title: A chiral phosphoric acid catalyst for asymmetric construction of 1,3-dioxanes.
abstract: A novel method of enantioselective 1,3-dioxane construction via a hemiacetalization/intramolecular oxy-Michael addition cascade by a chiral phosphoric acid catalyst was developed. The product was successfully transformed into an optically active 1,3-polyol motif, indicating that the proposed reaction can provide useful chiral building blocks for the de novo synthesis of polyketides.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan. asano.keisuke.5w@kyoto-u.ac.jp matsubara.seijiro.2e@kyoto-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Asano
authors.forename: Seijiro
authors.initials: S
authors.lastname: Matsubara