title: Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release.
abstract: Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.
authors.affiliation: Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, 00076 Aalto (Finland) http://chemtech.aalto.fi/bihy.
authors.forename: Sami
authors.initials: S
authors.lastname: Nummelin
authors.affiliation: Department of Applied Physics, Aalto University School of Science, 00076 Aalto (Finland).
authors.forename: Ville
authors.initials: V
authors.lastname: Liljeström
authors.affiliation: Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, 00076 Aalto (Finland) http://chemtech.aalto.fi/bihy.
authors.forename: Eve
authors.initials: E
authors.lastname: Saarikoski
authors.affiliation: VTT Technical Research Centre of Finland, 02044 VTT (Finland).
authors.forename: Jarmo
authors.initials: J
authors.lastname: Ropponen
authors.affiliation: Department of Applied Physics, Aalto University School of Science, 00076 Aalto (Finland).
authors.forename: Antti
authors.initials: A
authors.lastname: Nykänen
authors.affiliation: Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, 00076 Aalto (Finland) http://chemtech.aalto.fi/bihy.
authors.forename: Veikko
authors.initials: V
authors.lastname: Linko
authors.affiliation: Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, 00076 Aalto (Finland) http://chemtech.aalto.fi/bihy.
authors.forename: Jukka
authors.initials: J
authors.lastname: Seppälä
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, University of Helsinki, 00014 Helsinki (Finland).
authors.forename: Jouni
authors.initials: J
authors.lastname: Hirvonen
authors.affiliation: Department of Applied Physics, Aalto University School of Science, 00076 Aalto (Finland).
authors.forename: Olli
authors.initials: O
authors.lastname: Ikkala
authors.affiliation: Division of Pharmaceutical Chemistry and Technology, University of Helsinki, 00014 Helsinki (Finland). luis.bimbo@helsinki.fi.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Bimbo
authors.affiliation: Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Technology, 00076 Aalto (Finland) http://chemtech.aalto.fi/bihy. mauri.kostiainen@aalto.fi.
authors.forename: Mauri A
authors.initials: MA
authors.lastname: Kostiainen
mesh_terms: D050091:Dendrimers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D000431:Ethanol / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D010455:Peptides / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature
chemical_list: D050091:Dendrimers; D020100:Hydrogels; D010455:Peptides; D013501:Surface-Active Agents; D000431:Ethanol
keywords: amphiphiles; dendrimers; drug delivery; rheology; supramolecular gels