title: Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader-Willi Syndrome (PWS).
abstract: We tested the hypothesis that patients with Prader-Willi syndrome (PWS) may be at lower risk of developing non-alcoholic fatty liver disease (NAFLD) because of a higher insulin sensitivity. Twenty-one PWS patients and 42 control subjects closely similar for age, gender, pubertal stage and body mass index (CNT), were studied. Metabolic profile and body composition were assessed. NAFLD was established by a validated method of US grading (range from G0 to G3). PWS patients showed a significantly better metabolic profile (lower waist circumference, fasting glucose levels, HOMA-IR, cholesterol, transaminase levels and trunk fat mass/fat mass ratio). Furthermore, NAFLD G1stage was significantly more frequent in PWS subjects (P < 0.05), whereas G2 stage was significantly more frequent in control patients (P < 0.05). NAFLD grading seems to correlate with body composition in PWS, also after adjustment for sex and GH treatment. To our knowledge, this is the first report suggesting a reduced risk of NAFLD in PWS children.
authors.affiliation: Autoimmune Endocrine Diseases Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Fintini
authors.affiliation: Endocrinology and Diabetic Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.|D.P.U.O. 'Bambino Gesù' Children's Hospital, 'Tor Vergata' University, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Inzaghi
authors.affiliation: Radiology Dept., Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colajacomo
authors.affiliation: Autoimmune Endocrine Diseases Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bocchini
authors.affiliation: Italian Auxological Institute Foundation, Piancavallo, Verbania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Grugni
authors.affiliation: Endocrinology and Diabetic Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Brufani
authors.affiliation: Endocrinology and Diabetic Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cappa
authors.affiliation: Hepato-Metabolic Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Nobili
authors.affiliation: D.P.U.O. 'Bambino Gesù' Children's Hospital, 'Tor Vergata' University, Rome, Italy.|Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Cianfarani
authors.affiliation: Autoimmune Endocrine Diseases Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Crinò
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000453:epidemiology*; D011218:Prader-Willi Syndrome / Q000503:physiopathology*; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D013006:Growth Hormone; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: NAFLD; Prader-Willi; obesity; paediatric