title: A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells.
abstract: A new natural halogen-containing stilbene derivative was isolated from the leaves of Cajanus cajan (L.) Millsp. and identified as 3-O-(3-chloro-2-hydroxyl-propanyl)-longistylin A by comprehensive spectroscopic and chemical analysis, and named cajanstilbene H (1). It is the first halogen-containing stilbene derivative found from plants. In human mesenchymal stem cells (hMSC) from bone marrow, 1 did not promote cell proliferation, but distinctly enhanced osteogenic differentiation of hMSC in time- and dose-dependent manners. In six human cancer cell lines, 1 showed a moderate inhibitory effect on cell proliferation, with IC50 values of 21.42-25.85 μmol·L(-1).
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. jiazhongcai@gzucm.edu.cn.|Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. jiazhongcai@gzucm.edu.cn.
authors.forename: Jia-Zhong
authors.initials: JZ
authors.lastname: Cai
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. tangrong0319@163.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. yeguifu0120@163.com.
authors.forename: Gui-Fu
authors.initials: GF
authors.lastname: Ye
authors.affiliation: Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. sxqiu@scbg.ac.cn.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Qiu
authors.affiliation: Program for Natural Product Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. zhangnenling@scbg.ac.cn.
authors.forename: Nen-Ling
authors.initials: NL
authors.lastname: Zhang
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Hu
authors.affiliation: Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. xshen2@gzucm.edu.cn.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Shen
mesh_terms: D036561:Cajanus / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects*; D006219:Halogens / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D006219:Halogens; D010936:Plant Extracts; D013267:Stilbenes
keywords: Cajanus cajan (L.) Millsp.; cajanstilbene H; halogen; human mesenchymal stem cells; osteogenic diffrentiation; stilbene