title: Blood Plasma TGF- β1 Concentration in Sporadic Dilatative Pathology of Ascending Aorta: More Questions than Answers.
abstract: Transforming growth factor β1 (TGF- β1) is a cytokine that participates in a broad range of cellular regulatory processes and is associated with various diseases including aortic aneurysm. Increased TGF- β1 levels are associated with Marfan syndrome (MFS) caused by FBN1 mutations and subsequent defects in signaling system. We studied TGF- β1 levels in 62 patients with sporadic, non syndromic, dilatative pathology of ascending aorta (DPAA) and in reference group subjects (n = 212). An initial screening of 212 reference individuals identified TGF- β1 gender discrepancies and age-dependent cytokine increase in women. Patients with DPAA had increased levels of TGF- β1 in comparison to reference group subjects (median 7.7 ng/ml, range 2.1-25.3, and median 6.2 ng/ml, range 1.0-33.1, respectively). There is a significant association between TGF-β1 concentration and DPAA (OR 1.084, CI 1.027-1.144, p = 0.004) but the mechanisms of cause and effect have not been established yet. Slightly increased TGF-β1 concentrations in patients with sporadic DPAA in comparison to the reference subjects show a potential use of TGF-β1 as a biomarker for the disease. However, cytokine dependence on age, gender, and other unknown factors among individuals with no cardiovascular complains reduces its specificity for DPAA. We would also like to raise awareness regarding the choice of methods when measuring TGF-β1 levels with an emphasis on preanalytical phase and the choice of sample.
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania.
authors.forename: Ramune
authors.initials: R
authors.lastname: Sepetiene
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania.
authors.forename: Vaiva
authors.initials: V
authors.lastname: Patamsyte
authors.affiliation: Department of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, Lithuania.
authors.forename: Giedrius
authors.initials: G
authors.lastname: Zukovas
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania.
authors.forename: Giedre
authors.initials: G
authors.lastname: Jariene
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania.
authors.forename: Zita
authors.initials: Z
authors.lastname: Stanioniene
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania; Department of Cardiac, Thoracic and Vascular Surgery, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas, Lithuania.
authors.forename: Rimantas
authors.initials: R
authors.lastname: Benetis
authors.affiliation: Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Sukileliu 17, Kaunas, Lithuania.
authors.forename: Vaiva
authors.initials: V
authors.lastname: Lesauskaite
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000473:pathology*; D001018:Aortic Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D053773:Transforming Growth Factor beta1