title: Nuclear β-Catenin under Control.
abstract: During Wnt stimulation, β-catenin accumulates in the nucleus, where it regulates gene transcription. In this issue of Developmental Cell, Lu et al. (2015) report a mechanism that specifically targets this nuclear pool for degradation, using lysine demethylation as ubiquitination signal.
authors.affiliation: Department of Biology, McGill University, Montreal H3A1B1, Quebec, Canada. Electronic address: francois.fagotto@mcgill.ca.
authors.forename: François
authors.initials: F
authors.lastname: Fagotto
mesh_terms: D000818:Animals; D044783:F-Box Proteins / Q000378:metabolism*; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D044783:F-Box Proteins; D051176:beta Catenin; D056484:Jumonji Domain-Containing Histone Demethylases