title: Clinical and pathological features and treatment of AIDS-related cutaneous Kaposi's sarcoma in Chinese Han patients.
abstract: This retrospective study aimed to observe the clinicopathological features and immunological phenotypes, and explore effective treatment and prognosis for 12 Chinese Han patients with acquired immunodeficiency syndrome-related cutaneous Kaposi's sarcoma. All 12 patients were human immunodeficiency virus-positive, and underwent the standard highly active antiretroviral therapy (HAART). Skin lesions mainly presented as purple, or rufous papules, or plaques; skin biopsy showed diffuse or flaky infiltration of spindle cells, active proliferation of slit-like vasculature, erythrocyte exudation, hemosiderin deposition, and inflammatory cell infiltration. Immunohistochemical analysis showed the expression of Ubiquitin C-terminal hydrolase L1 (+), and CD31 (+) in T-cells; factor VIII (+) and HHF-35 (+) in the proliferating vascular endothelial cells; vimentin (+) and S-100 protein (-) in the vessel wall; and CD34 (+++) in the spindle cells of 6 cases, with 1 case of negative CD34 expression. Four patients with confined lesions underwent surgery and microwave therapy, and received a favorable prognosis. Two patients with limited lesions underwent microwave therapy, and the lesions subsided. Of six patients with widely distributed sarcomas, five underwent microwave therapy and one received combined chemotherapy; five attained significant efficacy, and one died. There were no significant differences in the clinicopathological features and immunological phenotypes between the Chinese Han patients and those from other populations. Along with basal HAART, patients in early stages, with sarcomas <2 cm in diameter should undergo surgery and microwave therapy, while patients with sarcomas >2 cm in diameter should undergo chemotherapy and microwave therapy.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: X-K
authors.initials: XK
authors.lastname: Zheng
authors.affiliation: Department of Dermatology-Venereology & AIDS, Guangzhou Eighth People's Hospital, Guangzhou, China.
authors.forename: S-H
authors.initials: SH
authors.lastname: Lu
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
authors.forename: J-F
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China laiyingrong_lyr@163.com.
authors.forename: Y-R
authors.initials: YR
authors.lastname: Lai
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D000328:Adult; D018952:Antigens, CD34 / Q000235:genetics / Q000378:metabolism; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D062109:Dermatologic Surgical Procedures; D042783:Endothelial Cells / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D005169:Factor VIII / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006678:HIV / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D012189:Retrospective Studies; D009418:S100 Proteins / Q000235:genetics / Q000378:metabolism; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D012867:Skin / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D016896:Treatment Outcome; D043222:Ubiquitin Thiolesterase / Q000235:genetics / Q000378:metabolism; D014746:Vimentin / Q000235:genetics / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D009418:S100 Proteins; C482860:UCHL1 protein, human; D014746:Vimentin; D005169:Factor VIII; D043222:Ubiquitin Thiolesterase