title: [Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin].
abstract: OBJECTIVE
  To study the synergism between neuropeptides and lithium ions.
  
  
  METHODS
  An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used.
  
  
  RESULTS
  A complex of experimental studies revealed that the effect of cerebrolysin is influenced by the synergism between lithium ions and the neuropeptide contentof this drug. Pharmacokinetic synergism promotes the accumulation of lithium in brain tissues during cerebrolysin treatment. The existence of the pharmacokinetic synergism is evident from the potentiation of neuroprotective effects of the drug under the action of lithium ions established in the model of stroke.
  
  
  CONCLUSIONS
  Lithium ions potentiate neuroprotective effects of cerebrolysin.
authors.affiliation: Ivanovo State Medical Academy, Ivanovo.
authors.forename: O A
authors.initials: OA
authors.lastname: Gromova
authors.affiliation: Russian Satellite Center, Trace Elements Institute for UNESCO, Moscow.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Torshin
authors.affiliation: Ivanovo State Medical Academy, Ivanovo.
authors.forename: I V
authors.initials: IV
authors.lastname: Gogoleva
authors.affiliation: Ivanovo State Medical Academy, Ivanovo.
authors.forename: A V
authors.initials: AV
authors.lastname: Pronin
authors.affiliation: Neurology Research Center, Russian Academy of Sciences, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashuk
authors.affiliation: Neurology Research Center, Russian Academy of Sciences, Moscow.
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.affiliation: Neurology Research Center, Russian Academy of Sciences, Moscow.
authors.forename: E E
authors.initials: EE
authors.lastname: Genrikhs
authors.affiliation: Ivanovo State Medical Academy, Ivanovo.
authors.forename: V I
authors.initials: VI
authors.lastname: Demidov
authors.affiliation: Russian Satellite Center, Trace Elements Institute for UNESCO, Moscow.
authors.forename: A Yu
authors.initials: AY
authors.lastname: Volkov
authors.affiliation: Ivanovo State Medical Academy, Ivanovo.
authors.forename: G L
authors.initials: GL
authors.lastname: Khaspekov
authors.affiliation: Neurology Research Center, Russian Academy of Sciences, Moscow.
authors.forename: O P
authors.initials: OP
authors.lastname: Alexandrova
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004357:Drug Synergism; D004745:Enkephalins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019004:Galanin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018698:Glutamic Acid / Q000633:toxicity; D047908:Intracellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018020:Lithium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000068797:Orexins; D051381:Rats; D011919:Rats, Inbred Strains; D020521:Stroke / Q000188:drug therapy / Q000473:pathology
chemical_list: D000596:Amino Acids; D004745:Enkephalins; D047908:Intracellular Signaling Peptides and Proteins; D018020:Lithium Compounds; D009479:Neuropeptides; D018696:Neuroprotective Agents; D000068797:Orexins; C006952:cerebrolysin; D018698:Glutamic Acid; D019004:Galanin