title: Placental growth factor and placental protein 13 in patients with Balkan endemic nephropathy, a worldwide disease.
abstract: BACKGROUND
  Balkan endemic nephropathy (BEN) is a chronic tubulointerstitial kidney disease occurring in people living in along the tributaries of the Danube River. The aim of the study was to determine serum level and urinary excretion of placental growth factor (PlGF) and placental protein 13 (PP13) in patients with BEN.
  
  
  METHODS
  Thirty patients with BEN from the South Morava River region of Serbia and 18 controls were studied. Age of patients was 74 yr (53-87) and 73 yr (66-83) in controls.
  
  
  RESULTS
  In patients with BEN, serum creatinine was significantly higher than in controls (129.7 vs. 83.2 µmol/L, respectively), but GFR was lower in patients than in controls (40.7 vs. 54.6 mL/min). Serum PlGF was significantly higher in BEN patients than in controls (9.90 vs. 6.80 pg/mL), urinary excretion being significantly lower in patients (0.20 vs. 0.90 pg/mmol creat.). Serum PP13 was significantly lower in BEN patients (208.2 vs. 291.0 pg/mL). Urinary excretion of PP13 was also significantly lower in BEN patients than in controls (32.5 vs. 182.5 pg/mmol creat). In multivariate regression analysis BEN, sex and age were significant determinants of the observed changes in PlGF and PP13.
  
  
  CONCLUSIONS
  Important changes of PlGF and PP13 in patients with BEN were demonstrated, where kidney disease, female sex, and the age have been significant determinants.
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.|b Department of Biomedical Sciences , State University of Novi Pazar , Novi Pazar , Serbia.
authors.forename: Vladisav
authors.initials: V
authors.lastname: Stefanovic
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.
authors.forename: Rade
authors.initials: R
authors.lastname: Cukuranovic
authors.affiliation: b Department of Biomedical Sciences , State University of Novi Pazar , Novi Pazar , Serbia.
authors.forename: Zana
authors.initials: Z
authors.lastname: Dolicanin
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.
authors.forename: Jovana
authors.initials: J
authors.lastname: Cukuranovic
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.
authors.forename: Slavica
authors.initials: S
authors.lastname: Stojnev
authors.affiliation: b Department of Biomedical Sciences , State University of Novi Pazar , Novi Pazar , Serbia.
authors.forename: Dragan
authors.initials: D
authors.lastname: Bogdanovic
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.
authors.forename: Milena
authors.initials: M
authors.lastname: Rajic
authors.affiliation: a Faculty of Medicine , University of Nis , Nis , Serbia and.
authors.forename: Gordana
authors.initials: G
authors.lastname: Kocic
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001449:Balkan Nephropathy / Q000097:blood* / Q000453:epidemiology; D015415:Biomarkers; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood*; D005260:Female; D037161:Galectins / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood*; D012044:Regression Analysis; D055771:Serbia
chemical_list: D015415:Biomarkers; D037161:Galectins; C038195:LGALS13 protein, human; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor; D003404:Creatinine
keywords: Balkan endemic nephropathy; epigenetics; placental growth factor; placental protein 13; tubulointerstitial kidney disease