title: Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis.
abstract: BACKGROUND
  We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis.
  
  
  METHODS
  This cross-sectional study involved 79 patients infected with Schistosoma mansoni with severe or mild/moderate periportal fibrosis. Serum concentrations of mannose-binding lectin were obtained by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Higher serum level of mannose-binding lectin was significantly associated with advanced periportal fibrosis.
  
  
  CONCLUSIONS
  Mannose-binding lectin may contribute to liver pathology in schistosomiasis and may represent a risk factor for advanced periportal fibrosis in the Brazilian population studied.
authors.affiliation: Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
authors.forename: Paula Carolina Valença
authors.initials: PC
authors.lastname: Silva
authors.affiliation: Laboratório de Biologia Molecular, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Adriana Vieira
authors.initials: AV
authors.lastname: Gomes
authors.affiliation: Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Georgea Gertrudes de Oliveira Mendes
authors.initials: GG
authors.lastname: Cahu
authors.affiliation: Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Maria Rosângela Cunha Duarte
authors.initials: MR
authors.lastname: Coêlho
authors.affiliation: Laboratório de Biologia Molecular, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Maria Tereza Cartaxo
authors.initials: MT
authors.lastname: Muniz
authors.affiliation: Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Ana Lúcia Coutinho
authors.initials: AL
authors.lastname: Domingues
mesh_terms: D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000469:parasitology* / Q000473:pathology; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D011168:Portal System / Q000469:parasitology*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000150:complications / Q000473:pathology; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D037601:Mannose-Binding Lectin