title: Dipeptidyl peptidase 4 concentration influenced by serum insulin levels rather than arterial stiffness index in type 2 diabetics.
abstract: OBJECTIVE
  To investigate whether inhibitors of dipeptidyl peptidase-4 (DPP-4) can suppress the atherosclerotic development in diabetic patients.
  
  
  METHODS
  The prospective study was carried out in the Out-patient Department of XuHui Central Hospital, Shanghai, China, between March and August 2013. The correlation of major index of glucose and lipid metabolism profiles, and the arterial stiffness index (AI) between diabetic patients and healthy subjects were analyzed.
  
  
  METHODS
  39 patients with type 2 diabetes and 29 healthy subjects were enrolled for measurements of blood glucose, plasma insulin, HbA1c, TC, cholesterol, HDL, AI and body mass index (BMI).
  
  
  RESULTS
  Significant differences were found between DPP-4 and blood glucose (fasting and 2 h postprandial), HbA1c, cholesterol, high density lipoprotein and arterial stiffness in normal subjects and diabetic patients. Only the fasting insulin concentration and high density lipoprotein had a significant impact on DPP-4 levels.
  
  
  CONCLUSIONS
  It was clear that insulin (fasting) and HDL levels had an impact on DPP-4 activity but only in patients with Type 2 diabetes. The arterial stiffness index was not correlated with DPP-4 levels in Type 2 diabetic patients.
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Geriatrics, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Risu
authors.initials: R
authors.lastname: Na
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Xulei
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Qiaorui
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Hongguang
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Department of Endocrinology, Xuhui District Central Hospital No. 966, Huaihai Zhong Road, Shanghai 200031, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Liu
keywords: Arterial stiffness index; DPP-4; HDL; cholesterol; insulin