title: 111In-Pentetreotide SPECT/CT in Pulmonary Carcinoid.
abstract: OBJECTIVE
  We evaluated somatostatin receptor scintigraphy (SRS) with (111)In-pentetreotide incremental value in pulmonary carcinoid (PC) diagnosis compared to contrast enhanced Computed Tomography (ceCT).
  
  
  METHODS
  We enrolled 81 patients with ascertained PC, 39 at initial staging and 42 in follow-up; the primary tumor had already been excised in 68 cases. Single Photon emission Computed Tomography (SPECT) images were reconstructed with the iterative method and fused with non-enhanced Computed tomography (CT) images.
  
  
  RESULTS
  Primary PC or metastatic lesions were ascertained in 55/81 patients and SPECT/CT was positive in 50/55 cases, while ceCT was positive in 44/55. Comparing SPECT/CT with ceCT results, we found a sensitivity of 96 vs. 87.5%, and specificity of 92% vs. 97% for the detection of primary lesion or recurrent disease. A total of 198 lesions were ascertained at SPECT/CT, while 161 at ceCT, with values of sensitivity and specificity of 85.5% and 84.6% for SRS and 75.2% and 90.5% respectively.
  
  
  CONCLUSIONS
  (111)In-Pentetreotide SPECT/CT proved to be more sensitive and accurate than ceCT, thus enhancing its role in evaluating patients with PC.
authors.affiliation: Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy agostino.chiaravalloti@gmail.com.
authors.forename: Agostino
authors.initials: A
authors.lastname: Chiaravalloti
authors.affiliation: Unit of Nuclear Medicine, University of Sassari, Sassari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Spanu
authors.affiliation: Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Danieli
authors.affiliation: Department of Nuclear Medicine, University of Trieste, Trieste, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Dore
authors.affiliation: Unit of Nuclear Medicine, University of Sassari, Sassari, Italy.
authors.forename: Bastiana
authors.initials: B
authors.lastname: Piras
authors.affiliation: Unit of Nuclear Medicine, University of Sassari, Sassari, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Falchi
authors.affiliation: Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Tavolozza
authors.affiliation: Unit of Nuclear Medicine, University of Sassari, Sassari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Madeddu
authors.affiliation: Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy Istituto di Ricerca e Cura a Carattere Schientifico, Neuromed, Pozzilli, Italy.
authors.forename: Orazio
authors.initials: O
authors.lastname: Schillaci
mesh_terms: D000368:Aged; D002276:Carcinoid Tumor / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000378:metabolism; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism; D012680:Sensitivity and Specificity; D013004:Somatostatin / Q000031:analogs & derivatives*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide
keywords: 111In-pentetreotide; NET; SPECT; pulmonary carcinoid; scintigraphy; somatostatin receptors