title: Analysis of -11391G>A and +45>G polymorphisms of ADIPOQ gene in women with excessive weight gain during pregnancy.
abstract: OBJECTIVE
  The aim of our study was to evaluate the frequency of genotypes and alleles of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene in Polish women with excessive weight gain during pregnancy. A possible correlation between these polymorphisms and selected clinical and anthropometric parameters has been analyzed.
  
  
  METHODS
  A total of 153 pregnant Caucasian women of Polish origin with normal pre-pregnancy body mass were analyzed: 78 women with excessive weight gain (study group) and 75 women with normal weight gain during pregnancy (control group). The analysis of the polymorphisms was performed by PCR/RFLP.
  
  
  RESULTS
  The influence of the -11391G>A polymorphism on body mass and BMI values at the end of pregnancy (p < 0.05) was observed. We also detected a correlation of the +45T>G polymorphism with body mass at the end of pregnancy and pre-pregnancy WHR values (p < 0.05).
  
  
  CONCLUSIONS
  The observed effect of the -11391G>A polymorphism on the parameters assessed at the end of pregnancy (BMI and body mass), suggests a protective role of the -11391A genetic variant in excessive weight gain. It is claimed that the mutated +45G allele of the +45T>G ADIPOQ polymorphism shows a possible connection with higher pre-pregnancy WHR values and body mass at the end of pregnancy Our findings suggest a possible contribution of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene to the pathomechanism of excessive weight gain in pregnant women from the Polish population. This observation should be confirmed in a larger sample size study
authors.forename: Hubert
authors.initials: H
authors.lastname: Wolski
authors.forename: Witold
authors.initials: W
authors.lastname: Kraśnik
authors.forename: Anna
authors.initials: A
authors.lastname: Bogacz
authors.forename: Joanna
authors.initials: J
authors.lastname: Bartkowiak-Wieczorek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Greber
authors.forename: Bogusław
authors.initials: B
authors.lastname: Czerny
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Piątek
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D000483:Alleles; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D050177:Overweight / Q000235:genetics; D011044:Poland; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*; D012307:Risk Factors; D015430:Weight Gain / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin