title: Super-resolution links vinculin localization to function in focal adhesions.
abstract: Integrin-based focal adhesions integrate biochemical and biomechanical signals from the extracellular matrix and the actin cytoskeleton. The combination of three-dimensional super-resolution imaging and loss- or gain-of-function protein mutants now links the nanoscale dynamic localization of proteins to their activation and function within focal adhesions.
authors.affiliation: Univ. Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France and CNRS, Interdisciplinary Institute for Neuroscience, UMR 5297, F-33000 Bordeaux, France.
authors.forename: Grégory
authors.initials: G
authors.lastname: Giannone
mesh_terms: D022001:Focal Adhesions / Q000378:metabolism*; D006801:Humans; D049329:Nanostructures; D036103:Nanotechnology / Q000379:methods*; D016596:Vinculin / Q000378:metabolism*
chemical_list: D016596:Vinculin