title: Phenomenon of individual difference in human monocyte activation.
abstract: Macrophages play an important role in the pathogenesis of atherosclerosis, including the early pre-clinical stages of the disease development. We have explored the possibility that the disease onset could be associated with altered monocyte/macrophage response to activating pro- and anti-inflammatory stimuli. We evaluated the susceptibility of circulating monocytes from healthy individuals and patients with asymptomatic carotid atherosclerosis to M1 and M2 activation. The obtained data indicated the existence of a remarkable individual difference in susceptibility to activation among monocytes isolated from the blood of different subjects, regardless of the presence or absence of atherosclerosis. The identified differences in susceptibility to activation between monocytes may explain the individual peculiarities of the immune response in different subjects.
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia; Department of Biophysics, Faculty of Biology, Moscow State University, Moscow 119991, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia.
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Orekhov
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia.
authors.forename: Nikita G
authors.initials: NG
authors.lastname: Nikiforov
authors.affiliation: Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia.
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Elizova
authors.affiliation: Katholieke Universiteit Leuven, Department of Growth and Regeneration, Campus Gasthuisberg O&N1 Herestraat 49-BUS 817, 3000 Leuven, Belgium. Electronic address: kate.ivanov@gmail.com.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Ivanova
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119991, Russia.
authors.forename: Vsevolod J
authors.initials: VJ
authors.lastname: Makeev
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002340:Carotid Artery Diseases / Q000276:immunology* / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D019742:Chemokines, CC / Q000235:genetics / Q000378:metabolism; D003430:Cross-Sectional Studies; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008264:Macrophages; D009000:Monocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism
chemical_list: C111792:CCL18 protein, human; D019742:Chemokines, CC; D014409:Tumor Necrosis Factor-alpha
keywords: Activation; Cholesterol; Cytokine; Individual profile; Monocyte