title: Viral Load in Infants Hospitalized for Respiratory Syncytial Virus Bronchiolitis Correlates with Recurrent Wheezing at Thirty-Six-Month Follow-Up.
abstract: The relationship between viral infection, host immune response in infants with respiratory syncytial virus (RSV) bronchiolitis and subsequent wheezing is discussed. We measured RSV-RNA load and interferon-λ1-3 expression in the nasopharyngeal washings from 68 infants hospitalized for RSV bronchiolitis, and wheezing was assessed 36 months after the first episode of bronchiolitis. Higher RSV-RNA load and higher interferon-λ2/3 levels were found in children with recurrent wheezing at 36-month follow-up.
authors.affiliation: From the *Department of Paediatrics and †Virology Laboratory, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Nenna
authors.forename: Marianna
authors.initials: M
authors.lastname: Ferrara
authors.forename: Ambra
authors.initials: A
authors.lastname: Nicolai
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pierangeli
authors.forename: Carolina
authors.initials: C
authors.lastname: Scagnolari
authors.forename: Paola
authors.initials: P
authors.lastname: Papoff
authors.forename: Guido
authors.initials: G
authors.lastname: Antonelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Moretti
authors.forename: Fabio
authors.initials: F
authors.lastname: Midulla
mesh_terms: D001990:Bronchiolitis, Viral / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007371:Interferon-gamma / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D008297:Male; D012135:Respiratory Sounds / Q000503:physiopathology*; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human; D012189:Retrospective Studies; D019562:Viral Load
chemical_list: D007371:Interferon-gamma