title: New geranylated flavanones from the fruits of Paulownia catalpifolia Gong Tong with their anti-proliferative activity on lung cancer cells A549.
abstract: Three new geranylated flavanones, named as paucatalinone A (1), B (2), and isopaucatalinone B (3), were isolated from the fruits of Paulownia catalpifolia Gong Tong (Scrophulariaceae). Their structures were well determined by means of IR, MS, 1D and 2D NMR, and CD techniques. Paucatalinone A (1) is the first sample as a dimeric geranylated flavanone derivative isolated from natural products. Paucatalinone A (1) displayed good antiproliferative effects on human lung cancer cells A549 and resulted in a clear increase of the percentage of cells in G1 phase and a decrease in the percentage of cells in S and G2/M phases in comparison with control cells.
authors.affiliation: Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
authors.forename: Tian-yang
authors.initials: TY
authors.lastname: Gao
authors.affiliation: Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, PR China.
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
authors.affiliation: Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China. Electronic address: twzsd@sina.com.
authors.forename: Wen-zhao
authors.initials: WZ
authors.lastname: Tang
authors.affiliation: Key Laboratory for Rare Disease of Shandong Province, Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 260062, PR China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medicine Sciences, Jinan 250022, PR China. Electronic address: xiaojing6@gmail.com.
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Pharmacology, School of Medicine, Shandong University, Jinan 250012, PR China.
authors.forename: Yun-xue
authors.initials: YX
authors.lastname: Zhao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D028083:Scrophulariaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; C000607709:paucatalinone A; C028610:flavanone
keywords: Antiproliferative activity; Geranylated flavanones; Lung cancer cells A549; Paulownia catalpifolia Gong Tong