title: Preliminary experience with drug-coated balloon angioplasty in primary percutaneous coronary intervention.
abstract: We evaluated the clinical feasibility of using drug-coated balloon (DCB) angioplasty in patients undergoing primary percutaneous coronary intervention (PPCI). Between January 2010 to September 2014, 89 ST-elevation myocardial infarction patients (83% male, mean age 59 ± 14 years) with a total of 89 coronary lesions were treated with DCB during PPCI. Clinical outcomes are reported at 30 d follow-up. Left anterior descending artery was the most common target vessel for PCI (37%). Twenty-eight percent of the patients had underlying diabetes mellitus. Mean left ventricular ejection fraction was 44% ± 11%. DCB-only PCI was the predominant approach (96%) with the remaining 4% of patients receiving bail-out stenting. Thrombolysis in Myocardial Infarction (TIMI) 3 flow was successfully restored in 98% of patients. An average of 1.2 ± 0.5 DCB were used per patient, with mean DCB diameter of 2.6 ± 0.5 mm and average length of 23.2 ± 10.2 mm. At 30-d follow-up, there were 4 deaths (4.5%). No patients experienced abrupt closure of the infarct-related artery and there was no reported target-lesion failure. Our preliminary experience showed that DCB angioplasty in PPCI was feasible and associated with a high rate of TIMI 3 flow and low 30-d ischaemic event.
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Hee Hwa
authors.initials: HH
authors.lastname: Ho
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Julian
authors.initials: J
authors.lastname: Tan
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Yau Wei
authors.initials: YW
authors.lastname: Ooi
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Kwok Kong
authors.initials: KK
authors.lastname: Loh
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Than Htike
authors.initials: TH
authors.lastname: Aung
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Nwe Tun
authors.initials: NT
authors.lastname: Yin
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Dasdo Antonius
authors.initials: DA
authors.lastname: Sinaga
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Fahim Haider
authors.initials: FH
authors.lastname: Jafary
authors.affiliation: Hee Hwa Ho, Julian Tan, Yau Wei Ooi, Kwok Kong Loh, Than Htike Aung, Nwe Tun Yin, Dasdo Antonius Sinaga, Fahim Haider Jafary, Paul Jau Lueng Ong, Department of Cardiology, Tan Tock Seng Hospital, 308433 Singapore, Singapore.
authors.forename: Paul Jau Lueng
authors.initials: PJ
authors.lastname: Ong
keywords: Acute myocardial infarction; Drug coated balloon; Efficacy; Primary angioplasty; Safety