title: P53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility.
abstract: BACKGROUND
  Tumor suppressor gene p53 plays an important role in the maintenance of the genomic integrity, and mutation in the gene may alter an individual's susceptibility to various carcinomas. P53 Arg72Pro or codon 72 polymorphism has been indicated to increase the risk of developing certain cancers such as bladder cancer and cervical cancer. Human papillomavirus (HPV) infection has been shown as a risk factor for certain cancers such as cervical cancer and oral cancer as well, and the HPV oncoprotein E6 may induce the degradation of p53 function. However, the association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection remains inconclusive. Therefore, this meta-analysis involving 5,614 participants was performed to investigate the relations among the p53 Arg72Pro polymorphism, HPV infection, and the risk of developing oral cancer.
  
  
  RESULTS
  A search of the literature by PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases was conducted to identify studies based on the inclusion and exclusion criteria. Odds ratios with 95% confidence intervals were combined using a random-effect model or a fixed-effect model. The current study was conducted with 13 studies consisting of 2,413 cases and 3,201 controls. Neither overall analysis nor stratified analyses detected any obvious evidence of association between p53 Arg72Pro polymorphism and oral cancer susceptibility in all genetic models. However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.
  
  
  CONCLUSIONS
  In the current meta-analysis which used the quantitative data synthesis for the first time, our study demonstrated that p53 Arg72Pro polymorphism together with HPV infection might jointly alter an individual's susceptibility to the risk of oral cancer. Our results suggested that p53 Arg72Pro polymorphism may partly contribute to the pathogenesis of oral cancer development.
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230032, China. houjun@ahmu.edu.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY, 11794, USA. ying.gu@stonybrook.edu.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA. wei.hou@stonybrookmedicine.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.affiliation: Department of Applied Mathematics Statistics, College of Engineering and Applied Sciences, Stony Brook University, Stony Brook, NY, 11794, USA. song.wu@stonybrook.edu.
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Orthopaedic Surgery, the Second Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230601, China. dscao1966@126.com.
authors.forename: Yin
authors.initials: Y
authors.lastname: Lou
authors.affiliation: Department of Stomatology, the Second Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 23061, China. ywyu8001@163.com.
authors.forename: Wenyu
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230032, China. 18756987937@163.com.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230032, China. ykhu992@yahoo.com.
authors.forename: Yukun
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230032, China. sunming1124@163.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.affiliation: Department of Stomatology, the First Affiliated Hospital of the Anhui Medical University, Hefei, Anhui, 230032, China. xuehaowei@ahmu.edu.cn.
authors.forename: Haowei
authors.initials: H
authors.lastname: Xue
mesh_terms: D003062:Codon; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000150:complications* / Q000821:virology; D020641:Polymorphism, Single Nucleotide; D011159:Population Surveillance; D017594:Publication Bias; D012306:Risk; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53