title: Serum Level of Heart-Type Fatty Acid Binding Protein (H-FABP) Before and After Treatment of Congestive Heart Failure in Children.
abstract: Remodeling of the heart following injury affects the morbidity and mortality in children presented with heart failure (HF). Heart-type fatty acid binding protein (H-FABP) is a novel biomarker that could be of help to predict the prognosis and risk stratification in those children. We aimed to evaluate the diagnostic and prognostic value of H-FABP in children with heart failure before and after treatment. The study was conducted as a prospective cohort study. It included 30 children with HF as a patient group and 20 healthy children matched for age and sex as a control group. Echocardiographic assessment of the heart was done using conventional Doppler echocardiography. Serum levels of (H-FABP) were measured using enzyme-linked immunosorbent assay before and after treatment of HF. All patients were observed during follow-up period of 3 months. There was a significant difference in the serum level of H-FABP in our patients before treatment (5.278 ± 3.253 ng/ml) compared with after treatment (2.089 ± 0.160 ng/ml) with significant difference compared with the control group. There was a significant increase in the serum level of H-FABP with increase in the severity of heart failure according to Ross classification. Significant increase in the H-FABP was associated with adverse outcome. Serum levels of H-FABP strongly correlated with clinical and echocardiographic assessment of LV performance of children with HF, and its levels significantly increased in children with adverse outcome suggesting its value as a useful diagnostic and prognostic predictor (with high sensitivity and specificity).
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Tanta University Hospital, Tanta University, Tanta, Egypt. azoair@hotmail.com.
authors.forename: Amr
authors.initials: A
authors.lastname: Zoair
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Tanta University Hospital, Tanta University, Tanta, Egypt. wegdanmawlana@hotmail.com.
authors.forename: Wegdan
authors.initials: W
authors.lastname: Mawlana
authors.affiliation: Department of Clinical Pathology, Tanta University Hospital, Tanta University, Tanta, Egypt.
authors.forename: Amany
authors.initials: A
authors.lastname: Abo-Elenin
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Tanta University Hospital, Tanta University, Tanta, Egypt.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Korrat
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002675:Child, Preschool; D015150:Echocardiography, Doppler; D004797:Enzyme-Linked Immunosorbent Assay; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins
keywords: Children; Heart failure; Heart-type fatty acid binding protein