title: [Origin of Hematopoietic Stem Cells in Bone Marrow--Endothelial to Hematopoietic Transition (EHT)?].
abstract: In contrast to primitive hematopoiesis, during embryonic definitive hematopoiesis, it has been demonstrated that multilineage hematopoietic stem/progenitor cells (HSPCs) arise from hemogenic endothelium, and the endothelial to hematopoietic transition (EHT) exists within the yolk sac, placenta, AGM, mouse head vascular and extraembryonic vessels. However, whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, including fetal liver and bone marrow, remains largely unknown. Recently, more and more researches showed that hematopoiesis within bone marrow had a close relationship with vascular endothelium development, too. This review summarizes the mechanism of EHT during embryo development, and discuss whether EHT exists in adult hematopoiesis.
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China. E-mail: chentong@fudan.edu.cn.
authors.forename: Tong
authors.initials: T
authors.lastname: Chen
mesh_terms: D000818:Animals; D001853:Bone Marrow; D002454:Cell Differentiation; D047108:Embryonic Development; D042783:Endothelial Cells; D004727:Endothelium; D004730:Endothelium, Vascular; D005260:Female; D055018:Hemangioblasts; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D051379:Mice; D010920:Placenta; D011247:Pregnancy; D015017:Yolk Sac