title: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.
abstract: In theory, pluripotent stem cells can give rise to all somatic cell types found in the human body. The ability to generate renewable sources of human cells has enormous potential to improve human health and wealth. One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. To tackle this issue a synthetic polymer surface is used.
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Baltasar Lucendo
authors.initials: BL
authors.lastname: Villarin
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Cameron
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Dagmara
authors.initials: D
authors.lastname: Szkolnicka
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Hassan
authors.initials: H
authors.lastname: Rashidi
authors.affiliation: Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
authors.forename: Nicola
authors.initials: N
authors.lastname: Bates
authors.affiliation: Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Kimber
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Oliver
authors.initials: O
authors.lastname: Flint
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Forbes
authors.affiliation: MRC Centre for Inflammation Research, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
authors.forename: John P
authors.initials: JP
authors.lastname: Iredale
authors.affiliation: School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh, EH9 3FJ, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
authors.affiliation: MRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Hay
mesh_terms: D002454:Cell Differentiation; D002478:Cells, Cultured; D053595:Embryonic Stem Cells / Q000166:cytology; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*; D011786:Quality Control; D014162:Transfection
chemical_list: D011108:Polymers
keywords: differentiation; gene signature; hepatocytes; pluripotent stem cells; polymers