title: OS002. Comparison TNF-α level and pathogen periodontal microorganismbetween normal pregnant women, periodontitis pregnant women, and lateonset severe preeclampsia women.
abstract: BACKGROUND
  Preeclampsia Morbidity and Mortality is still high because of unknown etiology and pathogenesis. One of the theory about pathogenesis of preeclampsia in developing country is infections. Periodontitis is found in 10-60% preeclampsia cases in our center. So we held this research to evaluate the association between preeclampsia, periodontal pathogen, and TNF-α level.
  
  
  OBJECTIVE
  To compare and analyse the TNF-α level and pathogen periodontal microorganism between normal pregnant women, periodontitis pregnant women, and late onset severe preeclampsia women. Furthermore the research want to find any relationship between periodontitis and late onset severe preeclampsia.
  
  
  METHODS
  Analytic observational research with cross sectional study design at Soetomo Hospital from November 2010 until February 2011. Thirty patients divided into 3 groups, normal pregnant women, periodontitis pregnant women, and late onset severe preeclampsia women group. All patients were evaluated whether any periodontitis. Periodontal swab were performed and blood samples were taken from all of the patients. TNF-α level and pathogen periodontal microorganism were evaluated and analysed.
  
  
  RESULTS
  There is a significant difference TNF-α level between normal pregnant women, periodontitis pregnant women, and late onset severe preeclampsia p=0.000 (p<0.05). The highest TNF-α level is late onset preeclampsia, and the lowest is normal pregnant women. There is a significant difference pathogen periodontal microorganism between normal pregnant women, periodontitis pregnant women, and late onset severe preeclampsia p=0.001 (p<0.05). Porpyromonas ginggivalis is the most pathogen periodontal microorganism found at the samples. There is a significant difference TNF-α level between the samples with positive and negative pathogen periodontal microorganism p=0.04 (p<0.05).
  
  
  CONCLUSIONS
  There is a significant difference about the TNF-α level and pathogen periodontal microorganism between normal pregnant women, periodontitis pregnant women, and late onset severe preeclampsia. Furthermore the TNF-α level between the samples with positive and negative pathogen periodontal microorganism is significantly difference. Maybe periodontitis has association with late onset severe preeclampsia.
authors.affiliation: Obstetrics Gynaecologic (Fetomaternal Division).
authors.forename: A
authors.initials: A
authors.lastname: Akbar
authors.affiliation: Obstetrics Gynaecologic.
authors.forename: N D
authors.initials: ND
authors.lastname: Ariningtyas
authors.affiliation: Dentistry Division of Periodontal, Soetomo Hospital University of Airlangga, Surabaya, Indonesia.
authors.forename: A
authors.initials: A
authors.lastname: Krismariono
authors.affiliation: Obstetrics Gynaecologic (Fetomaternal Division).
authors.forename: E G
authors.initials: EG
authors.lastname: Dachlan