title: Metabolomics applied to the pancreatic islet.
abstract: Metabolomics, the characterization of the set of small molecules in a biological system, is advancing research in multiple areas of islet biology. Measuring a breadth of metabolites simultaneously provides a broad perspective on metabolic changes as the islets respond dynamically to metabolic fuels, hormones, or environmental stressors. As a result, metabolomics has the potential to provide new mechanistic insights into islet physiology and pathophysiology. Here we summarize advances in our understanding of islet physiology and the etiologies of type-1 and type-2 diabetes gained from metabolomics studies.
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University, Durham, NC 27701, United States.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Gooding
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University, Durham, NC 27701, United States.
authors.forename: Mette V
authors.initials: MV
authors.lastname: Jensen
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Departments of Pharmacology and Cancer Biology and Medicine, Duke University, Durham, NC 27701, United States. Electronic address: chris.newgard@dm.duke.edu.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Newgard
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism* / Q000502:physiology / Q000503:physiopathology; D055432:Metabolomics / Q000379:methods*
keywords: Diabetes; Islet; Lipidomics; Metabolic flux; Metabolism; Metabolomics