title: One year in review 2015: systemic lupus erythematosus.
abstract: Systemic lupus erythematosus is a multiorgan autoimmune disease with a highly variable clinical course, typically involving women in childbearing age. At present, many aspects of its pathogenesis still remain unclear. Moreover, although a significant increase of patient survival has been observed in the last decades, morbidity and mortality remain high. Finally, SLE impacts negatively on the health-related quality-of-life of patients. Therefore, multiple aspects of SLE still remain challenging and it continues to be the object of both clinical and translational clinical research. Herewith, we provide a critical digest of the recent literature on this topic.
authors.affiliation: Department of Rheumatology, University of Perugia, Perugia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Mirabelli
authors.affiliation: Department of Rheumatology, University of Perugia, Perugia, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cannarile
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Bruni
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Vagelli
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: De Luca
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Genetic, Oncology and Clinical Medicine (GenOMeC) PhD, University of Siena, Italy.
authors.forename: Linda
authors.initials: L
authors.lastname: Carli
mesh_terms: D000818:Animals; D017281:Cost of Illness; D018450:Disease Progression; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D011237:Predictive Value of Tests; D011788:Quality of Life; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents