title: [Relationship between RAD51-G135C and XRCC3-C241T Single Nucleotide Polymorphisms and Onset of Acute Myeloid Leukemia].
abstract: OBJECTIVE
  To investigate the relationship between RAD51-G135C and XRCC3-C241T single nucleotide polymorphisms and onset of acute myeloid leukemia (AML).
  
  
  METHODS
  The study was performed in 2 groups: AML patient group and normal person group as control group. Genomic DNA was extracted from peripheral blood cells of 545 AML patients and 1 034 normal persons. Genotypes of RAD51-G135C and XRCC3-C241T were analyzed by TaqMan probe technology and the ralatienship between RAD51-G135C/XRCC3-C241T polymorphisms and onset of acute myeloid leukemia was investigated.
  
  
  RESULTS
  Compared with the control group, RAD51-G135C homozygous mutant (CC) could significantly increase the risk of AML patients (OR=3.07), and there was no statistical relationship between heterozygous mutant (GC) of RAD51-G135C and onset of AML. There was no statistical relationship between homozygous mutant (TT) of XRCC3-C241T and onset of AML, and the XRCC3-C241T heterozygous mutation type (CT) increased the risk of AML patients (OR=0.66).
  
  
  CONCLUSIONS
  RAD51-G135C homozygous mutant and XRCC3-C241T heterozygous mutation significantly increase the risk of the AML onset, which can provide more predictive value for incidence of AML.
authors.affiliation: Department of Hematology, Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Miao
authors.affiliation: Department of Hematology, Wuxi People's Hospital, Wuxi 214000, Jiangsu Province, China.
authors.forename: Xi-Feng
authors.initials: XF
authors.lastname: Qian
authors.affiliation: Department of Hematology, Wuxi People's Hospital, Wuxi 214000, Jiangsu Province, China.
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Yang
authors.affiliation: Department of Hematology, Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222000, Jiangsu Province, China. E-mail: zld060201@sina.com.
authors.forename: Li-Dong
authors.initials: LD
authors.lastname: Zhao
mesh_terms: D004268:DNA-Binding Proteins; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D020641:Polymorphism, Single Nucleotide; D051135:Rad51 Recombinase
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3; D051135:Rad51 Recombinase