title: Oxomollugin, a potential inhibitor of lipopolysaccharide-induced nitric oxide production including nuclear factor kappa B signals.
abstract: Mollugin, a naphthoquinone derivative, was reported to possess various biological activities such as anti-inflammatory and anti-tumor activity. Mollugin isolated from Rubia tinctorum roots inhibited lipopolysaccharide-induced nitric oxide (NO) production in RAW264.7 macrophages. However, mollugin synthesized for further investigation of its anti-inflammatory mechanism showed weak activity in addition to unstable assay results. From the result of analysis on a degradation product of mollugin, oxomollugin was found to be the main active substance of mollugin degradation, showing a potent inhibitory activity on NO-production including nuclear factor kappa B signals.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan, moritah@hoshi.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Hitomi
authors.initials: H
authors.lastname: Nishino
authors.forename: Yuki
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kakubari
authors.forename: Asami
authors.initials: A
authors.lastname: Nakata
authors.forename: Jun
authors.initials: J
authors.lastname: Deguchi
authors.forename: Alfarius Eko
authors.initials: AE
authors.lastname: Nugroho
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000378:metabolism; D011714:Pyrans; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D008070:Lipopolysaccharides; D016328:NF-kappa B; D011714:Pyrans; C000613478:oxomollugin; D009569:Nitric Oxide; C046245:rubimaillin