title: Experimental cerebral and non-cerebral coenurosis in goats: A comparative study on the morphological and molecular characteristics of the parasite.
abstract: This experimental study was conducted to test whether cerebral and non-cerebral forms of Coenurus cerebralis belong to one origin or they are originated from two different tape worms. In the first step of the study, two groups of dogs were orally infected with the protoscoleces of cerebral and non-cerebral cysts and four months after infection, the adult worms were collected and morphologically characterized. Then the obtained eggs from two groups of adult worms were orally inoculated to two groups of goats to trace the predilection sites and also to compare the morphological and molecular characteristics of the larval stage of the parasites. The results showed that, both cerebral and non-cerebral coenuri, produced morphologically similar worms in the experimentally infected dogs. We observed only non-cerebral coenurus cysts in two groups of experimentally infected goats and the morphological characteristics of the cysts of two different groups were also similar. The molecular findings also showed that the cysts of two groups were 100% identical to each other based on the CO1 and nad1 sequences. In conclusion, our morphological and molecular findings reinforce the evidence that Taenia multiceps is the single origin of both cerebral and non-cerebral form of C. cerebralis but in goats, the cysts show more tendency to non-cerebral organs.
authors.affiliation: Department of Parasitology, School of Veterinary Medicine, Shiraz University, Shiraz 71345-17131, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Akbari
authors.affiliation: Department of Parasitology, School of Veterinary Medicine, Shiraz University, Shiraz 71345-17131, Iran. Electronic address: moazeni@shirazu.ac.ir.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Moazeni
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Oryan
authors.affiliation: Department of Clinical Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Sharifiyazdi
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Omidreza
authors.initials: O
authors.lastname: Amrabadi
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D002589:Cestoda / Q000502:physiology*; D002590:Cestode Infections / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000469:parasitology; D004285:Dogs; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D014644:Genetic Variation; D015511:Goat Diseases / Q000469:parasitology* / Q000473:pathology; D006041:Goats; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D015801:Helminth Proteins; D003576:Electron Transport Complex IV
keywords: CO1; Coenurus cerebralis; Experimental infection; Goats; Non-cerebral coenurosis; Taenia multiceps; nad1