title: Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies.
abstract: Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Kyu-Sun
authors.initials: KS
authors.lastname: Choi
authors.affiliation: Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Hyoung-Joon
authors.initials: HJ
authors.lastname: Chun
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Hyeong-Joong
authors.initials: HJ
authors.lastname: Yi
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Jin-Hwan
authors.initials: JH
authors.lastname: Cheong
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Choong-Hyun
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Suck-Jun
authors.initials: SJ
authors.lastname: Oh
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Yong
authors.initials: Y
authors.lastname: Ko
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Koang-Hum
authors.initials: KH
authors.lastname: Bak
authors.affiliation: Department of Neurosurgery, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Je-Il
authors.initials: JI
authors.lastname: Ryu
authors.affiliation: Department of Emergency Medicine, College of Medicine, Hallym University, Seoul, Korea.
authors.forename: Wonhee
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Emergency Medicine, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Taeho
authors.initials: T
authors.lastname: Lim
authors.affiliation: Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Hyeong Sik
authors.initials: HS
authors.lastname: Ahn
authors.affiliation: 1] Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea [2] Department of Literary Arts, Brown University, Rhode Island, USA.
authors.forename: Il Min
authors.initials: IM
authors.lastname: Ahn
authors.affiliation: Department of Nursing Science, College of Nursing, Gachon University, Incheon, Korea.
authors.forename: Seon-Heui
authors.initials: SH
authors.lastname: Lee
mesh_terms: D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D064887:Observational Studies as Topic; D016017:Odds Ratio; D011379:Prognosis; D020521:Stroke / Q000097:blood* / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D006020:Glycopeptides; C048197:copeptins