title: Bioactive Diterpenoids from the Leaves of Callicarpa macrophylla.
abstract: A phytochemical investigation of the leaves of Callicarpa macrophylla led to the isolation of five new diterpenoids (1-5), macrophypenes A-E, and nine known analogues (6-14). The structures of 1-5 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray diffraction data, and experimental and calculated electronic circular dichroism spectra. Compound 1 is a spiroditerpenoid with a novel skeleton, and compound 5 is a rare ent-abietane diterpenoid possessing a peroxide bridge. Compounds 1, 5-7, and 11-14 stimulate nerve growth factor mediated neurite outgrowth from PC12 cells.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yihang
authors.initials: Y
authors.lastname: Sun
authors.forename: Meicheng
authors.initials: M
authors.lastname: Wang
authors.forename: Quanhui
authors.initials: Q
authors.lastname: Ren
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Xiaocong
authors.initials: X
authors.lastname: Sun
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Hongwei
authors.initials: H
authors.lastname: Sun
authors.affiliation: ∥Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D032408:Callicarpa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats
chemical_list: D004224:Diterpenes