title: Bioactive Structure of Membrane Lipids and Natural Products Elucidated by a Chemistry-Based Approach.
abstract: Determining the bioactive structure of membrane lipids is a new concept, which aims to examine the functions of lipids with respect to their three-dimensional structures. As lipids are dynamic by nature, their "structure" does not refer solely to a static picture but also to the local and global motions of the lipid molecules. We consider that interactions with lipids, which are completely defined by their structures, are controlled by the chemical, functional, and conformational matching between lipids and between lipid and protein. In this review, we describe recent advances in understanding the bioactive structures of membrane lipids bound to proteins and related molecules, including some of our recent results. By examining recent works on lipid-raft-related molecules, lipid-protein interactions, and membrane-active natural products, we discuss current perspectives on membrane structural biology.
authors.affiliation: JST ERATO, Lipid Active Structure Project, Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.|Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka, 563-0043, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Murata
authors.affiliation: JST ERATO, Lipid Active Structure Project, Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.|Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka, 563-0043, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sugiyama
authors.affiliation: JST ERATO, Lipid Active Structure Project, Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.|Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka, 563-0043, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Matsuoka
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka, 563-0043, Japan.|Department of Chemistry, Faculty and Graduate School of Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Matsumori
mesh_terms: D000818:Animals; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism*; D021962:Membrane Microdomains / Q000737:chemistry* / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins
keywords: NMR spectroscopy; fatty acids; lipid rafts; membrane proteins; sphingolipids