title: How to treat an extensive form of primary intestinal lymphangiectasia?
abstract: We report a case of a 42-year-old man with a rare disorder known as primary intestinal lymphangiectasia, which is characterized by dilated intestinal lymphatics that lead to the development of protein-losing enteropathy. The patient presented with a grand mal seizure caused by malabsorption-derived electrolytes and a protein disorder. Signs of the disease, including chronic diarrhea and peripheral edema, manifested 10 years ago, but a diagnosis was never made. The diagnosis was suspected because of the clinical manifestations, laboratory tests, imaging and endoscopic findings. Hyperemic and edematous mucosa of the small intestine corresponded to scattered white spots with dilated intestinal lymphatics and whitish villi in the histological specimen of the biopsied jejunal mucosa. Although numerous therapeutic strategies are available, only octreotide therapy proved to be an effective means of therapeutic resolution in this patient. Although the patient had a partial remission following the use of a slow release formula of octreotide, his prognosis, clinical course, and future treatment challenges are yet to be determined.
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Rosana
authors.initials: R
authors.lastname: Troskot
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Jurčić
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Ante
authors.initials: A
authors.lastname: Bilić
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Marija
authors.initials: M
authors.lastname: Gomerčić Palčić
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Stanko
authors.initials: S
authors.lastname: Težak
authors.affiliation: Rosana Troskot, Dragan Jurčić, Ante Bilić, Faculty of Medicine, J. J. Strossmayer University of Osijek, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Clinical Hospital "Sveti Duh", 10000 Zagreb, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Brajković
mesh_terms: D000328:Adult; D001706:Biopsy; D058582:Double-Balloon Enteroscopy; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008201:Lymphangiectasis, Intestinal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008209:Lymphedema / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D015282:Octreotide
keywords: Diet; Malabsorption; Octreotide; Primary intestinal lymphangiectasia; Seizure; Treatment