title: Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein.
abstract: The role of angiotensin II in regulating Na+/K(+)-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2*-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.
authors.forename: Sayed Modinur
authors.initials: SM
authors.lastname: Rahaman
authors.forename: Kuntal
authors.initials: K
authors.lastname: Dey
authors.forename: Tapati
authors.initials: T
authors.lastname: Chakraborti
authors.forename: Sajal
authors.initials: S
authors.lastname: Chakraborti
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D005978:Glutathione / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000201:enzymology*; D011651:Pulmonary Artery / Q000166:cytology / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D000804:Angiotensin II; D000254:Sodium-Potassium-Exchanging ATPase; D005978:Glutathione