title: Multimodality imaging of splenic sclerosing angiomatoid nodular transformation.
abstract: Sclerosing angiomatoid nodular transformation (SANT) is an exceedingly rare, benign and proliferative vascular lesion that arises from the splenic red pulp. It is often an incidental finding on imaging. The diagnosis of SANT is confirmed via histopathological examination of the resected spleen. Herein, we present a case of SANT and describe its typical imaging characteristics. An asymptomatic 39-year-old man was found to have a 3.1 cm × 2.7 cm × 2.3 cm hypoechoic splenic lesion during abdominal ultrasonography, which was performed to investigate his elevated gamma-glutamyl transpeptidase and alanine transaminase levels. Contrast-enhanced computed tomography suggested a vascular splenic lesion, while magnetic resonance imaging demonstrated features consistent with SANT. In view of the increasing size of the lesion on follow-up imaging, the patient elected for splenectomy. Histopathological examination confirmed SANT, and the lesion was completely resected by laparoscopic splenectomy.
authors.affiliation: Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
authors.forename: Hock Tai Gavin
authors.initials: HT
authors.lastname: Lim
authors.affiliation: Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
authors.forename: Cher Heng
authors.initials: CH
authors.lastname: Tan
authors.affiliation: Trauma and Acute Care Surgery, Department of Surgery, Tan Tock Seng Hospital, Singapore ; Surgical High Dependency Unit, Division of Surgery, Department of General Surgery, Tan Tock Seng Hospital, Singapore.
authors.forename: Li Tserng
authors.initials: LT
authors.lastname: Teo
authors.affiliation: Department of Pathology, Tan Tock Seng Hospital, Singapore.
authors.forename: Chi Shern Bernard
authors.initials: CS
authors.lastname: Ho
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D049109:Cell Proliferation; D003287:Contrast Media / Q000737:chemistry; D018450:Disease Progression; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D033162:Incidental Findings; D010535:Laparoscopy; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D013154:Spleen / Q000000981:diagnostic imaging*; D013156:Splenectomy; D013158:Splenic Diseases / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D003287:Contrast Media; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase
keywords: SANT; laparoscopic splenectomy; sclerosing angiomatoid nodular transformation