title: Effect of Xin Mai Jia on atherosclerosis in rats.
abstract: We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were established by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheology-related indices of blood samples were detected. Pathological changes in the right common carotid arterial tissues were also determined. The protein expression levels of endothelial nitric oxide synthase, angio-tensin-1, and endothelin-1 were determined by western blotting. XMJ reduced cholesterol, trigylecride, and low-density lipoprotein levels as well as blood viscosity, sedimentation, and hematocrit. Furthermore, XMJ alleviated vascular endothelial injury and reduced/eliminated atherosclerotic plaques. In contrast, XMJ significantly increased the endothelium-dependent relaxing response of the AS rat models. The western blotting results showed that XMJ upregulated endothelial nitric oxide synthase but downregulated angiotensin-1 and endothelin-1. XMJ prevented the development of AS by regulating blood lipid levels, hemorheology, and vascular function.
authors.affiliation: College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.affiliation: College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
authors.forename: G P
authors.initials: GP
authors.lastname: Pan
authors.affiliation: Puyang City Health School, Puyang, Henan, China.
authors.forename: M
authors.initials: M
authors.lastname: Jia
authors.affiliation: College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
authors.forename: Q Q
authors.initials: QQ
authors.lastname: Wang
authors.affiliation: Modern Technology Education Center, Xinxiang Medical University, Xinxiang, China.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Guo
authors.affiliation: College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
authors.forename: F R
authors.initials: FR
authors.lastname: Zhao
authors.affiliation: Modern Technology Education Center, Xinxiang Medical University, Xinxiang, China.
authors.forename: G L
authors.initials: GL
authors.lastname: Lei
authors.affiliation: School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China.
authors.forename: G R
authors.initials: GR
authors.lastname: Wan
authors.affiliation: The First Affiliated Hospital, ZhengZhou University, Zhengzhou, China.
authors.forename: G M
authors.initials: GM
authors.lastname: Wan
mesh_terms: D000809:Angiotensins / Q000096:biosynthesis / Q000097:blood; D000818:Animals; D050197:Atherosclerosis / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D002784:Cholesterol / Q000097:blood*; D059305:Diet, High-Fat; D019332:Endothelin-1 / Q000096:biosynthesis / Q000097:blood; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional; D009569:Nitric Oxide / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis / Q000097:blood; D051381:Rats; D014807:Vitamin D / Q000633:toxicity
chemical_list: D000809:Angiotensins; D019332:Endothelin-1; D008077:Lipoproteins, LDL; D014807:Vitamin D; D009569:Nitric Oxide; D002784:Cholesterol; D052250:Nitric Oxide Synthase Type III