title: Anorexia in human and experimental animal models: physiological aspects related to neuropeptides.
abstract: Anorexia, a loss of appetite for food, can be caused by various physiological and pathophysiological conditions. In this review, firstly, clinical aspects of anorexia nervosa are summarized in brief. Secondly, hypothalamic neuropeptides responsible for feeding regulation in each hypothalamic nucleus are discussed. Finally, three different types of anorexigenic animal models; dehydration-induced anorexia, cisplatin-induced anorexia and cancer anorexia-cachexia, are introduced. In conclusion, hypothalamic neuropeptides may give us novel insight to understand and find effective therapeutics strategy essential for various kinds of anorexia.
authors.affiliation: Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Uezono
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ueta
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D001522:Behavior, Animal; D002100:Cachexia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D002945:Cisplatin; D003681:Dehydration / Q000150:complications; D004195:Disease Models, Animal; D005247:Feeding Behavior; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism* / Q000503:physiopathology; D009369:Neoplasms / Q000150:complications; D009479:Neuropeptides / Q000378:metabolism*; D012307:Risk Factors; D015398:Signal Transduction; D013045:Species Specificity
chemical_list: D009479:Neuropeptides; D002945:Cisplatin