title: The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population.
abstract: Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we also investigated the heritability of the RETN susceptible allele from 140 trio families with acne affected offspring. The genotyping was performed by polymerase chain reaction and direct DNA sequencing. The RETN-420C/G polymorphism was significantly associated with acne in patients compared with healthy controls (P=0.014). The minor allele G at -420 was more prevalent in cases vs. controls (P=0.002). The RETN-420C/G polymorphism was significantly associated with severity of acne vulgaris in patients (P=0.0097). The results of a transmission disequilibrium test revealed a significant association between the RETN-420C/G polymorphism and acne vulgaris (P<0.001). For the first time in the literature, to our knowledge, we demonstrate a significant association of the RETN-420C/G functional polymorphism with familial acne vulgaris.
authors.affiliation: Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-46000, Pakistan.
authors.forename: Sabir
authors.initials: S
authors.lastname: Hussain
authors.affiliation: Department of surgery, Government Post Graduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Faraz
authors.affiliation: Department of Internal Medicine, Shifa College of Medicine, Shifa International Hospital, H-8/4, Islamabad, Pakistan.
authors.forename: Tahir
authors.initials: T
authors.lastname: Iqbal
keywords: Acne; Association; Gene; Polymorphism; Resistin