title: Fanconi syndrome due to prolonged use of low-dose adefovir.
abstract: Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a low dosage. We report two cases of Fanconi syndrome induced by ADV at 10 mg/day to call for regular screening for evidence of proximal tubular dysfunction and detailed bone metabolic investigations for prompt detection of ADV nephrotoxicity is critically important to ensure timely drug withdrawal before the development of irreversible tubulointerstitial injury.
authors.affiliation: Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Zhu
authors.affiliation: Department of Pneumology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Huang
authors.affiliation: Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Ye
authors.affiliation: Department of Pneumology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
authors.forename: Liang-Xing
authors.initials: LX
authors.lastname: Wang
keywords: Adefovir; Fanconi syndrome; hypophosphatemia; nephrotoxicity