title: Relationship Between an Osteoprotegerin Gene Polymorphism and Diabetic Vascular Complications.
abstract: BACKGROUND
  Osteoprotegerin (OPG), which was recently identified as a vascular marker, is increased in patients with diabetes mellitus (DM). This study evaluated the frequency of the OPG gene single nucleotide A163G polymorphism and its association with diabetic microvascular and macrovascular complications.
  
  
  METHODS
  The A163G polymorphism of the OPG gene was assessed in the peripheral blood of 116 patients with type 2 DM and 107 healthy subjects by polymerase chain reaction and restriction fragment length polymorphism. Microvascular and macrovascular complications were evaluated in diabetic patients.
  
  
  RESULTS
  Statistical analysis showed no significant difference in distribution of the OPG A163G polymorphism in the diabetic and control groups. Similarly, this polymorphism was not associated with microvascular or macrovascular complications.
  
  
  CONCLUSIONS
  This OPG polymorphism does not play a role in the development of microvascular and macrovascular complications in patients with DM.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Soysal-Atile
authors.forename: Sibel
authors.initials: S
authors.lastname: Guldiken
authors.forename: Tammam
authors.initials: T
authors.lastname: Sipahi
authors.forename: Fulya
authors.initials: F
authors.lastname: Yukcu
authors.forename: Betul
authors.initials: B
authors.lastname: Ekiz-Bilir
authors.forename: Serhat
authors.initials: S
authors.lastname: Huseyin
authors.forename: Armagan
authors.initials: A
authors.lastname: Tugrul
mesh_terms: D000328:Adult; D000368:Aged; D001483:Base Sequence; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D053244:Osteoprotegerin / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D053244:Osteoprotegerin