title: Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway.
abstract: OBJECTIVE
  To investigate if oxymatrine pretreatment could ameliorate renal I/R injury induced in rats and explore the possible role of oxymatrine in Nrf2/HO-1 pathway.
  
  
  METHODS
  Unilaterally nephrectomized rats were insulted by I/R in their left kidney. Twenty four rats were randomly divided into three groups: sham group, I/R + saline-treated group, I/R + OMT-treated group. Oxymatrine or vehicle solution was administered intraperitoneally injected 60 min before renal ischemia, respectively. Renal function, histology, makers of oxidative stress, cell apoptosis and Nrf2/HO-1 expressions were assessed.
  
  
  RESULTS
  Oxymatrine pretreatment exhibited an improved renal functional recovery, alleviated histological injury and oxidative stress, inhibiting tubular apoptosis, and accompanied by upregulated the expression of Nrf2/HO-1 proteins.
  
  
  CONCLUSIONS
  Oxymatrine may attenuate renal ischemia/reperfusion injury, and this renoprotective effect may be through activating the Nrf2/HO-1 pathway.
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Guanjun
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Xiuheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Urology, Renmin Hospital, Wuhan University, Wuhan, Hubei, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Qiu
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D004195:Disease Models, Animal; D051547:Heme Oxygenase-1 / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D007668:Kidney / Q000098:blood supply* / Q000473:pathology; D008297:Male; D051267:NF-E2-Related Factor 2 / Q000032:analysis / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D011807:Quinolizines / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D051547:Heme Oxygenase-1; D051267:NF-E2-Related Factor 2; D011807:Quinolizines; C037573:oxymatrine; D000093842:Matrines