title: Successful treatment of adult-onset collapsing focal segmental glomerulosclerosis with rituximab.
abstract: Collapsing focal segmental glomerulosclerosis (FSGS), or collapsing glomerulopathy (CG), responds poorly to commonly employed therapies, with a high proportion of patients progressing to end-stage renal disease. We report an adult in a nephrotic state, diagnosed with minimal-change disease on biopsy, who failed to respond to steroids, calcineurin inhibitors (CNIs), mycophenolate mofetil and cyclophosphamide. Repeat biopsy showed CG. Treatment with 4 weekly doses of rituximab led to sustained remission of his nephrotic state. This is the first report of adult-onset CG that has responded favourably to rituximab. Rituximab could be a treatment option for patients with this difficult-to-treat condition.
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Raja
authors.initials: R
authors.lastname: Ramachandran
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Rajakumar
authors.affiliation: Department of Histopathology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Ritambhra
authors.initials: R
authors.lastname: Duseja
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Vinay
authors.initials: V
authors.lastname: Sakhuja
authors.affiliation: Department of Nephrology , Postgraduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Vivekanand
authors.initials: V
authors.lastname: Jha
keywords: collapsing glomerulopathy; focal segmental glomerulosclerosis; rituximab