title: Cinnamic Acid and Cinnamaldehyde Ameliorate Cisplatin-Induced Splenotoxicity in Rats.
abstract: Cinnamic acid (CA) and cinnamaldehyde (CD) are major constituents of cinnamon species. They possess various pharmacological properties of which their antioxidant activity is a prime one. This study aims to investigate potential protective effects against cisplatin (CP)-induced splenotoxicity in rats. A single dose of CP (5 mg/kg) injected i.p. caused a significant decrease in hemoglobin content (18%), total leucocytic count (46%), neutrophils (78%), and catalase (CAT) splenic activity (64%) with a marked increase in lymphocytes (26%) and splenic content of malondialdehyde (68%) and TNF-α (69%) as compared with the control group. Contrarily, CA (50 mg/kg, p.o.) or CD (40 mg/kg, p.o.) administration for 7 days before CP ameliorated CP-induced splenotoxicity as indicated by mitigation of the biochemical parameters and histopathological changes. These results revealed the promising protective effects of CA and CD on CP-induced splenotoxicity in rats; an effect that might be attributed to antioxidant and anti-inflammatory activities.
authors.affiliation: Pharmacolgy Department, National Organization for Drug Control and Research, NODCAR, Cairo, Egypt.
authors.forename: Ola M
authors.initials: OM
authors.lastname: Abd El-Raouf
authors.affiliation: Pharmacolgy & Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.
authors.forename: El-Sayed M
authors.initials: EM
authors.lastname: El-Sayed
authors.affiliation: Pharmacolgy Department, National Organization for Drug Control and Research, NODCAR, Cairo, Egypt.
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Manie
keywords: Antioxidant; Cinnamaldehyde; Cinnamic acid; Cisplatin; Splenotoxicity