title: Unintended positive and negative effects of drugs on lipoproteins.
abstract: OBJECTIVE
  Dyslipidaemia is an important cardiovascular disease risk factor. Many drugs affect lipid profile and lipoprotein metabolism. We reviewed unintended effects of nonlipid modifying, commonly used medications on lipid profile and lipoprotein metabolism.
  
  
  RESULTS
  Several detrimental effects of many drug classes such as diuretics, antidepressant, anticonvulsant and antiretroviral drugs have been reported, whereas other drug classes such as antiobesity, alpha 1-blockers, oestrogens and thyroid replacement therapy were associated with positive effects.
  
  
  CONCLUSIONS
  Dyslipidaemia is a common side-effect of many medications. This should be taken into consideration, especially in patients at high risk of cardiovascular disease. Other drugs demonstrated positive effects on circulating lipids and lipoproteins. The impact of these unintended effects on atherosclerotic disease risk and progression is unclear.
authors.affiliation: aCardiovascular Research Group, School of Medicine, Core Technology Facility (3rd Floor), University of Manchester bCardiovascular Trials Unit, Central Manchester and Manchester Children University Hospital NHS Foundation Trust, Manchester, UK.
authors.forename: Tarza J
authors.initials: TJ
authors.lastname: Siahmansur
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Schofield
authors.forename: Shazli
authors.initials: S
authors.lastname: Azmi
authors.forename: Yifen
authors.initials: Y
authors.lastname: Liu
authors.forename: Paul N
authors.initials: PN
authors.lastname: Durrington
authors.forename: Handrean
authors.initials: H
authors.lastname: Soran
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000009:adverse effects / Q000494:pharmacology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000378:metabolism*; D004703:Endocrine System / Q000187:drug effects; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*
chemical_list: D002317:Cardiovascular Agents; D002491:Central Nervous System Agents; D008074:Lipoproteins