title: Complete genome sequence of Lactobacillus salivarius Ren, a probiotic strain with anti-tumor activity.
abstract: Lactobacillus salivarius Ren (LsR) (CGMCC No. 3606) is a probiotic strain that was isolated from the feces of a healthy centenarian living in Bama, Guangxi, China. Previous studies have shown that this strain decreases 4-nitroquinoline 1-oxide (4-NQO)-induced genotoxicity in vitro. It also suppresses 4-NQO-induced oral carcinogenesis and 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis, and therefore may be used as an adjuvant therapeutic agent for cancer. Here, we report the complete genome sequence of LsR that consists of a circular chromosome of 1751,565 bp and two plasmids (pR1, 176,951 bp; pR2, 49,848 bp).
authors.affiliation: The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China. Electronic address: erna_sun@163.com.
authors.forename: Erna
authors.initials: E
authors.lastname: Sun
authors.affiliation: The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: renfazheng@263.net.
authors.forename: Fazheng
authors.initials: F
authors.lastname: Ren
authors.affiliation: Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China. Electronic address: 876910384@qq.com.
authors.forename: Songling
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: 494676448@qq.com.
authors.forename: Shaoyang
authors.initials: S
authors.lastname: Ge
authors.affiliation: Beijing Higher Institution Engineering Research Center of Animal Product, Beijing 100083, China. Electronic address: 36103805@qq.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Functional Dairy, China Agricultural University, Beijing 100083, China. Electronic address: 5133323@qq.com.
authors.forename: Huiyuan
authors.initials: H
authors.lastname: Guo
authors.affiliation: Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: lujiang_edu@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Jiang
authors.affiliation: The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: 80773680@qq.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: The Innovation Centre of Food Nutrition and Human Health (Beijing), China Agricultural University, Beijing 100083, China; Beijing Laboratory for Food Quality and Safety, China Agricultural University, Beijing 100083, China. Electronic address: lzhao@cau.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000494:pharmacology; D001482:Base Composition; D002681:China; D005243:Feces / Q000382:microbiology; D059646:Genome Size; D016680:Genome, Bacterial; D006801:Humans; D007778:Lactobacillus / Q000235:genetics*; D008969:Molecular Sequence Data; D019936:Probiotics; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D001426:Bacterial Proteins
keywords: Cancer inhibition; Genome; Genotoxicity; Lactobacillus salivarius Ren; Single molecule real-time sequencing