title: Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms.
abstract: The abdominal aortic aneurysm (AAA) is a disease process that carries significant morbidity and mortality in the absence of early identification and treatment. While current management includes surveillance and surgical treatment of low- and high-risk aneurysms, respectively, our narrow understanding of the pathophysiology of AAAs limits our ability to more effectively manage and perhaps even prevent the occurrence of this highly morbid disease. Over the past couple of decades, there has been considerable interest in exploring the role of autoimmunity as an etiological component of AAA. This review covers the current literature pertaining to this immunological process, focusing on research that highlights the local and systemic immune components found in both human patients and murine models. A better understanding of the autoimmune mechanisms in the pathogenesis of AAAs can pave the way to novel and improved treatment strategies in this patient population.
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana; and.
authors.forename: Tiffany W
authors.initials: TW
authors.lastname: Chang
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana; and.
authors.forename: Adam S A
authors.initials: AS
authors.lastname: Gracon
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana; and.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana dsw4n@virginia.edu.
authors.forename: David S
authors.initials: DS
authors.lastname: Wilkes
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology / Q000276:immunology*; D015551:Autoimmunity; D006801:Humans
keywords: abdominal aortic aneurysm; antigens; autoimmunity