title: Collision of Ductal Carcinoma In Situ of Anogenital Mammary-like Glands and Vulvar Sarcomatoid Squamous Cell Carcinoma.
abstract: A spectrum of invasive adenocarcinomas presumably arising from the anogenital mammary-like glands of the vulva has been reported. Even rarer are the cases of pure ductal carcinoma in situ that originated from these unique glandular structures. Herein, we report an 81-yr-old woman presented with an invasive well-differentiated squamous cell carcinoma of the vulva. Unexpectedly, the underlying dermis demonstrated a cystically dilated structure that displayed a layer of malignant squamous cells in the periphery, and a second centrally located population of neoplastic cells exhibiting glandular differentiation. In addition, a spindle and pleomorphic malignant cell population consistent with a sarcomatoid carcinoma was identified around the cystic structure. Scattered benign anogenital mammary-like glands were present in the adjacent dermis. The histologic and immunohistochemical findings were consistent with those of vulvar squamous cell carcinoma that has undergone sarcomatoid transformation after spreading in a pagetoid fashion into an underlying focus of ductal carcinoma in situ of anogenital mammary-like gland origin.
authors.affiliation: Department of Pathology (T.A.N.T.), Florida Orlando Hospital, Orlando, Florida Department of Pathology & Genomic Medicine (M.T.D.) Department of Pathology (A.M.), The University of Texas MD Anderson Cancer Center, Houston, Texas Department of Pathology (J.A.C.), Albany Medical College, Albany, New York.
authors.forename: Tien A N
authors.initials: TA
authors.lastname: Tran
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Carlson
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
mesh_terms: D000369:Aged, 80 and over; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002296:Carcinosarcoma / Q000473:pathology; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D005088:Exocrine Glands / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D042361:Mammary Glands, Human; D009362:Neoplasm Metastasis / Q000532:radiotherapy; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010145:Paget Disease, Extramammary / Q000473:pathology; D014844:Vulva / Q000473:pathology*; D007724:Vulvar Lichen Sclerosus / Q000150:complications / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery