title: Absent cavum septum pellucidum: a review with emphasis on associated commissural abnormalities.
abstract: The cavum septum pellucidum (CSP) is an important fetal midline forebrain landmark, and its absence often signifies additional underlying malformations. Frequently detected by prenatal sonography, absence of the CSP requires further imaging with pre- or postnatal MRI to characterize the accompanying abnormalities. This article reviews the developmental anatomy of the CSP and the pivotal role of commissurization in normal development. An understanding of the patterns of commissural abnormalities associated with absence of the CSP can lead to improved characterization of the underlying spectrum of pathology.
authors.affiliation: Department of Radiology, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA, 98105, USA, dinkuaiims@gmail.com.
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Sundarakumar
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Farley
authors.forename: Crysela M
authors.initials: CM
authors.lastname: Smith
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Maravilla
authors.forename: Manjiri K
authors.initials: MK
authors.lastname: Dighe
authors.forename: Jason N
authors.initials: JN
authors.lastname: Nixon
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology*; D016216:Ultrasonography, Prenatal