title: Spectrum of Histopathological Findings in Live Donor Liver Graft Biopsies.
abstract: OBJECTIVE
  To study the spectrum of histopathological findings in live donor liver graft biopsies.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Histopathology Department, Shifa International Hospital, Islamabad, from January 2011 to March 2014.
  
  
  METHODS
  The biopsies were received in formalin and routinely processed. The changes encountered were divided into three categories: (i) new-onset post liver transplantation (LT) complications (early and late), (ii) acute rejection and (iii) recurrence of original disease. Banff schema 1997 of rejection activity index (RAI), modified histological activity index (mHAI) and recent literature were utilized for evaluation. The results were finalized in the light of clinical details along with relevant laboratory investigations and radiological findings.
  
  
  RESULTS
  Seventy eight percutaneous hepatic graft biopsies of 59 patients were evaluated. Among them, findings noticed in descending order of frequencies were Acute Cellular Rejection (ACR) in 37% (n=30), recurrent hepatitis C (HCV) in 22% (n=18), cholestasis/ductular proliferation in 27% (n=22), ischemic/reperfusion injury in 9.8% (n=8) and drug-induced liver injury in 3.7% (n=3). In the first six months post LT, ACR was the commonest cause of graft dysfunction, while recurrent HCV was noticed to be predominant reason after 6 months.
  
  
  CONCLUSIONS
  In this study, ACR was the most frequent finding in graft biopsies, followed by recurrent HCV. However, in first six months, ACR is the commonest histopathological finding while recurrent HCV was more frequently documented after 6 months.
authors.affiliation: Department of Histopathology, Shifa International Hospital, H-8/4,Pitras Bukhari Road, Islamabad.
authors.forename: Hina
authors.initials: H
authors.lastname: Tariq
authors.affiliation: Department of Histopathology, Shifa International Hospital, H-8/4,Pitras Bukhari Road, Islamabad.
authors.forename: Humaira
authors.initials: H
authors.lastname: Nasir
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006084:Graft Rejection / Q000209:etiology / Q000473:pathology*; D016174:Hepacivirus; D006526:Hepatitis C / Q000601:surgery; D018937:Hepatitis C Antibodies / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000821:virology; D012008:Recurrence; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D018937:Hepatitis C Antibodies