title: Correlation of HLA-DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection.
abstract: BACKGROUND
  The aim of this study was to explore the correlation of gene polymorphisms of human leukocyte antigen-DQB1 (HLA-DQB1) with the infection outcome and replication status of hepatitis B virus (HBV) positive patients in the Xinjiang Uygur population in China.
  
  
  METHODS
  110 cases of chronic hepatitis B (CHB) of Xinjiang Uygur were examined clinically, which were named as the CHB group; 100 cases carrying chronic HBV (ASC) served as ASC group; 80 cases of self-limited HBV infection (RHBS) were recorded as RHBS group. Genotypes of HLA-DQB1 were detected by sequence specific primer-polymerase chain reaction (PCR-SSP) method, and the differences of gene frequency among groups were also compared. The distribution frequencies of the HLA-DQB1 gene under different replication states of HBV were compared.
  
  
  RESULTS
  The distribution frequency of DQB1*0201 in the RHBS group was higher than that of the ASC group (18.75%, 10.50%, χ(2) = 5.959, P < 0.05, OR = 2.257). The distribution frequency of DQB1*0201 in the CHB group was higher than that of the ASC group (17.73%, 10.50%, χ(2) = 5.363, P < 0.05, OR = 2.066). The distribution frequency of DQB1*0301 in the CHB group was higher than that of the ASC group (26.82%, 16.50%, χ(2) = 9.062, P < 0.05, OR = 2.349). The distribution frequency of DQB1*0303 in the CHB group was lower than that of the ASC group (19.55%, 31.00%, χ(2) = 10.996, P < 0.05, OR = 0.393). There was no statistically significant difference in the allele frequencies among all other groups. The distribution frequency of DQB1*0201 in the low replication group was higher than that of the high replication group (17.08%, 10.56%, χ(2) = 4.295, P < 0.05, OR = 1.939).
  
  
  CONCLUSIONS
  HLA-DQB1*0201 is a HBV resistance gene in Xinjiang Uygur. DQB1*0301 is correlated with continuous infection of HBV. DQB1*0303 is a susceptibility gene of ASC.
authors.affiliation: Department of Infectious, The Xinjiang Uygur Autonomous Region people's Hospital China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Infectious, The Xinjiang Uygur Autonomous Region people's Hospital China.
authors.forename: Fengcong
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Infectious, The Xinjiang Uygur Autonomous Region people's Hospital China.
authors.forename: Liu
authors.initials: L
authors.lastname: Lan
authors.affiliation: Department of Infectious, The Xinjiang Uygur Autonomous Region people's Hospital China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Infectious, The Xinjiang Uygur Autonomous Region people's Hospital China.
authors.forename: Liang
authors.initials: L
authors.lastname: Jun
keywords: HLA-DQB1; Hepatitis B virus; Uygur