title: The unpredictability of prolonged activation of stress response pathways.
abstract: In response to stress, cellular compartments activate signaling pathways that mediate transcriptional programs to promote survival and reestablish homeostasis. Manipulation of the magnitude and duration of the activation of stress responses has been proposed as a strategy to prevent or repair the damage associated with aging or degenerative diseases. However, as these pathways likely evolved to respond specifically to transient perturbations, the unpredictability of prolonged activation should be considered.
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
authors.forename: Lilian T
authors.initials: LT
authors.lastname: Lamech
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 BCMB Allied Program, Weill Cornell Medical College, New York, NY 10065 haynesc@mskcc.org.
authors.forename: Cole M
authors.initials: CM
authors.lastname: Haynes
mesh_terms: D051697:Activating Transcription Factor 1 / Q000378:metabolism; D000375:Aging / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D000076249:Heat Shock Transcription Factors; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D057165:Proteostasis Deficiencies / Q000503:physiopathology*; D000071701:Regulatory Factor X Transcription Factors; D015398:Signal Transduction; D013312:Stress, Physiological / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation; D056811:Unfolded Protein Response / Q000502:physiology*
chemical_list: D051697:Activating Transcription Factor 1; D004268:DNA-Binding Proteins; D000076249:Heat Shock Transcription Factors; D000071701:Regulatory Factor X Transcription Factors; D014157:Transcription Factors