title: Comparative Evaluation of Sustained Release Collagen Device Containing 5% Metronidazole (Metrogene) along With and Without Scaling and Root Planing at Regular Intervals with Treatment of Chronic Periodontitis: A Case Control Study.
abstract: BACKGROUND
  A short-term study was undertaken with an objective to demonstrate the therapeutic benefit resulting from the use of Metronidazole sponges combined with and without mechanical debridement to mechanical treatment alone in the treatment of periodontal pockets in chronic periodontitis.
  
  
  METHODS
  The study compared the plaque index, gingival index, sulcus bleeding index and probing pocket depth in twenty control sites that received superficial scaling and root planing without the local drug delivery with experimental site A (20 sites that received local drug delivery (5% metronidazole) without superficial scaling and root planing) and experimental site B (20 sites received superficial scaling, root planing and local drug delivery (5% metronidazole) at "0" day, 15(th) day and 30(th) day.
  
  
  RESULTS
  There was a significant reduction in plaque index, gingival index, sulcus bleeding index and probing pocket depth in both experimental sites A and B at different intervals from the baseline.
  
  
  CONCLUSIONS
  From the above conclusions, it can be suggested that a single subgingival application of 5% metronidazole in a collagen carrier can be effective, when associated with debridement in the treatment of adult periodontitis.
authors.affiliation: Professor, Department of Clinical Periodontology and Oral Implantology, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: Tony P
authors.initials: TP
authors.lastname: Paul
authors.affiliation: Professor, Department of Clinical Periodontology and Oral Implantology, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: Rishi
authors.initials: R
authors.lastname: Emmatty
authors.affiliation: Reader, Department of Clinical Periodontology and Oral Implantology, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Pulikkottil
authors.affiliation: Senior Lecturer, Department of Clinical Periodontology and Oral Implantology, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: Aslam Abdul
authors.initials: AA
authors.lastname: Rahman
authors.affiliation: Senior Lecturer, Department of Community and Preventive Dentistry, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: S Arun
authors.initials: SA
authors.lastname: Kumar
authors.affiliation: Postgraduate Student, Department of Clinical Periodontology and Oral Implantology, Royal Dental College, Palakkad, Chalissery, Kerala, India.
authors.forename: Neethu
authors.initials: N
authors.lastname: George
keywords: Chronic periodontitis; collagen; drug delivery system; metronidazole; periodontal pocket