title: Association between TNFSF4 tagSNPs and myocardial infarction in a Chinese Han population.
abstract: Tumor necrosis factor superfamily member 4 (TNFSF4) plays an important role in atherosclerosis development. However, the biological significance of TNFSF4 variants on myocardial infarction (MI) pathogenesis remains poorly understood. We investigated the influence of 5 TNFSF4 tagging single nucleotide polymorphisms (rs3861950, rs17346501, rs7518045, rs1234313, and rs3850641) on individual susceptibility to MI in a Chinese population of 285 MI patients and 645 controls. Genotyping was performed using the polymerase chain reaction-ligase detection reaction method. In multivariate logistic regression analysis, only the TNFSF4 tagging single nucleotide polymorphism rs7518045 exhibited a significant effect on MI risk; A allele (odds ratio = 0.68, 95% confidence interval = 0.46-1.00, P = 0.048) and AA genotype (odds ratio = 0.64, 95% confidence interval = 0.42-0.97, P = 0.036) were associated with a decreased risk of MI compared with the G allele and the combined AG/GG genotype, respectively. Moreover, the haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G containing the rs7518045 A allele also exhibited a significant association with a decreased risk for MI (odds ratio = 0.42, 95% confidence interval = 0.21-0.84, P = 0.011). Our study showed that the A allele of the rs7518045 and haplotype rs3861950C-rs17346501C-rs7518045A-rs1234313G in the TNFSF4 gene were associated with decreased MI risk in a Chinese Han population. Further studies using larger sample sizes and in diverse ethnic populations are needed to confirm the general validity of our findings.
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: J
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, Guangdong, China.
authors.forename: J-M
authors.initials: JM
authors.lastname: Cen
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: M-Y
authors.initials: MY
authors.lastname: Cai
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: Z-C
authors.initials: ZC
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, Guangdong, China.
authors.forename: X-L
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, Guangdong, China xiongxingdong@126.com.
authors.forename: X-D
authors.initials: XD
authors.lastname: Xiong
mesh_terms: D000368:Aged; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D053278:OX40 Ligand; C089251:TNFSF4 protein, human