title: Ophthalmic and Glaucoma Treatment Characteristics Associated With Changes in Health-related Quality of Life Before and After Newly Diagnosed Primary Open-angle Glaucoma in Nurses' Health Study Participants.
abstract: OBJECTIVE
  To identify attributes related to glaucoma diagnosis or early glaucoma treatment patterns that are associated with changes in health-related quality of life among those with newly diagnosed primary open-angle glaucoma.
  
  
  METHODS
  Among Nurses' Health Study participants with incident medical record-confirmed primary open-angle glaucoma diagnosed in 1992 to 2000, we included 317 women who completed the Short Form-36 Health Survey prediagnosis and postdiagnosis. The 2 primary outcomes were 4-year changes (1992 to 1996 or 1996 to 2000) in the physical and mental component summary scores. Multiple regression models were used to estimate differences in score changes by early treatment pattern history and characteristics as of diagnosis (ie, number of eyes affected, history of cataract, macular degeneration, cup-to-disc ratio, intraocular pressure, visual field loss type).
  
  
  RESULTS
  In multivariable models, no ophthalmologic characteristics were associated with physical component score change. However, compared with treatment with eye drops or pills only, laser trabeculoplasty treatment (concomitant with history of treatment with eye drops or pills in 84%) was associated with a worse mental component score change over 4 years (-2.5 units; 95% confidence interval: -4.6, -0.3); this association was stronger with a family history of glaucoma (P-interaction=0.04) or with bilateral disease (P-interaction=0.001).
  
  
  CONCLUSIONS
  Among patients with incident glaucoma, no major factors were associated with change in physical well being. However, compared with medical treatment only, a history of laser trabeculoplasty, which was commonly accompanied with a history of medical treatment and likely represented the need for a second line of treatment, was associated with a worse decline in mental well being.
authors.affiliation: *Columbia University College of Physicians & Surgeons, New York, NY †Harvard School of Public Health ‡Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital §Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, MA.
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Bailey
authors.forename: Olivia I
authors.initials: OI
authors.lastname: Okereke
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawachi
authors.forename: George A
authors.initials: GA
authors.lastname: Cioffi
authors.forename: Louis R
authors.initials: LR
authors.lastname: Pasquale
authors.forename: Jae H
authors.initials: JH
authors.lastname: Kang
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D042241:Early Diagnosis; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D006304:Health Status; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D053685:Laser Therapy; D008875:Middle Aged; D009726:Nurses / Q000523:psychology*; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000601:surgery; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents