings, acute salinomycin intoxication is definitely diagnosed.
authors.affiliation: Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Ashrafihelan
authors.affiliation: Veterinary Organization, Zanjan, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Eisapour
authors.affiliation: Veterinary Organization, Zanjan, Iran.
authors.forename: Amir Mehdi
authors.initials: AM
authors.lastname: Erfani
authors.affiliation: Veterinary Organization, Zanjan, Iran.
authors.forename: Amir Ali
authors.initials: AA
authors.lastname: Kalantary
authors.affiliation: Toxicology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
authors.forename: Jamileh Salar
authors.initials: JS
authors.lastname: Amoli
authors.affiliation: Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mozafari
keywords: Iran; acute toxicosis; acute tubular necrosis; cardiomyolysis; salinomycin; sheep