title: Interstitial pregnancy treated with a single-dose of systemic methotrexate: A successful management.
abstract: Interstitial pregnancy is an ectopic pregnancy at high hemorrhagic risk. It often poses a diagnostic and therapeutic challenge to the clinician, with a significant risk of morbidity and mortality. It presents a difficult management problem with no absolute standard of care; the most appropriate treatment technique for these pregnancies remains controversial. We describe a case of unruptured interstitial pregnancy successfully treated with a single-dose of systemic methotrexate with subsequent ultrasound and serum beta human chorionic gonadotropin monitoring. Medical management can be a safe and successful option in selected cases that satisfy specific criteria and in women who are able to be monitored after treatment.
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Corioni
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Perelli
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Bianchi
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Cozzolino
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Luana
authors.initials: L
authors.lastname: Maggio
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Masini
authors.affiliation: Department of Maternal and Child Health, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50100 Florence, Italy.
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Coccia
keywords: Ectopic pregnancy; human chorionic gonadotropin monitoring; interstitial pregnancy; medical management; medical treatment; methotrexate; noninvasive treatment; ultrasound monitoring