title: Development of the human fetal hippocampal formation during early second trimester.
abstract: Development of the fetal hippocampal formation has been difficult to fully describe because of rapid changes in its shape during the fetal period. The aims of this study were to: (1) segment the fetal hippocampal formation using 7.0 T MR images from 41 specimens with gestational ages ranging from 14 to 22 weeks and (2) reveal the developmental course of the fetal hippocampal formation using volume and shape analyses. Differences in hemispheric volume were observed, with the right hippocampi being larger than the left. Absolute volume changes showed a linear increase, while relative volume changes demonstrated an inverted-U shape trend during this period. Together these exhibited a variable developmental rate among different regions of the fetal brain. Different sub-regional growth of the fetal hippocampal formation was specifically observed using shape analysis. The fetal hippocampal formation possessed a prominent medial-lateral bidirectional shape growth pattern during its rotation process. Our results provide additional insight into 3D hippocampal morphology in the assessment of fetal brain development and can be used as a reference for future hippocampal studies.
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China; Laboratory of Neuroimaging, Institute of Neuroimaging and Informatics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Xinting
authors.initials: X
authors.lastname: Ge
authors.affiliation: Laboratory of Neuroimaging, Institute of Neuroimaging and Informatics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Laboratory of Neuroimaging, Institute of Neuroimaging and Informatics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Junning
authors.initials: J
authors.lastname: Li
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021 Jinan, Shandong, China.
authors.forename: Zhonghe
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China; Department of MRI, Shandong Institute for Medical Imaging, 250021 Jinan, Shandong, China.
authors.forename: Xiangtao
authors.initials: X
authors.lastname: Lin
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Ge
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Junhai
authors.initials: J
authors.lastname: Xu
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China; Department of Medical Imaging, Provincial Hospital Affiliated to Shandong University, 250021 Jinan, Shandong, China.
authors.forename: Qiaowen
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Leng
authors.affiliation: Department of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009 Nanjing, Jiangsu, China.
authors.forename: Gaojun
authors.initials: G
authors.lastname: Teng
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Meng
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Radiology, Zhong Da Hospital, Southeast University School of Clinical Medicine, 210009 Nanjing, Jiangsu, China.
authors.forename: Fengchao
authors.initials: F
authors.lastname: Zang
authors.affiliation: Laboratory of Neuroimaging, Institute of Neuroimaging and Informatics, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA. Electronic address: toga@loni.usc.edu.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.affiliation: Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorders, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China. Electronic address: liusw@sdu.edu.cn.
authors.forename: Shuwei
authors.initials: S
authors.lastname: Liu
mesh_terms: D005260:Female; D005865:Gestational Age; D006624:Hippocampus / Q000196:embryology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second
keywords: Fetal brain development; High resolution MRI; Hippocampal formation; Shape analysis