title: Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is the fifth most prevalent cancer and is one of the leading causes of cancer-related death. The risk factors for HCC include cirrhosis, chronic viral hepatitis, heavy alcohol intake and metabolic diseases such as obesity, type 2 diabetes and metabolic syndrome. Insulin resistance is a common denominator of all of these conditions and is tethered to hyperinsulinaemia. Here, we give an overview of the recent advances linking hyperinsulinaemia to HCC development and progression. In particular, we summarise the underlying causes of hyperinsulinaemia in the setting of chronic liver diseases. We present epidemiological evidence linking metabolic diseases to HCC risk and HCC-related mortality, as well as the pathogenic cellular and molecular mechanisms explaining this relation. A better understanding of the mechanisms by which insulin participates in HCC biology might ultimately provide novel opportunities for prevention and treatment.
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.
authors.forename: Hamza
authors.initials: H
authors.lastname: Chettouh
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|Service d'Hépatologie, AP-HP, Hôpital Saint-Antoine, Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Lequoy
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|Service d'Hépatologie, AP-HP, Hôpital Saint-Antoine, Paris, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Fartoux
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|Laboratoire Commun de Biologie et Génétique Moléculaires AP-HP, Hôpital Saint-Antoine, Paris, France.|ICAN, Institute of Cardiometabolism and Nutrition, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Vigouroux
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.|INSERM, UMR_S 938, Centre de Recherche Saint-Antoine, Paris, France.
authors.forename: Christèle
authors.initials: C
authors.lastname: Desbois-Mouthon
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004195:Disease Models, Animal; D018450:Disease Progression; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism* / Q000473:pathology; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D008103:Liver Cirrhosis / Q000150:complications; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D024821:Metabolic Syndrome / Q000150:complications; D051379:Mice; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications; D009765:Obesity / Q000150:complications; D051381:Rats; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D007328:Insulin
keywords: hepatocellular carcinoma; insulin resistance; insulin signalling