title: Effect of Cadmium on Cellular Ultrastructure in Mouse Ovary.
abstract: This study aimed at analyzing the cytotoxicity and pathological effects of cadmium on the ovary. Our studies revealed that cadmium was deposited in the mouse ovary after 8 d cadmium injection in vivo. Also, the increase in the rate of body weight was slowed, while the gonadosomatic index was reduced in the CdCl2 group, compared with the control group. Meanwhile, cadmium affected the maturation of follicles, the degradation of corpus luteum, the arrangement of follicles and corpus luteum, and increased the number of atresia follicles. Besides, under the electron microscope, chromatin margination, karopyknosis, swelling of mature cisternae of Golgi apparatus, mitochondrial cristae disappearance, and swelling of the rough endoplasmic reticulum can be observed in the CdCl2 group mice. Collectively, our findings elucidated the morphological mechanism that the exposure of cadmium changed the ultrastructure of cells in ovary tissues.
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.
authors.forename: Chao
authors.initials: C
authors.lastname: Qiu
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.|b Hubei Provincial Key Laboratory of Developmentally Originated Disease , School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhong
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.|b Hubei Provincial Key Laboratory of Developmentally Originated Disease , School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wei
authors.affiliation: a School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China and.|b Hubei Provincial Key Laboratory of Developmentally Originated Disease , School of Basic Medical Sciences, Wuhan University , Wuhan , Hubei , P.R. China.
authors.forename: Daji
authors.initials: D
authors.lastname: Luo
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010053:Ovary / Q000187:drug effects* / Q000473:pathology*; D013054:Spectrophotometry, Atomic
chemical_list: D002104:Cadmium
keywords: Cadmium; mouse ovary; ultrastructure changes