title: Cognitive Function and Control of Type 2 Diabetes Mellitus in Young Adults.
abstract: BACKGROUND
  Type 2 diabetes mellitus (T2DM) has been associated with impairment of cognitive function. Studies show a strong negative correlation between the levels of glycosylated hemoglobin and cognitive function in adult patients above the mean age of 60 years. In healthy adults, age-related cognitive impairment is mostly reported after the age of 60 years, hence the decline in cognitive function can be a part of normal aging without diabetes. Since the majority of patients with diabetes are between the ages of 40 and 59 years, it is crucial to ascertain whether the levels of glycosylated hemoglobin negatively correlate with the levels of cognitive function scores in adult patients of age 60 years or younger, similar to the way it correlates in patients older than 60 years of age, or not.
  
  
  OBJECTIVE
  We observed the relationship between the levels of glycosylated hemoglobin and the levels of cognitive function in patients of age 60 years or younger with T2DM.
  
  
  METHODS
  Eighty-two patients with T2DM underwent cognitive assessment testing by using a Modified Mini-Mental State Examination (3MS), and their cognitive function scores were correlated with their glycosylated hemoglobin levels, durations of diabetes, and levels of education.
  
  
  RESULTS
  Cognitive impairment was observed in 19.5% of the studied patients. We found a weakly negative relationship between the glycosylated hemoglobin level and cognitive function score (r = -0.292), a moderately negative relationship between the duration of diabetes and cognitive function score (r = -0.303), and a weakly positive relationship between the level of education and cognitive function score (r = 0.277).
  
  
  CONCLUSIONS
  Cognitive impairment affects one-fifth of the patients of age 60 years or younger with T2DM. It is weakly negatively related to the glycosylated hemoglobin level, moderately negatively related to the duration of diabetes, and weakly positively related to the level of education.
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Satyajeet
authors.initials: S
authors.lastname: Roy
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Nami
authors.initials: N
authors.lastname: Kim
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Anjali
authors.initials: A
authors.lastname: Desai
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Mahathi
authors.initials: M
authors.lastname: Komaragiri
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Namrata
authors.initials: N
authors.lastname: Baxi
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Navinder
authors.initials: N
authors.lastname: Jassil
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Blessinger
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Maliha
authors.initials: M
authors.lastname: Khan
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Cole
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Nayan
authors.initials: N
authors.lastname: Desai
authors.affiliation: Department of Medicine, Cooper University Hospital, Camden, New Jersey, USA.
authors.forename: Rocco
authors.initials: R
authors.lastname: Terrigno
authors.affiliation: Cooper Research Institute, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
authors.forename: Krystal
authors.initials: K
authors.lastname: Hunter
keywords: Cognitive function; cognitive impairment; diabetes; duration of diabetes; glycosylated hemoglobin; level of education; type 2 diabetes mellitus (T2DM)