title: S100B brain expression and plasma concentrations in a preeclampsia rat model.
abstract: OBJECTIVE
  To assess brain damage using the neuroinflammation marker S100B in a preeclampsia rat model.
  
  
  METHODS
  Non-pregnant and pregnant rats were infused with saline or low-dose-endotoxin on day 14 of pregnancy. S100B expression in the brain (immunohistochemistry) and S100B plasma concentrations (ELISA) were studied.
  
  
  RESULTS
  No differences in S100B expression in brain tissue were observed between the four groups. Pregnant endotoxin treated animals did not show increased levels of plasma S100B levels as compared with control pregnant rats, while significantly higher plasma S100B levels were found in non-pregnant endotoxin versus pregnant endotoxin infused rats.
  
  
  CONCLUSIONS
  Pregnancy nor experimental preeclampsia, alter S100B in rat brain, or in plasma. Increased plasma S100B in non-pregnant endotoxin-treated rats may indicate brain injury in these rats, whereas pregnancy might be protective.
authors.affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: M N
authors.initials: MN
authors.lastname: van Ijsselmuiden
authors.affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wiegman
authors.affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: G G
authors.initials: GG
authors.lastname: Zeeman
authors.affiliation: Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Faas