title: Effects of enzyme replacement therapy on immune function in ADA deficiency patient.
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nakazawa
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan.
authors.forename: Toshinao
authors.initials: T
authors.lastname: Kawai
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Uchiyama
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Goto
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Watanabe
authors.affiliation: Department of General Pediatrics &Interdisciplinary Medicine, National Center for Child Health and Development, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Maekawa
authors.affiliation: Department of General Pediatrics &Interdisciplinary Medicine, National Center for Child Health and Development, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ishiguro
authors.affiliation: Clinical Laboratory Medicine, National Center for Child Health and Development, Japan.
authors.forename: Torayuki
authors.initials: T
authors.lastname: Okuyama
authors.affiliation: Center for Stem Cell Biology and Regenerative Medicine, Tokyo University, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Otsu
authors.affiliation: Department of Pediatrics, Hokkaido University, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Department of Biochemistry, Duke University Medical Center, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Hershfield
authors.affiliation: Department of Pediatrics, Hokkaido University, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
authors.affiliation: Department of Human Genetics, National Research Institute for Child Health and Development, Japan. Electronic address: onodera-m@ncchd.go.jp.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Onodera
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood / Q000172:deficiency* / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D000293:Adolescent; D000361:Agammaglobulinemia / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D056947:Enzyme Replacement Therapy / Q000379:methods*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018655:Lymphocyte Count; D016511:Severe Combined Immunodeficiency / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000243:Adenosine Deaminase; C051409:pegademase bovine
keywords: Adenosine deaminase deficiency; Enzyme replacement therapy; Immune reconstitution; PEG-ADA; Severe combined immunodeficiency; Stem cell gene therapy