title: Evaluation of the Effect of Modafinil on Cognitive Functions in Patients with Idiopathic Hypersomnia with P300.
abstract: BACKGROUND
  Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy and other excessive sleepiness. Whereas favorable effects of modafinil on cognitive functions have been shown in a large number of studies, there are very few reports presenting the effects of modafinil electrophysiologically. The aim of this study was to investigate the effects of modafinil on auditory P300 latency and amplitude electrophysiologically.
  
  
  METHODS
  Eighteen patients (age range: 16-48 years) with a diagnosis of idiopathic hypersomnia (IH) were included in the present study. As a standard treatment, 200 mg/day modafinil was administered to each patient. The P300 auditory test was performed for each patient before and at the end of 1 week of modafinil treatment.
  
  
  RESULTS
  After 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively). An increase in the P300 amplitudes was detected only at the Fz recording site, but not at Cz or Pz recording sites (P values for Fz, Cz, and Pz recording sites were 0.014, 0.100, and 0.05, respectively).
  
  
  CONCLUSIONS
  One week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients. Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.
authors.affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yaman
authors.affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Fatıma
authors.initials: F
authors.lastname: Karakaya
authors.affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Tuğçe
authors.initials: T
authors.lastname: Aydin
authors.affiliation: Department of Psychiatry, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Mayda
authors.affiliation: Department of Psychiatry, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Hail İbrahim
authors.initials: Hİ
authors.lastname: Güzel
authors.affiliation: Department of Neurology, University of Afyon Kocatepe, Faculty of Medicine, Afyonkarahisar, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Kayaalp
mesh_terms: D000293:Adolescent; D000328:Adult; D001559:Benzhydryl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D020177:Idiopathic Hypersomnia / Q000188:drug therapy / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D000077408:Modafinil; D064690:Wakefulness-Promoting Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D064690:Wakefulness-Promoting Agents; D000077408:Modafinil