title: PP026. Hyperuricemia in the prognosis of adverse perinatal outcomes.
abstract: BACKGROUND
  Elevated uric acid levels during the first or third trimester of gestation have been associated with poor perinatal outcomes in women with hypertensive pregnancies.
  
  
  OBJECTIVE
  Investigate whether uric acid levels are related to adverse perinatal outcomes in Chilean hypertensive women.
  
  
  METHODS
  It is a post-hoc analysis from a retrospective study including clinical records (n=416) of women with diagnosis of hypertension in pregnancy treated in the Hospital Clínico Herminda Martin, Chillán, Chile. From these records, 86 showed quantification of uric acid plasma levels at the moment of hypertension diagnosis ((3) 140/90mmHg; at 34±5weeks). Women were divided into three groups, considering uric acid levels below 25th percentile (Low group, n=27, <3.7mg/dl), from 25th to 75th percentile (Middle group, n=38, 3.8 to 5.7mg/dl) and above 75th percentile (High group, n=21, >5.8mg/dl) for the studied population.
  
  
  RESULTS
  In the entire group of hypertensive women, the uric acid/creatinine ratio was positively related to hospitalization days (p=0.04), and negatively associated with newborn weight (p=0.02) and size (p=0.01). ANOVA analysis did not show statistical differences in age, parity, systolic, diastolic or media blood pressure, body mass index, proteinuria, hepatic enzymes or hypoxia perinatal in women with low, middle or high uric acid levels. However, women with high uric acid levels showed a longer-hospitalization period (∼1.2days more), less platelet count (∼40×10(3)/ml) and high creatinine plasma levels (∼0.2mg/dl) and their babies showed less birth weight (∼800g) and were smaller (∼3cm) compared with women with low uric acid levels. Relative risk of intrauterine growth restriction in women with high levels of uric acid was 1.3 (CI, 0.96 to 1.73) compared with women with low levels.
  
  
  CONCLUSIONS
  These data reinforce the general agreement about the utility of hyperuricemia in the prognosis of adverse perinatal outcomes in hypertensive pregnancies.
authors.affiliation: Basic Science Department, Universidad del Bio Bio, Chillan, Chile.
authors.forename: C
authors.initials: C
authors.lastname: Escudero
authors.affiliation: Obstetric and Gynecology, Hospital Clinico Herminda Martin, Chillan, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Bertoglia
authors.affiliation: Basic Science Department, Universidad del Bio Bio, Chillan, Chile.
authors.forename: J
authors.initials: J
authors.lastname: Acurio
authors.affiliation: Basic Science Department, Universidad del Bio Bio, Chillan, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Escudero