title: Avβ3 integrin: Pathogenetic role in osteotropic tumors.
abstract: The interplay of cancer cells and accessory cells within the microenvironment drives signals regulating the proliferation, migration and skeleton colonization. Osteotropism of tumor cells depends on chemokine activation, production of soluble factors and defective gene expression that cooperate within the metastatic niche to the bone resorbing functions of osteoclasts. Adhesion of cancer cells to the extracellular matrix is regulated by integrins as αvβ3 that enhances their invasiveness, pro-tumor angiogenesis and skeleton invasion. Therefore, αvβ3 signaling is implicated in enhancing osteotropism of breast and prostate cancers as well as of multiple myeloma. Targeting of αvβ3 has been adopted to restrain the tumor progression in several cancer models leading to improvement of overall survival as effect of the reduction of both tumor burden and osteotropism by malignant cells. Here, we review both the role of αvβ3 in malignant osteoclastogenesis and its potential targeting to restrain the bone colonization by skeleton invading cancers.
authors.affiliation: DIMO - Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Stucci
authors.affiliation: DIMO - Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', Italy. Electronic address: marco.tucci@uniba.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Tucci
authors.affiliation: DIMO - Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Passarelli
authors.affiliation: DIMO - Department of Biomedical Sciences and Clinical Oncology, University of Bari 'Aldo Moro', Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Silvestris
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology / Q000473:pathology / Q000556:secondary*; D049109:Cell Proliferation; D002470:Cell Survival; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000737:chemistry / Q000502:physiology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D015398:Signal Transduction / Q000502:physiology
chemical_list: D039302:Integrin alphaVbeta3
keywords: Bone metastasis; Cancer; Multiple myeloma; Target therapy; α(v)β(3)