title: Association between low serum magnesium concentration and hyperuricemia.
abstract: OBJECTIVE
  To examine the cross-sectional associations between serum magnesium (Mg) and hyperuricemia (HU).
  
  
  METHODS
  2904 subjects were included in this study. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied to test the associations after adjusting for a number of potential confounding factors.
  
  
  RESULTS
  The relative odds of the prevalence of HU were significantly decreased by 0.65 times in the third quintile of serum Mg (OR 0.65, 95% CI 0.47-0.89), and 0.61 times in the fifth quintile (OR 0.61, 95% CI 0.45-0.83), compared with the lowest quintile: P for trend was 0.002. For males, the relative odds for HU were significantly decreased by 0.61 times in the third quintile of serum Mg (OR 0.61, 95% CI 0.42-0.89), 0.68 times in the fourth quintile (OR 0.68, 95% CI 0.47-0.97), and 0.59 times in the fifth quintile (OR 0.59, 95% CI 0.41-0.84) compared with the lowest quintile: P for trend was 0.003. However, no significant association was observed between serum Mg and HU for females.
  
  
  CONCLUSIONS
  Serum Mg is inversely associated with HU. This association remains valid for the male subgroup, but not for the female subgroup.
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Yi-lun
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Tuo
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Dong-xing
authors.initials: DX
authors.lastname: Xie
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Yu-sheng
authors.initials: YS
authors.lastname: Li
authors.affiliation: Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan Province, China, 410008.
authors.forename: Guang-hua
authors.initials: GH
authors.lastname: Lei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D033461:Hyperuricemia / Q000097:blood* / Q000175:diagnosis*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D008274:Magnesium