title: Biomimetic synthesized chiral mesoporous silica: Structures and controlled release functions as drug carrier.
abstract: This work initially illustrated the formation mechanism of chiral mesoporous silica (CMS) in a brand new insight named biomimetic synthesis. Three kinds of biomimetic synthesized CMS (B-CMS, including B-CMS1, B-CMS2 and B-CMS3) were prepared using different pH or stirring rate condition, and their characteristics were tested with transmission electron microscope and small angle X-ray diffraction. The model drug indomethacin was loaded into B-CMS and drug loading content was measured using ultraviolet spectroscopy. The result suggested that pH condition influenced energetics of self-assembly process, mainly packing energetics of the surfactant, while stirring rate was the more dominant factor to determine particle length. In application, indomethacin loading content was measured to be 35.3%, 34.8% and 35.1% for indomethacin loaded B-CMS1, indomethacin loaded B-CMS2 and indomethacin loaded B-CMS3. After loading indomethacin into B-CMS carriers, surface area, pore volume and pore diameter of B-CMS carriers were reduced. B-CMS converted crystalline state of indomethacin to amorphous state, leading to the improved indomethacin dissolution. B-CMS1 controlled drug release without burst-release, while B-CMS2 and B-CMS3 released indomethacin faster than B-CMS1, demonstrating that the particle length, the ordered lever of multiple helixes, the curvature degree of helical channels and pore diameter greatly contributed to the release behavior of indomethacin loaded B-CMS.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China. Electronic address: xl2013109@163.com.
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China.
authors.forename: Baixue
authors.initials: B
authors.lastname: Yang
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Bao
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China.
authors.forename: Weisan
authors.initials: W
authors.lastname: Pan
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Wenhua RD 103, 110016, China. Electronic address: li_sanming2013@163.com.
authors.forename: Sanming
authors.initials: S
authors.lastname: Li
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000008:administration & dosage / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D009584:Nitrogen / Q000737:chemistry; D019308:Palmitic Acid / Q000737:chemistry; D011437:Propylamines; D012821:Silanes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011437:Propylamines; D012821:Silanes; D019308:Palmitic Acid; C040733:tetraethoxysilane; D012822:Silicon Dioxide; C477625:amino-propyl-triethoxysilane; D009584:Nitrogen; D007213:Indomethacin
keywords: Biomimetic synthesis; Chiral mesoporous silica; Controlled release