title: Progress in the research of GPIIb/IIIa antagonists.
abstract: This review covers the recent advances in the development of small RGD (Arg-Gly-Asp sequence) containing peptides and their mimetics as potential antithrombotic agents. Glycoprotein IIb/IIIa (GPIIb/IIIa) antagonists include monoclonal antibodies, RGD peptides, peptide hybrids and nonpeptide mimetics. The current trend in the development of nonpeptide mimetics is clearly directed toward orally active and safe antithrombotic drug candidates. But several nonpeptide mimetics, being evaluated for their oral activity in human clinical trials, are currently not approved for clinical use due to poor safety profile. It is expected that newer and more effective nonpeptide mimetics will be developed in the near future.
authors.affiliation: Jiangsu key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Zhouling
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Jiangsu key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Cao
authors.affiliation: Jiangsu key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Feng
authors.affiliation: Jiangsu key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Jiangsu key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000378:metabolism; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors* / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D000911:Antibodies, Monoclonal; D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex