title: Effect of preemptive analgesia with intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor.
abstract: OBJECTIVE
  To evaluate the efficacy of preemptive intravenous oxycodone in the patients undergoing laparoscopic resection of ovarian tumor.
  
  
  METHODS
  Sixty ASA I or II patients undergoing elective laparoscopic resection of ovarian tumor were randomly allocated to one of two groups: Group O (n=30) received intravenous oxycodone (0.1 mg·kg(-1)) 10 minutes before surgery over 2 minutes, and Group N (n=30) received an equivalent volume of normal saline. All patients received a standardized general anesthesia. MBP and HR at the time of arrival of the operating room (T1), 5 min before pneumoperitoneum (T2), 5 minutes (T3), 10 minutes (T4), and 15 minutes after pneumoperitoneum (T5), and VAS scores at postoperative 2, 4, 8, 12 and 24 hour were recorded. The tramadol consumption and side effects in 24 h after surgery were recorded.
  
  
  RESULTS
  VAS pain scores at 2, 4, 8 and 12 hour after operation were significantly lower in Group O (P<0.05). MBP and HR increased significantly due to pneumoperitoneum at T3, T4 and T5, compared with T1 and T2 within Group N, and were higher at T3, T4 and T5 in Group N than at the same time points in Group O. Tramadol consumption was statistically lower in Group O (P=0.0003).
  
  
  CONCLUSIONS
  Preemptive intravenous oxycodone was an efficient and safe method to reduce intraoperative haemodynamic effect and postoperative pain.
authors.affiliation: Na Wang, Department of Anesthesiology, The First Hospital of Jilin University, Jilin, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Yuantao Wang, Department of Urology, The First Hospital of Jilin University, Jilin, China.
authors.forename: Yuantao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Lei Pang, Department of Anesthesiology, The First Hospital of Jilin University, Jilin, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Pang
authors.affiliation: Jinguo Wang, Department of Urology, The First Hospital of Jilin University, Jilin, China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Wang
keywords: Laparoscopy; Oxycodone; Pneumoperitoneum; Postoperative pain; Preemptive analgesia