title: Clinical Long-Term Outcome and Reinterventional Rate After Uterine Fibroid Embolization with Nonspherical Versus Spherical Polyvinyl Alcohol Particles.
abstract: OBJECTIVE
  This study was designed to evaluate the long-term clinical outcome and frequency of reinterventions in patients with uterine fibroids treated with embolization at a single center using polyvinyl alcohol microparticles.
  
  
  METHODS
  The study included all patients with symptomatic uterine fibroids treated with uterine fibroid embolization (UFE) with spherical (s-PVA) and nonspherical (ns-PVA) polyvinyl alcohol microparticles during the period January 2001 to January 2011. Clinical success and secondary interventions were examined. Hospital records were reviewed during follow-up, and symptom-specific questionnaires were sent to all patients.
  
  
  RESULTS
  In total, 515 patients were treated with UFE and 350 patients (67 %) were available for long-term clinical follow-up. Median time of follow-up was 93 (range 76-120.2) months. Eighty-five patients (72 %) had no reinterventions during follow-up in the group embolized with ns-PVA compared with 134 patients (58 %) treated with s-PVA. Thirty-three patients (28 %) underwent secondary interventions in the ns-PVA group compared with 98 patients (42 %) in s-PVA group (χ(2) test, p < 0.01).
  
  
  CONCLUSIONS
  Spherical PVA particles 500-700 µm showed high reintervention rate at long-term follow-up, and almost one quarter of the patients underwent secondary interventions, suggesting that this type of particle is inappropriate for UFE.
authors.affiliation: Department of Radiology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark. stevo.duvnjak@rsyd.dk.|Odense Patient Data Explorative Network, Odense University Hospital, J.B. Winslows Vej 9 a, 5000, Odense, Denmark. stevo.duvnjak@rsyd.dk.
authors.forename: Stevo
authors.initials: S
authors.lastname: Duvnjak
authors.affiliation: Department of Gynecology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.
authors.forename: Pernille
authors.initials: P
authors.lastname: Ravn
authors.affiliation: Odense Patient Data Explorative Network, Odense University Hospital, J.B. Winslows Vej 9 a, 5000, Odense, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Green
authors.affiliation: Department of Radiology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.
authors.forename: Poul Erik
authors.initials: PE
authors.lastname: Andersen
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007889:Leiomyoma / Q000628:therapy*; D008875:Middle Aged; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000627:therapeutic use*; D019233:Retreatment; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011142:Polyvinyl Alcohol
keywords: Arterial intervention; Embolization; Embolotherapy; Uterine fibroid embolization (UFE)