title: Novel insights into red blood cell physiology using parasites as tools.
abstract: The mammalian red blood cell is a terminally differentiated cell that lacks a genetic programme and that has only a very limited metabolic capacity. Nonetheless, it serves as habitat for two parasites belonging to the monophyletic group of Apicomplexa, namely Plasmodium and Babesia. Studies of the parasitized red blood cell have revealed several properties that are unknown in the non-infected cell and that are difficult to conceptualize based on our view of red blood cell function. Here we review the current knowledge on host cell invasion and nutrient acquisition by these parasites. We attempt to dissect the factors that are directly contributed by the parasites from those that exist but have remained undetected in the non-infected cell.
authors.affiliation: Department of Parasitology, Philipps University Marburg, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany. Electronic address: baumeist@staff.uni-marburg.de.
authors.forename: Stefan
authors.initials: S
authors.lastname: Baumeister
authors.affiliation: Department of Parasitology, Philipps University Marburg, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany. Electronic address: gangopad@staff.uni-marburg.de.
authors.forename: Preetish
authors.initials: P
authors.lastname: Gangopadhyay
authors.affiliation: Department of Biosciences, University of Oslo, Blindernveien 31, 0316 Oslo, Norway. Electronic address: urska.repnik@ibv.uio.no.
authors.forename: Urska
authors.initials: U
authors.lastname: Repnik
authors.affiliation: Department of Parasitology, Philipps University Marburg, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany. Electronic address: lingelba@staff.uni-marburg.de.
authors.forename: Klaus
authors.initials: K
authors.lastname: Lingelbach
mesh_terms: D000818:Animals; D001403:Babesia / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D002451:Cell Compartmentation / Q000502:physiology; D002468:Cell Physiological Phenomena / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology; D006801:Humans; D010961:Plasmodium / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity
keywords: Babesia; Erythrocyte; New permeability pathways; Parasitophorous vacuole; Plasmodium