title: Association of rivaroxaban anticoagulation and spontaneous vitreous hemorrhage.
abstract: OBJECTIVE
  Rivaroxaban is an anticoagulant prescribed for the management of atrial fibrillation. We describe a correlation between rivaroxaban and spontaneous vitreous hemorrhage.
  
  
  METHODS
  Three patients developed spontaneous vitreous hemorrhage after initiating rivaroxaban anticoagulation. All 3 patients were taking an additional anticoagulant at the time of hemorrhage.
  
  
  CONCLUSIONS
  Rivaroxaban is increasingly prescribed as a replacement for warfarin sodium in the management of atrial fibrillation. Rivaroxaban anticoagulation may be associated with spontaneous vitreous hemorrhage. The risk of hemorrhage may be particularly elevated during the transition period when patients are switched from baseline anticoagulant to rivaroxaban therapy and are taking both anticoagulants simultaneously.
authors.affiliation: Retina Associates of Orange County, Laguna Hills, California.
authors.forename: Judy H
authors.initials: JH
authors.lastname: Jun
authors.affiliation: Retina Associates of Orange County, Laguna Hills, California2University of Southern California, Eye Institute, Keck School of Medicine, Los Angeles.
authors.forename: John C
authors.initials: JC
authors.lastname: Hwang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D000077144:Clopidogrel; D065427:Factor Xa Inhibitors / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D000069552:Rivaroxaban / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives; D014792:Visual Acuity; D014823:Vitreous Hemorrhage / Q000139:chemically induced* / Q000503:physiopathology; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D010975:Platelet Aggregation Inhibitors; D014859:Warfarin; D000069552:Rivaroxaban; D000077144:Clopidogrel; D013988:Ticlopidine