title: Internalization, Trafficking, Intracellular Processing and Actions of Antibody-Drug Conjugates.
abstract: OBJECTIVE
  This review discusses the molecular mechanism involved in the targeting and delivery of antibody-drug conjugates (ADCs), the new class of biopharmaceuticals mainly designed for targeted cancer therapy.
  
  
  METHODS
  this review goes over major progress in preclinical and clinical studies of ADCs, in the past 5 years.
  
  
  RESULTS
  The pharmacokinetics and pharmacodynamics of ADCs involve multiple mechanisms, including internalization of ADCs by target cells, intracellular trafficking, release of conjugated drugs, and payload.
  
  
  CONCLUSIONS
  These mechanisms actually jointly determine the efficacy of ADCs. Therefore, the optimization of ADCs should take them as necessary rationales.
authors.affiliation: Scientific Development Manager, Discovery Biology, GenScript USA Inc., 860 Centennial Ave., Piscataway, New Jersey, 08854, USA. ben.xu@genscript.com.
authors.forename: Shi
authors.initials: S
authors.lastname: Xu
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D024201:Bystander Effect; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000379:methods*; D065546:Drug Liberation; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D058990:Molecular Targeted Therapy; D010873:Pinocytosis; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D018796:Immunoconjugates; D011956:Receptors, Cell Surface
keywords: Antibody drug conjugate; Internalization; Linker; Recycling; Trafficking