title: Hodgkin's lymphoma in an adolescent previously treated with surgical resection of third ventricular juvenile pilocytic astrocytoma.
abstract: We present a case of a 19-year-old man with cervical lymphadenopathy diagnosed with classical Hodgkin's lymphoma 9 years after gross total resection of a third ventricular juvenile pilocytic astrocytoma (JPA). Chemotherapy or radiation therapy was not a part of his initial JPA treatment. Owing to his two primary neoplasms, genetic testing was performed, which revealed heterozygous polymorphisms of unknown significance for CDH1 and p53, and negative BRAF mutation analysis. Our case reports development of classical Hodgkin's lymphoma after JPA in the absence of antecedent radiation and/or chemotherapy, and identifiable genetic predisposition.
authors.affiliation: Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.
authors.forename: Dillon Y
authors.initials: DY
authors.lastname: Chen
authors.affiliation: Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.
authors.forename: John Ross
authors.initials: JR
authors.lastname: Crawford
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000235:genetics / Q000601:surgery; D001932:Brain Neoplasms / Q000235:genetics / Q000601:surgery; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D055815:Young Adult