title: Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies.
abstract: BACKGROUND
  It is widely understood that the 2 primary factors affecting dietary zinc absorption in adults are the quantities of zinc and phytate in the diet. Although a similar association of absorption to dietary zinc and phytate is presumed to exist in children, to our knowledge, no large-scale examination of the relation of zinc absorption to dietary and growth factors has been conducted.
  
  
  OBJECTIVE
  The goal was to apply an adult absorption model and related models to data from zinc absorption studies of infants and children in order to determine the nature of the relation of zinc absorption to dietary zinc and phytate, age, body size, and zinc homeostatic variables.
  
  
  METHODS
  Data from 236 children between 8 and 50 mo of age were obtained from stable-isotope studies of zinc absorption. Statistical and mechanistic models were fit to the data using linear and nonlinear regression analysis.
  
  
  RESULTS
  The effect of dietary phytate on zinc absorption when controlling for dietary zinc was very small and not statistically discernable (P = 0.29). A 500-mg/d increase in dietary phytate reduced absorbed zinc by <0.04 mg/d. Absorption was observed to vary with age, weight, and height (P < 0.0001) when controlling for dietary zinc. For example, absorption from 6 mg/d of dietary zinc increased by as much as 0.2 mg/d with a 12-mo increase in age. Absorption varied with weight and exchangeable zinc pool size (0.01 < P < 0.05) when controlling for dietary zinc and age.
  
  
  CONCLUSIONS
  The absence of a detectable phytate effect on zinc absorption raises caution about use of dietary phytate:zinc molar ratios to predict zinc bioavailability and does not support phytate reduction as a strategy to improve zinc status of young children. The effect of age on zinc absorption and the absence of a phytate effect should facilitate estimations of dietary zinc needs in young children.
authors.affiliation: Section of Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO leland.miller@ucdenver.edu.
authors.forename: Leland V
authors.initials: LV
authors.lastname: Miller
authors.affiliation: Section of Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO.
authors.forename: K Michael
authors.initials: KM
authors.lastname: Hambidge
authors.affiliation: Section of Nutrition, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO.
authors.forename: Nancy F
authors.initials: NF
authors.lastname: Krebs
mesh_terms: D002675:Child, Preschool; D004032:Diet; D005504:Food Analysis; D006801:Humans; D007223:Infant; D008954:Models, Biological; D010833:Phytic Acid / Q000008:administration & dosage* / Q000378:metabolism; D015032:Zinc / Q000378:metabolism*
chemical_list: D010833:Phytic Acid; D015032:Zinc
keywords: dietary phytate; dietary zinc; infants; mathematical modeling; young children; zinc absorption