title: [The Use of Thromboelastometry and Tranexamic Acid Reduces Blood Loss and Transfusion Requirements in Cardiac Surgery under Cardiopulmonary Bypass].
abstract: BACKGROUND
  We evaluated whether using thromboelastometry and tranexamic acid influenced blood loss and transfusion requirements in cardiac surgery requiring cardiopulmonary bypass.
  
  
  METHODS
  We perfomed a retrospective analysis examining perioperative coagulation results, and the transfusion requirements of concentrated red cells (CRCs), fresh frozen plasma (FFP) and platelet administration between 12 months before and 10 months after thromboelastometry and tranexamic acid had been introduced in our institution. We also recorded patients' demographic details, the surgery performed and patient outcomes.
  
  
  RESULTS
  After the introduction of thromboelastometry and tranexamic acid, fewer units of CRC were transfused during surgery, and fewer patients required postoperative CRC transfusion. Intra- and postoperative FFP requirements were also reduced. Intraoperative blood loss, blood loss in the first 24 hr after surgery, and length of hospital stay were also reduced.
  
  
  CONCLUSIONS
  The use of ROTEM and tranexamic acid can potentially reduce blood loss and transfusion requirements in cardiac surgery.
authors.forename: Junko
authors.initials: J
authors.lastname: Ichikawa
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Kodaka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kitahara
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Sato
authors.forename: Keiko
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Nakano
authors.forename: Makiko
authors.initials: M
authors.lastname: Komori
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013916:Thrombelastography; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D014148:Tranexamic Acid