title: [Clinical Efficacy of Radiotherapy Combined with Chemotherapy for Primary Mediastinal Large B-cell Lymphoma].
abstract: OBJECTIVE
  To explore the clinical efficacy of radiotherapy combined with chemotherapy for patients with primary mediastinal large B-cell lymphoma(PMLBCL).
  
  
  METHODS
  A total of 34 cases of PMLBCL were treated by radiotherapy combined with chemotherapy(radio-chemotherapy group), 28 cases of PMLBCL were treated by chemotherapy alone (single chemotherapy group as control). The clinical efficacy, side effects, long-term survival of the two group patients were compared.
  
  
  RESULTS
  The overall remission(OR) in the radio-chemotherapy group were higher than that in single chemotherapy group (P<0.05); the blood toxicity reaction, mucositis, radiation dermatitis in radio-chemotherapy group were higher than those in single chemotherapy group (P<0.05); the progress free survival(PFS) for 1 year in radio-chemotherapy group was higher than that in the single chemotherapy group (P<0.05), the local control (LC), PFS for 3 years in the radio-chemotherapy group were higher than those in the single chemotherapy group (P<0.05), the LC, OS, PFS for 5 years in the radio-chemotherapy group were higher than those in the single chemotherapy group (P<0.05).
  
  
  CONCLUSIONS
  The radiotherapy combined with chemotherapy has good clinical efficacy for patients with primary mediastinal large B-cell lymphoma, it has high rate of progression-free survival, it can be used as optimed scheme for treating PMLBCL, but the complications resulting from radio-chemotherapy should be prevented.
authors.affiliation: Department of Thoracic Surgery, Nanyang Central Hospital, Nanyang 473000, Henan Province, China.
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Su
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan Province, China.
authors.forename: Ying-Lu
authors.initials: YL
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Nanyang Central Hospital, Nanyang 473000, Henan Province, China. jinzhe7821@163.com.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Jin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D018572:Disease-Free Survival; D006801:Humans; D016393:Lymphoma, B-Cell; D016403:Lymphoma, Large B-Cell, Diffuse; D008479:Mediastinal Neoplasms; D016896:Treatment Outcome