title: Are Lipases Still Important Biocatalysts? A Study of Scientific Publications and Patents for Technological Forecasting.
abstract: The great potential of lipases is known since 1930 when the work of J. B. S. Haldane was published. After eighty-five years of studies and developments, are lipases still important biocatalysts? For answering this question the present work investigated the technological development of four important industrial sectors where lipases are applied: production of detergent formulations; organic synthesis, focusing on kinetic resolution, production of biodiesel, and production of food and feed products. The analysis was made based on research publications and patent applications, working as scientific and technological indicators, respectively. Their evolution, interaction, the major players of each sector and the main subject matters disclosed in patent documents were discussed. Applying the concept of technology life cycle, S-curves were built by plotting cumulative patent data over time to monitor the attractiveness of each technology for investment. The results lead to a conclusion that the use of lipases as biocatalysts is still a relevant topic for the industrial sector, but developments are still needed for lipase biocatalysis to reach its full potential, which are expected to be achieved within the third, and present, wave of biocatalysis.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
authors.forename: Karina de Godoy
authors.initials: Kde G
authors.lastname: Daiha
authors.affiliation: Unidade de Biologia, Centro Universitário Estadual da Zona Oeste, Rio de Janeiro, Brasil.
authors.forename: Renata
authors.initials: R
authors.lastname: Angeli
authors.affiliation: Agência de Inovação, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
authors.forename: Sabrina Dias
authors.initials: SD
authors.lastname: de Oliveira
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
authors.forename: Rodrigo Volcan
authors.initials: RV
authors.lastname: Almeida
mesh_terms: D000821:Animal Feed; D000818:Animals; D055162:Biocatalysis; D056804:Biofuels; D001709:Biotechnology / Q000639:trends*; D003902:Detergents / Q000138:chemical synthesis / Q000737:chemistry; D019649:Food Industry; D005544:Forecasting; D006801:Humans; D008049:Lipase / Q000737:chemistry*; D010330:Patents as Topic / Q000706:statistics & numerical data; D011642:Publications / Q000706:statistics & numerical data
chemical_list: D056804:Biofuels; D003902:Detergents; D008049:Lipase