title: Cardiovascular risk markers in pregnancies complicated by diabetes mellitus or preeclampsia.
abstract: OBJECTIVE
  To explore biomarkers indicating cardiovascular disease in pregnant women with diabetes or preeclampsia, since these women are at increased risk for future cardiovascular disease.
  
  
  METHODS
  EDTA-plasma from 262 women in gestational week 24-42 (healthy pregnancies n=71, preeclampsia n=105, type 2 diabetes n=17, gestational diabetes n=61, diabetes with preeclampsia n=8) was analyzed by immunoassay for neopterin, midregional pro-adrenomedullin (MR-proADM) and C-terminal pro-arginine vasopressin (CT-proAVP). The diabetes groups were also analyzed for midregional pro-atrial natriuretic peptide (MR-proANP), and compared to previously reported MR-proANP concentrations for healthy, normotensive and preeclamptic patients.
  
  
  RESULTS
  In contrast to preeclampsia, median plasma MR-proANP was not increased in pregnancies complicated by diabetes, but in fact lower, compared to healthy pregnancies. Neopterin was increased in diabetic pregnancies and in late onset preeclampsia, compared to healthy pregnancies. Median plasma MR-proADM was increased in pregnancies complicated by gestational diabetes or preeclampsia, compared to healthy pregnancies. Median plasma MR-proANP was increased in diabetic pregnancies complicated by preeclampsia compared to pregnant women with diabetes only.
  
  
  CONCLUSIONS
  Women with pregnancies complicated by diabetes mellitus or preeclampsia are at risk for future cardiovascular disease, but differ in circulating cardiovascular biomarker profile. A cardiovascular biomarker profiling during pregnancy might prove helpful in identifying women at risk for future cardiovascular disease, thus enabling targeted prophylactic interventions and follow-up.
authors.affiliation: Departments of Obstetrics and Gynaecology, Oslo University Hospital, Ullevål, P.O. Box 4956 Nydalen, 0424 Oslo, Norway.
authors.forename: Meryam
authors.initials: M
authors.lastname: Sugulle
authors.affiliation: Experimental and Clinical Research Center, a Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Herse
authors.affiliation: B.R.A.H.M.S Biomarkers, Clinical Diagnostics Division, Thermo Fisher Scientific, 16761 Hennigsdorf, Germany.
authors.forename: Marleen
authors.initials: M
authors.lastname: Seiler
authors.affiliation: Experimental and Clinical Research Center, a Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany; HELIOS Clinic, 13125 Berlin, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Dechend
authors.affiliation: Departments of Obstetrics and Gynaecology, Oslo University Hospital, Ullevål, P.O. Box 4956 Nydalen, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, P.O. Box 1078 Blindern, 0316 Oslo, Norway. Electronic address: a.c.staff@medisin.uio.no.
authors.forename: Anne Cathrine
authors.initials: AC
authors.lastname: Staff
keywords: Biomarkers; Cardiovascular disease; Diabetes mellitus; Preeclampsia; Pregnancy