title: The prevalence of HSV-2 infection in HIV-1 discordant couples.
abstract: We aimed to investigate the prevalence and associated factors of HSV-2 discordance and concordance in HIV-1-discordant couples. This study used the baseline data from a cohort study of HIV-1-discordant couples in Dehong prefecture of Yunnan province, China. Of 954 participating couples, 42·4% were affected by HSV-2, of which 20·4% were HSV-2-concordant positive, 7·6% were HSV-2-discordant where the male was HSV-2 positive, and 14·4% were HSV-2 discordant where the female was HSV-2 positive. Compared to HSV-2-negative concordance, HSV-2 discordance with an HSV-2-positive male spouse was significantly associated with characteristics of the male spouse, including Han ethnicity and being in a second marriage. HSV-2 discordance with an HSV-2-positive female spouse was significantly associated with characteristics of the female spouse, including Han ethnicity, having engaged in commercial sex, having a sexual relationship of <3 years and being HIV-1 infected. Compared to HSV-2 discordance, HSV-2-positive concordance was significantly associated with an education level of middle school or higher for both spouses, a sexual relationship of ⩾3 years, more frequent sex and having an HIV-1-infected male spouse. The findings highlight the need for HSV-2 prevention and treatment efforts to reduce HSV-2 transmission in this population, and emphasize the importance of implementing prevention interventions early in couples' relationships.
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention,Mangshi,Yunnan Province,China.
authors.forename: S
authors.initials: S
authors.lastname: Duan
authors.affiliation: Department of Epidemiology,School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education,Fudan University,Shanghai,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.affiliation: National Centre for AIDS/STD Control and Prevention (NCAIDS),Chinese Centre for Disease Control and Prevention (China CDC),Beijing,China.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.affiliation: National Centre for AIDS/STD Control and Prevention (NCAIDS),Chinese Centre for Disease Control and Prevention (China CDC),Beijing,China.
authors.forename: K
authors.initials: K
authors.lastname: Rou
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention,Mangshi,Yunnan Province,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention,Mangshi,Yunnan Province,China.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Epidemiology,School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education,Fudan University,Shanghai,China.
authors.forename: M
authors.initials: M
authors.lastname: Gao
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention,Mangshi,Yunnan Province,China.
authors.forename: R
authors.initials: R
authors.lastname: Ye
authors.affiliation: Dehong Prefecture Centre for Disease Control and Prevention,Mangshi,Yunnan Province,China.
authors.forename: L
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Department of Epidemiology,School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education,Fudan University,Shanghai,China.
authors.forename: N
authors.initials: N
authors.lastname: He
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005191:Family Characteristics; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006558:Herpes Genitalis / Q000453:epidemiology* / Q000821:virology; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012725:Sexual Behavior; D012747:Sexual Partners; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral
keywords: China; HIV-1; HSV-2; couples; discordant; prevalence