title: Loss of Core 1-derived O-Glycans Decreases Breast Cancer Development in Mice.
abstract: Mucin-type core 1-derived O-glycans, one of the major types of O-glycans, are highly expressed in mammary gland epithelium. Abnormal O-glycans such as Tn antigen are found in over 90% of breast cancers; however, the in vivo role of these aberrant O-glycans in the etiology of breast cancer is unclear. We generated mice with mammary epithelial specific deletion of core 1-derived O-glycans. By crossing with two spontaneous mouse breast cancer models, we determined that loss of core 1-derived O-glycans delays the onset and progression of breast cancer development. Deficiency of core 1 O-glycosylation impaired the localization of Muc1, a major O-glycoprotein, on the apical surfaces of mammary epithelium. Signaling mediated by Muc1, which is critical for breast cancer development, was also defective in the absence of core 1 O-glycans. This study reveals an unexpected role of core 1-derived O-glycans in breast cancer development in mice.
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: Kai
authors.initials: K
authors.lastname: Song
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
authors.forename: Brett H
authors.initials: BH
authors.lastname: Herzog
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, 215006 Suzhou, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Fu
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, China-Japan Union Hospital of Jilin University, 130033 Changchun, China, and.
authors.forename: Minjia
authors.initials: M
authors.lastname: Sheng
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: Kirk
authors.initials: K
authors.lastname: Bergstrom
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: J Michael
authors.initials: JM
authors.lastname: McDaniel
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kondo
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: Samuel
authors.initials: S
authors.lastname: McGee
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, hong-chen@omrf.org.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: From the Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, Jiangsu Institute of Hematology, Collaborative Innovation Center of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, 215006 Suzhou, China, lijun-xia@omrf.org.
authors.forename: Lijun
authors.initials: L
authors.lastname: Xia
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D004195:Disease Models, Animal; D005260:Female; D018734:Genes, erbB-2; D006031:Glycosylation; D051379:Mice; D011134:Polysaccharides / Q000378:metabolism*
chemical_list: D011134:Polysaccharides
keywords: breast cancer; cell proliferation; glycosylation; mouse; mucin 1, cell surface associated (MUC1); tumor microenvironment