title: Successful treatment of lower urinary tract infections with oral fosfomycin: a report of three cases.
abstract: Infections due to multidrug-resistant organisms continue to increase, and therapeutic options remain scarce. Given this challenge, it has become necessary to use older antimicrobials for treatment of these pathogens. We report three patients with lower urinary tract infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae who were successfully treated with a seven-day course of oral fosfomycin monotherapy.
authors.affiliation: Setor de Doenças Infecciosas, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Juliana Oliveira
authors.initials: JO
authors.lastname: da Silva
authors.affiliation: Setor de Doenças Infecciosas, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Maria Cecilia Zorat
authors.initials: MC
authors.lastname: Yu
authors.affiliation: Setor de Doenças Infecciosas, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: André
authors.initials: A
authors.lastname: Doi
authors.affiliation: Hospital do Coração, São Paulo, São Paulo, Brazil.
authors.forename: Maria Rita Elmor
authors.initials: MR
authors.lastname: de Araujo
authors.affiliation: Hospital do Coração, São Paulo, São Paulo, Brazil.
authors.forename: Pedro Aurélio Mathiasi
authors.initials: PA
authors.lastname: Neto
authors.affiliation: Setor de Doenças Infecciosas, Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Guilherme Henrique Campos
authors.initials: GH
authors.lastname: Furtado
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D052978:Disk Diffusion Antimicrobial Tests; D005260:Female; D005578:Fosfomycin / Q000627:therapeutic use*; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D001618:beta-Lactamases