title: Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia.
abstract: The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca(2+)-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n=72) and non-hypertensive control patients (n=66) (χ(2), p=0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy.
authors.affiliation: Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Dept. of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Dept. of Pathology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: p.b.b.schol@hotmail.com.
authors.forename: P B B
authors.initials: PB
authors.lastname: Schol
authors.affiliation: Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: c.guzel@erasmusmc.nl.
authors.forename: C
authors.initials: C
authors.lastname: Güzel
authors.affiliation: Dept. of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: e.a.p.steegers@erasmusmc.nl.
authors.forename: E A P
authors.initials: EA
authors.lastname: Steegers
authors.affiliation: Dept. of Pathology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: r.dekrijger@erasmusmc.nl.
authors.forename: R R
authors.initials: RR
authors.lastname: de Krijger
authors.affiliation: Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: t.luider@erasmusmc.nl.
authors.forename: T M
authors.initials: TM
authors.lastname: Luider
keywords: Calcyclin; Pre-eclampsia; S100A6; Trophoblast