title: Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.
abstract: Hepatocellular carcinoma (HCC) is one of the most life-threatening malignancies worldwide. Defects in DNA repair genes may increase the risk of HCC. X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision re-pair. Recently, several studies have indicated that an association exists between XRCC1 polymorphism and HCC, particularly the Arg280His polymorphism. However, the data is inconsistent and incomplete. In this study, we conducted a meta-analysis to investigate the association between the XRCC1 Arg280His polymorphism and HCC risk. A total of 10 case-control studies included 1848 HCC cases and 1969 controls were examined in this analysis. Our results suggest that variant geno-types of the XRCC1 Arg280His gene are associated with a significantly increased risk of HCC in homozygote comparison (HisHis vs ArgArg, odds ratio, 1.55, 95% confidence interval, 1.10-2.18, P = 0.013); no het-erogeneity was observed (I2 = 0%). Our analysis suggests that the XRCC1 Arg280His polymorphism is associated with a higher risk of HCC.
authors.affiliation: Department of Bone Tumor, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: W
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Hematology, Guangdong No. 2 People's Provincial Hospital No. 1, Guangzhou, China.
authors.forename: S A
authors.initials: SA
authors.lastname: Liu
authors.affiliation: Department of Bone Tumor, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Shen
authors.affiliation: Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, wyl9900@163.com.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wu
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human