title: Intracellular delivery cellulose-based bionanogels with dual temperature/pH-response for cancer therapy.
abstract: Polysaccharide-based crosslinked nanogles (bionanogels) exhibiting multiple stimuli-responsive release of encapsulated therapeutics hold a great potential as tumor-targeting intracelluar durg delivery nanocarriers. Herein, we report the synthesis of monodisperse dual temperature/acidic pH-responsive bionanogels (DuR-BNGs) by aqueous crosslinking polymerization through temperature-induced self-association method. The DuR-BNGs have prolonged colloidal stability and negligible non-specific interactions with proteins. In response to acidic pH at higher temperature (above lower critical solution temperature), they exhibit synergistic release of anticancer drugs as a consequence of both acidic pH-sensitivity of carboxymethyl cellulose and temperature-induced volume change of grafted thermoresponsive copolymers. In vitro cell culture results suggest that new colloidally-stable DuR-BNG is a promising candidate promoting dual stimuli-responsive drug release for cancer therapy.
authors.affiliation: Department of Chemistry and Biochemistry, Centre for NanoScience Research, Concordia University, Montreal, Quebec H4B 1R6, Canada.
authors.forename: Yifen
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Department of Chemistry and Biochemistry, Centre for NanoScience Research, Concordia University, Montreal, Quebec H4B 1R6, Canada. Electronic address: john.oh@concordia.ca.
authors.forename: Jung Kwon
authors.initials: JK
authors.lastname: Oh
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures; D009369:Neoplasms / Q000628:therapy*; D058105:Polymerization; D013696:Temperature
chemical_list: D003102:Colloids; D002482:Cellulose
keywords: Bionanogels; Cancer therapy; Dual stimuli-response; Enhanced release; Intracellular drug delivery; Polysaccharide