title: Stereoselective Alkylation of (S)-N-Acyl-4-isopropyl-1,3-thiazolidine-2-thiones Catalyzed by (Me3P)2NiCl2.
abstract: The structurally simple (Me3P)2NiCl2 complex catalyzes SN1-type alkylations of chiral N-acyl thiazolidinethiones with diarylmethyl methyl ethers and other stable carbenium cations. The former can contain a variety of functional groups and heteroatoms at the α-position. The resultant adducts are isolated as single diastereomers in high yields and can be converted into enantiomerically pure derivatives in a straightforward manner.
authors.affiliation: †Departament de Química Orgànica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Fernández-Valparís
authors.affiliation: †Departament de Química Orgànica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Romo
authors.affiliation: †Departament de Química Orgànica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Romea
authors.affiliation: †Departament de Química Orgànica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
authors.forename: Fèlix
authors.initials: F
authors.lastname: Urpí
authors.affiliation: †Departament de Química Orgànica and Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Carrer Martí i Franqués 1-11, 08028 Barcelona, Catalonia, Spain.
authors.forename: Hubert
authors.initials: H
authors.lastname: Kowalski
authors.affiliation: ‡Unitat de Difracció de RX. CCiTUB. Universitat de Barcelona, Carrer Solé i Sabarís 1-3, 08028 Barcelona, Catalonia, Spain.
authors.forename: Mercè
authors.initials: M
authors.lastname: Font-Bardia