title: Glycogenic hepatopathy is an under-recognised cause of hepatomegaly and elevated liver transaminases in type 1 diabetes mellitus.
abstract: Glycogenic hepatopathy (GH) is an under-recognised complication of type 1 diabetes mellitus (T1DM) not controlled to target resulting in hepatomegaly and elevated liver transaminases. We report the case of a 19-year-old man with T1DM not controlled to target who presented with abdominal pain, hepatomegaly and deranged liver transaminases. He was subsequently diagnosed with GH on liver biopsy, with the mainstay of treatment being reduction in caloric intake and insulin.
authors.affiliation: Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: N R
authors.initials: NR
authors.lastname: Irani
authors.affiliation: Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Venugopal
authors.affiliation: Department of Gastroenterology and Hepatology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Kontorinis
authors.affiliation: Department of General Medicine, Swan District Hospital, Perth, Western Australia, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Pathology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Sinniah
authors.affiliation: Department of General Medicine, Swan District Hospital, Perth, Western Australia, Australia.|School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: T R
authors.initials: TR
authors.lastname: Bates
mesh_terms: D001706:Biopsy; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006008:Glycogen Storage Disease / Q000097:blood / Q000209:etiology*; D006529:Hepatomegaly / Q000097:blood / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D000637:Transaminases / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008112:Liver Glycogen; D000637:Transaminases; C517652:hemoglobin A1c protein, human
keywords: diabetes; glycogen; hepatomegaly; liver; transaminitis