title: Effects of gas produced by degradation of Mg-Zn-Zr Alloy on cancellous bone tissue.
abstract: Mg-Zn-Zr alloy cylinders were implanted into the femoral condyles of Japanese big-ear white rabbits. X-ray showed that by 12 weeks following implantation the implant became obscure, around which the low-density area appeared and enlarged. By 24 weeks, the implant was more obscure and the density of the surrounding cancellous bone increased. Scanning electron microscopy examination showed bone tissue on the surface of the alloy attached by living fibers at 12 weeks. Micro-CT confirmed that new bone tissue on the surface of the residual alloy implant increased from 12 weeks to 24 weeks. By 12 weeks, many cavities in the cancellous bone tissue around the implant were noted with a CT value, similar to gas value, and increasing by 24 weeks (P<0.01). Histological examination of hard tissue slices showed that bone tissue was visibly attached to the alloy in the femoral condyle at 12 weeks. The trabecular bone tissues became more intact and dense, and the cavities were filled with soft tissue at 24 weeks. In general, gas produced by the degradation of the Mg-Zn-Zr alloy can cause cavitation within cancellous bone, which does not affect osteogenesis of Mg alloy.
authors.affiliation: Tianjin Hospital, 300211 Tianjin, China.
authors.forename: Jingbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Hospital, 300211 Tianjin, China.
authors.forename: Hongfeng
authors.initials: H
authors.lastname: Jiang
authors.affiliation: School of Materials Science and Engineering, Tianjin University of Technology, 300384 Tianjin, China.
authors.forename: Yanze
authors.initials: Y
authors.lastname: Bi
authors.affiliation: School of Materials Science and Engineering, Tianjin University of Technology, 300384 Tianjin, China.
authors.forename: Jin e
authors.initials: Je
authors.lastname: Sun
authors.affiliation: School of Materials Science and Engineering, Tianjin University of Technology, 300384 Tianjin, China.
authors.forename: Minfang
authors.initials: M
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, Tianjin University of Technology, 300384 Tianjin, China.
authors.forename: Debao
authors.initials: D
authors.lastname: Liu
mesh_terms: D000497:Alloys; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D005740:Gases; D008274:Magnesium / Q000737:chemistry; D011817:Rabbits; D055114:X-Ray Microtomography; D015032:Zinc / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry
chemical_list: D000497:Alloys; D005740:Gases; D015040:Zirconium; D008274:Magnesium; D015032:Zinc
keywords: Animal model; Bone; Cavitation; Gas; Magnesium alloy implants