title: Cardiovascular safety risk assessment for new candidate drugs from functional and pathological data: Conference report.
abstract: This is a report on a 2-day joint meeting between the British Society of Toxicological Pathology (BSTP) and the Safety Pharmacology Society (SPS) held in the UK in November 2013. Drug induced adverse effects on the cardiovascular system are associated with the attrition of more marketed and candidate drugs than any other safety issue. The objectives of this meeting were to foster inter-disciplinary approaches to address cardiovascular risk assessment, improve understanding of the respective disciplines, and increase awareness of new technologies. These aims were achieved. This well attended meeting covered both 'purely functional' cardiovascular adverse effects of drugs (e.g., electrophysiological and haemodynamic changes) as well as adverse effects encompassing both functional and pathological changes. Most of the presentations focused on nonclinical safety data, with information on translation to human where known. To reflect the content of the presentations we have cited key references and review articles.
authors.affiliation: Drug Safety & Metabolism, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom.
authors.forename: Stephanie K
authors.initials: SK
authors.lastname: Klein
authors.affiliation: Drug Safety & Metabolism, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom. Electronic address: will.redfern@astrazeneca.com.
authors.forename: Will S
authors.initials: WS
authors.lastname: Redfern
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D066126:Cardiotoxicity; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000175:diagnosis; D002319:Cardiovascular System / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods*; D004345:Drug Industry / Q000379:methods*; D015507:Drugs, Investigational / Q000009:adverse effects*; D006801:Humans; D018570:Risk Assessment; D006113:United Kingdom
chemical_list: D015415:Biomarkers; D015507:Drugs, Investigational
keywords: Atherosclerosis; Biomarkers; Blood clotting; Cardiac pathology; Cardiooncology; Cardiovascular safety; Imaging; Inotropy; Minimally invasive blood pressure; QT prolongation; Valvulopathy; Vascular pathology