title: MDS-UPDRS to assess non-motor symptoms after STN DBS for Parkinson's disease.
abstract: OBJECTIVE
  To determine if the non-motor sections of the Movement Disorder Society's (MDS) version of the Unified Parkinson's Disease Rating Scale (UPDRS) could supplement the original UPDRS as a patient completed assessment of changes in non-motor symptoms in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS).
  
  
  METHODS
  Thirty PD patients who underwent bilateral STN DBS were assessed using the total UPDRS and the non-motor sections of the MDS-UPDRS prior to surgery and one year following surgery. This study focuses on non-motor symptoms as assessed by Part I of the UPDRS and Part 1A and 1B of the MDS-UPDRS.
  
  
  RESULTS
  One year following surgery, no individual non-motor symptoms or the total mentation score of the UPDRS were significantly changed. In comparison, the MDS-UPDRS showed significant improvements in sleep and urinary problems and a trend towards improvement in anxiety, constipation, daytime sleepiness, fatigue and pain.
  
  
  CONCLUSIONS
  This study provides evidence that the MDS-UPDRS non-motor sections, when completed by the patients, can supplement the original version of the UPDRS as an effective method of measuring changes in non-motor symptoms after DBS. It also reinforces the benefits of bilateral STN DBS on non-motor symptoms of PD.
authors.affiliation: a 1 University of Kansas School of Medicine , USA.
authors.forename: Nickey
authors.initials: N
authors.lastname: Jafari
authors.affiliation: b 2 Department of Neurology.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Pahwa
authors.affiliation: c 3 Department of Neurosurgery , University of Kansas Medical Center , Kansas City , KS , USA.
authors.forename: Jules M
authors.initials: JM
authors.lastname: Nazzaro
authors.affiliation: c 3 Department of Neurosurgery , University of Kansas Medical Center , Kansas City , KS , USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Arnold
authors.affiliation: b 2 Department of Neurology.
authors.forename: Kelly E
authors.initials: KE
authors.lastname: Lyons
mesh_terms: D000368:Aged; D001007:Anxiety / Q000209:etiology / Q000628:therapy; D003072:Cognition Disorders / Q000209:etiology / Q000628:therapy; D003248:Constipation / Q000209:etiology / Q000628:therapy; D046690:Deep Brain Stimulation; D005221:Fatigue / Q000209:etiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D020919:Sleep Disorders, Intrinsic / Q000209:etiology / Q000628:therapy; D020531:Subthalamic Nucleus / Q000503:physiopathology; D063189:Symptom Assessment / Q000379:methods*; D016896:Treatment Outcome
keywords: MDS-UPDRS; Parkinson's disease; deep brain stimulation; non-motor symptoms; subthalamic nucleus