title: Comparison of Long-Term Clinical Outcomes after Drug-Eluting Stent Implantation in Patients with Coronary Artery Disease with and without Prior Cerebral Infarction.
abstract: OBJECTIVE
  To compare the clinical and angiographic outcomes after implantation of drug-eluting stents (DESs) in patients with coronary artery disease (CAD) with or without prior cerebral infarction.
  
  
  METHODS
  Ninety-eight consecutive patients (130 lesions) who underwent successful coronary DES implantation were prospectively classified into two groups: those with a clinical history of symptomatic cerebral infarction (cerebral infarction group, 49 patients, 69 lesions) and those without a clinical history of symptomatic cerebral infarction (noncerebral infarction group, 49 patients, 61 lesions). The primary endpoint was defined as death, nonfatal myocardial infarction, and cerebrovascular events.
  
  
  RESULTS
  The Kaplan-Meier method was used to create a primary endpoint curves to determine the time-dependent cumulative primary endpoint-free rate, which were compared using the log-rank test. The incidence of primary endpoints was higher in the cerebral infarction group than in the noncerebral infarction group (p = 0.0075). The Cox proportional hazards regression model for primary endpoint identified prior cerebral infarction (p = 0.0331, hazard ratio = 2.827) and patients with peripheral artery disease (p = 0.0271, hazard ratio = 2.757) as explanatory factors.
  
  
  CONCLUSIONS
  The results showed that clinical outcomes were poorer in patients with CAD who had prior cerebral infarctions than in those who did not have infarction.
authors.affiliation: Departments of Cardiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Hisataka
authors.initials: H
authors.lastname: Sasao
authors.affiliation: Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Fujiwara
authors.affiliation: Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Naruyoshi
authors.initials: N
authors.lastname: Horiuchi
authors.affiliation: Departments of Anesthesiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Shirasaki
authors.affiliation: Departments of Anesthesiology, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sakai
authors.affiliation: Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tsuchida
authors.affiliation: Departments of Neurosurgery, Sapporo Shuyukai Hospital, Sapporo, Hokkaido, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Murai
keywords: cerebral infarction; clinical outcome; coronary artery disease; drug-eluting stents