title: PP101. Preeclampsia and pregnancy induced hypertension and carotid artery atherosclerosis.
abstract: BACKGROUND
  Recent studies indicated preeclampsia (PE) and pregnancy-induced hypertension (PIH) as risk factors for cardiovascular diseases in young women. Women with a history of preeclampsia face double the risk of a heart disease during the 5-15years after pregnancy. We assessed the impact of these factors on endothelial function, atherosclerotic changes and lipid metabolism in young women with a history of preeclampsia and pregnancy-induced hypertension.
  
  
  OBJECTIVE
  The aim of this study was to examine whether women with a history of preeclampsia more often show signs of atherosclerosis compared with control group
  
  
  METHODS
  We analyzed serum levels of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG). Endothelium-dependent vasodilation and carotid artery intima-media thickness (CA-IMT) were evaluated in 18 patients with a history of PE, 16 with a history of PIH and 17 healthy controls (CN). Inter-group differences were calculated using Student's t-test.
  
  
  RESULTS
  We found a worse lipid profile among women with PE and PIH. LDL-C was increased significantly in PE and PIH (PE: 3.17mmol/l [SD 0.50] and PIH: 3.37mmol/l [SD 0.48] vs CN: 2.83mmol/l [SD 0.35], p<0.05); TC and TG were higher in the PE and PIH groups, but not significantly (p>0.05). Compared to controls, endothelium-dependent vasodilation was significantly reduced in PE and PIH patients (10.5% [SD 4.3] and 8.8% [SD 3.1] vs 14.5% [SD 3.6], p<0.05). The mean combined CA-IMT was significantly higher in PE and PIH patients (0.66mm [SD 0.08] and 0.63mm [SD 0.09], respectively vs 0.52mm [SD 0.04]).
  
  
  CONCLUSIONS
  We conclude that impaired endothelial vasoreactivity and increased CA-IMT are prevalent in women with a history of PE and PIH and are associated with traditional risk factors that strongly suggest that PE and PIH could be non-traditional cardiovascular risk factors.
authors.affiliation: V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors.forename: N
authors.initials: N
authors.lastname: Sharashkina
authors.affiliation: V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors.forename: N
authors.initials: N
authors.lastname: Runikhina
authors.affiliation: V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors.forename: O
authors.initials: O
authors.lastname: Tkacheva
authors.affiliation: V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors.forename: I
authors.initials: I
authors.lastname: Novikova