title: Neuro-Ophthalmic Syndromes and Processing Speed in Multiple Sclerosis.
abstract: The impact of prior neuro-ophthalmic syndromes on the performance on vision-based neuropsychological tasks in patients with multiple sclerosis (MS) is unknown. Two groups of MS participants, one with (Msos+) and the other without (Msos-), a history of neuro-ophthalmic syndromes, underwent neuropsychological assessment and were compared with healthy age- and education-matched controls (HC). Participants with Msos+ performed significantly worse on the symbol digit modalities test than the Msos- (P < 0.03) and the HC groups (P < 0.01) and coding (P < 0.01). A clinical history of neuro-ophthalmic syndromes is associated with reduced performance on visual processing speed tasks.
authors.affiliation: Neuropsychophysiology Lab-CIPsi (SLC, OFG), University of Minho, Braga, Portugal; Neuropsychology and Neuroscience Research (SLC, NDC, JDL), Kessler Foundation, West Orange, New Jersey; Department of Physical Medicine and Rehabilitation (SLC, OFG, NDC), Rutgers New Jersey Medical School, Newark, New Jersey; Department of Counseling and Applied Educational Psychology(OFG), Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts; Spaulding Neuromodulation Center (OFG), Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts; Department of Neurology (OFG), Rutgers New Jersey Medical School, Newark, New Jersey; Faculty of Psychology and Educational Sciences (JA), University of Coimbra, Coimbra, Portugal; Proaction Laboratory (JA), Faculty of Phycology and Educational Sciences, University of Coimbra, Portugal.
authors.forename: Silvana L
authors.initials: SL
authors.lastname: Costa
authors.forename: Óscar F
authors.initials: ÓF
authors.lastname: Gonçalves
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Chiaravalloti
authors.forename: John
authors.initials: J
authors.lastname: DeLuca
authors.forename: Jorge
authors.initials: J
authors.lastname: Almeida
mesh_terms: D000328:Adult; D001307:Auditory Perception / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D065855:Spatial Processing; D013577:Syndrome; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology*