title: Investigation of Marine-Derived Fungal Diversity and Their Exploitable Biological Activities.
abstract: Marine fungi are potential producers of bioactive compounds that may have pharmacological and medicinal applications. Fungi were cultured from marine brown algae and identified using multiple target genes to confirm phylogenetic placement. These target genes included the internal transcribed spacer (ITS), the nuclear large subunit (LSU), and the β-tubulin region. Various biological activities of marine-derived fungi were evaluated, including their antifungal, antioxidant and cellulolytic enzyme activities. As a result, a total of 50 fungi was isolated from the brown algae Sargassum sp. Among the 50 isolated fungi, Corollospora angusta was the dominant species in this study. The genus Arthrinium showed a relatively strong antifungal activity to all of the target plant pathogenic fungi. In particular, Arthrinium saccharicola KUC21221 showed high radical scavenging activity and the highest activities in terms of filter paper units (0.39 U/mL), endoglucanase activity (0.38 U/mL), and β-glucosidase activity (1.04 U/mL).
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. dress8@korea.ac.kr.
authors.forename: Joo-Hyun
authors.initials: JH
authors.lastname: Hong
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. skel@korea.ac.kr.
authors.forename: Seokyoon
authors.initials: S
authors.lastname: Jang
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. hym011@korea.ac.kr.
authors.forename: Young Mok
authors.initials: YM
authors.lastname: Heo
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. mihee1220@korea.ac.kr.
authors.forename: Mihee
authors.initials: M
authors.lastname: Min
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. ghksgnl27@korea.ac.kr.
authors.forename: Hwanhwi
authors.initials: H
authors.lastname: Lee
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. ymlee25@korea.ac.kr.
authors.forename: Young Min
authors.initials: YM
authors.lastname: Lee
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. hblee95@korea.ac.kr.
authors.forename: Hanbyul
authors.initials: H
authors.lastname: Lee
authors.affiliation: Division of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136-713, Korea. jae-jinkim@korea.ac.kr.
authors.forename: Jae-Jin
authors.initials: JJ
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D001688:Biological Products / Q000494:pharmacology; D004271:DNA, Fungal / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D005658:Fungi / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D000459:Phaeophyceae / Q000382:microbiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D001688:Biological Products; D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer
keywords: antioxidant activity; biological control; cellulolytic enzyme activity; marine fungi; phylogenetic analysis