title: Gene-Diet Interaction between SIRT6 and Soybean Intake for Different Levels of Pulse Wave Velocity.
abstract: Soybean is a common food for the Chinese people. We aimed to investigate the risk for brachial ankle pulse wave velocity (baPWV) with inflammatory-related SNPs and soybean. baPWV was measured, and 16 inflammatory-related SNPs located on ADIPOQ, CDH13, SIRT3, SIRT6, CXCL12, CXCR4, NOS1, PON1 and CDKN2B were genotyped in 1749 Chinese participants recruited from various communities. ADIPOQ rs12495941 (GT/TT vs. GG: crude OR = 1.27, p = 0.044) and SIRT6 rs107251 (CT/TT vs. CC: crude OR = 0.74, p = 0.009) were associated with abnormal baPWV (baPWV ≥ 1700 cm/s). After adjustment for conventional environmental risk factors, rs12495941 was associated with abnormal baPWV (GT/TT vs. GG: adjusted OR = 1.43, p = 0.011), but the association between rs107251 and abnormal baPWV was not significant (CT/TT vs. CC: adjusted OR = 0.83, p = 0.173). The interaction between rs107251 and soybean intake for different levels of baPWV was statistically significant (p = 0.017). Compared with a high level of soybean intake, a low level of soybean intake can significantly decrease the risk of abnormal baPWV in individuals of rs107251 CT/TT genotypes (≤ 100 vs. > 100 g/week: adjusted OR = 0.542, p = 0.003). In this study, associations between ADIPOQ rs12495941, SIRT6 rs107251 and baPWV, as well as an interaction between SIRT6 rs107251 and soybean intake for different levels of baPWV were found.
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. kexin_sun@bjmu.edu.cn.
authors.forename: Kexin
authors.initials: K
authors.lastname: Sun
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. doublex1990@live.cn.
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiang
authors.affiliation: Fangshan District Center for Disease Control and Prevention, Beijing 102401, China. sophia8063@163.com.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: Fangshan District Center for Disease Control and Prevention, Beijing 102401, China. fshcdcmb@yeah.net.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. xueyingqin@gmail.com.
authors.forename: Xueying
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. qywu118@163.com.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. tangxun@bjmu.edu.cn.
authors.forename: Xun
authors.initials: X
authors.lastname: Tang
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. pei.gao@163.com.
authors.forename: Pei
authors.initials: P
authors.lastname: Gao
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. jing2k9@gmail.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. twu@bjmu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. dafangchen@bjmu.edu.cn.
authors.forename: Dafang
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. yhhu@bjmu.edu.cn.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Hu
mesh_terms: D052242:Adiponectin / Q000235:genetics; D000368:Aged; D005260:Female; D059647:Gene-Environment Interaction; D056426:Genetic Loci; D006439:Hemodynamics / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D063177:Pulse Wave Analysis; D037761:Sirtuins / Q000235:genetics*; D030262:Soybean Proteins / Q000494:pharmacology*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D030262:Soybean Proteins; C516592:SIRT6 protein, human; D037761:Sirtuins
keywords: ADIPOQ; SIRT6; atherosclerosis; brachial ankle pulse wave velocity; genetic polymorphisms; inflammation; interaction; soybean