title: Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression.
abstract: This study aims to address the role of focal adhesion proteins α- and β-parvin in human colorectal carcinoma (CRC). Expression of α- and β-parvin was examined by immunohistochemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated significantly with tumor invasion, lymph node metastasis, and disease stage. A significant positive correlation of parvins protein expression with overexpression of integrin-linked kinase, p-AKT, and nuclear β-catenin, as well as with downregulation of E-cadherin was also observed. In conclusion, overexpression of α- and β-parvin seems to be implicated in human colorectal cancer progression.
authors.affiliation: a Department of Anatomy-Histology-Embryology, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Bravou
authors.affiliation: b Molecular Oncology Laboratory, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Antonacopoulou
authors.affiliation: a Department of Anatomy-Histology-Embryology, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Papanikolaou
authors.affiliation: a Department of Anatomy-Histology-Embryology, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Nikou
authors.affiliation: a Department of Anatomy-Histology-Embryology, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Lilis
authors.affiliation: c Clinical Oncology Laboratory, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Efstathia
authors.initials: E
authors.lastname: Giannopoulou
authors.affiliation: b Molecular Oncology Laboratory, School of Medicine , University of Patras , Rio , Patras , Greece.|c Clinical Oncology Laboratory, School of Medicine , University of Patras , Rio , Patras , Greece.
authors.forename: Haralabos P
authors.initials: HP
authors.lastname: Kalofonos
mesh_terms: D000185:Actinin / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012016:Reference Values; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism; D000099200:Scaffold Protein ILK; D000096985:Calponins
chemical_list: D000185:Actinin; D015820:Cadherins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D051176:beta Catenin; D000099200:Scaffold Protein ILK; C495270:CTNNB1 protein, human; C486590:PARVA protein, human; D000096985:Calponins; C486591:PARVB protein, human
keywords: Alpha-parvin; Beta-parvin; Colorectal cancer; EMT; Focal adhesions; Integrin-linked kinase; Tumor progression