title: A new isoflavanone from the trunk of Horsfieldia pandurifolia.
abstract: A new isoflavanone, 2,2'-epoxy-4'-methoxy-3,7-dihydroxyisoflavanone (1), and a new natural coumaranone, 2-hyroxy-2-(4'-methoxybenzyl)-6-methoxy-3-coumaranone (2), along with 26 known compounds, were first isolated from the trunk of Horsfieldia pandurifolia. Their structures were elucidated by the means of spectroscopic analysis. Compound 1 was assessed for its cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it has no activity.
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Chenggong New District, Kunming 650500 , P.R. China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Ma
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Chenggong New District, Kunming 650500 , P.R. China.
authors.forename: Yujiao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Chenggong New District, Kunming 650500 , P.R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhan
authors.affiliation: a School of Chemistry and Chemical Engineering , Yunnan Normal University , Chenggong New District, Kunming 650500 , P.R. China.
authors.forename: Yegao
authors.initials: Y
authors.lastname: Chen
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007529:Isoflavones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D026324:Myristicaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000609490:2,2'-epoxy-4'-methoxy-3,7-dihydroxyisoflavanone; C000609491:2-hyroxy-2-(4'-methoxybenzyl)-6-methoxy-3-coumaranone; D001593:Benzyl Compounds; D003374:Coumarins; D007529:Isoflavones; C065753:isoflavanone
keywords: Horsfieldia pandurifolia; Myristicaceae; isoflavanone